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<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4R9</accession>
    <name>A0A9P4P4R9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ankyrin repeat protein nuc-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_373747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001517">
        <property type="protein sequence ID" value="KAF2437297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="34"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="523"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="737"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2437297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1607" mass="179882" checksum="FF38420A5181A011" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5Q7</accession>
    <name>A0A9P4P5Q7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_437546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5Q7"/>
    <dbReference type="OrthoDB" id="3933243at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="170" mass="19052" checksum="6C8FB789982CCE1D" modified="2023-09-13" version="1">METDVATAAKPINTPEALPAYPMSRRQGNAVQNGFGGQGFNFIDGFNRFNDQAQVVQVKQEVLQIQDNGFQQQVVQQVNEVLVVNQEQNGFNNDLNNLFRKANFRRERDQESTVMLVVQQIQVSVADDRGNAFEQEVFVQSAIVANRGARSTNTVMRMCLLTPCFPAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5Y3</accession>
    <name>A0A9P4P5Y3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate esterase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_373461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5Y3"/>
    <dbReference type="OrthoDB" id="426133at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01831">
        <property type="entry name" value="Endoglucanase_E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040794">
        <property type="entry name" value="CE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037461">
        <property type="entry name" value="CtCE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052762">
        <property type="entry name" value="PCW_deacetylase/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834:SF2">
        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17996">
        <property type="entry name" value="CE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040247118" evidence="1">
        <location>
            <begin position="20"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate esterase 2 N-terminal" evidence="3">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="130"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2437358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="344" mass="36216" checksum="36F1827EFD6340F4" modified="2023-09-13" version="1">MKHFSAVALSLAILDIAQAVRFLGRVNPATRELTWAGTGVAFSFTGSSATIGFESVTGANSVLLTVDGKSTVIPNVNSSSISTPAGLAKGKHTVELRKRSEAFFGSIFIGNVTTNGVLGPDPRRNRKIEFIGDSITVGYGMDGVLPCTNTAELEDNPNTYAVLAANSLKAEYDIVAWSGIGLVRNTAWGPAGDPTMTSRWTKYGAQDADNSYTFPSSEIPDAVVIALGTNDFSIANNNRDPLDVGNFSSATASFVRTIQKRYPKAQFFLVTSPMLGDSSAGEGEHTAQKKAFTDAAAQFKGKKAHVVDWPTQGSAVGCDYHPNVATNAAQAPVLASAIAKALGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6B5</accession>
    <name>A0A9P4P6B5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_449868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6B5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="473" mass="50554" checksum="E1B4D2B1EC11224B" modified="2023-09-13" version="1">MARLSNGPPRLSAKVRAKAKARVPVPPVLESEAEAEPEPEPEPEPEPEPEAEAVAVVVADADAEMAPSKEVARASSNARKRKATATEEAPPAAPSAKVRAKAKARVPVPPVSESEADAEMAPSSKEVARASSNARERKVTETEAPPAKSRGNFKAVGARAVKARDGKAKVAKWSDASDVPFTTTPSPRHALEIFLVPQKFKFGAEHQRDSVTWTRGKKTGKVKVGDIVQIEVARDHCLHRFRNYLLIMKTWTYTPEGFAEEEYVAAAWFYRRVEAEWVDVYIANHHWPEGKTHVLASHFAILHAGALRGPAPACELRKLEWKQFINFEKDKEHRGELQSIFDSQPSDLATTVREHLLLPGADDDEAVPDTGVLADADADADEDADVEVTAGPSTGLFPSSLPGPSTGPSSAGPYPGLWPGPSGPSPRPFPGLSTGPSSAGPSPGLWPGPSAAPASTKFPHANGDGGARSTVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P743</accession>
    <name>A0A9P4P743_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_477078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P743"/>
    <dbReference type="OrthoDB" id="3785721at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="408" mass="44445" checksum="B2D1950A61D2077F" modified="2023-09-13" version="1">MPPKHNGQHKPANIIVGRAGQSGQTFNDTSLLPFLRAYTRMNSRDAGGGDRQFNEEFNLARRIVEELNRYRDAPPDFIHDLVYSIANPNPDQQPMYPTLRSQGVSDQTAYQNRIIVSVLLMMHATNDGDGGVTRGGLWLPPRQQARDAQDAAAQRGQAVRYPTWSRDEAEASTPSRNANWTASGRPLMQQPQAGSLRSLRSQGFNSAVGNLPPFSSSFTPTPQSYGRSLAGAVLGPPSAGLGGYHWSSRGPQQYPSNSSLHSEYGVPPPPAVEPRRYVQDTLRSVLPQGNESAPYNTAATSARDLSDHPFWQPSHPPTTQRGQSSGFVPPPPGLEGMDHISAFGSETNSPIRPAQRPIGSDRPHHDSRRHGGSRSSHGDSARGTPSRPAPGSTSRSRDSRSRRDDQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P757</accession>
    <name>A0A9P4P757_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_339571</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P757"/>
    <dbReference type="OrthoDB" id="9975959at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="63"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2439645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="330" mass="37211" checksum="5EB98BC26D77022F" modified="2023-09-13" version="1" fragment="single">PKAILEAFQKALISGPAQKLGDAAYYKPRPQPFYYYNGSSWVSSSPKYPSKGAIFPTKNLRVISWNIDMLIGFAEERMSAALEHLSTLVEGTSKDVPVVIFLQEMSQSDMQQIRDAPFIQHRFHITDLDERNWLGPLYGTNTLIDLRLNINSIFRVPWISKFDRDGLFVDLAFSEQGKGKVLRLCNTHLESLVADPPIRPLQLQAAAPYLHDSSVAAALLAGDLNAIQPFDRTLHSENDLKDVYLELGGQEDSDDGYTWGYQVPQALRERFGCSRMDKILFSGALRPQKFERIGMGVKVAEGKRQEMKAAGEQEWVTDHYGVMADFHLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8I8</accession>
    <name>A0A9P4P8I8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_435205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8I8"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040143064" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2440395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="135" mass="14512" checksum="E0B51408EE8E59C7" modified="2023-09-13" version="1">MKVAVILALATAAVADIINNEHLKTEVVNKVECNRPTKAGDGIQVHYRGTLESDGSEFDASYNRGQPLGFTVGKGQVIKGWDQGLLDMCPGEKRKLTIQPDWAYGSRGAGPIPANSVLIFETELVSIDGVSKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8Q2</accession>
    <name>A0A9P4P8Q2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_490948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8Q2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="270" mass="30136" checksum="DF041084B71CB1DE" modified="2023-09-13" version="1">MTDRHTDGREEGMMGGKQKEKEKEKKSIRGRLGDALRQRLWQRLRLCVFKTRRNERQGSANGTTTITTTTTRSASTSTSTSTSAQDVYPHQEEDAVSNASSSTFTNDSATIAYTQSSTQSTTQFGSDSETATIEQDIAAPQPPPLPGRAFLPRGSGEGGRVRSGDIYRRGTRAWDVDWEGHQQDQGPRVPARYDHPQKRRLVAIVYKSPGSGDEGWTVPGRQQREEEDGEGEEEVLRSLAVRIRARERNWFVVERRRGGSEGVVHEEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P952</accession>
    <name>A0A9P4P952_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_476218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1888" mass="205640" checksum="6A9C755A49726A1A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P964</accession>
    <name>A0A9P4P964_9PLEO</name>
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        <submittedName>
            <fullName evidence="3">DUF1365-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">P171DRAFT_370110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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        <location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="669" mass="76564" checksum="1E1327F079A30A1E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="16755" checksum="68E98D415B80BA74" modified="2023-09-13" version="1">MAPPPEGSQFYQLQTKSATAAVSGQWVALKTGSTSYSLAAQQAAATKFFVNKYTPTGTFAVYNADDTRQLALQGPNGILLSLVDATNPSTDTIPKGTLMEWATFTLDNNVLFVKDGSTLVNRTFVAVKGSGSDYSVALYDGASTTTSNITPVTINIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB81</accession>
    <name>A0A9P4PB81_9PLEO</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">P171DRAFT_435700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5279806at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="412" mass="47342" checksum="0878B8D6196894BB" modified="2023-09-13" version="1">MGTEVKWHRLLDSIPGFKRQSGVTRGRQPLRLNDLPDDILILILSQCRVDEIFALRGTCSTFRNVFSTYSAHIIPWVARCTFPGGKLLLEPPTAPTGYTFAWLKERIPLQLAAILIDRYRFIFEEQPVRSQIGIPAEDALGSVFRNRVANGWRVLGRLSNISKEIYRLDAKKIFSMLNKKATWLLAHTSRYEAEIVRLREELVLQRRLQFIDTMSFHEAEDYVMMFTLLSGVWRVRKSDSLVSKDEPTWPFDFGRGIDAPRMIRKGESWVTWFILHQGPGLFWEQWWSLPSEAPETTNHVRDRAIEAFFSPLRREEDATHRRADFSDPQEELHDMQRLCAEKVQRAIVATCGASAPTLHFHYQIKYAQDRRLIDLDSDINPATSGVAETMNGVPAFINFSVYEPAKGAAESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCH5</accession>
    <name>A0A9P4PCH5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_343103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCH5"/>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial resolvase Ydc2 catalytic" evidence="1">
        <location>
            <begin position="53"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="366" mass="41675" checksum="8221FFF7529C637B" modified="2023-09-13" version="1" fragment="single">TVKAVQEVLRCIGEASAGTKDVVQNRLLTKAVCRKLPRTNWPRGDEEKKSSRILSIDMGIKNLAYCVADVEKPASTHDTTNMNFLSWRRLDLSEAFREYDVDLLGGAVETLEKKAVLEGREDEDLYTPENLSRMGYWFLRKILDDWNPDVILIERQRWRSAGSPSIQQWTVRVNTLEAVMWAVMTALKTERKKHFDRRMHAVDPKRVGHFWLDGVTPMPAPPRTGKKKVSKLLSKSEDEDIIGAVDDGDAGSTKKLTRGKAEKRAKISLLRTWLDSEHPSTTLSTSEKTAETGTLYPNISFTFSHQERSDSLNYGADGTRQALLYATDKPSERAKRTRYYKAYVRKVDDITDCFLQAAAWVAWDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD01</accession>
    <name>A0A9P4PD01_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD01"/>
    <dbReference type="OrthoDB" id="4124983at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="175" mass="19676" checksum="F8EEA84D9C1DD2A3" modified="2023-09-13" version="1">MDDEARQALAKMDMPRRPINFVPAKSGEILKLGHITCRVMEDGSRTDNRIGSAEFTVPAGTAGPPAHWHEMHDETFLVTQGTVRFHAPDNTIVDAKVGDYVTVPIRAPHTFSNPFEVEAKFFNTFTPAFYIDYFKILAEVSKSDEKMSKEKNLEVMARFATMPAKPLMDEVAKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD71</accession>
    <name>A0A9P4PD71_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_446543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD71"/>
    <dbReference type="OrthoDB" id="3789421at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29667" checksum="BBEFFF2F028AA785" modified="2023-09-13" version="1">MAPTADKPAMAGTKRKFNMFAMDQELVDFLVDGKQFSVHEGLLQHIIPSWGSAFGPSERFPRVGNAWAIPDTSPWAFCGFMHWLYNQELPNETMLKEKECPHGFDIGTESEPLACSMAVDLYDIGQMLGVTSLRDAALAHVFREYQSANIVPDMDRTWQVFGFDGQKERTGNICELLVDVCLKRKELCRPLIQEAADIGADLLPRDFVFGLCVGHFKLDKPNADCNVTNNFQGPLKLSDYHWHSEDDSVCPCKRSARDEFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDJ7</accession>
    <name>A0A9P4PDJ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_86673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDJ7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="140" mass="14998" checksum="A768018F485F8FB2" modified="2023-09-13" version="1">MRACYGQNEWQCMRSVAGADLCSSDGLHRDVDTRAPRIPLSVVVWERTPAMAPGESSPLGAATGEPTGPHRWALVLPPVLPWISSRRRFTSAVPRCLAHAYPPSSPTTSDPRLSLESDVLSGVAPGRRPLPSSRARSCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE11</accession>
    <name>A0A9P4PE11_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_414739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE11"/>
    <dbReference type="OrthoDB" id="3504488at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040124499" description="Alpha/beta-hydrolase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="36799" checksum="4CEDB552AB202DC5" modified="2023-09-13" version="1">MLLSLLILALPGQSASERPHKPITLSSTGGFTIGGRTIPAPSNPNLTLSCDHGYMEYFLPLRPRKTSLVMWHSSSTQVWQNTWSGGPGFKDLFLQRDYPVYLWDGPHVGRANWPCSPTLNLPTSTDATNFLAWNFGPSYKEWWPDVRFPTHDAAAWHQATSARYIEYETKANVDLHARAAATAADSGSAGTNIVYLTNSAAGLRAQLAATLSATTNIKAIVAYESIGFVYPDSANVTAGVGGFGPYVVSGAQFRKLAAVPAVLFVWGDHRGEGFGSLAESRRVAGLINEVGGNARVVKLGEVGVRGATHVPFADLGNEDVAELLEGFLEGEGLDGYVDGEGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEG5</accession>
    <name>A0A9P4PEG5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear envelope protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_523466</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEG5"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106166">
        <property type="term" value="F:spindle pole body-nuclear membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2441461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="71505" checksum="CF3781ECD29B63F1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEM6</accession>
    <name>A0A9P4PEM6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEM6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="236" mass="25814" checksum="38B495A1F02F6F61" modified="2023-09-13" version="1">MLSTLRFPLLQVVRSTTHTVPQAHIRDSMSAPQQQQQQQQQQQQQRGADPQSNENQLSVRSSQQKKQGEMRSSGNHRRELRRSLHTTENKCAYRPAAKCPSHPLPDPLYTPNHGAKNPRPLLSVGAGRSHSGAKIGSNPVRKQSRARLGAHRQRESALSCAALGLGWDDVVVGGSGGSWLGITCLGIYGGWLPADACAVGGVARNVISTFKVWDVRLVGESRGVLRDFVESMMVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEN3</accession>
    <name>A0A9P4PEN3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional regulatory protein DEP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_70931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEN3"/>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2442620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="75182" checksum="E635149B4523F220" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEQ8</accession>
    <name>A0A9P4PEQ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_445255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEQ8"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF53">
        <property type="entry name" value="BETA-1,4-GLUCOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040309859" evidence="2">
        <location>
            <begin position="16"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="716" mass="79882" checksum="F083E8BAD2130F4B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEU4</accession>
    <name>A0A9P4PEU4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_47206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEU4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="205" mass="22848" checksum="0EA7583CF91DA5BA" modified="2023-09-13" version="1">MLLGVWGCHDEAEGIRWQALGCQCKLPRKATRVVRDKPASQFGCGRHPRPLPKLRIVAVSRFRTPPQAPQTARSENHCIRAALSVVNAARLSAKRATAERTSGRPAQRWQWSNARYELGSSCCPDACSEASRQHAWSKLLDPRLHQAGTGRTTSFLIHSVALIPDVTPPYRSLQRLRRQHPTFPPTNASRTVHPGDQSARRAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF30</accession>
    <name>A0A9P4PF30_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_433588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2441993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF30"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2441993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="566" mass="61837" checksum="C239983F153EC652" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFQ7</accession>
    <name>A0A9P4PFQ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="5">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_417759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="5"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFQ7"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="7">
        <location>
            <begin position="728"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2442513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="857" mass="97996" checksum="01EAA6A024CB8DF8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG55</accession>
    <name>A0A9P4PG55_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_485908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG55"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WSC" evidence="1">
        <location>
            <begin position="84"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="277" mass="29992" checksum="BA81FF5F5C01C75E" modified="2023-09-13" version="1">MDSQVCMAICNGGGGVEGNKYAVIYDTDFCVYPATLTTGLLPNDCFMPCVGLLLGSPGQSCGAAGKSVYYARAEAQPGSQLPSGWSYTGCFQAASATVPAFPDYSDHNVVVVPAKSTTFSDNDVLKCIDYCTDDGYLVAGISNTNTCTCAKETQVTASTKCNLRCPKNDLESCGGSSSYNVHSSDAGFDEPGPASLPPDDWKSCHYNRAYHYDGAYHYDGANYYDRANHCDRANYYDGANYDNKSCHYIGTYNYDRANHYSSPDHNCYIKHKCTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGD7</accession>
    <name>A0A9P4PGD7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="4">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_416076</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="4"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGD7"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="11">
        <location>
            <begin position="127"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="518"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2442858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="572" mass="63027" checksum="F13C4BAE63E6A8F0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH91</accession>
    <name>A0A9P4PH91_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_473197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH91"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="739"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2443985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1271" mass="137099" checksum="485B8DD9B236CE01" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHG5</accession>
    <name>A0A9P4PHG5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_486146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHG5"/>
    <dbReference type="OrthoDB" id="3798501at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="144" mass="16273" checksum="87702AB3035CBCDA" modified="2023-09-13" version="1">MTPNNPTEQTQRETDVPPPVPPKDTTDDTRLRRRRPPPLTGAAVKPLPPPPPVSNVRVEQSESGIWNAPPRTREGIHFDQPKGRIGKPLPRIPWRPDYRRTFLWIGGLGVWFLLVVLLLPVFLEGDALPRLNRTLRSHLALLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHI1</accession>
    <name>A0A9P4PHI1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">VHS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_494516</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to ARF1 and ARF2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHI1"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000003">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="12">
        <location>
            <begin position="195"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="536"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="438"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2444256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="656" mass="71488" checksum="EED2FBF815B28456" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHM6</accession>
    <name>A0A9P4PHM6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_432747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHM6"/>
    <dbReference type="OrthoDB" id="5413281at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="186"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2443503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="286" mass="30155" checksum="68BC1C4BE57CC636" modified="2023-09-13" version="1">MASSQLQSTRMFVTQLVDALGVSASASASSERGAADPEARNGNRNTLEGAGGGVKKQMLALHVAFPNELLPALDLLDRSLVTRFRIRRDVEDHSEGAAPQGVRGRISEAHAEGTPGNKNTGGGIIDAPTPDAEMLDAPHSASSDDGAQTTPQDSEHDMMMDSVYYVRSAQQRSSRFSSSFDALTSYEVRLSAWNCSCPAFAFSAFPPVPVHPEPPVPTYEPDGGIHAEEGAWNFGGVGLGEGIPPVCKHLLACVLAERCAGLFGGCMEERVVSVEEAAGWAAGWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHQ3</accession>
    <name>A0A9P4PHQ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_391230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHQ3"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF2">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G13450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="259" mass="27648" checksum="6C581F326643BF5E" modified="2023-09-13" version="1">MPTILVVGATRGLGASLANAYKSDPNNHVLATARSADPPPNTKNLTYIPGIDIATPDAGKKLLDFVHTKSISQIDVVIITAGYFATESLKEPSFEAEEKMYRTCVIGPTILVTTLANDSDLLNSKSKVIFVSSESGSITLRHESEGGGNYGHHASKTALNMSAKLLSLDLKERGVAIAVVHPGFMRTELTRGVGFDKFWDEGGAVTPDVAAKSLVEWISTFDISKTGEYWAPRGPADIGTADAVLGPKDQLPTPLQLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHQ7</accession>
    <name>A0A9P4PHQ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHQ7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="421" mass="46614" checksum="46843BCAE25647BB" modified="2023-09-13" version="1">MQSSKAYGPTPFICSEGLIALRAIDTTIGKSPALRPVHAAKVQGELQGDDLRRRQSSSACFYSQFTLSAFGQGDCATILRAAEGCLRSAPRVLTFTWSFRQHRRGQPALKLAPQPQIQAPIPIQRLQQASSSSTAQSHDGRLTPRGSISISTTFLPNGRAVGDVRSANDLREKYGRIRDRYGRGVDSPGARGSSELLAVVMESITSKHAERGALHPTDDNKFAESGVSDVATSAGEYTTDDKTAEWLSQFLSDLQQHAYQHGADPSPASKETAIPASKQSDYESSSLRIKRQRRRRADSPRPRKASVTACDALSKNSLFNAPSHREASASRAAPRPSKPPPSTLQPPPPPTPEFAVWVGSFRYTFDDENAAEIFRRQQDDMEEQDRIAIEAEAEKARARRRESDRVLMERIWKIKNQRRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHY2</accession>
    <name>A0A9P4PHY2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF167-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHY2"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="119" mass="12634" checksum="14EFF953619E0076" modified="2023-09-13" version="1">MLPPAIRFVATKGSKTPTGSIQLLCRVKPGVSANREGVSGISDNAVEVCVAARAKEGEANKAVRDVLAEALKVPKSDVDIVKGMKSRDKTVMVGNIRISGTPEEYIERVKAALQERAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI10</accession>
    <name>A0A9P4PI10_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_454040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI10"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="263" mass="28561" checksum="5175B1CAAD752284" modified="2023-09-13" version="1">MAHSNSKRSSSSSSNHSDRSTANVRASAYVVNASSAALQGFHYSTTGAGGAECPPLAAKASSNAVGRARRGGAAYTITGECERLFCETLRAVFLGEGNLAQKDSLVMGMHNNMTTDIVNDYGINVRMNTSSATDAPSPEGFGWVQQKGLVSDWIEVWDYVGGIRFRGFVAEKADEKAMVVFFDQNVIGGDLKAGLMALLELCAIDYFACTRLVVCIDRHTQQKPLEVLSKDLGWIGFQLTTLREFAEQGDVISNEWLFMEMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI30</accession>
    <name>A0A9P4PI30_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_520236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI30"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="244" mass="26914" checksum="F19560EBFB59FA96" modified="2023-09-13" version="1">MRLRIPRDRLWLLPCIAGTAWFLTLAVMLLTWVGRGCPRYPGQQNPYIAFISDIAAFQLKPLFLVGSVTTAVGYTGTMLAVHSARYDRRMYSFFDDAAWKKTASVAATCAGVVAGIGLVLLAVLDTFRFHAEHAVLLLVCFVGLAGSMVLTTVVWWEQAWKPTPFRGLRIYCAASAVIVFLDAGMGFAFYTLMQTEYWRVSGVLEWAMAFTGATYLWAFVGFLRVPGEGGGGGDRQALLGETRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJZ1</accession>
    <name>A0A9P4PJZ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trichothecene 3-O-acetyltransferase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_34864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJZ1"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF270">
        <property type="entry name" value="O-ACYLTRANSFERASE AUSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="469" mass="52598" checksum="C422E0684C68B822" modified="2023-09-13" version="1">MYELQQHRKLSALDEMLPAFYYCYLLCFPVSSDSMASTSELLQMSLTSLAAERPYLTGTVQRDLESSVRKGHLILDIPNPFEDLRIVFNNLTDPGCKWRGTYHDLKDAGMPPHKLDANLLAPLTAGIGETRKVMSVQANFIYGGLVLAFCFPKPNAYGAGRIIARFSEHCNGTVDLRNGVDLARDRTGSRGIADVLDFQILKEQYKFEDLESDPMLWSLNCLEFRGVNDFRWPDFIPSLLSVRKPPIISSMFSFSSDALAEIKAMARPSQSGAWVSTNDALVAFLWRHTMRARFTSLITEDETPTRKSNVVVALDGRKALSISPNYIGNCLFHCFTELPIDMIASESTHLGEIAIKIRETITTARNETLLKAAVGLAATHPDCQTIKYANENLGPDLYVTSWVDLPFYRLDWGPLGKTEFFRIPDRQFESLCCILPPKDGVVQLITSMEEGHTKRLCSDAEFTRFAAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKA6</accession>
    <name>A0A9P4PKA6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_282049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKA6"/>
    <dbReference type="OrthoDB" id="3786627at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="168" mass="18869" checksum="5A03420B053AECD9" modified="2023-09-13" version="1">MTRKDLLKKAFRNNFIRKSVADLKSLGTEKAHPKPRHSSSTNLRSQYEEDAPVLPTPPMSTGDFSAHEDAIEQEHKVDASNLVAASETASSSRESVTEWLQTVPKDPAMMSSSEIRIEMEKVRIPLLSFREASKITRNRPTPITKPRFCAATSSCSATTVIWSWRPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKS8</accession>
    <name>A0A9P4PKS8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450 monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_431380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2446011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKS8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="630" mass="71400" checksum="53DDF15BE65AC6CE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKT6</accession>
    <name>A0A9P4PKT6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibroin-3 related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_471357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKT6"/>
    <dbReference type="OrthoDB" id="5401332at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="50977" checksum="F2F6DB4869A21562" modified="2023-09-13" version="1">MASTLVMRSLLAARNPLDDAKDTLSSWDKCMAKNYCKWPVIVAIIVGGIIVLSVVLCIARCVCCGAELACCCFKCCSCCCPSGGRSGHKRVKTPPPRPYDASAYSGGLPPAPVPVPMDTRPPNQQYRSHAAPTFNPAPAPTFNPAPAPSVSSYNTAPKPDAPQFARFDAHAPPANEDALPAMPSWRDARTTHVEEEYIPEKRDDVEMDRLDQNGSVAGTSMAAVAAGGAARRSPGPARSPVQRIQAEEGYGYPQGYQDGAYANNAPRRSPSNAPSGYSSAYSQQADGYRGASPVNQLLSSAPPYGTGAGYAQNQQYDRRSPGPGYNESPRRSPGPGYDQYGQYDQQQSQQYGQQITTRTPPPLNTNNYGYNNNNTQYSPREVSPITPGNGMYNNGVPAALAPGRNPSPVYAPSGSTRFEPPAPSGSPAPAYPGQQTYGSTEASQPAYTPYRAYTPAQTQDPYSGGVSRKPVEGSWKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKU1</accession>
    <name>A0A9P4PKU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_280444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKU1"/>
    <dbReference type="OrthoDB" id="10493283at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="171" mass="19009" checksum="0D3E27E971496D1C" modified="2023-09-13" version="1">MCRSARAAVRSYNMSASRGDKPLSSCGIVSVHFAFTFGSVQVVKLPVILHSIRTTGKLQRRLQNLDRRTTHISCFSLPAAAMFTLKQRKSKPQKTPKNPRALDIAKTVLKYIAIWVLAPILLGFLAMLAILYFSNDGLSKSPVMGVKVTQSDWVQRNWIGNTTQRGYAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKV6</accession>
    <name>A0A9P4PKV6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_251464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKV6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="106" mass="11475" checksum="46421498D506CDF4" modified="2023-09-13" version="1">MLTSSLLHSITRRPHAIALPMAPCPKGKHSRPAAVFHHTIQCEPACSHRPSVGRSLNPILHTSSTRNLREYEGQEAVGLGLNPGSRAGSVEERRGAARLRVIPNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL67</accession>
    <name>A0A9P4PL67_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Cyanide hydratase</fullName>
            <shortName evidence="7">CHT</shortName>
            <ecNumber evidence="2 7">4.2.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyanide-degrading nitrilase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Formamide hydrolyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_359676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>formamide = hydrogen cyanide + H2O</text>
            <dbReference type="Rhea" id="RHEA:21720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16397"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="EC" id="4.2.1.66"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Oligomer of dimers, forming left-handed helical fibers.</text>
    </comment>
    <comment type="induction">
        <text evidence="7">By cyanide.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.66" evidence="2 7"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL67"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030196">
        <property type="term" value="F:cyanide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019500">
        <property type="term" value="P:cyanide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000011">
        <property type="entry name" value="Cyanide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03224">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037544">
        <property type="entry name" value="CN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF4">
        <property type="entry name" value="CYANIDE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2445188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="366" mass="40414" checksum="0088EAFC2778DD8F" modified="2023-09-13" version="1">MVLTKYKAAAVTSEPAWFDLEGGVRKTIDFINEAGAAGAKLVAFPEVWIPGYPYWMWKVNYQQSLPMLKKYRENSMAVDSEEFKRIRRAARDNQIYVSLGFSEIDHATLYLAQALIDPTGEVINHRRKIKPTHVEKLVYGDGAGDTFLSVVPTELGRLGQLNCWENMNPFLKALNVSAGEQIHIAAWPAYPGAETLKYPDPATNVADPASDLVTPAYAIETGTWTLAPFQRLSKEGLAKNTPEGVEPETDPSTYNGHARIYKPDGTLVAKPDKDFDGLLFVDIDLNEAHLTKALADFSGHYMRPDLIRLLVDTRRKELVTEADPNGGIATYSTRERLGLNAPLGDAKKRGPVGVAGLNDGLDKQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLD4</accession>
    <name>A0A9P4PLD4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_248149</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLD4"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="308"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="967"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="972"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2447235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1055" mass="116408" checksum="BBD170F20444F84E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLU8</accession>
    <name>A0A9P4PLU8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_429128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLU8"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2447489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="598" mass="64894" checksum="1D573F4B71C98176" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM24</accession>
    <name>A0A9P4PM24_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_431032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM24"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040439094" evidence="6">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="105" mass="11384" checksum="31B0B853B5D90EC4" modified="2023-09-13" version="1">MRNGSPYLLQLMLILASAPLLSASIYMTLGRLVDAVCGERAHCCTEYISVGGVSGGDDRKLYTTEVFLYAFDASLMFAVVIISAAVHPGMLLRATRKKERGITLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PME5</accession>
    <name>A0A9P4PME5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_453274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PME5"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47701" checksum="96C60ADFF92F95AF" modified="2023-09-13" version="1">MLTDDLFKGWLSVPEIDGFLDTEAPNQQEKASVPSCPAGNNTQRSLRGENGLNSTERLSRQLDRPRLGKFDDSCLHLPQVGPSPSDTTCAEPDIPRFSHQYEYLMHGMLAIAGSHLDLFSDDPRSDIALLHRQKAIVGLEEAFTRWPPCADEAHVMLATSYLLAFQSSYLPDGLLDHILSLRGCALLSQLILTDQIKGVFTIDPGIAPIIARLAEILRPLLVSTGLQGPPENARPAVPEYTEPTQPSTANQEKHPSVSFPDAATNPLFPAKLAPNFEDITSWETITEVPVNQQPDLRRSFQAFMLSLAILTTWPREQVLALFSPKNSLGSVLVAHFCCVRFITSPFWAPDSALRTTPMRAIVEWCEKAVDAVADDEEVEWTKFVRWPRKILTTMRCLLGQSSGLTLGQLHDALCKDAAAFREGRPVRLEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN58</accession>
    <name>A0A9P4PN58_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_484526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN58"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2445871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34763" checksum="0D0CD97548ECA741" modified="2023-09-13" version="1">MNTLHAKISGLFSTRKYYQLGTESLLNPKEGDYNEGESERSLEDSPLQGRLLPHRRQFLILTISLLFFVFLSIALAGAYALKRTSDRDCGIQTGVFSPANEAVEYLEMEFDNAFAHDTIYRGPPTPDLERAWEDLWYYGGVRITDDQLPLLNRTPDLGNGRRLKPVGDEKGGYHALIEVFHQLHCLNLIRQYTWKDWYFRHPDVVRTPPDVRTDEITARMHVDHCIEALRISLMCHGDTTPYMVLNDPTAPNNMRADFSPHHKCRNFDSIKEWVKENQLAPPPPTNWEGRKDGKQWEHGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPG7</accession>
    <name>A0A9P4PPG7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_509235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPG7"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040245907" evidence="5">
        <location>
            <begin position="21"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="967"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1228"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1263" mass="139929" checksum="31D471CBE933DCB0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPK0</accession>
    <name>A0A9P4PPK0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_471007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPK0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="260" mass="29173" checksum="E72953AAE6115F3F" modified="2023-09-13" version="1">MSMISSDQRRLRPRCGFKCYSPSRTYKHPIAHYDQIIDDKEEFSKLESRRVNFKQQLGNNAWTQSTQLRVVIALVKEFILIRKQSVVILSNYLCTLDALGVGLRTASIVAARFDGTIGTEQRQMAVFKILWGVAEEGPRSAAMVQRKVPRRTGQGKTRGRTSKEQPRRRGWWGASSYAFTAHIPCQLGPHDSPRQNHLGGKTTGRGSRTNVSNRGDESKGGSVGENGVEEETTPNDGLEMEEEQVWKEIVEDESTCSSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPQ5</accession>
    <name>A0A9P4PPQ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_222973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPQ5"/>
    <dbReference type="OrthoDB" id="2823490at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="348" mass="39895" checksum="72C32CE372E4B509" modified="2023-09-13" version="1">MPHLMVIPREIRDLMLELTVLASRPAPETLADIETQALEEQHQYVYYSTDCLDCNRFAAVPLLLVSRQIHRETKQLLNRIGNTHELDVRFVHEQYFVLTWTRLPLSVHNVDHVCVVFKSVGEYRDSVEVCGRPIPNLWRSSRGGRPAQFQLMFYDVLMSFLINGPYGWRASRSAKTEGFTIRTLEVDFVDPDDTSLLIPEPDDPKTPLHRQGGKGLRRPERLAKCLGQLLASLLTTTVHQYGKGIFDKVGRIIIKANGKMVVGIKVGQILADYDFSDSFVEVPKGERLDHWKAWKDHALLCREAKGLDVSDTRLDWKEKAVFGFARLQERYQRDKMEKISSASHAHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPT0</accession>
    <name>A0A9P4PPT0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_243904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPT0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="299" mass="33552" checksum="3AD70AEC67CDE6D8" modified="2023-09-13" version="1">MGQVEARTRSGLCHLEVEHATTRLHSISVGLTSRKVALRPARWFRPPFARSLVATIRKAIQYLTRPSTYLLHTSLTAQNHPPRPSLILIRVHPNRTITSAKPLIASSQHVGRKAPFERSTTFQPGKAVVDRRTKVYMRAAALHANSRLHMRSNSRQNKHKRTETEPTTAAIHTPRSTPSLTPAVPAQMLACLPACHALRWMRRHPHLELPSSRLRVHALTLPPGSPISFSSHNLKPARCGLVDGDCEVWLGLALGCGLVLRWCRRSRVKGLGCCVMFVGWLTWWREVVYVGVQVGYRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQB6</accession>
    <name>A0A9P4PQB6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_242046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQB6"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="73794" checksum="B93F8F1914A75CFD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQH6</accession>
    <name>A0A9P4PQH6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_442315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQH6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="179" mass="19380" checksum="C9554D74F9F62388" modified="2023-09-13" version="1">MSTSKALEELQTVSPPSHDPMRNTNPSKLARVLKHKALRTPGKIELLLSPSSNRLPPLTPPATEKPYRETAPTTAAKSTNRKTSEDYGPDKPEQPGTSASSTYVLDEAKAAANDDLTRRRGRAREQMTALRNERKAMKDGRGSGIGVVVAVAVLVLTIAVVVYIVAVKHAQYARLGKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQZ7</accession>
    <name>A0A9P4PQZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_216887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQZ7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="124" mass="13272" checksum="68273E9F8C5EF3AD" modified="2023-09-13" version="1">MEHGAQVDASALDRNSPAKRITYRAPLQPPVLPSPAIPPPPAIPASVVPHGPTWKSDHDIEMAALKSPHARDMRACTVPARPCPSLPVPARLHVAPSVRLRLRLRLFPADPSCVSSNAPKSPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR68</accession>
    <name>A0A9P4PR68_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_509787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR68"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040535242" description="Pectate lyase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="247" mass="25067" checksum="677FB86DB05B6DFD" modified="2023-09-13" version="1">MKASVAAAILAFTASASARSVFTKRADFPIPASAGTTTFNAPEEITGTFDGGLKTYGRGVSCSGQAEGGDSDAVFILKDGATLKNAIIGADQIEGVHCEGSCTIENVWWAAVCEDALSLKGDGDATIIGGGATGAEDKVIQHNGAGTVTIDGFTAVDFGKLYRACGNCKKSAERHVIIKNVVSQSGKLLAGINSNFGDTATISGTCATGLKAICTEFEGTTPGNEPAETSSGPSNACIYTESEITTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR93</accession>
    <name>A0A9P4PR93_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_200519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR93"/>
    <dbReference type="OrthoDB" id="10478495at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="352" mass="38842" checksum="27A0135E9B889135" modified="2023-09-13" version="1">MSAPTHNTTASNKPSAAPPAPVLKFPTMYGQKKGKVSATRRSPLRSTMTDTLPTQTTPLFASFSNAEQPVVPTAAPVSTQLENANREAANAVTPTAVQRYGDTVRISRAADKFREVANWPLDKRLAFLQGPTIDVTCGTTNFTVPRGLMTWASTTACEKNENDELTALDVNPILVAGVQRLLHWLPTSLSKHRPYGLASVDDDAKALAIDNEVVCAGEALGMHAFVHKLRGFWLQRLKSMSVEDMGFERLKILEDRISDDFDCTIALRVIRTKALAYVYEGNEPARIQLLEWLRQLPKMQARFSTVVDEIEQQHGERRTMASCAQHKRVGQAFGCSGVDGIFCVRYGEGHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRW6</accession>
    <name>A0A9P4PRW6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_482085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRW6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="195" mass="21367" checksum="E1B7C68403413704" modified="2023-09-13" version="1">MLDAKGAISERMSEPLNWEKRLGHLLKCTDYVTPIVQPVPIARDSNLHDKLVDLSSIRGSLSHNSPTGLDTFSITPSQHARNHIISSKGSTLDDRATRASSVPTFALQTSPPGSTIDVPTGSTGAHPRSEFEGSSSGSLQRKRKSNDDESEYESFRAENDGKRRRAKNTGQCDTGEALWKSDREEFMPPPGSQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS12</accession>
    <name>A0A9P4PS12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_428378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS12"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="356" mass="39093" checksum="5177236859B4864D" modified="2023-09-13" version="1">MAKENRGLVAITGANGTIGYACTVYALRLGYRVRCVVRSEDAIQTLKHGPSLQQFASQIDYHTVPDNTVPDSYDSALADVEYVIHVAGVWPTPDKHPDHDIYIPFVKSMQNILSAAEKLYTVKRIVFTQAGAAMVHPDDGDTLGTAMDIALNEYTPVHPGLLNLTPPLASPHHAYCAAKAQCMTTLKNLRASGKVPFSIVQIIPGTVMGLSELVSAKTDGRKHMDRMSRALLFNEPKPRYAFGFVNVGDCAKIHVEALDEVKVPYDEVPDWFIAAGSSDPSKGGEATWKEAGDLIESTFQDKVASGLFTVGRHNVPINMPYYVDSALTETKLLRHEKFKGLNECVNEVAEWYRGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS13</accession>
    <name>A0A9P4PS13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 88 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_378799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS13"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000048">
        <property type="entry name" value="Unsaturated chondroitin disaccharide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="464" mass="51924" checksum="FE32656E244DC67E" modified="2023-09-13" version="1">MGEAPKPAREAANALKVKGIDLSQIYSENVLGKIVQVAQKGSKLPAPLATYPHTVAQTGPDAGRYEYREADFWTCGFFPGSIYTLIERSIKYPRVIDVPSHPPAQLKDQLLNLGRHWSAAINQMSGRTDTHDMGFIVQPALQKDYESTGNTESLESVVKAAYALASRYDERVKAIRSWDVAINDRYSITDMDENFLVIIDSMCNLDLLYWVGHIQQDERLIQIATQHADTIIHEILRSDHSSYHLVNFSPKTGKPQAKMTNQGHKDDSTWSRGQAWSIMGFAQTYTWTRDTKYLFTAIECAKYFLRRCEEGKGKWHHPLVPAWDFDAPQEDEKEPLRDVSAGVITANGLVIIHQALQALSAEEAQKLAGSDTDFLQVALAIVDETLDMALDRDFASVESQATVNGDGAANAPLAVKESGFEAILRHSTANHNEHAHKPYWDHGLVYADYFLLEFGNKLLRAGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS99</accession>
    <name>A0A9P4PS99_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_319517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS99"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="257" mass="27085" checksum="D355BDC7179D7AA2" modified="2023-09-13" version="1" fragment="single">LTGLNRASTTLLNNKRSKLRASITRICRTFKDASKATQEQLLRSLDATLVFAQEEAGTAVCISPSGLLLTCSHCIADDAATALDPSNTHWLIFATGVVVRATCVAWDPKRDLALLQITDSEPLSPPPSASTSPTSSSSNTTFPHATISPASPPLTYPLVCIGHPGSEDLEAPTPGTATGYDVLHVSEGAYYGLSPGQDPQDNSDIGALMHDCWTYWGHSGAPVLDGRGGGLVGLHSSWDDETGMRRGVARVAVISFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSB9</accession>
    <name>A0A9P4PSB9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_189674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSB9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="166" mass="18299" checksum="C22D17CF0EBFCE62" modified="2023-09-13" version="1">MQRSSRALRTASRSPAIHTLRFLIQMSSPMAPYPYSYLFVSTIPKYRSTIILLFACKRGPNNRPLCGINLQLRKKPAYPPLQHSTRDWSSQTEGSIVHAACKKGEPPTPIEGEAGVEEKKTESCPSVADCGGSLVNADRDEYATTGAPKKGKTDRMSNRSKTFGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSF9</accession>
    <name>A0A9P4PSF9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_462074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSF9"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000882">
        <property type="entry name" value="Translation initiation regulator (Gcn20)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="201"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="533"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="762"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1224" mass="134490" checksum="3DFD2C4E134D77C4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTJ4</accession>
    <name>A0A9P4PTJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTJ4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="66" mass="7484" checksum="892A8EF0C59C47C5" modified="2023-09-13" version="1">MHGNLYIPLLLVRLHLLFLLALSHFTSSGIRQKKAGFSIGPHRFELVLELVWILESMDSGYGSGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUN7</accession>
    <name>A0A9P4PUN7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_188503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUN7"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32062" checksum="1CBA8C463B821D50" modified="2023-09-13" version="1">MRSIVKNSARLDQIMLGGIPAKEGWLSWVPDWRLPYGRHHVRYLRSRQASGDLPAKIRFFGKETHGNLLSCRGYQVDTVDGVAAGHSPPCHFTQSKNASNRYSNRISEALQQTLLMDHPGATGKLLLEVPWTLTCDTDTSPANFCSSQEWLELSQSRYFQKFHEFRRHNEDFCIGGQSFRSFFPQSGSKSVDISITLRCLRLALLSLDQRALITTRTGYLGLAPTAVRPGDVVAILLGCKCPMVLRQYSDNLYHVIGECYIHGLMDGEILSQVSGGNILEREVVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV06</accession>
    <name>A0A9P4PV06_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_378145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV06"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040270889" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="11">
        <location>
            <begin position="393"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2450795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1013" mass="111050" checksum="7F12B453893EC127" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVR7</accession>
    <name>A0A9P4PVR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_136270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVR7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="59" mass="6309" checksum="FBC0B5424A8C40D5" modified="2023-09-13" version="1">MSVIATAVRLTPIGFVLNTILISILLSQVSIREGAFITNHPSLTSICVYGNRSSLGICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVT3</accession>
    <name>A0A9P4PVT3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_480878</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11 14">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="11">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVT3"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517:SF48">
        <property type="entry name" value="PEROXIDASE 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 14 17" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040528430" description="Peroxidase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="76"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="55"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="72"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2449819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="314" mass="32183" checksum="56F56EDEC1B3E04F" modified="2023-09-13" version="1">MLLHSAILFTLAARAVAGASGSSNTSPSSPSTTSSASNSSSSGSSSTGSPSSTDCSTWSKVASDLSSTFQGCGPAARGAIRAPFHDCINNGCDGSLILGSECSRSENAGLPPTCTLLAAKAKQYNVGTADMIQFAAAVAIAVCPLGPRVRALVGRTDSSTPAAEGLVPSTKDPIAQILRQFAAVGMSAADVVALVGSHTVATQSFDDPSQAGKALDSTPSRWDVKFYSETKAGTAPYSFSSDRRMTNDSSTEGSWDRFARSQHAWAVAFTSAWDRFVVVGNDVGKLKDCSSSLPGSSKRRAEGMGSPMGDGAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVU4</accession>
    <name>A0A9P4PVU4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_459319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVU4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="49"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="531" mass="57867" checksum="4C2BF1026E55F294" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW36</accession>
    <name>A0A9P4PW36_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_4387</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
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    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2451350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="121" mass="13019" checksum="803EF7F533751D5F" modified="2023-09-13" version="1">MAAIGSLVFCTDCGNLLDGGAGKQNAILTCQVCGASCKDTSLKTIVTRSKPDAFPSALRTKRSEVQSVDDADIGGHATIAQTCEKCGREEVRYYTQQLRSADEGSTVFYECECGHKWNTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWA2</accession>
    <name>A0A9P4PWA2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_426868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWA2"/>
    <dbReference type="OrthoDB" id="3515051at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040439515" description="DUF8021 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="2">
        <location>
            <begin position="151"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="263" mass="28683" checksum="25F97A047329A127" modified="2023-09-13" version="1">MLHTIALLAALAASATAHCTRPLLQEAVDAYLLAQTTGETTPFTAHFDNSTWLGYRENSLKVNITSGIIATPLAITHNRSFYDTSSCATFTEVVVNSSTTPYVIGTQLRFTNHKINKVDSIVTKPGDWLFNITGYAHWTAQEKWDPIPAEKRDTQLTIRKAADAYLDVFNNKNVTVPWGTPCVRLEGGLYGDAGPNGTCAGGVPSGVPLTNRRYVVDEALGSVDVLLDFGNSKWPDSHLFRVEGGRLRYVHTLTHCGRANCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWR2</accession>
    <name>A0A9P4PWR2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_516150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWR2"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="410" mass="44097" checksum="1BC5F8EA40425A4A" modified="2023-09-13" version="1">MAGPNPRSYDLVLYGATGYTGDLTAQYITTHLPSDLRWAIAGRTLSKLNTLASTLAILRPDRPPPAIVTVEHTKEGLSALANTTRVLITAVGPFHRYGSVVMEACATTGTHYLDSTGETPWVYEVAHKYHDLAKKNGACLITQCAMDSAPADLAAYALVRFLREKCDAGTKEVVHSIQEWKNGMSGGTLHSLVGVAGGYPFAHLKESIKPLALSVDGVRPQSKPRSFGLSGTRREEEVGLLTDSVIGISDTGLVYRSWSLMEYGEAFSYFTGMKAANRVSGFLWHAGLAMSLPMLLISPLRKMLTSVLPSPGEGPSEKAKARDRTSWQTVAFCDNSSAQKAVCEMEYSGDMYSLTALLLSEAAMVLLQPDGENWAQKLGGGVLTPATLGDQYVERVKAAGLSMQTTLIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXL1</accession>
    <name>A0A9P4PXL1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_19000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXL1"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2452102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="747" mass="84154" checksum="2AA4979E6FFA0F45" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXQ5</accession>
    <name>A0A9P4PXQ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_427110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXQ5"/>
    <dbReference type="OrthoDB" id="3643156at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="158" mass="17097" checksum="C95CA66319BDC56D" modified="2023-09-13" version="1">MRDPSSLEQTRPRTRVCNAVANLQIEVPRFDIPTPLSCLPPAALGTRICFAALVVDDREGGPYRKAAATALGSVGLANVRVTRGKRYRAGSPCLPFFRFEVDDVASHSLFPIVDAQVALMEPLPADDEKAGGARLAHGPDCLRERIRHVARAGRPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXU5</accession>
    <name>A0A9P4PXU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_403615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXU5"/>
    <dbReference type="OrthoDB" id="3486565at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF15">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="187"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="546" mass="61485" checksum="98444E0C51F4EB53" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYW1</accession>
    <name>A0A9P4PYW1_9PLEO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_438510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYW1"/>
    <dbReference type="OrthoDB" id="3799304at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="661" mass="74043" checksum="866A7169F7F22581" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZS4</accession>
    <name>A0A9P4PZS4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_493903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZS4"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267:SF1">
        <property type="entry name" value="BILIRUBIN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267">
        <property type="entry name" value="CUPREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        </location>
    </feature>
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            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="411"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2452193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="608" mass="68029" checksum="D954775E2B5E8312" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5I7</accession>
    <name>A0A9P4U5I7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_172208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5I7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="195" mass="20686" checksum="65E51A46B788D93B" modified="2023-09-13" version="1">MGFAMTGTPATVSAASAGRWEEKRGAGGQERAALVVVSSTTSLRQFARSTLPAGGQALATPPSTPMRRLTPLPGRSESRIPTSCETRFRQPWTHRVWLSLLSCRRAAAKPLSQARIRCCAGGTCSANPTRPRPASPAHSLPSPLSPASSTPCSAKLTPTFFVRPRDARYRPTCEARSVAPSALLYAPSNQLSGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U644</accession>
    <name>A0A9P4U644_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_457599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U644"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000095">
        <property type="entry name" value="Triglyceride lipase-cholesterol esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="136"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="460"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2439714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="721" mass="79550" checksum="F6C026D7E3FFEFF2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6A7</accession>
    <name>A0A9P4U6A7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_491768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6A7"/>
    <dbReference type="OrthoDB" id="3761573at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="213" mass="23750" checksum="99ED4DB16C8FBDBE" modified="2023-09-13" version="1">MPRLNTWIKTRVLTLIKPRHHKKLSTKDINISKPIPSSLQHTGWSPVMRSPPQPCSRWSVSAEDLLLGSHSPSPSGSSTPSLTHSRESSDASGITIVVHSPPPSTPPPNYFPEELPLPTRSHWVEASPVRTIILPASPPVETLLFSETPSPTSYFKSAFEFDIKDLMCADSVLSEADSTDMQRMSVVEKRRLTRRMSLGIDGLRPSCWEYNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6X4</accession>
    <name>A0A9P4U6X4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_458690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6X4"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04396">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="81"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="969" mass="104752" checksum="76CD3E48CEAD5ACB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7W1</accession>
    <name>A0A9P4U7W1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_365643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7W1"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000089">
        <property type="entry name" value="NIF domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="273"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="465" mass="51818" checksum="85E31D2FA594D3AA" modified="2023-09-13" version="1">MVARRADGASYTQTDATAPDFDEKTPLLHPAEEPFPATQKPNRWLIPQRISDVFIGGVKLLLTPIVVTGHYLVACFHYEDGRFSLIAPVYHLSHPFTRSRRKKRTVATMHASDSSDTQEKGKRKGRSITATQKVKKPPKRSPSVISTSTAISSDSDMESERPSSRDGDYDAPSRHTRSKSTASSAGEEIAPAKRQIRIKLHNDEALRQRKAAKKTGAKGGLTQVSTEAANALKSPTGPITSKQLTKFPRAPQPPRPLVPRRQPSYSAANTASVGPHQKTLILDLDETLIHSMAKGGRYTTGHMVEVKLQQPVGAGGQIIGPQVPILYYVHKRPHCDEFLKKVCKWYNLVIFTASVQEYADPVIDWLETERKYFAGRYYRQHCTFRNGAYIKDLAQVEPDLSRVMIVDNSPMCYVFNEDNAIPIEGWINDPTDHGLLHLLPLLEGLQYVTDVRALLALRLGQPQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8T8</accession>
    <name>A0A9P4U8T8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 7">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_466027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 7"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8T8"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040476616" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="321" mass="33910" checksum="825F3391CBA111D3" modified="2023-09-13" version="1">MKSSILASLMGLAALVKGYANPLACSGVCGNAHDPALIRRDSDGRYYRFSTGGKIAIHSAKAITGPWTYLHAAIPAGSKINLAGKDDLWAPDVSKFGNTYYLFYTVSSFGTQNSAIGVATSTDLDNWTDHGATGISSKAGSAYNAIDGAAYFDGSNIVMSFGSFWGDIYNVKMNNPPLTVASGASSTRIAYKPSGTHAQEGAFITKNGNYHYLFFSVGQCCGFDASKPAAGGEYKIQVCRSSKATGGFVDKNGVSCTNGGGTTVLESHGWVYGPGGQGVFWDPSLGAVLYYHYVDTRIGYSDGQKKFGINKIDWSSGWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U911</accession>
    <name>A0A9P4U911_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_51941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
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                <person name="Bluhm B."/>
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                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ramirez L."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2443946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="36943" checksum="ED880B4D2FCE7746" modified="2023-09-13" version="1">MSTMFGALNRFISRLDAAAEDQNSATKGAYGFQVLRNKNPEVPLDPWFDFIIGINGRTLDDPDPNLFATEIRNCAGSPISLGVFSAKGQKIREIYIPIPAENPTLGLSLQWTPLSVTEDVWHILDVAPNSPADIAGLLPYGDYVVGSPEGLVRGESGLGELIEDYINRPLRLFVYNHEYNVTRPVTITPSRGWGGEGALGCVLGFGALHRVPAGLEEPPPAPGDTLFSTGSASFDEKRPASSADDLPPPQAGAPAELFVPANMALPSKSPPPGGAPKKGKQRAHHAHLNPSGGGGLDDYFKEGEQKSAEQGFAPKREGSVPPPPKVGGPPRGGPPKSATPVQNEEPAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBI0</accession>
    <name>A0A9P4UBI0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane-associated proteins in eicosanoid and glutathione metabolism</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_432302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBI0"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2444245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16889" checksum="B828DF90D0CC41E6" modified="2023-09-13" version="1">MTSFPTSRIGLNLTPATASWAVPFAAYYMFLQNRIVYHRLSTKTYFGDTIDASKGTEDSLYVCTRAQQNFNENIPLTLIIAALAELNGADRKYVNYFLGAILAFRISHVELGLMRPKSMGVGRIIGYYGTQASLLTMSAYLFYTVKDYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCN8</accession>
    <name>A0A9P4UCN8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="19">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">P171DRAFT_411244</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="19"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCN8"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000001">
        <property type="entry name" value="DNA repair helicase (Rad3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF2445416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="792" mass="90069" checksum="F15442F81E854E29" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCQ1</accession>
    <name>A0A9P4UCQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_32053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCQ1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="167" mass="19527" checksum="DC77081DE4C81780" modified="2023-09-13" version="1">MQRIPTAHLNLISLPPLNLTTHPPPRRLATTKQDSRNKAHHHHLASCPLRKHPPSTSPRTHAHPSSLLSHHHRHTHRHHVLHLRRQTKPIPKRNPRRLLPPQSPHLIRSRRLSPTQRKSLVCIPKTGKEKRSIYREAPWSGRLDYERIYLMVCATVLWYPTFPTSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD16</accession>
    <name>A0A9P4UD16_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_412871</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="464"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="774"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1255"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="144"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2444923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1460" mass="164609" checksum="E1B5419E4A2C809C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDD2</accession>
    <name>A0A9P4UDD2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_482428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDD2"/>
    <dbReference type="OrthoDB" id="4451586at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="934" mass="103616" checksum="DA0BFEDC7636EA2E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDW4</accession>
    <name>A0A9P4UDW4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_209647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDW4"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="128"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="334" mass="37547" checksum="4FE2079157E4DE20" modified="2023-09-13" version="1">MCRPGFRTFESAFRSARHSAPFRPTKQAPFRAYRQVRFGDKSPQHGRTAFASNLFRRWAARPTFYRDVGLISLGTGGAYVYNLEEVPISGRRRFNIISPRIEAQIGAATVGEVQQQYQGQMLPEWDQRVRSVKKVLERLIPFAEQAGLHDVEWEIHVIDSPEQNAFVAPGGKVFVFTGILPLCQDENGIAAVLGHEIAHVVAHHTAEKLSQAPFVLLGVLALMTFDLSFQLSSAVLNLFLSMPAGRKQEAEADQIGLMIMAEACFRPEAAMEFWHRMETAGGSGPPELLSTHPSHHNREEKIREWLPKAHEQAELSECHATSLYAQQFNNFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEV8</accession>
    <name>A0A9P4UEV8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 690.94</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH12</accession>
    <name>A0A9P4UH12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic binding protein-like II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_219490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH12"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="113"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="337" mass="37572" checksum="065E853BCEE1D1FE" modified="2023-09-13" version="1">MLALRLRTIAPTFRQARSFSTRTSAMAPLRIGFVPEHFSTPLEFAKKHYGLDARLLPFPSGTGHMVTALQADEIDVGVGLTEGWIAALGKAQETKQDAGFKLVGTYVETPLCWAISTGAKRDELRSVNDLKGKTVGVSRIGSGSYVMSFVLADQQGWLDPQASGRPFPVEPLNTFLNLREGVNNGTADFFMWEHFTSKRYYDNGEIKRIGDIYTPWSSWKIVAKNDLVNPKNWSQGDQASHSALKEELDDALQKINKGVQHFEDNQEEAVEYISTKLDYSEEDAREWLKTVRFPQEVRGVDEVVVQKTVRILQKAGVLGEAADEQTMTGLRRGGNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIC4</accession>
    <name>A0A9P4UIC4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_516107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIC4"/>
    <dbReference type="OrthoDB" id="10605862at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="319" mass="34411" checksum="1C038A535E3473F4" modified="2023-09-13" version="1">MYKMSAAGNTILQPRRSQADIKAIMAITNLVHLNRQGRIPTAHQLARSLDRTFCRLCNVWFRSDNLGRHKKTKGHDKAIRQAAEAARLTTGLHIILPPKTAPAANVLETDLRAVDSSAPAKAPAVEALEGEQSGEVVPMVGTASANADSGMAHIQTWLDAVAEAGSPTADASIMEVTPDVTFETTSIVKVPTGEQLEADVPAPSPSSPKVTETARRSFATDAARKTVASKGGISKPKSLKAVKSPRKKSVVVFTEEEDEQILHGYFQQIPEKETAKTMQGKSASAIKARIQVIAGLKWVPGGDTQTEVYYRILKQYHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIC7</accession>
    <name>A0A9P4UIC7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribulokinase/uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_516796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIC7"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="240" mass="25493" checksum="7C6418E1060E77A7" modified="2023-09-13" version="1">MAQNTTTPAAGSLNATILHLATRVEALLARQQASETPSRTLVALAGVPGSGKSTVSAALLAELAARGIADVAVVPMDGFHLTKSQLSSLPNPEEAFARRGAPFTFDAPAFLSLVHSLASTPLPTTPAPDSLIYAPSFDHALQDPVVNGIPISTRTRLIIIEGNYTLLDEEPWRGVAALCAEKWFVDASREVVLERLVGRHLAAGIETDARRAVARVEANDLLNGEVIRARLIRPDVVVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJI8</accession>
    <name>A0A9P4UJI8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_21514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJI8"/>
    <dbReference type="OrthoDB" id="5388207at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="216" mass="22871" checksum="DC44AC95954FEA46" modified="2023-09-13" version="1">METITNVVNSVSATATKAIWGEPQNNETAGNEPVSGLQGKGTATEPYDGGNSEDPALPTTQNETAGKEPVSGLEGKGTAAEPFDLGNSGTWLSTDTLSYSRVALLTHSCAQRTLPTLPLSPSARSQRPPRQPTPPRSPYDLTSPTQLAWLAPRTSPTRSLRPTSQTPRPTPASRRRSFPLARTSPRLQASQKTARSIPRTSPSVPSKSPTPPLATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJN1</accession>
    <name>A0A9P4UJN1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_425992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJN1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="8249" checksum="6E6FB0ED3859E727" modified="2023-09-13" version="1">MTSPRPWHCVLPRAVDSLPWLHVRSNYKQLRGGVRFVDELPKNAVGKILRRELRNEAKAEEEEEGVVKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4U0</accession>
    <name>A0A9P4P4U0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_506358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001517">
        <property type="protein sequence ID" value="KAF2437262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4U0"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="301" mass="32798" checksum="5C12944583B78790" modified="2023-09-13" version="1">MSLAQLVSFAPKFLYSQLFVRLPWPKSDFTGQTVIITGSNTGLGLEAARHIVRLGAAKVILAVRTVSKGEAAAIDILETTGAIKNVIEIWQLDLSSYASVKAFGSRIWSLNRLDAFIQNAGILTTNFSVVEGNESIITTNVVSATLLALLVLPKLRQTATRFNVRTRLSFNGSDLQYIAKFKEADSSGSLFDALNRKEGVDMNDRYPVSKLLLLYTVRELAARSPLTPESNVIITYFTPGACKTEIFRQEKGWLEAAAIQAFNTLVCRTVEVGSRTVVYSVDPGLGIEAHGAFLMDNAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4W6</accession>
    <name>A0A9P4P4W6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_182393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4W6"/>
    <dbReference type="OrthoDB" id="10577581at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="189" mass="20463" checksum="A4EB5EC439742B21" modified="2023-09-13" version="1">MTGADAEADRLSDVCWRGMRSVDGGGCSKRANRQKSGSKEQRAASNEQRDRSERASGGRDTAGSYGARDGGRPFWEFTQARGGAAATVASPSRARWQGAGADSVLRAGYQESSHCAAWALAVLGGAPRARSSSSNTTPKQRWPRRLYTTTMDQAARRRRNGTWLQQARPACCGGEQWQPGRRTALDGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P537</accession>
    <name>A0A9P4P537_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P537"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="338" mass="37086" checksum="E94324B991590B6A" modified="2023-09-13" version="1">MAQLTITAPATAPILKRKASVDLSPPEAKKQVYTDAEMKAALSKIAGGLTASRWATTPAEPSSSAFKLARPKGLQPQLAQLVPAPTPSNTQAPPTTAQLQLPPKAAAVNPPPMLNTPSQQVAIKHEPGTSPTPPTPLANQSKNRKKLRPRSRKNKASKQQPPQQAIKPPVLKISHKIANAPPVPIPAHLSPTQLRLYRFPHGQRVGCLFQQVSDAGDDYLINLAFTLLHNSLPADRKQDWVDTGIYEAFMYFRPDLDFGNVEAHQTIFERGACWEIKDAAGNGVVVDVAGKRINEVGMEVVRELVARWNTDHALRSKWPWAMRACKYYYPELCVGCWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5I0</accession>
    <name>A0A9P4P5I0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_185748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5I0"/>
    <dbReference type="OrthoDB" id="3751595at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="209" mass="23189" checksum="D48536F83098A521" modified="2023-09-13" version="1">MDTTITIAVVHVLATTVSTAITTYLNAPPKPSFRETSGETLYDEDNWARVLDIQDILSLVRPFLNVVKVLDLGPLLAKVQPVPGRNGQRLGTHADAYVSESNSEAPPPYQELPQNSVDYFCTQSYRMAISAERLVEVLKIAASGPTRSSPRAWNLHITASEETDLEVLAIYQSTRRTMLDAHPKSFLAIARNAMNLHDSDILTTVERHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5P0</accession>
    <name>A0A9P4P5P0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_525947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5P0"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF43">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="481" mass="54329" checksum="66AFEA9482EB4350" modified="2023-09-13" version="1">MSDSKSLDKIDTIVDERAVGHGPAKVPLRKRILAVVWDSLDKSPEERAFIAKIDFWILTYVCIAYFVKYLDQTNISNAYVSGMKEDLHLTGNDLNYLTTYWTIGYIIGQIPSQLILLKIRPSIWLPTLELIWGFLVMGMAGAKNVKTLYALRFFIGLLEASAYPGIMTLLGNWYTPQELGKRACIFQASSSAAQMFSGYLQAGLLRMDGKHGIAAWQWLFIFDGIIGVPIALYGYFAIPDQPTSSKAKWLPPAQKQMAIDRMEACRRRPVKRLTRRKVKEIFTSWPLYFFCAIFIAHVLGIRIYSYFNVWLKSTKKWSKSEINLIPTAGYGAQIFFTLAYAWTSDAIGMRWPVIIAACIPALIGCIILSVWPEHNIPAMMAGWILTFLETGAGALIITWINEICSESAEHRIVIIGVVEAIAFTFQAWVPLLIYDTGKAPHFPIGYQMAAMFFALEIVLTLCVWQIHKRYPVKGAKESDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6B2</accession>
    <name>A0A9P4P6B2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_425562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="MU001517">
        <property type="protein sequence ID" value="KAF2437291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6B2"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="270"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2437291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="460" mass="49734" checksum="B38454627EE45769" modified="2023-09-13" version="1">MAPSKKQPVYVLGVGMTKFIKPRGKVDYPELGFEAGVKAMLDAQINYDDVDQGVACYCYGDSTCGQRVFYQFGMTGIPVYNVNNNCSTGSTGLYMGRNMIAHGASDCVLVVGFEKMFPGSLQTFFQDRANPTSTTNLIMKETRGITKAPGAAQLFGNAGREHMEKYGSTLEDFAEIGRINHAHSKNNPYSQFQDEYTLDQIANSPMIHSPLTKLQCCPTSDGAAAAVLVSQSFLDARPHLRPQAIQIAGQCLATDTPQLFNRSAIELIGFSMSQLAAQTALAEAHTDPKDVRVCELHDCFSANEMVTIEALGLAPKGHAHDLIRAGAITYGPNTRVLINPSGGLISKGHPLGATGLAQCAELVWHMRGWANNRSVPDTRVALQHNLGLGGAVVVTVYKRADGSAATDVSSDEVGRVNRLGYNPAVVAKGFTREQVDRVRSRKARSEWALQDVGDKVEARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6D9</accession>
    <name>A0A9P4P6D9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_133637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6D9"/>
    <dbReference type="OrthoDB" id="3750626at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="489" mass="55650" checksum="07FEFE9359B05B5C" modified="2023-09-13" version="1">MAAFKDLPNELLDLIADNLPTGALCALSLTSRKFCAISVPYLYKTVRIPTPFEQAKDWENRVVFLTRTLTGRPDLAARITALDASIYHLNGTYDLRRFAPQSLTAVYGILNSTRVAPKHGYEMALRVYGGCNEPCFGVLMYILPNLESLFARFFTDISLSPANPEDLVDVFFNPDHGVGSAPSLSKVKKLDLQCTRVHMNPGIFPKHAPCWIDGSHTVMSINPNSNSSLRSPEITEIYSRESTNQLLTHNLWSRFSSRTFPALRRLDVDLDNIWRNMYTHEPVEVLCPGTTGWSHYLVSRLRDIKDTLEELRLTVRHGADTRFLEYIEPFTDPFTDPPIRLHNLKIFWLPQELLLPRDIEDRDFRDIDHQLLPAGLQSLRLLYPTMKTHSWLKGYLPNRVNLPSLQSIETMVTSKQGSVFLTHRQTDFKTWTTTTTRGTSDRVAEASAIPLGESETQSTKEAELLFEVALRDKHIEELEKLVAETAIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6J8</accession>
    <name>A0A9P4P6J8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_467403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6J8"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2438257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="335" mass="36527" checksum="7D5A865BEB755DD3" modified="2023-09-13" version="1">MSSRTLRVAVTQAEPEWLDLQGTVDKTIRLIEDAASNGAKLITFPEVWIPGYPGWIWARLVDPAMGARYIQNSMSATGPEMQAIQKAAQQHSIAVVLGFSERTSSNSLYISQTIISPGGEILLKRRKIKPTHMERTVYGDGSGSDLTNVVDVDFGGSVGSVKIGTLACWEHTQPLLKYNTYSQEEVVHVAMWPPLNSFGAQPAPENPALFSMSHDGAYALSTTHAIEGGTFVLYTTAVCTEKGIDTFDSKEGLIFREPGGGHAAVIGPDGRRLTKDLEGGPTKEGILYADLDLDKGLGVKGFMDVVGHYSRPDLLWLGVDRHEKKCVVERPREQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6N2</accession>
    <name>A0A9P4P6N2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_525263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6N2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000394">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="477" mass="52654" checksum="3E4F9FF48A7BDCB3" modified="2023-09-13" version="1">MTSPPHSIEHFDVDTKGMDVAKHERVEIAVGGVSWTPEEEKKLLRRIDLQLMPIMWLMYLLSYMDRTNIGNAKVAGMQEDLNLTSNQYSICLVVFFVTYVVFEVPSNMLIVRIRPSIYLPCIMTVWGALTCCMAAVKDYEHLVVLRIFVGVFEAGFAPAMLLLMSSWYKREEQSKRFGIYISAAILSGAFGGLLAGAITGGLDGAAGYEGWRWLFIIEGAATILVALLSYFILIDFPATTARFSDRERAIAVARLEQGGVTARAEGAERMSKVQAFTLAIKDWRTIGFILGYMVIVGSSTLSYFYPTLVHGLGYTSTVQAQYMTCPIYGVAFVCTAITAVYADRVPNHRGLIIACWLCFSLITSILVCVVYNFTARYALLVLMAAGLWASNAISLSYAGATFGDMEPEVRGIALALVNALGNLAQIYGAYLFPADDKPKYLLGFGVISAMLGIGVVVYTIMHIRTRRKDGMTNFFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4P7A4_9PLEO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="91"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2438163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="91" mass="9744" checksum="5B8A76393AD90854" modified="2023-09-13" version="1">MKLSLALATLAVFVSSAAANPVETTPQGACGPKWDWCDNLGEIRCECNGGHRLKCAQIWLDTGVTKFWNPVENCPKHGTKLQCIDGACVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="235"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="732" mass="82628" checksum="AFC6D73E7D04964B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8P2</accession>
    <name>A0A9P4P8P2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_490127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8P2"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="100" mass="10922" checksum="E2CAEDCB9DDDAA9A" modified="2023-09-13" version="1">MTDDVGVRFVYDCISEGSSVEKASSTLASNGISAVVRSRAGSAWKADVLPFEPIYGAVWEELGEEVQYQGMVVERSPAARDFAVAFYNWLGQAGKILSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9E8</accession>
    <name>A0A9P4P9E8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_446790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9E8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="162" mass="18069" checksum="5FDB536871104E9D" modified="2023-09-13" version="1">MTAPSCTSTSLFQTPLRPRDHLVKTADQPPIQPGIHIPSGRNVWRHLRVVPRRAMGPQDHNDGWRGPVRGGRCIEAPQLAGALLRRTCAYWTSHRGNPTVIHIYIAEYNPASIRRRLVGIVEVMLQIALVFAFWVNYRIVRGALCACSGSRGSSSRGRVPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9F5</accession>
    <name>A0A9P4P9F5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_523882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2440845.1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040436932" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19781" checksum="FC1D8B12AB021D2E" modified="2023-09-13" version="1">MLLYYCLFSLYALLVSADFDIYLITKDPDAPGFGVIGWQVVDPTRKACPDPARTRMFSRRTDVSGNKIGIRCVSETVLGGCEPLRGSYPNDIGLMEMHFSDTPKIHYTIYRSGHGKPWEMVGLQGEPGGYCEPAPWPPSDQAFSECGPFTLWKKMRCHSFLTADYINDYNRGWHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA44</accession>
    <name>A0A9P4PA44_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_421459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2440067.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="289"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="540" mass="61727" checksum="43998E2B6D3D6771" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA87</accession>
    <name>A0A9P4PA87_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_525368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA87"/>
    <dbReference type="OrthoDB" id="3790379at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="783" mass="83470" checksum="1FC6C717D828EDB6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAC8</accession>
    <name>A0A9P4PAC8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 1</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_435014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAC8"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="505"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2441354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="651" mass="72976" checksum="74FC5EB0CC054DB1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAK1</accession>
    <name>A0A9P4PAK1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_465250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAK1"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="787" mass="85484" checksum="6E5989D82A2079CB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB47</accession>
    <name>A0A9P4PB47_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_500175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB47"/>
    <dbReference type="OrthoDB" id="3798881at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1115" mass="120582" checksum="7F221ECA771C059B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBH6</accession>
    <name>A0A9P4PBH6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_447676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBH6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="196" mass="22204" checksum="FBDA08608FB9E836" modified="2023-09-13" version="1">MPPFSVSKNLSVVFFVEQRSSRRRPGRRTNKHNNAFHTLPVHVDSPKFRSVCVVIDSRACDRVDRQIPAWRDLAGPVVPVFRGGSEYSETRYGFMTKHSSIGSARACGGGAGFERSHRPVAVCRGRRFARNARMLKTDKEHNRFGGCLCEGRGSIVANLIAPRRKTSIRVRRHIATLSRAFESLARPDCSRRKRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDN7</accession>
    <name>A0A9P4PDN7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 11">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_90710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 11">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 11"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDN7"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="13">
        <location>
            <begin position="261"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2441149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="415" mass="45207" checksum="4C2E9F1A8E06256A" modified="2023-09-13" version="1">MATLGAHKKHKVTIVGSGNWGTTMAKLVAENVTANPTLFEETVSVWVYEEDVTLPKESRHFDPGSELATKPQKLSELFNKLHENVKYLPGITLPTNVVANPDLVDSCKDSTILVFVLPHQFIPRVCDQLAGKIVPFARAICCTKGVDVGEKGIRLMSEAIGMRLNIYCGALSGANIATEIAQEKYSETTVAYDPPPMDSRAPTPNGSPNASMVDLISPSKPVPSERSARLKALPIEYPPLAHENVRKLFHRPYFHVRIVDDVAGVSLGGALKNIIALAAGFVDGLGWGDNAKAAVMRVGILEMVKFGKEFFPDSCKTSTFTEESCGVADVITSCMGGRNFRCAKMSTQRGESIYEIEQKELNGQKLQGTSTAYEVNSFLKQQGLESEFPLFTAVYNILEGNAKPQDLPELIEPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDZ1</accession>
    <name>A0A9P4PDZ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_35014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDZ1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="150" mass="16642" checksum="DD04BA1F81DA0CD5" modified="2023-09-13" version="1">MAGCRRVAGLQLPTDTTCFAGQNRLKSPWQRGEWSAPPDKPRKLRSPCFGYGTIRLTGSRDAAMEDLGDTGSLRGFGSEVFVSRDLGYGRVLTHWGVSTLPDASLKLCFFRWNAHRLCASEEDSDPGGSHVVSRSRPLTKLSFYLVYRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PED3</accession>
    <name>A0A9P4PED3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_393320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PED3"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF67">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="37"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2441808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="565" mass="62553" checksum="642F74F5F9BAEA7D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFT6</accession>
    <name>A0A9P4PFT6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_432325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFT6"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2444265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="622" mass="68231" checksum="00F6BA4AEC6D47BE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFV0</accession>
    <name>A0A9P4PFV0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_62331</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFV0"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000114">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="367"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2442151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="806" mass="88461" checksum="23CF875CEAEFD698" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG72</accession>
    <name>A0A9P4PG72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_35800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG72"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="657" mass="73097" checksum="D2C30CB2C4E77499" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG95</accession>
    <name>A0A9P4PG95_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane fusion mating protein FIG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_33895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG95"/>
    <dbReference type="OrthoDB" id="3550957at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016509">
        <property type="entry name" value="Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007138">
        <property type="entry name" value="FIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="269" mass="28986" checksum="0E5580972F8652E9" modified="2023-09-13" version="1">MANMRFAVSMQRMIPFLGYHHVLMILIAIAVILLSLLLAGCSSTSPLIPGIFLVSMWYEKYTPTYSTEQVDPGVTAAIANIVGNAQLVVRVGYFGICINKDGGDYICSNNATALVQGVSVDQDPLNLVWVASTFKDAVVFPYLLIVAIILAFFCFVLLATFPGWHEERDRDTGSEVDIKPFPSRPVSQVALALIFIASIFVLVSVLWQHTASVAAATIAQDLGNGSVKAGVGTSAMVLGWFGFVLLIIVTIGLLVMILSIAVLDRLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGS0</accession>
    <name>A0A9P4PGS0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_433258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGS0"/>
    <dbReference type="OrthoDB" id="3687473at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="196" mass="21448" checksum="35D279D9F9EF7ADF" modified="2023-09-13" version="1">MEATAQEPYRDSPSSSRSSTPASSSRDQHAKPLPSLPLDTPPEPFDGLEPYRDEPSPGSPAPAPIVASPSPQRYRTPNARLRQAEIQVFYTPYTDAPRAPNDEDVPLAQLYPYPTEAPPPYQIAVRDSFRETLSHNTPSYSTSTIQDEEAAVEQVQSDDVRFTVEKAVAAIIVAMLLLVIASILALIAVSGFNWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH00</accession>
    <name>A0A9P4PH00_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_522794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH00"/>
    <dbReference type="OrthoDB" id="3798352at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="383" mass="41191" checksum="19DD1DC30D753475" modified="2023-09-13" version="1">MPTALRWRWSLDVRAGGGWLKAASEAEMGGAVGVRGATFSSYLLPPRIMSSYRPSNGKSAADKVETVDLTFSSSPEPEPRPKQPHPQRQHDRHPGQQRLPSYYKKEHRRTPIRTDGASSSSSRRHIAANISNPLPSVSADHLRQIINTSSPQKVAHLLLDLCKSSPALSGAVARGLAPHSTWAQNTIKDYQRRTGVPQVKAEVGKPSSSSAAIPGRSFGERSHDSPSTPHPKAPVKSVDILDPDSDDSLSDLEMIIAQPSRASKDKVVAGPSSSTHRAAPDQMPTSSSHVSQPALSVRVKPEPKTTAPLCMQCMKIIQPGSNCRFHLGGPKTFNQGTQKIQLWSCCKKPVSAAGCCDGVHIPLPESNHDPVPSSTGSKKPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH11</accession>
    <name>A0A9P4PH11_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_432071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH11"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF7">
        <property type="entry name" value="PROTEIN STB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2443986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="579" mass="65220" checksum="F7B91C794BF6A321" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHA7</accession>
    <name>A0A9P4PHA7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_390408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHA7"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="346" mass="39274" checksum="3E65E45CF91FE226" modified="2023-09-13" version="1">MGNEHTDYSGEIDVPVEAIQVIDPAVVSKLPEGIIVKAIAAHGASFWTRTARLDAEVDGEQKRYFLKTSFGGRGKSMMSGEFTAMSLIYAAKPDLAPKPIAWGTYTTIPDIHFFLCHFHDITDEMPDLHIFPAMLAELHRAGTSPTGQFGFSNTTYHGNIPIEHGWSDTWEEYFTRTTRELLRLEQEAQGHDQQLIQLTGPFLEKVVPRLLRPLETKGRRIKPCLIHGDLWYGNASMDGDSELPIIFDAASFYAHNEYDLGVWRATWNKIGKPYIKNYHKSFPVSPPEEDHDDRNALYATRVNVLDSILYKGNTGYREKLIVEMRKLVEKFPGGYEEYENTTISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHE0</accession>
    <name>A0A9P4PHE0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_289285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHE0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2445105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="502" mass="57644" checksum="3ED2CE0E02C12546" modified="2023-09-13" version="1">MGLGLVVAGVLLSYLIFSRLQLYLSRRNFIKQNGCEPCPKRYNKEPIIGWDVIKQNIVNKNERKMLEGNQKRFFDMGANTYLTKTLNVPMIATCEPENVKTILSLRFKEYSFGNRYHAFAPLLGDGIFNSDGEKWQNSRHLLRPNFARDQIADLEAFDRHFKLMLKHIPRDGSTVDLQNLFFKLTIDSATEFLFNHSTNSLRMSEDDTDNEDAIFARAFQFAQHDIITRFQWNVLNFLRPNKEGKDALKICHTYVDKFVEQAIREHQADKAAGMPGDDRYIFIKELVKQTNDKERIRIELMNILLAGRDTTASLLSNMFFQLALRPDIWAKLREEVAPLEGRLPTYEELRNMKYLKWCLNESLRIHPVVPGNSRFAIKDTVLPLGGGPKGKAPLFVPKGTVVAYSPYSMHRRTDFYGPDAAEYKPERWEKLRPGWEYLPFNGGPRICLGQQYALTEASFVTVRLLQEFSKIESRDPNGGQWEEGLTLTVCSANGVKVGLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHK5</accession>
    <name>A0A9P4PHK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_416524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHK5"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.10">
        <property type="entry name" value="alpha-amino acid ester hydrolase ( Helical cap domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="286"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="667" mass="75273" checksum="D22C049AE92C4FFE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHW7</accession>
    <name>A0A9P4PHW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_414533</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHW7"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000083">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040189190" description="Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="401"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="463"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2444466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="522" mass="57601" checksum="14792A73548C5580" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI01</accession>
    <name>A0A9P4PI01_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_432357</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:manganese ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
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        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="7"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2444297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="532" mass="58393" checksum="1557E5B4CBEB636C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIA5</accession>
    <name>A0A9P4PIA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_485958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIA5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="120" mass="13797" checksum="F36D422FDA6C60E0" modified="2023-09-13" version="1">MSKPKALPRVNVSEVKPLSQPLQVIVLGEPESDFKNNDNVDPDNWYKHTTYYIVKKSAYLKRKMDEGPEFYIDLYREALGKITSKTVASYFHIIAHGTRIRRLLGWVTQGASSVEERRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIA6</accession>
    <name>A0A9P4PIA6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Betaine lipid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="93309" checksum="4060F12AB9894B51" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIG2</accession>
    <name>A0A9P4PIG2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-ornithine N(5)-monooxygenase</fullName>
            <ecNumber evidence="5">1.14.13.196</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">L-ornithine N(5)-oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_431564</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="5"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIG2"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000195">
        <property type="entry name" value="L-ornithine N(5)-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2444766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="528" mass="59105" checksum="11B858C30A3C4E0F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PII3</accession>
    <name>A0A9P4PII3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PII3"/>
    <dbReference type="OrthoDB" id="3765308at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="438" mass="48175" checksum="9AFF3131C14CBFAE" modified="2023-09-13" version="1">MVIRLFPGLSAPAEQLEWLPPNRNWALAEPIDFAGTYGLVGAVVSGLALRLFRRARPGAFAFRLGASSMLVGGFYAVPIVDYRVTREILLEKGEKLSASPIKLWECKKELTADDGAVLGGIGLLALSIKFKRRTVGMLPTWQRYVGYAGVTTAGAAIGGSIAANLCFSRFKSSCSLKAQKDLCKAEQNRIDDMKRLAESPVFLEKLGRVFMGIPHFWAMLSQDLEERRMGTSEASLATPFPNMSPVSWLPQPIYPVLVYVGNDEPRIDWTLAARSNPQSSGNTVDTMTREAEYVAFQINERIQTLNLAPPGLISPQNPLLSSVMTLIRLERCILEDIEEEKSHHGESFDVSAFLSSLNIEAKHNRDYDPQASVSCLRRSLGNLDKGFESAVAKGSNSAELSNHRTGLKGLINDLERQSYAVQNLQYGGIEGPREAQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIZ3</accession>
    <name>A0A9P4PIZ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_359410</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIZ3"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="171"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="366"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="628"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="711"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2444872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="763" mass="85550" checksum="8E13EF07759B1F4F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJE3</accession>
    <name>A0A9P4PJE3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_361452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJE3"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2443951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="138" mass="15485" checksum="86EC64A18244EE8F" modified="2023-09-13" version="1">MSDVQKKLQALSDDYQTLQGELSSAVEARQKLESQQQENTTVKKVSKKASRGIGVLIMFQEFDILDDDANIYKQIGPVLLKQDKTEAVMSVSARLDFINKEIERIEKQIKGIQDKSEKVKMDIIQIQSAAQQAQEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMI6</accession>
    <name>A0A9P4PMI6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_441762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMI6"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="625" mass="76176" checksum="5C10592C0B5130DA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMR7</accession>
    <name>A0A9P4PMR7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_355799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMR7"/>
    <dbReference type="OrthoDB" id="4150019at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="462" mass="49980" checksum="033B96962A3CD3B9" modified="2023-09-13" version="1">MAVGVERRAKIVAAKLDHALLLQPVSNAMSYNPLAQPPGPAFPVSEATSPEIVDERSDYYSAQTDQAAETSPQQLLLKKRRASKDKAAVIRRSSSTPHMRNLALGTASELSPTGDKRRNKLGYHRTSVACGHCRRRKIRCLVANDEVTGRCANCIRLKKECNFYPVDQTPEQSRAQAGAAKEASAVAPASSTTSSPRHAVSVVGAKVDEFRPPFPGTLSTNSTSRYEVPSEPDSDPHHITTTSGMPVQQQPGYGYPQPIDTQWPPSTGFLPSSSVSESPSSSNGYWRPSPTTASTVFGSESNVSGVHTPVTSSTMSYGNHQDHHNWAPQNFQPPSRSMSYGNIEGLPQHFQSQPLVVPSHEYRRTAPYPFPTTIDTSSTAIQSTTIGPHSSAPLSAPIISGNPYTYPPPWNPYQSGQNPGPEGPVQSRPIGGHWYTEPGHLGQVQEEGAPPMTYSHHGMSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNB8</accession>
    <name>A0A9P4PNB8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_358098</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNB8"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="178"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2445961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="783" mass="86123" checksum="6DB6A88F412B8962" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP99</accession>
    <name>A0A9P4PP99_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_409113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP99"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="207" mass="22481" checksum="461FE9B14102E5AD" modified="2023-09-13" version="1">MADSTCGVCNSAPKKYKCPTCALPYCSIPCFKEHKRTHPEGASAAPAPPAVVEVEIPTATPESIPTYIRTKTDFSRLATDTQFQTLLKSYPTMLPTLQRIYAATIKPDLEDAPQRRGMRGRGAFRGRGGRGRGRGRGRGRGGWGGGDEMPRWTSKQGDNDALRILKSLREGSTAEETSGIGEFVRLVEGMYGDAKHTEGEGDAMNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQD7</accession>
    <name>A0A9P4PQD7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisomal membrane protein Pex17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_481325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQD7"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26001">
        <property type="entry name" value="Pex8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="77061" checksum="F76DD262B405CE9E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQE6</accession>
    <name>A0A9P4PQE6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_440670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQE6"/>
    <dbReference type="OrthoDB" id="10351364at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040455760" evidence="1">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="224" mass="25667" checksum="8662A430DF516AB9" modified="2023-09-13" version="1">MAATFAYLMTILVALIQFMLVSADFDLYRVAGSTPWKGHRVRSSDITGPLPPFVPIDLGWQLFDWDAEPTCERLLHAPLYPTSKDLSHGRLGVRCVGKCSIYDRPWGHVKLVEFHFTNFPIYHATIYNDDGYERDGGWKWWMWGVDNLNYGECFTYDNFDLDCEYPDIKTYIRVSRKFRCSPREHSITAKYINEAYMSEGGENILHEHHGKRAVGNATAVAGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQR9</accession>
    <name>A0A9P4PQR9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_353215</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQR9"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="56"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="237"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2448457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="399" mass="45514" checksum="DCA5CD5F590F7C8C" modified="2023-09-13" version="1">MAETIDRNMDDKMEFSTSKEVSVAPTFEAMHLKENLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFSISILQVIDTAVRETQALVLSPTRELATQIQSVIMGLGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVSGTPGRVADMIRRRNLRTRNIKMLVLDEADELLNRGFREQIYDVYRYLPPATQVVVVSATLPYDVLEMTTKFMTEPVRILVKRDELTLEGLKQYFIAIEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGDMPQRERDSIMQDFRQANSRVLISTDVWARGIDVQQVSLVINYDLPSNRENYIHRIGRSGRFGRKGVAINFVTQEDVRILRDIELYYSTQIDEMPMNVADLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQY5</accession>
    <name>A0A9P4PQY5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_427861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="614"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1375" mass="155052" checksum="E0928AD9C9331FF2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR10</accession>
    <name>A0A9P4PR10_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_440179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR10"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="344" mass="39860" checksum="03DC640DEE64C45C" modified="2023-09-13" version="1">MDPLFYEKLPKIRYGLESGRCKDNIGRRGLSRKEPLQLLNPFLLKMGKVIWIRSEFPVHLVPLETRSIDFASTIGCPTAICIQPRETYWLVPQCPLREGFKEGWEKLAQELRDMILACNLAVGGVDQSNDYATAQNNYDLAFQRYAILRERYRIGPPKFIWPKNHLLLKQHRALYHSAAASQAADKVFYEVNEIRLHPRPPDRFPFSYHLRLPNASTRHWIRRLVYSFYTTPEAYASLQPLARKENGFTGLAFVSVKIHRWRPNIDYAGSTALMRMSENEANRMLEEKLPGNAKFECDGVLTFPMWGVFYDNSNSLAEVVLQDIMRRKITFNNKVDAVTETGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRH1</accession>
    <name>A0A9P4PRH1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_429509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRH1"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2447918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="481" mass="54145" checksum="25873AEAAD97B8BE" modified="2023-09-13" version="1">MVTKMVKSIANHDLPKPPSGKYPAKAHCRRVAAWIAENGGPSSGVIYLQGQTLKEHEDDDTEMHFRQRRHFYYLTGCEVPDCNFAYDIASDKSTLWIPPVDPSVVMWAGMPLLAKEALERYDIDAVLTTDELKSGKSVQDLLKKPNETLLVIKDRADLDVFHTDNVKHLEPNIDYEWARRGIEQCRVVKDEHEIAMIRHANIISSYAHEQVQASVHAASNERELNALFTMHCHANGCKEMAYGCICAAGTNASTLHYVHNNLPLTNKLNMLMDCGAEYNCYCADITRTFPLNGRFSPESREIYALVLKMQTECMGMIKAGVQWEDVHMRGHTVAAAGLRDLGILKKELSVEQILDSKITTRFFPHGLGHYLGMDTHDTGGNANYEDPNPFLTYLRVRGKLPVNSVVTNEPGIYFREFPLRQELKDGVWTDVVDERVLDRYWSVGGVRIEDDVVVKEDGCENLTTVSSKLEDIEALCGTIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSV2</accession>
    <name>A0A9P4PSV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_349784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSV2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="53" mass="5867" checksum="3F03ED8E8C446161" modified="2023-09-13" version="1" fragment="single">KEIIVSCGAQRTLQPLMLSGIGPRNEPQSLSVKSRSTLLLWKKEKEMSSTTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSX5</accession>
    <name>A0A9P4PSX5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_405005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSX5"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="879" mass="98844" checksum="6738E6700B3227F2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTK2</accession>
    <name>A0A9P4PTK2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTK2"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014500">
        <property type="entry name" value="UCP019307_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019307">
        <property type="entry name" value="UCP019307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="70"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="194" mass="21410" checksum="57991FBD745A355A" modified="2023-09-13" version="1">MPSLDLTPLASLRLSTHLITSHSNIPNTAPHSHPLFIYHSVYPPSTSASTLESHLPSNGLIPQWRYTMYSTTHYHSTTHEVLCVYQGRAKLLFGGEQNPGKVEAEVKAGDAVVVPAGMGHRLLEDYGDGGGFMMVGSYPEGCNWDMCYGKAGEEENVKAVRKVPWLKKDPLYGDNGPVLWSKEKLEENRGKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTY1</accession>
    <name>A0A9P4PTY1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_516269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTY1"/>
    <dbReference type="OrthoDB" id="10587850at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="469"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2450376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="535" mass="59651" checksum="98652013F4D369E5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUE5</accession>
    <name>A0A9P4PUE5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_222497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUE5"/>
    <dbReference type="OrthoDB" id="3763672at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="44642" checksum="002C537796EDB740" modified="2023-09-13" version="1">MAVTHCNFPRLVIAVICTFIILGLILHSKPEVVPSLEQLQAIAQEYRPTWNYTSTSNTPVPVEEASTRERIQALFGPIRHSLTDDYIDASGKTFGLKQLPRWREPLKGKVLIVDIDTREPNGNNEMLNPNPMNWDRLEMSGGQLVSGAIMGHYLYSQIHDYDYTFFQAHRMEGYHDTWILPGAMRQMIETESYQWIITMDADVTITHPELPLEWLLNHWGATNNTSIMMPIDQKVFDNDIINSVDSKGVTVLNTGVVIVQNLPYTKEILDAWIECPNDKRYPGCSQWKDKWSHEQRVFSEYIRYDFNPKGDNIVSIPCDDAMGYPNMKNEHQGMILNDCNGNFFRHHTLNKGKAKQSLDVSIMQLLTQLMHESFVENKDYLWFKEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUS0</accession>
    <name>A0A9P4PUS0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Het-C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_378170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUS0"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF11">
        <property type="entry name" value="TINC (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040188185" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110883" checksum="DFB56F47D60A6B51" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVA8</accession>
    <name>A0A9P4PVA8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_503959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVA8"/>
    <dbReference type="OrthoDB" id="4672515at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040473528" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="259" mass="27194" checksum="6C206D792AEB8C0E" modified="2023-09-13" version="1">MLNWELAALTVIAARSSYAAPAVIGVGVGSSCTNVSFTNSWLIADCLTKADSSTHIQSSVYLNNKITNDDGTLKKVDGSFLGSCNTYSLGGAKLTCSCQRSAGYTLTSALNLKEHIANYAGRLLSDLSGPPAVPPTSSAALFPSDPSWPLRFGDIACYSPDSDFCSRYPFSNPGTCGVGPGTKPESCYAVREPLSGHVYRAFAQLQVGAPSKAWRVEAYGDLACTEKVGSVEGEEQGTCKKLGGRAVAVKTVPLWNADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVT9</accession>
    <name>A0A9P4PVT9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Including n-acetylases of ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_198605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVT9"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="211" mass="23334" checksum="6F2A308DA29CE32D" modified="2023-09-13" version="1">MTDPNFHITTPRLYLSYFQPSNPTHCDFLVTLYNTPYFIASSGGKPTSITTRSAAEERLSGRFREEHARNGYGTYLVSLRPTSTWNEPEDETTPFPERLSACKHIGTVSLMRGVPPNAYSAPDLGFAILPEEMRKGYAREASEGLLAWADREKGVRDVLGLHDPSNEGSKGVFRSLGFEDRGIHALKVFGGVQGAVWVKKGMDSDLSVYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW73</accession>
    <name>A0A9P4PW73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_4261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW73"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="730"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="853"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118582" checksum="DCFCEB4C9C5CB863" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWW7</accession>
    <name>A0A9P4PWW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_426726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWW7"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004104">
        <property type="term" value="F:cholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="24"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="4">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="533" mass="58008" checksum="37991AA30404646D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXH3</accession>
    <name>A0A9P4PXH3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_439630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXH3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="227" mass="23967" checksum="FA9966F7D5C40979" modified="2023-09-13" version="1">MSGLRLAGPLRAAACSGAGAGLTRTDEARRGRGVGVVGVHLLAASTASSRLRRRKPLPPSPAARPIGASQGINGCLQLQSSPTTRAERSTVPDVAAHPLAPQRAPSPMACERRCPPTGLGEPAKAARPPSSHLADLADLSMGSMIAIWRLVRSPASAPFDRPRPCRTPNSDERSGDAVPNVRRAGTCLELLPLPLLRLGHLKPVARTDDCLRFQEVAAIWLRNLCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXH5</accession>
    <name>A0A9P4PXH5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_347804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXH5"/>
    <dbReference type="OrthoDB" id="5333655at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2452052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="508" mass="58827" checksum="84F6B0BC3F31DAF4" modified="2023-09-13" version="1">MPRNLARLRFRAPKQLRPLNIARIHPEDHTTLHRRLRAHALDLSKPQTPLSLQVVVNPKWKQQPGKKPFRMSYKPHTVRDLVDPEAAAKHGQIIYVFANIKTGQVIYSLNELLDQYHLDQLPFLGKHSKPPTVRPDEWTPHCVITFPVAEQGLQAFRKLREFRHLHETSWDKTNPEWVRLTPHQRMRKIMDQVANTSADLAAVLSVQQQQSVEMRKKTIEHEKKSFRLMKTMWAEAEALAKDDRDASNPKWLEQQIRNLEWQLGTKRNRDEADTKRLQDAKKGHEVRLRRVLRARKNMARLKEVEETSEFKKMQEGYASQAAPATGVDVEAKLETLRKELALERDLTKVLDRSQEDAEQTMGAKQAEITQLEDAFIASLRAEARDHPVTRSILPTELKKQPPQPFTMDVEIKWADLRNAEYAAGNWPDPVVHDTLALRSSREDVQLLNPEQYNVTVSDDVQAMLKNLERQALEAQGLYEEPVAEPEPEKTGVWKYIPEVKNPFKRAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZQ4</accession>
    <name>A0A9P4PZQ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_20419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZQ4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2452163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="202" mass="21515" checksum="E47F6728BEF74AD4" modified="2023-09-13" version="1">MMILPTARPAIPPSVSPAPPAPAPQSCLHHFFLAACAAHSHQTFHALPRTQRARTTALRAASRRRRAWVGVEQVDGLRMCGVCVGRVCESFVLGGARVGLPRHDATRSMVPYCRHTHAWAGVGNPLGWAGAGGGVTAGLGWEEGNVVDERGCVCVCPCPCRAVVPGWRGDAGLCTSQPAGTYGRLARQGSTRKTIEWSFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4S5</accession>
    <name>A0A9P4U4S5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_449468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4S5"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF14">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="18"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="509" mass="56644" checksum="FF7BC619FF99A9FE" modified="2023-09-13" version="1">MDYPILLIERLKSIYEDAGAAIAILHHGRLLHFENIGFRDLKSGLPVNDETIFPCASLTKAVVPAVVASYVEEGSFTWDTPVKDILQNFHTRDATLHQHMTPVDCLSHRAGMQSSLYWLGSDNNVLISNQNSMNFINDLQRVVPFRNGYLYNNLGYELAVHVLTKMTRTGTRAYFDGGDNVAKTYGTLDDASNVAITPMLSGDNTVGGPGSAMRSCIKDLIKLYASFLAAGKHQLATGETKTPGSPIQQVASLWSSKISMDPISFHETTYALGWARVQTPGPMGAIGLNPDLLSPKPAPYVAREQPSHLVIYHQGSMPGNLAAVNLLPATGGAIIVLTNSLALNDAADWLGQLYSEAYLGVRKRHDYVALAKETVQSALEWHPRLIDELKAGQIRDTQARKASENAGILVNEARTMMIKVFVDDQDSILKLSFQGMDNEIFPLTHYHHDTFTWLVTRNKFARRGRFTNDNAEYFKVNFLPDPKSNKIEHLTWWHNKWLPKAEMFSKEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U522</accession>
    <name>A0A9P4U522_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_477960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U522"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="167" mass="19177" checksum="86FA7E65047E911E" modified="2023-09-13" version="1">MTIAIYMKHVVDRLRFDAVGLASLLSTLIVGYLPYDASRRRRLATSRRDCGGFRNHRESPMNRSLHHGLSLLMVETTVSLGPPPMLLQRPAFWLRRTSMAPAAWPTLHQRSDNNQRQMIEDRVASDICLWFRFLGPNMELVLEDTPIPALTRRERGCAVHEKEVDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U544</accession>
    <name>A0A9P4U544_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_423992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U544"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12658" checksum="CDA41351653221DA" modified="2023-09-13" version="1">MVYTIVVHLYAKEDQESIEKLKAKLVEASQVYSKDKETLSWFVMQDVADKRKFTIVERYLKESSQKYHLENPYWKTFDPYVIPLLEKPMDLRRLEELDTSESAAGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5M9</accession>
    <name>A0A9P4U5M9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_490654</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5M9"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2439219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="261" mass="29438" checksum="2D37A6D715958D3A" modified="2023-09-13" version="1">MTRFLAFNADGDGENQHRIPEPPSKITRHALRKQEWETEAAANRPASRVTKSKKKKVKRKTVTKVLDAIKYESDELQCLACLLYGDDPACTSKCYTDFTRQSFRPITNSVQIRGPGDLGYSAHTTVPIEKHEWIGEYIGELRPLSLSDTQQSHYWLPIPGQCAIDAERKGNWTRFMNSSCKPNVKVWGETLGKRHVVLFQVLKNIAVGEELTFQYGKAYFEKAGFECRCDAHDGEPHMPGDKPAAKKPAKTTGKKVLKNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U606</accession>
    <name>A0A9P4U606_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_491958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U606"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="93" mass="10517" checksum="DD0988FE0DB24831" modified="2023-09-13" version="1">MAYLGLAKSCALVIASVAYGKLGKLAFVAYELTTLDRFMQQLQNRSLLEVIDKNMDYGRNVTYNEADTRPFFPGQQHQQGQFALFCEGSWTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U628</accession>
    <name>A0A9P4U628_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_466938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U628"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040533406" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="19"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="525" mass="55795" checksum="A008947A3B1C711C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6D7</accession>
    <name>A0A9P4U6D7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_116941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6D7"/>
    <dbReference type="OrthoDB" id="3799527at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="254" mass="28214" checksum="99416848A716403F" modified="2023-09-13" version="1">MFVPLDAPQTHTGTSHLPFLTYLRLKLPCAYDFAHLASCMPGTVALRLRHLCLQIVDGTGPGGDLSYTRSWQGDGNPFDSDEGHLFSNLQRKHPNTAYMQDICGLVNRCKNLESLGLVGTQCINLESLNWQPAEGPGLKTLYMSRVIATAEQLLTLLSSGRGDGACHIEAFDIKDVELMNGTWESVFARLLTSSSLVFLQIFNLKYNIRGHSAHLALYNSRPWENVSEIWTKSRQDCERLSDVISAVESRVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6N3</accession>
    <name>A0A9P4U6N3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glyoxalase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_372176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6N3"/>
    <dbReference type="OrthoDB" id="4179687at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32197" checksum="D03330D02762FE98" modified="2023-09-13" version="1">MPGPGESSKSKVPGKLGPAPTRLRQIALAVKDLEQARRELTHVIGTQVIFEDPAVAQFGLKNFLVPLGGDLVEVVSPIQNNTTAGRLLDKRGDGGYMIIMQTEDAKERREYIEANHLSKVIWGYEHDDVVCAQYHPKGLQGGMMAELDSHAPTKNNPTPLKDRFSPWHACGPNYAKYSEGMKRTSHLTLEGCVLRLAPGDLGHEAAARRWEEVFGVGRSRDLLAFTNARLGFVRGQDGQRDGLVSVTVGVNGTREFQEILNRASKAGLCGDGFINMCGIRWYFVLTGRDLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U794</accession>
    <name>A0A9P4U794_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_422165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="752"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1139"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2439566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1303" mass="145219" checksum="FF1C4E1F0698EC4A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7D8</accession>
    <name>A0A9P4U7D8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_397170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7D8"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="8"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="354" mass="37394" checksum="FFAA7C7ED30457BB" modified="2023-09-13" version="1">MRAARYYGKEDIRVEEVEIDPCGDGQVRVAPSYVGICGTDLHEFLGGPTFAPVTPHPLSHDTVPITLGHEFSGVVSEVGPGVSQFNPGQHVVVQPTLSCGRCSACSCGAENVCEKGGFIGLSGGGGGLSDSVVVPQGSVLNLPEQIPLKVGALVEPLSVAWHAVSAAALIPGSTVLVLGGGPIGLAVVQCLVALKTKKIIMSELSKTRQRFAREFGAHHVLDPKTYDLVAISRELSGQGGPDVVFDCAGVPASLVTAFQAVKPRGTVVNVAIWEREVPFQPNMLVFKEAHYTAVLGYQREDFQAVIDHLAEGTLKPERMITSTIPLNDLVEGGIKALIKDKESHVKILVKVDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7M4</accession>
    <name>A0A9P4U7M4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_434101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7M4"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="58"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="559" mass="62348" checksum="8CD3C1F1A6D0EB90" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7N0</accession>
    <name>A0A9P4U7N0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_436522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7N0"/>
    <dbReference type="OrthoDB" id="3943694at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2439192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="498" mass="54365" checksum="864AB5AE3F963C52" modified="2023-09-13" version="1">MSAQNESSDYRLTDADLEEYPIERHHFDPVVRAAANPDSRVLAAILALKDPYLNPSTFDGRQSALTSAIEAGLLENVKILVNAGCDPNGVPYDSMLKDAAYFWGLLPHWSPLGSHRQQQSEDEEDGVYRSPLDDEDIRSRQKTRLPFWSAPVKGYPVRGQKPLLTALDAAVVSENIDLIEAVLDAGADTKAWTERHDAMPENPSVSFISPSTPLHRAIETGNTSVARLLLSKGFRVDVFPLAAVTRCLNPLMFSLATRSPDLSWYALLSASPTAAHDQLSPIFKVHIAHIACATLSIAALEAVANHVPLSDVRPTALGHTLLHIACLPSNDDAINHFSPKIHQSIHDVRTLAAFTPHALWPFKPPGQFRDVTPQFSAAPSELEPQLAMIAFLTSHGMADWTARDVHGNTPLHYLAAHRAATAQTLAAGLAEERLGSAWAERNSWGYTPAELVGDGEDALRGLAGEGRTPESVSYMPHWRDAMGSWIAGKWTSSYPEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8Y9</accession>
    <name>A0A9P4U8Y9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tcp11-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_365566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8Y9"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="69312" checksum="4D88C1D5C8CDF80E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9N7</accession>
    <name>A0A9P4U9N7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_456287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9N7"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF11">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2442340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="278" mass="30290" checksum="A55C13964978BB1B" modified="2023-09-13" version="1">MPRCNLAMQVSSDVGCRVSYSKSPPTLRFTCMEYQGAQFGDINEPPLQHENLIFQKTNVASWSEPSALFKAAKSTYGRIDHVFANAGISGRTTSLEETPDSNGDLVEPDDRVYQLNLKGCANTCALAIHYMRRQETGGSIVVTASASSFQRFRLVDYTMAKHGVLGLIRGLQPLLHPQLPIRVNGISPRWTATGLAPKEFIETVIPTQTPAVVARSVALLMADETRHGQLIYSIQGRFSEIEEAVLLPAAERIVGDMSEDLVLTKLQAAAADLGLSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9Y1</accession>
    <name>A0A9P4U9Y1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_73473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9Y1"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="115"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2441547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="576" mass="62217" checksum="E842C867D815F285" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9Y5</accession>
    <name>A0A9P4U9Y5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_456405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9Y5"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="237" mass="26308" checksum="C8CFC339ABEB99F5" modified="2023-09-13" version="1">MLCTIVGATGLVKKSWGTTSDVILGRFRITSQDTTFVAWLVNTPQLILSFCYLSINSQCTIMAGAHEWNQLAKSRKGLRVTKPKQDQRSTYFLQLPYRWSLPIAVMSGGFHWLLSQSIFLVRLDYYVRDGKLLEGEDGSRMGCGISGLSVVVLCVSFWILVMAVGSMGQKLFTVRIPFAASCSLVLSAACHPPLADPKPYLHKVQWGVVGERIFDGEKHCSLSSMPVKRPKPGTKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAE7</accession>
    <name>A0A9P4UAE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_445662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAE7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="228" mass="25436" checksum="5B9C83404E1630E6" modified="2023-09-13" version="1">MSHTTPYPTGELTPQLHSPLEEMITQRERSRRWWICYITPDPSATNWSLPGYASRLGSSDSMWTHSYSGSTVSVMPSQLSSEDPSSSYRASKFPNNKYFWISPVAPYRTQSYFESSAPSTMSFATSQTQSSPIPGKPRLASRKRSISSIDIEPSPSVDSTEAAKPAKKPKTSSCELLDIKKGRKTEHQRSNHPSIERTAQITLPDTNPTVQPTESCHALSDVRKQNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAQ9</accession>
    <name>A0A9P4UAQ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_432600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAQ9"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="837"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="873"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="913"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2443316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="998" mass="109875" checksum="7A88F216F1188681" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB93</accession>
    <name>A0A9P4UB93_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_433262</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB93"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="68"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="545"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="690"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="507"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="653"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="724"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2442882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="742" mass="82678" checksum="5F01F3D4801ABCB0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBT9</accession>
    <name>A0A9P4UBT9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MYND finger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_494833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBT9"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4470" evidence="5">
        <location>
            <begin position="100"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2444501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="578" mass="65977" checksum="843CFB54C9EB19EB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBY2</accession>
    <name>A0A9P4UBY2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_454474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBY2"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="294"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2444636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="373" mass="41958" checksum="49799A1A0D86540D" modified="2023-09-13" version="1">MPTELEELVEFLHHGNTQIRQVAAENLLGYSQADLPLFKRNQLEPVKDLKLLVKDYAPIAKNALTILINISHDGEVLRSLNDDAFLEALLSRITNKKEPNANEIAMLLANMAKDDSLQRVLKLKRDVPKHLSTSAWAMDQLMDCFVKGAEGGYNKDADYDYLAYFFADLSKFPEGREYMTTPQAHDSDIIPLTKLQVFTSHASHIRRLGVASTMKNCAFHVPAHPILVSNLNPDPTLPPPHIGANMLPYVLLPLMGPEEYPDDDTEGMLEELQLLEPDKEREGDLEIMKTHLETLLLLCTTVEGRKVLRQVKVYPIVRECHLQVEDDGVREACDRVVQIIMRNEEGEEEEIPQGAVSAAGADEDEDDQIVEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBY9</accession>
    <name>A0A9P4UBY9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin, gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_432828</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBY9"/>
    <dbReference type="SMR" id="A0A9P4UBY9"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2443602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="375" mass="41639" checksum="0520E7883A359B80" modified="2023-09-13" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFALPHAISRVDMAGRDLTDYLMKILAERGYTFSTTAEREIVRDIKEKLCYVALDFEQEIQTASQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGISDRMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCF1</accession>
    <name>A0A9P4UCF1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_521202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCF1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="154" mass="14897" checksum="C6B05D0A3284D6E3" modified="2023-09-13" version="1">MLICFSRPNQHGAPPTTNPHRRGPRRGLRTFFFDFDQGVWSCCVVCVPLRVGQEDEGGGGGVCGELGLLVPGAGGEEEEEGEEEGGGEGGGGGGEAGSADQADQKGGGGGGGGGGGEDEVGGGGMEGEGGGGEEEGCGGGEGRREASASEGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCH1</accession>
    <name>A0A9P4UCH1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_414328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCH1"/>
    <dbReference type="OrthoDB" id="5210591at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF59">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="376" mass="42031" checksum="550B3A235C0222FD" modified="2023-09-13" version="1">MQILSLQIPIEMHLPPLDAAVYPVVPTNNGRHISRAARASSTVSSISSSSSLSSPTCAPSADFSGIQRAIQSVFRSSKITVQKAERIPGRLHQVYRAQLTDGSIFVLKCPPHTSSRALRHEKHGLETELRTLRYLREYCQGQLPVPEVYQYQEHGGVLGSPFLLMSFVQGRKLSEMLPYLSTHERNTIDRTLGSYMRTITALNAQQFGMTHNVFANKGSTSWRKAFRALLESTLRDCEDMLVTLPYDSIRYYVEQHVHTLDEVQTPCIVAMDMCDAQSVLVDEQTKQVTGLVGFSNVIWGDPLMNEAIANGSDAFFEGYGERPPRSAGPHTRQLMYAIYRATVQIASLHYRPQPHVSDTDARRSLTYAVNSLAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEB6</accession>
    <name>A0A9P4UEB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ALDH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_512097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEB6"/>
    <dbReference type="OrthoDB" id="5596991at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43111">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43111:SF1">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="195"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="488" mass="52834" checksum="5F1E83EF16188D1F" modified="2023-09-13" version="1">MTATTLANLNAVALTGRSSNPFFRREQLKFLHDALRGEVKSIRDALRQDQHVTDAEATIEIATALRHLKAHYEGIDQKAELESEYKPTKAKDVADRTGPWGVVYIEPNLGHTPFFSVVGPLAAAIAAGSCIALKLDNTPRALPSLLRSLLLKALQPDTFQIISTSPQEGPTPNLLSVLQEAGAEKPDYTQLVSSSGRVLAVVDRTADLSSAAEALVAARFSFGGTSPYAPDLVFVNEFVQREFVEQVLKHGIRYLAVTSSNGTPNVTLQPKERNASDVLATLSENKHWQTTIITLGSTGAIVELTNKDTTHVPLPPRLDAPVFAVSAVSSLDHAIDLITNDSDDRLSAAYHFAAPAHAKYLSQFIHAEVTFVNHIPSVLLLGPGAPLFHNVDVENRYRKEQFQRASPVLVRPARTQASTISAGKDAAKLLEDAAKEIKEPKRAESIAIGYFEQGILIGLGVYGVPLLTCLGASLFFGVRAGLRRFEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFF6</accession>
    <name>A0A9P4UFF6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_407623</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFF6"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000260">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="22"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="12">
        <location>
            <begin position="680"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="13">
        <location>
            <begin position="820"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2447458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="952" mass="106178" checksum="FF2FCBCC271CE29F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFL8</accession>
    <name>A0A9P4UFL8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_426615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFL8"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268:SF6">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="170"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="415" mass="44971" checksum="4AE9D086474A111D" modified="2023-09-13" version="1">MNNVTAQKDNSDPVTYTCTCPAQTEGGSVLLFYRYWANAPVLPPEHSQKTHDPQDLANFHAEIAKSLHIGAKFRIATEGFNITLGGTSPTIARYIDACRTHWSFAGIDLSTQLTRDAYFKPTPGCACAFGGKASVNVTAEITPLGITNYAPATWNNVISLPPSEFHDLCRKGDIPLIDVRNHYESRIGYFVTGDGGVAVRPAVRRFSQWPGYVVRHVLGNDVYRKPAGVATYCTGGIRCEKGARWMQEALAGEGGESGAPVYTLHGGIVGYQAWMEEEVRAGRKRPEESFFKGTNYVFDARGAIGNQQAVSTCHGCGEAEDRLGKCEVPGCHLVLVVCEACETKGGISCCENCRDVREGQGIAGRSTHICKCESEREKSLWGEEGAKLGRGANGRRQRAQQHGDTVFSPGAVSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFT0</accession>
    <name>A0A9P4UFT0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_481444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFT0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="187" mass="21885" checksum="9AF4BA9BDAD4B326" modified="2023-09-13" version="1">MVAQSSDTEPQPLDWDDERKRLRVGWFQDGREAWYNIVPSMVTAEEGSSIQKGAKTRSCFFPGVVENVPVKELDLDKVPEQLTVTEFPKEKPEQVSQRVWTARYGEWLEQELEAKKRELEKKLGEEQEKKEDRESKERLIDDTTLAEDNEAFFARRRDLRYRLKKEHHARKLLVSKIEATLGPLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGF4</accession>
    <name>A0A9P4UGF4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_427271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGF4"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000043">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="221"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2451039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="324" mass="35448" checksum="4BDB9933EFFDCBFF" modified="2023-09-13" version="1">MPSPHPYEALQSTKLSALRARLSLPQRFPLQTLARTLIHPSADPDPAFNNASLSVLGANLLGYYTAEHLLCNYPRLPMEVVFAAQNAYVGPRALAIIASEWGIEAAAEPGGEVEPGLLQFKRLRPGEGIPAALKKQVPWKWNVTQTHRIVATDEFGSPNAPPSPHSLASVPVPMEEAAQSFVRALVGSLHLHLGAPLVKRFFKSHFLSRHLDLSEMFDFRTPTRDLSRLCAREGFEAPVARLISETGRLSRHPVFVVGIYSGKDKLGEGAGSSLEEARFRAAAAALKAWYLYKPLDVTVPSSTEGELDTTKWKPNMVDCGEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGK7</accession>
    <name>A0A9P4UGK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 125 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_375195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGK7"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040261451" evidence="1">
        <location>
            <begin position="27"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="547" mass="60880" checksum="C14CA998BD2FD491" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGM1</accession>
    <name>A0A9P4UGM1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_478297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGM1"/>
    <dbReference type="OrthoDB" id="3642840at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="576"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2451249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1080" mass="122158" checksum="E3EDFC7E67991839" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH69</accession>
    <name>A0A9P4UH69_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_401699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH69"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08274">
        <property type="entry name" value="MDR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="49"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="392" mass="42092" checksum="C9A1C092AF701B9E" modified="2023-09-13" version="1">MPCIDARNQKHIYILSESLSSPTTKMTTQSQQHPEIPKTMIGVILTGHGGPEKLEYREDLPVPSPASDEVLIRVAAAGMNNTDINTRIGWYSKGFKSGTGTGTAKGQHADDASWSGVPLHFPRIQGADCCGRIVAVGNDVDPKRIGERVLVNTMLRHYVSRWPYECWTFGSECDGGFAQYAKAPAEETFKVACDWSDVELGSIPCAFSTAEHMLHRANVKAGEHVAITGASGGVGAAAIQLAKRRGAYVTAIGGREKAGNMLAVGADQAVARDGDLVSKLGRNSVDVFLDLVAGPAFSSLLDVLRPGGRYAVAGAIAGPLVELDVRTLYLKDLSFFGCTFQEDEVFANLISYVERGEIRPHVSKVYPLKEIGLAQEQFGSKKTSGKLVLEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHF7</accession>
    <name>A0A9P4UHF7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_493824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHF7"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2452134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="357" mass="39214" checksum="1D93A97D9F153A0A" modified="2023-09-13" version="1">MGGNGLGHVVAWYICTAAAVPFVALRMYSRWTRIGKLAIEDFLIILALCCFSGELAIQQHMWNLGLGDMPKVKPENFKGIIQMVVPASILYVSALWAVKFALVFFYKRLAAPGSRLVLLYNITLGGLVAMYLFIFFDSIFQCFPHDKQWSMDPKYKCGHIAFEINYWTTVLFNIFSDVVIIALPIIMVSRLQIKLKQKLAVAGVFALGFFVIIASIIRAIYSLRNKTMLTCTVSMAETAIAIIAACLPALRSMIIGGSTNGASSYGQHYELSSTRRKTQEPNRLGNSGGIISVASGSRTTKSHHNPNGSEDSLVKAGLSVGLDGRENIRVDTTIETMYDADTKSRAGSSRTNLDSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIA9</accession>
    <name>A0A9P4UIA9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_469153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIA9"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="58"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="552" mass="60997" checksum="492EF2BF0315B9CB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIW6</accession>
    <name>A0A9P4UIW6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_468511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIW6"/>
    <dbReference type="OrthoDB" id="5426563at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="611" mass="66594" checksum="2BE22CD05175B3FC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ50</accession>
    <name>A0A9P4UJ50_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_515340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ50"/>
    <dbReference type="OrthoDB" id="3756169at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="194"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="610" mass="69634" checksum="F0DA5251D6FEE409" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4B3</accession>
    <name>A0A9P4P4B3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_167820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4B3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="74" mass="8217" checksum="8799A1447B37D337" modified="2023-09-13" version="1">MEKLCPNRRLNSSACSSILFAHDLSGAVILVSNTFLSIIQLLILRGLLQAAAKRNTGTLWGAETQRILFYHVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5F6</accession>
    <name>A0A9P4P5F6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cardiolipin synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_458385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5F6"/>
    <dbReference type="OrthoDB" id="5193244at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040288202" description="Cardiolipin synthase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Cardiolipin synthase N-terminal" evidence="8">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="101" mass="10928" checksum="E8D53910BC794CDC" modified="2023-09-13" version="1">MFQFVLAALLQLSLGLLVEAAPVSAQGTNWQGPTGGGVVGFIVLILDIVAWVEIVKSNRPPLNKVIWALVVFLFPLVGMLIYYLFSNRAAHNDSGYEAIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5M2</accession>
    <name>A0A9P4P5M2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copper radical oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_436730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5M2"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF105">
        <property type="entry name" value="COPPER RADICAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040249408" evidence="3">
        <location>
            <begin position="26"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="143"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="468"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="581"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1199" mass="125245" checksum="1F8878134A42E061" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5T4</accession>
    <name>A0A9P4P5T4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_449594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5T4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="297" mass="31348" checksum="ECCE7718A5B88937" modified="2023-09-13" version="1">MFGRAVAGFARTTANATAVVYSVGPSMGSEAGTKVSTRQFLRETDVAGLGIVAHKERVDGRVCSGSRGCVSRDKESVSPRAVVSSGWQGEGEARRGGRGTATAEDGHTARRQVLLCGPVEDCQEVRRGGGSARRCNLDVRRRRAADTEPVLYSVRAQVISTVHTWSQCAPPACFAGAGWGLSVLQTTLQGSLHRANIHPRPQISALPPPSSLPLLVARSLRCLSRRAEDVWVVDSSPVGAAGEPAPEATAHRETGRPCLISFREGATLPRAPTWHPSADCRDGCLPSATDAPPPSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6R1</accession>
    <name>A0A9P4P6R1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_425130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6R1"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="51"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="609" mass="68962" checksum="5D1911C1BF6ED4C0" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P744</accession>
    <name>A0A9P4P744_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_477993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P744"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="181" mass="20543" checksum="B7B04722372C1EEC" modified="2023-09-13" version="1">MTPPRISQDLASLNQSDCVVDYDEDRRARGRAPTRDPMPTFLEIGYTCIEPSHPYLREIAHPHEIARQRELSRERHENARAQEDTDFLFTGAIAIVTFAGLAFAAYQFFGIQSWQERVLAKRRFPMSSIGAAPEWNGWAGMMESRPSSTTLFLISFLFPYLVSFQLFCNAGHRWNGIGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7M7</accession>
    <name>A0A9P4P7M7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAT1 multi-domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_166285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7M7"/>
    <dbReference type="OrthoDB" id="3777003at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27025" checksum="DC84E3671745BA2B" modified="2023-09-13" version="1">MVILGGLEIVAGGYLFHRYQRNKSEKKRLEQEAQQRRYNTFPGAKPQPCHPSHPQHAVPPQKYGYVAHAPPSRPQPPYPPLHRPSTEPPPHRPHNARHASQPQSFMIPRRPLPKQQHAPPPQMIQPLQRADSMATISRMPIANGYRPSHVADDPQLPPRRQNPQLSPIPQSPYGNPGFAVSSPAFINNPTTQTYSPTQHGGRQTMDDNWETYNNHAHYAPSLSTALGETRDDDPPPPYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P882</accession>
    <name>A0A9P4P882_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_367723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P882"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2440230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="336" mass="38604" checksum="88FB94102D12C79A" modified="2023-09-13" version="1">MSKPNPFLNLFRRCYSHQPLRSPTATRARPSPHPQCLRARFRSQFLLLRRNLGGAPNSGHTPLDPSFVSILDRPAKMARVGKQHGPGLIILAIIPITAFVLGCWQVQRLGWKTELVARFEDRLTFPPLELPLRIDPDAIAEFDYRRVYARGKLRHDQEMLIGPRMLEGEEGYTVVTPLEREDAQGNKSKILCCRGWIRKDAAKHWFRKKNGALPEEEITVEGLLRIPPKGNMFTPKNVPEEGKWFFPSVEEMAKWTGSQAVWVEETMTPDLLVNYEREPKGIPVGRAPVVNMRNNHTQYIFTWYALSLATSIMFWMVVKKPISGQTKRVRHSVDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8G2</accession>
    <name>A0A9P4P8G2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine nucleoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_370594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside permease that transports adenosine and guanosine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NUP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8G2"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="356" mass="38161" checksum="4E40E1E86B6C8743" modified="2023-09-13" version="1">MFDGEEEVWFGIPEFNILAQNITVTGFSPQFPAAHCTEDGSICQVVTAMGEINAAVTITSLWLSPLFDLESTYFLVAGVGGVNPMVSTLGSVALARYAVQVALQYEFDPRELPSNFSTGYVPQGSYAPNEYPGSIYGTEVFEVNDALRKVAAGFARTAVLNDSAEAVAYRALYDTPEGLYEAGTNPPSVVECDVTTSDNYFSGRLLGETFGNYTKVLTNGTGVYCNTAQEDNATLEALLRGHIAGLVDFSRIIIMRTASDMDRPYPGEAATTNMWWSNQGGYPPALRNLYLAGVKIIEGIVGGWNETFAEGVNATNYVGNILGSIGGTPDFGPGPVSLGKAAKSKRATKRSTRKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8M9</accession>
    <name>A0A9P4P8M9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_420150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8M9"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF100">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="295" mass="32230" checksum="C6BB6A83E248F40C" modified="2023-09-13" version="1">MPSWKRLIRFESTEGKTLRGEPILPSPDFDVGTTTEETGLKAKVIEVANNDIFDPATKVTDQEVTVKKLLGPVTTDEVPIIRCIGLNFIKHIQEGGRTLPPYPSTFIKANTCLNDHGAPIVIPKLAQDNQADYEGELCFIISKDALNVSEADAYNYVGGYLCGNDVSSRKLQRDPKLAGTVPQWNFSKGFDTYAPLGPQIVSTEVVPDPSKLYLKTIVNGDVRQSETIDDLCFKIHTIVSYCSQGTTLKKGTVVMTGTPSGVGYAMKEPQFLKPGDVVEVNINAIGTLRNTVEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8R1</accession>
    <name>A0A9P4P8R1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nonribosomal peptide synthetase 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_423402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8R1"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="56762" checksum="88B8E5000A336A18" modified="2023-09-13" version="1">MEVQNTGKAMVGPSSDQENGTRRPSHGLLYQPSTITLASDSSMSKVEDGNIGFIVGEVEMGQIKDTVELPKQWGNNFLRKIRYSWASSYRKTFALIFTVNLAVFVALVAKAPNGRPKHRDVGTAASANLMAAILFRQENFLNIIYEVFARAPHSWPLNIRKRVAKVFHYGGVHSGCGVAAVVWYILYTVEASILLVEDKNTHSDILANMVTSWVLVTMFIVILAGAHPSFRVRYHDYFEAFHRFAGWTALVNFWIHNVFSAAITARETGNTTGMALLKTPSFWTILISTGCTLLSWSRLRLRKVYPEKLSDHATRLHFRYAGMPSFYGVKLSDRPLLEWHAFATIPDVDEATGKTTGFSVVVSNAGDWTNKQIMASGERKLWIRGSPLHGLLYTSRLFKRIVLVATGSGIGPCLSLMHANITPTRIYWSTRDPQKNYGDAVTNAVQKADPRAVIWNTSTQGRGTIVQSVYELVRGSDAEAVFIISNPKVTDLVVFGMQSRGVPAYGAIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P954</accession>
    <name>A0A9P4P954_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_371217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P954"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="82"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="234"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="554" mass="59497" checksum="2AA4C1C1748B3A01" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9H3</accession>
    <name>A0A9P4P9H3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_421032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9H3"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="355" mass="37268" checksum="F1C878FC3B77AFA0" modified="2023-09-13" version="1">MSSQQWSRTLSSYLPWTSSPLLISAPMGGFAWAPLATAVSLAGGLGLIGSLNDMSQLSTQLSQARSTFAASSNAAIKASSTLPLGVGILAFICKIEDVVPVIREFKPAVVWLFAAKQLGDYRAWVDALRGASPETRVWIQVGNVEAALYVANHARPDAICLQGADAGGHGFEKGAGVISLVPEAADALRREGFGDVPLLASGGIVDGRGVAAALALGAAGVVMGTRFLASREVTIHPVAQAAVVEAEDGGQVTKRSKLFDQLKGPNVWPEAYDGRSLVVRSYEDYVGGVGLEEIQRLHNEAVLQDHKGYATGRKGRAAIWAGTGVGIVREVEGAADIIEKVRREAKRIMSGLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA67</accession>
    <name>A0A9P4PA67_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_93409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA67"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF56">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="33"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="353" mass="39289" checksum="1D2A394BCCED2636" modified="2023-09-13" version="1">MALDYASLTTIPISYASCSLGPPSSPPPLLDRLDAIAAASFTAIELSFPDILSYGQTVLGHSPDPKNYDELVKVAEAIKKECDKRKLGVMMLQPFANFEGWKEGSDGRKDAWERARGWLRIMQAAGTDMLQVGSTDTPLENLDLDKVVPDLQELCDMLKPHGFKVAYENWCWSSHAPDWKDVWRIVKEVDRDNIGLCLDTFQTAGGEWADPTTESGLLDDVSKIELIHRFSASLEDLSKTIPKDKIYLLQISDAYEVPEPLSKDVDESGLRPRGRWSHDFRPLPYSGGYLPVVDVATAVLRTGFRGWFSYEVFDGGPDGKGEKQNLVSYAQNAFNVQQRLVADCAGKKLPLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAN6</accession>
    <name>A0A9P4PAN6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_447903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAN6"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000283">
        <property type="entry name" value="NAP1-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="576"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="509"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="692"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2439933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="747" mass="81124" checksum="20B28E024B6114D1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB22</accession>
    <name>A0A9P4PB22_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_113185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB22"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040336073" evidence="6">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="29"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="253" mass="25152" checksum="4CAA097C70A7677D" modified="2023-09-13" version="1">MQLKNLFLALPALVAAAPAAQPQDLSVQIVGGSAATAGQFPYIVSILVNGYHDCGGSLLNANTVITAAHCATHSASTYTVRAGSLTWASGGVTSKVSRVISNPAYSGNNNDIAIFKLTTPIPTSSSISYVSLPASGSDPAAGSSSTVAGWGLTSSSGSGAPAALRYVTVPIVARSTCQSQYGASAITANMVCAAEAAGGKDSCQGDSGGPLVTTGTKTLIGVVSFGEGCALQGWAGVYTRVATQLAFINQNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB98</accession>
    <name>A0A9P4PB98_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_97497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB98"/>
    <dbReference type="OrthoDB" id="5337438at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001827">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="186"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="585" mass="64935" checksum="7F74346EAF1810E0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBQ5</accession>
    <name>A0A9P4PBQ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">KEX1 protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P171DRAFT_433652</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBQ5"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040320684" evidence="18">
        <location>
            <begin position="19"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="474"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="642"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="795"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="642"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2442075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="846" mass="92700" checksum="4F838EDA15380DAC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCB5</accession>
    <name>A0A9P4PCB5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial integral membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_433888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCB5"/>
    <dbReference type="OrthoDB" id="164921at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="551" mass="61508" checksum="1C822B0FE174B7FB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCG4</accession>
    <name>A0A9P4PCG4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_392365</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCG4"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040483408" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="371"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2442465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="475" mass="52253" checksum="23F5274C94B4524F" modified="2023-09-13" version="1">MRLWTVLTVLFIFGSSANAQAALQALAKQLPPCSLTCFMSEIPKSTCATNLTSECLCTNAALNAAVGACSMKTCTVYELFQTKNISSTSCGVPVRYSGRKFIVLGTAGVATAVLSFILRMAATLHGRQISWDDATMALVVCLAIPPAAFAFLLVDNGLGRDMWTLKDFQITNVLRYYYMGEIFYVLALGLSKISILFFYLRVFPAKEFRLQIYGVMALCGAYTIAFFFATTIQCLPVSFAWTQWDGLHKGKCNDIHLQGWIAAAINIILDVLVMILPLRHLAGLNMNIKRKLMVMSMFSVGIIVIFTSVMRLYSLVHFANSQNISWDYVEAGYWSLIEIDVSIICGCMPAHRMLIARAWPKIKLTFHSTKANSTNSKDSTAASRSTNAPATDKSVRVSVKPQTKDDRDFVPLVDIDTQGARTPKSNGPDSDRTEKWTSPTTKGISGSNFSAAESCESDHSDGWPMGKSTTSREHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCU1</accession>
    <name>A0A9P4PCU1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_434383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCU1"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2441751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="731" mass="83188" checksum="515E1722F191AADE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDS2</accession>
    <name>A0A9P4PDS2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_456562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDS2"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="263" mass="27786" checksum="77D30D5BDDE19B99" modified="2023-09-13" version="1">MEKDLEKNHDIYPTTSESSSGAPSITARLNSKVLRKEVTIVLGEFVGTFLFLFFAFAATQIALEASTINPSAPADAPKPPELHKLLYIAFAFGCALAVNVAIFADVSGGMFNPAVTAALWVVGLIRWDRALYSVAAQLLASVFSSSAISALLPGPVPFNTVLDPSVSIPRGLFLEMFLTAQLVLTILMLPSGGAKPLYIGMALFSAEMAGVFMTGGSLNPARSFGPAVVVGFQSYDWIYLLGPLLGAALGGGTFSLIKFLQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDU7</accession>
    <name>A0A9P4PDU7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF605-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_417115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDU7"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2442170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="410" mass="44422" checksum="5229BCA2AA3AF6C9" modified="2023-09-13" version="1">MAESIPAKLRAAQITPFVQRAAQLEPYKPFVTYWLRFYIIQKIIGAGLHTADGDCTTYTANLMDQLEQTKAANPDEDALHDETAAQAYCEQFAFTTFAKGEKDMTSNAVTKSTADTLLAAATFFEMLTIWKKDPEPEIKSKQKFAKYHAARILKALRNGEDPNLTNPVHEPPAVASPSVLDPNDPEVRNLAPDAPNPSARNPYQPYVESAPDTTAQPSPTISAPKVSPPPLLPSAPTDYSAHRDVSPISQPGNNSRQGSVVSEGGGYFPRVNVPTFTADTAAPNLPTAPSIQDEPMGASPFNPSQVPQHPQAPSPQDYYQNATSPAPIGQNTHQPQFNNSFAPQQQYAPPAQQYSQPPQSAVHQGPFKTDEEAQMAAAKHAKWAISALNFEDVNTAVKELRLALQSLGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDV6</accession>
    <name>A0A9P4PDV6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">STE24 endopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_434838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDV6"/>
    <dbReference type="OrthoDB" id="5341873at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9712" checksum="E2A677C7FAB355FC" modified="2023-09-13" version="1">MPTPIDRAVSQRGPFLAFAAIITGVAAWSIWGEDLFPSQDPKGDPATWTHEECVIWLKKRNLHPSPLATTAELLERIKANMRMATSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDY6</accession>
    <name>A0A9P4PDY6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_497648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDY6"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2441408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="497" mass="55236" checksum="52F841B451AE9BF2" modified="2023-09-13" version="1">MRAAKCRFHAVIERHGKEILVSWTKEEEAKVVRKADFLFLPLFTLMFTWMAIDRTNISGVLTSTFLKDTGMTRDQANTGVSLLWFGIVLLEIPSNMVLHRVGAHYWIPLQVITWGFIEVLQMFVKNTGGWYAARLFLGMAESGFIPGGLYTLSRWYTQDELAKRTTLFFFGPSLSAAFGSLISAGSLRLEGHGGLKGWQWIFLICGVSTITTGVLALAFVPKSPHDTDRLFAGTIPTRPWLSPREADIFVARIIRKDPRKGQAATMKITVKDIIEVLSDWKTWPYLLACLSGLQSVNGLSTWGATIIKSLGFTSIRANLLSAPAPIIASLGGLALSFYVDRYKRFGYAIIFTAVWTMAGLIALFHLPVTSQGSWAFYAALVITNAAPSWQPLNVTWLSLNSKTPQHRAIAYAVYIGCSNLGGTYGNQVFRGSDAPLYRNAWIACLSLGAVWLTVVILQVMGFKIANAKYADRKAGRTDGKDETLYTDAKGRQYLYYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF23</accession>
    <name>A0A9P4PF23_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_53177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF23"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="205" mass="23457" checksum="5D9356CB5B6396AB" modified="2023-09-13" version="1">MATNPEDGWETASDSGEESKSKASEIGQDVESINDVLQDNPNLKFGFVIYRCCTYDDQEKWDRFMKKLRRRTRLNLRDENAEHLYDRIDWCVQEDPKLASCSEAKVRSRFKKWIKESGEEQYWLPSSRFLACVMVDEHDLKSVLRGPSTEEFDADGSGYVTLVSLDKDEGHMSVGLSYLVPRVYALLESCGWDNFAVGDTDVACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF68</accession>
    <name>A0A9P4PF68_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_523754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF68"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="434" mass="46887" checksum="00498507109B84E1" modified="2023-09-13" version="1">MDDHELQAINPREVGVDSESVEQNLPRVDGGKDAYLVLASVFVQGALVWGFVYGFGVFQEYYSRQPQFAGNVSGLAAIGTTGSGIMYLTSPLVYGFFQWYPAWRRTVSLVGFAIMLSGMVGASFANSVAELLVTQGVLYGLGGSLLFFPVYSYLDDWFVKRRGLAFGVMIAGDGTGGVAIPLISQWMLEKWGFRTAMRAWAIISFLFVSASLVCLKPRPKARSTAEPISRGFDMRFLKSPAFWILQAGNICQGLGYFMPILYMPSFAAARGWPNITGTIAVSLCNISIVVGATATGWIVDRYHVTTAILISCIGTMVAVFIFWSFSVYQPMLFIFAITYGIFAGGFPATWSGCANPVRRRYPVENGMIVALFTAGKGIASVISGPVSGALVAADTWKGQVGFAYGSGYGYMIIFSGITASFASIGWIGKRLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFF7</accession>
    <name>A0A9P4PFF7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_446756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFF7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="378" mass="42178" checksum="59E511BD30F1F7CD" modified="2023-09-13" version="1">MRGRGRGEQGAGDISRDEARQERRTANGVKATDATIGIFCRNGYVGGTSLNSCLNFHPTLSLPCRNRYAIPTLPSIDVLIVVPFHGLASPLFVRITLDDTRPEIIRKIALLLPHSERLLLLLLIRRVNQRTVNVCDQLQNRTLLRKHVESVDDVLSRPRLSRCVFQDIVHERDADNTLQVCLNKKAIAQRVRSHHAAEDHIHVVLLAVTCVAEILDWPPGAVDPVDEDVEGVGFDVVQYYAAILGLFPYCVVVVQAGDEVRRVMCEELLVYDVRFAFRTDLDSYETLWALLGESAVECDGLLTRLLPRALTRTSLSKEPGEALSAEASGSCDSKILEQADRRESRPLGSLLFGECPIRKNSSPELISIKKEQAMILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGY5</accession>
    <name>A0A9P4PGY5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_486764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGY5"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2442784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="34340" checksum="60DA7973D0097395" modified="2023-09-13" version="1">MSSFLSSPPSSKRILELCATVKMAAECYANNGSLYTNSKAIYVPCNITAIENGEHSSCCAIGDLCMTNGLCMEQANEAKGANHYWRNGCTDKTWKDPACPNYCRGKEEPDHFNAFIFYCFEPKNEFCCTPQGTLEAGVTGRNTSCCNDEDLVFKANAPVVVGVAAAALPRISTTSSASSSASSTSSSRHLISTTSATAAVKSVTSSTPSPTASSESPGISSGAKAGMGVGITLGVLAVLAIIGALFFMRRRKANRHNNAVLLSDSKANPPPYVTYESAGTVRAELEGTMMPAEMHHGSGKTGSINAVSKEMGTTTPTKEDAAIAKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHF9</accession>
    <name>A0A9P4PHF9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHF9"/>
    <dbReference type="OrthoDB" id="3920320at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="119" mass="13597" checksum="63454FB62C9CE507" modified="2023-09-13" version="1">MSPRRETVVVEADPPAYPGGYGTIRTVEVHHYHTGPRGSCSRAFMATALLLLITFAFSAVCFVAWNFYNLSELLTDSRAAEFYHASFHFALTLFWKKKTWLLYACQTKLNQYFCTAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHT1</accession>
    <name>A0A9P4PHT1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_432445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHT1"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="3">
        <location>
            <begin position="97"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="746" mass="83164" checksum="0DD5E6757EC210B4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIX5</accession>
    <name>A0A9P4PIX5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_431637</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIX5"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000141">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000036">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="11">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2444842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="368" mass="40245" checksum="F40E6466077374DA" modified="2023-09-13" version="1">MSLGVPSFAPDGRQLSPGEVWEETTSAPKQQEWREDLNVLLICPDCREVPPNLVENFSRGDTVCGDCGRVLSERNLDFRSEWRTFSNDDQGNDDPSRIGDAANPLLHGSQLHTEIAFGDASNRHRELSRAQNKSNQDKTNKSLSAAYASISHLCEQHSMNKVIAESAKLLYKMTDDGKLFKGKSQDAVIAGCIFIACRQHGYGRSFREIYKLTRVSKKEIGRTFKILEAYINKKKKEQDGPKAAGSGAVINAGNFNLTKATTASELIGRACSRLQIGKLEMIAKDCANKVNTLGVAAGRSPLSITGAVLFLVSHLMGSPKSPKEIGAVVDVSDGTIRTAYKLMYARLDEIVEPAWIEKGGDKSRVPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJA7</accession>
    <name>A0A9P4PJA7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_359445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJA7"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="52"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2445095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="505" mass="55291" checksum="B676BDB31B140DB5" modified="2023-09-13" version="1">MPVSDEERTAGESKPPQQVTKIRAPPNRNLVDWEGENDPSNPLNWPSWTKTVNITIILMMCVTHASAATAFIPSIGSIQEDFESDNAYLSAFIVSAYPLGFTAGPLLIVPLAEILGRVLLYHLCNLLFVSFTCWCAVTKSLGMLALARCLAGCGGAVTVSLAAGSMSDMVQGNMSRLLLIVVGLAIYLTPAISPLVGSHIYFKWGWPWIFWISAIMGGICTVIGFALSETYEPILLINEATEWRRRTQNWMLFTPFDEHPNRIITTRCRNAFRQPLRILLSPSFLLTSFLPAAGFAFLYIVYITLPRAFLSVYTWPSMDLGLAYLGIAVGIIIAVASGAAASEKYAKLRAARNDTRAENRLIPLLCFWPLTGLGLFLYGYCVHQKMHWAGPVVSLGLVGAGVMFSIQLNSLYLFDAFPTKSTSAIHASLLLQSLLGGVIPLFSHKLYEYFSSPYMFYFLGGIALPLTIVPGIFYLLRRGEGPAWAGNPRGECSARTACGSPSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJE4</accession>
    <name>A0A9P4PJE4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate ion transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_253752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJE4"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="488" mass="52760" checksum="295E82579DF5A293" modified="2023-09-13" version="1">MWDLGFTAFGGPPVHFQILHRRFVEGQGHFGAKWIDEQTYQELFAICQALPGPASTKMVFCIALMHAGFAGAVWAFLLWSLPGAAGMYALSLGVQKMPDRLPAIVYALLSGMNASTVGIIALAAVQLAEKAIKDRITRILVIFGACAGLCYNALWYFPVLIAIGGLVTFVWDVWLRQRVAKMRASYVAKRRARTEGGDAEETVASEQVPPAEQIQLERPEAVKRRLPAGNSADRILPVEEERGPSRSSERRNTEPTPAATPQAHTISIKIGLSLTALFFLSFLVVMVIRGTLPSRALAYDLFSNMYLAGTIIFGGGPVVIPLLRSYVVDPGWVSPRNFLLGLAMIQAFPGPNFNFSVYLGALTLAATRIPTIFGAVLAFVGIFTPGLVLAVGVQSIWQVVRTKAWVLSLLRGINAAAVGLVFTAVYRLWGIGYLTAESNDGKSLAEEPWWVVVAAVTYAETAWFDVPPALAIIFGAVLGVGWYGAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJE9</accession>
    <name>A0A9P4PJE9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_521120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJE9"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="316" mass="35344" checksum="86511310023EF772" modified="2023-09-13" version="1">MTSKTNDQLRPTSRRGASGAWRRGDRLKPAPADTLELYGLPSKGETRLNDFRTQEFYFSKLIERYMRLCAINEKQLSALFASITLTDAPTTTPLGLPLPSAPPAPPDALPSAPPTFNSPPINDLATVLSAFRKLREAITATSRKDAFARRAYFFGIHAAVLCKDWASYLPALNYLLAALHAATPLSPPDLKEYVSLLVLDQACRQGDIALAHETRLRFNLKDRRVDLVLKALVADNWVVFWKMKKAVDGYQRSVMEFAEQGVRVHALKCLGRGYLSADKRFVERSADREWAELVKDGVGWELTDEDKVVIKKPKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJI4</accession>
    <name>A0A9P4PJI4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJI4"/>
    <dbReference type="OrthoDB" id="5181940at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="191" mass="21159" checksum="BD54195A56F82CD0" modified="2023-09-13" version="1">MTATKETPDVHAIKALIQSFFDRINASDAKGLATLFLPHANLSILRQDPARDPASDSPWSSVLLPHNAVPTTPHNADDEEKVTVVLRTSIEKFVPMIEDGEKRRKGKPGPKVHETPDLDATDVKVDYLFGTAWSPFRVTFDGELHHYGTFSFTFGKVDDGEGKVWRVEGLTQNYRRATGWGEGNELAKGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJK2</accession>
    <name>A0A9P4PJK2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_413371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJK2"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2445230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="406" mass="45773" checksum="0F725AC692439B46" modified="2023-09-13" version="1">MDDDLPATKTAKLSCGHRMCHSCLKRQFTLSVSDPKHMPPTCCNAEHIPLQKVERLFDDKFKRQWNKKYEEYTTANRLYCPTRGCGEWIKPSKIRMDLTYGRKYARCGRCSTRVCVLCSGKFHTKRECPKDEETNRLVEMAKEKGWQRCYNCRAVVELKEGCNHMTCRCTAQFCMVCAAPWKTCNCPWFTYAHIADEDRLNDMRVPYHDVVEVVEVPSQPDAVPFRRASTRSRRRPERDLDRAGDILAAHLQAQLRMDGPPTASELNRAVPAVGVYGLGNSGGHHMNESYAVRPLATAAARTATRSAAPRSFFSSLRVAREAPREAPRAAPREAPREAPRPQVVHTVQTVRASAMAGLSRDGSKRGANRVGTWLSHVSVDEEAIHTAARDVEVDDWRIDGSVRGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJT7</accession>
    <name>A0A9P4PJT7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_359299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="TesA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="383"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="1287"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1640"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1764"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1287"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1444"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1598"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1720"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1841"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1724"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1851"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="1319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2444613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="2121" mass="233154" checksum="CB6FFDCEFA2D65A8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKW2</accession>
    <name>A0A9P4PKW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_356175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKW2"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="513" mass="55827" checksum="B35EAD770E693BD4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKZ2</accession>
    <name>A0A9P4PKZ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_511757</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKZ2"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2446116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="508" mass="55256" checksum="AB10918B5CAC7BAC" modified="2023-09-13" version="1">MKQRITYLVEDPDSFTPEQLEVKDGSLSLRGLKAVQEHRITFSLDELPTELRTTLKQWQELHIKWASLKPYTAIPPFTSRVSPGLHVSFTPHKSQPKGQLCDLLHTVFDPAAKCSSGTDADEVATPLIHADEDGNEKPSASLQYYSYLPTLNKLASFIEETLCPPSSTTCIEYATSLLEASYLDIDYSAPAPILTLTALSTPPPAGWTTILTSPHSIHTTEVGVLTHEPNPDPEDLAFAGFLTVLGPSAAPKPTRFQAPARHYPLSASPGLSYTARFTHPTGLHPTLEVSFDGKLEPPAESCALYTYLTLPSYLFIDKYQFADPLFLSAQNLVALQRVSGATDLEAPDWVVPQWGSAALFELAVPPPPEEDAKDKAAGGNWTSRIPLHLRYLPASPRSHTPVPVPWPVVFWGCAAEQDSAGNPFDRVNLGYDGAFGAGTRFMHVPPEASGNGTGELVSWIDVPVLDTSAAGWVETGTIGVVVCAFVGLCWVLFSDRGKQEIKAEKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL40</accession>
    <name>A0A9P4PL40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF602-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_520988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL40"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="304" mass="32910" checksum="43528355F7457A85" modified="2023-09-13" version="1">MGNDGGSIPKRRELVKEAAKAPTAAQIKEARAESQDHAWNHCPLSSKPLAAPVVSDCLGTLYNKDSILEFLLAEEGSAEKVEGEKVLAGRVKGLKDVVEVKFEVEGEADKGAGRKEKWVCPVTRVEMGPAAKAVYVVPCGHAFAGSVVREVEEKVCVQCNEAYAENDVIPILPTVPADIARLNLRAKTLKEKGLTHALKKAPGSKKRKKTADASSAEAKATTSEEDKKAAAKPEKKERQADNGIQNASTAYLTKKVLEEQEERNKRRKLGQNDNVKSLFSKGNKKADLANSKDYMTRGFSIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLB7</accession>
    <name>A0A9P4PLB7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_430114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLB7"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2447204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="486" mass="55440" checksum="161DD0A8B42C06CA" modified="2023-09-13" version="1">MPRYPLQDTCLAVITFAPVLASVFVALRIYTRRKLNLRLGWDDWLIVFPTILSLALIGPSWRHVKMWHVGIHIIDVPPNDIEPDYDEYHQILLAFNLLNIPILPLVKASIILLLLRAGSVIEWMKKTLYAILIFTVGSALIPWCLYIFICPPQTGNTWKPRTFGGLHCMGRHRMGEMLIWVTCANLLTDLLIFPIPFIIVRRMMSARLRSRLVVLAVFTSSLAVTAIGGAKIYLTYRDRLFTSFKTDWTYPIDYCISHIENNVAIIVANIPILRGLVTRWVFNFKTKPTPIEREFRSEWQWSNSNSSTITHVASRKRRFLNKIIPCLTDDFSSSLARSGDFIEPGKQSSLKPAVLRKKTRPSKSRSHKPSRRNSVDRYEKADCLEKGDVLETVMSVGSLGSAPTLVDHHREIEWRLSEVTMASSPRRPSEATFSSNPRRTSETPLLITSPRRVSNATLSPVLSPIVPLSPVLLREEEDEDEILRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLV1</accession>
    <name>A0A9P4PLV1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_444079</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLV1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040135463" description="RING-type domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="349"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2445196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="542" mass="57056" checksum="E211DA443DA33B79" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLZ9</accession>
    <name>A0A9P4PLZ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_259437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLZ9"/>
    <dbReference type="OrthoDB" id="3799185at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="182" mass="19881" checksum="05E086090EF67CF0" modified="2023-09-13" version="1">MMNNNPAIALYAPYRRLFASNATAHESILVSPPIHPVLGVHPLMSSRHYTLALIAVIGLLSEVLCVTLSAIPFNPATLYTAYNVSTWVSVAILILMLLALLFVFFYQEPVMPIKPDTVAGNLVYLCDGSLAEMLKDLGGHTTKERNEHIRRMGLRYEMGYSPGPGGSRLVVLAARGGVTAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMH4</accession>
    <name>A0A9P4PMH4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_238024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMH4"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF11">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51519" checksum="DA31622F8F7986D4" modified="2023-09-13" version="1">MYLLTRLRNNKACCYDYGGTPDSLSLTQTTESPVTYSPLHIASTASIGSLHDSRVLDATIAREVVQIIDATRRSIDDISARYFNGIHLWVPFLCPDRFSKDLFQFHAVSTAEFSLLLLCMCLATYDPPEDLPPPVDHNALYFHAKTLFTQIQVLRKPSTHLIQAGLLISVYEYAHGRPGVALASTDLCARMAYRIGINKKHTSLGWSEEWNTWWAIVIFERIFYCESTLADIPLVTVAPDETALLPHEVGDCDREPDLNPGFRIAPVSQAGVGCLGRAAQAAHLLGRVIQTIKTISFTTADRIANLIYLDGELQRLLSVTLNKCHGLRGGYCGAVGAAIRALSMLHRHILHLEATTIDSKWRNHSQAALDTVAQMIVDISRSHRDIPYSKIDIISPASSYLIRHALQHIYVKRYTDSKAWFDDSDALRESLAKLDRRWSFEMGTFSKTEMTSSVTSIDVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMV8</accession>
    <name>A0A9P4PMV8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMV8"/>
    <dbReference type="OrthoDB" id="3793493at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040160458" evidence="1">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="192" mass="21202" checksum="79084C8026378AA9" modified="2023-09-13" version="1">MRAFAILSGLALASATVLIPATQADKPGHLTYGDVQLDLKAGCQTVPQNKDDGLPKPSLLFTKLQVNGDYTCELYREPQCVEAFWTVDGPGVKAEYVDGWLFSAKCTANPRVEGRVEPSCGRVWETDHLTGQSYWLHHTGGGLHRFNFKARSAKVEGSCQCTFYEKFPCRGIGWTTSQFAGDLPWAAECYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNG7</accession>
    <name>A0A9P4PNG7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_260937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNG7"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF23">
        <property type="entry name" value="JUVENILE HORMONE ACID O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="77"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="222" mass="23746" checksum="35A19A8D4A0F48D1" modified="2023-09-13" version="1">MAATANKNPVTTNIEWLNRAYSAKGLTDLRSLYDEWAASYDTDLVQPNQDYVAPALAAATLAKHLGPEQPLDKIQILDAGCGTGLVGAALSKLGAKHISGIDLSPGMLKVAGNLHVYTNLDTTDLSKPLEEGTDTFDAVTCIGTLTHAHVGPEVLSEFVRVTKKDGWIVATVLDDIWEEIGYRAEIDKLVANEKVKLVSADSGDYRRGAGVSARMVVLKVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNL7</accession>
    <name>A0A9P4PNL7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell cycle control protein cwf14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_357497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNL7"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="149" mass="17201" checksum="330777B2E7032AFA" modified="2023-09-13" version="1">MPPVRTARASKKAPPEGFDDIEDTLLEFAAAMKDAENASHDGKKKYEMTWPIFQITHQRSRYIYDMYYEKEAISKQLYDWLLKNGYADAMLIAKWKKQGYEKLCCTRCIQTKETNFRSTCICRVPKETLKEGQEVQCVNCGCRGCASSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNL9</accession>
    <name>A0A9P4PNL9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_462735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNL9"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="75"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="395" mass="43055" checksum="3405DB6C8A681B72" modified="2023-09-13" version="1">MSDYEDEMDVDAPAADTSIVFSGDAKKGKRSAANLPVEAEDSLPWVEKYRPSSLDDVEGHKDIIATINKFVDSNRLPHLLLYGPPGTGKTSTVLALARRIYGAKNMRQMVLELNASDDRGIDVVREQIKTFSSTKQIFAAAPKPGEASSLATFKLIILDEADAMTSTAQMALRRIMEKYTANTRFCIIANYTHKLSPALLSRCTRFRFSPLKEGDIRNLVDKVIEEEKVNITQEATESLVTLSKGDMRRALNVLQACHASSTPLQPPGKPAPDPSTIVRDQITQTTIYDCIAAPHPTDITYILNMLLETGDITQCLKTINTIKTQKGLALADILTALSEELVKNEVPSQTTVTWMSGLADIEHRLSSGGSEAIQTGATIGVVRTGVELLAHGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNN1</accession>
    <name>A0A9P4PNN1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_519972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNN1"/>
    <dbReference type="OrthoDB" id="5418867at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="126" mass="13866" checksum="E1C10C3F44CEEB39" modified="2023-09-13" version="1">MVKWDVNKDRQLLLEVLAYMDIKIEKGLTEHLANAIGEGCTPKAVARRIQKLQSATRPKQPPTLGPLSPSTFHTAKTSHGADMKIETGGKANLQTKGGKRGRSGEEIEGMHKKTKKIHEEEVDGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNP2</accession>
    <name>A0A9P4PNP2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymeras-like protein I 49 kDa polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_357447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNP2"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="441" mass="49139" checksum="907057C10A84F4BC" modified="2023-09-13" version="1">MASDKKRKRQEQGGERPSKKPAIAPVQGNVKVEYVDNDEMLGPIIASTPGLKFPSQITFKSYKRTKVLPEGSHTDLLLQSSAHSRLDYIAREEKDGSAESRTKDYVGVYDPATGKMQLMPVKRVTVRSSLRSEAEELHNRQARIEAAQSTFTAKRHALAAEFGSKRSRKAIEDMTQNAIQRGDATKDEGIADNVLQGMSGATAAMPTTEELAAAVDESKPRPKANIAAEYPIDVYTVDNVVGKELMALIEVNDWVSASESGAGVEVRSRFVAKRISKLVKNKQYQKLKLLRFILLCVKLNDITKTTKQSGLKKIPPKGKFETAMGDDVPASVGNTIRRKFASETNELPRWNIDNLMTHACAAALMVDDFEVDVNDLREDFKIENKQIKQYFSELGCRLNVPTEGDRTKLKITKAESNSHTIAKLRLPLRFPTLRRGPPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP75</accession>
    <name>A0A9P4PP75_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_408095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP75"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="382" mass="41904" checksum="EACE9FD927521B29" modified="2023-09-13" version="1">MAKTKPQDRARKAKKDAKNGAADGAKKPKTSPETLLVQAAALLQTSQPDEALVAAKRALNLLQPTSEPTLAALPAVNLLGEINVELGDPDSAREAFLAAIALDMEGVHDGAEKFLWLAQLNEEGGAESVRWFEKGVEVLKRELSELEGKIVKKAEIADALAEKKQKIANALCGIAEVYMTDLSWEAEAEARCEAAVTEALLVAPEIPEPLQTLASIRISQLRVDDAKAALTRSMALWTDLEPDDPSIPDYSTRISLSRLLMEADMEDEAIEVLERLIGENDESVEAWYLGGWCLNLIAEKQKASDDVERIAPLLKASRDWLENCLKLYAAFEYEDERLKAHADELLKELHGVVGPSTGEEEEEEEGEDWEDADDDDAEMDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP79</accession>
    <name>A0A9P4PP79_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_482928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP79"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="35"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="192"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2446848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="365" mass="39908" checksum="0D50E37B708B15B8" modified="2023-09-13" version="1">MPYPETTDAFAVTDIKNGNWSTFKRQELPLKKFEDHDVDIAIDACGVCASDVHTITGGWGEEIPLPLCVGHEVIGKVVKVGSKVKDLKVGDRAGVGAQIGADLTCNNCKADQENYCPNAIDTYGAPHPDGTIAQGGYSSHIRAHEYFTFKIPDNLETSLAAPMLCAGLTTFSPLKRLGTGKGKKVAIVGLGGLGHFGVLWSVALGAETYVISHSESKKDDALKLGAKEFISSNKEKWFEPYAFQFDIILNCADATDKFNLPDYFSTLKVNGTFHMVGFPDKKLQPLDAKAFAPNGCYMGASHIGNRPEMIEMLELASKQDIKSWVDTIDISEEGCKQAVERVYKNDNVRFRLTLVNFDKVFGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPV3</accession>
    <name>A0A9P4PPV3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_207663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPV3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="253" mass="28219" checksum="4C0C0230F0ADC61D" modified="2023-09-13" version="1">MSTGATLVVEMMVIFAIEFSAKTTIDVLSWTRLLGYLHAEYHVQSAGSFGIRLRRVAHVNEAAQVRVPPLGDIHTQGQTRFQSVSVFLGTLQSASRRETRGSTPTAPRTGIFFRRRRVAHVNATILQRFWGLRVRHFSDQGPEGTRVAFLPSANHEREGWNGAYVRGSGVEKLGLSSGWVAAGVDRSGRRDGERWRQNEVVDKGRSSQIWRYETGSRGTCSGWAAELMQTRRWRGCRLVSGAVGCERSRGKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ76</accession>
    <name>A0A9P4PQ76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_212192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ76"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="174" mass="19007" checksum="B644D9A44C042193" modified="2023-09-13" version="1">MPTAPPATSRSFWRLGSQPMHRHLDSPGAEESEAFRQCPAPRTLVLQPMNEENVFAAVKSSPITTPLMLCCGSRNLRATTCATIQNRPFSTRVDNHVVARKRWNAPLSLTAFLVLARPLRQPATVLDAGPSLLIAVAGCPLRLRRCNQPLASAYLFAYSTKTDRPAGPGCTLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQS8</accession>
    <name>A0A9P4PQS8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_213397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQS8"/>
    <dbReference type="OrthoDB" id="5343383at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="297" mass="34747" checksum="4BB0A54368AFD371" modified="2023-09-13" version="1">MSALSNRPDQNEESKSEGEHANEELGEKQEESDEDEEEEEYEPRYSVKELAEMVLDFYSFLATLHYDPSDLKIPPPVGWPVECLPKGVMRRKSPRTVELMRHLPYFEQAEKSTHVHYKCMLYDYTDATEHDHVRERDKNYFESVGELESIDGDKLDPADMLILAWGYESGGHYLLLDALRGEMTVDVVRYHLLSPEPIEDFFSDLKEAYRSLKLIPCPGRETEEAAWVPEGGQRIEQSAVLAQEDKWGTELDWQFVRQVYREHGWPDAFRRKEAVRAIEDLMALKAEERDTWEEAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR09</accession>
    <name>A0A9P4PR09_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Modifier of transcription 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_427878</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1340"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1694"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="712"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1860"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2449709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1929" mass="213410" checksum="2853C1AF8C0B8570" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRH8</accession>
    <name>A0A9P4PRH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_185967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRH8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="83" mass="9100" checksum="6BFA67D0ABEB21B2" modified="2023-09-13" version="1">MLVLLRWLCQHLFCRQPKSIRPSPRRLSYLYPLDLVAAVLLWCPAMSLTAQARAPTPVSPMTSRAGTATLSYSTATATAQPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRI4</accession>
    <name>A0A9P4PRI4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_405622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRI4"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="477"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="877"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="850"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="964" mass="108288" checksum="8002B835E08BEB52" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSB6</accession>
    <name>A0A9P4PSB6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7624 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_426809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSB6"/>
    <dbReference type="OrthoDB" id="5230484at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056041">
        <property type="entry name" value="DUF7624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24616">
        <property type="entry name" value="DUF7624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7624" evidence="2">
        <location>
            <begin position="599"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="723" mass="80470" checksum="669415F0D53742C0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTK8</accession>
    <name>A0A9P4PTK8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_504013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTK8"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF25">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="311"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2451120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1156" mass="126448" checksum="60553F7292EBD89B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTQ5</accession>
    <name>A0A9P4PTQ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar import and degradation protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_428119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTQ5"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2450012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="80255" checksum="01E2205EC447F49F" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUA3</accession>
    <name>A0A9P4PUA3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Folliculin-interacting protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_346716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUA3"/>
    <dbReference type="OrthoDB" id="5428015at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Folliculin-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="77"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1220" mass="132576" checksum="AE37B648A74A864D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUX5</accession>
    <name>A0A9P4PUX5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_439459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUX5"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="65"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="445" mass="48911" checksum="3DAD5A7E2A1519C7" modified="2023-09-13" version="1">MAMSQAALKAEQAIGHSDNATTVQDVTNPDTAPNAAGEGTMKALAWMGKNKVEMIEVSKPKIMEPRDVILKITGSTVCGSDLHLLHGTVVELQKGDILGHEFCGIVDEVGSEVKKLRKGQRVVASFQIACGNCYYCDQKLSSQCEKTNSNTIENAMYGGRTAGMFGYSHFTGGFAGGQSEYTRVPYGDVNLLPLPDNIPDEKGLYLSDVLCTSWHAVVDTGVKKGDVVAIWGAGPIGQMAAEFSLLNGASRVIMIDQNWRLDFVKDRYPHVDTLDFSTLGKGESVTSKLKEMCNNRGPDVSIECAAGEYAKGWAHYFEMMLGLETDTSELINEMITSTRNFGRCGITGVYVGFTNHFNIGSLMERGIRLIGNGQAPVHLYWESLLKMIEDGQIDPLKMVTHRVRLEDLDKVYYKFEEKADGMQKVYVETKFSAPACEGSPELKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVF3</accession>
    <name>A0A9P4PVF3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_324263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVF3"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2452109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46569" checksum="7BA2A320AB471B3C" modified="2023-09-13" version="1" fragment="single">MRLIDVDTLEIKAFSEQDVPGYAILSHTWGPDEVTFQEMSLITRMRSVSQAFTSQRSDDSQEGDVSSVYDSGAIMVAMEMLVHGGWGAGMNVPNTTEEALMGREGYRKIVQSAKEAKNLGYQWIWIDTCCIDKTSSAELQESINSMYKWYKESSICLVYLNDIAPGVAAAIDTQATFEAASNAFTNSRWITRGWTLQELVAPTALRFYYQDWTLMGDKREFVEELSDASGIPIFVLDNGDLSELSIAERMSWASYRQTTRIEDMAYCLLGIFDIQMPLLYGEGEKAFIRLQEEILKTTDDYSLFAWRAVTPESSSPSKSVYRGLLARSPLEFRDCRSVERETTACNVPMSATTIGLHLELEFLNDPKDRTRFLVLIRCNNSLNQRLAIYLKCLDNSHQYARVEAGSLIPINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW59</accession>
    <name>A0A9P4PW59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_439096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW59"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="142"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2450448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="306" mass="33566" checksum="93971F66D905D7EC" modified="2023-09-13" version="1">MLRDKKDGQVEETQLITYPDGIVQGWSQITCHPGSQAIKGRTEGVGVRFCKDCLQLPRSSAMHLWLVTSPSQPKDEVTGAHNPMKSNLDWGVFLTAGSVADAAPRVRQRATQLMRDENAMIYRQLDTTVLSAGDGGASAGAKEIIFSQLPKTWKEQDLETWLFHSNSLKVVEYDMQKNGSGGLIGMGTASFRTGNDAADAVDALNGQKLVFTGGETTAVVKINQAVIHGESWGARLAVPARQSKKKEKKKRKSIRDLSSYTPPGCTRRNRLLIRKAQCATPTNLLIEVCFLPYLCFPAYNICPVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWL4</accession>
    <name>A0A9P4PWL4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_478643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWL4"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="131" mass="14441" checksum="EA7D00ED5E633E13" modified="2023-09-13" version="1">MSDSSAPQKKERFAPKQLVNLAPPKDDVITRDYLAKCDGTNGGFPTLVAIKGDVFDVSGKDTYAPGKNYHVFTGKEPNRALGLSSLEPKDCISDYSGLAEDKLQVLNDWHTFFSKRYNIVGRLQSENNASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWN0</accession>
    <name>A0A9P4PWN0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_459576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWN0"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF41">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2451587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="501" mass="54466" checksum="BF1ABC5C75B98E48" modified="2023-09-13" version="1">MVKSKYYGTDSDRHEMEMLGKQQVLRRNFGLLTMLGFASTCIASWEGIFTYLNFVLIDGGTPLLFWGFFGTATCMTLVYASLAEMSSMSPTAGGQYHWVSEFAPRKYQKVLSYYSGWLTAVGWQVYLASVCFLVGTTIQGLITLNNMNYGYERWHGTLLAIAVVVFTISFNTVFASKLPKVEAVALVVHISGFLAIIITLWATAPRRSAADALLNFTNDGGWSSTGLSAMVGLLAPTAVLVGYDCSVHMSEEIKDASIVLPRAIMGSVILNVSMLFVVIITICFTLGDPEEVLASPTGYAFIQMFYNAANSLAGASVMTFIIIFMLAICAVSEAAACSRQIWSFARDQGLPGHRWLSKVSPHWNIPLPGIIVSLSISTLLSLINIGSSVALGAITSLGAVATLISYYLTIGCLVHRRLCGAPLPDRRWSLGRWGLAVNIGALIILTPLIFFLTWPLSTPVTAETMNWSSVMLAGVFIISTTYYAVKGKKEFTGPVVNVIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWT1</accession>
    <name>A0A9P4PWT1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell surface spherulin 4-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_376037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWT1"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF7">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41025" checksum="434B257804CA8482" modified="2023-09-13" version="1">MLSVPGESSSRRYHPPHSPASSHGRFSSAGSSRDAPFGTSSGDIPLQQLITGAASSKPSRPLHTSTSNLSLQSWPGHPRQPPKRQRRHIDDHVLALSVTITLAILVLIGVPLGAVLPQRYVVPLPINVIVPFYVYPDQDAWDRMFQAAIKHPETNFTVIVSVDHGPSPSAWPPGAYLAPIKRLNTLPNVQAIGYVDTDYGSRDGEKVRKEISTYAGWNNTDLAISGIFFDHTPAEDVDDARIYLKNVSATVRHTEGFLEPTIVVHNPGKVPAANMTNYHADVTVVFEGAYKDMLTRDETKAQLRELGGSRHDYAEVIHSVPRTMSRGGIRRIINGARRNIGWLFVTDRMGDNKYEWYSDRWEEFLNLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWY6</accession>
    <name>A0A9P4PWY6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_348808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWY6"/>
    <dbReference type="OrthoDB" id="2359117at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039198">
        <property type="entry name" value="Srl3/Whi5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246:SF1">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="404" mass="43424" checksum="8FCCEA734577F699" modified="2023-09-13" version="1">MPSLYQRELPDSQESYISAASSTFSAPRLPSASSNLSTSTAEDTEITSPPLSKTSSAQKTPIAHAIPPSPNRSRGPDTLRIDAANAPRTGDTAASPMPLDSPAMQGLKRAADGSVKGSDTVNESHAVPSMGHKRNRSMEAGSSGRIGQLSAQLKTRLSYAMVKVQNNWEKQSLDELEERISQQGSPNSVANRTPGSRPFFESPTTAERHRRPSGVSENSDHMILSPGQRTPPDHSRYHASMPSSLWRPGTKPTLNAAVSLISVTGSNTGLVLGPAPEFESRRKRRSSASLHPPPLLGSSQRKHFSDLGAGPRTPATPRPGILRMPSQQAEKDAVDTLLFMSSPNNSGRLPHTSADAPAQRHDFAPPQRRVMFEKFPSTERAAGHLHNSAPSSQSAAYYRAEPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXM5</accession>
    <name>A0A9P4PXM5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_152342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXM5"/>
    <dbReference type="OrthoDB" id="5231252at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040285192" evidence="1">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="115" mass="12004" checksum="72C397E3981EAF6D" modified="2023-09-13" version="1">MRFTIIAAAAFSTAVFAVPAKRDPQSDVASILAALRTNNPDDATAAESAVTKREAQEDDLNSILAALGENNPDDADAARATIQKRQDDVSAILAALGENNPEDAAAAAGLNKRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5I3</accession>
    <name>A0A9P4U5I3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_436441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5I3"/>
    <dbReference type="OrthoDB" id="21018at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2439084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="204" mass="23183" checksum="B329D6CAC16827AD" modified="2023-09-13" version="1">MTDASSFSQSSPCTPSTTLGVAFLDLDKDMSLFAGDASEEYQYEIYRYMRGAVCYNDPLRFEHPQESEADQPRRSPRKTAQHIRFDDPDPSTRRIPPAEIWRSFHPKTNLVWAHFILYKLLEHLEGNEPSNLSSTQIMRNVEASSEEKTQVARKAMKLYKVLERVAELLEPSALGKKDSVGSMKELAVLAMEERWLRVGDVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6Q8</accession>
    <name>A0A9P4U6Q8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_160178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6Q8"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="285" mass="31981" checksum="90BF7C247D2FF1BE" modified="2023-09-13" version="1" fragment="single">TVKDHSTSPKANGCAETAKQFLKHNVHAQDWILALKHNVVPALLGLLLVSLPNLKALRCSALWIMDFPLLTSLISAKVTSVPINHSHILFTGRPSALFNFSSFEKLKNLSMSMEAIYYWDSRPRLPYPWPMPLLPPNIQTLQISEGTESTASFIEDLCKVKKEGTSFQSLCLIDVFFSLPYDFTVIAPACLRTVCSDAVVSLSLYFPGFPITTPEVDRNLWSLKEERVMVQIGWEKFSKENPVANEVTPYDWARLIAMESYGCEPSAEKDINFDAEGDIEMTSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U724</accession>
    <name>A0A9P4U724_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_458701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U724"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="139"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2438607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="626" mass="68748" checksum="DF3F29740DD07D18" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U800</accession>
    <name>A0A9P4U800_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Opsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_335762</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U800"/>
    <dbReference type="OrthoDB" id="10261467at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00327">
        <property type="entry name" value="BACTERIAL_OPSIN_RET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2440376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="287" mass="31196" checksum="432F7D6FD774CA17" modified="2023-09-13" version="1" fragment="single">TATASHTSLPTVFPDPIDKQFVGDDGKRTLWVIFVAMTIASAAFAALSWRVPIQRRLYHVITTLILITASISYFAMATGHGVSVHTTIVRHQNDHVPDTTTEVQRQVFWARYVDWALTTPLLLLDLSLLAGLNGAHILIALVADVIMILTGLFAAFGSEGTPQKWGWYTIACIAYLVVIWHLAVNGRAQANAKSQKVGSFFLAIAGYTLILWTAYPIVWGIADGSRKLSVDGEIIAYAVLDVLAKPVFGIWLLVAHARIPETNIDLGGFWSNGLSGEGAVRLEDDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8J8</accession>
    <name>A0A9P4U8J8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_524233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8J8"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2441290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="150" mass="16871" checksum="6E3598EB11858EE7" modified="2023-09-13" version="1">MRQRVESMVVAHVQRGETKPSRQTANPRAALRNWPVRIFPVETPCITTALLNSTAAPTHAPPADDPDRPFQISLPAFLPYRQLPRAQTPQQRAANARYARREEGKMGKPLDDRVKRTKQDFKSPIGKGWIIVLGFVLAGGAIFELLKLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9R8</accession>
    <name>A0A9P4U9R8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_73337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9R8"/>
    <dbReference type="OrthoDB" id="5238025at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="273" mass="30156" checksum="044189DF4DC2C3B6" modified="2023-09-13" version="1">MKIPEFKIPSVLGKVSAKFVKKPMFNQPVHTEKRYHVTRIIYAVLLSLLVLIAASIIGLNAVTVNFIEDNRDTGFEFVPADPNDAVILAALPRMLYTAPAKLALAAGAISIFVGATHLAFVITDWKAGKKTQAYAFRRNMMFLHFANNILILFALISSLVAHKSSSHVNVRYVSNKADRPSAADGLRYNIGTFDLETWSCEWKSIPGAEMVWSDYGAQCHVEVAGRSMMCLFLVMGTALAGLSIWGMIGRRDASGERIKTEQVELEMDKMNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9U9</accession>
    <name>A0A9P4U9U9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_66240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9U9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="55" mass="6035" checksum="F073956EC8981920" modified="2023-09-13" version="1">MLSKCIETHTCTHSDGNVPEDRRSQPESKSSDPRYGGDQLKGDPRCCAFPGIRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAR6</accession>
    <name>A0A9P4UAR6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_454558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAR6"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000051">
        <property type="entry name" value="Protein tyrosine phosphatase (Pyp1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="284"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="540"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="734"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="647"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="792"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2444799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="902" mass="99991" checksum="D3D97FB2038EC70E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAV1</accession>
    <name>A0A9P4UAV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_433940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAV1"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="328" mass="35937" checksum="00A5A94F05A29FEA" modified="2023-09-13" version="1">MPGAFQFFYGQLFTQLPKPTASFEGKTVIVTGSNIGLGKEAARHITRNNASTVILAVRSLEKGEAAKEDIETSTGKRGVIKVWQLDMSSYQSVLDFSARADKELQRLDVAVLNAGVAKGKWEVFEQDESTITVNVVSTFLLALALLPQMKRTASQYNIRPTLTIVSSEVHGWAKFPEGNAPDGQIFHELNKKPQTLDDTIMGNRYQVSKLLDVFGTRAMADRKSAQAVPVTINCVNPGLCHSSLSRDAGLGLKILKFFFARTTEFGSRTLVHAAVSGAESHGHYLSDCKVELPSEYVLSNEGYEVQNRVWDELTAKLEAIKPGVTANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB83</accession>
    <name>A0A9P4UB83_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_415614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB83"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10333">
        <property type="entry name" value="Pga1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040114170" description="Protein PBN1" evidence="2">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26005" checksum="75B6627D6CF8AB4E" modified="2023-09-13" version="1">MRTIAWLLCTLGSISTVHANVEKTIFLGPSAIVLPNVRPGIDELDVDTLEPAELPILATQLSVKFPTESAPRGLDSWYLLRGLEEGRRYEVRICWPAFQPTDFWLDTFTITQVDTPELIASLAGYTDRARTSPSQKLRYTADGSSTAQSLLFLRVQAAASYYSTNKTLMQYPPLVDVDIILEPFILNVLPRSLGPAAIYITVVAVAAWFISGYTYRWIIAVSKEYEEKDHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBT7</accession>
    <name>A0A9P4UBT7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_464198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBT7"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="201" mass="23020" checksum="CD21783C56AA4D1D" modified="2023-09-13" version="1">MSNYTKIAANSPSRSSPSEIEVAINNALEDLQNNIPDLKSSLRPLQFVSAREIEVGHGRKAIVIFVPVPLLQGWHKVQQRLTRELEKKFSDRHVLLVASRRILPRPKRSNRSRSNQTQKRPRSRTLTAVHDNILTDLVYPVEIVGKRLRTKEDGSKLLKVVLDEKERGGVDYRLDTYSEVYKRLTGKTVNFEFPQSASTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCG6</accession>
    <name>A0A9P4UCG6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCG6"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="154" mass="18290" checksum="56EB2A806D5D7078" modified="2023-09-13" version="1">MSTFSLFSRLPTELRLRIWELTVEPRTVDVSMSDSYLSSKFDNSLPVTNTPVPAPLQTCRESRRELQKHYRRGFVELRNRDDVGLRYVWVNFEIDIIYIGDGNHLGNYKAVAPQIQRLRFEAEISDEFFYRFSMKDLRRLYGWYEYLVGCSART</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDK3</accession>
    <name>A0A9P4UDK3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_265954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDK3"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="263" mass="30296" checksum="87C25A754370A4BE" modified="2023-09-13" version="1">MWTPRNHNVYRDTQSRASPSPPAKHRDSMHLAAAMVVVTKRNSTESPLFRLPGEIRNMIYDYATGHYNIYHTCEGRLIVGPIDPWDWRHAFVEFPSAPSLLALTLVCRQTYLEARLHVFANNTFDTKNFFYFRRRVDKLTTAQKNAIATITCAFDCMGKIGFNVFRLTNTIDHTENFLVKPYLDILPAFVGLKRVFVDSSKMTRRNDEYKKYAQAMEDCAVLGIWRFFHKEGMLVEFVQGPVLRLCASCGKCEHCIGNGRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDK5</accession>
    <name>A0A9P4UDK5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_355221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDK5"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="68"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="165" mass="17356" checksum="146D5AEBFF00451C" modified="2023-09-13" version="1">MADKLNSSLDDILKTTRGNARRGRGGNRRSGAGRTTEAPIGGVGKTTRQTKPNKAAPAAPAATSGGETKIMISNLPFDVEENQLKEYFNTVVNVGKPRRVLLQYGPNGKSLGSATVIFHKSEQAIKATNALQGVKIDGKPIRVELLVSAAAVAAQPTSSFADRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEB1</accession>
    <name>A0A9P4UEB1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate esterase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_430457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEB1"/>
    <dbReference type="OrthoDB" id="3915838at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040204083" evidence="3">
        <location>
            <begin position="26"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="65"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="908" mass="99205" checksum="F3BC924BFAF2FF61" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEK8</accession>
    <name>A0A9P4UEK8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_334183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEK8"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="20"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="370" mass="42166" checksum="DD01EA37673EC64C" modified="2023-09-13" version="1" fragment="single">SYRFPIQPVHQFRGASASIKRPQEVVHFSYDDDHQYKEDESGINYYCPPQLGADLKEGYNTFRHYEEETDPHVDSLLRAVMSKERKTGKKEEADFVTWRGMMTKIMTAPFDMFAEFSMFATLHDGTIYIVEDFPSRAAQRAQEATRPPPRWQDPNMPDHKMMTYWGYKFETLSLLSTPPSETPRETIDSRPRAPVSNYAQHCSIVRTGFGPHTLLLGGEVDGLSAPKPPSPSEPIPWIELKTAESLPPNPSNRDILKFERKLLKFWAQSFLLGVPKIIIGWRSKMGILTGVQELETNKIPGMVRRGTQCWDGNTCINFTAAFLGWLRSIVTEEGKMYRLRLEKKAGVVEAGEVKGAAGGIVSKEFEEWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF52</accession>
    <name>A0A9P4UF52_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_356535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF52"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="283" mass="29841" checksum="CEB393059CE2BBCD" modified="2023-09-13" version="1" fragment="single">MLLKKGEANINAKDRNGRTLLSWAAKEGCEAIVNVLLDEGADMESKDTNGLTPLSWAAKEGCEAIVNILLDKGTNLLPKDEGYNQEQLLVAAQYGHEVMVKMLLKKGEANINAKDRNGRTPLSWAAQGGHLAVVEQLLQKKADVNAAAAHTNGRTALQAAAEGGHLAVVERLLQEKAKVNAAAASNSGRTALQAAAEGGYLAVVERLLKKKADVNAAAAQENGKTALQAAAEGGHLAVVERLLQAKASINTVSYRERPALQVAAEGGHLAVVDRLLQEKANVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFR7</accession>
    <name>A0A9P4UFR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_509140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFR7"/>
    <dbReference type="OrthoDB" id="3797724at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="348" mass="38338" checksum="4E13F686C43E0948" modified="2023-09-13" version="1">MPSSQKRKQDRAKKAGRLVLPHYPLAFSTNLTLTAHVDLLNSLRDDIPESDSIPYIRQTLDVYAAVIPVFVDCLCAAAEQERILEHEPATGDKGEALGYVTAQLKTSIDHAHRIAGLVFVEAATARLHLAYSAHGDASALEKVPDGVAMLAFFEDTMRAYEGLREALATHVALCESMGEAYVSGELEDGQLLDVAGALDEVWRSRTVQLVHRTVKELFEEFAKKFFEDGQAHVEAVRVLDEYEKGFEGAWRWVEKSGEMVRRALEVAEVELKEDVGEEDVAYESDEEDGGIDTAYEGDEEDGGIADGEESTGDERDFENGETLGDERNAGGETELGEEEDALRGAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFX3</accession>
    <name>A0A9P4UFX3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_353092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFX3"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF32">
        <property type="entry name" value="AMINOTRANSFERASE GLII-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="90"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="373" mass="41222" checksum="3DBE334EC66D004E" modified="2023-09-13" version="1">MHSQVGSPQHSDVKADPGLSSRMQATLRALAPTPHDVASQAFANDSTTIDLSTAQSELIRPELLEFLKTLVEDKITEKTFAVPAGDGGDTLTRESLASFFNTSFNPIHTVKPEHIVLTAGASDALESVIHAICDEGDSIVVPGPYWFGFDRITRARQNVNIVVARPPTYQNFDNYLLPSIQAAYDFAADKSRIKAVLICNPHNPTSRCYTRKSLIECMEFCQERGLHFISDEIYALTALNDTPRNSSRFVSALSLTEPLVPEGAVKIDPSRVHVIWAASKLFGSSGFRILHITFVTPTDGIFVFARLARHAQSIEDEQDFFHRLALQGVLLGPGNVYKGVDKDFGWARIRFSIPVKVMEVALERITTFLTMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFX9</accession>
    <name>A0A9P4UFX9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_348874</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFX9"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2450514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="196" mass="21334" checksum="1225747CA7313558" modified="2023-09-13" version="1">MASVMRPGLLRQSFASPAASQRVFSTFTSSAARQSSPLIQQLRPAFARDAVPKATRIAAFHATQRQQILPPLPQKIEGSVNTAVPVPNPDYSHGSYHWSFERLLAAGLVPLTVAPFAAGTLNPLTDSILCALLVLHSHIGFESCIIDYFPEKRIPKLRVAAHWALRIATVGLGVALYSFETNDVGITELVARLWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG57</accession>
    <name>A0A9P4UG57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_145480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG57"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="209" mass="22984" checksum="055511204E619B73" modified="2023-09-13" version="1">MHHRPRRTRSGFPSGWSRTGGVVAPEKASFSGFMEVGSQVASLIARPAFAPSQSLLAKWFCVDTPFVAVAVLCHRNNDLVAGSHRSQKRTARIALPNSRQGGEGVLTASDVQFTRLPRLKLGFPYVCFEHRITCLSEVSTRPDERYEHLPRWAGRWRVSPLRAAKHPTTPSIHHLPSAPSTAKSPCTLTVSMSIASTRLDPPVASQVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGC3</accession>
    <name>A0A9P4UGC3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_428460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGC3"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="242"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="444"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2448373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="549" mass="61728" checksum="F4E3F4B7E3994919" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGS1</accession>
    <name>A0A9P4UGS1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_193683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGS1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="17434" checksum="90FF7E65C317BA30" modified="2023-09-13" version="1">MAEDWSVKNGVRSCGLPDTASVLDSVDAMWCWYAAMVPWCYGAVVLWCCGAAMWQLSARWMAWARLHAVQLVVETRFRRRANGVDLGWDHLGRPVVRWWLCCAPSKCAATAAGMPQSALPSRTRVRGHGEQRCVLPYPGEAVHESTNPRQSDGSSGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH31</accession>
    <name>A0A9P4UH31_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_187393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH31"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="323" mass="36065" checksum="A00B33EB89429505" modified="2023-09-13" version="1">MNGTNGVNHGSPQSLAQRTCAQCKSSKKKCDKVLPKCGRCVRLAIGCLYPDLEKLTDSEPGNEGNDSRFEEVFERLRRIEAQVFSPQPAAHDGTEPQRSLVELARSHGIESPNPINWTLEPGTLKPQYMSLILWQSILATLDEHKATIHGVTRVYLSQTEQWLPMISSIKFEKELALFPQLISSDSFVLLALAIHLVTSPPVDHPPAASLAESPWYRKCKYLFQYYVGFKQPNIELVQAGMLIALFEFNQDIEDRALTTLGICCRLAYLLEFDEVMMKHSSQDLGKLSADDEEVSHVSFADAGTLAHHVSCTDHTNMDGSYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH65</accession>
    <name>A0A9P4UH65_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_479417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH65"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040187496" evidence="5">
        <location>
            <begin position="18"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="504" mass="53647" checksum="0DF16D7A8A0F731D" modified="2023-09-13" version="1">MTLGYLLPLLSLPFAFAQNYTQDLEDATGYIPCDALIAVGLGDRVLTASSEEYEPRIQSWASVNARYHPWCLFQPQTTQEVSTAISTLAKTGEGAGDWHIALRSGGHGYPGSNNVVNGVTIDLGHMNNSWYDAETKVASLEPGAHWRDIYANLLAKYNVTVTGGRDGDVGVGGFLLGGGISYHTGTNGFGCDTVVNYEVVLANSTIVNANAHENADLFKALKGGGPNFGIVTRFDVEAQPAVDLAYGQIIVMEEHSDAVLKNLVAFTDKVEERPHDHMFVLYEHSPDINGSIILSVTVNTQGDMNTTSFDGARAIPAVSSSWETTSLAAAANTSQLASGRSASITLTLANSLDLLTYAATLHASLTARLTDLLGSESFFTTIVLQPMSTLYSTISARKGGSMLPPFARNSVIWVAGAGVTGDDAALAIVEGELLAVTKALEERAREEGQLEQLVYINYAHPGQDGLGSYGKDTVAFMKGVAKGVDPEGFWQERVPGGFKVGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI13</accession>
    <name>A0A9P4UI13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen permease regulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_460310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UI13"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="557" mass="60990" checksum="405DF3F97E0E6A6F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIT1</accession>
    <name>A0A9P4UIT1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_438689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIT1"/>
    <dbReference type="OrthoDB" id="3800709at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2452061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="270" mass="31149" checksum="BC35AA8DE8396986" modified="2023-09-13" version="1">MSFTGRNNMRLGGFAIIDVQGVEEMIVDRDDEGFLAQGPGPSASTPVVGLHQQQQQQIANEMQLPRGMQQSAVREEQGQDLPSRQQFMDPDNAQGLLALSDPRTDAHTDDDCGICNSNMRDLDEAVVIVRCGHIYHRSCLLPWFDIDVRVHTCPYCRKDLFTAPIQPTHVTTVPTIPRRPTSVIAAWRILINVQRNYWRQNIQRYVEARDQRTYYNEDLLRRLGFTENRMSLSDAEILLRIEDEISRLNERLERIDEQESRLQLEDEEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJB0</accession>
    <name>A0A9P4UJB0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_480182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJB0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040241357" evidence="1">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="68" mass="7265" checksum="04855C4551E89DAF" modified="2023-09-13" version="1">MKLNSIIATFAQAILVSASQSSKDPKPPRTPTYTPYTYTTSLCTPTATQPYTFTNTCTGLATTSILVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJF2</accession>
    <name>A0A9P4UJF2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_450459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJF2"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="554" mass="62073" checksum="21D46932F15C994E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P2Y8</accession>
    <name>A0A9P4P2Y8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WLM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_181101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P2Y8"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2437349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="456" mass="50649" checksum="A5488832FFE158B4" modified="2023-09-13" version="1">MREIDAHFDAYEHLKHLPRDGEALQMLRKAASMVKPMMRKRGWKVATLAEFLPDEPQLLGLNINRTERILIRLRYHHDSRQFLPMEQIADTLLHELSHIIWGPHDHNFHNLWNELRDEHQSLLSKGYTGESFLSQGRTLGGKRIPLDEMRRQARISAEKRKATKNQNASGRRLGGGMSSHGVDMRKVIADAATRRTSITEGCASGSSEAGRLRDQQAQTGFRTKADENDANDLAIAQALQELMEEEEMIKLEELCAPNGGGGLAWDPVNGLQFDTEPPSSRTTTPKPTPSRSVSSNIAGRPLSRLVAENTARRPTSLPSFRRPSSRLISQEEEAIRNRSLPSSPPEPSPASFVAPADPGKWACPQCTLHNPLDFLACGACGLEQPPQPIPQNQRYGSSHHLASLPKPPPAAGLRGASATPFEPAKGRIGWNCLNCGRFMEHQWWTCSLCGKMKDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P434</accession>
    <name>A0A9P4P434_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_505743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P434"/>
    <dbReference type="OrthoDB" id="2787676at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="118" mass="12766" checksum="A73FFEBEDE21D65E" modified="2023-09-13" version="1">MGMKALKSVGRALGDSGAWKKLANPTVSRGKTAWPKSNAELENIGVRFDYDEEVTQNGVVYHKFQCQPNAGKISASLKAWREKHGGTHAVMTTILVRKNATKSEVLQAVDGALNNVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4L9</accession>
    <name>A0A9P4P4L9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_492322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4L9"/>
    <dbReference type="OrthoDB" id="3780976at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="1">
        <location>
            <begin position="179"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="359" mass="40178" checksum="8CBB9069F257628C" modified="2023-09-13" version="1">MSFQELFKKSLSLCLIVPIFVTMLVFPQMPLAHSTPTNELWPRFRLNSAQDSYPPPQIEFVDFFGCSPNQRAMIMQDRFDAQALALSSLEAVNSTLAAASPDPASYVKAGGTFTIDWTTSAAREHWGRLSWASNAEADRSRILTTLWKATGTYPIASPHQPSWMRRVSIGCTGKIPLEDIQACEEAIAFTYLLDTPVITFCPDYFTFLSLTEVDAALERYPTLRCSVKVFDLSRAWVLLHESLHIKGSPAQQCVNPIVRNQGCYDYAYGSGKAKLLAGVNPIKASANSDTYGSFAAARYLERCYGRYPKYPEVWSAGKTDEENARHARQEPGFVAQIMIEEVRAKLAKPKLAKHKQWII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4P9</accession>
    <name>A0A9P4P4P9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_492307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4P9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="161" mass="18461" checksum="9D6C4B27267E948D" modified="2023-09-13" version="1">MSTRSNRCPAATAQHRLLTSENAKRLRRPVSQLAILSQIDSSTNRRSLEFGKWNVRSRHNYMADWAGQQEGALMRTALKLTPLSSDWLPYLDPPDFLHQRPKRKQAIHLKNTSRLTTPTRSMLETARSYHSTLWVAKNGGTGGTLCDEEMKEEYIYMRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5T0</accession>
    <name>A0A9P4P5T0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Benzoquinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_492143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5T0"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2437398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="204" mass="21945" checksum="5F9306A79EFF752D" modified="2023-09-13" version="1">MGPRIAIAYYSMYGHIRQLAEAEKRGIEEAGGSVTLFQVEETLSEEVLAKMYAPPKPTDIEVLSDPAQLEPFDAFLLGIPTRYGNFPAQWKVFWDKSGKQWSLGSYSGKYAGVFVSTGGQGGGQESTVIASMSTLAHHGIIFVPFGYKHAFAQLSDLTEIHGGSAWGAGTFAGGDGSRQPSAKELEIATIQGRAFYETVAKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5W8</accession>
    <name>A0A9P4P5W8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epidermal growth factor receptor-like transmembrane-juxtamembrane segment domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_502090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5W8"/>
    <dbReference type="OrthoDB" id="4157427at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049328">
        <property type="entry name" value="TM_ErbB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21314">
        <property type="entry name" value="TM_ErbB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040265758" description="Epidermal growth factor receptor-like transmembrane-juxtamembrane segment domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Epidermal growth factor receptor-like transmembrane-juxtamembrane segment" evidence="7">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="232" mass="25168" checksum="4C987A9EAF80C5A1" modified="2023-09-13" version="1">MASLKSLFGGALCLLLYTTFASNIATFEDQKCKESKENMNGPNGYPNGTCMPLDKKGSYKSFQIVGLDGGCSVTLYGKDSDPGSPCSSETQLEFPRIGTCYNASWLYYSIDSVTRLTHCHHPTHYATPTATENTFAESPHKKNTGAIAGGVVGGVVGLVLVAASVFFSVKRNRRLQQEARKPVSATAPNELPTQDVKYKIYSHEASLPPQEMGRNSVYISPSELHNDTSKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6D0</accession>
    <name>A0A9P4P6D0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_422826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6D0"/>
    <dbReference type="OrthoDB" id="4152607at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="272"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="580" mass="65781" checksum="11AF155718AC9931" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6R5</accession>
    <name>A0A9P4P6R5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_505587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6R5"/>
    <dbReference type="OrthoDB" id="3783962at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040360203" evidence="1">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="256" mass="26936" checksum="32AD05E0ED790983" modified="2023-09-13" version="1">MVHPRVLLVSNLIHLTTAQLPTSKATPVDTQPFRHPIHGDVLLPGSVFTIEWEANPAFHNVTLQLWDKTSWGFARDLLAPCHPWARNPFCGTIAASAPNTGAFAWLVPDPRNGSLAAGFPRGERAYWVKMYVDDYLQPAVGNADPVLSYSRNFAFAREGEAARLVTGAPTVTSGEGEGEGDGGPPTVFVTVVGNGTASVTGDGEVVETGTGTVGMEATGEGEGSRGNKTAFAPVEGRAARVEWSLMGGVGLLLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6W3</accession>
    <name>A0A9P4P6W3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1168-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_318245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6W3"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="100" mass="10962" checksum="7CD145B33E06A862" modified="2023-09-13" version="1" fragment="single">MSENIPESIPTSADPRSKRPTKKRALTPGGKLAADVEALFAKPDREIHIPGSKFDKSLAPPPEIVANVQGSSAGAGSGEFHVYKASRRREYERLRMMDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P736</accession>
    <name>A0A9P4P736_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_423673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P736"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44068" checksum="8612B3E3BB766A6C" modified="2023-09-13" version="1">MEEIELCKEITLDRRPDVIKFWPHDDQYAVVGTYTLLDDESAETEVPTSQQRVGSLNLIHVTDDKIAIIQTLPTPFGVYDLHFAPGKEIQAGKEDPGSFAVASSTGSVALYRLIPSEEDDASSLHPKIRHMYTIQYFSKDILITSLDWRRHDLVAMTLSSGQVCLGKVRDPSVDPIISVELMQHDFQAWHCSFVESENGSETGLGLISGGDDATLRYTPVETDQISALGFVDEDSTPNSLPTTSWVDRKIHQAGVTAVMLIGSTSTGHLVITGSYDDHIRLLHIPNVGRREVLAEEYLEGGVFRIKLVAKCGQDNSGSSETQQSYALIVSCMQAGARIVNLHKTGEEWRFDVKAKFEKNAGTLLYASDCQSAGADGRRTIVSTSFEDRKLYLWKAIVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7Q5</accession>
    <name>A0A9P4P7Q5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_467594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7Q5"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="472" mass="53505" checksum="A548838D7CA48764" modified="2023-09-13" version="1">MRDGFQFVGRIPYPITEPKHLVVASEVATMDFLRSQGIPVPQIYSYSATSENAAGTEYMFMERTQGTNLGDIWFDLSEKARITVVTKLVELESRLFALAFPASGSLYYTKDLQTGIRKVKVAVANSALNNDFCIGPDTRLDLWYGKRGDIEIDRGPYSAGALTAGAKKENAYLTKFGQPLHPFQRLRREIYNYQKQSPLDHLDSLAKYLRVAPYLIPHNNETLNRPTLRHPDLQPNNVFVSDELEITGLIDWQHCAILPLFAQCGIPNSLQNYGDSVSESLATPELPAHFDELDDRSQFEQVLLLRRRQLHYFYVATTAKLNPTHYDALTYNFSMLRRKLFDHASCPWEGDNVTLKADLISLSENWSSIAAPEPGASGDTRTLCPISFTEDEVTECKRLNAAQIEADEQLQACRDVIGIGPEGWVPLEYYEETKQRALKLKADALEAAESEEERVRLGEHWIFDDFDEEVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8G0</accession>
    <name>A0A9P4P8G0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="11">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BNA4</name>
        <name evidence="14" type="ORF">P171DRAFT_458427</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="11"/>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8G0"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="4"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2438778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="486" mass="54666" checksum="5C3B530451F17697" modified="2023-09-13" version="1">MAEKVVVVGAGPVGSLAALYAAARGHDVEIYELRPDLRDPTTTALNFNKSINLALSERGINALKHTGLPDLADAVLGETFPMHGRMIHLEKKGEYLRIPQLYDPRGKSLLALDRAELNKALLDHLESMPNVKFFFNHKLLSVDFKKQLAWFDKHNKSEAPEERGTEIEIKFDFMIGADGAHSAVRYHLMKFVPMSYQQEYIDKLWCQFHIPPAPSGDFRLPPNYLHIWPHDDSMFIALPNLDKTFTATLFHTRTGFEDLDASGKVADYFHTHYPSVVPDLITATDLQKQYTDNAHLSLVSIKCTPYHYTTTGVILGDAAHAMVPFYGQGMNAGLEDVYALFTLLDRYPSDRATALAQYSATRTPDAHTINDLALGNYREMATDVKSRVYLLRKWAEEKLDLWVPALGWATQYSRVTFSNMRYSEVQRRAHWQATVFNGVLGGALAAAVGATLWWSRAGGVQRVKMGVLRSICRVAQWIAGPPQTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8Q1</accession>
    <name>A0A9P4P8Q1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cutinase</fullName>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_435283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8Q1"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="104"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="235"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="273" mass="26690" checksum="8BD2C709163F4085" modified="2023-09-13" version="1">MPSFSMPSFSMPSLPAGLSLPTGDLGSWGSGSGSTLPSFGSLPGGTGAIPSVPSTATPTIVAAQPTSTGSTGGSGTVGSNCTPQAASGGGLGGTENGVTDKNCCTGLTVIFARGTSEMGNVGTISGPPMFKSLRSKLGDGKVTIQGVTYPADAAGNANMGASGGPEMAKLVKAAKSQCPGSKIFVSGYSQGAMVVHNAFQQGISASDVTGAIMFGDPLKTMSISGLSTDKVKEFCATADSICGTGTNPTGSHLSYGNVADEAANWVIKAAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9P2</accession>
    <name>A0A9P4P9P2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_435745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9P2"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="16"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2439907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="355" mass="37655" checksum="FABE2ED4B688951B" modified="2023-09-13" version="1">MSVPQTHRAAFLHGKGEAPKIAERSLGKLKPNEIAIKVAATAINPVDWKLRDYGLFIVPGWDYPAILGSDGSGTVAAVGDDVSDFSVGERVFFQSGYGDADVSTFQDYIKLPAEIVAKTPKNISDEEAAGIVLATHASATAFYDKTGHGLKAPWTEGGSEVGKGKAVVILGGSSSVGQYAIQLARLSGFERIVTNASAAHHEYLKELGAHVVLDRNASTAQDFQKAVDGLPLEFVFDSIAIKQTQLLGVETLQATGTKDSSVVIVGMVDEEAKKLGESKEPNVAVKQILGIALAPHLRYLITALTDNLGGEKGWIASGKFKPNRVEITEGGLEKLQEGLEKNKTGVSGVKVVVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9W1</accession>
    <name>A0A9P4P9W1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_368519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9W1"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="156"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="235"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="356"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2440012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="449" mass="51077" checksum="3C2EBDC06B434739" modified="2023-09-13" version="1">MGVGAFMEPLVVVTLLFGGTWVNRNTTYRVFDRRRDHANSRSTSPDGSAESGRSSPRSSASLLDGYRASSPSLLAEQVPYWRKREVRVLGFRKEVVSPNTRRFEGYFLSRLLQKFPFLVEAWYWALIYWVYQLGRAFTALTLVDETVDVARQHALTLIHIEQRFHIFHELDVQHWFLQHPFILHWTNRIYSFIHIPGTILFLVWLFYYTTTRNRLDLPLPNKPLGEADGSPAGPRLFAARRRTMAVCNLIAFVVFTLWPCMPPRLLSDPNVSGDVGEEARAFGFVDTVHGTKGESSVWTQNKFCNQYAAMPSLHFGYALLIGLTICSIPLAPQHHRARSFPLPLLRVRVRMPAPRRLACLAIGIAYPTIILVAIVATANHFILDAVAGACVCGLAWTGNRVLLNLLPVEDYFLWCVRIHKPERRTVLLDGEEEERWGSETVRGKGALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAR9</accession>
    <name>A0A9P4PAR9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_125938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAR9"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="132" mass="15771" checksum="E96368CACBEFC10E" modified="2023-09-13" version="1">MSPTSQRNVTPKHLQLCITRHRRYTQTRYTSHSLNMDSDKTLHDLLRKQYTELVGRWKRLLSLRQISQIRFVKFRLHTNKLVTIETHSEMEARIRESLPQENDEDYKYAPPEPVFLPPIGHNETMHYSTSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAT9</accession>
    <name>A0A9P4PAT9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_369717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAT9"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000094">
        <property type="entry name" value="Probable ubiquitin-conjugating enzyme E2 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057733">
        <property type="entry name" value="UBE2O-like_SH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057735">
        <property type="entry name" value="UBE2O-like_tSH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23043">
        <property type="entry name" value="SH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23046">
        <property type="entry name" value="tSH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="709"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2439616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="955" mass="106974" checksum="219720C5E647D71C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAU3</accession>
    <name>A0A9P4PAU3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_393002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAU3"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="75"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2441610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="297" mass="33280" checksum="23694ABC0F563491" modified="2023-09-13" version="1">MAFFLTPRFAPAYTAQQCNPWACAPRPQQSYRRVARPSFPSFAPFLSEMDEIISALDQEAQREAARREAHRQRQQRKRIVRAHFNVHEHHGGYQVDAEIPGFEQEHLEIEVTDDNTLRLSGNTERKAESQPQSTETPAIEAEAHNEVVGGATLNEPEETTASGAATPTHSDTDSLKSYQATVEDDFEDLGAETSSTISAHTDSEPPKEPKGKEKAVEEPPTTNTETAVQQQPQPETPAQQQQQEEQEEWRFHGSFERTFRFPERIDAANVTASLRNGLLSITVPKAKAPEAKRILIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAV3</accession>
    <name>A0A9P4PAV3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_103962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAV3"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="38"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2440595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="565" mass="61579" checksum="12CB10F0A0421744" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAW2</accession>
    <name>A0A9P4PAW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_500009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAW2"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="132" mass="14372" checksum="560C2E12DD7D7BE2" modified="2023-09-13" version="1">MGRLWANLQTVVCRDATTPPREGGDAKEKIAIVLVSHAGIVRNGDASFKVVHHLSTMGHKSYSGAHARFTDLRVPQANTLYGPGPQAVESVRSSFDNTGVLVGAMALRGRWLMPRWRSQKCIAAGAHRHFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB35</accession>
    <name>A0A9P4PB35_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_435630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB35"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="197" mass="23869" checksum="40FC6167F7A0971D" modified="2023-09-13" version="1">MAPCLREVRLARRGDGPQDRLRYINWEKLREKLPRRMRYPRKTDFHYHEGYIDYRLLSLEEVIEKFELTKMLELRRLEEIVLEYDGYVCWYARGDGDVLAAWGELADNYYFIKLLGKVGSWLGDKLKRQNVQDVEVFADMESPRVRDEFERQNWQEAVVYNQIQVPDVWRWSHCVLRECVDFAHFQRAEYLVVKQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBD8</accession>
    <name>A0A9P4PBD8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_85640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBD8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="242" mass="26828" checksum="8909A22E5193A84C" modified="2023-09-13" version="1">MGRHLHCSYPHRGSPEAFNIYTATSLIRKAPKPTSSILATPIEYVLTVLPLYSYLLSQFMICAMFSFLVDVLVSVYPTTRVPFFSLEALPNSPHGILLSIVRLRAYASHGKTHTFFLKYCISWNLGISSQCTSVSGSIMVRSSVRDANTCYLLIAHVHPCIPVKQPNATGAWPYPDLFDHVLDQTSLLNRIGRFFAVPAVATTCLRRTKAIPNFIRSRHVQGMLLSSGWVLAASRTNAALPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBR1</accession>
    <name>A0A9P4PBR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_419180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBR1"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000017">
        <property type="entry name" value="Oxidoreductase family NAD-binding Rossmann fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF11">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="136"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="353" mass="39202" checksum="43EC92BCA92EAA40" modified="2023-09-13" version="1">MAPRKLQIAAAGLGRMGHRHALNFLNRTPRAQLVAAFSPDPKEHEWAREHLEGVALYTDYDEMLKIEGLDAVVIGTATSVHAEEAIKAMQKNLHVLCEKPLSTSVDVCRQVVEEAKKRPHLKVMCGFSRRFDDSYQNAYGKVEQGQIGRPTILRSQTCDKHDPSGFFVEYAAWSGGVFVDMSVHDIDLTLWFFGKQIVPKSISAHGCIAVQPGLAQHKDVDNAVGIVEFWGGQIAYYYCSRMMAHGQEDVTEVIGTEGKLSVNLNPQNNLVQTYSGNGITREVPAHYYGRFEMAFVKEANDFAAACLDDTSLPMPIENAVKAVQIGSWLQEALVSGKQIHFDQNGKRLEKPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBT3</accession>
    <name>A0A9P4PBT3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_524543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBT3"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF14">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY PROTEIN 7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="266" mass="28564" checksum="E3CB8AE4EAA904B5" modified="2023-09-13" version="1">MKDIASKAVLITGGGTGIGLALALQLAAEGANIIISSTSKERLAAGAQQIREASPNVKVLDIVCDVSDRNSVKQLKDEITKAGLQVDILVCNAGVTTSGDYHLHREEDWDWVYGVVLNGTTYCIQAFYPDMVTRGSGHIVINGSQAGMVPNWVTLHGPYTSAKAAVHALGAAMRPEAATHGVGVTTVVIAGTQTEIMKSERSRPDRFGEPLKVEVERRAARRIPSSDVAGKIVTGIKEDRGWVATHPDLKDRTKQYFDEILAAYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC53</accession>
    <name>A0A9P4PC53_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_465902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC53"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF68">
        <property type="entry name" value="CARNITINYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2440306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="283" mass="30308" checksum="C689FF0032B0883E" modified="2023-09-13" version="1">MASTILKPATQPPPTSHVLLTYPAPYVLLVTINRERQMNSIPFAGHTEMGQIFDWFDREPNLRVAIITGAGKKAFCAGQDLIELGKIRQGTVEKDVAKQRHPLSGFGGVSRRAGKKPIIAAVNGFALGGGFEIVLGCDMVVASPTATFGLPEALRGIFAGAGGPPRLVRNVGLPIASEMALTGRPITAQRAKELNLVNRISPSPDTVVDEALKLANDIAAISPDAAIVTRAALKEAWEQGSVERATQLVIERFDRDLTTGENALEGLKAFAEKRKPEWKASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC83</accession>
    <name>A0A9P4PC83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_457139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC83"/>
    <dbReference type="OrthoDB" id="5390017at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="214" mass="22895" checksum="B9D80C5222A5FA5D" modified="2023-09-13" version="1">MDAPISRKRSRLALDDGEDADDALKRSRTQSEIEELAVIPPDEAWTVDVAGILASNTLAPPPGNHLRPHSNADWHRSGSLFVLCVQGSVQLHYDLLCSVLPQLYSVSPSLQALVLCRDPSTHVPSAAAAAFSLPLVQAVGPGYNHFVRLGLLHPLGGGEHPLDALVVVDGRARRRLVLPFGWGAGKHVGTPAGRIVQAHLMNLLASCVETLARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD88</accession>
    <name>A0A9P4PD88_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SPX-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_79656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD88"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="665"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="721"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2441812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="845" mass="93999" checksum="77A9CEA5840887E0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDU6</accession>
    <name>A0A9P4PDU6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_90589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDU6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="210" mass="23036" checksum="80B63ABDC3CB4655" modified="2023-09-13" version="1">MHTPPARMQVSCKVVLGPLASGRRASKRSQLRIASGVSMAKLVNNLSASQSRRRAEKCFAHRERRLEVRPGAQGHRRARRTVRRPVAWSRPRAAAGMRVANHGSLGEPTRQSAPPAGIECGSRGAREAFLDSAVDAEAGWHWTPIRCVTDWFERRPETRPRSHGMSPVACRSSSRRQTTKTAASRGDDGVKLSQSRARRGAGGRCDGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDY4</accession>
    <name>A0A9P4PDY4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_416795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDY4"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="42"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="321" mass="35685" checksum="62B6F2E99E582261" modified="2023-09-13" version="1">MWGVIPPPPGVPPSFGERTKLQERSITVYTALTAVATFFVLLRLYTRLYLTNNLGWDDALVFLGWIGCTAWIAICMSALQYGFGQHIWNVTPAQFAVYLKLLTGISIVYVWTPALSKLSLLALYYRILPDKPSRAGVHILFVVILGYNLGVTITIVGPCNLLKHSDPTCLMDTNLAMAILNIITDVCIIVLPAQILLKLQMDRKQKWLIGITFVVGSGVIIISIVRIIYVYKYVGDPDVTYYQAAAALFSTAELNVGVICTSMIGLKPFVDTCRSFIHTCWAFIKDSQNSEHSLLTKDEPIDLEVYYVVGHNKEDSGLGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDZ7</accession>
    <name>A0A9P4PDZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDZ7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="158" mass="17229" checksum="F732304EB01717A8" modified="2023-09-13" version="1">MKRRKVTVSLEDTLTSFTLNNILVTSFPSLSRVAKHPVQTRQKEAPHRTSDTKTVSGPSGGKYTPYQTFNCTPYQAALSSINPRGVPPIKAHIFSSWSPAFQPTASTPSFLNPSPKSRIQAYLRTQPSPTQELSGRPNNRPCSKYSTSSSSSQSASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE78</accession>
    <name>A0A9P4PE78_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_435003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE78"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040377155" evidence="2">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="91" mass="8714" checksum="06DE3C635C758A87" modified="2023-09-13" version="1">MRFPNVGLHFTLSSLAVAQNVGLGSLPQCGVSALRLVWGSYSATTPPATTSASESQSVAAQTSTGSPGAAGSVATAGAGLGLAVGVLLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF61</accession>
    <name>A0A9P4PF61_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF61"/>
    <dbReference type="OrthoDB" id="3797170at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="307" mass="34414" checksum="4B0C7F4C57C4E0AF" modified="2023-09-13" version="1">MFLGRDRSTESASPPPDEILDEGGGPPFPFYIPTPEETPAQEEIEMDCTPDCTLNIDYLTLLLRPPSASSAGSDLSWTPTPQTIVDDASKDSQDGLPTEADKDLNVDDATDVEDKIVSVPFSYEDGDGVRRECRVDVGGAELLAGQKQGYAYVGTEHEETEEEVIAREEKAKKIGWMEGWLARLNPAKHQVKPKKWVRDGKGGGCWVAVDNDKSLRVVVEWKKARLEEGRWFVESDVVEREDMRLEKLSSPPLRYKLEVTRPRARHVPGGEENMDPLTRRASRFQPPLVGRFSVEQEMLLMGKTDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFC1</accession>
    <name>A0A9P4PFC1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_416500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFC1"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="954" mass="108614" checksum="79AF6C085AF01235" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFZ7</accession>
    <name>A0A9P4PFZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_464786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFZ7"/>
    <dbReference type="OrthoDB" id="3489571at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040350711" evidence="1">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="104" mass="10743" checksum="D529C8F4575D6225" modified="2023-09-13" version="1">MHFTSNVIFATTLLAPLVAADLHWSGLCVDTIGGQTVYNDAATKAACAAYAGRNTGSKQWDTCPDCVMQTVGGLPSCNSPAKHIGGDELNYYCKQNGAGGATAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG76</accession>
    <name>A0A9P4PG76_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_444659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG76"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040145195" description="Alpha/beta-hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="87"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="415"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2444489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="56716" checksum="27A7B5529CBD5832" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIA2</accession>
    <name>A0A9P4PIA2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_430968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIA2"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="2">
        <location>
            <begin position="121"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="234" mass="24918" checksum="67222609CC303C12" modified="2023-09-13" version="1">MAETKRQSIAGKIATPKVGPSKDAIDNDSMLYKAVGARIKITCAPHNNVLEGTLFTTCNVTNAIAINTAPAPPNPSAPLASQPGDYHIIPFAHILSFELIGAGERVPASAAGFDGTLPSIQKVDLAAIRAREEQTIREMKKKDAQKGKGVSKEAQDIFDAVSRLLPTRWADAQIVVNDAVLINPPYTVDNLAAPSGKEQSVAQVRKILENHYQRKKNAGSRAPVATPIAPRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIC8</accession>
    <name>A0A9P4PIC8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-dependent isoamyl alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_431409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIC8"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040369791" evidence="6">
        <location>
            <begin position="19"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="123"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="585" mass="63978" checksum="54F8FE6A12DC7471" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIV6</accession>
    <name>A0A9P4PIV6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_42444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIV6"/>
    <dbReference type="OrthoDB" id="3797007at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="413" mass="45881" checksum="DB8056D3CC5C4B56" modified="2023-09-13" version="1">MSDMNINFGTTHNGPSEMMDIDPPDMATHQPEDAQKASQEIAHELVDSVMGTPAPDGAAHTPSTPQVLDTTLDLDETTESLVPPQDLQSNEDPQYTEITHIPSIQKLFASYAKSFPASSEIGPKGFNYAKYFDPVRMTKVRAKHGSRLEKAKALAVALLEHYYPEGQGYRVEPAEFPLLQLGGWRTWIYPEDCYDAAEGKTDTIKAALKKNAKPVYDTFAGNIFADKFHQILPEHIAGYVVLSEVQYADGSTHWAQHTYLAIMMDDLDTFQHWVPEKLMRTTEEFVSMPRADILNDAMGRQAGVSSGYAILMLGPRFEFYNYQANPAWEEKSWEHNLGPDPEEADYDPDSAAEEGTSSFSHLGGGDVDSTAWVVDIRSKRSTESLAAVDTLFKSVVGRDVEYRDGYALPGPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ46</accession>
    <name>A0A9P4PJ46_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_287293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ46"/>
    <dbReference type="OrthoDB" id="3792554at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="431" mass="48374" checksum="B5BEA0CC6431F93A" modified="2023-09-13" version="1">MPSTLESLHSALNARSIPCTLTGELSSIMSFTNAPLSYTLRIAGSKTSTTVLVIKSQEFTSNAFRVINEDYLAELCVWVSNFQSEKEREAASGQMRLVPRTDSALLGILQKDIETSNLLEPFAPAHTMVEWGHLLDAVVTLFAPFGLQPDFSAPDSVSFGVKELITNGYCAGPKIFRLKKYGFEGEIRGGLNLSTCVTLLYARNLGPAHADADRNRMLSRMLVEAEYVGELAEDDFMPLKVLLYDLAKADDRRALVERVLLIRDLEREGQPSFEKSKWMGKQKRYYMRIDFTPDEKSRPAARAYHLRKEAGKGSRLREDITDEDINFGAKERVVERSPRPPTGGENPIEVALWKELERFNESRGLMMEQTLKRERDGGVVPELTREEDEETVGPVTPPASPFTHAFNMVEEDEDEDGGIRLHPDTLPELGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJE8</accession>
    <name>A0A9P4PJE8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_29680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJE8"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="66"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2444273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="383" mass="42236" checksum="C407273B0F350525" modified="2023-09-13" version="1">MASSTAKLPWYPIPASRNGTTCNVHLLQAGGLMIPYDRVFLPGPKQNSHTLSPNYDPSKSEKYYVPDYCFLIEHPPTGNHYIFDLGMRKDLESLPPLIKRDTLPVFTPFPKSPADILKKHGRPEQQPEKVKAVLFSHVHFDHVGDGAKAGFTNAELWVGPTTCTYARPGYPDYEGAPVLSENFPTDGSRKIVEAYVSDERLGKNRDSRVGKVARGKDEGKYEAVELRDVGDEGWIGLGSFECAFDVFGDGSAYVVDAPGHSPGHQMLLVRVTASAHSGSSASSSDEDSFVLLAGDCYHHPDLLKDPERTARPPYSKGSMHADPEVAVETIHRTQSFAHRDNVWVMAAHDFSVGEALRKGEKVVEGLILMNDWRGKGWKPDAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJJ0</accession>
    <name>A0A9P4PJJ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High affinity glucose transporter RGT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_360519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJJ0"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF61">
        <property type="entry name" value="HIGH AFFINITY GLUCOSE TRANSPORTER RGT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2444089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="558" mass="60378" checksum="EAB6D838E905F214" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJK7</accession>
    <name>A0A9P4PJK7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJK7"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053144">
        <property type="entry name" value="Acetyltransferase_Butenolide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="226" mass="25067" checksum="E806921BE27B8EAC" modified="2023-09-13" version="1">MTSATVGFGLVPELACNVVRFKVFKCNNNASVEFVNMTTTKQKLTHRTWTKDGYFISTDPALIPIAELNTVFASDLFYWADALPEDVMRETLENSLCFGMYESPPAAPATSSTGPSETIQPKLIGFARCITDFTTFLYLTDVYVDPKMQGKGLGAWLIKCVQEVIEAMPHLRRSMLFTSSWEKSVPFYEKLMGMSVLECKRPAEGEKGGGVAVMQMKGPAFPDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJS6</accession>
    <name>A0A9P4PJS6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multidrug resistance-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_387056</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF404">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="899"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="941"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1124"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1153"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="274"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="611"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="898"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1222"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2444598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1463" mass="160997" checksum="8644690C88218DBE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK53</accession>
    <name>A0A9P4PK53_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_521688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK53"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="138" mass="16042" checksum="FF86415096A4A928" modified="2023-09-13" version="1">MSQPTIVKHYTRILALWPKDLLRPNLPFTRTIERRATPYGVKPVSPPIEEAEKSDKAAFAKPAPVVKSSPQAELPQINALFSLLENRYSKKYPLSPGVFKPTSNPEHYDRLMEEIERAPKKSWLQAKMDEWKMKIRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK61</accession>
    <name>A0A9P4PK61_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_464027</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK61"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2444419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="119" mass="13823" checksum="840950C3C3653333" modified="2023-09-13" version="1">MPQDMPPSGGYGPVQYKRNLPARGFRPAMYLAGTAALMTYGFWRVGQGIREHNELAREKMWARIYLIPALQAEEDRDQVRRYLADKAREKELLGTETKVYNSDRFVRPTYAVTPEERLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKU6</accession>
    <name>A0A9P4PKU6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_471369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKU6"/>
    <dbReference type="OrthoDB" id="4738527at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57666" checksum="FCD69711C6D76A77" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKU9</accession>
    <name>A0A9P4PKU9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein-like II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_273403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKU9"/>
    <dbReference type="OrthoDB" id="5194099at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF42">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="1">
        <location>
            <begin position="83"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="340" mass="36893" checksum="90976E839DD15A47" modified="2023-09-13" version="1">MQKPNKSHKHCEYTITNSDPIPHLNHPSNMYLPHLLPFTLLPSISALKIATSLQWIEHTPQAYAIKNFYKGSSTATLSSGGVANLASDSSIDLAANAETQGLKQYANHKSLRLIYIITEVSYRLVARADAGVKSLSDLKGKKIGSMPGTSAAVFVQRMLASAGVSDTAYSIVSGNVCMKAPCGSGTLPGMLAGKQVDAFGIWEPAVELGIRAIGANNAAVFQNGTVYREVYSLYTTTDKLSDPKKRADIVAFVSALNQTLEVYNHPNASVYSFVADRVGMDAEVVKAVWEDHKWSGTWKDAELMPLLVDEDVMLAKSDRRAPISRADLEKFLDKSVIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKZ1</accession>
    <name>A0A9P4PKZ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKZ1"/>
    <dbReference type="OrthoDB" id="3763763at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="40025" checksum="FBC97BF743517ABC" modified="2023-09-13" version="1">MAASNESFSHDGETFAMDIHRRDQTKDLTSDHTDIPSDISATDREREPKGLFKLPAELRNKVYKYVLTSDNPLSCIVSPGINTNRKPKIIPSQSNIRRIELRTAAARPSFNQLQFVNRQLHHETASLELKFNPIRFPLNVVGRRTDTTPMQSLLALRAAYSPAKFSWLSDVRLRSLDALAQWKLEPWRSSYGVLPVAEFCKEHPHINVQYMLDAFATWRDGEQRILIGHFFQMGAALMLALKNDRSALIECLPDAGALIIKDAMWVEKTVHFLLFKGHDTSSVSDRLDEVFSGIGNLRIFPSVERVDKEAFADYRYGTYMTPVSDFTELQQENWLKWALSWIKDGIKPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL42</accession>
    <name>A0A9P4PL42_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_254122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL42"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="393" mass="43851" checksum="9CE8738B2F3213E8" modified="2023-09-13" version="1">MVTLKPQSKTSHAFESFRLKSSDDHFSTFALESRIKTQARPGALAGTCIVVKDNIDFKGMKNSVGNKAFYDVCPPRNESATCIQPLNEKGVVVVDKAKMSSFANWEEPIESTDYQAPWNPREDGYQSPGGSSSGSAAAAATYDWLDIAIGTDTWGSVTRPALWCGCYGLRPSFGAVASGIEPCCQVYDTAGILGRDLHKCRDFAVEWLSPAALQSPPMSFASIIWPIDFWKPTDAKQNAIAQAFAQQMKTFLNAEYAEVSFEATWLASPPAQAASKPLPEYINEACDMQEYDAYHNLDDFRENYHRQYNHAPYVSPPNQKSWKFTKTISKEARNKGFARLDVYKKWFEDAILAANNNNNTLIIMPQESMQSRYRDELPTYASPIHPRASTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL85</accession>
    <name>A0A9P4PL85_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_410346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="121"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="8">
        <location>
            <begin position="854"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="7">
        <location>
            <begin position="1221"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1126"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1534"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1185"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1550"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1581"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1604"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1616"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1756"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1794"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1848"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1863"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1918"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2016"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2047"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2109"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2159"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2186"/>
            <end position="2195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="2214"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2236"/>
            <end position="2319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2446251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="2319" mass="260228" checksum="250520F6A14AD93C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM53</accession>
    <name>A0A9P4PM53_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase-like protein SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_430706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM53"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="231" mass="25193" checksum="E117A31D9D5DB770" modified="2023-09-13" version="1">MTPTRTIVTFGAGPGIGNHISAEFASHGFNHVILLARNEQRLSTEDTAFVSKTNPNVKVDTLRLDLANTSSIPTTLQKIDDLTHGEDLEVVFFNAARIKPSGVLDVSVQEIEEDFKTTNVALYTIAQWALPRLQNLKKTNPASKPSLLVTSSFLPREPVPQLLSLSLVKASQRNMVHSFNLTFQESGVHVGLINAGGVVAPENKNLNPKNIAEKAYAFYESGEGLDVDINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN57</accession>
    <name>A0A9P4PN57_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_409535</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN57"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000800">
        <property type="entry name" value="ATP-binding cassette sub-family D member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="122"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="464"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2447120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="81007" checksum="0683F38678E0E517" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNK6</accession>
    <name>A0A9P4PNK6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNK6"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040344481" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="212" mass="23798" checksum="C360B83291120313" modified="2023-09-13" version="1">MVLGILTAIAACPAIIGTTEAVRQGQRQSAKEKHRGLKTKLIVNCSTASRTGKEVDGCEVVLSNDKLYLAVASPEYEEVSEDDHPFAGYFLPYPDQNWGRQGEGLVSTISDDPPQLNWIYVDRDTHEVKYGNREVSESHVIGPWDVTKGPDKRVTLEGWEGFMAVKYGPGEWALYFDRDDDGLEGIIDPEMKTIEVVLVRRERKQEKPNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNP1</accession>
    <name>A0A9P4PNP1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_430629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNP1"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="36"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2446478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="329" mass="34620" checksum="2FCCCD6D67F685EF" modified="2023-09-13" version="1">MQAIRRPMSSALRKAAARNTYATSSTPYADTIKNLRINGDTKVLFQGFTGKQGTFHARQAIEYGTNVVGGTNPKKAGTEHLGKPVFATVEEGIKQTGATASAIFVPPPLAAKGIEEALTAEIPLVVCITEGIPQHDMVRITDMLKSQNKTRLVGPNCPGIIAPGQCKIGIMPGFIHKRGRVGIVSRSGTLTYEAVNQTTQAGLGQSLVVGIGGDPFSGTNFIDCLKVFLQDEETDGIIMIGEIGGSAEEDAADFLKEYNTANKPVVSFIAGISAPPGRRMGHAGAIVSGGKGDANSKITALEAAGVIVERSPARLGKALYDQFVKRDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP50</accession>
    <name>A0A9P4PP50_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_227494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP50"/>
    <dbReference type="OrthoDB" id="5408025at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027915">
        <property type="entry name" value="DUF4452"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39615">
        <property type="entry name" value="YALI0E17897P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39615:SF1">
        <property type="entry name" value="YALI0E17897P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14618">
        <property type="entry name" value="DUF4452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="188" mass="21257" checksum="6CC566AADE694268" modified="2023-09-13" version="1">MFTYGAQHHQPHLNAHNNHNHHGGRSRRAPRISAAQHNKQFRQVRTPKEFVVEPPTMLAFRRDFEAARSFDLEDDELFCPFHLLTEDDLQSIHSSGSDRSSLSSGSPDQSPLQHQLQPTPSFVLSSAPNPYTPASFQSSNSSQPKLHQPLAQRTRNAIPIVDPSTRAVASPPPSISPNRQMQQQFRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ68</accession>
    <name>A0A9P4PQ68_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_517804</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ68"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="61"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2448215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="53775" checksum="D853CEF219714277" modified="2023-09-13" version="1">MAYYQQDPSSSWPAPGRQASWEQPPPPSRSGASSTVNRDEFSAFAFASQFEDVERAIENLAKSGAGKGFGFPQYAGRRDSMPLMGGGPRPPYQQDLADPRMGGPQRHHSVSEYDGSRSHSASNVQGYYQNQRNYGPRPNDADQMAQTKRRMAAQRERELRNYHQEQQYHRNVSGSKSDRSMSPNANTMSEDERRELIARQHRALYGESSQLYNNNPTSSQDVRVSGAGRGPSPLAFDPFGMQAAGATGEAPVQMPTRGDKDAAGGAQEARANSNSSPASSQNPAFALFDNAQQASRTSNSSPGGSPPRQGSKVNGSGVAPIGTRPIANQGQPAGSSLSKGRTTPLPSPLSYNSYNASEQNANANATTSASLNPPSTVTDNKGVGIGWNKGPWGSTPNQGSSPRATSPANNAAGSTTARPSSPKPPGGPATVMRRKAAADRAEKSANQRPSSTRAAGAGGSSSTMLRLYTDESPGLKVDPVVVMTLSVVFIFSVVALHVIAKVMRKFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR33</accession>
    <name>A0A9P4PR33_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_481745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR33"/>
    <dbReference type="OrthoDB" id="3797168at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="145"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="517" mass="57626" checksum="8D604537362C00E1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRL8</accession>
    <name>A0A9P4PRL8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_452095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRL8"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="127"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="229" mass="25469" checksum="31BCCF1C3E3781A8" modified="2023-09-13" version="1">MSVAPTEALPLDGRSKDIKTSVVVLIAFSSILVGLLLYVSRKKHIFFQATDHFLWTGHSPADLEKYLKWLSFGQLLNLYGMALIKLSICPYILKLDFTRLYRIIIWLSHWDIAATQSGSCWGDKSRETLWGVRAVFLLGLVTTSISALKLYEMKSLYASSDPTYASVNLSIFAVSEVFVGAFTASLPPLRKTFETLLRRVLPESSMGSGAPSNVNGKYAKPKHVLDNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS56</accession>
    <name>A0A9P4PS56_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_354833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000100">
        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="754"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1271"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2447989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1374" mass="151611" checksum="049E7734EA1CB875" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS80</accession>
    <name>A0A9P4PS80_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_517927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS80"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="55"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="686" mass="74112" checksum="A3D7108E1E550642" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSC1</accession>
    <name>A0A9P4PSC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_508150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSC1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040194716" evidence="7">
        <location>
            <begin position="26"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2448079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="409" mass="44077" checksum="95A7CC2018A1CCAF" modified="2023-09-13" version="1">MTSWFNGLCLLTCWLPNIYVPSGQSVPGSEPDITGKTFLHTGLMYNITSAPNVNIGGQIKSVWVGNVVGGGSVVNGMAFDRASAADYDAWEQLGNNGWVWNNLLPYFKKSTTFTPPSAENVKAWGTTYDVSYYGATGPIQASFPEFEYPAITTIWATYKAQGVLLPEEHALGNSVGAYWTPTALRPKAQTRSDAKNCYHDPVESRSNLVLATGKTVNEILFDQGLLTGYKAKGVRYVSRKDNSVQQVYASKEVIVAAGSVFTPHLLQLSGIGPKDVLNAAGVRNMATPNPLSGLDPAFNASAWAQYNANRTGPITQAHGSSLGFLSLQTISDNYQSIISTIKNQNARTYLPSVYADSKLLAGFNKQRDTIADLHSRTDAAVAEFPTVAFGVAISSLQRLLSRGTVTSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSE0</accession>
    <name>A0A9P4PSE0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_402884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSE0"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF283">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="244" mass="26768" checksum="0C9720E7BCF23788" modified="2023-09-13" version="1">MFLFFAFSGTQVANVHSAGSSNTTTGADTGFSTQVMEYISLVFGFSLMVNVWIFFRISGGLFNPAVTFAMLLTKAMSLVRFFLLLIAQLAGSIFSSFLVSVMFPTPLNVRTTLSADTSLVRGVFIEAVLTAELVFTIFMLAKEKHKATFIAPVGIGLALFVAELVGVYYTGGSLNPARSFGPCVVTGIFDREHWIYWVGPAAGAVLAVVFYNFIKMLEYEMANPDQDANDHDIKQKQNNNEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSP0</accession>
    <name>A0A9P4PSP0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_481596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LCL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSP0"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040155457" description="Long chronological lifespan protein 2" evidence="5">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="122" mass="13788" checksum="854C9D0663BAC64F" modified="2023-09-13" version="1">MELRVVILLLATLLVQTATAQFGFFDQMFGGQQQQHQQRQQQQNVRSDSSWYQAQYENAHCDKYLCPGTLSCVHFPHHCPCAWESVEDKVELGEGLAVCASKGGYKDGETLRKIELARKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTF9</accession>
    <name>A0A9P4PTF9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_403889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTF9"/>
    <dbReference type="OrthoDB" id="3783411at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040333166" evidence="1">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="103" mass="11171" checksum="49E00F27E3883BD0" modified="2023-09-13" version="1">MRFALLVFASAIAASPFPWAKVEAVTSALSSVLAAPTDNATRTRHHNHHKEPTPTFKLPCNCQQPIIPAGQMNAKELCEYKYFLNIACFHQAQGGCASPTLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUH5</accession>
    <name>A0A9P4PUH5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_428985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUH5"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2449036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="503" mass="55781" checksum="1AB22C5B6B8E4445" modified="2023-09-13" version="1">MKVKLMVQKSVNLNAHALLASIKIRLVDVLETLLAAGMDPNMHRLHDDKWEYKHAMGYTRTALEEYPLWVAATQHGPENDKLTHEERETRDNSVKMVGLLLAHGADPFATFKSRNPSHMSEHVRSVINETKDSVLISVEELDAEPEFQKVSILHDLLEHGNLVHPILEMSNLDPHHRDSRGRTVLHAASLSRVGIHAPIDVLLFGAGQEVEGPRQSAPSFLHHLSSIGTDKLAVDNQGRNILHLMLVAANGHLVSCHPILWVLPLLSEAEITALTTQADVYGNTPLHLALRYAILRRDASPVEALLEAGADPFAQDNRGNTALHILAYRVAESEAPWTLFTKMLELGLDINTRNSTGQTPIFNLNRSLPVYIGHVGSARAEYVTPAQALALFEDAGADLFARDKHGAGLLHVAAQLKQKEFPRSNRGMRHEQMRVATRFELLVNKGLDVAMEDEKKRTALDVAAAYDNQSVLKLFDKDNVRNKVTAAELEEVGAEYDSDDMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUL9</accession>
    <name>A0A9P4PUL9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_426880</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUL9"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="59"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="301"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2450527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="401" mass="45889" checksum="D9AED73DCD5136D2" modified="2023-09-13" version="1">MGASNDEAKRKAAAPLNPESPSKRPKQDSETPDAAPPQPKKLIPFPEKPAVIEEQTGEIEFRVVNNDGKRESTVILTGLKCIFQKQLPKMPKDYIARLVYDRTHLSIAIVKKPLEVVGGITYRPFHGRQFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSDVMHFLTYADNYAIGYFKKQGFTKEITLEKSRWMGYIKDYEGGTIMQCSMVPKIRYLESGRMLLKQKECVNVKIRSVSKSFEVHAPPTQWKNGLTKIDPLTIAAIKRSGWSPAMDELARAPRHGPNYNQLLHLLNDLQNNSNAWPFQQPVNKDEVLDYYDVIKEPMDLATMEEKHEKDLYPTPDDFVRDAKLVFDNCRKYNNESTPYAKAANRLEKYMWSKIREIPEWAHLEADYGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVT0</accession>
    <name>A0A9P4PVT0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 52A12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_377051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVT0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="525" mass="59268" checksum="49CBA12A86BDF400" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWC4</accession>
    <name>A0A9P4PWC4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_517687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWC4"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040260583" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4185" evidence="2">
        <location>
            <begin position="209"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="374" mass="39934" checksum="9F6F7F7ACB8A38BE" modified="2023-09-13" version="1">MRCLLHTTAASLLASPALGLVARANLPPKFTVEPIGIQSSNFPDVYRDGGGGGTINGLNIMTFSDTTTTTGGINGSMKGFTDNTIAYVGQNGASLYQTTDFGSNGVPTMPIPFTQNETQYTTSHFPTDGTRCVLWPQSSIATLPTPSGPDLGIAIYPIALYNSTSNTQTDLYTTLVEITADPATGPNVHRVVPRLFYAAESPLYGAFAAILAHESSHLYLFSKEWHAPTLSGGIRLARAPISSYKNRSTYTYWTGTAWTPDLAAASTAPAGLLFEASLSTGDVFWSDYYNTYMAVYFNNFADSTFYMRYALEGTVTGAWSEEVVLAGTVPGGGLQGYNYAGHAYPTFGVDGRELVLSYTVAGGALTGMLRVVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWK9</accession>
    <name>A0A9P4PWK9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysine 2,3-aminomutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_402524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWK9"/>
    <dbReference type="OrthoDB" id="5396721at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538:SF0">
        <property type="entry name" value="L-LYSINE 2,3-AMINOMUTASE AQ_1632-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="LYSINE 2,3-AMINOMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49986" checksum="ECDE7D8E1B7B7B4A" modified="2023-09-13" version="1">MFTKSSIPSLFKRYAAPMDPLPYQVAANVFPMRVNNHVAGDLIDWSNVPDDPIFQLAFPQPGMLMPNDLATMSKAAGLGMSKAGLQHLAEEIRAKMNPHPANQKTENVPRIGEETFAGMQHKYRETVLFFPSEGQYCHAFCTYCFRWAQFTSVGSSQTFKSSNGLQLRDYLLQNPQVKDVLFTGGDPMVMPPQVLRSYLEPLYAGPNAPKTLDTIRIGSKSLAWWPYKYTTDPDAKQTLSLFEEVVKSGKQLAFQAHFSHPRELEHPAAQAAVRNIRMTGAQIRGQAPLIRHVNDDSNIWRKMWNLQTRLGIVPYYMFVERDTGASHYWNVPLGRAHKIFNEAYRGIAGTARTVRGPSMSASPGKVGVIGVEMIAGEKVFALQFWQARDPSWMGRIFFATYDPEATWLSDLKPAFGESEFFFEPRYRELVKMAKDKASGQIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWQ6</accession>
    <name>A0A9P4PWQ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_478669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWQ6"/>
    <dbReference type="OrthoDB" id="3765547at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="315" mass="35732" checksum="A4FC12BA5E9D9045" modified="2023-09-13" version="1">MSYLLYPLDASETTKPTYAVGHPDAVDEVILRDLRQWGWRVEETTNNDPAWLAARQDYHKRMEADGEGGEKKSSLWDYWRNENAWRAALESGKSRERKRLTKSPQPRTASSHRSSFTRLVTRKEAQKLPGAQRVPQAGERQEEETYLMSGANQERKTIAEIRQQAAQKKEASEDRNRLDPAKSLGRLDPKGPSICHYASGNEASTAANAQLERELLHEIKEWVGIEGILKTTQVSVISEEGICVDEKGEQVYFPPKWNLPLFPWEEVSRSSSTKSKDSSAKGSLEYVTADIAAVFEVTDRYQEKDEPDQEAYGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX40</accession>
    <name>A0A9P4PX40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_503744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX40"/>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="142" mass="16397" checksum="FEB029BC434749B9" modified="2023-09-13" version="1" fragment="single">EKWKTWSANATSTPYPDFGHPTNRECRLAYDILYNLHNDAMEAEFNGTHTPETIPFVLDALIVLSQTTSWSNAKRVMDNMKQFYGSIFAYDKIYAGGSEKLQDIIRCGGLHIRKSKIILSILEEVKRRYGRWNLDHLLEPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZE9</accession>
    <name>A0A9P4PZE9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_515661</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZE9"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="56"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2451694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="477" mass="52190" checksum="3C28C5AB5F498D85" modified="2023-09-13" version="1">MCPSIEETPTNGAANGHTNGKADEFTPIEARPNPVPHHKSSPYQPVGDFLSNISRFKIIESTLREGEQFANAYFDLEAKIKIAKALDEFGVDYIELTSPAASEQSRLDCEAICKLGLKAKILTHVRCNMEDAKIAVQTGVDGLDVVIGTSSFLREHSHGKDMTYIKNAALEVIQYVKSQGKEIRFSSEDSFRSDLVDLLSLYSAVDKVGVNRVGIADTVGCASPRQVYDLVRTLRGVVSCDIETHFHNDSGCAIANAYCALEAGATHIDTSVLGIGERNGITPLGGLMARMIVADRDYVMGKYNIKKLKEVEELVAEMVEVNIPFNNYITGFCAFTHKAGIHAKAILNNPSTYEIISPADFGMSRYVHFASRLTGWNAIKSRADQLGYNMTDAQYKEVTAQIKLMADVKKITLDDTDAIISAYHHNIVNGEKKPLLEGLSAEDQAKIDAAEQKLGTVKEKRQLDAEAAADAPPAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6A0</accession>
    <name>A0A9P4U6A0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_163268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6A0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="164" mass="18009" checksum="8D4EB8582701135B" modified="2023-09-13" version="1">MVHAMVHAMVAFQNLDGVRGVELHCSTTVQAVSTAHLVRPSETTRILPEYPVERDAIYLTGSMSMLMYSCRLAQRCVVAAILPAFQSNLTACKRYPAFQVHVYTYKRAPLGRNTPVAGAAFPASMFCLHCTAQTAVVPPSGSGIHRWVFRRASLSCHGSRFPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6F3</accession>
    <name>A0A9P4U6F3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_397826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6F3"/>
    <dbReference type="OrthoDB" id="2125396at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="428" mass="48686" checksum="FFAA160F16915DE5" modified="2023-09-13" version="1" fragment="single">MEVDFGLNMQRTESPHANYLPDELLLQVLDCLPLTEESQGTLWNFVLVSRQWYSVGISRLYASPFLVGIRYTHFVRTLCPSVIPRIKRSELAGLVKHLDLSRIVHQGAKSITARLLGRTKNNLELFVAPQASFAINCWAALSKCARLKVLDLGLVSEAISYQSLNQTLRQLGSLEELYMPRCSTEFGLGPEFLTVRLHWPPKLQHLSMSGSVNGKFLWELLRQPETFPTSLHSMALLHCPGLDQPGIKPLLSNLADRLTVVELRDLPAVKQGRFNNVMGWLPHLTTLTIALDYIDDDFGRRPPDFAPNTHWHLARPLTALTLVTCGNHEADPRRAFTLVDLWDLIDTRFLGRLRRLGVAASTGWERVDEGALWETVRVGLEALDQENWEARRWHYEFLRGVPEGMGYEEWRGTLAGWRERPRAAVLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6I8</accession>
    <name>A0A9P4U6I8_9PLEO</name>
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        <submittedName>
            <fullName evidence="3">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_372448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2438052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040237249" evidence="1">
        <location>
            <begin position="18"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="537" mass="56759" checksum="931B0578D6DF0A55" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7W7</accession>
    <name>A0A9P4U7W7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">P171DRAFT_122503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FHA_dom"/>
    </dbReference>
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        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="701"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="701"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="390"/>
        </location>
    </feature>
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            <end position="1213"/>
        </location>
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        <location>
            <begin position="210"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="421"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="809"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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    </feature>
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        <location>
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            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2439432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1213" mass="130435" checksum="C5A827E5A5840300" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U820</accession>
    <name>A0A9P4U820_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_344532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U820"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="301" mass="34984" checksum="9439C7443BAB1FB6" modified="2023-09-13" version="1" fragment="single">MRLINAHTKRFEEFFGEVPPYAILSHTWDAYEIPFKDFYNLHVHEENPQASQKIYDTCNQALEDELDYVWIDSCCIDKSSSAELSEAINSMYIWYSKAQTCYVYLSDYDPHAGNSSGFIHDGFEKCRWFTRGWTVQELLAPHHVEFYDKTWSYFGTRKELASTLSNITRVPTKVLDGSKEVEEFCVAQKMAWAARRQTTREEDTAYCLFGLFQINAPLLYGEGGVRAFERLQEEIIKKTNDLTIFAWMNPGPRMSGITSVLAPHPRYFSRSQHIRPQNPIGSNPEFKVTNKGLKIKTFIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9K4</accession>
    <name>A0A9P4U9K4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calnexin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_433659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9K4"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040535464" evidence="9">
        <location>
            <begin position="19"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2442086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="568" mass="63039" checksum="C62F43F1E337C3FA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA04</accession>
    <name>A0A9P4UA04_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_456618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA04"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="176" mass="19579" checksum="2966F45C1EEC63E4" modified="2023-09-13" version="1">MSNRAPSIACIGVIGRHNNPLHISLFPAEERAPLEYQFLLSSCLDIFEARLPHKTVDQDFGLLQAVDERLAMYGWLTNTGVKFVVVVDMEGRPANPLDTKSSAAVGLRDADLKPAFRALQTAYIMLLRNPFYTPDEHSPIAPNGEQRYGSTQITSRKFIQEIKRIGDAWAPGVNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAA9</accession>
    <name>A0A9P4UAA9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_487002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAA9"/>
    <dbReference type="OrthoDB" id="10584040at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040200714" evidence="2">
        <location>
            <begin position="18"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="518" mass="55176" checksum="2F37C33C9FC89206" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAL0</accession>
    <name>A0A9P4UAL0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_414818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAL0"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="9">
        <location>
            <begin position="29"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2443375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="334" mass="34939" checksum="C3DFAE8381AB1824" modified="2023-09-13" version="1">MISRTSIKTSPHLTRIVNQNLLSSTAEPSSSQIELLFKCENLQYTGSFKFRGACHFLAKLDDQDLKNGVVAYSTGNHAQAVAHAAQLASKTRNKPIPSYVVVPSDCPPKKIAAARSHGAAVLLSGTDPNARVLLAEHIQRATGAVLVPPADHLDIVLGQATAVHEFLQQAAQAGRPLDAIIVPSGGGGLLCGAIATCKPRGVAVFGCEPEVGGPGLATALERGRRSLEIQGPGSIADGLRSLTGEANWEHICAEGNVKHVLTVGEVQIEEALRVGVRELGFAVEPSAAVPLAAALFSDAFHRWVADADRRVRVGVVLTGGNVSMEDLAALVPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBG1</accession>
    <name>A0A9P4UBG1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_27622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBG1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="526" mass="58312" checksum="8A86624FD9F93EEC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBK1</accession>
    <name>A0A9P4UBK1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Alpha-galactosidase</fullName>
            <ecNumber evidence="5 12">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_455086</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5 12"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBK1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005995">
        <property type="term" value="P:melibiose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006215">
        <property type="entry name" value="Glyco_hydro_melibiase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00748">
        <property type="entry name" value="MELIBIASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040435482" description="Alpha-galactosidase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="14">
        <location>
            <begin position="318"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2444216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="469" mass="50781" checksum="9CFFA96AF4D0E4C8" modified="2023-09-13" version="1">MHRATPLLTAAIFLGATTAYNQSRYIDNSSGSPEVIIPGASSYNGLNLVPQMGWNTCNAFGCDADEDLLLPSARNLVDFGLRDLGYNIIFLDDCWSIGRNSSGYLVESPIKFPSGMVSVISQLHDMGFKFGIYSSAGTFTCARHPGSLGYETQDADLWAGWGLLNKTNREIIYAMCNWGNDDPYGWACLIANSGRIPDSRCPCTEAPGCAWPGFHCSIMNILNKMPSITSRTMSGYFNDMDGLEVGNGGQDDNEYVTHFSMWAMNSSPLMIGTNIATLSPANYAILSNPAIIALNQDPSAGAATRKWRYSVDHDDYGQGEISLWSRVLENGDTVIALLNAGNSSRTMNATMDDIFLDQRTAGAYKAPPELSETWDVYDLWASRMSNEDAKAILNGGNGTASNATSTELYNATATSYADGLKNNVTALYSAHVGNVAPSGTFSAEIARHSVGVYRLRSQGSSSLRKRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBM0</accession>
    <name>A0A9P4UBM0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_414194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBM0"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2444276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="256" mass="26850" checksum="5C231AAE08F9F8B3" modified="2023-09-13" version="1">MIKEAHLSGKVAIVTGSSRGIGAGIALELAKKGASVTIVFTSPKSEAGAHDVASQIEQLGNDSRAIVVRANLREVDAPDRIVKATLEAFGTKIDILVNNAGVLFSKSLRKTTADDFAAIFDVNVRAPLLMTKAVEPHLRAPGRIINVSSVGARQGFESLAMYSSSKAAIEGLTRGLAAELGNVGHTVNAVAPGPVVSEMLDDVPQDTVDIQLKTTPVEHHHGTVDDVAQIVAWLSDDSARWVSGQTISASGGYTMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBV1</accession>
    <name>A0A9P4UBV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_443599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBV1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="253" mass="28941" checksum="8EFAA3F670732D1A" modified="2023-09-13" version="1">MGISLSDIKGMAYSTHAVRFDEKNLFANLPKPTRPKRPLEYFSKYVKVCRDQNLTRAKSQSGTGHRAPTDSVALFEFLVTSQQDSPATRNKRVILTPIESLVVFKNVMLEDEFCLMFDLEGLMLGCRQFLLKVQRSAHRATDYHRLREIGLFLIALGPPGSKQEVPKIVWEDMHSIIQEYEENEWIKAQKRVGTVKGPLVESDEELNKGTALVVNRFEMKRMTKLARVARMCQSTSLDIAGLREFLWIYIVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBW6</accession>
    <name>A0A9P4UBW6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_442514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBW6"/>
    <dbReference type="OrthoDB" id="4121058at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="497" mass="54099" checksum="06EE2AABFB95E48A" modified="2023-09-13" version="1">MSISSFFNDLWQAAFAEQDLLKQPRTTHQTTSGEIATLLPVSKAHNSTSPTSMQKPQGASKRVIDLDYASPASSEKFQYRSQSEKQELVYVEYASPDPSEKFQYRPCDEDEKRVDANCTSPHTSDQPQNDTQSQCPYGLFQDHDHWKKKDWAAAVTIGAVAVVCLAVVVGASGSGGGGSFAGHGSGSNRRHDPEDGDCLAEFTLHPYLPPAVDSTEKKEHHQVESGTHIHNALLHHQVESRTYIHDALLHIKDPGPTSTTLFFTIKLNPEPTSTTLSSTIKEPGPTSTTLFFTIKMDPAPTSTTLYAAFTVGWRLRNHDNREVRFGFSEDVPGGITGLVRKVAGRGNVEFDGGWRAGSSQAGDVQAEWDGFRRNGLCTSLDRRTTSVASYGIRSLIAASPAYSTSGLYAPAAHSRRISSIHAPCALLTLSLHAAGSSDRRTTCSQLWHPQFDRSFAAVLDSRAPDCCSLYQDAYEGNLLRSASLSAAALESRSGYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC02</accession>
    <name>A0A9P4UC02_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C19 ubiquitin carboxyl-terminal hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_445164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC02"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C19 ubiquitin carboxyl-terminal hydrolase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="207" mass="24244" checksum="A08B8266038DBEF7" modified="2023-09-13" version="1">MPRTKKHAPYRKKISTRNNGVDLFDPDAPKRHRMQAAYDYRSQFMSSDWLTNPVGGNQTLRVAPHLGPRLISNHSNHCYQNSVYQALMHIPIFLQWISRHQFTEECDEVDPPCVRCSMRVLMRRYWGTVPLQNSIADDSIPLQEIREQAYASGLFQPHQSGSPGLSRRRSSERFLRQRECGNRLYPSKPTTYSKERERGNYRDVYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCA9</accession>
    <name>A0A9P4UCA9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_388669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCA9"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040495822" evidence="7">
        <location>
            <begin position="25"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
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        <location>
            <begin position="401"/>
            <end position="420"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="451"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="577" mass="63565" checksum="C704C249251B6C08" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCI9</accession>
    <name>A0A9P4UCI9_9PLEO</name>
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        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">P171DRAFT_485664</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCI9"/>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040181861" description="Concanavalin A-like lectin/glucanase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19431" checksum="A382BC05966B1775" modified="2023-09-13" version="1">MKLLLQALALVTTALGALLVDFNAARGDDPKVLGLRNLEAARDDKRKFVANNANDNGANIPLSLEFVDSTHLQFRYQASSSVGRVGQWQKTINPNQRYKIGIAINTASPGWVELYIDGKQQVFGDERVKRLTANTFPGRADPKFGAYRGEEIDIDTFVYDVQIGENKEDVARAAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCQ6</accession>
    <name>A0A9P4UCQ6_9PLEO</name>
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            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
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    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="614844at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Beta-1,4-mannosyltransferase (Alg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2445476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="494" mass="54802" checksum="EE9C8AC209C2DC87" modified="2023-09-13" version="1">MFNLHDILRDDFLTEKGSRLFDVALYAILGLSTLFTIILVTLPSQYDPYKDKPLRAVNERGEEIELKRKDGKKKVDFKAGRTTQIVVLGDIGRSPRMQYHAISIAKHGGKVYLVGYQESEVHPDVASSDLITIVPLNLSPSLLRSSSKLLFPILAPLKALHQSWTLYRALGYASEPARYMLVQNPPSIPTLAIATIVSFLRNTELVIDWHNFGYSILALKLGPSHPLVKISALYENAFSRLAAQHITVTHAMARVLKRNYGVTAHALHDRPAALFRPLNASERSKFLSRLPETAQYAQDLAKGSWKLIVSSTSWTADEDFSLLLAALETYSARATSQVSLPKILAIITGKGPQKEHYLSLVEKMNQEKKLLNVVIQTAWLTPGDYATLLGAADLGVSLHTSSSGVDLPMKVVDMFGAGLPVVGWGDFEAWPELVKEDVNGKGFNSSEQLAEQLVELFGNKDSVLPILKKGAVEESKNRWDDEWDRVGGKLFRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEL2</accession>
    <name>A0A9P4UEL2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_483278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEL2"/>
    <dbReference type="OrthoDB" id="3922703at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040198867" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27585" checksum="93B83EE2E9E6C7E7" modified="2023-09-13" version="1">MHLSLLLFLSPLAIASPSSSNDTQTWTITRLDYHYMTDDPGFGPPRTQRPGTRRRVSDTAPSNANPPFPDSTDFVLEHADMPWPASAVFNTTLSFDVSIPRANASNGSWHAVCELSWDRTTRPEPYAECVEVEVGGDEAKRGIGMGGVYFTVEKWNATGGGDAVVQMPFILKMWRFTIDAEITLWEMFGNATISCDDPGSPTSYLTCMMGRPLDGMRCKLHSLNNVDLSNKKELQIVAERCREPGECPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF91</accession>
    <name>A0A9P4UF91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_442195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF91"/>
    <dbReference type="OrthoDB" id="10390201at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="249" mass="27508" checksum="56B04096E2290439" modified="2023-09-13" version="1">MQWSLHAPASDLDEPEGEQMRQEDVETNKYTVPHARCVCVCVCVQAREEHPLSATLSTNAAGVQSRTGEFGTCSTAELVKQIHRLQYQEHDDPPPYSKAVKLSTPQDCLPAPARTFSDILERKNKLEEDGLLKTSSKRTPPFESDSELNEASDTRGMLSNILRQSGATPRQSDAGVLGSFGCTYVPDENGVKLRRKKMTAAANQGTDDIQTEPQLNDPVAIDVNVEAQAKPRTPNRWRGVILTIRGMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFH6</accession>
    <name>A0A9P4UFH6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_482256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFH6"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="338" mass="37284" checksum="6E94378C9CA24BC4" modified="2023-09-13" version="1">MSNKPLPKDGFDLSKVPTGPFSSQPKHNEYQRCTSKGAMLMNAMTANIKDAGNFLNPPIASAESKFTSSPAWQDLARWGYEYCDATTVDAFYGDFKMNWGISKALQSNGLSDAVIRSPPPPPTRPRCARCHNAVLYLTHYDLLKKHTPPCEQSYLVGGKKYTYTGATCVVSINPDQGVLIAMDRTSPTHMVKCHDNLITPPDLVHTSDIMFALWKDIAGDHRIRDLHYFLSICIDNDVSERVIQEVTKGQLASYPGRVFSTEDPEGQALLGMPTAVAIGYLLAQHKEAMGVRFVDSVCVFKSDSQSQSPCLMFHISSGDDDGRSVDGEGQDKKRARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFR6</accession>
    <name>A0A9P4UFR6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-aminobutyrate aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_428422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFR6"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="51690" checksum="8DBA8CD58DCCE367" modified="2023-09-13" version="1">MSLYKGAALRRALAPTSVRVPSSSKRAFSASMPHANEPTFDAAAFGEQHITKGIGRLTKHVFEDGKGTYITTDKGVKLLDMTSGIGVCNLGHCHPKVSEAAAKQCMKITHAQVNIGFSSAQVALLRELIPILPHPSLDTVFLWNSGAEAVEAAVKLARAATKKQNIIVMQGSYHGRTCATAAMTRSKTIYGEGHGPLMPGIFATAFPYYAQFGLPSDTPIDELVEKSLFQLKLTLSQQTAPSDTAAIILEPVLGEGGYVPAPPAFLHGLRKVCDEHGILLICDEVQSGFGRTGTMFAVEESGVRPDVLVFAKGIANGFPLSGIASTNEIMNRQKPGTMGGTYAGNAVACAAAKAVIEVFREEKVLDNVAARSEQLFGFLNDLKNSGSKAGNLIQDVRGRGLMVGVQFQDADVIAQSQNEAARKKGGAGQIAPKVVQECVKRDMLLLSTSVFDVLRFIPPLTISEAEMQEACRIFGESLEAVAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGX5</accession>
    <name>A0A9P4UGX5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_405757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGX5"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24952" checksum="547580782F133F4A" modified="2023-09-13" version="1">MSTCKSAARISTAVRPSSLLPRIQTRHESTTRRHKKLLTVQQAPSYTPTRPEPTLIFNPPSSAPSAYHTPLKFLPQNDKRRALYASFLSTSTQRAHRTATSPVAAPGTPLSASSFLPPTPSAHLPPPVRQPYEKKYHLTDVDIKEIQRLRAEDPDRWTRVRLAEKFGCSQFFVGMVAKNGVKAEKVAREHDRARGRWGEMRREARHERERRKELWGRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHF6</accession>
    <name>A0A9P4UHF6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_349442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHF6"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF7">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="514" mass="56664" checksum="50495FF4FEE4FBB0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHG9</accession>
    <name>A0A9P4UHG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_427482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHG9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="75" mass="7995" checksum="69BA14E154E692E5" modified="2023-09-13" version="1">MSGQSMEQNMIAEGRLLVLKAIIHSVAIMNHCGLFPSCCSGHASCSAIGQAQPQACEMAAVTCELWYHDALRDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI54</accession>
    <name>A0A9P4UI54_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UI54"/>
    <dbReference type="OrthoDB" id="3798250at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="251" mass="27884" checksum="C121530A1B5286DA" modified="2023-09-13" version="1">MPTNLLKPTFPHLHRRSSSSTDIPKAAKPDAPKPVAHTPGTTSPTKPSAKSPTKPSAKSPTKPSAESPRPQRPQPVRAASHPGPAPQSSPAPKSKQPARAFGTNYRVRRTPPGTPPNERAHPTSQPPGYQAHPSVHDFAKIPSPAHSPPTRRKPVYSLHEADPAAKGRPTVVYTDEELLKRLNTIGEDEEVDVDRVNTVDRVREMDWEEQRRRKEDRDMEEWNRKEAKKAQKGMVRGFSWKGVKKTMGGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJF4</accession>
    <name>A0A9P4UJF4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding domain of Mlu1-box binding protein MBP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_516009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJF4"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0183">Conidiation</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="7">
        <location>
            <begin position="62"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2452135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="314" mass="35279" checksum="3BBB846A72413E24" modified="2023-09-13" version="1">MLSVQTSSSNLRQVDDFTALKYAAESRAAEEAARNPGVHKAFTPTRTFDRTGQICPAGRSPSVTASLWEDEGTLVFHVEWEGVSVSRREDNCIILGTRLLNVAGRSRGTRDAILAAEKTKHVAETAPTRLSGVWIPFERALELANQHKTTEDLYPLFVHDIGALLYHPVNHTTIWSDSGCIISPPYFMKPASYEEQLARLEQDKNERPLATRQSQEEKQEATKFEAYLEVLPSQKLKVMNTGGEERKEQERPPLGNWQLQDYQVKLLGLGQQNKKRILAARQAQKEKEEAAVLEGALEAFNLEERKDLGLKSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJK0</accession>
    <name>A0A9P4UJK0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_493261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJK0"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF57">
        <property type="entry name" value="CINA C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2451778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="456" mass="49883" checksum="12927F301A774440" modified="2023-09-13" version="1">MVLQRVKTIYRSVLFQIVIVGLVAFCEPGIWTALNNLGAGGNAKPFLNNAANALTYGLMSIGCFISGGISNKITAKWTLVIGAAFYTPYAAGLYCNNRYGNEWFMLLGAALCGIGASMLWASEAAIAVGYPEDDKRGRYVGIWMGIRQMGPLVGGAISLALNVKTKEKGKVTYTTYLGLVAISALGAPFALLLSQPQKVNRSDGTKIPYMRKTSFKTEARAIFRQLKNPYMLLLIPVFLAGQFGVTYQGNYLTTYFTVRSRALASFLTAIVGALANILTGIILDLPQFSRPAKSKAVYIFVLITVTGSWIWNAVVQTKLTRMADAPSFDLGDGPFFNSAFTVYMCFRFFYEILQTYVYWLMAEIKGAQGDGDISRTTGILRSWESIGSTIAYAIGAVHIPNQTQMIVGFALWAWTVPFTFMAVFGDWNKGVPKNGLESENESDVEVQRVVTGDGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P511</accession>
    <name>A0A9P4P511_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_467175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P511"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000005">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000008">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="223"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="367"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2438490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="682" mass="74798" checksum="9A4D3EF5CCC2FB99" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6N6</accession>
    <name>A0A9P4P6N6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_467110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6N6"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040334043" evidence="2">
        <location>
            <begin position="25"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="67"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="456" mass="49084" checksum="A4C96369188B672D" modified="2023-09-13" version="1">MGSLSFAFYLGALLVALFTSSACAQQKQKAPAAATFYLDQTETQFSLSLANDSSDVFIYFASPAYSWVAVGFGESMENSLMLVMYANAKGDNITISPRLSTGHSEPSFAPSINLDILNGTGIHDDMYVLRAVCHSCRVWPNAFLDTTSPAAPMLFAFGPGTATLSDDPAAPLRRHVRFGTFTMDMRAALTADAGVPEANPQLRNAAITRMAKDRDGKDLAHAVLGCIALFVLWPLNVVLAAFFRNIKLHVGASLTILLFLVISFALGIATSPQYNRSKTYTTPHQLLAFVALLPTLLTAVLPAPAFKPLKDKIPTLHTALATLTFTLLVLSGGLGLHLAQTPNPLVLSYVAIALFVAAFTTVVLLCVRRRGSAYARATLRRRLGEEEEADLGRARWGVRKKLSRESEGSWEGGGMGQGHARSESQGSFVVGRGTMPGPQYLMNMHPGVPVYVNGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7A3</accession>
    <name>A0A9P4P7A3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_435588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7A3"/>
    <dbReference type="OrthoDB" id="3778539at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="121" mass="12618" checksum="1443728D77566004" modified="2023-09-13" version="1">MHALSTLRLSGILPGSLRRFIVPSWAPPNVTTLSIGAVDTADFTASNLGQFGISTASVDCVMEQPVDVHEVALGTPLQYGPPPRAVWYCGNCGDGPHNIAIQTGCSSCGHTKDSCCTTSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7Q7</accession>
    <name>A0A9P4P7Q7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_448481</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7Q7"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000010">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000019">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000030">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="166"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="319"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="485"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="9">
        <location>
            <begin position="700"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2438945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="883" mass="98016" checksum="8755D847EE08CBF2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P842</accession>
    <name>A0A9P4P842_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_466476</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF34">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2440170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="333" mass="37451" checksum="BB52295048CF7796" modified="2023-09-13" version="1">MPDEHPVSGSVYFCQPSKVAPAVFAALFFISGAWHLWQCIYYKSFKITALHPFCCLLFVVGFALREYGAFHISNVTIYLVSTICIYCAPPILELANYHVLGRILYYVPYFAPLHPGRTLTTFGAISGIVEILNALGVSLLANPNVKKQSTQDLGHILMKTALIVQIFVITVFVGIAGVFHHRCRKANIKSNKVQQPLLTLYISTVFIMIRTIYRTIEHFGMSRTPANPGADWDPMSLSPIVRYECNSFLWNGSHPRLYLPQDYHVYLAQDGKTELQGPGWESEQSWIMTFIDPCGLTALLAGKSSKGRKERPFWETNGFENVPRVKRDHGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P939</accession>
    <name>A0A9P4P939_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P939"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="170" mass="18894" checksum="F5E48D8E43A171D3" modified="2023-09-13" version="1">MTLNSAIDDFEVSIFLTEHSSRHSVLTKQKVFKDKPRIQSNSGKLTNWLKAGNSEQPLVINDGPTEPIVIREEEDDEPINLADVPEADGSEDQTTDAAVDEQDRKKKLGLNTSYDGFSIYGRILCLVVKRRGVRHQAGNNSAPVPSQQMLENWVSTQAQAEQVDDDEDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P992</accession>
    <name>A0A9P4P992_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_457616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P992"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF24">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53859" checksum="3ABDB599CD7EB8ED" modified="2023-09-13" version="1">MAEERLQKRRRTDDESAPDGFIATFLPTPTTEGQFNCLENIDPFLSPATSWGIDEFAHDPNYLASQEELRALLFTTARSAAPTRAGTPVEDDDTSAEPSFNFSVKQILAKGRRVQYLKNYISAVAPWLDMFDSSHTFAIQLPALAKDSCPLLFAILAIGARQLERKEKTQSSFDSLELYQEAIRLLTPLLQARDTHVIAACVVLCCLEMFSASAQDWRSHLEGCAAVFDAFGVNGFSGDVLQAVFWCYARMDVCGALISDGAESTLLKPEKWLPPNTSEELAESMFCNTSSPDMYANYAVYLCAKACELISERNRFVELGEDNGCNAGAFRDRWLELWDQLSRWSANRPREISPVFTTASLPFPKEFFAHWAAISSNQLYHTACVLLLSASPKHKALLVSSPTTSILWHAKRICGISLANPHEGCLNNAIQPLWIAGRLLSHSSEQTLVVKTIRHIEALTGWTACWRARDLEQFYGHKTRGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9A3</accession>
    <name>A0A9P4P9A3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_126183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9A3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="151" mass="16749" checksum="4E0D6BCD774A6542" modified="2023-09-13" version="1">MILDHGVDLRKSRNSGCPTLRFTSRPYPYVAASNPHPQDGYCLNVTIPKGATEIRRRHYGTPSAIGSQHVTENVQQAFHSSFSTRRGLQGHRHHASQLVLTRCFLSMYDEDGISASNTHLSPLGAPTAEVGGVIKDRRLRELREAPMSIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9T5</accession>
    <name>A0A9P4P9T5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_370349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9T5"/>
    <dbReference type="OrthoDB" id="3525430at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040174060" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="698"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="84419" checksum="4A17F32509EB8C4C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBA3</accession>
    <name>A0A9P4PBA3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_434458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBA3"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2441850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="221" mass="24948" checksum="1F500DDA004992A8" modified="2023-09-13" version="1">MDIRVLKPDDIPHVQLANITNLPENYFCKYYLYHAMSWPQLSYVAVDVSRPPKTPYDPPKIVGYVLAKMEEDPSDGIPHGHITSLSVMRTHRRLGLAEKLMRQSQRAMAETFAAHYVSLHVRVSNQAALHLYRDTLGFKVDKIEEKYYADGENAYSMRMDLSDLKAQFRLKEDGEESAGKDEGGAVGDEKGEPEKEKKRLVKVGRQLGVGDLVERNEAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC56</accession>
    <name>A0A9P4PC56_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_64933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC56"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="216"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="234"/>
            <end position="256"/>
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    </feature>
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        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="456" mass="50404" checksum="856282F34536FFB5" modified="2023-09-13" version="1">MKRSGSGRVARKIGAYDESSADSANSSQNELQSQPGTFCASLSQASVSDLRRRAVLTHGVDTVVRRPTFGKSKKRSSLRISFGPGDSDANDGDESSDGSVFTPKKSNLSRIAQERSAQLRARSPLVQEAPRPVTDEARPSYNQDYLAELRKSTPSKPKDLKPSAEEAEEQRALDIAAKFGSSAPISLEPETSAIPTQAEILEKKARRRRLAQEQNAYDEDEDRPWASDDDDDEFRTHKNEISLRPKEKWGETRLVRDDEDIAEGFDDFVEDGKIAMGRKAERETQRRRRAEMADLINDAEGGSGDDGSDDSEEERNAAFAAAQARSGRYGQKDLDEEDGARTPPRIAPLPDLGDILSSLQSDIDAKQQRQELIRRKLEELKEDKVRVAERKQYLQQQLQETAEKFEKLRQEEGLPALPANSAAGNRLIAERGLDSLGTTPIGTTPMDTGSSASDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCV2</accession>
    <name>A0A9P4PCV2_9PLEO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCV2"/>
    <dbReference type="OrthoDB" id="5373017at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="240"/>
            <end position="264"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="599" mass="65618" checksum="A370D0E8B03D7DC4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCY1</accession>
    <name>A0A9P4PCY1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_419191</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2587363at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040330566" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="11">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="179"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2441073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="275" mass="28405" checksum="DC9950B2B7C5162E" modified="2023-09-13" version="1">MFSILLPALAASFACVDAQHGAGAEGTEMGPVAFLWPPDRNWNAQADNIAPCGSRDGPSNRTEFPLTQGAVALTIADEAWNVAIRLATGNDPRTQEDFIDDQVVSNVSEVDPGHQCYKLQHLDGITAGTNATIQMEYWGEFEGENAGNNQSFFACADITFVPAADFNATAPCFNVTSSDFDAPSSSSSPTSSPSSSPDSTSNPSSSGSQSSGGGLSTGAKAGIAVGSIIGGLALIGLVALLMLRRGKAQGLKGKEEYELRAKGLGDGGPEREGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD67</accession>
    <name>A0A9P4PD67_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_80373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD67"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="149" mass="16788" checksum="08F45CDBF2501F1E" modified="2023-09-13" version="1">MAYADPQVKILFTLPRKVRDMVYTDLWKEIVALRFDHVIKYPGPSRCVCFETSVSATFRGKKITTSHYGSPPIIGSEKKHCSGTSDIPSSTCPTYFSGSTPIHTVSIKSLGRSRLTLVDNQVIGYKHTIHMFPGYPLWLMRNLSGYISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDR8</accession>
    <name>A0A9P4PDR8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_64357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDR8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="62" mass="7198" checksum="FA53A032768DF8C3" modified="2023-09-13" version="1">MSKLCSTVPIRRSLTVSSMILVRWEGWFLYYLLVIQAHSITSMPGFVRDISTQIIISEMDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDT2</accession>
    <name>A0A9P4PDT2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_523511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDT2"/>
    <dbReference type="OrthoDB" id="3797881at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="265" mass="29272" checksum="014208ABEFA24CD4" modified="2023-09-13" version="1">MFVVLLCSAALVIIPIFFVQHERFLASLPAPKRSDQLLVPPAGLQAPRKRGNASFDSAASDTATEGPSEPFPARAVTTSGYERRETKKPWNPPFPMRSKTLREAYLILPRSEDEKRDEYKGKGKEQERRSTSQMPPDEEDGVLNIGHVPVTDLPSWSAPAPSPMRSAPAQVRESPTAIQGRPEARVASTQATPESTSATIERKRSLSLVQTIVLVFALIIFLFAFAILVAHCMAWFVVYKTEARLGEVRKGLLRGGDMRVCLCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEF1</accession>
    <name>A0A9P4PEF1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEF1"/>
    <dbReference type="OrthoDB" id="3783760at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040457915" evidence="1">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="171" mass="17788" checksum="5ED896391A9F1CDB" modified="2023-09-13" version="1">MNAQTVFLGALALLPLLASAAPVETLGSKHTAFLASCTSTECPLGLCDPDDYNISGAAYFVNGPPTGTTASATAFAVTSNSRWEGVTRSVTWSRYGSFKINIDAKAASLPKGEIAGQATLTATGAADELFLCFKEGNTKFRTNYQGDAYSCTAAYYCPSIQTGTLTPTTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEK9</accession>
    <name>A0A9P4PEK9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_41122</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEK9"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="374"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="648"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="619"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2443604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1168" mass="128816" checksum="4C8EA46F2178DFAC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF11</accession>
    <name>A0A9P4PF11_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_365790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF11"/>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="575"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="626"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="706" mass="77287" checksum="F71BBE195F60C9A3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF67</accession>
    <name>A0A9P4PF67_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_50843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF67"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2442847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="543" mass="58449" checksum="4A1C1DF7D4248016" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFV7</accession>
    <name>A0A9P4PFV7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_417871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFV7"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="480" mass="54036" checksum="4D657399B203623F" modified="2023-09-13" version="1">MLSIAPIIIIALVSVYIFRNVKTYLELRDFGGPWSAGWTRLWLLRCHLSGSIHTKFTEINNKHGSTARVAPKMLVTSDHELVRRMNAIRSPFTRGPWYTCLKLHPESENIACYTDEDKHNDMRSRMSHGYSGKENVHLEQDIDDLIIQMLDLIEKEYVAKPENGLFRRMDLAKVTSYFTLDIISKVAFGEPFGFLAANDDPFGYAANLKQILPAIGWFGVYHELTNILRIPFIKSSLPSSMDKRGLGRVMGFARERILERFGDEAIVRQDMLNSFIKNGLTQLELEGETMLQISAGSDSTASALRIITHFISTSPPILERLLTEVDEAIVAGRISRPVIKNSEALQLPYLQACIKEGLRVYPPITGMLAKMVPKGGAKIDVDGVEKYAPSGTQIAWNSWGLMRNTEIFGPDADIFRPERWLASDNIVEMREHRLKMEETLSLVFGYGRFGCLGKMVANMELNKALIEVCVNAFAVENAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGS3</accession>
    <name>A0A9P4PGS3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_454552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGS3"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50600" checksum="A8F4D4A43A024A0B" modified="2023-09-13" version="1">MPSFYPRQNMPRQLPLTPPEFVPSYHSGCGGMPYQQPAYGGQPGIRSHDDGYDFADRYNQLSIAMPPMYPQAGTYLSSAPPSLPPPSSFYEPNGTSVLPPMRHSMGDAGMQQHRAQDLIQRPAQQPKEEKPVGGVSAKLDYDMEVMTDFVCEMALDVITPGRMMPPSFRKWVHQVLCATRLPSATIILSMFYLSSRMPMLAGLPKNDNHLFRLLTIALVLGSKFLDDNTFINRSWSEVSGIPVADLNQLEMDWLVAIEFKLHRDPVEHQGWNTWSNHWKTYEERAAERSGCPNKLSPIDTSVQRQRSINKPLPPLPMQQAYNPPPYDYTPKSAQPSFNNVASYSQYDPWRAANEHSPASAPTTGPTTPEYYGSAGPWAPEGYSRRTMFGFPPLSQTTPSQPQQSSNYGPPAYATQYHTPAWNTHGVNCGCMYCAQRHPSYFMAPGFGPQAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGX8</accession>
    <name>A0A9P4PGX8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_44348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGX8"/>
    <dbReference type="OrthoDB" id="4153178at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
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        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
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            <begin position="445"/>
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        <location>
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        </location>
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            <begin position="524"/>
            <end position="545"/>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="78486" checksum="BD281B50D8877C27" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4PH42_9PLEO</name>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="enoyl_reductase_like"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_N"/>
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    </dbReference>
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        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
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        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2443233.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="348" mass="36766" checksum="24AEC30FB3E3A970" modified="2023-09-13" version="1">MANQASWIPAATKQVAVGPAETYTPGPNELLVKIKSVAFTPIEAKIQKFGTHPIPYPNILGTSYSGTVESVGDGVTGFQKGDHVATIRAGKTLADPRFGGYQKFALAPVNSTSKISPSVPFNSSSATIINLAAITSALSIHLGLERPPLTGTATPKNKKVLIYGGSSSCGGLAVKYAASAGYEVITTSSARNKDFVASLGAATIIDHEQSPAAIVADLTKYGPYDAVLDTIGLPAPTAILVEYFESLGGGSYNTMIPPIPGTRDIPDNVKRIFAPYSFAFDEPQHKPLARWLYEEYLPQGLESGLIVPTRQHVVEGGLEKAQEVLDLMNQGGVSGRKLVLDPWQTTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHC4</accession>
    <name>A0A9P4PHC4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_416304</name>
    </gene>
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        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="10">
        <location>
            <begin position="289"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2442994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="79811" checksum="1676082DFC4CABFB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI11</accession>
    <name>A0A9P4PI11_9PLEO</name>
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        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_265413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
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    <dbReference type="Proteomes" id="UP000799764">
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    </dbReference>
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            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="418"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
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            <end position="32"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2445419.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
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    </dbReference>
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            <end position="425"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2445555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="46135" checksum="BD8C1C69E9A38F6A" modified="2023-09-13" version="1">MSDSETDVPSEAAVSNVIRDVVISIHKAGNDDHLTVNHVRTEAEQKLRLPTGFLKKDEWKNESKTWIKDAVERYCADEAAPEPSPKKPSKAKPKAKPEPKKKATKSTADSAPRGVKRKTAAPAKKPQKRKKTVSSDEESDAVLSNSPAQEDVASDADSEPAKKTARRQKQVVAEDSDEEDVAQPKPQHQEENKDAESEEDAQAMPSSKDAGRPATPPLAVDDGADSDLSSVIDESPVKKRKRNTEKPAKAAKGAKAKAQPKAKAAKAEDNPDQAEVKRLQGWLVKCGIRKVWGKELAKCDTPKDKIRHLKGMLTDAGMDGKYSVEKAAKIKEQREFAKDLEDIQAGAAAWGETISTGRPRRAAARPIQTAILPEDSDDEDEEKPQGAKDAGTEDDDDDDDEVHSDSGSEDSVGGQNDDDVDEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4PIL4_9PLEO</name>
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        <recommendedName>
            <fullName evidence="2">AAA protein C-terminal winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_513675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF4">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="369"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="515" mass="58349" checksum="4A0DCB021401255D" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIQ6</accession>
    <name>A0A9P4PIQ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_281817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIQ6"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="368" mass="40648" checksum="FE48DB1089AC0004" modified="2023-09-13" version="1">MSSSKLFKPLKLGDIQLNNRVAMAPLTRFRADENHVPLPMVAEYYAQRASAPGTLLITEATVISQQAGGYANVPGIYTQAQIDSWKRVTEAVHKKGSFIYLQLWALGRVASPAQAEKEGITIKTSSPVALGEGYATPEEMTIDEIKETIGDFAQAAKNAIEAGFDGVELHGANGYLIDQFIQDKVNQRTDSYGGSVENRSRFAIEVVKAVVDAIGAKKTSIRLSPFSSFQGMKMDEPHPQFKDVIKKLDALNDLAYIHLVDSRIDGSVDVDPNPAEQLQPFVDEFRNPVLIAGGLQPASAHNVVDKQYPNKDVVVVFGRYFISTPDLVFRLEKGIEFNPYNRDTFYLPMKAEGYTDYPFSKEFLSAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIS7</accession>
    <name>A0A9P4PIS7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_387218</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIS7"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000121">
        <property type="entry name" value="Sterol 24-C-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 12 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="15">
        <location>
            <begin position="81"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2444717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="379" mass="42559" checksum="FC6C0325C4C5FFC7" modified="2023-09-13" version="1">MSPVALEQENHSRDADFNKAMHGQSAQAQGGMAAMLKKDKAAQQAAVDEYFKHWDNKAAADETEETRKARRDEYATLTRHYYNLATDLYEYGWGQSFHFCRFAHGEPFYQAIARHEHYLAHKMGLTDNMRVLDVGCGVGGPAREIVKFANVNVVGLNNNDYQIERATRYAEKEGLSHKLKYTKGDFMQMSFPDNSFDAVYAIEATVHAPSLEGIYSEIFRVLKPGGVFGVYEWLMTDKYDNDNPEHREIRLGIEIGDGISNMEKIDVAIKAMKAAGFVMEHQEDLADRDEDSAPWYWPLSGQMKYIQTIGDIPTILRMTKIGRGFVHKFVGALETIGVAPKGTQKTADSLALAADCLVAGGKQKLFTPMYMMVGRKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIX4</accession>
    <name>A0A9P4PIX4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_358115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIX4"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF119">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="570"/>
            <end position="571"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="665" mass="74237" checksum="6116D4C8DC451912" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ56</accession>
    <name>A0A9P4PJ56_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_521082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ56"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="208"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2445020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="380" mass="42328" checksum="067173DEC60B236C" modified="2023-09-13" version="1">MDAFIPQIRTLYAKSDEQTRQKIQRDLRDLQASFDNEWDLVIRLASGSVQMPLVKTGNDLSLFTTLSSSKDPLTLSTLATSTSAAPKMLFHLLRDMAAFGLIDQTSADTFAANRTTHIFADVHVSGSISHVYDVLLPSIYALPAWLAEHKYGEITDNKNLSFHKALKTDLEPFEWMKQHPEQMESLGHAMAIQREVHWVDSYPVAAAIGDYKAAADSAVLVDIGGGFGQQALAFKNKVVGTEGRIVVQDVQATLKSAPKVEGLEFQEHDFFNEQPIKGAKLYYLRNILHDWTDEDSIRILNAIVPALGPDPRIVIDEVVLPDAQLPWQAAWMDLVMMSSLGGVERTKLEFETLLDTAGLRIIEVHRYDARMQSVIIAAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK27</accession>
    <name>A0A9P4PK27_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_472203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK27"/>
    <dbReference type="OrthoDB" id="5131270at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="292" mass="32869" checksum="0CF673D02150EA68" modified="2023-09-13" version="1">MLIPVAHLVSFSDSQQPASSTPTNQHFLQVPNKKTSMLTALFLLTLPLASPWTIPVHPDLSYPPRWTAAPGDRYMRHNGTSVLHSLLNSCLNSRVPQNATRSTFHVSNGRAIFDLVNATLGNPTNESFHVDVYLPHLYYKYVDGPGGSEYNEGVKGKYQMGRTMWRYHYWQSFPEKGRCYLPLNMTEMVVDENENILRSEDLVGLNATLMFQLKDLRHYSVFEQVDQCAYVTLTDEDVQPAEDVVPCDGYNPVSDLARLSRPSSPKNSGARLEKIGLVMLTEMIAAVLWSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK34</accession>
    <name>A0A9P4PK34_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_281984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCNDBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK34"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="8">
        <location>
            <begin position="52"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like C-terminal" evidence="9">
        <location>
            <begin position="229"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2444748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="369" mass="39106" checksum="B3C5644E50BAC821" modified="2023-09-13" version="1">MAPKPASLRALLDITSTTLTLLTHFQSSLSPASTTDASIPPPPNPLQALKACTALLKSHTTTLSLLLLTPPLTPSAIITKIGDVSSGPLTGLVGAAVAEGGLGGLMQGEVKVQVRRLLGAWGEVVGCVARLAEKRKKLEESDGAAKAKGKDVGLTEGERQDVLAATGVVWEACDALVKLCDGGIAGLVVRKAEEWRSVLLDAVEELKEWGEDVDEEDDEAEGSDGEFGDEDEMFGAANKLGKGDKELKEVLDKGVKKLKMVGVLYQALIKRRLKTFPGSAPAGAANGEAQKDPMATLEELMKLMKSIPEQVDDLASAFYDLDEDEAKTMLDKCCGEAKSAASLVKQSWTGTDDEFTAWSTKWEDALNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK48</accession>
    <name>A0A9P4PK48_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hsp70 family chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_484150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK48"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="613" mass="68914" checksum="0103A59779F1AC72" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKB4</accession>
    <name>A0A9P4PKB4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_443207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKB4"/>
    <dbReference type="OrthoDB" id="10537125at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040118365" evidence="1">
        <location>
            <begin position="23"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="244" mass="26758" checksum="F9A4C55BF18A9A54" modified="2023-09-13" version="1">MPRQSHALSLSLSLSLSPSLSCTNPDRSARITPDRHAAASPGYLIDLPHRHHDDHSIRPRIETHRAAPLPLWKSTSGQFHRTITEDGKHVEQSANRHGIFVARPLLDSPLASWFPDDDTWAEGVSAPAGFFASSVSIRECWHLPFVIVAMDALISFLCSCRTSHLSIGFVSGDSCEALSSLIRDSPFLFLSQTLWIPFAWPNGTASAMPPCCGVQGSRPGPSLLHRGSRRIMARNFNRPALTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLA1</accession>
    <name>A0A9P4PLA1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_463677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLA1"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000019">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF39">
        <property type="entry name" value="PROTEIN QUTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="334" mass="36459" checksum="9012C51ED0EC2874" modified="2023-09-13" version="1">MASISRADLDEIYAFAVQLGKDAGRMLMAAAQARMGDAGSSTQKAHVQKLNAVDLVTSTDEDVEAYLKNAIAARFPAHKFVGEESYSKGASRDYLIDDAPTWCVDPLDGTVNYIHLCPMFCVSIAFIHRSRPLVGVIYAPFLNHFFAACEGRGAWLNDTIPLPLVRNPVPPMPEKAPNGCVFSCEWGKDRRDSPDGNMQRKVESFANMAAEVGGRQGRGGMVHGVRSLGSATLDLAYVAMGSFDIWWEGGCWEWDVAAGIAILLEAGGLVTTANPPHPDEDTAPIEEVRLGSRLYLAIRPAGDSTTETGRQSQERTVREVWKRVRNLDYNRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLA3</accession>
    <name>A0A9P4PLA3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_511677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLA3"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="181"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="360"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="460" mass="51055" checksum="3ECC2E751FBE2BC2" modified="2023-09-13" version="1">MPDKSINTDTEGYDYILVGVGSASCWITSRLSQLLPDHQSLVLEAGEHRRDYPKVQTPGLSSTLQSNPLYDWQYASAPEPGLNNRCAINSHSVWSSQGMQDCYKRWQVESSEPGVNDDVRSLDHAFEELGHPTEATEFSESSPGAVTVTNAVDSSNGERSHAAISFLELYAIALAAAGGLNSTGVRYTYHREELVVTAGEIILCAAVFGSPAILERSGIGSKKFLAAANVPILYELPRVGKNLQDHLNCSLSCETQDHIHTCNEAVRNHEESKAALMEYERSRTGRMSEAPYETQELTESVKHWVEDETNPSLRAQYAVIQKTVESPIEATATTFILLSQRSQDTEFFPKGTPPFVDGNYPEIRFNYLTHPLDMEILARHLGLIERLFQKPTFTAIAKPNGRRLPRSFPYPISSLEDVKAILPINAATNYHPSSTCSMMRKDLGGVVDERLRMIYSEAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM16</accession>
    <name>A0A9P4PM16_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SURF4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_429220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM16"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="304" mass="34257" checksum="50926A0B6A0EC37F" modified="2023-09-13" version="1">MAQIRGTAGYHLGNQSPFGNGGRSDSTTNDPSPLDQLREQTNKIEDFLDTLSEPVKPYLPAIGRFLIVVTFLEDALRIITQWTDQLTYLHDYRHIPSGLTHLFLVVNVIAMTVCSIMIIARKHSDYGVFGLIGVVVLQGLGYGLVFDLNFFLRNLSVMGGLLMVLSDSWVRKKFAPAGLPTLDEKDRKMYFQLAGRVLLIFLFVGFVFRGDWSFWRICVSLLGFVACVMVVVGFKAKFSAIMLVVILSIFNLLVNNFWTLHPHHPHKDFAKYDFFQILSIVGGLLLLVNMGPGQFSVDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMC2</accession>
    <name>A0A9P4PMC2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_472100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMC2"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="9">
        <location>
            <begin position="265"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2446642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="403" mass="45624" checksum="37ABBA084C1CD99F" modified="2023-09-13" version="1">MTSSTMKDVGFVHGLQGNAFGTWAQDLEPQQQERQDPPRTWNAFRKLLKGRGRRQDATVQPRGGKESGHNMNGPRQTFSPESLLPTHCARARISVYGYDTRITRFGNDHQDDLDIQDIVKSTAAIVFMGTPHRGSEDMAAWGEKGRKIASALFIDSLENGDLERCHHNFIRLWAREKFRIRTFQEGRALSGVRLGPLNDKTIWACVASRIWMTEFQKVGAELESIYKLICAVVNINWYDYYGVILSLCFPCMDTRGRAIRQPLANSCQWISELEALKSWFDGDDDSGLLWIKDKPGSGKSTLLKHTTSYLSTHRRTTEDVIAVFYFDTAGSDRLQKTAKGLSYSFVEDMVPSSQYGSRESLVLEADRTAPYDREVGSPDSSGPHTHNEITIALKERIKEFELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PML6</accession>
    <name>A0A9P4PML6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_431078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PML6"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000549">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="663" mass="72243" checksum="0DFADDC0BEBF317B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNH1</accession>
    <name>A0A9P4PNH1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1709-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_517916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13278">
        <property type="entry name" value="PH_Bud4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000311">
        <property type="entry name" value="GTP binding protein (Bud4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1244"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="667"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="932"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1298"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1380"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1301"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1418"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1447"/>
            <end position="1480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1480" mass="163842" checksum="531A7DA8D5BE92B5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNS8</accession>
    <name>A0A9P4PNS8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_355325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNS8"/>
    <dbReference type="OrthoDB" id="5372703at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="295"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="476" mass="52390" checksum="0D4A20D75B5DD5F4" modified="2023-09-13" version="1">MKRLVSNVNAVQQSRCPGRISKRRKTGHVNPETRRTSPPPSNPSNSTLQRSYVSSQPFALTEEALENTQQPVSDERAPSIQHWLETCPADSDPDMMPAPPTPRSASVSSSRGRRSSKHSARASRTPSPSKRTTPQTYRAQNMSYAGILIDDLIELPQEIERRVRHILEAETLEDVIGTTEHESQLAPHIKRFLDQSRHNARSCSLEGDWKASLFGLIGDLAQGNVQCHTSEKLWNADLKPSPPGVAQPDDESGASTPRFPQPQFALSDIDSQSASGFPGPVPSLQPYTPSISYTTSTEAADPFYISTPKPDIVVGLEDRAFAPTHRVRLAKHQSFRSILSDPHTAAMGLRFPFLIAETKGLSLNGGLVAAQNQAAIGAACMLKILDDLENQAVLPTAPTSPAAPQLCFSITTEGPVLELWVHFKLGEATHMQNIRVWRTTHQRDVRELVYCLARILKWANDDFIKTIQEKLDAVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNW0</accession>
    <name>A0A9P4PNW0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Aminomethyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_382247</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="4 12"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNW0"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="13">
        <location>
            <begin position="74"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="14">
        <location>
            <begin position="370"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2447432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="460" mass="49735" checksum="3145D05E3E06DA98" modified="2023-09-13" version="1">MASKRAAQILRPAVNAFRPSSVTLQHVANPHIAIRNLSLRAGRARKLTRVSTTAVRFASSATPTADGQLGRTGLYELHAKHGAKFVPFGGYEMPVQYTDLSIVDSHNWTRQKASLFDVGHMVQHDFSGPGAQAFLERLTPSSLSSLSENHSTLSTLLHPETGGIVDDTVIARLPDSFYVVTNAGCREKDLAYLSEQLETWRKENPDKTVEWKLRDNQGLVALQGPLAATILERVLSEQSASALKSLYFGQCLPGTIKGTDVEVLISRGGYTGEDGFEISIPPSATEAVTQFMLDSAKDELRLAGLGARDTLRLEAGMCLYGHDLDDTTTPVEAGLSWIIGKDRRANGGFHGDSVILQQLKKKSEGGGVTRRRVGLIIEGSPAREGAEIVDEAGEKIGNITSGCPSPTAKKNISMGYIKDGLHKSGTEVQVIVRGKKRKATVTKMPFIGSKYYKAPAPEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP04</accession>
    <name>A0A9P4PP04_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_508886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP04"/>
    <dbReference type="OrthoDB" id="3797705at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="452" mass="48868" checksum="41F9F3D32FCBCBD7" modified="2023-09-13" version="1">MPPWHSHRKSLYESVDVLPTLSTTVTVTRTVVRWVEPSSTLKRVASRARRPAQIDLPLASQVAGGGDVSLVEPAQTTSQPGNEAAASPTLSLTSSPALLEDTTLAHIAPEPGNPAYPLTLYDRLAEAPTTYTAIREYDYTPSISSNSMEGGDFELPDIPPSAQFALLAFLGAGVLWSVLVWVINLPLTRPKSNVQERAPREKGNTGTKVWWKCRWGRQHIPRQTPVDEPQTYAPLASGSSAGTTSSTEGIPTTATTSATPERAANAPIRLRKLASATKRQPPPSPSLPPWQSPTPPRNITPATHNHPQYNNSSTTPSSPANPFLPHSLQSRSSFEYLAAHHAFFSKPLSTPPLPQSSPHLPPYPSRSASPVSDLDALEAQSDSIVEPRRSRSTRSVMHIADGVEKTAGEFWTGGWIGVVEEGVNKAVDAVVRWTEEEDGEEGLLLPIGRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPB3</accession>
    <name>A0A9P4PPB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_429383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPB3"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2447765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="522" mass="56262" checksum="9EC0B277E0AD5217" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPG0</accession>
    <name>A0A9P4PPG0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_382825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPG0"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27657" checksum="6AA3454DC550AD4A" modified="2023-09-13" version="1">MKQHKEVLDEEEEAFLSSHHEAPMPEPCRTRWRAKDYIRLFIELAMACTIAALLVRQSTSASGCSPIRRTPMPQLSRKLYTFQSNPRYTPEDMFTNKSTTLHTLHNWIELSSAGRGYVVAPSSGNYDLPKPYTIAIDRHNNGPGYMISVFHQLHCLSYLAVHFQEGYDGVKLQDEIAHHSVHCFNYLRQGITCNADTTLEGQTDAGPGEGSEHECVDYDALLEWANEKAGMRWRDGLLPEEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ45</accession>
    <name>A0A9P4PQ45_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_440615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ45"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="145" mass="15980" checksum="ECBE05B1AB176ED1" modified="2023-09-13" version="1">MAPSRALLVVAQLRPSPRLLPATRRTISSCAQAHRSRLSPALLSGPTRAFPALSSRRAYATAAPEPPDYLNEAELHIFNKIKAELQPVKLEVQDISGGCGSMYALQIESERFNGLSVIKQHKMVNEVLKEEIKGWHGVQLRTKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ77</accession>
    <name>A0A9P4PQ77_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ77"/>
    <dbReference type="OrthoDB" id="3755722at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040394838" evidence="1">
        <location>
            <begin position="19"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="174" mass="18334" checksum="29E39CF2EDAA88ED" modified="2023-09-13" version="1">MNPPTLLLALATASTALAAFVPIHGCEWVPSTTAVTDFVFLSNASNPSAPSSISWKAPAVAATCKTENATWLPISGHQYSVPCVPPENGLIQDILRVSGDGTTALIMFRAYAQCAASIYAFHYEAVFPLDCTEGSGGFTRCEAKGDVAANCTAEEYLPPIRPPPPPCYGCGHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQK1</accession>
    <name>A0A9P4PQK1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_382471</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQK1"/>
    <dbReference type="OrthoDB" id="1928777at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000333">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="148"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="16">
        <location>
            <begin position="987"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="546"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="885"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="824"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="919"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2447553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115058" checksum="E7C2471CAF8C200A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR57</accession>
    <name>A0A9P4PR57_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M43 pregnancy-associated plasma-A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_217803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR57"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="9">
        <location>
            <begin position="75"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2448682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="224" mass="24403" checksum="3A6E31C1FCDF9C8C" modified="2023-09-13" version="1">MYWHILVSKNPEGEDWGPSIQSQVNFLNAHFELWGYHLNLKFTTYVIGAEWASDIDVDKENKMRTLHQGDYQTLNIYLVEGAGGGVCSLPDGSGQPISQELLDFDGCFVPLEVGRSATSGTLAHEIGHWFGLLHTFQGGCDGDGDYCDDTAPQNEPSHGALATPGDLGSCPAADQCGKGPVNVKNFMDYTDCSQEFTPCQGGRMNVAWQLRAGRALAEGVQVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR91</accession>
    <name>A0A9P4PR91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_219221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR91"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="67" mass="7323" checksum="E5511F79946AFD46" modified="2023-09-13" version="1">MPNVKSVAVAITTMSLFARSGPRPKSNHLTRTAHYPLYLQHVFGNTATDPTPSPKDPMDTHPTTALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRC1</accession>
    <name>A0A9P4PRC1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_380105</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRC1"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF9">
        <property type="entry name" value="ENDOPOLYGALACTURONASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040418065" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2449874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="372" mass="39055" checksum="01F4F52646956E60" modified="2023-09-13" version="1" fragment="single">MKMRSQVLTVAAIATFADRAVAAADSSCTVTQYAGVPAAVANCTAITLSDILVPGGQTLDLTKLKKGTTVTFAGKTSFEYFDGNIDLIKVAGTDITITAEPNAVIDGNGQAWWDGLGSNGGISKPNHFITVSKANGASTIKNLYIQNWPVHCFSISNSNGLSIYNITLNNAAGDAPNSRSNGLAAAHNSDGFDISSSNNLTLRDSWVRNQDDCVAVTSGDSITVRSMYCDGGHGLSIGSVGGKSNNNVTNILFENSKVLNNQNGARIKSNAETTGYIAGITYRNIELSNITNYGIDIQQDYLNGGPTGQPTNGVIIKNVTLENIHGTVAGKAKGYYILCGDSSCSDFTFNNISITGGKNSSCNFHPDGNFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRR6</accession>
    <name>A0A9P4PRR6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_408053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRR6"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27325" checksum="1F6B07341392AC3C" modified="2023-09-13" version="1">MPSHVILYDLPSKQGTSWSLNPWKTRIILNYKSIPYITQWVEYPDLAPTLSSLGIPPNPSDQNPVRYSSPAITHSNSTHEMDSWAIAHTIEQLHPTPSLHLNDPVNVQVRDLVTSLSNPLRPFIIPKVPAILNPRSASYFLETREVRFGKPLSRVFAEDATERCWEEAGFAATELAKLLKVDASGPFFLGKKVSYADFILVAYFKFLERVDREAYERVVGLDEGFKRVYEACKDWLDMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS48</accession>
    <name>A0A9P4PS48_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4267 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_427611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS48"/>
    <dbReference type="OrthoDB" id="4160064at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="20618" checksum="1519FB228B0A7751" modified="2023-09-13" version="1">MTSGQTYKLVTNTCILLSPRPTTNYCNESSRTPTTNMSQPIIKSSPIDPLIGAKATSNQDPKPIPSSSALVINTLALGRIGLGIASFVAPTLTFSLFKIAIPANMTPLARMFGGRELVIGEWTWMINHEDRNVGDGGRRELKRTMRLNTVVDALDFAAVGYGVATGTLGRLPAGLLAGGALTCVAMDLWGLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSA9</accession>
    <name>A0A9P4PSA9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_508628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSA9"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="219" mass="23728" checksum="B7EA852F27173771" modified="2023-09-13" version="1">MSHPYPHDATTWTESLLHHEQDHANPTPQSSTTPATAHQDNPLSTKLCIPSAPTAEAPDTPATTTTPTSPQTTHTLQALRQDTALFYRLHVFIHDLRAFRSNASSRARLDAVLAPDYIGRPYFSDAQAAQLRSTVVDEETGETLGQRLDCLFTEKLAKKLEKGGAWRVCAAHDLAPVFEGVVGVRPGELGRDKGFVGLVRKGGLDAVGEGGVWKGVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSS6</accession>
    <name>A0A9P4PSS6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_517224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSS6"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="722" mass="80833" checksum="6DE47C234F1B582E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT56</accession>
    <name>A0A9P4PT56_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_509229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT56"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="340" mass="37774" checksum="B967445149ABDC51" modified="2023-09-13" version="1">MAASEPQKKFHYWRTHLWSQWCFTPPYPTTQWTGKTVVVTGANIGLGREAARHFTSLGAEKVIIAARNLDAAQEAKASIETSTQCGPSVLECWPLDLCSYDSTKAFAARCTTLPRLDCLLENAGVSKYRFYKTDGALDELQITTNVVSTFLLAFLLLPKLKETALKYDTQPHLTIVTSELHHQTTIPERKALRKGIHSSLLDALNDPRTSSRSGRYPTSKLLQVLLLRELSSTLGRDYPVVLNCVNPGFCHSALTRDFAPIAYIGKIAMRARSTEVGSRTLVHAASAGRESFGEYLSNCQVALVGNFVRTSEGKEVQEMVWREVLGRLEEIEPGISKNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTA5</accession>
    <name>A0A9P4PTA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_200115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTA5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="95" mass="10593" checksum="F0A91213B222BDBA" modified="2023-09-13" version="1">MSNLYTEMVHPSLECPACRPTSTATPRIPGTALRRRPRMPHPDQHHQTGPCVTSLPPPLHFCTSSPRFLRRTGLVVSTMTKKKSREHRGIGNPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTC7</accession>
    <name>A0A9P4PTC7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_503796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTC7"/>
    <dbReference type="OrthoDB" id="10508974at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35135" checksum="6CA42BFA24282641" modified="2023-09-13" version="1">MFLFMIPQQPEGMAPLPMTFRKAPIPEETPEIIAPKPEKEYLFYEIAMPGSSTHSLLNPDDDDNPDTASNMYAASVASSLDLTEVEPRTFMDIVDDAIPVRTKYRRPKPPPRNGSPDSFHDLRFGAEVLPNRHHRRHRSHSQVPVSFTADREPCRTKPAADPTQVTWSYDNDDYGRYRRDRLMSDVLEAQALRRENQRRRSHSTSALSSANTWEVSPAQIGMDKSGFSEIGVLSPEEMWPDLVGTSDTQSGGKPEDTVTDRPKKGIVSRFKKFIQPHGKNDKVPGGEKDDKKNPRTGMNMLSATMGYGMGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU05</accession>
    <name>A0A9P4PU05_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_377210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU05"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2450255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="196" mass="21893" checksum="812129834DDB0503" modified="2023-09-13" version="1" fragment="single">MLLDEDPASLIAQCTSHFKLDSDRSSLLRISDSLATLSSFRQQHTSSLQSTLTRLNRTHQTLASNHNHTLSQHNPTTHAAEILRLDTEKFKIAKQASDLEMEGERLEGELGRLGGVLGELEAEGVEGGEREKGPEEDATVLKLKVYRSLGIDVEADPTGQYNKAVIRNAAKGDVHVVNIDPKFSRNFYTNYFWRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUL5</accession>
    <name>A0A9P4PUL5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_503135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUL5"/>
    <dbReference type="OrthoDB" id="3792500at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37972" checksum="E7A747DDA5ABD357" modified="2023-09-13" version="1" fragment="single">MHKKLHPARILRRILNGDATSHTHLPQTVADLEALARARNNRCTCDTCTPRARKKSNCVPWPHFTPDLPSRLTTNRHGNTVFAPPKLSSRAARPAQGPLLARSMISYFDQPPSHLNDAQLAARASLIAWRDRRMSALLTPYAHPNGRLLVPAPEMQSLWEGLNTLFFGGRIPGIRFRWTEDKHGVLGRSAFSFGGSPVISMHPTRTSRDFGDYAVLDFLSTLVHEAVHAFLQFYACRWYHVWDGEYTAGGHGRVFQMLAKKLEEAVPRLLGVPVRLGRFESLLGDLGVREGKEGRLRGRVPSVHDLELWRFEDVDRDVQNADVRRLVEKTLAEWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV95</accession>
    <name>A0A9P4PV95_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_351305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV95"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="384"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="733"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="936" mass="103101" checksum="57BAAAA6E4BC3A44" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVY5</accession>
    <name>A0A9P4PVY5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_492537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVY5"/>
    <dbReference type="OrthoDB" id="3783019at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="231" mass="25942" checksum="4AD808F4A7E04C94" modified="2023-09-13" version="1" fragment="single">MADEWSPFKMWSLTAVRDWASANFPDAFAALPGIDDVEFVELDDDMMDISPFRLPTNTPKKLLCIGIWDGFPCDPQDRVFAFPHGPNHSQVGYIREDSHVTPKRYRRLGQAEMKKVDVEEPLCYIADGTERATLTRLGTLVLFYFVAAGHILQFRGDESFTREFEKACLYIEHGWPKTEGLLPGLDQPSSQSQIYSADAGSDHDLPETESVLAKLEELGEFRSDDAMGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXE4</accession>
    <name>A0A9P4PXE4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_426413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXE4"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="519"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2452007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="779" mass="83425" checksum="9F0DF30639EFE6DA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXF3</accession>
    <name>A0A9P4PXF3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_516804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXF3"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040134606" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="33573" checksum="3BDC79A559BFA1AE" modified="2023-09-13" version="1">MRLLSSLTLCSSLAPAVLAYGSSTCYYANGTEITNTEFRQCSDGVTTICCALGRENTPGNETNEMGWTQDECLPNGLCQNRLRIGGVAQTYWWVEYCTNPDPTSSECLDVCRHTRDSAGGSIMTPCGVSRDGSYNALDDTRDVTRWCCGESDACCTNNIGVVELPRKFTGNAITSSASSSSSTPTASSTTSSQASLTSSPAPTDTKTPEAGNNGLSTGVKTGIGIGAAVGVIAILLAAFFGRKAYGYRKLVKQREAEDKYALQPPLYGHEQNHANTNYAPSELYATTTPAEMPTSEPPRPPRELPGSHDRYDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXN6</accession>
    <name>A0A9P4PXN6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_503995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXN6"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040118771" evidence="8">
        <location>
            <begin position="17"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="248" mass="26559" checksum="96FC40C8A0566B2E" modified="2023-09-13" version="1">MKIIVWVACLLSSAAAYPLVQSRQTEDHAWRAPTATDRRAPCPMLNTLANHGYLPRDGSDISMDVLVAGLKAGVNLGADATKLVGAAALKGSTTGNASTFHLTDLNKHGLIEHDGSLSRADTSSSDNHSFNATIWAQTASHFTESTIGLGTAAKARKDRLTAAKAENPTFNMTDGDVQASLIETALYLNVMSNETGVTAVTAWVQKLFQQERLPIEEGWKRPKGEISVATILGLKVLMSSRQVRTSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZ77</accession>
    <name>A0A9P4PZ77_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P171DRAFT_426342</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZ77"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001377">
        <property type="entry name" value="PRK00278.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="259"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="579"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2451908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="770" mass="82961" checksum="06415708D7B733D5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5R1</accession>
    <name>A0A9P4U5R1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_158628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5R1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="138" mass="15699" checksum="A1E379A38789BD71" modified="2023-09-13" version="1">MWRTKHLALSRRWWYCDTSVQCDESSGYGEVDKLCLTVQPNKYTTNARCWIRTAPPSPDISIPSTHLPVSTTPITPPNLLSTSHPKRRPSYTHIHPLTPDHHFPRNIPIPSLPPRPSYRGRSVFASTSAERGDRTETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6B5</accession>
    <name>A0A9P4U6B5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_457725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6B5"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2439954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="549" mass="61031" checksum="87F9AC0A1E096736" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6P4</accession>
    <name>A0A9P4U6P4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_489077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6P4"/>
    <dbReference type="OrthoDB" id="5325022at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
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        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
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        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34666" checksum="6B2047F3D9B19519" modified="2023-09-13" version="1">MADGQHPSLVPRWTVAVHAVQILFAIVILGFDAYGIKYIAYNALIFSLVVCLCTMAVGAYLIASQTIFPKMYNVYIALAVHVWLLIFWVVDLGLVANLAAMWGRGDYCFTTSYGFGSTYCYLKRDLIKRDDYTTFGAYYGVLTAGAVFAAVQLVTWALTGILLILAWNKQRVAGTTTTHHSGPPQYQNNGQSVPMEKYDQPSTSAPTPGPQYGVPQPQYASPQPQYAQPAQPHFTGAPYAQDPVQRQDTVSPVSHAGGYAQGHNHNHNPSVSGVSSPQHTGQPAYPPTPQQQAYPQNAAEVHTDPYNPNVPELPNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6P9</accession>
    <name>A0A9P4U6P9_9PLEO</name>
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        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_467108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
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    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
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    </dbReference>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
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            <end position="830"/>
        </location>
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            <end position="10"/>
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            <end position="220"/>
        </location>
    </feature>
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            <end position="230"/>
        </location>
    </feature>
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            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1241" mass="136368" checksum="180ADAD78F23EE6A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U926</accession>
    <name>A0A9P4U926_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_446613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U926"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="370" mass="41930" checksum="CEA3662756E07685" modified="2023-09-13" version="1">MICGLVVDGDGQRLLTPVLLSALHADDQKRFHTTNAFCSPTDAYSPDCEAYGRPPLAHQRPERAMSSPPKGEAAQRLFLERTTFTSLDFRILLRQPHQRCLLGPLEALAVDFSTCDNPRQPQLTQREHKQRRPAARRRRDERPHSISTTCYAAHTHNDNANPRASAYATWGTTSGEVQETSAPAPSIHRYPDAVLYGRARTLSHNSELCTSGLPQDQGSRASDTNWHARRVGRTFMCRQLHPGGPNVARKHREETDRRSPRRALARVAERGSETPQAPTHHRSKSPYQNWGANQVRWNLRTRITPLQSHLSSSGDRLHTLTWEERGTIQIGKCDPRIQLEELMPMIEAQGHPHRHKEHPYGMAHLSTEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U959</accession>
    <name>A0A9P4U959_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_55554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U959"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="677" mass="75088" checksum="23F19D6779481E46" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9L6</accession>
    <name>A0A9P4U9L6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_91801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9L6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="151" mass="17768" checksum="48AD675711CDCB8F" modified="2023-09-13" version="1">MGCWSRTTRRSRAAKPARTNASYKQNFRRPAALIRPLPAPDLRPLCFGSPVLNTFRTASKPPSIDSIPGTHVLGRKELSHNGRHRHVSRRLAAHQASQLRYPGTRCHRRFRHRRCRRHPDHRPADLEEDGRPQGWRRLKIPRWRWWNDEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9L8</accession>
    <name>A0A9P4U9L8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cystathionine beta-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_417048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9L8"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18224" checksum="03C5731A67912CBC" modified="2023-09-13" version="1">MSTDAPAAASSTANDDYQSLWANKYRGATVEDLEPPPALSCRPTDPISHALMSGLERDYTHLTVTSENRALLGYISIPRLQQLLKEGKVKDNDPVEAAMQKFRRRGTKYKVISLETPLEELEEFFNGGVDGSGKQDFAVVTDGSRKFVLGVATKEDLESFVKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9S7</accession>
    <name>A0A9P4U9S7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF962-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_392046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9S7"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="197" mass="21619" checksum="64B500198C6EBDFF" modified="2023-09-13" version="1">MSLNLEKQLRFYGAYHNNPVNISIHIVCVPLILFASVVLLTNTPAIPLPSWLSIPHLPLNVASGVLVLYTTVYMLMEPVAGAMLAPILIGVTAYGNHLTSTYGATANKWAGGVFFASWIAQFIGHGKFEGRAPALLDNIVQAFLLAPFFVWFEILFTLGYRPDLKKRVDKAVEEDIRKFREKKGQSANGDANGTKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9X7</accession>
    <name>A0A9P4U9X7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_70190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9X7"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="402"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2442595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="623" mass="68486" checksum="FB592D6FECC5B627" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAD8</accession>
    <name>A0A9P4UAD8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAD8"/>
    <dbReference type="OrthoDB" id="10466872at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="422" mass="48358" checksum="DFC400EE0427E5CA" modified="2023-09-13" version="1">MKTKQLLIELIKLAREEASEQLKDVWNLPAPTMPKPQDPYLQLDLRDEASGGRFLNEPDEASHLNRDNREGEYKFLDESNLQLFMRIDGMPTAKRALLYVMRKKHEISDTADVWMTFVGEIDEDLGPVQPHRIRLQTILEPLKFWDTLKYRYPDFDNLLEDTEDDVTEDCCQPFWQFAFAAIRTSPHMFKPGYTTQHKRKKIQRFSWARMLVLLFLPEVELMKELFHAGLAPKEAPSGWHEQARDKMKTILMKHARGNLRAAIQNGWEDLCIEVDEVFVENSLYANYAVPPPPLSAHGQDEQDPRSPQALGSDVQNNQSNSGDDILSMALSETLGAMSVSDEENRKDARSKKRKDLLDSSREMSAPKTPSQAPSHQCQSSVLQPRGKKRDRNNIESVDGHTDSGEDIPKPKKRPNCRPGPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAG0</accession>
    <name>A0A9P4UAG0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_364587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAG0"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2442208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="277" mass="30920" checksum="36CF3B2A1E1F2463" modified="2023-09-13" version="1">MGQPLVQTIHRDPALFWWILLPITVVMVLTGVLRHYAMILLQTAPKKQELPKIRQQRALVRGINLRANANVLSPASFQARKAYMVSAFQEGKFLAEPEARGKPRPNPMSDPAAMEGMMGMMKGNMAMMIPQTLIMGWINAFFSGFGSPLRRPGFSLSLANRCCPTVKLPFPLTPQFKSMLQSGVGTRDLDVRWVSSLSWYFLTLFGLQPVYNFILGSNNSANNVTQQMAMANPGAGLMGPEQDPDKLFLNEAENLEVLEHRWILDGIEERLIAKMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAG5</accession>
    <name>A0A9P4UAG5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_497004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAG5"/>
    <dbReference type="OrthoDB" id="4072826at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="242" mass="26986" checksum="3CEABA487FF28F61" modified="2023-09-13" version="1">MEGGVAEVPDAHQNQTLTNTRITMAEEASPGRKVFRGSKRDGKDSPVVNTTQPRGGWHQEMVYTSNDGECSFQPLIIALKAGDGSRDDDSPGYFLLMRDAAWATATMEAMKTEDEARSWYTGTNGEQARVGLLIKHPDGQEELVGEAWVYRLAGVWPEVYCVLKGGKYGKDSCQRKGYGTKFMTAFLEKWWSLPRETGPIKVQPDYVDEQERNMSEVPERLCANICPGVASHKPWYLSSKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAK0</accession>
    <name>A0A9P4UAK0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_363772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAK0"/>
    <dbReference type="OrthoDB" id="3777101at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="229" mass="26666" checksum="6FCF72231B583292" modified="2023-09-13" version="1">MDDLQLDELYWKTENDTAFHAVSYKEKQSNDKQTRNAELDDDLRLPAFFTSNCTKVVYCLLPQVREVLGDDPEFDKASWSREYIDPELILFDVDENGNQNKNPLPFLAHDFITIKSKDNQQFVLDVSGDQFGLKEWLYTKKDYWKLLLDGQAPEITCEATKLHKVESEDTRNSALQSAVEQALEEVKADWAREYIFWKDLHLLPEWKRSQLQKSIAAKVRVKVVATLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAW7</accession>
    <name>A0A9P4UAW7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_487724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAW7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="254" mass="28515" checksum="A89E5FEABC990031" modified="2023-09-13" version="1">MAFTHTSLASAIPLDQHRIAAFDNSVESNGDVATLDMITYLFDCEPAAFDGMISIIHTHQIGLAPFQLIQAECDLPEEVTNAKMAAFNTITSGADGIALESSNMIGVVFEGLWNHVAKSRLNKEGQHNDLSNSPKKRVRLFGREDTDERRKKRIRTDENTLVLSKEHAPVSYDQITIAVYNACDQELADPIVLMHARCLMDGAKDMKLILQRNDWCGVFIHKSIVYAKFDKEIRDAWRHLCKAWGIIGLKDIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC29</accession>
    <name>A0A9P4UC29_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_412612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC29"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000054">
        <property type="entry name" value="Actin-like ATPase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000139">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000025">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="748" mass="85018" checksum="B6626FD3D3578306" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC60</accession>
    <name>A0A9P4UC60_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_432095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC60"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="72" mass="7975" checksum="AED4D9A40609A800" modified="2023-09-13" version="1">MPACHSLPDALLAPGSWLLSQRSATGLKAFAHEPLNTWSKRADGVRAAANCARRRLCRLFFWSPLHQHGPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC63</accession>
    <name>A0A9P4UC63_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AICARFT/IMPCHase bienzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_432969</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC63"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2443797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="598" mass="65666" checksum="D50CDEFB3E68DFC1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC87</accession>
    <name>A0A9P4UC87_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_45841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC87"/>
    <dbReference type="OrthoDB" id="3791801at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="281" mass="31782" checksum="40A263B401633961" modified="2023-09-13" version="1">MLPEQIKLWKLPSLAAISSLFVHVRTHEQAKASHEAFRYLLTNTPRLDDLSVCRDFTENFPLTDWHASLASVLPLRLDVSSPLVLKHLELGDLRLGESSRALLHEIDISRLEGLHIHDCVEVTPFLSALSSLFSRAKPSLRRLNVSSNERLPILGALDAFLQTWRGLRTIVICMPLQNLVPKEGIMHHTDTLRLLLLGDVADRYQEPYNLNVMDILKKCSRLQEVAINLGPYDLGHWLDTAPSYHLEKKDDNVLPFSREAVMESLETQRSQDATDVEPSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCE2</accession>
    <name>A0A9P4UCE2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_410998</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCE2"/>
    <dbReference type="OrthoDB" id="2130367at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF9">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040235598" description="rhamnogalacturonan endolyase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="13">
        <location>
            <begin position="382"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="12">
        <location>
            <begin position="472"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2446629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="692" mass="76879" checksum="C83A3A1004B7E01A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCY9</accession>
    <name>A0A9P4UCY9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_386545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCY9"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2445746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="230" mass="25848" checksum="85C7A165D1A571F6" modified="2023-09-13" version="1">MASTRPLTMLARTRPAATLLRPSVFAAGRLPSPATVALFSTTFPRAATPAGPPPPGFRLPPRKKWDEGESALDRAGKYFLLVEMFRGMYILLEQFFRPPYTIMYPFEKGPISPRFRGEHALRRYPTGEERCIACKLCEAICPAQAITIEAEERMDGSRRTTRYDIDMTKCIYCGLCQESCPVDAIVESPNAEYATETREELLYNKEKLLANGDKWEPEIAAAARADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD19</accession>
    <name>A0A9P4UD19_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_274663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD19"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="262" mass="30003" checksum="A5B5D68B2B61D896" modified="2023-09-13" version="1">MPRQAHGRQELLEGNRHLKKTAKTGKRVEWSRRPTMENPLSRDQSLQRERQRLQSCVAQAMLTPTATTAPPPVYLRKRSRGTAILCRVGVQGKVLRAGGRNSSTRYKESCHWTSSMGSNRAANRRRRTRSHLVCMRRSRTSATRTQTSDRQCYFLMSRKTSTAFCMATDKSDISRSLVSIKSHFRTTCPGGLVCTVVYSIVDRNTYHATWQRHSMCHVDKTPRVTWRHRPTKSRAHAHRATTNVWGFTENCEQLEVIAGVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE43</accession>
    <name>A0A9P4UE43_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE43"/>
    <dbReference type="OrthoDB" id="3915838at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040317353" evidence="1">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="160" mass="16918" checksum="26747E03FF75FA2B" modified="2023-09-13" version="1">MLHHFALLLVSFALAASISNAAAATVGKIRGVSDPIYHLYLQANLKNASTPVLGPESSAQTFAIGSTIQSQNTSAYLNIQTASTSYKPLVWGKSADTTAWGLEGDTIITVTGSSYGRQLNFLACKSADSGYYDLYLQTGGDVPSGKTCSNYQTIHLPCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFJ6</accession>
    <name>A0A9P4UFJ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CLU1</name>
        <name evidence="3" type="synonym">TIF31</name>
        <name evidence="6" type="ORF">P171DRAFT_405818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFJ6"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000002">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="5">
        <location>
            <begin position="320"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="885"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1194"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="885"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1225"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1244"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2450079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1264" mass="140241" checksum="58CB391EA77FDB89" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGM5</accession>
    <name>A0A9P4UGM5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_481458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGM5"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF7">
        <property type="entry name" value="PROTEIN STB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP000799764">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2450802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="359" mass="38596" checksum="9C865363ADD4BC3C" modified="2023-09-13" version="1">MALASVQKGLHNVSNNLNELMHAYIKHTASVLSGEDGALEGLQLSESAQHMIDEADFATKSVANLTKSLGGASTGDAGDADTGKSKKRKREKKIKDPNAPKRPLTAAFLFAQSARPIIRNDLENELPPGAKLEPNAINLEVNKRWNEMENVDKERWKASYRESMEKYNKEVAAYKASLGAAALVEEPAAEDDATENEADPAVLDSDVDSDDDDASNAELSPTKVPTPPPTFAANGKTPRPNKRQKTAAAPAVNGTHVAIAPAAGQTPVPPPATRIQTAVPPPSLAEATPVKKDKKKEKKVALTPAAKEPSPEENKKDKKKRATRGAAEAESEDKEKEKEKEKPTRKRDRSKRKSEGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4UJ31_9PLEO</name>
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        </submittedName>
    </protein>
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        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
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            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="191" mass="21035" checksum="7AB560A34C6C28E5" modified="2023-09-13" version="1">MNTPRERDSAWIWSEEHGDYYKAVYGPDGTILRYVWGRATIPPEPAGRLPQSSAPSHTAQSPRVSNPAPTTGAHPYATRPSGTPVGTQVPPTSQPYSDQQRDQYGRIIQPVHTHSDPPRDQYGRIIPTPQAQGYAHPTPSAQPTQYSQTQQPPQSTSPYTPGQYSTTGTGQYPAHGHYPSSRQYPPYDPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451267.1"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4UK62_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">P171DRAFT_16991</name>
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        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2452032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="163" mass="19200" checksum="CFC342A077B58880" modified="2023-09-13" version="1">MHSRATPCRDIRYHRHSCTKHKCPVSQAHRRFAQCCARRRPAFLLRWDLQDNNKPFLRATTHPWAILANQSRALRSFHATFAEDVLAGYLHQTRSMRLRRCASRLSRRLACCRCDAVPVRSRVRKQSRTAYRTKACHDRKKSETRRSLLLLYLKCTAKAPQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P2W1</accession>
    <name>A0A9P4P2W1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber evidence="19">3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Carboxypeptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Pheromone-processing carboxypeptidase kex1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">RAD52 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">P171DRAFT_400382</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6" evidence="19"/>
    <dbReference type="EMBL" id="MU001517">
        <property type="protein sequence ID" value="KAF2437304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P2W1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 25" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040110596" description="Pheromone-processing carboxypeptidase KEX1" evidence="25">
        <location>
            <begin position="31"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="580"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="845"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="905"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="940"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="972"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1000"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="1013"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="24">
        <location>
            <begin position="1156"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00040628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAF2437304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1216" mass="132573" checksum="420D72F4F9B72C46" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P658</accession>
    <name>A0A9P4P658_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_400243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P658"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="43"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2437463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="357" mass="41421" checksum="D03543CB2ED7E603" modified="2023-09-13" version="1">MALNSTAGSTSVARVYADVNANMPRAYWDYDSVNISWGVLENYEVVRKIGRGKYSEVFEGINIVNYQKCVIKVLKPVKKKKIKREIKILQNLSGGPNIVSLLDVVRDNQVSDGSDWVGDWSKTPSLIFEYVNNTDFRSLYPKFSDYDVRFYIFELLKALDYCHSKGIMHRDVKPHNVMIDHEKRKLRLIDWGLAEFYHAGTEYNVRVASRYFKGPELLVDYQEYDYSLDMWSLGAMFASMIFRREPFFHGNSNSDQLVKIAKVLGTEDLFDYLDKYDIELDAQYDDILSRYPKKPWHSFINADNQRFVSNDAIDFLDKLLRYDHQERLTAKEAMAHAYFAPVRNAAAQNHSASSSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P694</accession>
    <name>A0A9P4P694_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_477974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P694"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="297" mass="31520" checksum="32F4FDF4834B5A39" modified="2023-09-13" version="1">MSQNREHPGATTASPVRDAEEVDTDADSETTHHPSQIVVDREWLAALQATAEGQDTTSGKEEKYPPATPSRTSRLVVEQPEGGGGQSHPDAGSVPSNRSIQPSPGPGKGNPPSGSSSVMDATPGASPAAPAQLSRKRPRSPVDEQGDDADEDKLPHDKHHNDNADGEDNDNADGEEANQPPAKKQKMGIAPTYLIVQVRPNKAAEIMAGSAHSPVTIGIEKAWSVADGSDARMAELLGPTIKFDSAILQCSPQPQRWVYERASNFFRTGYNTIRARGAALSAQGELVNQKINNVFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6A9</accession>
    <name>A0A9P4P6A9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_178229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6A9"/>
    <dbReference type="OrthoDB" id="5414836at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="770" mass="78831" checksum="CB34DD83133BED7D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6Z4</accession>
    <name>A0A9P4P6Z4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_477953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6Z4"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="573" mass="64236" checksum="DE50109C8E271C4B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P859</accession>
    <name>A0A9P4P859_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1682-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_525580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P859"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2439002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="450" mass="50631" checksum="68D255359E1B1FCF" modified="2023-09-13" version="1">MADFVKGLFGGQQKVAQPHSGGDDDFADYAGAPEPSPALSFAATTGAASAVPTSTLGQVPYTAWYRVWERTSVDDFKLELYILPFILLVVAVHLWGTRRNRTKAHHWIKSHAPVLQQEFAQVGYTRPQAGADDVSAVGLAQATEKARQDAIKPENFLREKKPDEFASYATGRANVAFVDFKLTLAKRFNPLMRFGELAISLFFESMPVPVERMEATAYVFDGQEAKIAPAIARGAGEKVSNSTFDGFVFAVVHKDLMKRLREDRYDLSLTASKDHAKLPLWVTVMSESAEITDTILTPELIKAINDAGDDFEALVITDQSMDQPKKLDDTVPRKRINLSMKLRSASTPYDSALPLFQYFIRLPDFLASKAHFRPEALRRIKATREEQIAKIRKIDDEEKAEERKLASDKLKKEQRDAKLGRMTADEQRKYLDKERERDAKKRTKKQTVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8B9</accession>
    <name>A0A9P4P8B9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_447278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8B9"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000071">
        <property type="entry name" value="Conidial pigment biosynthesis oxidase Abr1/brown 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="130"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="258"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="493"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2440290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="670" mass="75840" checksum="79E910916C928221" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8K9</accession>
    <name>A0A9P4P8K9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Repressible acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_490894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8K9"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF14">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040376434" evidence="4">
        <location>
            <begin position="18"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="49"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="187"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="394"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="441" mass="48855" checksum="53EA3537137AA4F5" modified="2023-09-13" version="1">MLRSLAVSLSVANAAAAAYSFNPLEHLAGIAPYFEPEDPPLDPKPPQGCNVTRATYLVRHAAIYANDFDYEEYIEPFTDKLGNASVDWNKAGPLSFLGTWQTPISDEELEDLTKIGQLESYKLGVDVSLRYPSLKRPNKVWTSTAERTELSAKSFIDGLSRSNETERVSVPESKAEGADSLTPYKGCPKYSSSYGSEQSSKYKEKYTKPIIERFTNLAPGLNFTADDIVGMQQLCGYETVIHGSSKFCDLDLFTANDWLDFEYMNDIQYFYNAGYANPISGVLGFPWVNASAGLLLEDKAEQDIYVSFTHRELPPTVIVALGLFNNSMHSGTNNPNATMPLTTQNHNRVWKSSAILPFLTNIAVEKLSCDSFGYDAGDYFRVLVNQSPQQLPNCNDGPGESCSKATFKDFISSRGDEFGGFTEKCQPEYKNSTDALTIYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB12</accession>
    <name>A0A9P4PB12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB12"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="609" mass="67570" checksum="F15078A224E53945" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBB7</accession>
    <name>A0A9P4PBB7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_97981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBB7"/>
    <dbReference type="OrthoDB" id="4216928at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2440278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="399" mass="44547" checksum="86C40680ECF7EFD0" modified="2023-09-13" version="1">MLGYISSTRKKSCKQCVKAKRRCDLGYPCCKRCFSKSLDCAYPNASVREAEVVIRQRTPDLAPLDHAGDNELVGVQPVGCEFDPATLHVSTSDSNSSSSPESWNDIVGDKENGENGWTRQAQYWKRSQEPAVSRQMMPKIWAPSWLSEEQVLFMVSKVRGFVPTLAFSGANVFIHTALYKSHQPTAFQDSISLSALYLAKTKQNAPILIRSIDEKINGLVASSNGWSLQEHLAAVQALIVYQIIRLFDGDLGQAGAAARHNRLLELWAAHLWKRSFAEPVAFSKAWDAWVFYESLRRTVLMSVFMRGCWSALIQDGLCDQVPVLARLPLSKGDGYWNIGEDEFERRVAGVDGRDQLIAYGDFSLSWKLGDDVGALSEFQRLLLAGCKGHMDPRLFLDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC01</accession>
    <name>A0A9P4PC01_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_419508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC01"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="101"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="541" mass="58387" checksum="32205F122C66813C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC04</accession>
    <name>A0A9P4PC04_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_87910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC04"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="70" mass="7942" checksum="9A71B05AB25D864B" modified="2023-09-13" version="1">MPFVWKSSCTGRPHEATFTWLRHELQKELEPGVRTALPNRRGASTRTRSVLFITLVTASTAYIILTQLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDD1</accession>
    <name>A0A9P4PDD1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_446908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDD1"/>
    <dbReference type="OrthoDB" id="10400722at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="192" mass="20385" checksum="197B5720B6023AC2" modified="2023-09-13" version="1">MKFPKRQKRGSISAHTAATTPIGLSPALSAVRSIVEKTKPIEDPTQPKLRRKHKSANLYLDSVFDEELTEIDPATGHWVAIPFGRTRTLSAPMIILTPPSPEKADPLDEAGGVLARAASAMGTVQVPRSLSFPDLGWLASAAGRAIANALPYWRASEKLTGTTRTRSSKTLSIVAASSGNISPATCPSCDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEI7</accession>
    <name>A0A9P4PEI7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_434347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEI7"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF111">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_1G10100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2441708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="300" mass="32329" checksum="12E0922178F226AA" modified="2023-09-13" version="1">MSRPEHSRTFSTNLSSGSGSRALEGRVGIVTGSSRGIGAAIARNLASKGLNVVLNYTSDSSEKITQELAEELQSQHGVKTVIVQANMGDENGPKHIVEVAKNNLSHQKTGKFQIDVIINNAGVAGNNRIETINCEDFARQYNINVRGPLLLLQAALPYLPNDRSGRIVNLSSVSSSLGYVSQSVYGGTKAALEAMTRTWSRELAERATVNSVNPGPVATDMYGTNDESFINFNRPFLQSTPLATPRKEFEEDKTEYYESVGGRPAYSEEIAGVVGMLCLPEAAWTTGSVICANGGMRFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF37</accession>
    <name>A0A9P4PF37_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase-like protein 49 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_474638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF37"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="206"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2442183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="476" mass="53360" checksum="30612B178788B291" modified="2023-09-13" version="1">MPVSLARYAGHAAKRLCQAPRPTIPSSAPRLQPFARGLSTSRPRHYADVQHEQSAKLIPTDADFASPVDPESQGVLNSHSDEGSTSGRKIRHYTVNFGPQHPAAHGVLRLILELNGEEIVRADPHVGLLHRGTEKLIEYRTYLQALPYFDRLDYVSMMTNEQCFSLAVEKLLNIEVPERAKYIRTLFGEITRVKNHIMSVTTHAMDVGALTPFLWAFEEREKLMEFYERVSGARMHAAYVRPGGVSQDLPIGLLDDIYQWATQFGDRLDETEEMLTDNRIWIGRTQGVGVVSAADAINYSFTGPMLRGSGVPWDIRKSQPYDAYDKVEFDVPVGVNGDCYDRYLCRMEEFRQSLRIIVQCLNDMPAGPVKVEDYKIAPPPRAAMKENMEALIHHFLLYSKGYSVPPGETYSAIEAPKGEMGVFLVSDGSERPYRCKIRAPGFAHLACMDQISRGHLLADAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFN0</accession>
    <name>A0A9P4PFN0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFN0"/>
    <dbReference type="OrthoDB" id="10569029at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="694" mass="76951" checksum="78184A2965E76B13" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFY1</accession>
    <name>A0A9P4PFY1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_486043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFY1"/>
    <dbReference type="OrthoDB" id="3793005at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="890"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="487"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="923" mass="99680" checksum="5144EE020F72BBFC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG10</accession>
    <name>A0A9P4PG10_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Shwachman-Bodian-diamond syndrome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_47343</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG10"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="7">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="8">
        <location>
            <begin position="111"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="9">
        <location>
            <begin position="238"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2442663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="304" mass="33839" checksum="7FD0D79A06547D57" modified="2023-09-13" version="1">MPVGIKTPSNQIKLTNLALVRMKKGKKRFEVACYKNKIQDWKNKIETDIDNVIQLEGVFINVNKGQKASKADLEKAWPGMKNKEIVEDILEHGEYQVGEKERSAELERIKNEVINIVASKLVEPKSKRVYTTGLIEKSLDQLSQQTSVQQQGDKANGASAEDGEEKEKALPKWRGVVATKDAKSQANHAIKCLMAHQPIPVTRIQMRLRIVCPTAVTKQIVKSTGKPEKGKAVADEEQQAPKSVKDTILSYIEKVEADDTEGAEWEAVGLVEPGSYKNLNEFIETHTKGRGRVEVLDQSVGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGH0</accession>
    <name>A0A9P4PGH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_523274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGH0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF213">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040230034" evidence="3">
        <location>
            <begin position="17"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2442466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="679" mass="73370" checksum="7D0CB854CB79FF7B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI50</accession>
    <name>A0A9P4PI50_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_35491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI50"/>
    <dbReference type="OrthoDB" id="10613840at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="274" mass="31145" checksum="831A29966CB145BE" modified="2023-09-13" version="1">MANNDNPPPYNQGGFFNVPPWTWRGRFLGHDIPITKHSFYDACTLRGHEWDATVRGADEPAPGHGEVDVASLSPSAFAALEEDDDPPDTHLKHVAQQFFKSHIWTVDLARDPGTKVTMWAVLVNEDFKPDPQLSGAGLVSGFELRYSNKKVYRNNQYKLYVLLLLSEELGLGQVFPIVEDAVEMNKSDTVGWDETLQVNLTFKKMYNALIDYYHSERGQGIQTKFVCPLLWPNRGEDDERGEEDENMTTGSIQKEGLREVDITPWLQEGQKFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI88</accession>
    <name>A0A9P4PI88_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_34233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI88"/>
    <dbReference type="OrthoDB" id="3659804at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="238" mass="26087" checksum="4D21BF82B5D614B1" modified="2023-09-13" version="1">MAQANLGRLSGALVVLASRHSAGDFGFVPYCWTASERSIYLAAGKPPVTVHDLPAQMPALPVYAFARDVACDWRGPMLSGADFRRVNSWKAPRLVVFDGVAASAEHPDIAGPLFVVPTTDLCIHPAQLRLFEENVNVDKSKDERHARVPLLRELLHGGCNITDYVITGEGPAIYQEGSGSGWAKLWTLLDRFAGTSSFDYPDRTHRRLPQEFRVTVQQLHERSWEEANDAALGGAAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIL0</accession>
    <name>A0A9P4PIL0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Aspartyl proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_431133</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIL0"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05488">
        <property type="entry name" value="Proteinase_A_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033819">
        <property type="entry name" value="Saccharopepsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="85"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="116"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2445734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="397" mass="42890" checksum="0EAEDBF99D50CC36" modified="2023-09-13" version="1">MKTSTLLAAGSLMGAASAGVHKMKLKKVPLSEQLQHASFQEQAKALGQKYMGIKAESHVEQVFKAPYVADGTHPVPITNFLNAQYFSEVSLGTPPQDFKVILDTGSSNLWVPSSECNSIACYLHTKYDSSASSTYKKNGSSFEIRYGSGSLSGFVSQDTFQIGDLKVKNQDFAEATSEPGLAFAFGRFDGILGLGYDTISVNKIVPPFYNMLDQGLLDEPVFAFYLGDTNGGAESEAIFGGVNEDHYTGKITKLPLRRKAYWEVDLDAITFGDETAEMDNTGVILDTGTSLIALPSTIAELLNKEIGAKKGFNGQYTVECDKVDSLPDLTFTLTGHNFTIGAHDYVLEVQGSCISAFMGMDFPEPVGPLAILGDAFLRRWYSVYDLGNSAVGLAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ40</accession>
    <name>A0A9P4PJ40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2446019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ40"/>
    <dbReference type="OrthoDB" id="5371646at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="151" mass="16040" checksum="82BE326626D89323" modified="2023-09-13" version="1">MSDNEKNNGAGKAHSGWTDKERLVYMIGLLENTGTKLDFKNAPRPNGRSEIACERMVGRLKTAYKTELEALKAGQHFDGEATPKKRGAKAKGAGDGDGDGDGEGTPKTATPKRKGKAAAADEDDASPKKKGRKAAAVDVKAEVKDELQDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJM4</accession>
    <name>A0A9P4PJM4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJM4"/>
    <dbReference type="OrthoDB" id="5410873at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53370" checksum="AF08624DB899DC2D" modified="2023-09-13" version="1">MQRTQVSRLESLPSELFLSITEYAGFDGRLSLSAANSNCRSLLLQSIFRTLRVTSDEEEADEVLKLAKRIGGNVRAIAFHGTAGPNLSEEGKRDEVEDNTHPSPKTPRDSSIPEQVLPAPAAALLSGAHLPNASTLIVHFAFDFENNDLGDGIWDSRDDLSDGSSMYVFTVPETNQAMLAESEAEFPWRRLMSQTWGAASQNKNITSLVVGDLIPKAVTSWFDSQWARFLSQLSDADIQLWGGDNGAGWEVGTLDGYMYFVSQLDRYFLGAMTNVKKLRLSCYEHGPLGSRWTDVEDTMALRVRSGCLPRLEELRLEYAAICPELGEFLVARGETLRKVALHECFASREYRVDEEDVRMTWAELFSALRAARPTYDSFTVTNDAPPPLTFKEWQRSKDGGGGGEGKDADDEEESEGVKSVRAEMARHPEKMLFMYATLTDKYGDRWPELDVIRTHFQAGKDMEEFGKLMRLVGKSGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJT8</accession>
    <name>A0A9P4PJT8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_266219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJT8"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006058">
        <property type="entry name" value="PRK08206.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="1">
        <location>
            <begin position="31"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="363" mass="38636" checksum="805D4DED9F341AF1" modified="2023-09-13" version="1">MFLNPSATSWTYTGPPPSLSVLPFHRRLPDYNTTPLHPLPSLAQALGLAHVLVKDESNRFGLPAFKILGASWATFKAVAAKCDVPLDEGVGVEELGAAARKAGVRIVTCTAGNWGRAVARMGRYMQIVVTVFVPSAMDESTQEKIRSEGVKVEVVDGDYDATVLTARREAEGAGSILMMDTGWEGYEEIPQWVVEGYSTMLTETDEQLRDLGVGPVTHAIASVGVGSWAQAVAMHYKSTTPSAAVIAVEPGTAACLKTSLGAGKITPITTGKSIMNGMNCGTVSYTAWEVLRHGVDACVEVTDAEAHHDLQYLHSQGVKNGPCGAAPVSALRRLIEEKRLGLGRDSVVVLFSTEGAREYPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK01</accession>
    <name>A0A9P4PK01_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_260950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK01"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="75" mass="7813" checksum="05C894C7E9B102D5" modified="2023-09-13" version="1">MLVAMEVAGGVIDAGERPRLVLLAGRGEGKGRKDDFVRDGCAPSLRQKATLQLPVGVASLTLVGMPPSSRVQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKK9</accession>
    <name>A0A9P4PKK9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_431690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKK9"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="465" mass="51869" checksum="324569D2C9FF5522" modified="2023-09-13" version="1">MGYGGFLTLLNGSPKDWVVSGQHSYQMDKWEWPTVKAGTAAQVYVEWGQKGRQKDDAGEAYYTIDGTSDTFQVIGKKPDDFHITINLDNIATKQSPKGSSIDLGFRHDHAVDFIVSTDELGDWWSNAGDLTDWMQQSLGTLGNRTLKQICMPGSHDAGMSSFDAGTIGAHWTNSQTQVLNFYDQLVAGSRYFDLRPVLSGGEFKAGHYSEIEDIWLGGNGEKLSDIINQVNDFTAKYKELVIINLSHTLDTDNDYKDLSQDQWNQLFDKLTAVNNRFTADNPGSHDFSGDTLGSFITDRASVFIFAQLPSGISLGDYANQGFFNQDNFPIYDSYANSNDAEQMKKDQLDKLKAERNLVADDAQRKDKFHIFSWTLTQQAEDVLNFDKAILNLAVSVYDPLFVDAFNAFTPESFPNVLYIDAVGVRDKPAVFPYDKPENVGRNYDIISLAIAINNARAGKNVYITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLE9</accession>
    <name>A0A9P4PLE9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_253924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLE9"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="212" mass="23026" checksum="04D2B6BA0E7EB0AF" modified="2023-09-13" version="1">MGIIIKEASDADISRAAQGEADAYSVGGPSLLFPGPFAVPPVEARTNQIINLRKNDPTCQLLIAVDEETGDQMGFAKYHIYKTPEDVTSSAGRPVPSGPGVNEAACQAFFGGLVLRKKAIMGTKPHIYLHMLHTEPKYQRRGVASTLLKWGTERADQLGLPTYLESSHAGHILYGRHGFKDAETFECDMIPFGGDKTFTAPLMIREPLKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLF9</accession>
    <name>A0A9P4PLF9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLF9"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="375" mass="41247" checksum="B560F9934C5E5C24" modified="2023-09-13" version="1">MTSEHDLTTEQGLSAYLTSHSISHVSVSILTGGTANYVYRVTFPDGSTAIYKHAAPYLHSNTAFAFDPRRMDYEDRILELLPSLLSSRLSESPVHAVAVHRYDKGNKLLRISDGGSRNLKDTYANPTLDIPSVGAALGRWLATLHTSTVATPLSLDPASQNIKDNNAVAVSIYRHSYNNLSSAFAAYSDGGGTVPGYADFIDLPNKDIEFAQQINDAYGSRLAHDNECICHGDFWPGNVLVRPAAEEGGKVNLTVVDWEMTRRGTSATDPAQFLAESFLLDRFCGDRGLAPAFLNAYLSARSSLPDKEWFRRLAIHFAVHVAFWPTRVVWTDRAGTQALVELGKGILRAASESNWDVLFGLPVFGAMEKRYRPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLP2</accession>
    <name>A0A9P4PLP2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_407518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLP2"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2447399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="574" mass="64388" checksum="E61F223D8B453A6D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLP8</accession>
    <name>A0A9P4PLP8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_257849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLP8"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="578" mass="63303" checksum="596A13E5B7ED904D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLS7</accession>
    <name>A0A9P4PLS7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pantothenate kinase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_359160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLS7"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000005">
        <property type="entry name" value="Probable pantothenate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2445244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="461" mass="50842" checksum="440669ED66407E6C" modified="2023-09-13" version="1">MSPPSSTHPDPTAGEPGRAASTPAAHSTSAAVPTRPRRTTAQSDIHETILHPGNVRINVQGAFIVSDEPTTPRSDDYEHDPRDIRLPNHTAVVSHVAVDARNPLTIGGSLAKLVYFSREPEESSLGGRLNFLKFETDRIDSCIEFMRKLQADYRRQNGSAPEELCVMATGGGAFKFYDKIREALGVEVIREDEMECLIIGLDFFITEIPDEVFTYREESPMDFIPYPPQPPSIYPYLLVNIGSGVSMVKVSGPRQYERIGGTSLGGGTLWGLLSLLTGARNFDDMLKLAEKGDNSTVDLLVGDIYGAGYNKIGLKSTHIASSFGKVYKMKCAAEREAEDGCNGDHYSEHDHVPGSSELPHPPAKFRSEDISRSLLYAVSNNIGQIAYLHAEKHNLEKIYFGGSFIGGHAQTMHTLSYAIRFWSKGSKQAYFLRHEGYLGAVGAFLKRQPRNWGRRGSFEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLY3</accession>
    <name>A0A9P4PLY3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLY3"/>
    <dbReference type="OrthoDB" id="3753493at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="462" mass="51321" checksum="4AD52CA206458EA1" modified="2023-09-13" version="1">MSFNSNHSNPKKRSAQAEDEAPRAKFPRSAFTSFEGASLPSSPPLLPLSSSLPEMHTHVEHPDAGLRLPFSLANLAPENSKKKRSKSFQDVRDIEITVKKPTNKPLGFSLTPSTSPRELDEAVVPVQTEFKGPINVLDARTGKTTTTRDPRGGFGYDPEANFTPESSFNSFSSVKTVVRHPISSTGLGPINLVDANTGKILTTRDPRGGFGYDPAVNFTPDNSFDFVQTVIPPSRFTLDSHNRPLYGISLFGPARPQEEDDDDDEKTVVGSPEDVANKDEFPSSSQSSFPVSNIIEPNSSFDDVLVCRQQGDFSFTSPSTKHCSAAANMNDIIEAEYYAEKLLRERPGSENICETMCSRLERMVNAKIAGAKREAKAKKQKVVIPKPVDAAVQLQKYLLDQKEMRLQMGEVKEIVELELRWTNWLVDVTKSGVMHLKVPGCACRPEMMVWDDEEARKKKDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMK3</accession>
    <name>A0A9P4PMK3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_429493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMK3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="52" mass="5835" checksum="B73DB3C421E59227" modified="2023-09-13" version="1">MAMWMYTVFAVLFGLSLLRGFAWGVVTDLLAVLYHSGNRHAETTKKEGMGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMS5</accession>
    <name>A0A9P4PMS5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_484343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMS5"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="437"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNG8</accession>
    <name>A0A9P4PNG8_9PLEO</name>
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        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">P171DRAFT_430151</name>
    </gene>
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        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="120" mass="12780" checksum="FBF3BEF124A78E40" modified="2023-09-13" version="1">MSADAESARRTAEARAAVAASLAAVGSSVDNEMRTRATDLHKNSEAIAKQEKDLAKATNALAKESAPWQKLADTSTKKLNEIGDIQNWAEMLERDLLVLEETLRLVDGQDAPDSASGTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="188" mass="21274" checksum="944544A36B6C605D" modified="2023-09-13" version="1">MQDTNATIVEDSVLRQHPIRAASNSEGESRLPGLPPEIINNIARELFNQNIASLHLVGKSLYLSRPAEECERPPIHLRTPPEIVNNIARELDDEDTVSLLRIDKELYDRTKYAFEQLFLKHVHVFLHPTSFDKLQHLVNDPFYACAEWVVGQMRLLGVVNGHEGHIHTSKGVFSLLIKATIVLASNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNY6</accession>
    <name>A0A9P4PNY6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_230369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNY6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040174438" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16805" checksum="D7033B0D1D6D9FED" modified="2023-09-13" version="1">MALSSMVVGVILQSLHLCRMLQARGMMDLHSWNESTAVRATARRRLVCILQLHVLCTQQWPFHMHAHVGVGDGFVARSGAASCFKLASIQPSPLSAWGSVHPTMRVSHTKKQTMLCPILGWHHADILAVRSVVDSRSSPALARRAPHTRTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP07</accession>
    <name>A0A9P4PP07_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C6 transcription factor RegA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_462652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP07"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2446291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="97978" checksum="8AB313CEE28CD3BA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPN1</accession>
    <name>A0A9P4PPN1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_510357</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPN1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF15">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="64"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="391" mass="41982" checksum="49421D8EF4237FE9" modified="2023-09-13" version="1">MYTTVGRPLDRTHRRPRGLDPTCPFNPDHIGAAPFDLRFPYTGSIDGLPGTGIGGIQVPAPGDTTHEFTPPGPNDIRGPCPDMNTAANHNFLSHDGVTNLAELVSAQQNLYNLAYDLAVFIAVRGVALDGDVATTKLSIGCDAASRTSIDPTGTLGREPGLNAHNKFEGDISLTRRDYFLNNGDMFADMYRVANETSNGLFGRDTIAAYRSQRYDESLAKNPTFYFGPKVLLPYGSASFIYDVFPVFGPEGDATIDVVSTFYGAVPNAAGTYDHVPERIPDNWFNRRTAYGIVEIAEEVIYQYAYAPKLIGGNVGAGNFVALNTTFGVIENGPIPGDATAADFACLLYQIATDNVPGTVGNEADLPLDVLAWVLAQLNPVFGNLGCPLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPX7</accession>
    <name>A0A9P4PPX7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_315762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPX7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="293" mass="34091" checksum="EE55AD77023C8F53" modified="2023-09-13" version="1" fragment="single">MRLLNTNTLVLHSFVQRIPPYVILSHTWGDGEVTFDDIHQDHAKNMQGYSKIIKCCEQAVRDRYKWTWIDTCCIDKRSSSELSEVINSMYKWYWDAEIYYAFLSDLTSNLDNFHVSDLRLVRWFTRGWCLQELLAPAVVEFYNADWVYMGTKSSAVTNISARTGIDKKYLSDRHSIEQASIATRFSWASCRETTRPEDIAYCLLGLVDVNMPLLYGEGDKAFYRLQLELVQKSNEHTIFAWNPQEFRASHDRLGMLAPHPLAFSNASRINVRNRDDIKTFEMTNSGLRITLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQM2</accession>
    <name>A0A9P4PQM2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_407672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQM2"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01709">
        <property type="entry name" value="RT_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="963" mass="110096" checksum="5AF266C62EAAA62E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR70</accession>
    <name>A0A9P4PR70_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_428705</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR70"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="8"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="231"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2448662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="326" mass="34373" checksum="B1AB53DDD244ED5B" modified="2023-09-13" version="1">MSPKSAVISVIGSLNVDLVTRTPRVPVAGETLTTESFNTGFGGKGANQAVACARLSRTQKQASSGEASDVDVRMVGAVGDDEFHKGFLKSLQADGLGTKGVKILKGKKTGVAVIIVETGTGENRIMFSPGANYDVQVEDLVDDDAAVVLFQLELPLQVVLHNMKVAREKGAETIINPAPAIPLPDEAYNGLDHLIVNETEAAILSGIENSTSWDEVASVFVRKGVKNVIITLGGEGVYYRTDKQHAQSQPGKIVPARKVQVVDTTAAGDTFVGAYSVAVARWKSSSESTEFDLDSAIRHANLAASLTVQKAGAQSSIPWVNDVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRH0</accession>
    <name>A0A9P4PRH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_428896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRH0"/>
    <dbReference type="OrthoDB" id="3799951at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="449" mass="51615" checksum="80B5BD3376A055D6" modified="2023-09-13" version="1">MAQDAHGGPCLATLSNELLLEIATHLERDYQYTSPQSTSLKNLSLVNHHFRWLLRPLLMRSIVLAKPPSLAGQTSLRWQPSVRVWNQMREGIHFFSVDANMHSQIKKMQLEIPVYIDEAEKFRNSKTPTPKDEIVKFLTKLTSLEHLHLQTPPECNSSALDYARKPKYLARRVSVADPACRYYLDSLPLYARIMDDIIPPLCFANVTTLVVDQTMVFLLEHCPRVRHLGLFNSKDEYRSPFVGFGYYSKFAPHVTHVEARARWSSAEIPRLIRAWPNLQHLGVFPANDPEPLKLGTLLKDLARSSKRFKVLKLAGFCVDSFWASGPVRLSNLFLNTENVLAHWINLSEEIELPWETFSREHAGQKIMIDVMEMVFRSLGDLDECRIGDVAGARRVWDDHPSDYSGEFLRPHGDGHDGQPWTLRFNWLENAELRGPVKGKWDGDWLLRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRH6</accession>
    <name>A0A9P4PRH6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_518279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRH6"/>
    <dbReference type="OrthoDB" id="5386682at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="64"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="624" mass="69009" checksum="09616E6CB4C9998C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRL9</accession>
    <name>A0A9P4PRL9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_222305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRL9"/>
    <dbReference type="OrthoDB" id="3791583at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="81" mass="8900" checksum="8A9843EF16438037" modified="2023-09-13" version="1">MTSYAPSTTTRSSIDTMKSDQPTSTVSIISTTSSTKSPSKTRQAWEFVKKHAKEHHESVNAAYMVYYGQGTLRPTGNGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS36</accession>
    <name>A0A9P4PS36_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_439751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS36"/>
    <dbReference type="OrthoDB" id="2013942at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040376555" evidence="1">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="224" mass="22832" checksum="ECE0FF1EDFBC4A11" modified="2023-09-13" version="1">MIFLKTLFLASIVAAVPAQFDDRAVPAQLDERTVKVDCKAVDLVVKALKIAPGASKYCSSVLKIPTVTTTSTASVTNTATATTTTTALDFITSTGDQGGTSTITAPPVTQVKITTRVVTVTLVLDKKRDLGGRAVAAATPANKCDGSPLAGFACGLVSSACNCLNLATPTSTVKTTKSTTTTATITATVTSTGTQFVPVITTTTPTLIATSTSVKVVTVTLVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSM6</accession>
    <name>A0A9P4PSM6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_427719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSM6"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2449520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="571" mass="63341" checksum="DCD8B996828FCCD5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PST5</accession>
    <name>A0A9P4PST5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_377936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PST5"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="84"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="369" mass="41996" checksum="7CC34A9F0CBED3F1" modified="2023-09-13" version="1">MARTANFSLDTVGPFIVWQFIIPYAATWVQSIFYSIFIRAGEPKPMPGSPRFMKHRRQILIVTYLAYFFFTIYESDYNIQKSSNAYNDLGVPIDVTENALNSRFRRLTLKYHPDKFALKDQARATEFYNHLKSAREIILDPAKRWAYDRFGPGIFYSCAKCVTIKEYTDSALFVAMGTYGALFLFLIGTNALGFLKDGAYWRYLAILAVAAYDVRTAMRPDHPPFIAQWLNPLVTGLKLRPAYLPFQVTSIVKKASISAAQFLGLLIPLYRDDPQKPAKVTDDTDESRHKQLDRLEAVVQAGNQDVTRILELESTIFKENERAKGELKGAMTTYMVQNVIHQEPEVRNLIGQRIGRRRAGAPHGAQGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTE3</accession>
    <name>A0A9P4PTE3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_352736</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTE3"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF31">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="276" mass="30388" checksum="543346C8EE75383C" modified="2023-09-13" version="1">MWCLAAIPVKWSICFTLLRIANKQLLYIIPIYCCMGAVFLVMTSTTIYEFFHCDPVAMNWKPTKIPNGHCNAQSNITGFSYALSAVSIFTDWFCALVPIPLLWKVQMDLRIKLSVIALLSIGIFASIAPLVRLSITVNLSATEDFLYNAMDVAAWAQAELGIGIIVANLPAVRPLLEKIFSMRSTIRSDKRSKQQKSTERYLELEEGLSSQKHHSKSASPKGTETRIYGGTTVAGDSNSTLGDDHSQKNIVTSSVQNDAGNGIMVGREVHVRVSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTK3</accession>
    <name>A0A9P4PTK3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_461366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTK3"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="255" mass="28664" checksum="3B773F3A6BCEF136" modified="2023-09-13" version="1">MRLLCLPGAYGSIEKFKVQLAPLVKELQDDKTAEFHFVQGPYEVAPPEGYEEFFGGPPYFRFIVPEGEEAEKVDVIERIRDFPQLETPEMTMRELMTYGVARTDKSAADTLQYLYDLMENEGPFDGIVGYSEGATIAGTLLLHEQLMQENHGRMPMFKFALFFGGWPPMKPTLDGIVLADESELTIDIPTCHIIGSLDPYLHGNMALYNVCDPDSAYIFDHAKGHTLPRDKHMVKELGDIVRRMIVEVNGGVSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTL6</accession>
    <name>A0A9P4PTL6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_405722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTL6"/>
    <dbReference type="OrthoDB" id="160054at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35396">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35396:SF1">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040108167" description="Small secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="14749" checksum="67AA1F116CE4179C" modified="2023-09-13" version="1">MRSFALVSVLALAAGVTATLDPADTNTKGKYPSKPSCSPVKTSNAIQAAECSHNTRTSKQTFAVFTIDHKYDKVNGAPYGTCKAYNCAPGTAMTTSADAWTFFWSNAGESKGDGAGCIKSPDDGVCGCENSDGTFVPGGSNCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTX5</accession>
    <name>A0A9P4PTX5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_3212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTX5"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF4">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040543507" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="419"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2451284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="479" mass="51377" checksum="08F8792C06218983" modified="2023-09-13" version="1">MRSLFNSLAVLTGLLTSVAVAVHPVEVKGQDLIDTVTKKRFMIVGVDYQPGGQAGYKPQEGSDPLTNKSVCLRDAIMLQKLGANTIRVYNVDPTLNHDDCASIFNSAGIYMIVDVNGPQSGESINRAEPWTSYHKDYLKRIFGVVENFKNYPNTLAFFSANEVMNDLKTGKVNPQYIRAVQRDLKAYIKTHADRPIPVGYSAADVREILEDTWAYMQCDNNGDGSESDIFGLNSYSWCGGDATFASAGYNTLVDMFKGSSVPVFFSEYGCNEVMPRVFDEVASLYSDKMAALSGGLVYEYSQEESNYGIAVINDNGTVTLRSDYDALQKQFNKLDASKFTATGSSITAPKCDKKLITNDAFDTNFTLPAVCPGCQTLIKNGIDKPTNGKLVKVLDTKSPNKVYGSSGGEVPGLTLKLLSNDGVNTPSGETSSPKSVASTSTSTSTEGSKGSEDATGAASKLAGGWTLLAAGVVAALTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTZ5</accession>
    <name>A0A9P4PTZ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_426672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTZ5"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="81" mass="8851" checksum="BB4D2FE8B064A209" modified="2023-09-13" version="1">MTQNIGACQGECACSTCHVIASSKEHYLSLDSPTEKENDMLDLAHGLTETSRLACQLRMKRDLSGVEITLPGITQDVQKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUU0</accession>
    <name>A0A9P4PUU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_348096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUU0"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="690"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1114"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1123"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="7">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1133" mass="125698" checksum="34D9CD5E3CB3A1E4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV17</accession>
    <name>A0A9P4PV17_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_14713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV17"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF236">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2451899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="436" mass="48221" checksum="BCD309D3FEB5D686" modified="2023-09-13" version="1">MGSMVYQRLPTPHNPPLTAIVIGAGLGGCAAALALHHHGHRVLCVLDKVRSFGRLGDSLGLGQNAFDLLAKWGCDVDQIKRIGNQAPDMTIRAWGDGRELARQPLMDMAGYIGHRGDYHDVFLGWVRERKMEIRMGSEVVSFDDGPAQAGVTLRSGEVLKADIVVAADGIKSLARPLVLGCLDAPVSSGYACFRAFFRPTVEQRRDGTINRYLRGGDCVNFWIGPDLHLVQNTLRGGEEFNWILTHKDEGDVPESWFQEGDMGEVRRLVRTLDPEIRGIVEATERCLDWKICYREPLGSWVSAGGHRIALLGDSCHAHLPTSAQGASQAVESAGCLAVCLNKIRAKDEVRIATRAYEKLRFPRTRASQTNGEDLRDRWHGALKGVEEGGVIDPESVKIRNRWLYAFDAEEDAGERWDEVRRTVEDEFASGGIKPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV92</accession>
    <name>A0A9P4PV92_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_427137</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV92"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2450852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="538" mass="59703" checksum="E52C3AD1F8DA1F05" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVM3</accession>
    <name>A0A9P4PVM3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_196402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVM3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="210" mass="23203" checksum="DA095748A56DD5D7" modified="2023-09-13" version="1">MLLWILPSCAQHVKVVPGLAVLNHGAQERYVCKLVIRYLPDAHMAQAVIFEAELDPGLLSKGAPALRSTGSHDPGRACAAVARCSSILQVLMSRVSSVFCCCRSRLERRPGAETSTRRRSVGVEKVMLAWGARGSFAVSSPALRVTKGLVWLWLSIVAFGQRAIGEDRRGRRCSTRRCGCRCIRSRNHRRRSEQSAKWQEVVLPVGRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVQ8</accession>
    <name>A0A9P4PVQ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_346610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVQ8"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="254"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="318"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2451170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="517" mass="58813" checksum="22E32F5F3FE6A164" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVX0</accession>
    <name>A0A9P4PVX0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_351404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVX0"/>
    <dbReference type="OrthoDB" id="5342093at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="76"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="398" mass="44130" checksum="F3A22A79B85B7A65" modified="2023-09-13" version="1">MDSRPPAPARTSSISATATAVNTPDKALFPQNAARPDNDSLGSSLSSISSDSDSEESDDDTPTAEGKLPEDAVEGWPQLAQLMADQPDFAAFPRFRDLNVKSLLYYQVELNSLRKKLHKLEHADKAHSRNKTYSLYADTLVNEANASEQLQTMRNIRMTLKEYNEALLQYSKVCALPDPEPFNMRTLRRWLRHEECGNFNIRDLDDGGPVNTWGLLADNPDDKEKSLWSQFGSLLWSLVWMRRPEKSMYEPDLALTAPQIQVDGLTHWYASEWIPFRRALNSRKQRKGKNGSTDVEKTANRDTTQGSTVQAAPWAKKAQKEKTLVSWSQNSALRLTSGVSTVVACLLPVIAISVLSQLQGLKALLVCLAGFSLVFAIGLIALTQGTSKRTEIFGATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW57</accession>
    <name>A0A9P4PW57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_468703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW57"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040479549" evidence="1">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="151" mass="16317" checksum="05442516151677E5" modified="2023-09-13" version="1">MRVFTLLALVLSPLLFATASSVANEPVTSPTDTDANTAEINGGLYACEGYNFTGNCFWNPPERMRSCVLLLIGKPSNGFGYKPRSLGPDRGGHCDVFKGLICNEQTLVKRIDWPGVKNAAELSPASWDSIRCYATAARAPVHDEIAVKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWG1</accession>
    <name>A0A9P4PWG1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-xylanase</fullName>
            <ecNumber evidence="7">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_503176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWG1"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040216883" description="Beta-xylanase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="11">
        <location>
            <begin position="142"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2450598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="422" mass="43732" checksum="25F03763E7D9A9A5" modified="2023-09-13" version="1">MHSLYFTVLTLSSTSAVLAAVPAYGQCGGSSYTGDTVCAGGSECKEYNPWYSQCVPGSGGNSGAAPSSAPAAPAPASSSAAPASSSKASLPAGTSAAAAPTTLLTRASNPATSGAAGSGANGASCSINEAFKAKGKKYFGVAADQGTLSNALNAQVVKDNFGQVTPENSMKWDATEATQGKFTFTGSDALVKFAADNSKLVRGHTTVWHSQLPTWVSSITDKTTLEKVMNTHIQTLIGQYKGKVYAWDVVNEIFNEDGSFRSSVFYNVLGEGFVATAFKTARAADSAAKLYINDYNLDSASYAKTKAMVSNVAKWIAAGVPIDGIGSQSHLAGNWPISDYPAALKSLCAVASECAITEMDIKGAAVSDYKTAATACLDLDNCVGITVWGVSDKDSWRKESNPLLFDANFQAKDAYNGICSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWN3</accession>
    <name>A0A9P4PWN3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_402426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWN3"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="201"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="638"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="638"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2450176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="819" mass="91829" checksum="8BA3C89588A53CFB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXA0</accession>
    <name>A0A9P4PXA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_479182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXA0"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="77"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="509" mass="58218" checksum="6EA41C41316E30AD" modified="2023-09-13" version="1">MSPESIDLKHTTASDRSLTQAQAWVEACVSKHVNCERGYSNPRYLPIRLIHIGTDGDIWRLCEYPQLVGDTLPPPRYVTLSYMWGQHQQLLLLKSNIAQFRRGLPISTTLPNTFRDFVCVARRLSVEYLWIDALCIIQDSPQDWTTESMRMRSVYANAYCTIAASWGTDPTKGIFSERKVDDIRCSIIQIAWQDRQSTDLSSCRLVEKDGWAHILEGSPLDHRGWALQERFVSPRILYFTKEQILFECDTHVQCEAFEDDLPQDYADAMERRHRIFTWLDQAKEGTVQSEVRANHNVSPKFFKGWIVIVEQYSRCNLTKRSDRLIAVRGLVELFEHLSGDEYLCGLWRSCIWSSLLWYVDGPSSDTNYDIAPSFSWAAIDGYISLAPRELNLNIFTPFALIDATPQFLILCDFAPLYDPYNAIPLDELLEDTNCNHSMYTDLEGGDGIIVRPTSGLEGEHCLQCLRVGYSSYEYGALSDRSLAAFGLYADQDGNIKEQDGLKKVDFVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYU0</accession>
    <name>A0A9P4PYU0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_4945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYU0"/>
    <dbReference type="OrthoDB" id="3788956at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="466" mass="51071" checksum="F991DA36F5E1BBB7" modified="2023-09-13" version="1">MRSTKVESSLFPMMSHAADFHGDQLRLSAFLRVMGKVPERPKRLQQNRQAPSSLTNQHDSTSGTHLSLARHASVEEPAQDDSMGLPDDSMPGLESSGRTPEESSSKRVNAIFRSVSASSATEPLEIYAQTGSDFEQLNADPAKASSTVNRKTKVVYTAKKQLKQPMGILNAREKHRLPENGLVFVRASTEDGLPLPGDVDIVSVGLMGGIDPIQDSQLGRLPGELNNVRVGAHVKPSDISKPSALIPTAKGDPQQAKRSRPLASRILTFPGTHAPSRHHRCLRLPDPAPKVNRRMRQSERPVGITKAEAKVDEWRGRLQLASGFLPVSCPIQPTTPKPSNIQLNEHNSQLELVHPSAETDFQHLRQDSPPPRPTVEIIIRSQLAGITAPLREEDESDPSSLGEESNADLSRWGLEDLPKSTESDEPDLPSPGFDPGVEDMNYFGEAMYGLNDRDDGDFWSQYPGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5U0</accession>
    <name>A0A9P4U5U0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_369712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5U0"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38220" checksum="854D84C4457B30C0" modified="2023-09-13" version="1">MNASATIRSAYVRASVVHMRPPGMPGSTPERRPVNPEKLHEFKKVDHIRHREECEKERATTTTEDCELKPTTVANDTQSYMDFDDGETARSRIRKMFTKFPYRDPIYLVSVVFAFGSLDLVINASFDLLPRVAPESKFETEETVAVPTTVLIGSILFFAAGIFDVFGALNADRGTLETSKEDLGAVTYKPALLGSPEFKWLPSKMKFIELFTTSLAFQAGLIVLFGGVIFMFAGIVDFPGLISEESPLFSSIVFGPQVIHGFLFLVANAMLAISEQDKWYLPKIKDPDWLGAFLNATGGFWFMMAGFFFFQKDELAAATAAMVGSWAFLIGSLVRWNVVMEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6L0</accession>
    <name>A0A9P4U6L0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_458857</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6L0"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000012">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="16">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="573"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="124"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="320"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2438248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="854" mass="92752" checksum="4B0E4CB2BBF30944" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6P6</accession>
    <name>A0A9P4U6P6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_170363</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6P6"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Vps27_GAT-like"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="468"/>
            <end position="732"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
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            <begin position="503"/>
            <end position="512"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
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            <begin position="520"/>
            <end position="540"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="634"/>
            <end position="643"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2438232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="732" mass="80498" checksum="D7E0AB81EEB1EEB1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7H2</accession>
    <name>A0A9P4U7H2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_92027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="171" mass="19320" checksum="ABCA205422909852" modified="2023-09-13" version="1">MMLLEGGAGKKYPEGYHTSPRPSRSDAPACSGRGLHCGPLTQPSGETHTYRTQSCEASIGELIWTFSETNPTGLGREPYRFRRRNGPRAALSEQIPKSKFPYDPNCCAHVFALSSRSKFAEPVVILLEHEDPVRRPNRPYLYRTASLLCPRKDTGGLFEIFVFWHPTEFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7W2</accession>
    <name>A0A9P4U7W2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_501535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3790435at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="309" mass="34565" checksum="C4DA585A8241BF6A" modified="2023-09-13" version="1" fragment="single">SSYSSQSQPIYHNRHTQDTQIHLSKHQYINPYFPAMPHKSQRRTPRPPKPAPRRIAPRPTGVPHAPPTAPTALPTPEGPTKPYHPLPPALAQQMKTLIALSRRLESILHGLSYGLFTTPAEHRDAQTRLKHLRTVYHSLHPHVDRELASLGYLPAPCSSNIPHAPAPRKTPPPMLNTMAYAHASPKQKYGPTSPQYTVDKALKRKADSRDRAAALPPAKKKQRVDVDGAESDFVETDCESVDEGGREVEAEWPPAPLTNLAKEVPLEEAEWERIMGWSWGWAVRRGRDAVVGEEEEEWMSSPLGTVVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U814</accession>
    <name>A0A9P4U814_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_500348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U814"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="175" mass="19681" checksum="282B9B5066A1540C" modified="2023-09-13" version="1">MTICLQIWPEASGAKMVRPRLAVEAPAKIFTCLDAEARGALIRLESPPTAAESASNPTEPGHYQQRFPRMHAFRTQVDTPAAQAASSLRSARSLIFEIWLARVRRRQLGSGWPPRVALRTLVCCATLLDASWHTGDKFIISFDKTNEKNELIYACLRYPIKKAVTNPQKIHNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8M2</accession>
    <name>A0A9P4U8M2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_448116</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8M2"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2440197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="206" mass="24080" checksum="A524848A78CED033" modified="2023-09-13" version="1">MANYLASIFGTEQDKVNCSFYYKIGACRHGDRCSRKHVKPSYSQTILLPNLYQNPQYDPKNKMNPQQMQMHFDAFYEDIWCELCQYGLVEEVVVCDNNNDHLIGNVYVRFKYEEDAQKACDALNSRWYAGRPIYCELSPVTDFREACCRLNSGEGCVRGGFCNFIHQKQPSPELDRDLDMSTRKWLKERGRDERSMSRSPTPPIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8N4</accession>
    <name>A0A9P4U8N4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_433977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8N4"/>
    <dbReference type="OrthoDB" id="3511049at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="3">
        <location>
            <begin position="286"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2442489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="499" mass="56541" checksum="C69D283E6BDFEF62" modified="2023-09-13" version="1">MSSRLSPPVPHNPSRRFQHDLAPPPKFNLYDKQRDATSSANEFTVLTHQESRNSRSQSTPNPVQQNLEKTLRSELSIKHDKRRPSLTKKPRSAPGGTANVGASISNDDSIDDSIQTPHLQNNRVPSLCGKQSYSSPGWRKKHEASCAVCRNINLKETSQVQVCDTTLDSKRQATPESEETRAPKAIDEQLGGTGGTLLSVNREALEDLESGRDRVPSLRDDGNDPDVVHVMTLGLEDEANPDGSLVANSSNIEINATELHNKVRAVLEKGLTPNDSEGYIYILSDPKRPDLHKIGRSKETIRRKRQLKYQCGLTLRLVKNVQVDSYCRAERLIQTYLLDLCRPYRCEVCGASHGEWFEIAAEPASAAVSRWASYMTQENPYDPETRQLRPFTKDLVKRRDHFLADANSKIETTREHWNRILSPTSLDRFRFKFTVVWDFLWKFYWPVNTIFAWTVAFVVSRHPVTFLFMAASVVGTFISMSDEHHLLRNDSKSSKKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA80</accession>
    <name>A0A9P4UA80_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_485689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA80"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040419271" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="49" mass="4924" checksum="E4BA0DA096E36DEF" modified="2023-09-13" version="1">MKFTAVIAAVLSMAVVTIAAPVAVAEAEAQNHGMCVSSDGTTVTQITNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAB7</accession>
    <name>A0A9P4UAB7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor rse1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_522568</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAB7"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="8">
        <location>
            <begin position="21"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="9">
        <location>
            <begin position="463"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="7">
        <location>
            <begin position="882"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2442881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1243" mass="138183" checksum="70E4A555DAD08BC3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAH2</accession>
    <name>A0A9P4UAH2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_455269</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAH2"/>
    <dbReference type="OrthoDB" id="5271017at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040238149" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="18"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2444514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="233" mass="24646" checksum="FF38991037BF4CD4" modified="2023-09-13" version="1">MLFLAALILVAEIAVQAHYTFPRLVINNQPSPSDWLTTRRTKNADSKTGIENPTSPDIRCYQAATAASVATIPAGATLHYLSTQQVNHPGPTQYYLARVPVGGSVKTWDGSGAVWFKIGTTMPSVDGQGQMSWPAQNSYQTANTTIPVSTPSGDYLLRVEHIALHMAMRAGGAQFYLACSQVTITGGGDGSPGPMVAFPGAYGRSDPGILVDLAKIVKAPDTYQPPGPAVWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAI9</accession>
    <name>A0A9P4UAI9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_432584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAI9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="95" mass="10611" checksum="2CB27AAD2578B389" modified="2023-09-13" version="1">MWLRIQMIIELFNRVQGSKGKRLVANAAVALSLCFVSADYVLEMNSELPMRFPVWWSLGALRHSAALTKLQTTDFAIGRLFLAPNEQPTGKSLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB87</accession>
    <name>A0A9P4UB87_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_521318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB87"/>
    <dbReference type="OrthoDB" id="3796197at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040327883" evidence="1">
        <location>
            <begin position="21"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="324" mass="36144" checksum="723D0A5C1BCC97E8" modified="2023-09-13" version="1">MRFDFAKLAILALFLATGRAEDSCDNEWEATDEISVHIWNNQPKGYPMDAPAMIQIHRGDENIFQVGAASQRTTFPEISGIDQGAGIILGVKARSTDWVNSIEFKMLKPNMISSELIDMVMKEDMEAWNKQQRGIETVNLDSMFIMNPYPTGGKDQTYEFGGTIRKENTQKLIDGTTNLWGSSISTTVGLSVVVPQLGDISNEITTSAEYQQTRLKQTEEERKEGKDITWKVGTAEGNLLKPQEAVKCSAWTLSGTFASPYTGTIREKWEDGSTFEYLTQGDFESIGWTKTFAHCEPWEISKIPSGARLGEAKDVSKRAVEFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB98</accession>
    <name>A0A9P4UB98_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_363507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB98"/>
    <dbReference type="OrthoDB" id="4194555at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="942" mass="104773" checksum="192393E7B721AB61" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBS4</accession>
    <name>A0A9P4UBS4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_521784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBS4"/>
    <dbReference type="OrthoDB" id="3792077at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="161" mass="16804" checksum="4504F1B7FAB1E2A6" modified="2023-09-13" version="1">MSSLPPPITPNTSTSTLSLAAHLSIATQPTMSTTTPSPTLFTHLKSQITSIALALYGAPSPSAFDIVTYTTPLPPSTYILLDGRPRDTPLPRLLSGVALVTYTSPGACTKWICLARCEGVGEREAMEGLLGDLRAGMGGMIGALDGEGEVVHRRVPDVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCM5</accession>
    <name>A0A9P4UCM5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_432381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCM5"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2444322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="374" mass="40107" checksum="A2B144D7A0E14193" modified="2023-09-13" version="1">MAVELVILSAVFVSITVVSIAIRLFTRTVILKNIGVDDYLICVGAIFAIVSSVTPIAALQFGLGRPTAEQRPEQVAPYQKLLLTSSVTYSVSALFIKLSLLSFFLRLSNGPAFSATVYAVIVIVISFGIGSVAAVLLQCLPLSALWDTEAAKGAKCIKLVEFYYANAAISLAADLVILLLPIKILWGLHMPLRQRIGLCALFGLGGLATVAGIIRLSSLKTLLSSTNPTVNIVTPLNWSFIELNVAIFIAGAPALKAFLRQYLPTLLGSSYSPTGATKYGSTNKTGTKSRPTKHNSIPLGSMHDKNDSKWVKNTAVISGGAAETGNRDRDSDNDSQENILQNYHGILQEVTVSVRSERKSEEEGRSVSSAKVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCQ8</accession>
    <name>A0A9P4UCQ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L37ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_242900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCQ8"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="92" mass="10243" checksum="DF62224421BFD00D" modified="2023-09-13" version="1">MTKRTKKVGITGKYGTRYGASLRKQVKKMEITQHARYTCQFCGKNAVKREAVGIWKCRSCRKTTAGGAYTVSTPAAAATRSTIRRLREIAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDD8</accession>
    <name>A0A9P4UDD8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_511977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDD8"/>
    <dbReference type="OrthoDB" id="5392263at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="161" mass="17987" checksum="2369CF85DCF24DC3" modified="2023-09-13" version="1">MRRPNFTECGDRYRSTNTLIEQYHYSGPVRLISPSPRTQITYHGCLALCGAGNEYYSWSIISATLTTWILPILGTLLQAPFESNAFWWTVKAINRWVDSPMSSMASILYHVEVSGKCALFSISRPATSRMRRLIPAVDMATNRLSRTSRANSVASATLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEQ1</accession>
    <name>A0A9P4UEQ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_453569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEQ1"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="141"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2447350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="425" mass="48522" checksum="A1EF5AC57BEE009B" modified="2023-09-13" version="1">MQSLVTPFGASYYFSSKSVTVDVYQGLVDRGWRRSGTVFYKPDVLRHCCPHYTIRLPVASFAPTRDHRQVINRWNRFVLGDEYSKEAAKLYPKSKADKAKQRNGFDLPGAVHESEYANTKRPPEPAHRFEVTLEEGKFTKEKYELFHNYQQHVHHEKPSEISQSGFKRFLCESPLQRRTAQVNGKTQQLGSYHQCYRLDGRLIAMGVLDLLPHCVSGVYFLYHSDFEKWSFGKLSALREAMLALEGGYQYYYMGYYIHSCAKMRYKGEYRPQYVLDPESLTWDPLEGELRALLDKKRYVSLSRERRLKEAAQGTGGHAVESTQHDAEPDSYSDFPYPTAKEASDAVSNGVSLFDVRVPGVMTEEEIKQHPLGEQRISGRNQVFVAEDLMAWEGGDIRDGSFKGITAEFVAFLGPDVAKQVVIGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF70</accession>
    <name>A0A9P4UF70_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_379826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF70"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2449689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20545" checksum="02CD4DFF5AB9ED7A" modified="2023-09-13" version="1">MTAQNFSKYYPAEDEAQMKKARKTAHPTKYRGSLQPGTVLILLAGRFRGKRVVLLRQLSQGVLLITGPFKSNGVPLRRVNHRYVIATSTTVDITGTDDEVLDRVSKDEYWAREKKEGKGEEEFFQDGEAPAKKETDPQRIEDQKKVDKAIMSNIRKVPDLDSYLAATFSLRGDEKPHEMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFP3</accession>
    <name>A0A9P4UFP3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mago nashi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_382296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFP3"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2447457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="158" mass="18382" checksum="DCE814789C07072C" modified="2023-09-13" version="1">MASENKVNTEPFYLRYYSGHQGRFGHEFLEFDFRVLGDGRSASTRYANNSNYRNDSLIRKEMCVSHAVVNEIRQIVKDSEIMKEDDTKWPQKNKDGRQELEIRLGNEHISFETAKIGSLQDVSDSSDPEGLRVFYYLVQDLKALVFSLINLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFQ5</accession>
    <name>A0A9P4UFQ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_468660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFQ5"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2450289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="652" mass="72759" checksum="76074172DC27FFA0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFU1</accession>
    <name>A0A9P4UFU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_452574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFU1"/>
    <dbReference type="OrthoDB" id="5356836at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF5">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="331" mass="38003" checksum="4B78205A4CCD49BA" modified="2023-09-13" version="1">MQRTVVTINSNGRQSASFIRVASALGWQVRAQMKELNGLVAEEIAQLPNVTVYVGRLQDRRFLDDLFRSAQYAFINTTHWGDEVAIGRALADAAKKAGIQHYIYSSMPDHSVFGNNWRALPLWAPKFTIEQYIRQIGLPATFVYCGIYHNNFTGLDFPLFRMEHQNDGSFVWRAPFHPDQKLPWLDSEHDIGPAIYQLFKEGPRKWYGKRIPLAFEVLTPKEVCRAFSRGLRRPVHYKRGPIVIHCPTPVGYREHLSALEWTLAESEAPYFGPDIEKDCPGVALELWEGNRGMEEYAQEVFPVEEAANGLTWMEEVETPRREVDLDFQVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG21</accession>
    <name>A0A9P4UG21_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG21"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="237" mass="27814" checksum="F1CE4D1CD690C781" modified="2023-09-13" version="1">MSTFPQFPLLPSELRLRIWELTVEPRTVDVSVSSYHYSKPLPVISTPVPAALQACQEARHELQKHYERAFTEIDNPPHVFEPRQYVWVNFDLDIIDIGPGWHFELYAKDAPKIQRLRFETADREDDLFQRSGIRRLRLYTNVREVFVVCKDGLDSWWRALDDYEWPCGVENVWFVDPDDGKMMRGTALDEMCEKDFRRRTIEQGWDPDTGLLLGCIASDEECRKCGDVHGYPIVYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGN1</accession>
    <name>A0A9P4UGN1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_218338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGN1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="150" mass="16790" checksum="8A0E3E22794D6929" modified="2023-09-13" version="1">MSSLDTWCSWRSSRLACWQRDKCFLKATTLRLYSFPQVHCQCFECVEAPLSVRAFRSCLSCPSILPEQNEPVAYGSTSLGYRVAVAVGGVVSSLLAHFVPRSRDYTRGFVVVPVAADEDKVLHKVRLPINIEVREPWVIENTAPTSELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGR4</accession>
    <name>A0A9P4UGR4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_427988</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGR4"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057213">
        <property type="entry name" value="DUF7891"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25421">
        <property type="entry name" value="DUF7891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="898"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="69"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="250"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="436"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2449856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1164" mass="127324" checksum="2B4DDE6DBE7959B7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH40</accession>
    <name>A0A9P4UH40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hydroxyquinol 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_468242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH40"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="9">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="8">
        <location>
            <begin position="117"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="298" mass="33099" checksum="E16452F79156FE42" modified="2023-09-13" version="1">MSQTNGTDGATKPKPQYDPDFTSSVIKATGPKANPRVAQVVGSLIQHLHDFARDVDLTVDEWMMGVNMINRAGQMSNERRNEGQLLCDVIGLESLVDEITNKQLVGADYEATKTAILGPFFRHDTPPTKNDTSIIKTMPKDGEVTYMHGIVRDAATNEPLKGITIDIWQCSTNGLYEQQDPEQAEFNLRGKLTTDENGYYGLYCLRPVPYPVPDDGPGGELLQLLDRHPYRPAHIHIIAGSDKYTPLTTQIFDKTSKYLAEDSVFAVKDDLVVDFVPVQGKENASLELTYDIKLAKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHD1</accession>
    <name>A0A9P4UHD1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_204594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHD1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14391" checksum="C9C4DF4355A345A3" modified="2023-09-13" version="1">MPLPLFHYFYRSGLPKYLRQDANGESSWALVTGASDGIGWGLSRQLADRGFNVILHGRNTSKLTRCREELEASFPHRHFRTVTVDASSLAWSSKDKLWQSVHRPGSRGGVARSRRGPVVSSSALVFGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHK1</accession>
    <name>A0A9P4UHK1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_460049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHK1"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="112"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="253" mass="28845" checksum="8668B65AD95FDE4B" modified="2023-09-13" version="1">MSSYHYTSETPAEVKDAKGLHLITQNTPNGQPLQIFLEELKDAYGTEWTTSIIDISTNVQKSDWFLRLDPNGRIPVLVDNTQSPPFTVHESSAELFYLLKFADKEDKFGFANDLERNQALQWTFFWHGSGAPYQGQVNHFSRAAPEKIPYAITRYRNETLRVFGVLEIQLSGKYTGTPREYLAGNGAGNYSVACWTFNIADIKTWPWVKNWEKSGFSKDEVAAFPHLLKWIDRIAERPAVQRGIGEAYSKKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHK9</accession>
    <name>A0A9P4UHK9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_198011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHK9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="92" mass="10771" checksum="8C0F391BD46E8BB9" modified="2023-09-13" version="1">MHPVAPWFGNESLRCRVLIRCSLWMWSNCSYPDRKLVSRPSVEDGCEEEKEERREFRVVGNWRTLTGYTLDFHLSSRFLAAFESNGLNSIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIC5</accession>
    <name>A0A9P4UIC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_426077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIC5"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="360" mass="39511" checksum="AF1C078D4F883A79" modified="2023-09-13" version="1">MPSTTYAEFGHDTEALEVAKAFADGIRGKTIIVTGANSGGIGYTTLQAFASQSPAHLILASRTSSKTQETVEKLKTEYPGVDYRPLILNLSSQKSVRDAAAEVLSWKDVDAIDIIVNSAGLMGLPERQLTAEGIEMHFGTNHIGHFLFTSLLMPKLIAAAQRNPRGATRVVNVSSLSPLVAGIRWSDVNFDKLNKDLPEEERPNEQMLSRWGFSDVLERSYVPLEGYNQSKAANVLFSIALSDRLYQKHGIVSIAVHPGIIQTELVRDLGKEMEQALSEMKKQGMAKYKTQGAGSSTSLTAALDPKLGEAVNEEKDGRVYGAYMIDCKISEMANVRACSRKEAERLWELSEKLVGEKFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIC8</accession>
    <name>A0A9P4UIC8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_349603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIC8"/>
    <dbReference type="OrthoDB" id="3749155at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040392336" evidence="2">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="330" mass="37635" checksum="04A8A3C215E77A68" modified="2023-09-13" version="1">MRFEGLSSLALFGLATSHAIQVRAPAEAAVAATAGDDDKGKNWRPHTKEPHFFNLRINDRCDPFNGPTPETLKSQCPFDSYAIRLEKGVLVATPYNKWWDPKLPTFFVDDDTQLYTVSKDPLQLYVDSVTGAVKYTKVGWLPPSAISTGFYHTGNNPIQLVDPSPSYLTWPSTYGITRGGNFALCPLGSTGQYQVFVNNWNFDQQGVEKRRCKYYALAALNANPWKKEHSKLKARDDYPTSDDYTTWGDDSEDSWSDEDSSYRKSDKDDGYETEKSGYETEEPSYETEKTYETEDPSYETEDPSYETEEPSYETEEPSYDTEKTYETEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIQ9</accession>
    <name>A0A9P4UIQ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_427175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIQ9"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="141"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="229" mass="24379" checksum="A1736C20265D1D68" modified="2023-09-13" version="1">MDDLHAPTVASGPTTGGYSNGVSKDQLSLQELIAEKDRVEAELKALGQVLDSHGVHMNTTLTTFDGFPRADVDVAQIRTTRARIIRLKNDYKELMARIEKGLHEHHARLQEQAQNTTAASASSLSAGSAAPSALEAPFAKVNSVVASSPAETAGLQVGDSITKFGWVDWTNHDKLARLAQVVSQNEGIPITVKALRPGAAGPAETIEVRLTPRSNWGGRGMLGCNLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIT0</accession>
    <name>A0A9P4UIT0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_439239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIT0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="158" mass="16772" checksum="FB6AC36D080C1F48" modified="2023-09-13" version="1">MSIPPEQSALPPSIAGKNTSGNGGVMLTLKLKPARSAAVNLTEESLKQPPRASLLTNDKDASGNCHTGPQSAQYANRKEEKHKKRSVQAVSAPEVPEQKRTVLPNHPRLYLRLRTCPSCCPSSPCSPCAVEPASRHLPTALRTSAGVSAMDKLDIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ96</accession>
    <name>A0A9P4UJ96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1760-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_459785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ96"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040347">
        <property type="entry name" value="YBP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020:SF1">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="696" mass="76958" checksum="0129F82B70A61772" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5S9</accession>
    <name>A0A9P4P5S9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_490946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5S9"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="201" mass="22148" checksum="EBBD54F717C13212" modified="2023-09-13" version="1">MTAGWVLVYGERGAIKWHICPSPPNVLECDELNCFDFIRHGSSPCTIFRCRYNRRHLYPALKPAVFILDEVQMRRLSGGGLAALEGLEPDITTLRKWVGGGVAFGGRGEIMRIPRDGNALAPSGTFNNNNTLAMLAGYNGLSQIYTPSVAHAFNAIGDKLRSALPELRQINVTGRGTVMGIHFLEDGKKDVKSYKDRNDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P689</accession>
    <name>A0A9P4P689_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_341795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P689"/>
    <dbReference type="OrthoDB" id="3904217at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="114" mass="12778" checksum="4E35F9194EF3CAF9" modified="2023-09-13" version="1" fragment="single">MSAILTPTHPAYRPQNLHYGKFENTTDAEWAVLGKHNLAYAAPFTLSVLPEEEEDDGVVVHGPLLSNVPSYDGSYFTRNFTILGGEGDGEYGRWLRLVIRNETSGIRGVLTWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6M4</accession>
    <name>A0A9P4P6M4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_449578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6M4"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01393">
        <property type="entry name" value="RecA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="36"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2437818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="431" mass="45779" checksum="A45354809C05DD53" modified="2023-09-13" version="1">MASRDVGFLSSSAPQSSHRLPTVSASQALETLHARGSRTVCTGLSQLDKHLAPHGLPGRAVAGGYIRGKVTEIFGPPGVGKTAFGIQAAVSALREGQKVVWFDAACAPLVPQRFTDVLLADGDPVLQASTAPPKVVGTPRTSPDEMRSHFHHYAIPTLAHLLALFMYPPSSFPPPNTSLIVIDSISTLFDNAYPRNADDRAAKNRSDQARWAAGRKFAVMNELISTLTKLAAMHDIALLLTSQTITRIRAASRALLVPAISGAEWENGISTRLVLFRDWVPGQAKWTKADAARMQKTRFAGVLKANGVGLADDGGVGTVVPFAVEKTGLRNINVAAVDIAVPVLSSEARPPKRRFAEIDEGGEEPDSDELYDWMEDDEVAAEGLLIGEAPTIADGDPAISGATAPAVSSDDGPTIASLAEEHNRVTRRPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8F0</accession>
    <name>A0A9P4P8F0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_121375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8F0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="164" mass="17224" checksum="D18819F61C077B6B" modified="2023-09-13" version="1">MKPNAAAGLAPRSHGGAVVCLQYAESGPRYGKDTGTSRARDGIVLLTAGWCAAAVRLSEPWAVSVHVWRLASGSGAWRDETARQLTTTSQSLERVSPCAPGVLERMALGQVVNHVLRLPTPRRLRATSRAGAAVRMGSHAETVGKRWRAPGMGVGVGVGVSSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8Q7</accession>
    <name>A0A9P4P8Q7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme-dependent catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_371261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8Q7"/>
    <dbReference type="OrthoDB" id="2379805at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="1">
        <location>
            <begin position="92"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="251" mass="27534" checksum="27DD7456CCB3F776" modified="2023-09-13" version="1">MPCAAPKAVNVSKSFRPAHAKGHLLSGTFTPTPTPQASLLPLHRPALRPPLDLPHRPLLLLHKPALDPRHRAHGQPARPRHPLYPETVRFVHDAKPSPASFATERYFGVNAYVFSDAAGRETLVRYRIEPAAGVQTLAAAELARRDASYLFDELVPRLAGGPVVFRLTVQVAGADDATVLWPEDREVVELGLIGIEESKGEESLREQKEIVFDPVPRVTGVATSKDPLLDVRANVYLISGRQRREAEVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P916</accession>
    <name>A0A9P4P916_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_436635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P916"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="592"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1044" mass="112481" checksum="BAC3491F6B091074" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9F6</accession>
    <name>A0A9P4P9F6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_113933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9F6"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2439860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="246" mass="26919" checksum="6AF3CC9B731E0347" modified="2023-09-13" version="1">MERSFLTCTRSLSRSLRSSTSSKTAARSISTALRPALLPQASQTTARHRRCLHSTPSYNESRAPRSRRDPPSDDNTQADFASLDVLRNTAQPATSIDACTSEGFALNNNMRIAGCGVLLVGGEAYRWRPWLSPRGKQETVEEGAAGEDAMTGWLLNAKGQWEVPDEAWGLFDVVWPKPDLLIIGTGERITPLAPATRKYLNGLGIRLDVQDTRNASAQFNLLATERGVQQVAAALIPIGFREARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9H8</accession>
    <name>A0A9P4P9H8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_129611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9H8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="126" mass="14906" checksum="ED7D16AC1DA557B1" modified="2023-09-13" version="1">MHSAWRSAAFYTGWFGVFRSLAGPVSGFFPLCFGGRARHVMYIGGMGSIDSRARCAASWQPSCIWPRLRESVYIRDYIFMARSRRLFIFVYRFLFLFLDYERSGFWVWSVAIERRWHSERALFCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA83</accession>
    <name>A0A9P4PA83_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_436071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA83"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="81"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2439379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="403" mass="44257" checksum="968DE73FB5DF6710" modified="2023-09-13" version="1">MAAKSPSIRALSRYLLRPQAVPHATCRQQRTPKRHSSAVAGARLNGPIEYDTTPLLYHTSKAALTNPELPEDVRKGQTKRINLYQAVNEALRHALQSDERVLVFGEDVQFGGVFRATMNLASDFGTERVFNTPLSEQGLVGFAIGAASEGMKPVAEIQFADYVYPAFDQIVNEAAKYRYMAGATQVHCGGLVVRMPTGVVGHGGLYHSQSPEALFTHIPGLHVVIPRSPTQAKGLLLSAIRTNDPIIFMEPKILYRASIEQVPVDPFYLPLDKAEILKTGKDITIVSYGQPLYTCSAAITAAEKDFGCSVELIDLRTIYPWDRETVLDSVKKTGRAIVVHESMQNAGVGAEVAATIQEKAFLRLEAPVKRVTGWATFTGLMFEPLIVPDVTRVYDAIKKTLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAQ8</accession>
    <name>A0A9P4PAQ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_435257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAQ8"/>
    <dbReference type="OrthoDB" id="3936451at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2440462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="442" mass="49836" checksum="192C42A621525658" modified="2023-09-13" version="1">MASPIPNRGPELYAVNIAFLVAAVIAYGLRCYVRIRMIKSFGRDDYLMAAATVAFIAYCSASVLGIHYGTGRHRWHLTTENYAKGRHCWWFCYLFYCCSMITSKLSIGFFLLRIAVRKIHVWIIYFAMMISIVAGLAFFFVTLFQCYPISFFWNDYSQSGTCVNIEIIIALGYLYSCFSIISDFTFAILPAFLVMGLQLKRRTKLALIPLLAMGCIASAAVVARVPYMKQFRSKDFLWETTDIAIWSTVEQGLAITAGSLAAVRPLFQAVLTKLGLVSQRSTMPLTPRVGGSPRQQHRPRHQRRRKRTPEATKLVRNAVGEDQAKFQINAGDQSEQRQREREESTDERDHQQRARLLPSTNLLGRTVDADHGGKEFLCYGCREEKLRRPAGLQAMTLGARNPGITFITLYPPTLPVLGQPLALALAICQPRGWHGAKKHFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAW6</accession>
    <name>A0A9P4PAW6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_523597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAW6"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="452" mass="50859" checksum="9E474A3759B3E53E" modified="2023-09-13" version="1">MDIDMDIDFDASALPATETTEQNDDTTVNDAPLPAAYYENLDERPGRQVEQWPESLNLQGVDGFDPNDAIYYLVESGVPQKIKQQRWVHDSSLNLQFYNAEDAALALKQLTDPQAGGDPSTIPAEVSRKAKPYKDLNLTIRQANTGDQKVRGAATYSRYYEKNPDVRGGDRRGVRGREQEPRRRQPPRRDFLDYGEDEPAKNNRRSRSGDEQMRDGSDYENRRNRRNGNRVRDDGRLKAVDVDSYRPGSQGPRESRFGRLRGRSASPVSGGEGDGRYGFTETGTSTRRQYRSRSRSRDNRRRKEPSVERWTHDRANYDREQGPPARWTKDTSVPRYGDAFSSESKHRRSDAFDDSTIRGGGSLLSRMTKDGQPLAPQGRSLASRITRDSDDSSYGRLKDDDSAPSYVDFSEPAPRRGLASRMTRDDEELEGINIRGTASQGGFSIRGVAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB30</accession>
    <name>A0A9P4PB30_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_435528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB30"/>
    <dbReference type="OrthoDB" id="5412288at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019622">
        <property type="entry name" value="Rrn9_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10680">
        <property type="entry name" value="RRN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="716"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="755"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="597"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2440761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="788" mass="87556" checksum="FF41D90C67260C1E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB79</accession>
    <name>A0A9P4PB79_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_435752</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:12653"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB79"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000001">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000055">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="14">
        <location>
            <begin position="94"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="13">
        <location>
            <begin position="285"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2439919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="609" mass="67499" checksum="CC228C908DA235C3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB91</accession>
    <name>A0A9P4PB91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_368976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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        <source>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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    <name>A0A9P4PCU6_9PLEO</name>
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        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HCR1</name>
        <name evidence="7" type="ORF">P171DRAFT_434581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCU6"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="277" mass="30784" checksum="E349434BD5A09D09" modified="2023-09-13" version="1">MPPSKWDDEEEDTPPASPPATTALRRGKFDDEEDDDDVLESWDAAEDSEVEREKAKKTAEAKAKAEAEAKANHKSRAQRIKERQEENMRRRLAGEEESEDSDEDDATRRARLRKSEQDADLAHAEDLFGGAGLSVGTKPRTAGSKAVTLTDESDPNNVIDLTSLKLFNPQTKDQFTQLRETLTPLIGNNSKKAQYSLFLQEFTKQIAKDLPSEQIKKIASGLTTLGNEKMKEEKAAEKGGKKTKAAKTKVALNASRDVAFRADTNAYEDDFGDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD25</accession>
    <name>A0A9P4PD25_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_418563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD25"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="500"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2441780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="776" mass="85335" checksum="3AEE3D6D2475E2E0" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDH3</accession>
    <name>A0A9P4PDH3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_418673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDH3"/>
    <dbReference type="OrthoDB" id="3010248at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="516" mass="59021" checksum="44A1D707275E373F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE16</accession>
    <name>A0A9P4PE16_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_433710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="842"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="641"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1130"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1130"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1159"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1177"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1221"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2442152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1590" mass="177396" checksum="2E83F33C29B487A0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEL1</accession>
    <name>A0A9P4PEL1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 128 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_434006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEL1"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="7"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="225" mass="26129" checksum="8CDCD87548B0F3B0" modified="2023-09-13" version="1">MDTVNFDGPISSVFNWNAWIPPELKGRAPFRPMIHLERELSGNEWQWIQDSDEQIIHFFNEPERNGISPQKAADYWHNQVIPALRNDRRKQLVSPSCASDPAGQQWTADFMNLVQDARPDYLGLHWYGTEASECQQFISSMHDKFGLPVVVSEIASVDRNYDSVHAFTRDMCNWMDGVDWIFEYAFFGCMQHMPDDFVSPAARLMDVGGNFTDLMWKYMSDQPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEZ5</accession>
    <name>A0A9P4PEZ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_390487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEZ5"/>
    <dbReference type="OrthoDB" id="5420958at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="123" mass="14483" checksum="284233CC78F104E2" modified="2023-09-13" version="1" fragment="single">MDKASRALVEGVPPGVPFSFRALADHREQKAQDQQYLTPWEEEALVKFILQMSNFGYPIRIKFIPALAHRLTLQRPRSARPRKPPHLNWTRAFRKRHPILEARIVGALDWNRHEKNIYPKSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFY2</accession>
    <name>A0A9P4PFY2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFY2"/>
    <dbReference type="OrthoDB" id="3763153at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="292" mass="32214" checksum="ECCC51BFE2BB55DA" modified="2023-09-13" version="1">MSPPATQREEGRPVSCPETGAHPHIQGLKEHQKTTITMFTENGINPESIVKATRHGGVQNLLQEAERIVGVADAWQTLYGIDIKPLIQLYNKYGKNVVEVCLVELVHMSQQGLLQVKQDVGNEAMLAISPKDDDLELSHPTGKVLGHPPKPAGKRLKSSTVRTDPLLRPSVTENWPPFPSATASRSLSSSGFAGKRRIVGQVCAPRCPNYMKRQHFINHALLKHNNNLPSQTVWICCCDKSYTDDEAYLDHQWNQHSDILSTEESEAVVTPQEQSNTPCLSFPTLAGAEETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG81</accession>
    <name>A0A9P4PG81_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_36961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG81"/>
    <dbReference type="OrthoDB" id="3438382at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.70">
        <property type="entry name" value="Designed single chain three-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111730" checksum="C3493A3A5D7EA3A5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGU9</accession>
    <name>A0A9P4PGU9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_433436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGU9"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2443098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23952" checksum="C60D4C1A94C706C5" modified="2023-09-13" version="1">MATTAKEVKVPEPAHGAQGSAYNASDWEVPEESTATRKRLHLGSTSTRWAIADRFDRVLPPYKRYIGLKRRTFLFVLLGVLLAVIALAVGLGVGLGNKHKDQNLPLPSNSQTFTGDLTYYGPGLGACGIESNDDSPIVSVSHFTFDAVQTGSNPNQNPLCGKKIRARRTREDGKTVSVDLTVVDRCTGCQPTDIDVSPAMFDKLANHDLGRVDVTWAWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGW4</accession>
    <name>A0A9P4PGW4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGW4"/>
    <dbReference type="OrthoDB" id="3788032at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="421" mass="47111" checksum="D07F0248BAF2F540" modified="2023-09-13" version="1">MRNRLSEQLAEQRSFLGSRVALLAWPSRGFKGRRNRNLLTGEQGFNTKEETTLLYGALGIVKDARLRHSKASRHAVRRLVTSCSSVGCAGTPTTSHSATLNYPHCRILVSMPRTDLNHPTTRQSTTAMPYMLQLGNQQNNILKEGAQSHDTGTVNRVGREHAPLDSPEVGNKFSVPRCCANIEERTKSDSELVQIGFADANSEYRETIMNEKTVTPTREALDPRDSQLAKNWRLGFFQCPSFGESLFRPKRTRHDLDHNELDLILHAETGHQHAVLFQTPISHNRTAIISACFLLAAASAVYESSRPGPPHHFCVNAHNNHISSRLELLQHLTRSLAPPFVFTLAMAIVYHLNVGHRFQDFFMLVGLFLGVLGGMAKYRDLQDTALRVVPWGLIAALGASMAVHRAWEHRKEVLQIHVTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHK8</accession>
    <name>A0A9P4PHK8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_444756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHK8"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="190" mass="22000" checksum="3D70461F3906A9D3" modified="2023-09-13" version="1">MTPNTLRIRTSWEYVLLCYALQQPAGQDEPLRLSEEVVAPDTYGGELFGASFINKAFEEKLEHKLRHEIYLVENVFENNDKRRIDVNNPSATLPAVQIDCLRENPRKLFYQKRLQLRRSTAVARGAVLRALNKRHGPTRVSQCSYGFLMSEPYQPEIYEEHMICNARINKADGQRYVDETIRWVIQSGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI91</accession>
    <name>A0A9P4PI91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_473677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI91"/>
    <dbReference type="OrthoDB" id="3785858at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="192" mass="21722" checksum="4E0E5C411DBC3BD7" modified="2023-09-13" version="1">MAGYPGFNYIDSDKDFTDDVQRTMDAKFYGMTSEFANIHDGYIEKNHNASVVFGNGNNQQLPFSPQGNFEERVINYDAAAAYGRSANRPKSRVRRLVQLLPRLPPRVPSIPIPGAGYLGSILGKRRRDDCDDDWEHVVGPVDHPVKNLTNTNVHDWQRPPRKLRAWGLFQGKEDKSWTVDPRTGKRVQASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIE8</accession>
    <name>A0A9P4PIE8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tail specific protease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_45962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIE8"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040315539" description="Tail specific protease domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="169"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="2">
        <location>
            <begin position="367"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2443878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="81776" checksum="3B1A09E148A260FF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIL8</accession>
    <name>A0A9P4PIL8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIL8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="150" mass="16502" checksum="98B169C39B13F736" modified="2023-09-13" version="1">MECFEKVGRQQLTAKGAWRSLRGRKAEKPSSYLVKHGRPRHFKRLGIMKSVMGVHAFQSQFVLKACVARNAALWQQCAASLYAPFSREHVAGLVQATGIDRLSFANRSNALSDLRRKSTSHSQTAAYLSPVTRSTDTGPRALQAGGCLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIL9</accession>
    <name>A0A9P4PIL9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_513839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIL9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040547592" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="28"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2444735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="532" mass="59369" checksum="754A56DDB492D2E8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ39</accession>
    <name>A0A9P4PJ39_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_278019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2446020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ39"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="568" mass="63163" checksum="86BD2221394CE996" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJC3</accession>
    <name>A0A9P4PJC3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJC3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="167" mass="18745" checksum="F3B930A135478184" modified="2023-09-13" version="1">MASVHDVESADASPPRSPAESSISLPPRHSSFFDDGCGLCRLNSTKTLTIREILSASTRRCDWCEKMTMALSVYMAQQATHEDPSDHEEFFRPEDRVRMWRFGSFNWIMPFVSTSMSTRPTIEICLDRKTADIAETDVNTRDTGGGYLYKGSMYGLSVPWSTGSQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK43</accession>
    <name>A0A9P4PK43_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_361408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK43"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2444326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="114" mass="12334" checksum="C447B627BA331DB9" modified="2023-09-13" version="1">MGVTKTTINEGNGPSPNKGDQVTMLYTGWLKNADGSKGKEFDSTQKPGRGPFKTAIGVGRVIKAGWDEGVPQMKLGEKATLDITSDYAYGDQEFPGLIPKNSNLIFEVELQKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKR3</accession>
    <name>A0A9P4PKR3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_274444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKR3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="96" mass="10363" checksum="F46B8884245F3050" modified="2023-09-13" version="1">MSDTVLADFNPADEEDWNNPPGSNLIPAPHQIRLARFLGPLPSSHVPCSRPARPPPAPHPTPPTTSDPSRPQPASLAPRPGTDVRRQLSPLPVPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKR7</accession>
    <name>A0A9P4PKR7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_409131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKR7"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="7">
        <location>
            <begin position="132"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="339" mass="36990" checksum="3B9E64CEFAD2DDBF" modified="2023-09-13" version="1">MGSSAKKKKEKKKDFQKVKLKVGKTKAKAANHTNTSFKAKAIALKQQSISTHAPTVEAQCAHQLSLLNHKSDTQRRDSLAYLTTVISAHPPGLPLPQPASVIVPTVQRLVLDGSNGVRQQMLKLIQSLPKADIASHTDSLLLHTRAAMTHLSTDIRTFALEVLEWLLSVAGDEVVSCAGGWVKTLKCFLSLLGWQAEVGSKWSAMRTYGRGASDAKVQVKQMNTLAAFLRAGLMQPTATVTIGAGTGTFPLWQTEHHVLSERSNAFAHLNLFGSTRDEEAEMYEDREDRQRVFHELAEGAIAAGIEQSTKGGGELGRAGAYLRKAMKEGMVDFHRVDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL03</accession>
    <name>A0A9P4PL03_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-coenzyme A thioesteras-like protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_431350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL03"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF11">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04355)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="59"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="151" mass="16219" checksum="EC2F49BAF92C2A9D" modified="2023-09-13" version="1">MAAPANDPELLSFVEEYWAGRLPHSAIYQLVLSDVKFTHASKGVVRARVTLAKNHVNSHGGIHGSTSATFFDWVGGMAIAVWDKRSKTGVSTDIHVTYQSSAREGDEVEIEGIATKVGGTLAFTKCSIYKVVDGERGAVIADGSHTKFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLE2</accession>
    <name>A0A9P4PLE2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin interaction motif protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_254103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLE2"/>
    <dbReference type="OrthoDB" id="4489171at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="470"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="87703" checksum="F1E0A870A0C7E454" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM39</accession>
    <name>A0A9P4PM39_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_238009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM39"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040301252" evidence="3">
        <location>
            <begin position="21"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="404" mass="44494" checksum="48C75FA659A80C10" modified="2023-09-13" version="1">MVLLSTFLGTCLTVVATTAAAPTGTCAAPKPPPYSDIPTPGHELTGIPMPDDFHRFQRIYQKNVRASLPSGNCTKKNIGKRRSWDELDDATRIDYLRAVNCLAAKPALTDKKLAPGAVNRLDDFTYIHINQTNIIHGSGYLLPWHRMFLWQFEEAMRNECGYKGHLPYWDNARFSEDPTSSAVWSGSETGFGGNGVDLHVEPKTLVFPGLTKPFKLPMPGGTGGGCVTDGPFTNLTLSLGPVVKPFIDKNNTYGYEANPRCLARNFDPASSKGVLTWANATIIVSSHSIGQLRGTIEGLWHKDSHTYIGGEGADPFSTTNDPAFYLLHAQIDRLWAIWQGQDLKNREYAIDGNRTFLGIPLDYAPDLPPSLATIDDEMDMGLGFKPKTKEGMPMTKGNFCFIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMP4</accession>
    <name>A0A9P4PMP4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_252308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMP4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="167" mass="18350" checksum="0F53E2805EC2B11E" modified="2023-09-13" version="1">MQIPRTHRHGTLPCLTRKPNPTKQNSMHITPHTLLTSTSTACHVMSCHVHHIHHPRLPKRRYNAHRPCTMHPAAAPSTAPSGMFQPRGSAPHRTACRDPQRQRPHSNGAYPPSHSRRLGMCATPSCSCGVSRRGGQDRTGRWCVGRKRKSKSKSHAGPNPGIGRVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN02</accession>
    <name>A0A9P4PN02_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN02"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="72" mass="7492" checksum="E1B0E60783C13842" modified="2023-09-13" version="1">MLAVSTAGNSMTDAWAQFAKGGVAPAAGSDALMRDRRQDMVRDDEVPVCRDPTPARQGISSKKSPLGSSITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN56</accession>
    <name>A0A9P4PN56_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lytic polysaccharide monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_472592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN56"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF34">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040309053" evidence="5">
        <location>
            <begin position="21"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="6">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="263" mass="28543" checksum="5416A5F122F6E08D" modified="2023-09-13" version="1">MMMVPHSFFLLASWIPLALGHSMVYDIWANGRRYNGWNANGDLKAYPTDTPAWFTTNAGGGPLHPSDADQPQIICAKGGSNANMSAPVAAGADVRLRWWMVDQAWPVGHHGPILSYLASCNGPCASVNVTALKFVKLEERGWLNSSTYQEGYWASDEMIANNGTWTIRIPPKLAPGEYVLRHEIIALHVAFTSTGPYSLDGAEFYPQCVSLQVEGTGTKTITGGVDARTLYKGNEPGLTLNIHTSPEHMGYIIPGPPVWTGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN74</accession>
    <name>A0A9P4PN74_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_461190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN74"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF19">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="25"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="355" mass="38904" checksum="F221F2375020ECE2" modified="2023-09-13" version="1">MSSIPKQTRQWIVSKAPKTNVSLSGDDATFKLQTIDTPSINDGQVLVKLKYLSNDPAQRGWIQDGVLAERLYVSPVRQGDVMRSYGIGEIVQSKAENLKEGQLVSYMANWTDYRVLEAKEVNPIQEDKEAGIKATHFIGALGGPGLTAYYGLVKVAEAKAEDTVVISGAAGSTGSMAVQIAKHVLGCKRVIGIAGGAKKCEWVENLGADVCVDYKAADFEEKLIKATEGYADVYFDNVGGHILDTMLKRIQRYGRVAVCGSIATYNDPESTNLKNWFEVIANRIELKGFIVMDAYRDGNGQKMVDAVRNAVKEKKIKIEKQGETIVPTKFDDIPKTWTLLFEGGNQGKLVTELTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNJ5</accession>
    <name>A0A9P4PNJ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_519732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNJ5"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306:SF7">
        <property type="entry name" value="AHBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="72485" checksum="FC15684CEBB51532" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNR1</accession>
    <name>A0A9P4PNR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_253215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNR1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="127" mass="14298" checksum="862579486F00AE85" modified="2023-09-13" version="1">MAFLRLDHLPAPHLPHSTPILLYYFAYGTVCVYTRLNFSLPCEAPAPVAACSGSYSGAGLRCMLYASCLHATSLFGGWARFSLKSVGIDMLALCLRTKCIRFWRCVMMRPCLLVFISFSFCKKFRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNY9</accession>
    <name>A0A9P4PNY9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_429199</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNY9"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="178"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="295"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="402"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2447570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="495" mass="53900" checksum="3B87EA6EBD09C401" modified="2023-09-13" version="1">MDTEMANAQDARVDALWATLDTRNQGHLDLAALKKGLRKLDHPLKNADQILADVMKSVDTNGDGRISYNEFRTFVHETERELLALFKSIDIDRNGKISRQELQVALSRAGLAVPNSKLDVFFSEVDANNDGAISFEEWRDFLLFMPATAPNLHHVMSYYQGTHHVNPEGDVLLSDDTIYGLEYFVAGGIAGIVSRTSTAPLDRLKVYLIAQTSVTKEAVDAAKSGNVVRAFKNAWHPLAGATKELWQAGGMRSLYAGNGLNVVKVMPESAIKFGAYEAAKRAFATLEGHNDPAIIHSWSKFVAGGMAGMVSQLTIYPIDTLKFRMQCETVSGGLHGNRLIIATALKMWRQGGVAAYYRGVGMGLVGIFPYAALDLGTFEYLKRAITSHNARKRGCHEEDAAPGGFMTAAIGGFSGAFGASMVYPINLLRTRLQSQGTVLHPRTYTGIVDVTQQTIKGEGMRGLFKGLTPNLLKVVPAVSITYVVYDKSKAALGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPL4</accession>
    <name>A0A9P4PPL4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPL4"/>
    <dbReference type="OrthoDB" id="5238363at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="256" mass="29311" checksum="DED61213C7958728" modified="2023-09-13" version="1">MKAIIGLFTRLQPTTFRISYSPEYKTFLQHHAASDRLHPLYILRRREMAARKKEGLWWHVTSGIDLSRSGVVRTWCRRRLRNAFTEGLKGRGFDEFGRLVNVAMLRQHKGFERLSERDGGLSLEGSVQLRITPALVTTKYAEVRKETDATIDILLEGLKADSYWSHLSDPQLQSRALSQSKAPSRPRETASQVLPNTHSQQGQLSRFVLPSHAKAPSPKIRFQPTPSTPDSQKTFARRKTRQPRGNAKPRWQGWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ46</accession>
    <name>A0A9P4PQ46_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_379019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ46"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="336" mass="36766" checksum="B202E22D0701A5AD" modified="2023-09-13" version="1" fragment="single">MSEQATTIPQGSLVLITGVNGFVASHLAKQFLERGYRVRGTVRDLAKSSWLTSLFKAHTSTGAFELALVPDFNAPDAFDNAVKSVSAIAHVAAVTSSDPDPNNVIPVTIAGVQNLLEAATKEPSVREFLITSSLVSATLPIPGNTTHVGKDTWNEVVLEMAWAPPPYEPERGGIVYAASKVAAEKAFWEFVEQKKPHFTANAILPPMILGEPLHKSHAEVKAAYIRQLMTGDTAFLETMPATVAVDVKDLALLHVATILDPSVRNVRFNSWAHFCNYNDMLPIMRNRLPERKFIDDLPNLTVLSLSTDTTQQVELLKKWGTNGGWVSLKQTVEENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQU7</accession>
    <name>A0A9P4PQU7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF887-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_427796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQU7"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="69"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2449620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="389" mass="43910" checksum="77C33F9C7A499302" modified="2023-09-13" version="1">MHDPFPFPCPVWLRQLTEPFADYVSLKTLPLHIHEVLLAFSLYYAVHLVVAPLLSRYFFPRTYNSLSARTKLNWDVHIVSFVQSTVICVLALWVMVKDEERSEMNWAGRVHGYTGAGGLIQAFAGGYFLWDLVITLQNVSAFGPGMLAHAISALFVFSLGFRPFVNFYAPTFILYELSSPFLNIHWFCDKLNMTGSKLQLYNGILLLVTFFGCRLCWGSYQSVRVFSDVYRVISAGEFVLEDPELGKLNNGTTIDPSAIPTSDIMQFAGDRTVPLWLAASYLLSNFTLNGLNWFWFGKMIETIRKRFDPPLGTKKPEAKEAEKEQVLVEGISLQSPPSTPFAQTSGTDVNDYIGKVKVEKKSNHLEIEQMEIRKRTGEDGRPMSSARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQZ8</accession>
    <name>A0A9P4PQZ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_442433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQZ8"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040442441" description="nicotinamidase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="9">
        <location>
            <begin position="175"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="257" mass="28047" checksum="FBE53BC07ACC31A5" modified="2023-09-13" version="1">MGVNFLSVAATATLLLDASLVHAVPYSPSLHKGTALVLIDIQNDFINGSLNNPRAPAILPKVYKLLDDHDWPFIVASQDWHPKGHVSFASAHPKSQPGGSVQIPFVETPLKTENQSLYADHCVPGTWGAQLENGVQSRLWDLEGYRAPVHYIKKAQDHSVDSYSAFADNQYHRFTTLNSELSLHSISTIVITGLITSACVRGTSIDGIKLGYEVILIEDATESFSAEDKASAIAELEGWGVQVQNLTDWEGEHSTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR26</accession>
    <name>A0A9P4PR26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_354666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR26"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="247" mass="26179" checksum="F61E6B7637DC27F4" modified="2023-09-13" version="1">MSSKLIAIVAGVGAGTGAAVARKFASTYPVVLLARNPDNFKSLAEEINSSGGKAIGISTDVSDSKSVQNAVDAIKKEFGSDVAAAAAIFNASGGFVRKPFLELPEDGFTQSLIVSAKGGFLFSQATLPLLLEGVKQKSQHPPSLIFTGATASVKSSAQMSSFSTGKWALRALSQSLAKEFGPQGVHVSHAIIDGVIDIPRTKEWLKEAGPEAKLSADGIANDYWYLHTQPRTNFTWELDLRPAVEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRB8</accession>
    <name>A0A9P4PRB8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_428765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5363079at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04497">
        <property type="entry name" value="hPOT1_OB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="1540"/>
        </location>
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            <end position="432"/>
        </location>
    </feature>
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            <end position="483"/>
        </location>
    </feature>
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            <end position="606"/>
        </location>
    </feature>
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            <begin position="639"/>
            <end position="676"/>
        </location>
    </feature>
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            <begin position="720"/>
            <end position="846"/>
        </location>
    </feature>
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            <begin position="938"/>
            <end position="1263"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
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            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
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            <begin position="271"/>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
            <begin position="1564"/>
            <end position="1578"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1578" mass="170296" checksum="920D720455C58970" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRJ2</accession>
    <name>A0A9P4PRJ2_9PLEO</name>
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        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_380326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
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        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
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        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
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    </dbReference>
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        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2449994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="389" mass="42089" checksum="C24D83E2BF7F9D96" modified="2023-09-13" version="1">MASAPTPLRTALIGLSSSATTSWASAAHLPGLLSPIGREKLPITALLNSSVKAAQSAIATYQLSPETKAYGSPEDLANDPDVDLVICNTRVDKHFATILPSVKKGKDVFVEWPIAANLEDVETLVREAGKSGSRVAVGLQRRWAPPAVKLREIIKAGVDGKKLGKILSVDVRAYGGTNDRDIVPEGLAYFLDRKVGGNVVVIGNGHLFDTVLSVVGDLEPGAVSSKLQLQRPDVRVRDPSTNEIIKTVQSDVPDLVSLHGTLKHSSATLSYLFRRGQPFPGTPALTWTINFEHGEIRLVSPSGLNLELGEPVTIHVHWFDSDEVEEVKWEWNAEQTAIPPSARNVINTLVAFADRKAPGDGWVSLEDAANRARLIEGFLAEWEKSRKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRM2</accession>
    <name>A0A9P4PRM2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_428920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRM2"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF17">
        <property type="entry name" value="SEXUAL DEVELOPMENT REGULATOR VELC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="225"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="442" mass="49474" checksum="3A8F8469270F76DC" modified="2023-09-13" version="1">MTTETQKPPAFSPPSFLDYPQSRRLPPLNIPTAVPPSRPDFPFHSPVNHLPSILPGPPRHDLPHHPPSLPRHPAPVDKLLQPSSYTPPRPDPPYSPQQYGLSISPRTTYDSRGPRRLTDQRHPFEDTRSTHHPPPHHEQPYVLTSPVEPSQQRSYAPLPSPGYTPSYASSSTPFRGSVGSHSHRGSAPSSLGQLAYPDAPTTGPPPRQEPRAAPLPGSIPQPVYNDQLNLNYELVVRQQPIAARACGFGERDRRVIDPPPIIQLKVTNANNEPEEEELRYSLNVVHCTLWNADGTSEETALIQPDRRTTRRLMGQLVASPSVAKDEHDNEGCFFCFPDLSCRTHGRYRLRFVLMRIDPMNLHVGGFSPILTEVLSDVFTVYTAKDFPGMRPSSALTRALKLQGCNIQVKKGNEKALARKRLTQGQEHDHDEDDELGKRRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS08</accession>
    <name>A0A9P4PS08_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_469426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS08"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2449356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="561" mass="62355" checksum="93D936ED9D081A71" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSG6</accession>
    <name>A0A9P4PSG6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_427765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSG6"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="50"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="755" mass="84652" checksum="8A03CE4FD5BC2D6E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT93</accession>
    <name>A0A9P4PT93_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_428110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT93"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="87"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2450001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="172" mass="18721" checksum="EC4978230D46D372" modified="2023-09-13" version="1">MDCIIHASLLHCGARIAFTNHDSNPHLTRHPDPRFQIPPPHLHTRPSDSPNTATISFLRHFFTRAPSPTTMSATKTKVQSIIDENPVAVFSKSYCPYCRSAKQLLSDSGAKFYAIELDQVDDGSAIQSALADITGQSTVPNIFIGKQHIGGNSELQGKKKELTNLLKSAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTG7</accession>
    <name>A0A9P4PTG7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_441320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTG7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="427" mass="48343" checksum="C5ED228656E220E8" modified="2023-09-13" version="1">MPPKKDLSATTSGLVWSARHHEWLCIKGHAELVKKHVSARDKDEKVEFLVCSKNDCTSELRLTQAFLKKEVGPNPKMTAVLKRLRDEYSLEGGNGKNEEFPETLVAETDSEANDPSPNRQQVSRTATSNTRWKKTPSKTRRHSGRLSGRAAASVEPVVISDHESGQSDVFDLDLTEVESVFDTEVEEDQPTTVTKPNKHKRALVEENTSSYALDDEERPKQRLKTGSDELWKVPKGCKNTGRTILEVWMNDPLQVYNYRNMYRKGKLRSNGSWKDFEKACVKAGITSEFLDALHESNRPISDEELQRLRALKPRTKRSGPTSLTPLNSKDKTPMEAKARKISLIGSSSEEPREDATPSSYHRTARHLIGKKMKTSFEKCLDLDRTSYTADNDTIQYINKCMTIAFEVVAWQLARVDQDVLDSRMQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTN5</accession>
    <name>A0A9P4PTN5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_203568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTN5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="212" mass="23565" checksum="46D4783D293DDA86" modified="2023-09-13" version="1">MVERRRKPVSMLAGVVRQARRPGCSWEACPNDGSVVERRSCFGGGIHVQGAAMGITEKQKRGISLWAMVWCLLRGRSFLNVALANGMRGISPGFRLSHFHLPAGVPLSARQEAAQGTRITSQRRMLPSKRMLNVKLRVLNARPRGQWINSWAGVSQPTSVSCPQRTESLKPVLCNSVYDKRTRRRTDLPCTNEPAMKHKVSPDAGKSHKTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTS6</accession>
    <name>A0A9P4PTS6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_204461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTS6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="131" mass="15175" checksum="DDA05C341DAFCFD0" modified="2023-09-13" version="1">MAGRQALLAYLTLFIHSQRFLLYHFWTAVHICLSLYGTLLCSLSQQSENRTRSRCMLGVFRDNLRLLFVPTLANGRTCIDLSWDGAPIVFFFFNQPRASHMLLDGFLAEKNRLSRLNHNYTRPLKTCVTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTW0</accession>
    <name>A0A9P4PTW0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_405853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTW0"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="37"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2450102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="152" mass="16708" checksum="CF36B776793E51DC" modified="2023-09-13" version="1">MSDGEDNQSVVAAEEVEEVEVSADASAGKGQMSVLEALKGVLKLALIHDGLARGLREASKALDRRQAHMCVLNEACEEEAYKKLVVALCSEHKIPLIKVPDGKQLGEWAGLCQIDREGNPRKVVNCSCVVVRDWGEESQERSILLNYFQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV58</accession>
    <name>A0A9P4PV58_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_146852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV58"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040510368" description="Secreted protein" evidence="2">
        <location>
            <begin position="35"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32770" checksum="198BBDD3F8025BAD" modified="2023-09-13" version="1">MCIHILFPSHVWSIAQQATCRVALLCSMLWCASAAVSRTNVPPACTALHSTAQVMCCKSFSPLPSIPSIPSISMSSVRTRFACSPARTHALPPMMPLDYRYGDNSRPSPSAKSENTNGQRKTDEQVLRCIRIGVVIRCLTSSTISTFQHHPHIPSSALGKHYFPSRSHQYPILKQVKPRKYTHIKASPAQLGCKAAKAVGPKQRPDSPQNEASTAKKRKLHAPSHASYHVPCQVNKHYVPRLSRRMLPSQFANFNADSMQGFDKRNFERVYNWIQIPAWSWKISALWAQGDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVJ8</accession>
    <name>A0A9P4PVJ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_467855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVJ8"/>
    <dbReference type="OrthoDB" id="3786030at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="611" mass="70216" checksum="24A35CEF6135A41A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVL2</accession>
    <name>A0A9P4PVL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_439621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVL2"/>
    <dbReference type="OrthoDB" id="3783916at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="169" mass="18647" checksum="9B9F01978C4432E5" modified="2023-09-13" version="1">MGMSNRPLEAASNAGIFTPHDGTQHAAKSSESIHAPLANTMRESPLRNEDTSLPKLSLRKKVLRTLKRVSNKLHRVKSQPPTAATESIQTEGIVFRLLSHVPANDFTSENEDENDAVEGEERQSRTGMDLGTNEGMIGEFREAVTHTTAVDMPYDIWNATVLRSKSHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVN9</accession>
    <name>A0A9P4PVN9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_153400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVN9"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2451140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="700" mass="77533" checksum="A1195369C8C269E3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVS5</accession>
    <name>A0A9P4PVS5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_427355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVS5"/>
    <dbReference type="OrthoDB" id="2519291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="12"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="142" mass="15998" checksum="211603ABB403D5A5" modified="2023-09-13" version="1">MPYKCLTFIHRKPTTTPTAFRTAWETHMQLLMALTHPHQPLESVRHYPARTDSAIAQRAPVSARPADANAPLVLLGDADLVTWDCLSECTYRDELHFQQFYAMLSEKGVGERIAASEERASDMGRLKVVVVGETVVDRFEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW17</accession>
    <name>A0A9P4PW17_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_351827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW17"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF5">
        <property type="entry name" value="UDP-GLUCOSE,STEROL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="247"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="566"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2449816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1188" mass="131056" checksum="DA62A44B763B3AD5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXB9</accession>
    <name>A0A9P4PXB9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_349314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXB9"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="62"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="169" mass="18497" checksum="35301C9E00F4DB0B" modified="2023-09-13" version="1">MVATRAAARFSTPCTTPQRAIARHVTSVQVGSAQQRHHSSFPSDRRSKVYEFKDVLSLVENPNDSTLLIDVREPAEFAANSIPTSLNVPITSQPDALLLSEEDFEDRFGFQKPPREKMVVFFCKAGVRSSAAAQLAKLAGYTKVGEYRGSWLDWERNGGPGTTSGPGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXT8</accession>
    <name>A0A9P4PXT8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_516073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXT8"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2452222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="245" mass="27033" checksum="50C4818F31CE25CA" modified="2023-09-13" version="1">MASFFGTIGSERTRDTFIEKTTNLFASLNPFASRTSTPASRLFARANPSTLVLLIGLDESGKSTLLREYLSPGPEGVQTLTPRAHIFLEKLRVGPTIYQAYDIGGCRPTYFMEFEEELFKRADAVIYLVDAADRDRIMEAREELMMHGLTANNGGMRQGVPLLVLATKIDLENARRPDQIETYFLDNITTSIGDRPTKVAGVNLKTGKGVLDALSWLSDTLLNKSSSQLSFGTEKVGLSEKSELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXZ2</accession>
    <name>A0A9P4PXZ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_375444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXZ2"/>
    <dbReference type="OrthoDB" id="5286775at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="395" mass="45674" checksum="92FDB50896312FC1" modified="2023-09-13" version="1">MPFLRTVSDRVWDYISPRKTQQRREKPFKVPALPVRSKLPERAFPETTPRSKVEHWSPKTPASPTDLDETLLPPSPPTSLHRYEEDFDGDTLVHDSVEDEHFKDPESDAYDANDATMVVDDGQYMEMRKPVDRTNEQLRQEIQCRELRQAGWSEDSVFMFQKLNMRGFEPLLPNPWKKDFVTLPLNLFTPNDNMAFIKADGLSDFRAQYALNQLFTVGGLARDAVLTKARKRTAERHIVQSVKKYSQWALRDGGMRRTQKGIKLFDTVACPKNVPSYVCEQKMIRKLHKLYRKWDDEMLSFDKTGLVAAPEEVPTLYGIIASHTVMAFVSYVLPTEPNPKGSLRTIAIFDFGKEGYDVWNSLAVAIFVIHCRNRMQELREFLPEPVVVHRRDPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYJ0</accession>
    <name>A0A9P4PYJ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_425757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYJ0"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="53"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="332" mass="36471" checksum="B4D8C4D8543B3F45" modified="2023-09-13" version="1">MFSRLSQIARHLSRPVPNYAHRAAASLQATPYTSSIMAATSSTQTKGLIHTAACLIIGDEVLGGKTVDTNSAYLAKFCFSAGINLKRIEVIADDESEIVEAVRRMSKNYDFVVTSGGIGPTHDDITYQSIAKAFDLPLKQHDAAFERMKRLSKPHPSQPNFDWNTPSAALTAKKRMIILPYNDSIPDEEQVIFIDDSLWVPVACINGNVHILPGVPRLFEKMLDGLKPTLLPRLADPEGKGVLRILISTPLPESAVAEYLTQLAARAEPKGVKVGSYPRWGKENNTVTLVGRDVEFMESIVVEVEKAVQGHRVRVEGEDDPEEADPQKTEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYL8</accession>
    <name>A0A9P4PYL8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_425764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYL8"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040400841" evidence="2">
        <location>
            <begin position="27"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="373" mass="41126" checksum="7487A99463A45584" modified="2023-09-13" version="1">MALQPLWNIFSIAVLLGPAILKFVDASPTLSRRAQVQYSTAELHDSYDYVIVGGGTSGLVVANRLSEDPSKKVLVIEIGYIADESCIWMPSNIHIQNNTACLKHRFNISSVPQTEIINQAVYRYAIGAVVGGSSAVNGMVFDRGSKADYDAWEELGNPGWGWDGLFLYFKKSVDFTAPSVEAAKRFGYTWDEEAWGDGPVQASYPPFQWETVKTSWDAWADMDIPLPKEHALGNAVGRFWVPSSEDPVSRTRSYARYAYYDPIVTRPNYHLLVGHKAESLVLSPENDVEGVVFYQRDNPGEKKTMKAKKEVVLAAGAVHSPQILQLSGIGPKAVLEAANIGIKVDVPGVGNNFQDHPQVYLTCICKLRKLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U3U3</accession>
    <name>A0A9P4U3U3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_506528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U3U3"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040507826" evidence="4">
        <location>
            <begin position="23"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="46"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="420"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="548"/>
            <end position="549"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2437239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="567" mass="60591" checksum="1D89213B56DF1184" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U420</accession>
    <name>A0A9P4U420_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_450045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U420"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2437479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="168" mass="19153" checksum="6B23E6A9D7A512FE" modified="2023-09-13" version="1">MQWRCWAEKEGVEVQKYHANGNAYGVFWIPTAMDSDRNYNRRFSGIEHWLQVPPRPNYHLITEHRVVKVNFEKFNWFQKAISLGVQLRLCNGAFIIKARKEIILSASTVRTPQILQLSGAGPREVLKTANIDAITPECASGARLSPGPPVVDYRLLSNPADLELHLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U533</accession>
    <name>A0A9P4U533_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_467775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001517">
        <property type="protein sequence ID" value="KAF2437301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U533"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2437301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="311" mass="33397" checksum="4444B6B3382A7F2E" modified="2023-09-13" version="1">MSKQYLTLHTLSDAHPSDVFALAPTTKSILSASGSSTIHIHDTTQADFPLLQSLEGVHPLGIHHLATAREARRAASAGFEGRVKIWSEGEDGTWKADGEISDQLKAGDVWAIALSADGKYLACSSINGKINVWSLAEEGKPKIRDYETKGSFGMCVDLSRDGRFTASGHENGSIYVFDNDTGRLTHSLAGLVKPVRSVAFSPSTTLLAAAGDSRTIALYDVKSGEQIANLAGHGGWVLTLDWSDTGEYLLSGSHDGKAKIWRIETRQCVATHAHGDKPLWTAKWLPKSTRSEMFALGGGNNAISFYREAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5R2</accession>
    <name>A0A9P4U5R2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_437864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001517">
        <property type="protein sequence ID" value="KAF2437257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5R2"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF28">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040460405" evidence="5">
        <location>
            <begin position="24"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2437257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="487" mass="52837" checksum="A75E0D1BED148A29" modified="2023-09-13" version="1">MSSLSSVFFLGAILLAHLSHCLASPAVTCQSLSSTLPGKVFYPGSDAYNSSINSYTYVNDRLLPACIVGPRSTGDVVSSVKILGKYPSTHFAIRGGGHSSNTNFSNTAGGVTIDMRAIKAVTINEGRDTVSVGAGALWRDVYAKTDPRNISVLGGRIATVGVGGLTSGGGISYFSPSRGWVCDGVANFEIALSSGKLVNANVDSNPDLFAALKGGQNNFGIITRFDLKTFVIKPFWGGTISYNNSTDDAILAAFTKHKTPKNYDQEMSIVQNMAYDSSTGAFNGITAVYYTTGQANPKQLKFYTDIKPQLSNTMRLSKPGDFAQELEDFGVPDEYTLAAVTSFRFSPTVIAETHAKWKAWVLKIGKIANLTAVVNLQSLPPPPRSPRTPNSFGFSPNSHPEKDLVPFTLSINYKDASATGALTKEIRRFIKEIDRPESFKYMNYAGWFQDPIKSFGAVQVQKLRSVSRKYDSTQMFQKQVVGGFKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6N1</accession>
    <name>A0A9P4U6N1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pantetheine-phosphate adenylyltransferase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_99005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6N1"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="406" mass="44653" checksum="80E04D95D3C06C0D" modified="2023-09-13" version="1">MPPTQHPLPLRALLLLPPAPSPPTYAALKAAYSAPLLTVLQQLARSPERAHERAILEIALPSPHLYGQLDAPRGRFYAATESLVAGLYKLVCILAAQNAIDTEDAEGVDARIILVAYPRNGKLDEPAPESTPEHETQGPAVDLYTLARSPRSWEHIFSVQCEEGEGLLKNFLALSGVQRPVQRVRGGIVTVESAAPSESQVSPVNHRSVAVGGTFDHMHIGHKLLLTMFAFVLGRRHSHDGQAPSVLTVGITGDELLKNKKYAEYLESWHDRQQGVHDFLTSVIYFGQPDDRRIGIEELNEPGPNGHAVHVTYPFGLLIKYVEIWDPFGPTITDDAITALVLSLETRSGGKAVNSKRAENGWGELEVFEVSVLDASEEECVDETFQSKLSSTEIRRMRSERSQSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7H4</accession>
    <name>A0A9P4U7H4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_525697</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="68"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="950"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2405"/>
            <end position="2488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="950"/>
            <end position="1078"/>
        </location>
    </feature>
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        <location>
            <begin position="1088"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="982"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2439163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="2495" mass="271935" checksum="53B74169CF93EAB6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8D2</accession>
    <name>A0A9P4U8D2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_395449</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PMF1/Nnf1"/>
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    <dbReference type="PANTHER" id="PTHR15459:SF2">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B561"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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            <begin position="63"/>
            <end position="88"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
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            <end position="121"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="133"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="173"/>
            <end position="194"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="18">
        <location>
            <begin position="30"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
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            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
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            <end position="435"/>
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
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            <end position="667"/>
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="688"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="368"/>
            <end position="392"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="501"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="585"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2440751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="771" mass="83903" checksum="E8A1F4D8BF38F56F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8T7</accession>
    <name>A0A9P4U8T7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_92817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8T7"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="227" mass="25208" checksum="6D5149143902E442" modified="2023-09-13" version="1">MKPVASPPHLSAAEFHTACTTLVNSFNALQDAPSKAKWLDISLDPGENMLRIAKELSVTTTSHQEPNSHDGPEIEDDDDDERLHSTANNTPLIHYDVLLSSSYTVPVLYFYISDALHRYPPTMDTLYMHIIAPEYVDQTKDVGVLGGITITDHPIFNRPVFFIHPCRTAEVIQASLGGRDISSFEYLLMWIGAMGKSVALDVQVDLVLNAREMLQGPDETIEPFAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U988</accession>
    <name>A0A9P4U988_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_524778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U988"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="276" mass="30796" checksum="BD1AA66094D94A13" modified="2023-09-13" version="1">MSSGPYLHGHHASVLRSHSWRTVDNSCPHLLPHLNNPSLRILDAGCGPGTISVDLAARIPLGSVLAIDPSVEVIEKARRHAEEKGVTNVRFEVGDIFNWNAIEGIEEGGFDIVHAHQVLQHLQDPLCAMKEMKKLTRKGGIVAVRDCDFSAMNHYPPHEGMSKWLDLYRSTAKSIKCDPDIGKRLHAIAMQAGFLRDDIDVSVSAWTFSTPAERAWWCGLWAERSTKSDYKARVLESGLGTEEDLEEIARTWREMEGKEDGWFAVINGEVVAHNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9B1</accession>
    <name>A0A9P4U9B1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_59729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9B1"/>
    <dbReference type="OrthoDB" id="3790550at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="485" mass="53256" checksum="D3894A919127C4F0" modified="2023-09-13" version="1">MATPSHFASVFKSVREAQARRHSATVSQDEIAPDDYPTFTRPLSPQLDESKRYTHDPPKRKRTNPWSFQRNPNAPESGDDCDRPLSRRLSRKASNVFHKFTPQTTHGNASTAPAQEFPGAPEEHAAKRLHVTAEQPERRSSLQKLKDYILDKVRKDSATSTKPLLPAHPLDEDDHAMGLWQCSPPKHSQSLYTADPDIIYMTGALPANDPSRNSQEHSENISLDPSVNPILTESRRRKASTAAASIDSADVPFSQGVAVNITGYSPPPTPKNRPSYHYPKISISNSSTCHNYPRRPRAGPSSSGKYINIAVAGSSARHVVAPWEEIEQASPSTSTSTSTSTIGVLPSLSSVESASHVSLPTFALPSTPTNASTIALHTPSRPQSPTQGTQSMDVRTPESCDSSRNSPSPAAKFLDVPRIDTRPSTAADSVAEQELRLRRLGSLRSEASVLEGMEGMEGFEFVERAVGWMGEEEEERGRGWRKRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9B6</accession>
    <name>A0A9P4U9B6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_465568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9B6"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="701"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2440887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1172" mass="131613" checksum="0327B0BF0706B07E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9M5</accession>
    <name>A0A9P4U9M5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_473834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9M5"/>
    <dbReference type="OrthoDB" id="10580954at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="241" mass="26991" checksum="6DA7D7A4455FDA3D" modified="2023-09-13" version="1">MSCLPVKIELLSVALTTLGKSTTRVGICHRERIPFIYLRKDIFFARSTPDTIFCLAISPILQERLDLGFEEAHKMARAMRKVSSEEQQKRYAPMAERGGERWEQNQQMVQGGDTVNQVLDELLRTNIVRDAQAVRPPHVVRGALKPVLPYGHPWLDEDDTELGKDGGDTSASRMAIPASSPVNTRILQATSENQRNNRKTLNEPIDLTTQTLRTRQFDPSQASTQAGKSSSNAGIPRDLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9Y9</accession>
    <name>A0A9P4U9Y9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_487845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9Y9"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF108">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="44"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2442625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="260" mass="28960" checksum="DCBD5D5FF16F2BE0" modified="2023-09-13" version="1">MAVTPAAAPPPGLGSDFDHPPSKAQTVYIVMSVCLGLVTLLVAIRIYTRARITKSLWWDDWTSLLAWVFFIALLRVTFGAVENGGGVDMWNVPKSKYTHFITYWNNIMIMARVDITLAKVAILLLYLRIFVPHQTGSRQMWFWIWFMVVFNVVYCLVLILLIQLQCVGHKTPQANGSCLDQHVLLITASAINVITEVAILIVAIVAVWGLRMPIGKKVACVAVLSFGSAGIAFSLARLMWQSLTKNTNPTMYNMTVIMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA05</accession>
    <name>A0A9P4UA05_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_23850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA05"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="515" mass="57882" checksum="18A8A2CBABB249B3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBJ3</accession>
    <name>A0A9P4UBJ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_358237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBJ3"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000617">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000002">
        <property type="entry name" value="Trehalose-6-phosphate synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="960" mass="106961" checksum="543097D9C16C6707" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBR1</accession>
    <name>A0A9P4UBR1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_485868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBR1"/>
    <dbReference type="OrthoDB" id="3791920at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36846" checksum="DA2325100F9D3852" modified="2023-09-13" version="1">MSSQGSVASDFMSSSQTPIFNQESVQDTHNVPNPNAGSSYRKRKRGSSPDVLANSSQVTVTSSHKRKTPQTTPTKPVPSIPTSRYLQLQARGTDEVFKMNEATLAKTSDLFKYKLYHSTRPSSSPAPAPGANDNPPETDQPPSSQPPNTLIPSTPISPASPVVRLNTTSQALFLYCLWVVAPPDRLSLYLDSTIPRPSYTFTIYLYEAFLLALELKDTTFLHHLITVILKDEEAGWPGEAEIAWVYENTGPGHALRRFVVDCTLTWADEAVGKWGAWVRRTPAEFVVDVSCRMLELGKGKWGWMKTNVATKYTCGVWWSEDYLDRALEGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCW6</accession>
    <name>A0A9P4UCW6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_268262</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCW6"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040147827" description="chitinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="15">
        <location>
            <begin position="28"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2445580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="363" mass="38617" checksum="ACAEB71A31CFF752" modified="2023-09-13" version="1">MLRTLRAVAACALLSAPALAQTYTNCNPTESSSCPPDSALGKTVNIDFTSASDSFTAEGNPTYGSDGASFTVAKQGDSPKITSKWYLMFGQVDIELQAAAGQGIVSSFFLQSDCLDEIDWEWLGGDNGQVQSNYFGKGNTATHDRGAFHANPGNHDGFQKYTIIWTSEQIAWQINGQTVRTLIPDNAKGQYPQTPMAIKIGAWAGGDPNNEQGTIDWAGGLTDYSKGPYTMKVKNLKVQDYSTGTTYTYGDTSGTWQSIKSNGGTVNSGGTPVKEDAPSITSAAVGAPLPFTPHTTSPYTRPSVYPWVPDTTVVTVPTTTYGNYPGLPSGWSVSDSGKVIPPSQAPVSKHLLLPLPPLSTRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD29</accession>
    <name>A0A9P4UD29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P171DRAFT_463215</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD29"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="40"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="202"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="491"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="19">
        <location>
            <begin position="596"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="702"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1083"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2445881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1208" mass="135939" checksum="78A62EDF944DD1E4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEI5</accession>
    <name>A0A9P4UEI5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_341977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEI5"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18138" checksum="9C77D5E602DFDCCC" modified="2023-09-13" version="1" fragment="single">MPVTFSSVGDIIAVCILVKDCVDALNEPRGSAAEYQAVVRELCILEKALLKVGILSSTHATTPELIRMKNDVSRFRAEVVAYSISIDQLLAAATMLVLDPYSAHTIKAQSEKITNALVKQDKTLRDMQARLSEVDKCVSAGNSLLLKIAKVARTDWLMHLGQELKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UER1</accession>
    <name>A0A9P4UER1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_470667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UER1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30676" checksum="97EE23DCA3D2C57D" modified="2023-09-13" version="1">MRFSFTQGYRRVDQEEVRNSEKASRTSSEEFSVSESHIISNWTVWRRWLPWALVAVLTATNWYSWVRGQSQAATDAIYSPASSAIKYKNVIFQAGIDSDTSPYQGSPSKELDHEWEELHKYGVSRIPMSDAAQLANRTSPIPGDEGHYVVILEVFHQLHCLQHVRRRLFWNETTQGSPDEVEALSMKHLDHCIDSIRQSLMCSADVTPLPYVWWRKYDQLMPATAVTHTCRDFEAIRDWAKEHRAGTVDKHVQVHDPLGDQVVYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEV9</accession>
    <name>A0A9P4UEV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_429476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEV9"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="338" mass="36849" checksum="EF04C5C1573067C0" modified="2023-09-13" version="1">MADYNAPEFKRYAAVHEKPKGAGDSRPTALQIVKDNELEGKLAGKVVLITGCSSGIGIETARAMKATGAHVFATARDLNKGKKALADILEPGKLDLELLDLNSLASVRSFAKSFLSKTNNQLNILINNAGIMAIPEEKTEDGFEKQFGTNHLAHFLLFQLLKPALLSSATPEFHSRVVSVSSLGHRYNNIDLDNIMLENGTYEPNRAYAHSKIGNIYLANEIERRYGSQGLHANSLHPGGIWTGLQDHLDTSAWRASPEINNYMKSGAQGAATTVWSAVGKCWEGKGGKYLDNCQIAPPVPEDAEISASGYAAWAYDEEAEKRLWSMSNKFVGLPEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEZ0</accession>
    <name>A0A9P4UEZ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 69</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_350995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEZ0"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="37884" checksum="1B557FBB9C760CBF" modified="2023-09-13" version="1">MLRTGASRLALRTFPAPAVRAAPSFRIASPAAKWATQFSSVASKRPQAFQLAQLKPTQAAVLRRALSGERKQAEARYAKEEIKPTPELVSSTSSIHPIVGEVGGEPAHQEVDMSAGIKSDLNTIKETFNLSEVPRQAYYIGLAGVLPYLGTSISTVVCAYEINHAVAGYGYLMSANTATTLLHILEPLQVGYGAVILSFLGAIHWGLEFAGYGGRHGYSRYAIGVVAPAVAWPTVLMPVEYALITQFMAFTLLYYVDTRATYRGWTPPWYAIYRFVLTFIVGTSIVVSLIGRGEVSDQVGRMPGAVDRMKALGGPEAQATMSREEEGIRAQQALAGEGSKSEGEDESEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG89</accession>
    <name>A0A9P4UG89_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_518366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG89"/>
    <dbReference type="OrthoDB" id="3800160at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="339" mass="39697" checksum="25C81F66EB97DF66" modified="2023-09-13" version="1">MPSSPYRQYFIHHEWVRDANANFGVFRTLCDYRHPIDRDELWKLGRNRLRQMSNEITDCVNFHCPNPRCEAARGPKSHGRVMETMHRIFYLINDMGTVTSVGIVGIIGARRSSTTTHVVQNVLPQERHRTVVEEHVFQPPAIHETETRTWVHQGGRTYLAETKTTTRDGSGPVVEEAASDSEDGGKRGKKKSGRRMIKERGESSDEEKGKRRRSRERGGDRHRSRSRDRGQDRHRSKSRDRGHGRHRSKDTRASSSHDKHSDRHGEHDRRRSKSKDHGRHESSKSKDKDKDRRKDDKRSRSRERSRHRDHRDKREYEESEREYDSSPSRRSSSVASRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGT8</accession>
    <name>A0A9P4UGT8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_428051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGT8"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26121">
        <property type="entry name" value="HTH_CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="250"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2449931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="375" mass="41098" checksum="680A3D9EB77E942B" modified="2023-09-13" version="1">MAPIDPTAALPTELVNLLALHSSFLTALSLHFIHNGTGSPIDLRDLTEAITSVWRHRKVTYDDLRLCVGVLGAGPAARNNPFRLSDYGRGKICLEVSEEYKMQTGLSQRHEEALKVMFMESLDHLWRQWSATGQTPQKMSSRPIAAPKKRGRGRPARSDPTQSSIQTFIDEPSLTKFIAQLPHAEITTCESLTAIAPLQEKGRKRLREFKDSVQQGRAVKKTRETTGKENAPAHPAQTRMTDFTSVRKTNLLDRILAKEAAAACGPKPLTPAELQRKAALQRSEDVLSVISLLCASKGSGLRISFSINALLQSLQTSIRTPISKEEALKCIEVLASEVTPGYVNVVRMGALSSVVVNQGMRPTDVKGRLVALGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHX9</accession>
    <name>A0A9P4UHX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_204231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHX9"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000047">
        <property type="entry name" value="Acetyltransferase, GNAT family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF2">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="233" mass="26465" checksum="985C81936EEC0255" modified="2023-09-13" version="1">MSTPTSNDEKFGPLVPDTPANPPTYDIKLTGHHVTIVPVHPIHAEALYAQVSGPSNASLFDYLFDDPPESLSAFRASLAKKAETTNPWTYTILLNTTSQPVGLASLMRMELPNRTIEIGSILYTPTLQRTPAATEVQYLFASYVFDTLRFRRYEWKCNDLNKPSIRAAKRLGFVYEGTFRQHMIARGRNRDTAWFAMLDGEWEGVKRGFEGWLAEGNFEQGVQKRRLEEFREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI73</accession>
    <name>A0A9P4UI73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_440424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UI73"/>
    <dbReference type="OrthoDB" id="3800937at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="387" mass="43931" checksum="DD27A30B6F785139" modified="2023-09-13" version="1">MVNPKRKSQYDVDGRDVKKFRQSPPSAYRQSHDGKHQNKRGGRAMTQQPHTREQISEQLHQVPRHLVAQTMQQIQQKQQMLGSLQQHGLPQRAQQQQSEELKVEKQEHKPVSFVPYSALKIPILSSTNIDHSFNLTLENEQWDSTAWKHYYCAIAMIKTGIGREQLGLPTAKEGHGSPVTIDYVDLYLDLSDGKVYVAASERGLVTVLEYLKLSDIAVERKLRFTGRTPAWAKAVFDAAETRYVTETFQDIPLPVRSEVQVLNVLSLPLAPASLWGSMYSAYLKQVIQFPLEYTTKDREFAMVKGRPGPLSAAELKHVLALPEKDPSPQELGEALFKQAQECDRNTLDLQMTKSRDDYLKECGYMYGKTGNERIVFGGVDSEQCVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJK2</accession>
    <name>A0A9P4UJK2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_5611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJK2"/>
    <dbReference type="OrthoDB" id="5425848at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF10">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040295290" evidence="3">
        <location>
            <begin position="25"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="373" mass="38572" checksum="EB103FF486EAC1D9" modified="2023-09-13" version="1">MLFFKAPAAVLSLLALSFLPSASATLYPSPTAPARLNDFARLKLALAKRQNACDGTPCGYEDAYCCTGGQQCFTDANMMALCTAGDGGWIYSTFYYTAAETVTKASIWSTYIGTNPTGSACRSSDQCGTACCDSGEWCADASNNRCQVIGGGSAGSPGVTGTGTNPSAPVRPTSNGVIVITATGSATATVAFTTPIPTGVNGTLVEQNSGGGGLSGGAIAGIVIGVIAGIILLLLICAYCCAKALFDGILAMVGLGKKKKHTHEETTYIEEHHSGVAAGGRRWHGQAGSARPSRPPKKESSGLGKMLGVGAGVAALGALLGMKKKNDRKQYDDKSTTITDSSYYYSDYTSTSSASSDDRRTRHTRQSSRPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4Y9</accession>
    <name>A0A9P4P4Y9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor SF3b 155 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Spliceosome-associated protein 155</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_373738</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4Y9"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000303">
        <property type="entry name" value="splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="208"/>
            <end position="326"/>
        </location>
    </feature>
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            <begin position="568"/>
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        </location>
    </feature>
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            <begin position="968"/>
            <end position="1046"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="36"/>
        </location>
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        </location>
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        </location>
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        </source>
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        </source>
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        </source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4P5L5_9PLEO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Kuo A."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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            <end position="460"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="732"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="742" mass="82180" checksum="8499D6B159A0238B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6V4</accession>
    <name>A0A9P4P6V4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="228" mass="24989" checksum="82C2F562FE26122A" modified="2023-09-13" version="1">MAGWRKLKDIGCEEGIVAVAYDESKTAFNRRIHQFSMTDGAAVFMNMHLRDPDGDQPGRAQVFAGVYRKLTSRDPKDAWTSGQWMTERTGGSDVSGTETVAHRLTPEEINRKTQEGGHTNAVGMPLGPWKIDGFKWFSSATDSEISVLLPAMKAQISVASVHGLRNCMECLGEVGYCENNDDGGLLNIAISLSIRYGRVRSAAWLKTVRVILDKRLGNGDVVANIFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6Z7</accession>
    <name>A0A9P4P6Z7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_437594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10011777at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABM_dom"/>
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        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="112" mass="12895" checksum="7F2D2EDB7418AAC8" modified="2023-09-13" version="1">MASAYKDECEIVATLTPKPGKLDRVVELLTNLTTAVKANEPGVFSFHLYKDFDRESGDEELVLVEKYADKEAYDYHSERPEFKAMHKIFREEELMQKPIVIKSVKPVVGFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P793</accession>
    <name>A0A9P4P793_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_369236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4821403at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="209" mass="23116" checksum="D065F3E5CA1372F7" modified="2023-09-13" version="1" fragment="single">VKIRDPPTFSDAKPNPSWKPPPTGWIFKPWYQVLTSNTQVSQLRNFQWDPTPVTSSNPNGPINDLSSFQIPGNNTVFTSYGVATPNPNYVAVYDYRGTGILQNATSQYSWLGWGCDGFGNSYYVSYSTAAEASGTPAGIDFMSLFDSGLDEATKNKVVEVLKQSKSEEIRKIAETFIPNVQDGGRRGKRRIRECNDECKTNKNLVGVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7E6</accession>
    <name>A0A9P4P7E6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_526266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7E6"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000035">
        <property type="entry name" value="SH3 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="411"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="830"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="941"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="967"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1112" mass="120529" checksum="168B5B2B53CCFF8E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7V1</accession>
    <name>A0A9P4P7V1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_116730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7V1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="198" mass="21298" checksum="1CBF017445EB3666" modified="2023-09-13" version="1">MGIALMNMSACALHCKGGSRPTAYLPAFRPPGPISRQTDRQCNTTAPQRRELREASRARGLRRPPPRVRARVLFGVQSTWLPAFCAPRGRSPPCATAAAACESLTSAVGVGVVPEGTPSWGARWGLAFSCAISDFACVGEADMGVIGGRVDAERALQMCKVRMRRACPYPRAACRTDEMGRPVRGKWPIGWRSGGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P940</accession>
    <name>A0A9P4P940_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_490850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P940"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="57"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="153"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="476" mass="53450" checksum="C4E6483403FC6D04" modified="2023-09-13" version="1">MIDGTSIRRAISKCDLEHAGVCHSIQDPWAKLTPVAQIIVIDVDKQSLSFKLGSCRYVALSYVWGAQNAGQRVLGNRSGQNKFTSQTTTGNFSQLCQSGAFRKLAGLGLLPATVRDSMLVVRHLGLRYLWDYQARARAMVVDFQAMEEHISKVDRFCIIQDDPNHKHSQIQAMAAIYSNSYFTIAACEGEHNDSGLHGVGRHRPRKDPFHRFEFNDNCRIVAPAKSHRPHRKIRLLQARVDTVSWICKQTLENEIGLELPQNVGIERLHSVFSAQPDIYAYATAVQAYSSRSLTYAEDTLVAFSCIMVVMGKSMAGGILFGLLEMFFDGVLLWEPSAMGTLTRRPGACADGWEGKITTSMWKLVYDYDLDKDGSCVKRHRSSVYLTPIARMYKTDEATQQRTEIRSKFLVSTPRASAGEEVSYERLGERFRFQAIPTQSLSAGDNGYSPILEFRARRLASSRLWRESNTSADIPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA99</accession>
    <name>A0A9P4PA99_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_366577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA99"/>
    <dbReference type="OrthoDB" id="3768628at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="263" mass="29268" checksum="9A32CB76A19125C4" modified="2023-09-13" version="1">MAALKSDADRTHASKTAGSPLARATREFEALVLRFETRLLRARDVDGRGRRDDVRREACTLALAELGARHTKLQIRRSLSAAEAQGRRVEQRLHAARQEDDDDAAHDDLRAIHHGYFRLYSTELFDMLGQPVDLRLGTVRFHHCHPAPPPPAAHAPDQGPVSLELALGSSFFVADALETLPFHAFKVPRTPSLQNRGILSRKPDDHGAFPGYDSWLLFTFLGHGCLKLEVPIEMCADVYGGPLAGRENEEVHFWGVFVDDDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAR2</accession>
    <name>A0A9P4PAR2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_476788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAR2"/>
    <dbReference type="OrthoDB" id="3642826at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040419257" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1182" mass="117465" checksum="109F653AB01A3DF6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAW4</accession>
    <name>A0A9P4PAW4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_525073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAW4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55993" checksum="51EDE13ABF6A8F02" modified="2023-09-13" version="1">MPQLLDLANELLIPIFEHYAQIESFQYVISARKTCRRISVLITHEILAATPIEKLVHSASNAPTQLIRKYPAYHLRQHTLHFRGANPHLPALVNQVVVNLLQNVPDGSDLENICGQYVEGLVLSLASNATLVRRVLCRWLKTDRETVHASFAAQMKAARWDVYDRVACAAAVGDLEEVRQFFIQGGDLLRRAPNDTYLFVSPLIAAITADKTHIVDLFLTEIEANMVYQQALPHDYDKVVLPVWNQIRKALGAAMKAENIQPLLRLLAFVEPHFGDTESMQTIFLIAAEIGWVPGVIAVIDTIKRTVGLDSISILSGFSKAFQAGHSLAVRYMLTEDLVLITPDTTLSDTGKHPLHTAVRCHWPGIVDEFIRFGIDINSPDFSDHIYTGLWASGFRDSSMLDFLLNRGMDLNQAGATIIEDENYLTHLLAGDGLSANYIISTCTFKDMFPDTSLKCMWRSRTLAEIYESKVSHYRKEHPFTRAAEELVTWLSQANRNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBS5</accession>
    <name>A0A9P4PBS5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_364365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBS5"/>
    <dbReference type="OrthoDB" id="3548654at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="56"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="610" mass="68805" checksum="A03D72552DFF98B4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDI5</accession>
    <name>A0A9P4PDI5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_55096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDI5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="181" mass="20295" checksum="540845D9E30AB383" modified="2023-09-13" version="1">MYMCMYIAPHRIASHRIAPHQAKTASLVSHPSHTSHPRKPSMYDGHVKPRHALGSVWYGMVWYGATPQHPTPPQPAPSNPRLFPLSIPCVDTFLYHVFYSAKTSSYNTHSHITMLHNSQSVILSIGLCDTTSWFVSTIRKSYFTATNANCICPLCPDRIVVKKSRNLGIFAQDTDTEKGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEC8</accession>
    <name>A0A9P4PEC8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_67837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEC8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="141" mass="14869" checksum="2FF4435E144F7E5B" modified="2023-09-13" version="1">MCPPQQHAKHAPKTACYMPPSFKNTSAPLAPPPSKKSSHTTPPHPLAYPRAPTHRSRNKHRSDVRGSGLPARPNPCAGHAGVHTAGVGRRLGWVCVVGCVSEDGRGAANSRAEPAAAEGILRTRLCAMFSSNPTGREGEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEV7</accession>
    <name>A0A9P4PEV7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_446700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEV7"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="1">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="200" mass="22785" checksum="3EDCCA9D5E6DF689" modified="2023-09-13" version="1">MMKYIETPLSSEFIIRYKCSPGFRYASDHVYLEPSLDRKVVFIPDIRYSLKGGCESQICCGVEAWQGDVMQSHRFNFTELNIVEELMTDEMRRQMRDHGEIRLDFHFTEKGQTIAATDLPQLQFDDNGNSIAAKAVKETLAATGYMPTQPAGYSCPIREKIGGYLEEVKIVGKLGTFVFKYRTTGECFSKYQLQVTAQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF75</accession>
    <name>A0A9P4PF75_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-binding oxidoreductase ToxD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_391080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF75"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="10"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2443026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="368" mass="39293" checksum="D661407F7D92C6A8" modified="2023-09-13" version="1">MKAVIIKEHGIPALTDIKEQTMRPDYVKVKTVALGVNPTDLHHTAGAGRVGGIIGCDLSGIVEEVGGECKSDVKKGDHVYGVCHGANLTSEEDGAFAEYALVRDGHIAKIPEGLSFEETATLGVGITTIGQSLYMTMNLPLPGEKPIEGAPFFLVYGGSSATGTLAIQYAKLSGRTVVTTASPENFELVKSRGADAVFDYHDPECARLIKEYTRGELCYVLDCVSTESSYKLIAEALPETPQKPVQVVTLLPTDTWPRKDITATAILAYTSFGKAFSKFGIDFPEIAPHFEYGVMFWKLSQKLLAEGKVKPHPVALRKGGLAGIPGGIAEHAEGKVRAVKLVYKVDETDGGVSAPGSAIQGRELGSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFG3</accession>
    <name>A0A9P4PFG3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_56495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFG3"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="305" mass="34673" checksum="A4659238C393C763" modified="2023-09-13" version="1">MQNQSNAPFPFMQLPPELRDMVYENLLEDPHYPPPRPCPKTRGPSWLSSMAQLGSGSSTDTETTSHKSNFLFLASKQIYAEYMDLMCKKTTFHMTVAPHNYTPPAAPAEEEEDIWQISPQVLKKMKRCDIKLVTTSTMLGVSDPRNMKPEEWALARQMRRQLSEVENISELNLHVKAIGDPLWNPLWVWYHATEALREMGSSSDHGNEYVKVDVVDGELGSVASSGSGPSGPSGPQFNRITFSLDMWSPGENYLMRDRTNNNQWAWWCLKGHCVGQVGPELTVRQFCSWLYDCPTCYSEENDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGJ5</accession>
    <name>A0A9P4PGJ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate esterase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGJ5"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="228" mass="24681" checksum="8A7B74A3A25E6369" modified="2023-09-13" version="1">MYKLIEYLFEEIPNVTIILSTLLLNTNAGADERIRNIVNPQYEALVNSLQERQARIVLADLHPVVKAEELVNGTHPNDKGYEKLAEAWLGAIAEAGRKRLLVKPQNLGDPNINRPPKVGVHGNMGLFDSSKTFRDTHKATLSTVPTTHGNIPVAPTTSLGSTATPTKALPTPEVSCTRPVGQGPLEVGSQRPHCSILGKAPAYVSQILTSVVPQSNAARSNKPFWSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHS8</accession>
    <name>A0A9P4PHS8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_485344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHS8"/>
    <dbReference type="OrthoDB" id="4120917at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="110" mass="12815" checksum="5AB42631EE9C6749" modified="2023-09-13" version="1">MPEKSNRKSDQHSADWTTLKRLKREPTMTQDDWEKSITSQYDEWSKSTMAKNEMQVRALSYCVQEYQKNRDAGVDDLEVNAEGDEDNMEVDTEDNEDDLEVDTKDESDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHZ1</accession>
    <name>A0A9P4PHZ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_411198</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHZ1"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="590"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2445390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1010" mass="110408" checksum="04D27AEACBE5123A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJG3</accession>
    <name>A0A9P4PJG3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_485450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="889"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
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                <person name="Mondo S."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Barry K."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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                <person name="Liang C."/>
                <person name="Lipzen A."/>
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                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="Proteomes" id="UP000799764">
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="279" mass="31470" checksum="4E94A779E02916F5" modified="2023-09-13" version="1">MFRQRPPTNRSSTVIPSPKQYWSSVPNISAHRKHSIPSPDTPDTPASPLRQRSPTFKTAPTSTYYLRREIQELAERCNVLAKAAEDACYLFQNDVMALQGLLDRRFDAVDRAVATLDGRFGRLAGLAGRVTGADQSIGRIGDRPRATADRRRKQERLERIVFALLLFNLVLLVLLMKWTCSYTISRYFVVKYHSETVESRGPLPTHSIGSFVAFLRGPTNGRINPDMDMMSRRSDGDDGVRIAISGVSKHSICCALYIVCHEAYLIAKHVLTWRLCQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKJ4</accession>
    <name>A0A9P4PKJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatinase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_431141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKJ4"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000016">
        <property type="entry name" value="Putative curved dna-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="413" mass="45003" checksum="AF04336A7D79F6FA" modified="2023-09-13" version="1">MADETAVVDYTLANPDTLTKYKTAATIAEKVLKEVSGWIKADANIVELCERGDKLLEEETAKVYKGKKIAKGIGHCTTISPSSYVTPYTPLKSDAEEAATTLKEGEVVKIQLGAQIDGFPAIVCDSVLVGGSDEVSGREADLFLATHYANELLLRLMVPPSLVPTTGTEEEQKKAAARKPYTQSQITHLLEKVTSAYECNLVESTTIWLFEHNEIEAKKKIILAPGEGVKGEGLPDVGEVWGVEMGVSLGSGKVKSIDNNRTTLHRRTETRYALKRPTSRALLSEVTKKFGTFPFSLRQLEDEKSAKVGVIECVRGGVLRQYEVVADKNNEPVARLFSTIAVTKNGLARLAQPPAVDVSKYKTDKKITDEEVLKILEQPLGKASSNKNRKKKKKPAKKAAAAGGAEEEESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL06</accession>
    <name>A0A9P4PL06_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_384820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL06"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000173">
        <property type="entry name" value="Heat shock transcription factor Hsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="145"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="735"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="767" mass="83489" checksum="054F43AE581B5550" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PME6</accession>
    <name>A0A9P4PME6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_519086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PME6"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08994">
        <property type="entry name" value="GH43_62_32_68_117_130-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040388608" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="385" mass="42741" checksum="38CE9EE632D4C591" modified="2023-09-13" version="1">MHPHQCLLVALLSLLTTALACTTDDDCSLNGICKTNTAAAATCHCDAGWTGSDCGRLDLAPATRWTGYNHTNYTDSAYYGAYGNSSWGGRIIHDPDDPKLFHLLVDQFSHGCGLGGWRPTSFIARAESRNGPQGPYEWVQDVTTSFRHNADVLWSPAEAKYLLWAIGAAVEDPKSCKSIPGSRLPNNVSVSSAPSIRGPWTPFHVTINGTNPAPWPLYSPANKTAQIALAVEDFRIFTAPDSSGEFTRVNENVAWNTTDYSPTWTEDPFIWRDKRGNWHALAHWMIDIVEKNGTKYPRVGAHMFSRRLESGWTFKVQEAFSSTVAFTDGAVETFNRRERSKIFFDEEMTPLYLVSGVQAIGAKSSFTLVQPIGGRWKEYEKELGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMH6</accession>
    <name>A0A9P4PMH6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMH6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="186" mass="22083" checksum="176A6C283E7D54D6" modified="2023-09-13" version="1">MNSFLHVHEAEKALPYFIPKSKSDLTLPSLEKSNNEFPHHSTPSPHPTNSSPLKAKFASLLFHLADTLHRHTTQYPPPQPPHLPTLKWSWDPAWRELLVWAPQKQCYLYLGRYTHNEVGQLRHCNVSAREDWTEEKARRVVLSWEHWKIDAEGKWFLEVCEGEEKYWVCAAYWRAEKGKWWFVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMN6</accession>
    <name>A0A9P4PMN6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="4">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P171DRAFT_271540</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="4"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="484"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="19">
        <location>
            <begin position="743"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="247"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="320"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1078"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1181"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1253"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1402"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1114"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1184"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1455"/>
            <end position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2445709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1509" mass="166328" checksum="CA85E3BE9AC90691" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMR1</accession>
    <name>A0A9P4PMR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_239038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMR1"/>
    <dbReference type="OrthoDB" id="3889179at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="79" mass="9003" checksum="0FDC2FB5CBF38A30" modified="2023-09-13" version="1">MSEETSNGDYEYISYRTYNGVGFERLMSWKASKTGTGRVSAGKIEMKPQKSDVDKENEVLLVGHSVVVHKMEFKLVRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMR8</accession>
    <name>A0A9P4PMR8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_482880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMR8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="201" mass="22365" checksum="AEA0C0BF69931B38" modified="2023-09-13" version="1">MPPRPTRDEDEDEDEEKYEGRQYDEEGEGEEQEDSDEDGSAYEGEGDGEASDWDENAYDDNQTAQQGQGQGQWQEDDEEEEHYQAQAQEDDDDSDDEYEPQGDAQVNPHAAESQYLQEQHYAADMEHSSAPVSVGSSPGPEETGPGQGHLCDPCMFGSCSYGNQEAQSSSTPYLGHNGHRVVIPRDQVCECCQWDPNAPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN69</accession>
    <name>A0A9P4PN69_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_357511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN69"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="476" mass="51690" checksum="A731E711720D5E73" modified="2023-09-13" version="1">MVPDTPTEQPNTDTILVSWDSLSDPANPYNWSQARRWATTLLTSLGGLVTLMSGPMLAPALDVIGADLHISEAEASMALSIYVLAFAFGPMVLAPCSEVWGRKVVWVVGGSWYVLWNTLCGVSRSRGLLIMGRMMAGLGASAEFAVSGAIVADCFDSDDRGKSTAVRSFLPLLGPAIGPLVGGVMVQQVSWRWLFYTLSIFGAVLVILFALFLPETHAQTLLSRKAAKLRKETGKPFYAEKDVSSTTIAARLKITTLRPTIMLCTQPVIQLAAFLMGYQFGLLYIIHSTFASMWIDQYGQSHTASGLHYFAIVTGCLTALLIEWWAMDAIWARLKARDGGVARPENRVPLMIPGMLLLPIGLLMYGWAAEKRVHWAVVDVGAGIFGCGYILSTTAAQSYIIEAYLDYTASAAAASQLPRNIFAFGFPIFAPSLYNSLGYGFGNTTLAAIAIVFGIPAPFIVWRFGESLRRRGKAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP92</accession>
    <name>A0A9P4PP92_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_429473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP92"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="277" mass="31539" checksum="B3C74F4314A31E51" modified="2023-09-13" version="1">MADPEVPTPNVSKGASPPATAIATTSTSTAPSTSDSKAALATRMARFKALQSQKESGRRQTEAELRAAEDRPQRLAQLAKLQAANEKASYKLLKSDDPDFERKRNWDYTVEESESWDKRQAKKSRNRDNVSFADFRGEANKVYKRQVKQLGEKDMEEYAREKGERLQRQVRMGLLRLVEEGDEVFTVDSDGRINTPVEELYGHDHQPSKEAVDKLVEDLEKGERARLKARAARGIKDDGGDVTYINDKNKQFNEKLSRFYNRYTTEIRESFERGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPG3</accession>
    <name>A0A9P4PPG3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_382902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPG3"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057407">
        <property type="entry name" value="HEAT_TANGO6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23565">
        <property type="entry name" value="ARM_TANGO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TANGO6 HEAT repeat" evidence="5">
        <location>
            <begin position="250"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="684"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2447782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116562" checksum="201412A70DBDD301" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPS9</accession>
    <name>A0A9P4PPS9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_508290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPS9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="169" mass="18883" checksum="71653BB4C2600918" modified="2023-09-13" version="1" fragment="single">FTSGNKARTSPLVAVIIYIHISRSVCSVPFSDTAQSTEHAAGPKPRFRFSRVMEVHGRSSALHLHDRVGRDNDFHDSIGFTLSPLKVTIRNPQFDVELFTTPFCVVTSGYSDLFHGGPFHIRIFFESLRPKKFLLGRCVLGMLRHPHDRVEAEGKFGLEGCALRSVSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPW6</accession>
    <name>A0A9P4PPW6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_429558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPW6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="75" mass="8512" checksum="1F395E119166CF0C" modified="2023-09-13" version="1">MKRSEAIVRTGLESTIHPPLPHGTLTQQPNQSCRPANSYIRCLKHPRGHPGKWLSRLLLASVLLSDDQHIPWRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQG9</accession>
    <name>A0A9P4PQG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_440895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQG9"/>
    <dbReference type="OrthoDB" id="3750325at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="313" mass="33853" checksum="35AA37B1DEFC4725" modified="2023-09-13" version="1">MTSNGTSWSFPPALNATFVHDFYDQYALAHNGTEDDNGVISLLLAAVQNLTLEDRVDSEFQNEGWGGEDAVVTVGDTIDGGFKDAELRVHGLNCVLCKTGRGLGSVENACSNYTEGDNIQYYAKREGPAGLYLDLPELDQYSSLPNETCGLCIFSLPNEPGSLHFQDYSVPFLVQKQEASQRKVFNGSYPTGIVAPRSSSAAYPSPPSGASLGKLRQDDTSKNPNLIVGVVVGVLAAASIVMGLLIWLWTRRRGRKNPYDSAVDIRLATPQPRDGGPQSVPLQQVQPVVRRPDSAGDVPPAYHEVVRAKETEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQT6</accession>
    <name>A0A9P4PQT6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_430214</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CBP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQT6"/>
    <dbReference type="OrthoDB" id="5576752at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2447314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="117" mass="13432" checksum="45B298B96C178725" modified="2023-09-13" version="1">MPSPGTYMKAIGAGAALCIGGPALVWYVTPTEEEIFKKYNPDLQKRALAQRETRQQEFDDFVTHLKEAARSDKPIWTAQKEMDQKRSLEKTQRLRDEQASFTAEAERRRAEIRSSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR31</accession>
    <name>A0A9P4PR31_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PQ-loop-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_406727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR31"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2448637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="372" mass="41348" checksum="B813D9B94A95DBA2" modified="2023-09-13" version="1">MFPPSQGLRLDIDAISQICGSVSIACWIVVVFSPQIIENWKRGSAEGLSVVFITIWLLGDFFNIFGAVLQGVLPTMTILAVYYTLADIVLLGQYFWYEGFRLTDPVGSREESAEEDEEPTVPSEHSPLLSPSLRDRHDLPGNGFHTPPRISDADGRRRGSAHSAHSFRERFLSVSSTHLSPVTPLHDDTSPAPNKPPPRPHNPSALQAVLFNFGLIIIVCASGVFGWWLSTTRSNATSPPPTEPSPETLQFNLWGQVFGYICAALYLGSRIPQLLLNYRRKSTDGISMLFFLFACIGNLTYVLSIVAYKPVCSRPVHCRQGEVLSIYGRYIAVNLSWLLGSFGTLLLDAGVFIQYFLYRKEEDSDSEEEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRC6</accession>
    <name>A0A9P4PRC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_470455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRC6"/>
    <dbReference type="OrthoDB" id="3693043at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="346" mass="39522" checksum="572C9CBE59713A8C" modified="2023-09-13" version="1">MLSFAGCYPYRHLHCDLDTPWGTCPLWRHTAPPRLRNAIDLALQLVATKDGFSQVAQDAFEVLGVTVGSIEEFLHLSPKPWHIPTEADLHLYYSIYRPGYAFHQQHYDSEKHYYSAAALAIDFLGSHSPKTRCQMRELVLLEDCKGVGFPESHPAGLIPFFQENNRLRILRRLDLWRSEFPLDTFSPEVTPDFISMCMIPWIDEAYALAGAGMPSRCFKLQFHASNTHLQLIFDMLKRDAALHEAYQACCGKDGIQYAPDKLFIRYRNGRCFLSDVFPLAMRGIVQGSSTVQIDAEKGGIWDTAELAEVARGWTIEQWDDWKQRTTGPSITIDDYPVTHDELQSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRD4</accession>
    <name>A0A9P4PRD4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_428813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRD4"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="70" mass="7874" checksum="55BF4EFD612E17F7" modified="2023-09-13" version="1">MTSDPMLLEERFPDDWEPRIRSRFGLSLAAFNGTVLPVERGVDTKAYIRRLEGEGAEPTEPAKRVAGVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRL0</accession>
    <name>A0A9P4PRL0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RWD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_354359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRL0"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000075">
        <property type="entry name" value="RWD domain-containing protein (Gir2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="232" mass="26479" checksum="FF2D60AE26A3D53F" modified="2023-09-13" version="1">MGVEEQKEEREILDSIYPDEITDISDTEFRIAIQLEVSNDEGDDSEAQTATIILNVRFTPNYPDEAPDLDITQPPNAPKHPYLDIQDDKAVLLSSLTEPITDNLGMQMIFTLVTTLKDSAELLIIERQGAKAALAEIEAQKAEEEENKKFQGEAVTRESFLKWREEFQRELAEEEQKKKDEQEAEDKKKGRKEEKKLTGRELWERGLVGKIEEDDGEDALEQIKDLKIEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRQ6</accession>
    <name>A0A9P4PRQ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_236823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRQ6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="105" mass="11660" checksum="4EB0FE88E83C78DF" modified="2023-09-13" version="1">MSGNPNPTSRYHVRAYVCVCVATPPPPLQHPPTRLPQRRTTAPDPTPTHKLPRAPYKLSHATPPSHTSANSKAWPHTHAYVDIRTPSVRSSSIPKPLRFVSLRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRQ8</accession>
    <name>A0A9P4PRQ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_405847</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRQ8"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040124502" description="laccase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="91"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="217"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="425"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2450100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="582" mass="63181" checksum="14F4FFDF44829198" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS76</accession>
    <name>A0A9P4PS76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_236440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS76"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="149" mass="16528" checksum="DF03E09140F7C2BA" modified="2023-09-13" version="1">MEGGSEGVSETGRKEGSLVEGQSFLSRRQFGPRRRSHRQHQHQPTPREALRPGIAHAVPRPSTPSTAKPGATTLLEFHLLNRLPWPLHLFCCRNFSHLLGLLHVGRDALPLAARLADGRPTSTSDRMLRHRRMLQVAKTASASATTKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSB3</accession>
    <name>A0A9P4PSB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_189824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSB3"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="577" mass="62213" checksum="722AC0EB5B3F02CF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSB4</accession>
    <name>A0A9P4PSB4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_139631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSB4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="82" mass="9107" checksum="F84829B29DD68423" modified="2023-09-13" version="1">MIFRNPPCAVQSIHHLTIFVWSLSNSRKKTCRSSTRAPRPIPTLIQPPGFTPLFVSLLLTLRAYGARSDGLAVIVTLFSVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSJ6</accession>
    <name>A0A9P4PSJ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_503129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="388" mass="44752" checksum="839C77B11543EACD" modified="2023-09-13" version="1">METYQNSQGHSQDSRTAPISAETLRSVQRLQAEQNAQYVQHQQAQTPPSSVPGDPVDGHPNRGGSTRGAPRPQQDTQDAGMDRLAEINASLQMQLRQQQQHQEQQQQRMEQQIQRQQQEIQQLRMQRQPRPHQDMLNSRVVQYLEALDHHIDEYERNPTYDVKEKLGHFRQEIKVEILYHRDSHYSNWLRNSYERYDRIARQYNPQHQATQLSPPPSGMYADMRDSKVLQYLEVLDDYIDEYAGDPTFNVKEKLDLFKQEIKVEILYHRQPAYADRLRSSYERYNRIARQYNPQHQTRQLPPPPSGLMSGSSQQQLTGPSYQQPTGPAPRQFTGPAPQQFTGPAPQQFTGPATVATPAPAESSDTSGDQPPSRRMLVLPKGGIFDNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT70</accession>
    <name>A0A9P4PT70_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_148702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT70"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="491" mass="56187" checksum="8555BF39EA8F620E" modified="2023-09-13" version="1">MLHTTHCNHKGSFPMLTHYPELTLDKWARKYGSLYSVRLGNQLFAIVSSPGIAKDLMITQGAIFSNRKEMFIKSQIVFAGRGITATPYNDRWRKHRRIATTWLNQQAVDSYSNVLDFEATDMLHALYTDSQNGRHINPQTYAGRCSLNNMLTITFGFRTDSIHHPMVTEALRLSRAFMNCTGPMSNLVDFLPILQWLPSPLKSKAKALHRDLVETYGGLINEIDGRMKDGEQVPDCLAKTMLDIKDEENLDHVDMAILASAFMIGGVETTASIMQWFTALIPAYPDVQKRAQEELDRVVGRGRLPTLADEVKLPYCHAIIKEVERCHNPFWLGTPHTASSDFVYEGKLIPKDTVVVLNTWSMHHSEDRWERPLEFNPDRYFTDTTLSSTSANLADPYERDHWMFGAGRRICPGMLVAEREIWLAISRMLWAFDMVQIPEKPIDLKEYDGMSGRSPVPFDVRLEPRFEGVGEVLEREMREMRGWKGWGLTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT76</accession>
    <name>A0A9P4PT76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_480829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT76"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="326" mass="36092" checksum="86CC2F631CFEEAE0" modified="2023-09-13" version="1">MSDSSTSRVRRREALRIGAATPKAPVDGAAAIVASCRPGGDEEEMPGYWKVLIENVLDGMDERASWYYDTDSNSNYIIVKDVLGCFSIDYPFSINNDHNVDTRSAQAILRTVGTKHIMKMAAIPQSTLTFVIVHEPADSTNSAPINEVNVPGSSENATNARVPTQEDENAFRKQVYDDGADIMDNDTSIAKSAVFYDTLTKDNYSREYSSLLGLLHLHTPFVLRSLLARFRVVQGKVHGPQCSFLNCLQKFADDRTYGNSGQQADDNSEACSDKEFQAGSDNDSVKPPKSLRQVALRSTSRVQLRATFRIHLSLTSRVHLSYWVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT79</accession>
    <name>A0A9P4PT79_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_350954</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT79"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06621">
        <property type="entry name" value="PKc_Pek1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000294">
        <property type="entry name" value="Map kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="187"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2449757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="479" mass="51674" checksum="4A90378D46551A21" modified="2023-09-13" version="1">MSSPAPLLRPPIPGARSQGGARTPRLGLSIPPSPHARPVVNGATDGLTLRPAPPKLHLSTPMGTSQTPYEGRAQPRGLPPLQIGTGLSPAGGSSDASAHSRSGSFGEVPGNGSASSYNGALGFLHRGSDPISAISQGGSDSAPSMERENSSQPLPDLEKLAAEKGAPLDVDDLDDLGFKAASAKGLIEEKDNLGEGAGGAVTKCVLRGGTKVFALKIITTNPDPDVKKQIVRELNFNRECASDHICKYYGAFVDDSTGTISIAMEFCEGGSLDSVYREVKKLGGRTGEKVLGKVAEGVLNGLTYLHARRIIHRDIKPSNILLCRNGQVKLCDFGVSGEFGTKGDANTFIGTSYYMAPERITGQSYTITSDVWSLGVTLLEVAQHRFPFPADGTEINPRAGLIDLLTYIVRQPIPKLKDEPENGIRWSENFKYFIECCLEKEPPRRASPWRMLDHPWMLEMKTKKVNMGHFLKQVWDWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUA0</accession>
    <name>A0A9P4PUA0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_468039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUA0"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="48675" checksum="37D1D01335E1DC37" modified="2023-09-13" version="1">MAAMRDACPIPQEPYHPPMGPALLGGNATGQAQQSAGLFASSTATSQQPQTGGLFGGASAAQPSQPPQSAGLFGSLNKPQQPAAATGGLFGASTQQSQPQQGSSLFGGALGANTNAQNQTQTAQTGGLFGNLGQNLNQNQNQNQPKPSFGGSTAQQNTGSSLFGNAQQQQQQQQNQTSTPSLFGNNQQNQPQQSNTLFGGMASQNNTLGGLGQSSNLGGSQVIQMNDLSQIKGTTRLNDLHPDIQKQVFGLDDAIQAKIDTVNKMREAYPGHIQKLETIAPDVEYVEKKLATVALGLENDAASIAHLKTIVDHDANDAELSFRAIVNQALPAQFRYGNPSNLSASTTKPAAASSLENDDPTKPVDLIAYFNRRTDDLGKTLQTYQSQIREIEMHLKTMEAGAYEKTQQLAGARNKSMDDRQQLVEALRAIESAIVDSAKKVGKVRDDVTRHTLGGVGAPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUH8</accession>
    <name>A0A9P4PUH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_479595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUH8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="122" mass="12931" checksum="6120E9A4E71E6D31" modified="2023-09-13" version="1">MPARQATLTAAFGGPACLRIPPISKLGVDGFAQRALMTARSIKPVSRLAGTAQGRRLMAVILVLEEAWSPGRAANRTSEAPSHVNQRPPPAQTRSEGPNSQRTSRPVAVSHIEPADYRLGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUN2</accession>
    <name>A0A9P4PUN2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_145776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUN2"/>
    <dbReference type="OrthoDB" id="10453989at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="140" mass="16417" checksum="239C0BC65E1B8C37" modified="2023-09-13" version="1">MMSTPRCLWIFFLRDRWHQIVLHRRSGRMLVGVIVDALGYAGVWTSWSTPRIRCVSSIMNRILLYDDTTCTMFSDARRDGEVEEVAFRLVHRRLGRAIERIPAPLFLAVVTTSRYLTFCHVKPACTQMQIMPKMRLEDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUV2</accession>
    <name>A0A9P4PUV2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_378957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUV2"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="68"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="177" mass="19911" checksum="BF5F48A383CA2A71" modified="2023-09-13" version="1">MSFLINAFSQPSRAGNAWFCAGVVASYPDIEDDARLGEQRLCQGKYSPGCRIFHVPREDSSKAAEIAIDEWKDADAGNAKDQVMVFKYKGKFVAVNHECPHSSYPLSNGMPFDIEDFGITLSSGITCPKHEWSFDMHTGMSDRGSYKLQVWEVQIRLRAAESGAEEEVWIRRKQRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUZ9</accession>
    <name>A0A9P4PUZ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_450605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUZ9"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH10" evidence="8">
        <location>
            <begin position="50"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="325" mass="36147" checksum="067DDEED2EADE1B9" modified="2023-09-13" version="1">MNTITEEQQEEAMWGELANDSEDDEYTAEEKAARWQEMEDLGVDDFDEDYEPQLDCDDKFKAKGKLYFGTEIDHYNLINGLLTTIAKNSFYRATCEYSIEWDAIEPQCGQFSFSNADAVVNRATQHGNITRGHNQLPNWVIQTNDRATLTSVIQTHVTQMIATSSRVLVEDFAGIAFRVACAADPNAKLYINDYNFDIANYAKVTKGMVDHVNKWVSEGIPVDGIGSQSHLAQPSGWNLASGVPNALKMLTGANVKEIAITELDISGASANDYPTVMNGCLVVSKCVGITQRQPLLFDGNYQPKQTYNTLVNALRRILETGQSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV38</accession>
    <name>A0A9P4PV38_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_378150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV38"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13372" checksum="3326279A1593733C" modified="2023-09-13" version="1">MFFFFTCGTHTFTSSLKGAETLTFQCQNCGNHSARPMKRWEWFTFCFVPVIPFSLKPYKELGCHICNFWQDVKYRPDVQAQIGGAGGAPPQGQGYQMHGHEQGMSKPGPPPAGVPHQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW83</accession>
    <name>A0A9P4PW83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_204424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW83"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="101" mass="11387" checksum="DB7F2A2AB24BCB78" modified="2023-09-13" version="1">MRCAHTFQSQPHTHPVALPAQLSSAHQPYRLPHPHPSPRITQPQLPIHSPPAETNRNRTKRETRLRRIFCPADCTCRCRCTCRCTCACDPAGGLTARPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWA1</accession>
    <name>A0A9P4PWA1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_515413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2546325at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF9">
        <property type="entry name" value="NACHT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G01760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="373"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="2187" mass="246219" checksum="0F694FC987960389" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWA5</accession>
    <name>A0A9P4PWA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_450463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWA5"/>
    <dbReference type="OrthoDB" id="3788635at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="253" mass="27372" checksum="196005FCF786D4CD" modified="2023-09-13" version="1">MPDKPEARSRQEHIKIYDAPLRNIRIADSGNLLYGFEGIGETERVAVLDLTAYQKVFGKPQVLATRSRVLDSESGISQHIGELTRAGVLREALSQAQPGDSAMLAMTDSGAPALSILRRGSDDGSLVQKSLDPDGNMSMRTLMHLPEGLAKTADITMLRPQKQKAGLQNDSGHVRILLGVPPQDSYSFSSARNSSPKLPLPAVFERDASSITVVNIGTQPWIETSSHPHLLAENAESDKAATREVGVQIARKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX75</accession>
    <name>A0A9P4PX75_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_347466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX75"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040544950" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="32"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2451877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="570" mass="62764" checksum="FC3C0B00248535CD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXC1</accession>
    <name>A0A9P4PXC1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_516456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXC1"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2450614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="337" mass="37462" checksum="E1D96AC45B8061C0" modified="2023-09-13" version="1">MSAKDTSNFFTTEIERSQYWEDYLTARPDYAQSDFYASLLQYHCSHQGQSLPDPRQSVAHDVGTGPGQVAAVLSGHFDAIVASDLNESHLAIAQKRLARSLDSAALARVAFERLAAEDIHLTHEPASAAFVAVGEAMPLLDHAKALRSWATVLRPGGTLAIWFYGRPHFAAAEGYDAAACQRIYDKIADAMFAKHIKNGSGPAHKAGWKRATDCMSSFLDNVDLDPEQWADVQRWKWNSDCDMSFYGPDACDFDVEVVSCIRSEERVDVLGEPGFWGKSWTVDDWKLFLKMNLPAFRQEDVTPDIGRSWAELEKEMGGYGARHGVRWPVVAILATKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXL4</accession>
    <name>A0A9P4PXL4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_480123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXL4"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="10"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2451083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="347" mass="36806" checksum="777E8610B5928C55" modified="2023-09-13" version="1">MANQTKNLAAVLPAAQADFVVEERPIPTPGPNEVLVRNHFIGLNPLDWKRQLTGMFIPSYPAVLGTDLSGVVEAVGSNVSKFKPGDRVLGGADGIVSQKPENAAFQTYTILRSSSTSKLPSSVSLEQAATLTTSIVTSYLMLFHVLGLPKPELKAPPPNATVLVWGGASMTGNLTIQLAKLAGLNVYATASKKNHEHLRSLGASVLFDYNSSTVVEDAVAAAEREGKPIAYVADTIASTATLSSVQDILSKSTATAKVIAHTGPWPEDLPKLDAIDADMVHGEELWYKPDMIQLGSKIFHEDLPTWLESGVIAPPPYRVIEGGVGKIQAALEVLKAGVSNQKVLVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYJ4</accession>
    <name>A0A9P4PYJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zn(II)2Cys6 cluster transcripitional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_8471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYJ4"/>
    <dbReference type="OrthoDB" id="5319458at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="637"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="742"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2451563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="767" mass="85720" checksum="1A585C692030DEF2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYK1</accession>
    <name>A0A9P4PYK1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_478711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYK1"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35998" checksum="3EB80948BFF44B22" modified="2023-09-13" version="1">MGSVYNRALFTLAVADSEQHSEGTFRPRKTRCLRPFRIDRLKDVPYREREIFDGEEKFYIFPNTSHIHSGIRPKGPLDTRGWILQEQLLSPRILCYGNGEIFWDCLTVSVSESSPISTSLLNDDNPTEKWALKLLCRAISGSADTQILRQRLANVWKVFTQNYSARKLTLISDKIVAMKGILNAVEVIADETPISGMRRTDLWSQLLWYKDGLSKRHQIEEIHEVFPAPSWSWLGSEHPVAYQNTLKDSKAHELHDFTDLQPRVSIDDIQVANAPGQVGLHGKITLKGSCFRYRLTWDDLHRAPVWEALEPIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4F9</accession>
    <name>A0A9P4U4F9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_326696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4F9"/>
    <dbReference type="OrthoDB" id="15433at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15715" checksum="BDBF2DE378AE2B81" modified="2023-09-13" version="1" fragment="single">RFISKLLTWPERNYFYKRFPHCKVFAGEDPQALRKASYYLAGRWAAKEAVRKACEHLGDSNGFHSIMILPLSVFPKQPPGATSRPQALVLRDRLPELSPQHEDKVMNGGLDFDIDSLDGQLCEVSISHDSTYATAVALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4Z6</accession>
    <name>A0A9P4U4Z6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_477921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4Z6"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="63"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2437555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="696" mass="75529" checksum="890C985303CC91A6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5M2</accession>
    <name>A0A9P4U5M2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_174527</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5M2"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001164">
        <property type="entry name" value="C2H2 finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="296"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2437856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119645" checksum="6D665592F4F9363D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5V8</accession>
    <name>A0A9P4U5V8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase 14 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_398461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5V8"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="86" mass="10108" checksum="8EB68975D2032A24" modified="2023-09-13" version="1">MVHKVLFWGGFGVGVRLWQLGIEMRPLFNRESLWVYPVFAGIGGSFGYWLMGVEQRQWRVLADRRDALLEKRARRKEREEAAVQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U629</accession>
    <name>A0A9P4U629_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_369828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U629"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22762">
        <property type="entry name" value="OTU_fungi_OTU2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049771">
        <property type="entry name" value="OTU2-like_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="174"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="322" mass="36198" checksum="8DC924D4050F013E" modified="2023-09-13" version="1">MADAPEIPEAIEGLQVRHRKEQRDLVSRITQKKKQASKKTRKGVNDECERLEQELKERQARELAVFRGEDPDEAPALEEDEDTAAVEVVVVVGQVNGVAKAVENLTIGPAKNEEHTPERNGPGKKQNRAKARLARRAAEYDALVAQAKEEAANMPDLREQERTRMEQHFGKYGVVVKEIRADGHCLYAAVADQMETRGLGLKPRIQVKTQEEAKLPDYKRVRYAAADLIESSPDDFAGFMEEPLEVYLQKIRETGEWGGHVELMALAKSYGVEINILHSDGRVDKIEPGDDVKGQGAKEIWLGYYRHSHGLGEHYNSLRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6X1</accession>
    <name>A0A9P4U6X1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Pyruvate kinase</fullName>
            <ecNumber evidence="6 17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P171DRAFT_103701</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 17"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6X1"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="32"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="393"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2440584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="527" mass="57804" checksum="76EC1EC25BB04825" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7H1</accession>
    <name>A0A9P4U7H1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_476477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7H1"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040248544" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="15866" checksum="FD8FB02BD1994BF9" modified="2023-09-13" version="1">MQFLNSVFLISLLSTSLVSALAPRSSVNGPCTGAGGAPGVCISTSSCSNGGGSFISNACPGTAADVKCCVKTKCASGGSCKWTSQCGGTTQSGLCPGPSNFKCCTPTSGGGTLPGLNSVQTRNTRAIIARTKKDFAASQRKRACYVAITTAFQESSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7R6</accession>
    <name>A0A9P4U7R6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_418155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7R6"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="44"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2441529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="523" mass="57067" checksum="065A96D630C90E2E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U871</accession>
    <name>A0A9P4U871_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_433589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2441994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U871"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="115" mass="12953" checksum="EB6CFF04AC2BC517" modified="2023-09-13" version="1">MQTAALRHELGEEHSYEFVQGTMEWPMAPELEHISDATKPHFSYHNNTPESALEALGALDEYLASETPFDGILAFSQGAGLALIYARYFLHLHPERPLPFRCLLLFSPAIPLIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U878</accession>
    <name>A0A9P4U878_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable double zinc ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_446867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U878"/>
    <dbReference type="OrthoDB" id="3759180at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058253">
        <property type="entry name" value="Zn_ribbon_double"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26652">
        <property type="entry name" value="Zn_ribbon_double"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Probable double zinc ribbon" evidence="1">
        <location>
            <begin position="54"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="230" mass="26915" checksum="8B3B6939CAC6C265" modified="2023-09-13" version="1">MPYHDLSLARGLVAKHLQDLKTQTKSLFKRKDRPLDLPPSEPDYNTAPPSHWMGWWICSNCNEWAYPQHRLGPHPYGNLRCLNPDCKAVISPAAITSPALHRVTIVTPAQSFVPVACLAGAHREQIPYFTVCPCGLTHRARLYKQSLYRKWKHFPSSQQDESVIDKFRRFLKHKDKGDATLIEFEHVQCNKCYRKYDVHRWQHFAIYHDAVFHIDGRDEHGRWAEVRHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8F4</accession>
    <name>A0A9P4U8F4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_523862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8F4"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="7">
        <location>
            <begin position="120"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2440811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="455" mass="50271" checksum="E5EAFBEC9FC13C07" modified="2023-09-13" version="1">MAYTVIQTQTLRRLAPSVSRLHPRRRIASSPAAGNTAPTPAQPSSRPLARLSTPAVLRTLLLSRLFSSPALSRFGIAVLEKIANSRQPFLDPDKNLLLNRALRAGIYNHFCAGHESSDIKRTIADIKSVGFKGVILNYAREIIAHDLADADGLADVSAEHIQQWLDGNLKTLSAIGAGDYIGIKYTGAGGSVASALTAGKEPPKQFWDALNQLCRQAKAQGSYLLVDAEQQVYQATIDRWTVDLMREHNRDGDALILNTYQAYLKATRGVIRSHLELAQKEGWILGVKLVRGAYIFQEERDRIHDTKPDTDKSYNGIARDLLQRSFDDITKPNFPGLKLFLAGHNADSIRKASALHRKLSGQGTNPGTLEFGQLYGMADHISGDLLSMIEDHEKDSKEKHEAVQHVFKCVNWGTVRECINFLMRRANENAGAAERLQDGYAQAKRELKARIMGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8N8</accession>
    <name>A0A9P4U8N8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pantothenate transporter liz1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_434765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8N8"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="36"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2441081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="488" mass="54685" checksum="6146139467C6E964" modified="2023-09-13" version="1">MAPSFIKNFRSFIWDSDTHLKSHEERKLLRKLDFSILTIGCLGFFLKYLDQGNLSNAYISGMQEDLQMKGNEYTYAVTCYTVAYAIMQIPSNIIIQYIRPSYWLAAMEICWGTFTFAQAGVRSSNMLYAFRFLVGFFESSFFPALLFVLGSWYTKTELAKRIAIFHMTAPVGSSFGGFLQAAVYKSLDGHHGLAGWRWLYIVCGCMTVPVGFATFWILPDTPYTTKAWFLSEEEKELAIERVREAGKAAPAPLTVATFKGILTRWRWYAFVLGYVLYGSACGAGDYFGIWLKSEKFSVEDRNLIPTGSKLISGFCVVLWGFLSDYTGSRFALVLCPLIYGLIPNGILAFWPAGQGVKMFAFMTTGVQLMTAIFYSWANEVCADNNEERAIVISSMNGFQYAVAAWLPILIFPQTMAPTFRYGFPATWGLVIAALIAIVGIQVLHTREQRKKRLDESTVEQGSFDDSGEETGEVGSKSISGNIREAKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U921</accession>
    <name>A0A9P4U921_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_433313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U921"/>
    <dbReference type="OrthoDB" id="3946750at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1212"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1270" mass="140477" checksum="FF6126E3EA7731EE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA15</accession>
    <name>A0A9P4UA15_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of G protein signaling superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_365628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA15"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="85"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="391" mass="42787" checksum="61FDE2DB5C1391B0" modified="2023-09-13" version="1">MNSRKTVTQPLQIRTSPSSTASSPTTSTAEPDDEDVKMSMAEYHPPSRPLTVSIPRSIASASNRRPTLSDILANTAPPPYTLSSFMAFLSQNHCLENLEFTMDASRYRKHYSKMVNRHPGTPISPLSDECAYVLMLWRRLIDAYIRESGPREVNLPADVRDTLLHLSDSYVPPHPSALDEAVNKIYELMEESVLVSFLNSASPMSALASAVSHDSHESSTTRSSTRSYDERALYHPRTSAHPPVHQRASAPSSLTSNFMHARPFSHSRFNSQPATSSGSPSSRGPLSYASGSDALTDDSGSRSPSGMSDPLTPPGTPPMSDYPMTDFQQAYYENGSNSSTPSPRASRGEHSGLANATRDSWKRVSSKLWPKKRSGGHLREEEQGVVEGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAH1</accession>
    <name>A0A9P4UAH1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_487190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAH1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2443240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="579" mass="65382" checksum="C59B81C8E76D6CCC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBI3</accession>
    <name>A0A9P4UBI3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_463058</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBI3"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="385"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2445624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="452" mass="50182" checksum="59EEA8A624DFCC5B" modified="2023-09-13" version="1">MADSVVAIQDEIALLEKNLAELQDQLKDAKSRLQKAQSEEVAQSGQQVMSKEDRLALIKVNLKEVLNPEIMDAVLDKGESLKVYWGTATTGRPHCGYFVPILKIAQFLRAGCHVKILLADIHGFLDNLKAPIELVKFRAEYYRYVITALLKAVNVPINKLQFVLGSSYELAPDYMMDLLRLASITSEHDSKRAGAEVVKQTENAPLSGLIYPLMQALDEQYLDVDVQFGGVDQRKIFALAKDVLPKIGYKERAHLMNPMVPGLQGGKMSASDPDSKIDVLDTPDAVRKKLKKAFAPPKEVEENGVLSFVEYVLLPAGELRHGTPKFVVERREGEPLVYTDIEKMQEDYKNDILTPQMLKPAVTEALIQLLAPVQEAFQADSKWKDIEQKAYPPPPAEKKKEKKKKDKGTGYPGAKKVETKPDGHVEGVDKATVDVGADGGAQAIEQLKLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBU6</accession>
    <name>A0A9P4UBU6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WLM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_432567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBU6"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07344">
        <property type="entry name" value="M48_yhfN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053136">
        <property type="entry name" value="UTP_pyrophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30399">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YGJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30399:SF1">
        <property type="entry name" value="UTP PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="10"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="460" mass="50849" checksum="4C7200A442CFF1EC" modified="2023-09-13" version="1">MPLGFERINERTQRPNAHINFIRPLPGPSAKTAEEILSRVAAVCYPFMKSNMILVQALEEFPFNREFVGRNFNAGEVVQLVLRDRNGMWLPQRMVEMVMVHELAHCKQMNHSPAFWKVRNAYADDLRALWVKGYTGEGIWGRGRNLDTGALQQEDRDPGDMPEHVCGGTYGRRSSKKRRRGGETKQVFTYAERKQRRILKKFGAGGQSLGSDEDTKVKLEGGVTKKGKPRVAGSARGRELRAAAALARFDTAKQEQVDVKEEVPSDSETEDDEIEFVEGSAAIDVDGKEMTDDKGRALVKICEDEDTRDGDAQREMDELHVLTRPDPNPKKPANSSRTRKMPSPSSAGSAEPIKPVSIKSNSVSRHPTNAKSSAQVIHMDEIHKRRLARSPEPRPPPATITCAVCSLENEVGSLTCVACAHVLNPRMDSNHWSCKSAACKGNSYINAGDVGRCGVCGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC28</accession>
    <name>A0A9P4UC28_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_412638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC28"/>
    <dbReference type="OrthoDB" id="5367584at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024312">
        <property type="entry name" value="TACC_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12709">
        <property type="entry name" value="Fungal_TACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="813" mass="89645" checksum="22E680F5DD1AD5C9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCB8</accession>
    <name>A0A9P4UCB8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_387745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCB8"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="305" mass="33783" checksum="2DEEE9CE4834794C" modified="2023-09-13" version="1">MAPLVKVAVIQLYPKPMQPEHNFNKAATYIRSAAAQGAELAVLPEYHLTNWLPKDPAFVGLCDQWETYLNKYKELAKECGICIQPGTIVESHPQEEAEENKLLNVAYFIDHEGNVVGKYVKKNLWHPEREHLTGSGRDIHQVFDTPIGKVGMLICWDLAFPEAFRELIANGAKIIITPTFWTLNDCNPAGLALNPSSEALFLDSMLTCRAFENTCAVVFANAGGPPGSGYAGLSQVVVPFIGPLVRMGSCAEGMSVADIDMQVLEDAEANYQVRADLARDDWHYDYRHSNSDTKDDEDAQVKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCV1</accession>
    <name>A0A9P4UCV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_462360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2447124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1401" mass="151737" checksum="ECD6B58EA2A44ED1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDY1</accession>
    <name>A0A9P4UDY1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_428409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDY1"/>
    <dbReference type="OrthoDB" id="4847120at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="162" mass="18257" checksum="F86A50D7033D898E" modified="2023-09-13" version="1">MRILQSSQNRTRAAVTPKQRCGNSLLRDSRFCRDHACLIRECPRERNEDGGLYCRYDTCRSDLCFNPVATLGSSRYCTDHECLATGCYQEASPAGVLCKEHTCLAKSCLRVCVPGLFGYCKRHEHKGLRSNDNFADAATWTGHGCSEGHNVHEFGYNELEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFA4</accession>
    <name>A0A9P4UFA4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1593-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_507490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFA4"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040201824" evidence="1">
        <location>
            <begin position="25"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="2">
        <location>
            <begin position="30"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="3">
        <location>
            <begin position="424"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="505" mass="56117" checksum="D0D5CA35EC61DD47" modified="2023-09-13" version="1">MIFSIPRLLTIGLLASVIPAHSIGRMERFRTVVTTDMEQDDLASLVRYILYTNELDTEGIIYTSSKYHWAGDGKGTKFFLPNREYNTSQTSWRWTGTRMIEDILLKAYAEIYPNLRVHDSAYPTAKDLLSKVKIGNIVFEGEMDKDTDGSNLIKSLLLDDDRRTLYLQAWGGTNTIARALKSISDQYSHTKQWRQLQTSISRKAVILASSFQDQTYVDYIAPNWPGLRVEDFATAYNTWGFNCNKGQGNVRALPKAHEYFTGAWIKANIQIGPLGRLYRSWLDGQHTPGDQLDVFGNYTLASAPGTWCKPLGPYDFLSEGDNVAFNPLLTTGLQDPSNPALGGWGGRSKLNSSAPELWRLVASETAANGSEVRGWTTDRWIAAASNEFAARMQWGLKSRYSGGNHAPEVRIVNGGKVKARAGQTVKLAARVSDPDRDAVTVSWWQYLEEGTYPGEVAVGGYNRNGASVKVPADARSGQTISVIVQATDDGEFPLTRYDRVIITVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFM4</accession>
    <name>A0A9P4UFM4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isy1-like splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_406820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFM4"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="253" mass="28948" checksum="B408BE530BE8C86F" modified="2023-09-13" version="1">MARNSEKAHSMLFRFRAAQAAEAGIIDISRTRRPKLITGVTGIPVCEKWRGQVLKEISRKVTKIQDAALSDYQIRDLNDEINKLMREKHMWESQIRNLGGPNYMRGGRVLDEEGREVPGGGKGYRYFGRAKELPGVKELFERQARPEDDEGAAKNKEKRSELRQRVDAGYYGYNLDEEDGTLLAYERAKEQEAWDDFLALGDDLGVKPSRTPRPFEDLPGDAGDGVRWNVPTLEEVNEELIERRKRKLLEKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFR4</accession>
    <name>A0A9P4UFR4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_231788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFR4"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="60"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="233"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="330" mass="37281" checksum="82ED19AA8830C765" modified="2023-09-13" version="1">MSARQDIGDPVAPVASNGGEPEAQNSGGDADDHGPGNKRKEAPTTEGAPSKKQQKVLENRAVYATNIPRDATFEEIEDTFKKAGIIEMGVDGKPRIKMYADEHGDFNGDVLVVYFKKESIQQAVMRIDGWEFRPGQTSEGVVKVQEADMSYKKETDGEVVKSKLVRKDRKAAERTRAELNRKLAEWSDDDEEDIQKTFAPKKNQWAKFVIIKKAFTLDQINDEEDEGAMLEIKEDMRTAAEQFGEVTKVVLYDKEPEGILTVRFKEFEEAEAFVNAFNGKGYNSEKLELSVADDRPRFKKTNRDDVSDVEDNVRRMEAYMDGDKTDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGC6</accession>
    <name>A0A9P4UGC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_353249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGC6"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="479" mass="51777" checksum="CFA78FD5C927F47C" modified="2023-09-13" version="1" fragment="single">PQCTALDNFLPGKVVFPLSLSYASSQITFWSAQEQRLRPSCIVIPKSTQDVSTAVTILNVGYQAAIPGCKFAVRGAGHTPHAGAANIDGGVTIDTQSLNQVTVSSDQKTVSVGPGNRWGNVYKTLDDLNVAMVGGRLSQVGVAGLVTGGGVSFFSGRYGFACNNIKAYEVVLGNGTTVTATSTRNPRLFRALRGGSNNFGIVTRFDATLFQQDAFLGGQIDQPVTNKEAYFAFMANFTQSKNYDPFSALITVFAWFQGIPVSIMHTATYTNGSATWPPPVFAPLDAMPKLSKSVRKAKLSSFANEIGTDASVSQSQNNFFLTLSFVNDPAVSPGYMAQVYKLVDKAAQDLFLALGLALTMAFQPMPHVMYSKGADQNVLGLGRFKDDLINLLFTVIWPSPLDSQRVYDRMKTLENDLIALAKAKGIFNEWVYLNYASQWQDPITAYGASEVAFLKSVSKQYDPQGIFQKAVPGGFKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGI9</accession>
    <name>A0A9P4UGI9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_350158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGI9"/>
    <dbReference type="OrthoDB" id="5274873at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18418" checksum="4D3A8947E65DEE79" modified="2023-09-13" version="1">MFYIMYLTGLCQRRHWPDPLFQTYRTRLGYGCTVRVNNREYSTDVEYETDELAKNAAATRAYMICRNFSVNDGMYPGQRPGQGGVVQGLPVAIGTGRRGTVSSAEFDSASSSGGNSPRNSDYGLEDSAGRRSSKSSTSSISSCMCGRGTVRAYERCTYCLREAGYHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGN7</accession>
    <name>A0A9P4UGN7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major royal jelly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_439904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGN7"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040215128" description="Major royal jelly protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2449375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="46990" checksum="C0CB8F5AF53F2AD9" modified="2023-09-13" version="1">MAAKVLIALLSASLTASQVTFQNSTGTRLRVDNGTYGPPIEETNIHLDYDQWPIGIAVASDGRIFTTYTRGSYKYTLGLVVNETAEEPYPSADLNLPPDQLNTTWNGIPFGSSNASAFISVQAIYITPATSSRPETLWAIDTGRPTVHNAQGDPSMPYAQPGGPKLVAISLSNNSIYQTYTFPADVHYPDSYLNDLRFDFNPNLSDTSGAGIAYLVDSSNEGRPGFIMVDLGAGTTWRRLTQDASVLRGATDIPSYQGQPFYLRQSGMPITTGQQEGLDGLQLSLDGSRLYYSPLSQRTLYSIPTANLRTPPSDPRAEVHAHANVSSHGGRGGDANGFEGDSNGFVYQLMPEHNAIYYFDPADGLTHGFVRDPRIIWPDGASVAADGYVYVNVNQLPYQPDWNDGVDGRTYPGAVLRCKLPGNGTKVASLYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIB0</accession>
    <name>A0A9P4UIB0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIB0"/>
    <dbReference type="OrthoDB" id="4187949at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="557" mass="63803" checksum="E8F272F0844EBD00" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIH5</accession>
    <name>A0A9P4UIH5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GCN5-related N-acetyltransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_479405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIH5"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2450307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="172" mass="19066" checksum="F41EA16170BB3871" modified="2023-09-13" version="1">MASDGATIRHATPEDVDTIYNLIIELAEYEKAKSSVKATPEVLAKTLAFHDPSTPNSFTPGYARTFLLVAPEGEIAGMALYFYNYSTWTGVPGIYLEDLFVKPKYRKQGYGKALIKACAKEVVRINGQRLEWSCLDWNTSSLEFYESLGATQKKEWVGLRAEGEALAKLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIP5</accession>
    <name>A0A9P4UIP5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_479603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIP5"/>
    <dbReference type="OrthoDB" id="5360229at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="121"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="231" mass="25931" checksum="E4A1F39CBD6F9509" modified="2023-09-13" version="1">MDSRSSASLEDFLRTSQSTTDAISAASLEELSGTCHPTIDAISRANIKELLAMVAALGIDMSAPIPDDMPASVEDFRVWQQDLFDEFAATQPQQCKDNITVLDPIPVMSTPDDEHDPDYSCCICSEPLLSDQSPTPTVVKMHGCRPAYHLDCLCTWWESSGTNTCPHCRAVIPEVKLARQWDALDDPWEDWGEGEWTEPEHGDEFWWPFFYPYGEDLELVEDDGELVEDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIT9</accession>
    <name>A0A9P4UIT9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_480032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIT9"/>
    <dbReference type="OrthoDB" id="3798108at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1013" mass="110522" checksum="24BC52B1127631BA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ03</accession>
    <name>A0A9P4UJ03_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="10">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_147280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="10"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ03"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040158446" description="AA9 family lytic polysaccharide monooxygenase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="362"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2450832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="398" mass="39904" checksum="0583C1216C5C468B" modified="2023-09-13" version="1">MFSKTILVSSLIAAVSAHQNFHQFWVNDETPGYQVGIRMPPSNSPVTDVKSEDIACNVNGQTGVADTVAASEGDSIKVQWDQSGHPGPITHMLFGPVDSAKAATGVGSWFKIDELDNVDGKWANEIMGANNMTHEFKLPTGLPSGEYLLRSEMLALHGAQTVGGAQFYVGCAQLKITGTGSDGACGPTIELPGAYNEEDPNIYIPNVYNGFDATNYTAPGGPVGSCGGSGSTTPSPSKPASNSTTPATSAAVASSVVATTASLASSVAVSSVAAISSAPVVSAPVASVTAVSGGNNTASAPVASVTAAPGGNNTASALPSLVFPSTLQTSVIAAPSTFQTSVIAAPTNGTAPSAPGSTGTVGTVKKYGQCGGKTYVGATSCVTGSTCTVMNDYYSQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJQ9</accession>
    <name>A0A9P4UJQ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJQ9"/>
    <dbReference type="OrthoDB" id="3508922at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040433468" evidence="1">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="163" mass="17993" checksum="C1713844225B0042" modified="2023-09-13" version="1">MVSFTTLLALSATALASPVLQSRQIAIPENWSWHVSGWTAGCAKQGCFYNFNVTVPTVEGQIAGVKAYCNGYETGYYRKGNWYESCQILEGVNNGVAAKFSERPAKSETESESPQEIFLSFEYAGFEDRPAYNFTGSHKVIYNQFTAPVQEFDVKPTEVSAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJR4</accession>
    <name>A0A9P4UJR4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AFG1-like ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_346240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJR4"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28571" checksum="8324F97F9D2FFDAA" modified="2023-09-13" version="1" fragment="single">MAQHQTALEAAYRALISRGRLSHDHGQAALVTRLAQLQTSLTQLGSTSTNAPAPRGVYIYGSVGTGKSRVADLFAATLPSQISRRRIHFHEFMLDVHARLHAARSQPSFRGDPLIQIGMDVRKESQVLCFDEFQITDIADAMILKRLFAGIWGTGGVLVSTSNRPPEKLYENGLNREQFVPFIHELRRRSEVWKMEGEQDYRTKDIDDPVDRIEVFFLDPSKFEESLHRQLSGQELQRFEIVVLGNRVVSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJS7</accession>
    <name>A0A9P4UJS7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_16315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJS7"/>
    <dbReference type="OrthoDB" id="10531459at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2452003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="120" mass="13672" checksum="3EBE0291BAD33162" modified="2023-09-13" version="1">MQRCLSRSLEITVLGRGSCESHRLESVIKPCEERLCGQTRLCEARQSWITCTRQIRLLTLYSRERVSESKVTVANSSCMSILFLAMYGRLAQKAEAKNGDLVVHARWPVSLQLETRKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P344</accession>
    <name>A0A9P4P344_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_182711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P344"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040258889" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11888" checksum="53033F930AACA5BB" modified="2023-09-13" version="1">MNTFCLSWVRPVFHVLFLGALGASAQDSPEYIIRWISEGGCPGYEECIRRPLALMLMGCIVCKNHDSKIFTSRSFCAACCFDVVLMALRDSLRRSWKHVTPRDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4V4</accession>
    <name>A0A9P4P4V4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_506311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4V4"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12099" checksum="9F98ED375E2D3D12" modified="2023-09-13" version="1">MESSPVTDHLADFKMKTLADIAADTFKGNPTTPKVTEDRGTTEGQPSTLHTPLQEGEFRLLAISPSDDLNAPLVCTLRAVTLSQARYTAISYVWGDPSNPEEARINGLSVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P569</accession>
    <name>A0A9P4P569_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1264-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_437033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P569"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="233" mass="26791" checksum="2003CC9D0B9E1A8D" modified="2023-09-13" version="1">MDSLPVTNNTTGEPESLKNKVLETGAAAAQNFEPVQRICAHLNAFHAYADDPHRAPVEANHYCAHLNDEVRQCILYDSPKQPARIIGIEYMITPRLYNTLDQAERKLWHSHVFEVKSGMLIMPKPSVVPDAAWELAENREMEEVVQLYGKVYHLWQTDRGDTLPLGEPKLMTSYTEAQQIPGGFEKVIGERDERFGSDWRRKKEVRSYIEEPQIHEHADWAWKGKKAEERGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5V5</accession>
    <name>A0A9P4P5V5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_176205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5V5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="117" mass="13687" checksum="CE285AC1B597F6E8" modified="2023-09-13" version="1">MYSMQPPIRRGYILEQTNKENPHKHKKQIAPPPQHTYISISLPKCQKKKTEKSQLQLQYMYPNPLALTANHARRLRGPWSWPTQPARTPDAAINRNLTEKKKKKVVSFFALGQNRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5Y7</accession>
    <name>A0A9P4P5Y7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_505645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5Y7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="215" mass="22441" checksum="1BAA3D53941A4774" modified="2023-09-13" version="1">MAWDMVRSGVARAAADADADADADADARRQAKCPSPPPTAHRPPHRPPPAARRPPPAAHTSPSPRRPLDVASRLAALSSLARPPPPPALLSSSHLISSHAQLAPPACCKGDPSLGATASPNMNYEHANLRSAPGMPMPAPTAGRQNTPRRALDAPCPAPCSSPLSRRSSLNHRCYSAARLDESWAACANMACERKAEPSGSNQALVTARHCAGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P643</accession>
    <name>A0A9P4P643_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_526794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P643"/>
    <dbReference type="OrthoDB" id="3792934at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="422" mass="45952" checksum="86C4E1AE3A9546BE" modified="2023-09-13" version="1">MARAGATPPQPSGKQPSINMQQYRDHLTAQQATQPDMHAHKKPRLEPTQDASREPQAASRAAHSSSSQTPAIAHVSSSHASSSRPAPHPPSSQLTRVPPLRYPSAIAAQIAHQWQPCWLPSSGNRGVPLTSDDSIPHVTRLVAAFLDTTLVFDSLEAAAQFAPGGTWTEHPSDIELVCWNLVQACVSLHTVGAVELKMRRMPEMRPEAGSADSKMSFAGRVYFLELMARHFKVFAHGVMMGSGGMEELVMRIHTNLFQKSRFKEVMVKKMTQEQRWKVTEEFQRREAEGNALAENYEADGWSAEPIQPVPEEANHLPRQQAGAKTATAPAPSIAPSPGTVHAAGKSVQTMQPPLAGASHPQRQQASSKATPAPSPRPLRTLAPTPRPPPPPTAQRRSIPIIEVSDDLVDGFPWDEWVDPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P657</accession>
    <name>A0A9P4P657_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase family 93 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_398926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P657"/>
    <dbReference type="OrthoDB" id="2130735at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="229" mass="24619" checksum="3D9B218C8FD17212" modified="2023-09-13" version="1" fragment="single">ADETGTTLLAVNAVDDRTTTIELYTSGNQGENWDLASEIANGGPLNNATAAVANPFLVHNGDSITVFYAGKGDKTHAQKIVQQTTTENYDSWDNPVDVVTSQFLSDQPAAPSIAKVANNKYIIAFQCGLRGADTNTTTYPIYYKITSNPQKAASDRTREVRVDTGLVPSGVPSVTWTPLGGPNGTIVLSDSKSNSVFVNQNLGEGEWWELNTTAGRAFGREVTVRKWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6Q3</accession>
    <name>A0A9P4P6Q3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_449780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6Q3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="516" mass="56502" checksum="B33E38732CF4DCAB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6U7</accession>
    <name>A0A9P4P6U7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_449832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6U7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="218" mass="23779" checksum="F46F7790A2FCCE4E" modified="2023-09-13" version="1">MEQYRDTSFARIDDLATSTGGNAIPFSAILGAWEDAACEYEASIAFEQLRTVDAKKVVFEHAIANVRVSKYIQRLTKSAWALSVDNLAEAFGYASLMEPSFARNLVRLARRAGHTPWATVLAAIQTARDARRSSVNSRDQPTGAKWLAEDVAVAADALELPIDRRGPTKRQPKSSTKVSPSHQARKAANIPHRVPSHASSPGSTTNLRKRVVLGEISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P741</accession>
    <name>A0A9P4P741_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_176347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P741"/>
    <dbReference type="OrthoDB" id="5278208at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2437928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="754" mass="84806" checksum="735856BC9EF06C26" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P753</accession>
    <name>A0A9P4P753_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_437711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P753"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="97" mass="11402" checksum="102C0FF645E6604B" modified="2023-09-13" version="1" fragment="single">MIGLVCLSVLAFLALPATGWMRARRHKLLLALLVLVILAYQRYGFRMYVAYRDYYHEPMPCSEDTICHKYPARTEEEKQKWEQVLQPPSPTTEKPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P797</accession>
    <name>A0A9P4P797_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_466226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P797"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2439705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="247" mass="26993" checksum="F14A07A74A3758D4" modified="2023-09-13" version="1">MPLDTSTYSLALLRLDGRRWNELRNIHAQISTQAAADGSSYLEMGNTKVLCTVTGPAEGRQSGQRGGRDNEAKVEVEIGFAGFSGLERRKRKNDKRTSEMQHTLETAYSSLLLTHLYPHSTITLNIHILSQDGSLLAACINAATLALIDAGVPMTDYLVACTAASSATSAESDNSDPLLDLNNLEEQELPFLTVGTLGRSDRVSVLIMETRVRMERVEGMLAVGIDGCKRMREILDGVVKEYGKRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7F7</accession>
    <name>A0A9P4P7F7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_156588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7F7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="213" mass="23439" checksum="DA0B595F3178607A" modified="2023-09-13" version="1">MTQGCHPGSHNGKGKPTEDEDASGFERSVQSGFYCAFATAPSYQAMIPYSRFFYNQDSQSANALCLGNRQCRDGGLTFHYTCQPSSSTTVTKRRSVKLPTMRGDFTQTLCAVACNHTGGRKLAPFAACERNETMWARMYNARMRPGTNNDPGLSRFTLISPYLRAAVPANKAAVARPFRRTAPLGAQTCVSKISKFDSHTMTLLIPRWAGMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7L9</accession>
    <name>A0A9P4P7L9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_449396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7L9"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2438183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="323" mass="35878" checksum="D53D212F1E29C944" modified="2023-09-13" version="1">MSDRPEHAEDCTAVGPGCPVEATLYGYYPHIVWNAFFVGFFGLCCIINLVLGFSYRTWTYMIALCLGCVAEAAGYYGRVMMHKNPYDDIGFQIQICLLIISPAFVSAGIYLTLKHFTLTFGASWSRLRPARYTYIFITGDIISLVLQGAGGGLAATADNGSSTQDLGTNLMIAGVVFQVFILSVFGYLLAEYTLRTYRRREKLSVAATEILRSTKFRLFGAAVMVAYLSILTRCVYRIPELTGGWGNELMRNEPEFIALEGVMITLAVFMLTLFHPGFCFPVLGAKQAAKYATVNSKEHYAESSVEMLPQRDTAYEPYSHRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7M9</accession>
    <name>A0A9P4P7M9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_371110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7M9"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="319" mass="36257" checksum="6E3075D51DDA85BB" modified="2023-09-13" version="1">MASTIVGKSGRVYVQDKVLQRHREDHNLSVFKAESENESFVFKRVPRSFFDLSLRLAAEFAGSRRLRMHIDCNQEENILIYPFFSDTLLALIQGDPDFPVAERKKILRHTGEAIQELHGKDWIHIDVKPDNILVNWTCDKEGNKTVNDVVLGDFDIAFKLEGGEPRQTPYAIGNVMWRSPEGQTGKGVTKASDMFSFGLVCIYALGGGEFLLLNDYQELAKRGIRPEQEILVRHFSYFGPVPEGLLKQVNSEDWCNAMKGASEMAVEAVKEQPELRFERWGEELGPEAHNMISGMTNPDPTARTPIHQVLAHRWWQEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7X4</accession>
    <name>A0A9P4P7X4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_334645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7X4"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="229" mass="25430" checksum="83768DE7BD427FA4" modified="2023-09-13" version="1" fragment="single">PPLAYLTTVICFDTEGWNADSSKLTEVGFNRFFAESVRQIEPGLWGEGILRKASFYHARIAENSHLQTRSGTKGDPTSNRFGRTRFLSSKEACIALEEFFAVRTADGQGICPVVILGHALGGDIEKLWRLLGFDPNRLGNVVKEIDTQQIVRDMGFWIARDQVGLQRIIFTLGFEYRDAHTASNDAAMTLIAAVLLVLPGNGSSEEKKLQEVVDEIERLSQGDTWDHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8D9</accession>
    <name>A0A9P4P8D9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Radical SAM enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_491043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8D9"/>
    <dbReference type="OrthoDB" id="549750at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038283">
        <property type="entry name" value="viperin_w_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01088">
        <property type="entry name" value="antiviral_proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00318">
        <property type="entry name" value="Viperin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="39"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2438371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="342" mass="38935" checksum="E3B0404C481B1CAD" modified="2023-09-13" version="1">MVFLGILTNAAIIPIFIVLVAAYILYGYVATGQQSKPKNDPNAPVSVNYFPSRKCNYTCGFCFHTDTSSFVLSIDEAKHGLRLLKEAGMRKLNIAGGEPFLYPLFLAMLLRYCKEDLGVESVSIVSNGSKIREKWMKQHGQYLDILAISCDSFNPETNKKIGRGDDGLNVVRLFQIAEWCKKYGVKFKLNTVVNAHNWDENMVSEIEKLAPFRWKVFQCLIVAGENDDETRKRDARDFLVTDEQWRTFCDRHKHLPCYVPEDNNSMASSYLLLDEYMCFLDKGEGMMTKSESILNVGVKKAMEQIVWDKKSFADRGGIYDWTRLDQTQQGSCGGGGKKELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8U8</accession>
    <name>A0A9P4P8U8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLAC8-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_396704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8U8"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="146" mass="16490" checksum="731518E950AB0806" modified="2023-09-13" version="1">MTTIQKQDWHHSGSGCCSPMGTCCLSWWCPCMQYGKTRHRSKNDGNMQGYSCCNSSCMAFCGLACLGISFILPMMNRSDIRAKYHLKGNGCGDCLCACCCTPCDLTQQEKEVSYREESKHLLQPQPGKNEGMYYAQQPQQQPHYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9N5</accession>
    <name>A0A9P4P9N5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_133595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9N5"/>
    <dbReference type="OrthoDB" id="3776601at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="49975" checksum="B9EB58725BB3B027" modified="2023-09-13" version="1">MSRAPLHGNGEPPLSLPYAQPPATPDVPSLVPDIDASINTVSPAPPPQSSLSAHNTEPEFRRPTAPSSIASHRRKRANDDDAVSRTSSPAKKSKVSESTFTNSYKEQLQTYYGGCCACEVRYYLHAAHVIDKAVGPDLSKLQRQGLVSLRTLGDFENAIYLCPADHAAFDARDPGLIIVPTYFDFFIDHERRWQQEMQKTTPPRVRIPVLPNQYAAYCAEISGEEETKGRYTAYMVVDYKEEGRIGPPRMLEWHGDPGAILWKARCLAVLQLGSLEPEPAHLLQLIAVKKQLRYLTDLQEAGDLEWKSRSNACAARDHPAGGGPPPAGPSNYGGNSDQGDRTRDNQLPQPPSSGSPGAAGLHPYNPPFWNTLSLQKDTGVYPQICGTKRKQADLGFSDDSERAKPIGRTGASLPRPPESRRQAYRWGGSTSSTEENVRYWNAVFGDTSRTRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBI6</accession>
    <name>A0A9P4PBI6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBI6"/>
    <dbReference type="OrthoDB" id="5073671at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="260" mass="28377" checksum="84BB9918543B941F" modified="2023-09-13" version="1">MGVPEKTAPLHSVDAAQPAPPAYDQNQPPPAYVHSESSTTRQPHNDSQHSGSSPQPQHMRFPSQFNVYTQFSTFTIGPHQDEKLFTVVQTRLWKPMALVQGDDKKAPPLSTIMMKGMGSTSVLSIFPDQGGEVSKPLEITIENHSTKHCFCIALPRRTPHFFEWRSSKSEEVQALGAYKRGWKLVWLRKDGGGGEIVAASALNNTMSLKKGLKFGFFNAGLDGTLGDTFHIAAVTTAMNDFEMFLSTNVAIVGNASTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBK9</accession>
    <name>A0A9P4PBK9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_100427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBK9"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040383343" description="Transglycosylase SLT domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30971" checksum="1A95D31550BC1A4C" modified="2023-09-13" version="1">MRSSQCIFFLLPFATAWPYSKHQGYGTSTIQLHENLQDAWYTKYTKDNQSEVTTLPTKNRLAVPGDPTRVYSCVGPRAEDFPGQDKWLTLDQLWAINEPVIETVNGGSTYNDDLQIAIKEVASDSKVDARLILAIIMQESSGNISIHCTETTACGLMQHRGSAPFSAYNPKISIKNMIEDGIYGTPGVPGFLSYFNCDASAPSELTWVNTQLINGNPYAAAHVYNTGHIDDVNLSTDKGKSNYYAHDILSRLQGWNGWKGGCEKSRGCDRLGFGKRHCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBU6</accession>
    <name>A0A9P4PBU6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_91300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBU6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="157" mass="17610" checksum="B0A65E75D3EBC0C8" modified="2023-09-13" version="1">MLPPKHSSPSLECSFTVAHPFQGYITLPVRWYRPSILSQLATAAQTQETQPHRTGNFHHRQLANPTTRTALVSRAPTTPPRCASDANSSVNIRNSSAHCLVSDILTDRSERYRPRPVCLDREFHFNPYRLFAAIEVRVRGRGLLPRSLDGGARLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBY8</accession>
    <name>A0A9P4PBY8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1769-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_435203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBY8"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="316" mass="35683" checksum="CF7C7A178615FCF8" modified="2023-09-13" version="1">MSHHEQYILKVTAGATYDTSKHEDVQVNTEKPVNISSEHLDARIQVRIKDYRGLPEGSPSTSPYFSTPQHPYDRYSISFAFTPKRSISGKDLVFGNDFEHPIRDRLPPLFDKAFGIVKWWIDPGLDGDVYGDNPYLYGALLSSINVLRIGNNPPQAPDAEEKAEGKAVIYEEGGEGDGIEVRAKYSIPATTSQRQKHFLNEAKRTDFTFEEGREYKCDFFNPYVDFNEFALKIGYGLPAISIIGHWDGQPLRTHSLRYVLKDRSTNTELFVVIFQLLPTEDAKKENGIESAEDMVKKVHGGDKVETKAADSDEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCP5</accession>
    <name>A0A9P4PCP5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_435361</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCP5"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="37"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2440576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="463" mass="50494" checksum="6DEC8A040841CFCE" modified="2023-09-13" version="1">MEKAIEELRSAIGEDAISTDDEDLLRHGYSEWSSINIDQLPVAVVYPQSTEEVSMIAKICLKYKIPMIPYSGGSSLEANFSAPYGGMSIDFTHMDKIVALHADDMDVVVQPSVSWMSLNEDIKDSGLFFPVDPGPSAKIGGMVGTSCSGTNAVRYGTMKDWVINLTVVLADGRIIKTRKRPRKSAAGYNLTNLFIGSEGTLGIVTEITLKLTVVPQETSVAVVTFPTIRDAAAAASKVMRAGIPVAAMEIMDDVQMGVVNKAGSTAKKWKEMPTMFFKFSGTKAGVQENVKLVKAIAKTHKSGDFEFAVDAQEQKTLWSARKESLWSMLALRREGDEVWSTDVAVPLSRLPDIIEVSKKELDSLGLFASILGHIGDGNFHESIMYNSKDPKERAAVEKCVKDMVDRALEMEGTCTGEHGIGLGKKDSLMKELGLDTINVMKSIKSALDPHWLMNPGKIMDFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCT2</accession>
    <name>A0A9P4PCT2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_365753</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCT2"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000146">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000239">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="182"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="514"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2441736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="560" mass="60988" checksum="F2C8DDE644F30915" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCW2</accession>
    <name>A0A9P4PCW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 105 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_500265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCW2"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="377" mass="42949" checksum="EEBFCCC810503324" modified="2023-09-13" version="1">MSTLTIHGLKSDDIHSAIQLLTHNLINIHDTTGEFLLKLEDGRVIDTKGWDGWEWTHGIGLYGLWHYYTLTGSQDTKDIMTGWFQKQLAKGTTKNINTMSPFLTLAYLYEDTGNRTYIPWLDTWAEWLMNGLPRTKFGGFQHETYNSFNKDELWDDTLMMSALPLAKIGLTLDRPEYVEEAKRQFILHCQYLFDTSTGLFFHGWKWEEGKDGSIGHNFARARWGRGNSWLTIVIPEFVELLRLQPGDPLREFLLGIFEAQCKSLVKYQGENGMWRTLIDLPLEDGNYEESSATAGFAYGMLKGVRKGFLGKEYIEPAVKAVKAVLGKINPEGELLEVSFGTGMGHDLGFYTAIKLTSMPYGQSMAIMMLGEFLRTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDV7</accession>
    <name>A0A9P4PDV7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_474640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDV7"/>
    <dbReference type="OrthoDB" id="5428055at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="625" mass="71701" checksum="1D5AEC901B2A0CF2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE24</accession>
    <name>A0A9P4PE24_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_444773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE24"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="278" mass="31124" checksum="EB3590AF274BD64C" modified="2023-09-13" version="1">MAALGLCTKTYVWSVVASSPRVQRFVVLGTHRCLHRSAFISVFALIAIGKLVTGLCLAQDHRGLPDWCIGARTAAELMALSYPTCVYYVCHLVCARCLSDTPHDPSFKRTVKIHLSRFYVETEYEYFFGLDISRASSLIDPLLQTSYWRCPLSASPLEQGHSPVAGNRRRLFHPDSLPAEDANRYGVVLGRPRQAARSMALCSRAPSHLQPISGWPCSWPSYARIGWPRAAVSYRRGDVLRPRIHARSIAPHTDRSCVFPSLFGYRSAVPGRRCTLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE52</accession>
    <name>A0A9P4PE52_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_364775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE52"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="156"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2442456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="549" mass="61643" checksum="27C705D49450B5A3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEI8</accession>
    <name>A0A9P4PEI8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_74145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEI8"/>
    <dbReference type="OrthoDB" id="4175349at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040191759" evidence="1">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="130" mass="13758" checksum="D0F8FCB9C8E995F2" modified="2023-09-13" version="1">MRTNSIILPLASLLHPTTSLAASFAPVNLTAPLNWIADSYLFPGNVIAGYNANLTAYDATSWGAHVLAACAGFTACTSALAYQATNSGSTGGRFWFGYAFRGGPTDESFYERDDDPYGGVTESAAWTMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEZ9</accession>
    <name>A0A9P4PEZ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_362160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEZ9"/>
    <dbReference type="OrthoDB" id="4188028at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="1091"/>
        </location>
    </feature>
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            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
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        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
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    </feature>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2443800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1091" mass="118896" checksum="B5C33A6B039690A7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4PF92_9PLEO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3946700at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="428" mass="47254" checksum="8A108A717CA01DE3" modified="2023-09-13" version="1">MGLPVWRAPSPEAPSQPLKDPTSLSRSPIRRRRPTRSPRARDFDVQTLLRSTARPARPYPPAPNVPAPNPQRREEHAHAPQDGGSSSRSYFSLVIDAAERRTGRHTLPALTPNFAPAIHVEHRRSAPVLRRTRLARSHTLRHAGDRSPVADEDVPVEADEGSGDNAVGFPPLRRMGRRTIADGPLPSSSLRESWSPATTLDGLGDRERSLSPVVDDHWETMLTSVAPDPLAPTAESSFASSAASASFSTSNPSSRAGSSNSNSNSASSSRTHLTIPSRRQSFSADFLRACDTSEDDSASDTEAEDEVLDSNSMRRRHTVGTASNGPPPPRGVYSRAIREQSRESTGYVRSFYGEVPFEHARRMEELFAAEERAATDEEMPLDQELRDARALLERLARREDVSDDFWASVGLRRPVADRVERIQQRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4PFD0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_522573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3784480at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040195572" evidence="1">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="142" mass="16508" checksum="98AFE5D7112543BF" modified="2023-09-13" version="1">MHFKQLAIIVPLLAIAGASPVAEPKPEVADVAARAQLEKDSDDVWLWKKRGAAQLEKDSDDVWLWKRADDSDDVWLWRRGQEATIKRAKLAKDSDDVWLWKKREAAKLEKDSDDIWLWKKREASEKSKKSNLVKDADDVWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG03</accession>
    <name>A0A9P4PG03_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_497356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG03"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2442458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="434" mass="47574" checksum="E9E47E6D9AA5785F" modified="2023-09-13" version="1">MAGNMMETHDAEQISLFDRSSSSSVLHASLSTEPPSIVRAEGHYLHTSTRTAIYDTLNGAAVSCIGDNHPRVKRAMQQQLNAVEYCFAPHFTTPAYEKLARFLVDSTNRQLQKVFVTGSGSEAIEATIKMARQFMTRDRSYYGNTLGALDILGYEAWRTIYKPLLSGYMSHVSPCYPYHDLRQGESTQAYVERLAQELEDEFQRVSPRTLGRMTEVYERRGALFILDGVFAGMGRTGSLHAWEGVVPDLQTVAKGLGAGYAPVGALMVGKKIVDVLDRGTKAFVHFQTYDGHPLACAAVYEVQQVIHDEGLVENCGKMGDYLGERLRAQLGTHPNVGDLRGRGLAWASELVKDRNTKEPFPVKQKVAPTIHAAGLQKFEIVLLPGGGVVDGVNGDLVVLAPAYDINREEVDLVVQRTATAIDCVLGPTTGVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHD2</accession>
    <name>A0A9P4PHD2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_522611</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHD2"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="11">
        <location>
            <begin position="333"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2442931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="830" mass="94047" checksum="9BFE77D81B2684FA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHW8</accession>
    <name>A0A9P4PHW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_521874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHW8"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="206" mass="21575" checksum="ED01C2E7785272C4" modified="2023-09-13" version="1">MKSLYVLALPTASAQYFSFGNYFSTGAVATNSWIRQATTTLVLPALNSPHTGNLGLWPGMGTKFDSGADGHLVQGLAISTVGGGSPCNFAASDVKWCVVASTFDDNYNDATTNFDQTVSVNGVKVSTLSTKSGHGAGRGTAMECQQANCGTVPERHWLNTTIVMNTADPNYKNTLGLNGASGNLVTADGGKTWTVADIKISKIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHY1</accession>
    <name>A0A9P4PHY1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_432739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHY1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="541" mass="58536" checksum="92EC6D53220853F0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI59</accession>
    <name>A0A9P4PI59_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_432517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI59"/>
    <dbReference type="OrthoDB" id="5330139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="174" mass="18617" checksum="371A9C2F1334D31E" modified="2023-09-13" version="1">MLARSRTTITRVVTFNALRPLRGAAAARAFHNATAEFTRLGPEGTLVTNKVSIRVGDPGEAYVCIPTEVGYALQAGGCLAHNSSALPKRPDRLTLSYFHDTQHFALDSSPGCPRLVVPQQLPRQSAANTSPATLYLYGVMHTIALDGTPDAEFAEIASTIIPEIGGALDRLKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIB0</accession>
    <name>A0A9P4PIB0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cse1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_390043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIB0"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000057">
        <property type="entry name" value="Exportin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2443673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="958" mass="108571" checksum="886BC92ABF6D7623" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIK9</accession>
    <name>A0A9P4PIK9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_359300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIK9"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="240"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="378" mass="41742" checksum="B387BE13535E7A4D" modified="2023-09-13" version="1">MVSFWPFKSIEDQTYFEKTLSTLSGKITRAAARNDAARQRSRRVRVMWTLWAGFAYIFAALFWSLVVGYKNWGRTEYTAVVGGPVLIYIVRTTTTRYYDWRISSTEAYIKALSKERETTIERLKESTKWNSTQQLLEKYGGQPPKPKAPADKKKDGPQKQAPAPGPRTGIAPPPTANIQRPSGQRPATPASTASPQGPPPPSALPPPDAISAEFAPNAFSAPELTRQYTASAATFTQSHWYDRILDALLGEDETQPKNRIALICTECRLVNGQAPPGARTLEDVGRWRCGGCSAWNGKEKAEEVVVERLVQGWEEERQAEEEKQTGDVVSRKVRGMEEVGAVPGEDEGSGVDVAEESVDETPVQGRATRSKTKAKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKJ5</accession>
    <name>A0A9P4PKJ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGT1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_34661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKJ5"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="636" mass="71388" checksum="9A4F8BE4FEF932D3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKX4</accession>
    <name>A0A9P4PKX4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_242776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKX4"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55577" checksum="6E093DA7A06CE783" modified="2023-09-13" version="1">MTEPAGGRTLARTRLAKPLATAYLLGLLSSTGPRLVHLLLLLAKGKLTLQAAWLQIVSTLRRALSLNRFPAFCATLIGGSTLMQLPLRTLAIQIGSLRGLGDRYIRLFVNFSAALISASAAFSLLNSRPQNGILTPAQTTPVSHLDLINPGPFDEPPENGSREVDNDTLDAKSLSRMDLAGRTMDLTLFAAIRAGDVLISQVCNRLPPSRARQVVSRGTPTALFCFSAATIMHAWFYSPSRLPQTYNRWISAAAELDHRLLLALRHARYGTWIYGKDTGMASLLGSMCRDYGLPEELGDPAKTIPIPCELVHMGCSKSCEKHALSRFWRGWVFAARMYAPLQLIVLARHVKKTGRMGDRLVGLNRSVVSKALVDTTRSSAFLGAFIAFFYYGVCLSRTRLGPKLFAPKTVTPQMWDSGLCVLGGCLLCGASILVEQSRKQMEIMFFVLPRAAATWFPRRYLPEHQWKEHITFALSTAIILTAAQEDPKRVRGVIGNILNAVLRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL28</accession>
    <name>A0A9P4PL28_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">P171DRAFT_292097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL28"/>
    <dbReference type="OrthoDB" id="5319830at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040139330" description="Mediator of RNA polymerase II transcription subunit 17" evidence="9">
        <location>
            <begin position="22"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2445258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="568" mass="63282" checksum="A4AFBC1A6651B20E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLG7</accession>
    <name>A0A9P4PLG7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperone/heat shock protein-like protein Hsp12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLG7"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="98" mass="9821" checksum="97A42C0FD6C00DF8" modified="2023-09-13" version="1">MSDLGRKGLGEQAKEKVTPDSQKSTLDKASESVSGLGDKAASSVQPEGDKSVTQKAGDATRSGGDSAQNEGKGVLANAQETLGNAAQSVQDAVSGNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM34</accession>
    <name>A0A9P4PM34_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM34"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040418878" evidence="1">
        <location>
            <begin position="24"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="479" mass="53125" checksum="1705DAA51E2ADADE" modified="2023-09-13" version="1">MQYSMKCSLTLPVLTYLCLTASALPTRPPKAPVCIIGGGPAGLTAAARLDAKGIESVVFEKQAAVGGKCQSYYDDEGIFHPLGAAFFSNASYPETLKVINESGVSIEEFALAGARDQFRFNITTGATDAVPALSPQALQLVAAEVPRYIQLWNRDFAPISTTNYKKGVPDSLTVSGEQWFKTNNFTVLPRLLVNPIALYGYGDIRVVPALYILQYFTPDILTGFLGQHSVYYTDFHKIWVEWLKKKGCKAKINLSHEVRCIDRSGKNPVVKYTAPKPYSNFYRWGKQECDSLIFAFPPSIANLERVGLDLTEEEQDVFSEVVTHNYYSSAVEFELPFGVSYIANSSNASVPPPNDMEPVAVLRLNAASNVSTSWSWGKDNVYESESTARDILQTTLSKINKDPRNLTAQAEPIDSDEIKAFKKWDYFPHFGSEALRNGAYGYLNRLQGCNKSFWASGLGGMEIVEWAIRAGQDVVDTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMB9</accession>
    <name>A0A9P4PMB9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_231440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMB9"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="304" mass="34777" checksum="5B39D0ADD4A0EBDF" modified="2023-09-13" version="1">MIQYHQKGIEIMSQQQQHKDPDVFPFQALPSEIRMAVYFELLVTDDRVLPTWRGARRATKQQKKMYISILLTCKMCRDEGLQVLYGENIFDFGEICNRPNNFSKPFLAHMGLHNASLIRIVFAEYSAACEELSQSDTSPISKPWHGPKSKMLLTVAHLRSFLSTFNISLPSLRLLAISIMPYGNDLATEDLLKLADPAVRLNMDWRVKWQDAKNKKGRLGKLVDGICEREKGLTKADYWADVDRWIGFRFAPPSSGREWLVYQGVRGREGDVIDRNEEEAGTEEQDSIEGSDAAKPVLVLRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMD1</accession>
    <name>A0A9P4PMD1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_520090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMD1"/>
    <dbReference type="OrthoDB" id="441890at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61954" checksum="5521310F409857DA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN13</accession>
    <name>A0A9P4PN13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_244198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN13"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="79" mass="9085" checksum="C836771A3182DAB1" modified="2023-09-13" version="1">MTREPTKRRSQCQRLYACERAIDHNSHGVVGFLTYMQMFLIDQSLPSCLSSKTRLRKPPLWNQVTQVLQCAPSGPHDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN49</accession>
    <name>A0A9P4PN49_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_430494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN49"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="996" mass="111442" checksum="A5D7270B81C82E17" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNL6</accession>
    <name>A0A9P4PNL6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_483328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNL6"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="367" mass="40694" checksum="89CC5F9585A51574" modified="2023-09-13" version="1">MFVPRALRLKGVKETQKRKPNQPTGSDVTEASNEDALVQAMQNASTNSAAPSPAAQSEEHLNETKASKKPKTTTTTTSSEYLAQLVAGIELIFTDYAHQDKEGAKWLEERYRTVDGEEKFIHLTAILEHPNISTLKPQATQPLLRQALQDIPSSTLDISPSGFYIRRRPSTYPAPFVPPNSFSVVDDEGLSFWDQRTIYVEPHIRHLCKTPAKVAHWLKEHGQLRTKWLPVQAVHTLYNSCAFVVLSGSVMHEDQWGKWRAAGKPEDWKVMTKVENLRRTEEYEKLVRGSRVEAGKQRQGSRGEDGQGDVRDALSAGAAGDDEQAASKKKKRKRGKSAAGAAHDEADTEAGEVASSGDGERSIKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP68</accession>
    <name>A0A9P4PP68_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2386201at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="2238" mass="250936" checksum="E03B75DDE6010237" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPI1</accession>
    <name>A0A9P4PPI1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_382969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPI1"/>
    <dbReference type="OrthoDB" id="2124077at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="50" mass="5559" checksum="849D313B24713552" modified="2023-09-13" version="1">MITDNQLYTLAVFLGSASMLLIVLYHFLEVNSEDHVPEEKPRAAVGKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ79</accession>
    <name>A0A9P4PQ79_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_207482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ79"/>
    <dbReference type="OrthoDB" id="3692961at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040310299" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22338" checksum="A34CB724CB754084" modified="2023-09-13" version="1">MRPTTLHLVLATLALAAAAPHAHPQDAPTSTLADPTIALPPSTSLNVPTTLLPTLSVPGNLSTTNPSKSTRHHFSHWEPIPIFSSACNCPSLATVQYPCWATDTLQRCNFEELHSFVCWTSAARGCPTPTRQCDKLYAPTPITGKHPCDLGQNTGGLEPAPTTVYITETSYATFVPTAAAAVKRGAATAAPLGRWQDMAWSPEHYGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQU2</accession>
    <name>A0A9P4PQU2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQU2"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF20">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="53"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="547" mass="58162" checksum="CD2A73A42BBD6B41" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS05</accession>
    <name>A0A9P4PS05_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7605 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_480221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS05"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7605" evidence="2">
        <location>
            <begin position="247"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="501" mass="57793" checksum="5FA2D02C2C34DD4B" modified="2023-09-13" version="1">MESSSWYSRSDVNLVLANSSNKLTIRHIIDEDECRRLKLDPRNQQHLQSLHHLEQNVKDEMQQLTKALKTPVNADFYEELMKKRGLYEYLNKYIQYSRTRIFATTRNTKIRKSLQDWYRGRTKEPNPLHIFCVSSKVNMEHVRGYAAAEFPRLSLAMTEIPALRSHIFSLAAKSSRVEQFQRHCVFIRVLLHEMELSCLGSRPMMKRDHLLKILLDVQMKQDHFEVLMADFVKNSVTPVVAKIDASTDAWLAVAQGFCKKWSSYTPQGFTAFLNHQGKWQTFKCGKADWNQDLMSSSRRGLQETFDVLREQECLSFRTRAIQHVNDLLKALEEKMKINLDISQSAAFRPFFGSFHQRKQEMTLIVNEVVNEMRTSLLAINNNAFNLGQTSPLTGRMLKIYEKAKAEKPRKGGALHVAKKARFSALVCHRTEGAYPAVKKFVEVALEKTVKSVESKLTTRCGAVLDAILRDFDSVCPESEDRGVLTLQRREISGRKVQESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS66</accession>
    <name>A0A9P4PS66_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_518918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS66"/>
    <dbReference type="OrthoDB" id="5429002at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040355041" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="19384" checksum="C47F3F0E0771633F" modified="2023-09-13" version="1">MRTFAFVSALAAVAFAQDSSSEAASSSVDPAPQTSYLQQTNSLGVITGGPPVATSQPAADTSIPSQPAADTSIPAQPAADTSIPLLVTSLPPFASIPAQHSGINTVVIPVGNNSTIQVVVSASNSTTIVYGSPNSASGSGARTTGTGKASGTGKASGTGADATGSDATGSESSQPTETPGAAANVQIASGFLGAAFLAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSI5</accession>
    <name>A0A9P4PSI5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_451073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSI5"/>
    <dbReference type="OrthoDB" id="3724200at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="13"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2450549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="502" mass="55644" checksum="55B73B11071ABCD1" modified="2023-09-13" version="1">MGKRLGAFRATYLVLLSCIGSFLFAYDTGIVGGVLTLQSFQRDMRFTAANKTQISSNSASLLQAGAFFACFLVWPFTARFGRRWSIALASLVFEVGAILQLFFPGNNVACWYAGRTISGFGIGIATTIIPMYSAEMAPKHLRGQLGTLFQGCFTLGVFTSYWVTYGATRMAPSTRQWRIPVGLQLLFGGLLGLGMLFTKESTRWLAKVGRHDEALQSLVWVRGGEYSQDIQAEINEINAGIAEEERQTQGVTWKEYTLPANRWRIILVITLQIGVQLTGNTSLAYFAPQFFAAVGAGNNSVLMSGFFGLCKVIACFFFLLFLVERIGRRRALLNGACLMAVLMLIVAIITATEPPTGKAGLTRSASAAIGMIYIEAMVYNISWGPVPWLYMSEIFPTRIREGAIATGTATQWLFNFVFSQITPHAINNLGWKTFLMFAIFNCSLVAYTWFFIKETKGRSLEDMELLFNPSGTQLDLEEARQKAYDTEEPAASIRHKKSDLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT69</accession>
    <name>A0A9P4PT69_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_353262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT69"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="23"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="408" mass="46986" checksum="E6619A39FAC4EFCB" modified="2023-09-13" version="1">MVFNSATTVLGSSDNIHTIANDFFITTHQRIPILSRHRFYNCLQSISNSPRADLVTLCLCIALVQHMPFEKRSSNMQSPLYVHVKSLVGLLEMAGEFTIDLLHCIVLVTHYELGHGLHPSAYLSLAASAKIARMMSLHKKPWQTDAGQGVESMLLEEQKRAWWAIVNLDRFIALYHGETLLVTEDPKISDILPIEDLLWSEGSEKDELASLITNAPSLDTPSHVTLGQMARECQIAHIVGRLIRHMSNPTLDPNFNREEYHQIERTLWAYMPLLADEELKVGRYCGAFAICNSALFILYEFKLSKIDKADPDETRRILQCMEDVSLRCITFAELSFTERTGSTLHEVHSLYCPYSLFQAAIVQYRIWKQNDDLNCKMRIDFMKNMLQEFARRWGYSCRDKYRRLLHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU35</accession>
    <name>A0A9P4PU35_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_350184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU35"/>
    <dbReference type="OrthoDB" id="3830006at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="421" mass="47589" checksum="8837EF33E2860F2B" modified="2023-09-13" version="1">MFPRRNSKTPQPDQRPSSGNSGGWLSPLEPSRSRSSSTSRSIRSISSKSPGKWIRHLKRSRSASINSAVGEDNLPLTREDFKQVEGWFDAFQKYNRLITNQVSGNSDFSAEELSKIQKTICEVEGGRFINDLPEALFDIALLWCPAGDMTRKAIGESSEPSWSWRAWNGAINFPFDPSSCPDVRRRGEAPVFFKSKITSFVLGPESGPERYTIMNRAMSLKLDPVSTQRPRVEYPTAGLQLLASEPPKVQSDTLRFTAQKVDASAFKMEQVYDEEKQPLLCTGLIDSQDRPCGVLMDYKKKIATHQQDGKLHYVLLSVNRRVPSTFSKSSNNISHPSGIPIWKDGRFLKEEEIGDPEDYDNDGEWRMYNVMLIQEFEAKTLDDGAIQEAFARRVAVGRIHEDAWNEAMETVPIKFSKIVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU94</accession>
    <name>A0A9P4PU94_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU94"/>
    <dbReference type="OrthoDB" id="3758316at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="169" mass="18549" checksum="36A7DC684228B8B8" modified="2023-09-13" version="1">MADEHTPSLIGQLLRAVGGWTTPSGKGLFMFRMMTFNASCAGICGVSVAFLSSVFYGPIGSIAFAIGSSIGWVAAAIYGWRTSVAHSLIAYDQYPKLMLIHMIRSFRLMGLERVKLESPDDVAKFRHRLVNDLRYKSMLVGAYETAAPLIDEIEARREAKVIAELAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUK6</accession>
    <name>A0A9P4PUK6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_141926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUK6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040423628" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11171" checksum="5A5AE11D697DDF34" modified="2023-09-13" version="1">MARGRCRVRTAVHLFILYRAPSLLAASSDVENCLLAYHVVLSTRDLSWGIKIYVLGRGKNPRHPLSLSFTSGVVRDWEVVRDQGILKLRVERRIVDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUL2</accession>
    <name>A0A9P4PUL2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_376006</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUL2"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040454926" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2451659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="447" mass="47637" checksum="C34ABB9C8162E149" modified="2023-09-13" version="1">MFVSFLSLSLATSLFAHSGAALDIDVKDQDSIKSAAKTIASGIVKLYNSHPKDTLTPGLFSDPYYWWEAGAVFGTLVDYSFLTGDSQYDDLLGEGLEHQIGEFDAFMPVNQTKNLGSDDQSTWGLAAMSAAENGFSTSKIGNLTWAQLATNVFDTQVQRWNDKTCDGGLNWQIYQFNNGYTYKNAISTGNFFLLATRLAKFTGNATYSEWAEKAFDWSEDIGLVDDYLVYDGASETTNCTQVNRIQWSNNNGLYLEAAAHMWNVTKGDDKWKKAVTGLVNTTVNVFVEKDVLTEVACEKNGKCNVDQKAFKGLAVRSYARAIASAPFISESLAPVLEASAKAAAKGCSEDNGGVKCQLRWTAQGEDAPGALGEAFSALAVVQALLVPEAKPLATGSSSNGTSTGSSTQNAPAASGSGKPAESEGGADALFVSRSLVVVVAALAVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUV5</accession>
    <name>A0A9P4PUV5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_426973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in rRNA-processing at A0, A1 and A2 sites and negatively regulates telomerase.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUV5"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF33">
        <property type="entry name" value="PROTEIN TMA23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2450642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="491" mass="53863" checksum="16861BE3B98E62F7" modified="2023-09-13" version="1">MNAEGLLRKQGWRGAGFSLDTSDRGIKKPLLISHKQDQLGLGKKKASHTTDDQWWMRAFDESLQNLGSGKTSTLTQIQEKGINHGGLYGFFVKGEGLQGSIEEKSSTPTSGTTTPPTSAEDESTDDSESDSESTSSDDAASDSSKMTKSKKGQSKRKREAEEDVPAAKKLKQETSGVKINARAQANANGEVRTGMGPIGAEAWPKLCAVTSRIDKQVKGRVKKNEKAGAYSDATNVSDPTNPGKKPGKKAVKQQRQKVIRAVKKEMAKALVVEAIVKGELPMLNPGNWSKEEILQNYGKIEKGIKAVENANKMSNKIERQAKREQRKEAKTKVASTNARSKIEARQQPTEQSIVEAHLSQLSPEKQVDYAARAAEKSQTLEEYTLRRIEKKEAKRGEKEPGNQGEKIAPVETKGKSEKIAPWKAKRMLKQEQKDNRAKLAGKLKTRHKVTKNAEMNEGKNEEGVEDKAEDKTFMEKAARFGAVAKPIAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVP0</accession>
    <name>A0A9P4PVP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS quinate transporter-like protein QutD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_151966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVP0"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF42">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2451082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="544" mass="59901" checksum="94F6456C370BFA69" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVT7</accession>
    <name>A0A9P4PVT7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_478264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVT7"/>
    <dbReference type="OrthoDB" id="5226159at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="275" mass="29218" checksum="6805F895F3C025FB" modified="2023-09-13" version="1">MGFKNAVKKIKRTLLCCRKEKKKPLLKIRPTTDVRRMDITEGMPDLTEADAKLIQEKATHDAYRLLSLQSHPPTQPATPTDPDPDPFASSAALSPTRTDPFASAAPSAAASTTHLPAPSPSPSSAHSWSRLNPLPAEDGAKDADPGVGKKIWDTTRRLSGLSLSRRSSTRDGTFYTPHKQGRHSEPAAGAAGAAGVVIELDDAHQPDEREDTKAGASVSVRGFEVVETVGGTAPGKGAPGRGRVVSSPLIERAGNAMELGESNDEEAERRPLVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVX5</accession>
    <name>A0A9P4PVX5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_515446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVX5"/>
    <dbReference type="OrthoDB" id="2107174at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050155">
        <property type="entry name" value="HAD-like_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434:SF1">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="249" mass="27842" checksum="1C54D7C3EF9F0F1E" modified="2023-09-13" version="1">MGKAKYILLDCDNTLCQSEHLAFEACAELTNKVLEKHGINDKRYTAESLLEDFVGYNFRRMLLALQPKHNFNMSDEELDEFVEAELGAVTQKLSEKAVECPGVTEQLEWLKKEGYPMSVVSTSAKSRVVASLRKTNLERFFTDEHVYSAATSLTPPSSKPDPAIYHHACKELGVKESEAITVEDSKSGATAAMRAGIPCIGYVGIYGIEDGKEKMEQMAKLLAEETKCLAIMYDWKEFPEVLKKVEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW12</accession>
    <name>A0A9P4PW12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_348244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW12"/>
    <dbReference type="OrthoDB" id="3686891at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="193" mass="22272" checksum="38BDCEDE6CDEACB7" modified="2023-09-13" version="1" fragment="single">MPQAGKSSSTKYGPYKARFDSSESASKHRKEATRFDRKPYRPPDTDYTIAEVERDRLYHVKRVYNAMTCGDAARDNKGSIAMKRWVHGAYYDSGLVEAYAHKVLDCLLLQAKEGFRGWVHNDYVADDRKGDDEDRDLTCEERLENIVRALQEEKTICEDVMNSACQIRMFVNAPKAYANRKYQNRVGNSKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWM3</accession>
    <name>A0A9P4PWM3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWM3"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="250" mass="27872" checksum="BD98EA4E054070B8" modified="2023-09-13" version="1">MKPPLRIAILEADTPPDDIVARYGKYGKVFRTLLEKAADELGEPGFSKDSLELSAYDVVTEQEYPDLDGVDAVLISGSKHNSFDNDPWILKLVEFTEKLLKQDRIRVIGVCFGHQIIGRAAGVKVGRSEGGWEVAVLPVELTEKGKEIFKQDTLSIHQMHRDVVFEYPEGVEALGGSPRCLVQGMYKKGRFISVQGHPEFTEAIVSYLVTMRNKQGIFNTEEAKDALDRVGNHHDGVAIAKAFLRFLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXJ1</accession>
    <name>A0A9P4PXJ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_427035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXJ1"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="116" mass="13148" checksum="53CC9878231B9593" modified="2023-09-13" version="1">MSAQNSAGIQTLLDAEREAQKIVQQAREYRTKRVKDARSEAQKEIEEYRKEKEDEFQKFEKEHSSGNQKAEDDAKKDTDGKVKEIDGIGKKSGSKVVEQLIEVASNAKPEPPRGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXY4</accession>
    <name>A0A9P4PXY4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_503746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXY4"/>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12285" checksum="CF920C952DD03521" modified="2023-09-13" version="1">MKELLSYKYVGSKFSFVVMGWCLKNNRFTADTHVYRIAGLSGWRPKEATREKTQSHLDAVIPVELKFKLHFFLIQHGRICPASRGVSKEKQRCEDQTEVRKQLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U669</accession>
    <name>A0A9P4U669_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3176 domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_318105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U669"/>
    <dbReference type="OrthoDB" id="5242705at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="79583" checksum="6B58CA32517EF2C1" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6C8</accession>
    <name>A0A9P4U6C8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_116194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6C8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="93" mass="10303" checksum="C0D478D0F9985727" modified="2023-09-13" version="1">MTSNFHPRSLRGGGTSVIRPFMPQHGFPGCSCLLGLTSMQGFTAVASHNCTLQFSDIGVFVRRRADGECEMKQSAWRADDKARLSWVLSDPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6H1</accession>
    <name>A0A9P4U6H1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_525136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4139202at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
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        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="195" mass="19885" checksum="C4D2F804B2DEF0EB" modified="2023-09-13" version="1">MSSMVVSAIPSSMGSCMTTYRNGPSALVTLKSTGSLNASLMTCKLSTSAAVKEATRTAGLHARAGGDDHSLSGELCSGDMLLDALVACAGVSLKAVATALGIPIASGTVTGEGDLDFRGTLGVDRMAPVGITGITGIRMGFEVVFGERESGPVTEGALGKLTERYCVVLQTPVKKPEISVKVVGRDSGGSRGMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6P7</accession>
    <name>A0A9P4U6P7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_524439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6P7"/>
    <dbReference type="OrthoDB" id="3600083at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="639" mass="65479" checksum="F22C486886578A42" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U799</accession>
    <name>A0A9P4U799_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_422187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U799"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="228"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2439581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="487" mass="53666" checksum="41E0065A61DA2804" modified="2023-09-13" version="1">MGDPQFAKFPDLQLAQHIFQLTNPSSSKSTKQASLKSVQDAIQEKKMAPLYRYLAHPVDGVLNAPGEGSAQQPAGHRRPSSSAATMLATKNPNLEVPLAWDEKLYESLKTENEKELDAIQKEEDEAAEKAGETEVQAARGKRAELYNRIGDKEKAIASYEAIFEKTGILGTKIDLVLAIIRVGLFFGDKILVKKTVERASALVESGGDWDRRNRLKAYHGLHLLTVRSHAQAAPLLLDSLSTFTSYELCNYSSLVIYAILAGSVSLKRVDFKSKVVDAPEIKAIVGGNQEDKLAAISGLASAGPAAGDEEMADASASTSTPTPTAVNLTTLGQQQDTSETSIDFNPLAKLVKSLYEGDYKNFFGALAEVEVNFLSQDRYLFEHRSWYVREMRLRGYQQLLQSYRVVGLQSMAHDFGVSVDFLDKDLAKFIAADRIPCTIDRVKGIIETNRPDDKNKQYADVVKQGDQLITKLQKYGQAVRLRGSERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7C6</accession>
    <name>A0A9P4U7C6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_117023</name>
    </gene>
    <organism evidence="3 4">
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7C6"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF274">
        <property type="entry name" value="ALPHA-CARBONIC ANHYDRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040324853" evidence="1">
        <location>
            <begin position="19"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="273" mass="30442" checksum="CFAB81A84CA7DE02" modified="2023-09-13" version="1">MLFSSLALLAASATAVVGCPQHSNNKRSHLQGRQTDPNANTTQNIWAYEAPFNWGKLSPEYRLCQTGTQQSPIALSLGNGLSLNHVPTFNYAGPITGNFFNWGYGPAFTVAHNGDWTSHPSFTYDNETLYLTGWHIHAPADHSVGGDRSKAEMHFVHVDAEGHEGAVLAFRLDPGNFNSTFFDQLPAMVGFDEMQTEESVEMDLSLAMEAVQYFNEFWTYQGSLTSPPCHEGIRWFIARQIMFTGVEQMQAILGASTYSARAEQEVWQHRINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8A4</accession>
    <name>A0A9P4U8A4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_500859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8A4"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="3">
        <location>
            <begin position="64"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="234"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="685" mass="74559" checksum="A1083E3B2CE1EEF2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8V7</accession>
    <name>A0A9P4U8V7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_445323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8V7"/>
    <dbReference type="OrthoDB" id="3799239at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="314" mass="35764" checksum="01F590D8AA38C496" modified="2023-09-13" version="1">MPPALTTAPEVNCLESPEQAPLFPPRPILLRFLEESRRLEQASNRVDPSKIIMGTASPTTISIDEANIMQLQRGRACETLTTNYHDLSCGHLVTTSTGFPTPYDLKAPCASNCCRSQPTTHGTLTPFVCPVCLETLIRRNYVKTYKEFTAAGYYPDPDPAENVKKWLCCSIRLVSNFGPRIVQGMSGLFLLGDEEKFLHVNFMPSVVSDMYNRWSFESRQHQRSRSRSHQRDIRMDRVSSRVHKDRAVSRRTRLKRDRSSSERRTLSRLHQDRSPLRATMRVDLDGLAERLGDTRIGLLEDGEVDDLLQRVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8X8</accession>
    <name>A0A9P4U8X8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S36, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_75781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8X8"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13080" checksum="9ED0C624EAE97E71" modified="2023-09-13" version="1">MNATKILQQGRQPMIRFLGKRTTPSKVDHTPHVHPASPSQSLPESFASYRQKAQQHGPLNQNSKFSTSHIGASPGSSLGPVEAGKGTFFDRSELPQRFQRMAWTEAEIEAIESGGASLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9K5</accession>
    <name>A0A9P4U9K5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_389828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9K5"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2443539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="127" mass="13515" checksum="1B03F8B1E198DAC6" modified="2023-09-13" version="1">MAGIKTIIGLSFVLAIGFLLVILSAALFHNYLTLLVVATYVIAPLPNWICGRAANPDDFMESAGSGVVDFGRFLTGFFVVMGIALPALLYHSATIQAGAAAMSVVGGLLIYGTIISFTMFFQEDQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAE6</accession>
    <name>A0A9P4UAE6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_53493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAE6"/>
    <dbReference type="OrthoDB" id="10361202at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="317" mass="36148" checksum="9CF42FB3FB09C4C2" modified="2023-09-13" version="1">MCQPTCIVKMSLCQLPLELLHEICSYVVFDTPESPTPPPLIQIVKPKGSRRLSHRYCILHASTKEIYEHFAHEMIDPVQSRGSMFLEFGTNHPYLSTPGPRKHEEKTLDISDKCGCKGDRPLSGLAGLSSIFSVLVTSRKLADGVRSWLYFQFVFDFHLDKTAAFGLFIANLLLGTKKLVRSIRLTMPIYNYSPAVAAIHPGWLHTRNGFDWTATIPNNVKDSFPNLRALHVNMWHWSRRFYGGRGSGCSGLAAPIEHEAWRMKALEPVLRFAVLPLEEVTVVVDNVWPRNEIWSGDPRVQERRELADWLRKQLLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB88</accession>
    <name>A0A9P4UB88_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_415635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB88"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="271"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2443856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="444" mass="49668" checksum="0D35F9F6DCB69921" modified="2023-09-13" version="1">MEDVKFARSHSNSPLPEAGNEPEDPLAPEIEEENGVNPPLGAPDQDMEVTEARDEMPDPDDVQEGGLSDNESVLSELDDQQFEEFDEGNIAIEERPAQVIDGENMNLIGVHKRKRAEGEGDAPKKKKKRADKPRRKKNRDDEVSGGDEASGARKARSRKKGRAADVDENDENLTPEQRRQRALDEQIKALMKPSGGSRRRKKDGIDLEGMADAEIEDMRRRMASAAEADNEGRKRGEPARHKLKLLPEVVTMLNKNSIKDSIVDPEINLLEAVRFFLEPLSDGSLPAYDIQKELFAALAKLPITKDSLVASGIGKVIMFYCKSKRPELMIRRQAERLYTDWTRPILKRSDDYRKKEFAQADYDPNNVQKRTADPQASQAAAQAAARNKALAVPTTYMRARAEAGPTTYTIVPKSNVVFNENNKGRSGDVDIMRKIRNNRGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBE2</accession>
    <name>A0A9P4UBE2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_520266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBE2"/>
    <dbReference type="OrthoDB" id="3799287at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="400" mass="45091" checksum="CC004F4F794C66FB" modified="2023-09-13" version="1">MYVPYSNFLVYPKPYCIYQPLQQRPPPGPPATDSAMCHYTIKFFECDHKTDDNVKGCSSWEQTGTHCDIDNPAVRKRKDCSIRSEKVTGLCPRCQSRERARILREQEERAQIEREQEEERARIKKKQEEERARIKREEAERARIEREYEEELLRRDLEKARIADREEQRRNAEAHEAHLRRVQEAADAAWRAEHKSKDATEIRTTTTHARTTYTTVANVEESSPSPSSPTPPPPPPPPPPPPPAPAPALPKTDYSQPPKDQNYGHHFIGMRRQPVHPSQKLAAEHPLSPTAPITPPTPRSPQTPVRRASTAKPSTPSSPLSPGGLSDMASGRQKLRTRPPPKEAPQGDFTDELKAMWERRGIKRETDEDGDDGITTASIVPSDSASQIDGGASKGRRGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCA3</accession>
    <name>A0A9P4UCA3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="12" type="ORF">P171DRAFT_410807</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCA3"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="45"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="120"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2446509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="474" mass="51113" checksum="D99921A715735049" modified="2023-09-13" version="1">MAELPAPLPQPASQGSTLSFTQGFLLGQLSIALIIFVFIKFFIFGELPSADDRALHLSSLRRARTLAHQSSLHQRTRSNSTTNPLRPKSSRAVIREAAGPGGPSVGAILAKTYYNVKGHQPESLDWFNVLIAQTIAQLRADARQDGAVLTSLTEVLNTGSKPAFLGDIKVTEIALGDEFPIFSNCRVMPAEDGFLSGAGSGGISGTEEGRLQARMDVDLSDIITLGIETTLVLNWPTDRVAVLPVALAVSVVRFSGTLAVSFIPSSSPPSTSANSPAPEDAEPPGSANAAGTGPGERSTPRRPTTLAFTFLDDYRLDLSVRSLVGSRSRLQDVPKIAQLIESRVHAWFDERAVEPRFQQIVLPSLWPRKKNTRGGEEGDADAGPDDEGMDVTSPTPDALRERESLPRTLEARIEAEGAKLREAEIRAGERTRDPSEGVRWRGEHLREQSRPTGRLGREWSARDVSSSMPGGMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD66</accession>
    <name>A0A9P4UD66_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2446001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD66"/>
    <dbReference type="OrthoDB" id="3801281at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="335" mass="36825" checksum="0F6EAA847B0D7043" modified="2023-09-13" version="1">MIPDASDDYVQYGFCSSLIERFTNTLGQIYEAETPEEQCSQPSFTANVWNSQTSSCHTSDLEHPFVTSPNEPPRYDLKGSFYDASAYRKFASLSGPQRTTIEERLCPQNTRNTSSATGTSFAIRLKASSLLCGISYQECKIGRGILAKECSCKKLDAEDLRRAFYFSRFGSSGNNVYGTRRLIYIPHLAVASVAALASLVSACCMHNYDFTHATTHPEHLAYLKHIPLLSLKEPTPTLFVTATIIHGLSTLTYYNTRRSDRFREAALVTGAVGGTCAGLWAGTTAENILVGVLPMATIASLLLFTGVNTVWEAFIRYGYCEKGKGDDLESQDTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDE3</accession>
    <name>A0A9P4UDE3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7871 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_431843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDE3"/>
    <dbReference type="OrthoDB" id="4140664at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="2">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7871" evidence="2">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="125" mass="13470" checksum="35FEADAD76190A91" modified="2023-09-13" version="1">MRRARSTYLKLQIPLLTFLKHSSSPLQLTNNTQSDNHTPSKPPFPNTPKMTCCGRNTGECVCAKEATCSCGKQPALQCTCGKAATENKLPTSTCQCGKRAEDSCTCGRSSDNGSSSLETDFTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDV9</accession>
    <name>A0A9P4UDV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PRP3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_358492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDV9"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="101"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="334"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="481" mass="53828" checksum="4AFF35E669DC3F09" modified="2023-09-13" version="1">MPEKRPFPGDHGDAVKRAKPGDPVAAAKAAAAAKAAEIRARIAARKPQSNGASPAPASTAANAAASASADRSHAAAALDTRRPVETKSKAPVPPTEEEKKNPYYDPKPVPGAKARVSRGLLFNSRGKYLEQASKLRAQNRLEEIKKTLALQARRAGLDENSERGFLVQPPPEVEWWDEGLLDEKTYDCVDDESKVKIDGDDSIITIYIQHPALVKAPQDKRLIETKPMYLTPKEQAKLRRMRRAEDLKEHQAKIRLGLEPPPPPKVKRGNMMRVMGEQAIADPTAVEMLVESQIAQRQDDHVKTNEERKLTKEQRIAKLEANQQKDAQKGLYMCVFKINTLAYGKHRYQIDQNAKQLALTGITIFNPKMCLVIVEGGIHSVNKYKKLMLNRIKWDENARPTEIQAEKQALEPKWMRSMDENGELKDHSHNTCILVFEGELKQHGFRKWGSKMCETDGEARQVLGRSKIDSMWALALAKGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE18</accession>
    <name>A0A9P4UE18_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_481498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE18"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="153" mass="16759" checksum="9E2589AFE8B27BC5" modified="2023-09-13" version="1">MSVAKPKYNLDEGNYRPGIEAENQITVPTRISHVPSATTITQLFPDLNGATTANAGSRSAQSTNFAITVAAADRQARYSPYRPWPSSRPAVETSLREILRVFESLKGVPGGSTRRASRHGILAFHVLWWCDTMGSRAEPAIQPPVISDSRKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEF1</accession>
    <name>A0A9P4UEF1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_470668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEF1"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="235" mass="27002" checksum="D37092C249542E4B" modified="2023-09-13" version="1">MDSHEHSKRTTLCDEEKFKDFSDVDSDDTPLVQHRSRSRFFHPVIIILSAVLVLIPLVYFTVATPKRGLKYDQCGTTADEARARGCVFEITGFTWLPIECRDTETEDEFLEYLSANELNIYRDTNYTDIVPIEEVRLGNGPGFFVGQQYHVTHCQFLLRKLHRAQMSGRMIDGQIMPTHHTVHCSEQTLSVVRNPEWRADAIQLSYTKFPYCGKPGGYNVGWDQKHGRPTAWTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEP1</accession>
    <name>A0A9P4UEP1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_483361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEP1"/>
    <dbReference type="OrthoDB" id="3748943at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="272" mass="30191" checksum="2E05A909FE1655B4" modified="2023-09-13" version="1">MSASSRVSRDAAEEREASPFGSFSPLNPVSPFDTATPFDTVSPFDRTSPRKRWVPPGWELSTTITSHGLKASEIVVVDSCPCQNHRQRYPEVEAIIQMFFRVCAIILNVIVLIIVRILDTDLQTLLQVHKLYGGIGFSLLLNTLELLSLGNPQSTLLIHLFPSLFPAIPSKSSPELQPRFPRLPSLALCICELVAMSGSFFSAITFLNPKVEDDALRNGCPVATCVTPEEYDMIYGYMIEAMVGLVHTGFFIMAFVHYAKRKAPGWLAKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF86</accession>
    <name>A0A9P4UF86_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF86"/>
    <dbReference type="OrthoDB" id="3796277at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="544" mass="61252" checksum="4827686391636B7F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFL6</accession>
    <name>A0A9P4UFL6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_482129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFL6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="177" mass="20279" checksum="D683641431C4197D" modified="2023-09-13" version="1">MISMFTGVPEKSQIQRHVPHPVSHNKTMVRRNHEDTDQHVDGEEEEEKGEEEEEEVEEVDEEWTPPSLHNAPGKFRLGRTYRMVSSAYIRKAFGVTITEADEASIHSYLKPGQKNKQYSLYHLWSYAIHVKGMSQDEADAVVDSEKNRKAASSARYKSYLSGDYAQGGDDFMNYMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGN3</accession>
    <name>A0A9P4UGN3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial inner-membrane-bound regulator-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_379938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGN3"/>
    <dbReference type="OrthoDB" id="5392646at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032741">
        <property type="entry name" value="Sls1_KH-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14611">
        <property type="entry name" value="KH_SLS1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLS1 N-terminal" evidence="3">
        <location>
            <begin position="143"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 first KH" evidence="2">
        <location>
            <begin position="283"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 C-terminal" evidence="4">
        <location>
            <begin position="452"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2449766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="869" mass="97283" checksum="3DC01C14ADD69DC3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH36</accession>
    <name>A0A9P4UH36_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH36"/>
    <dbReference type="OrthoDB" id="5220117at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="234" mass="26381" checksum="9A9B8D929726F1D7" modified="2023-09-13" version="1">MDDDWQAAAFGSRHMHNRVQNKSSRGNRPFDVYKTFGSYVCKCAAWKTRDDNNDDEKDITLELYRLSSNGEGVLGEICFPRALDAAVVLSGSRASLSRTVQRMEVDSDEEDEEDEDIEEGEEKDEHGSDEGATSDAEEPMVDPDFEEEPERFRNFEKNSFRQPKFWIRWNGVTEGSEVVTSDMGYVVFSGTDCRKFKGTITCGPLGWKDVAISGRKISGRGFSDVPISWNGQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHC0</accession>
    <name>A0A9P4UHC0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_426430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHC0"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2452029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="388" mass="43885" checksum="58567E1FCB010ABC" modified="2023-09-13" version="1">MAEVPIVLDGGTGFLKAGYAGQNFPDHQYPSIVGRPILRSEERDGDIVVKDIMCGDEAAAARSMLQITYPMENGIVKRWDDMQHLWDYTFFEKMHLDPTGRKILLTEPPMNPLKNREQMCEVMFERYDFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESTVLNHLTRRLDVAGRDVTRNLIALLLRRGYALNRTADFETVRQIKEKLCYVSYDLELDQRLSEDTTVLVESYTLPDGRVIRVGSERFEAPECLFQPHLVDVEQPGIAEFLFNTIQSADVDVRSSLYKAIVLSGGSSMYPGLPSRLEKELKQLWLTKVLGGNPERLNKFKVRIEDPPRRRHMVFLGGAVLANIMADKEDMWISKQEWEEQGTRALEKLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHI2</accession>
    <name>A0A9P4UHI2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heme oxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_426578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHI2"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2452209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="38141" checksum="5F9F419AF2ADB0BB" modified="2023-09-13" version="1">MARATVAQATLSSEINTATRSLHTELNKLITARIPFAIPPLASDPQLYTTGLLHFAHIFLTFESLWSDLLPTNAPGTAASPPTSPLLSFLLVNPYAEPELFTSPPAPQTLAFLQNLRPNGLARSGRIKKDLQYLSGLHPTDFDVMLAQYPGERVAEFCTHIRKSVGHKPHVLIAYAWCFYMAVFSGGRWIRGELVKAGPEFWSSGADAGSPDAGAPLVEKGLSLWSFPGTHDGEDIKQAFKERLLGAEALFTADERVDVIEEAKTIFKLCAGLVHELDGTLGTDLEQLKRVRAASPQSHQSQGKADKSEEVVTFQESYQAARTWLQRPEVTGAALALGCLACAVLLRLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI45</accession>
    <name>A0A9P4UI45_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_507731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UI45"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="140" mass="15016" checksum="2559E033B3A8F218" modified="2023-09-13" version="1">MLALAASRRSGDHPAYDEPDSETWGAAVGALPDLKMFELILEAIVPKEQQLGTVVECATKWKFPLKGTPYELVCDGKTGALQWSWTPRKVRDDRALAQQSGEQSQTQGHHHEAVHTLPDTLEPPSSAASSSGTLGPAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIL7</accession>
    <name>A0A9P4UIL7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_425813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIL7"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="79" mass="8559" checksum="5B4227ABB7C76888" modified="2023-09-13" version="1">MLGIVETIGGGSRIPQNVQHAGGACRLIEMRGPSRPQLSFTKVLYMAQRGQSVRVPTNNATLVICINTNTVAEQPLHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIR2</accession>
    <name>A0A9P4UIR2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_6050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIR2"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="316" mass="35068" checksum="904F54CC7ED73FFA" modified="2023-09-13" version="1">MDYNSSGKQLPQVVLFGDSLTEWSFDDSTQGFGWYLTDWYKGKAEIVNEGTTELLSCTPIDKAPLINPLDLLTVNIRLRRVKLTTPSLHISTNQFPSFTSEHVKREFSRLITQITAPYAPPTLLFTIFLGANDACFVGKTEYVPLPQFSDNIRSFVEEILTQDNLADAKIVLITPPPINVPEPFPSDDEDLGPAMAKALKGKDPKQDRGYMTYMSKKRYAEGIMSIAREYEGTGRVVGLDYWSALVNAGLADQGRPAEVDEDKFPGCGLSGAKEFGGGWFTDGLHLDKKAYNVLSRVLTETVIGKWPELSPERIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJX1</accession>
    <name>A0A9P4UJX1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_516011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJX1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2452138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="150" mass="17353" checksum="1A91827DD1988B1D" modified="2023-09-13" version="1" fragment="single">MEHRHHYQCSPRYHGSRPRHPWCRTCHLETPQSQARMAVRTTIRCPWVTTLSYRLGEPARFICVLPTQVYTVLLCPGEIGNDREPNEVAHWQQSEGDQTPFARQHDVQHLPLHLSPNFPQAHLAAFIAEIPNTNAMRFSLQPPQHHLSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6R3</accession>
    <name>A0A9P4P6R3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_491031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6R3"/>
    <dbReference type="OrthoDB" id="3799923at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="181" mass="19369" checksum="1B0EDC7736E1623A" modified="2023-09-13" version="1">MITDAELAEIEETLKKLPVSGVQKVSQTDFSNAESLLTPFTTAIDGVTITNFQPGESAPIPRDVEPQKLLQFRSFEIGSSVGASIIDSIKKAEYPAISRFLLVDLAGFEDNHSVASYSLDSIIGAGLRTCISKEYSYDMSIQQLLAPYLTIPALAETNCGVHDIGGGTQAAAALWVALLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6Z1</accession>
    <name>A0A9P4P6Z1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_436189</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6Z1"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031408">
        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09818">
        <property type="entry name" value="PIOX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034815">
        <property type="entry name" value="A_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF11">
        <property type="entry name" value="ALPHA-DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="3 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0611">Plant defense</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2439539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="524" mass="58990" checksum="8AE0D8606C71D7A4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6Z2</accession>
    <name>A0A9P4P6Z2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_437069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6Z2"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="76" mass="8700" checksum="D43677DDB6181BD4" modified="2023-09-13" version="1">MYWKSLIAVDYFLRTTFMTGDHRHSGRCLMDNNPNNLVQHRLSHYTAQVDCLGCDRRSKTYGGMVSVPTCSMNTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7P2</accession>
    <name>A0A9P4P7P2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_448898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7P2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="278" mass="31006" checksum="A872E0ADD497B37D" modified="2023-09-13" version="1">MPMHARVAGLFIRLVYMRGADLRQATDDLVLSDGGVKSSQVKSSQAKSSKQKKRARLNGTDDPKFTEEEEDQQLAQRYAISDVRAYRRDTKHVSVRTHLEAALREALQYSVQYRKHAASQPAGRPHEARADTAMHHVAQPRSDVGSVFQMLFRNVAARGHGCKRAKRSANGWNAGLRRRPPRSILKIHGPPIDDRQVQHAPSRLRLRSSIPAQPQFPRQPNSKPSATPTPTPTPTPTPSPSTSTSPDPIAATPRSIYRHYTRPKSPNTPHHPPISYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P886</accession>
    <name>A0A9P4P886_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_525612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P886"/>
    <dbReference type="OrthoDB" id="3798432at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="549" mass="61995" checksum="2C8215C28DA2F8A6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8D8</accession>
    <name>A0A9P4P8D8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_524396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8D8"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF124">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="66"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2440319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="422" mass="46892" checksum="6D74495767A6CA5B" modified="2023-09-13" version="1">MFESQDSPSRPLIARQFVDSDTGIIYLADPPNGTQRYTGDARPNLHSQLAATAISVTIVAFLTVALRVFTRIHVTKSGLAMDDYMVLIAMALSFGLLGMNFKHMAVGLGYHSWDIPMTDYMVPFQIYTLAGTMVYSLSLAFSKISILFLYLRLSTVRWFRLLVWILLGIVIAYAIIYNLMSLFGCRPIAASWDLSLATTAKCLDQLTKYMALSVLNIIIDVFELVLPIPIVVPLQMSNRQKASVCLMFATGIFVCAAALKRTLLLKPLMTAPDYTWAAVEQFQWCFVEVNAGVVCASVPALKSFFARYLPGLISSRLRSHDRSKNTDGYNTIEKGNQRPKAKKDVYEMTVVEDDVSSEKTVQPPNVNDDEARLWEGDGVRANASSNLSKPALSHVQTPTLGRDSEGSRIYVTSKTTVEYGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8M1</accession>
    <name>A0A9P4P8M1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_476662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8M1"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="143" mass="16840" checksum="AC96126032AFE2FB" modified="2023-09-13" version="1">MGSVVLPHLRTGWHVDQAILSEEDRLVVIRFGRDHDQDCMRQDEVLYKVADKVKNFAVIYLCDLDEVPDFKAMYELYDACTVMFFFRNKHMMCDFGTGNNNKLNWVLEDKQELIDIIETIYRGAKKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P910</accession>
    <name>A0A9P4P910_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF572-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_122898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P910"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="346" mass="38973" checksum="7ADB16A89651EE3A" modified="2023-09-13" version="1">MQGFNMGRYYPPDASAAPTFNAAPPLSARTKPNGALTVRFELPFAVWCAHCKPPAIVGQGVRFNAEKKKVGNYYSTPIWSFRMKHTACGGWWEIRTDPKNAEYVVVEGATRRNYGEEKEGEGEMRFLSAEERERRREDAFAMLEGKKDEAAEKKEHVKRVEELYEAAEVWRDPYDVNARLRREFREKRRGWKREDRVKEGMQEKFSFGYEIADATEADDVRAKMVEFGEGPVDEGVRDAMRRPLFTSVKAAMSDGGSKKKLKAEVAAEKSRQSLQQSLVGNTRASIDPFLTAETKSSSKLTLGIKRKRDEDAVVVVKAQPPATMSPSRNSEKAPALAAALVDYDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P970</accession>
    <name>A0A9P4P970_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_435493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P970"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="3">
        <location>
            <begin position="212"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="318" mass="33836" checksum="4AA875F9A7639098" modified="2023-09-13" version="1">MAASKAAVGVLSIGQMGFGFAKLLLAHGFHVITNVGDRSPATQERAKSASIECVSSDSELVAKADYILSIVPPMDAKATAERVLSVFTLEADPRPGKKESLYYADLNAVSPETARNISALFKQERRVIFIDGGIIGGPPAPTTDTVDWKRPGIPMSGPHPLHDAPIAGRELADTLNARYLNADIGTASGLKCTFAALSKGFTALALQSFTTAESLGVLPQLQDYISEYNPSAKARAEKGITGCPPKAYRWVEEMNQIGQCFEMDGGWPNSANVFRNVARVYEQLAVAVEERGGVEGMDDLSGALSALTKSLKDGDDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9F8</accession>
    <name>A0A9P4P9F8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_393653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9F8"/>
    <dbReference type="OrthoDB" id="3923199at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36640" checksum="E337D8575DA15009" modified="2023-09-13" version="1" fragment="single">MTVYFQHWTGEIRSIQLTPKGEWIGGTGSEVVVSDAKNATPISAVSYSLNDTSVWHIFYISKDGRVKQKVNSNSTNIWEDGPLNELNLTAYNAPNVGLQACWYGNYYGDSDSSKFPTRDGNNDTIPFSNSTPGMHLWYPTAESTFQQYGWYQGQDQWLEETTWNDMNAHAGVGCYSWQPGTTTYAMMVDTHDTATLWWRDTNSTRKPTDTHPIDSWENATRYAIPGVHPSSSLGFTEYLYAQMADGTVVGHDIDWAAEKTEGVAADAFTVGSARGAVPGLKGTHLSVTAVEDRSGGTSLYVFYQTRGDDLSVFTRDLDGGQWTQGELPIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9L4</accession>
    <name>A0A9P4P9L4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9L4"/>
    <dbReference type="OrthoDB" id="3789521at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="451" mass="50296" checksum="1DE828B9291334E7" modified="2023-09-13" version="1">MSVGKLACTSVGLGTPFGQVRHSSHLPPNPASSTRVCAPIVHETSLLFLNSTGQTAQLNSRHDENSPPQMRRVCTCPRQYETPPQKVAMSQTNNLCMKPLFDSADFVPASIDTNRFDGLVLCKCKGRYYCNKACRQADKNLHGPECKTIEYLAEPGDMAIAPTMIKPRDKGSAEIARQEDVIYHLTLVVHFAKQPKRARYITPFVELSGLEQKIQETVRDFSTVIPSGASLSELLNAPVSGLAGVEQVHIPCHGLEGSISFLIHYEKQNYIKYCYRSNFWSFGKLLYTVVVDTLKIRTDDQEKDEQYMTKVEVEATFASMDSAVECVSALVDRWDKEMGKHQGKIISVDRKSMCGVMISPNKKTELKHARIITRTLWQAGALNGKGGKAIMVVPEDRNSFAKRTRMMEHTEQEKTGTTSTGAAKLNNWKKRTAADMDRDVDAEDTSMYQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9W2</accession>
    <name>A0A9P4P9W2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">INSIG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_88927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9W2"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46136" checksum="1EA1E0595A17E3E7" modified="2023-09-13" version="1">MADDPLTTSSTQQPRIYRPIPRRNFSTQTDAPDSPAHAFVPSTPPLVAETQNRPSDFLAQLNARLLRTYNAGLNLNEDGDAEAAPPPRNKSLMNLTKSTLFGIYDDDDSTPVEQSVPETPWGTGTETPGRKHPGTNKWDSGTDSPALGLTMQPRRRNANNRDRPSRSPRHAPRPERKGIWKYTVSLGKLAALFLFGVTYGVIVSHLHDTRGLAAVRVEGVDRGNWIYLASWGVAGLVLGSCLPYVELTWGKNTVGDQEEEGAPEHETETSFSEQWNDVVRSVGAFLAVAFAIRRLPWQSTLQLTLTLALVNPALWYILDRTKPGFSYSLLVTSILTSFIFLSDPNILPSPLLPATINGTHTPSAARMQGQQDMFVGVVSYETLAVVTWVGSVLFCSCVCFGSIGRRLAVWDHHESGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA96</accession>
    <name>A0A9P4PA96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA96"/>
    <dbReference type="OrthoDB" id="10554879at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="334" mass="37572" checksum="9580733673C0F644" modified="2023-09-13" version="1">MASIFQSGAHVKLDHAFDLHLTSGIGLSSFTYSLRDFNDCSPRIENSRPRPTLTLPLNTAIDINTMNYVPTIGTDTSTLEHQGQRPQQIMLAEQQAKKRAKTKAMRAKCRQEQNAYVQEVLQEKRLEDMLSSMRGLELVGGETSKYAEDNAEITSHSGQTEQKEAETRAEHRLVLQARCDSKIKKRNEARGSSQQVIWREHREASKEQKKREKERGDQQSGLETLSSDAQRQGEMIPPSGRQSWREARQQARLIVSQGAKYVPTVPSAPQLHREPAFHLDHNTLPNMPMLSHTCHGSDGQAQVEMALRYGQGASAMPPRPRIQDQIGSPMEVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAL3</accession>
    <name>A0A9P4PAL3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_499635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAL3"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF4">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040509608" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="37"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="349" mass="37711" checksum="872071035761B95E" modified="2023-09-13" version="1">MQWATFTAVAALLAQNVNAQGNMLRFACSQLVVERTDPLVNPGMKYTPHLHQIVGGNSFNVSMDPNNDPAKLSTCTSCSFVQDKSNYWTAVMFFHHKNGSYIRVPQTGNGGPQGKLINKGGLDVYYIPSGKTTAFKKGFRMLAGSATNTDDNKVSKGNICHRCWTSPNENTFVGAQPCSGSDTVAIPSDPKCKMIRQTIIFPTCWDGKNLDSPDHQAHVAYGQGSGASGGGACPSTHPVKLPQIMYELMWNVTNFSDKSQWPTDGSKPFVYSMNLGGAAAHGDYVFGWEGDSLQKAMDNNCNLNNACPKAGLTTQTDAQYSACTKNQQAPEDVDGWLKALPMGEMAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC05</accession>
    <name>A0A9P4PC05_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe superoxide dismutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_394048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC05"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="228"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="293" mass="32461" checksum="A193DCF7B90F08C9" modified="2023-09-13" version="1">MIIRSLTRRPGAIQSLAQNACRAPYARRLHGVPSLLNHDELLKNGVPGLFSKKQFDIAYTQYQGHIVESLNVSTSGSEIENRDAKSLIVDCARNPMMAYTFNLASMAFNNHFFFRGLNTNPNISSTPSADLTPLINRSFTSLETLQETMILTADAMFGPGFVWLVQTPDAKEQPLKLLTTYIAGSPLSGAHNRKQPADLNTQNTTSYAGSFGAASRQKDNKPKKALGGVDVIPLLCVNTWEHVWLHDYGVAGKLSFLENWWNKIDWAQVQQNALFESNKSPSAGQGFRQFHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC25</accession>
    <name>A0A9P4PC25_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Potassium transport protein-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_524143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC25"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="672" mass="75730" checksum="29C4E2E96813178F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCQ6</accession>
    <name>A0A9P4PCQ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCQ6"/>
    <dbReference type="OrthoDB" id="3796222at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="459" mass="53325" checksum="4CBF7D2FC200DF4B" modified="2023-09-13" version="1">MVLGPRKPVSIPAYTSPTKPLEPPPTAALPTVTKWLIQEQYRRVFAKHLTRWASNHDSSSQFHGKIAVIASPNIDETYGLGKSVKCDLAYTCYTEVRKKIVVRLFPPRTAGARYALVVRSGSGWMSARDFFNKEHSLMIQAKTRSKAFRELWIKETRPRISTAAKQDVEVTSRRQKLAREAEPKNAITIGPVFHQFLKLPQEIQDIIWVNAAGLTGMFRPCRHRTSDVPVPHIHENFYPKSNSPITISTMLRVCKFVNTHMAPWIYRTTRFQFELTGFTNFLWISGPVNRENLRRVTFKFSSLAPLHCLRWLSPDPVFLLFDPPAYTSPHGLQYFWRCQIRDLARELNLHTLTLDLQGIDPTYVQMVVRILRRSFGSVEYVRFVEDGQGIDESHWRLQGLQERKSWRTMCREWFEAHKADGGHMSDQRRWKTPEDLEKDMDANMDFFDSVDDWQSVQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCX5</accession>
    <name>A0A9P4PCX5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_84509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCX5"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="80"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="283" mass="33237" checksum="8292A7E948B34231" modified="2023-09-13" version="1">MGSYSAEIHAFDNRFATPPCLPPAVEQLWKPIQWKAKQFLLKAPKRYARWRGRQDKCWRARLPRKIEQPAISLNSKTLDQLQSRFFQLPLELREEIYDYIFDGGIVRLDVQEKVDGKVVREKEPYRLRNMEPQQCLAILQACKKTYVEAAHLLYSTNTFKFLDLTTFVCFERLVPNHYWHRIQSICIAWDYDEIHYLFQYHQNPCPANEQTWNEVCQAISKMKGLGFLRVDLELYAEVVLQPLQEITAPAIFEFFVWNKRKAFAGRCGCGCGRAESFHGSGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PER3</accession>
    <name>A0A9P4PER3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin light chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_417799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PER3"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="272"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="997" mass="113031" checksum="0E17E4E36569BA85" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFQ1</accession>
    <name>A0A9P4PFQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_455986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFQ1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF25">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="364" mass="39881" checksum="5EFB5C6A02C1B9EE" modified="2023-09-13" version="1">MQRSTLGNFRAYWLGTVVLGGVLTPQSFTSSFRCDTAQKTRVNSLAVGLQQLGASLGARAVIQTIDNHTMGTFHAGRIIAGEGLGSATVVHLRGQIASLFQLKYTIAPPTKGQCNGRILSACNSAALLGLDMLTLKESTRWLTRKGRHEKSWETLKWVRASDSEEVAAEIDKNRIGVEIEAQLLEWLNFKRIFTAFAVFAAWQATGATAFAYFGQQYFELLLGPGDKYLLLAAISGAFEIVASETSIFFFSERVGRRQVLIWGAVFMAACQTSCAAVVKNTPAPSNGNTTPSDIATVALIHLFVIAYNFGRGPFPWPYISEIFPSRIRELGVAVGVSSQWLLNFIFLLVAPYMIEDMGWGTFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFW8</accession>
    <name>A0A9P4PFW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_487187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFW8"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="525" mass="57182" checksum="797B02B764977842" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHA5</accession>
    <name>A0A9P4PHA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_26586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHA5"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF53">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="511" mass="56357" checksum="F50535C744771282" modified="2023-09-13" version="1">MATVEPVYDFYKTGGNAETDNAGAEKILYNEQTTDSLASDSAEGFTWTEEEETAVRWKLDKVIVPLTTFLYLLCFLDRANVGNARIQGMGDDLKLVGVRFNWVTSIFYIIYIFVEVPSNILLKIIGPKYYLPLLVCGFGLVSMCSAFVHSFEGLLTARAFLGIFEGGVMPGIAFFITCFYKREELLLRVGIYVSAASLAGAFGGLLATALARIPPWGASGMIIHTWRNIFFFEGLITILVGLGAPYFMPKSPQECWFLNERERRIAVQRLVMKNSGDENEKVSPHHVTRSFLNINNYICALGFFLINITVQGISLFLPTILKDLGWTATKAQLYSVPPYVCACIVAIAVAFFSDKVNRRGIFLAAFTLLGITGFAILRWSTNPNIRYMGVFFITLGAFPGGPGFLSWAMNNASGPAVRAVSGAYVVTVGTAGGVLATWTYVASDAPRYHTGHTINLAGQIGVLVLSLAGIAYCKWENKQRDLGKRDHRLNGLSEAQIKDLGYRHPAFRYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHR1</accession>
    <name>A0A9P4PHR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_485828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHR1"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040161010" evidence="3">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="248" mass="26287" checksum="64CEF25CDB0BD863" modified="2023-09-13" version="1">MKFSTSLVSLALAASSAFAAPLEATVEKRDTTISCDAFGTLAEGGYTVYHNNWGSSHATSGSQCTYFKSLSGSTVAWSTKWTWAGAPIQVKSYSNVALEKVNKKLSAVSSIPSVWKWSQTSSGTPIADVSYDLWLAPTSGGENAYEIMIWLGTYGGAGPIGKAIATVTIGGASYKLFYGLNGDVKVYSFVASKNNGNFNGDLNLFFKYLTSSQGVPSSYYITSLQAGTEPFTGSNVVFKTSAYSISVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHV3</accession>
    <name>A0A9P4PHV3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_522801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHV3"/>
    <dbReference type="OrthoDB" id="10666523at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="360" mass="38925" checksum="B426CB667835BBF3" modified="2023-09-13" version="1">MGTLGTVAAILIIMISIVVFWYLSRKYGCCCGLIKWDKCNKKKQPDIEMQRVKPTISVAIQQQQPQRHAAPTHQQPQTHCTSEKRPQWQPPAHHQQQVHQPYYPPHPPQSSTQDLYPKQYAVPPQAHTKDMPAPHPQYQQQQLYIHVAPPPHPPSPYRAAFPPPPQHGYPILTPYPHPPHHEGETHRPSPPAENENFESSTPSPSLKAAPPSPPITKSRAKASTSKQSSKAATLDSLAPAKAKKSSKAATFDSLISGFPVAKPAKAKAATLDSFMTETPVEKRAKVKTSGAVTLDDLVADVTPAKAKKTKKKKEEGSNAFGGFDGFDDVDLGDAGWGDVGGGGGGGGGEEGEGEGGWVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ02</accession>
    <name>A0A9P4PJ02_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7029 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_277068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ02"/>
    <dbReference type="OrthoDB" id="5382170at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7029" evidence="2">
        <location>
            <begin position="36"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="602" mass="65270" checksum="37642AE37FF04312" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJJ7</accession>
    <name>A0A9P4PJJ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Piwi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_360820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJJ7"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="114"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="452" mass="50470" checksum="C6C0050D7C27672E" modified="2023-09-13" version="1" fragment="single">MSEPTVRYLGSNAEIGRSKKWNLDRKKFFNTANILTRQFLVLFPRTTGANGIYNDTARKYGLGLATQLRNTGIQYNGGGDVQNWFRCEVIDLDTQAGPEEEFKTRLGKLSLDTLVCFVNPSKDSRYSTYFDHFKRVAEQECGLQTVCITHATLTAQKDTTQYFANVAMKVNLKLRNYNHAIATENRLLGTSKVAGVDLNDTIVLGADVTHTQKDSDPGSFSLAALVGSIDGTLGQFYGSMTYLDRNSEAIAQENMSTMAKQRLEAFYKKSGRLPANILFYRDGVDEGQYARVQTTEAQGIKQGYRAFAESIGISTVPKITTVIVTKRHHTRFYPSSVSNATESSRRTNCSPGTCVDSGVTHPNYFEFYLQSHHPIQGTARPARYSVLENGMNLTEQALQNFTYEICYSYVRATLPVGYAPPAYYADRLCERARCYFADLLKSQDAPDDSGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKA0</accession>
    <name>A0A9P4PKA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_285127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKA0"/>
    <dbReference type="OrthoDB" id="5420711at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="330" mass="36750" checksum="5814B63908EB74F6" modified="2023-09-13" version="1">MAEPTSPLLRLPFEIRLVIYEYLLFPSAIPSSSHSTSVANILPDFHTYHSSDTNDTPFTLAVRTIDPYAGVNSSRGWRLRSTYYVRTGKHPTQYCLARVVYLPYSQNEGIITSASGPFLATTTPTTYRVLLSPYTAHLRHTVPSLLSLNHQIHAEAAKVLYTNYTFSFHTSIEAAVPFFSDLTPVARDAVRHVALTKKGLPYTKEFDRLEWAALCVYLARNVCPSNLILSIIAGRQGDDGWDDVAPISKDAFALMQRMKKGWGSSVGGADLEWVDQLFEIKGLREVNIKALVEHCPPAVSEAMAFWVAFSKSVEGGFGEWVREVMVEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKA1</accession>
    <name>A0A9P4PKA1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_266326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKA1"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11854">
        <property type="entry name" value="SH3_Fus1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035521">
        <property type="entry name" value="Fus1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="401"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2445497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="624" mass="64492" checksum="D8E2FBF15BE99DD5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKJ2</accession>
    <name>A0A9P4PKJ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_463326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKJ2"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="240"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2444614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="429" mass="47003" checksum="31163CD34AC55D81" modified="2023-09-13" version="1">MATISELTQEISSKAAELEQLLNEASLAQPSFSEHSAHDFDSRHSQNTNSEALRQARNALINATQGLTQLTMGPIDYLCSLSWSAAKVANLGSLVRLEIPRRIPLGKTRNLDDLVAEIGLPAIVTARVIRYAIANGIFYEDPVNVIGHTASSAKLASDRDLHNYCLMWSAEISSHLVKLPEALYKKQVYGPKGPESAANLAFPEFVDIFEYFEKRTDAAQRYSLYLGSRAKIPCWSADFLIGAWDWDSIGSGTVVDVGGSAGSTSVILAQAFPFLRLVSEDVAPAALKEGEAIALELQLGSRISFVQHDFFKPQKISAKVYIFKSILHDWPDATCVKIIKALLPALESGAHVLIAETLMPAEPALRTNAWDFEGRRVEDQIMIAGHAAHERTLEQFKAIFAEASDSFHFVGAKEGADGSMFSLIDFKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKP2</accession>
    <name>A0A9P4PKP2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine-rich transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_472451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYSTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKP2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028144">
        <property type="entry name" value="CYSTM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12734">
        <property type="entry name" value="CYSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich transmembrane" evidence="5">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2445772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="141" mass="14582" checksum="EBBCE456545ED02B" modified="2023-09-13" version="1">MASNKYDAPAGAPPAYPQSPPPAHHDAGPYQPPAPYYGNSPAPPNDYYGASPNPYAQGPGPYGPPQGEYGPPQGQYGQGPPPQGQYGQPGYGPPQQGMYYQQGPPPPGGYYDNQRKGGASDGICAGLFAALACCCCLDCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKT4</accession>
    <name>A0A9P4PKT4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_431873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKT4"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000072">
        <property type="entry name" value="Cyclin Pch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000201">
        <property type="entry name" value="Cyclin pch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="61"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="180"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2445123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="340" mass="38504" checksum="E9E8B157A84E2A0C" modified="2023-09-13" version="1">MVSATVTPAPPVRERPRPPPPAVVEAEEQWIFTEDELLQAPSIVDGMSPEEERALRRKGVNFILQVGMMLKLPQTTLSTAAIFFNRYLMRNSLKPRPGYKPLHHYQVAATALFLATKVEENVRKMKEIVVACVRVALKDPNKLVDEQTKDFWKWRDTILYSEDVLLESLSFDMNIEPPYKTMYDMLKYYNVEHNKRLRNAAWAFLSDSCLTQLCLLFTSRAIAAASIYAGARMVDLELPEEDGKPWWEIQCVKLRDIRRACNHMADIYETVPSKDGEPNIYAGLRSPEDGSYFDTPTPGQHPMPEPELDPEPEPANGNGKGKEDANGGDEVMSEEGELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLE0</accession>
    <name>A0A9P4PLE0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_357203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLE0"/>
    <dbReference type="OrthoDB" id="5429716at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="253" mass="25778" checksum="0E8F19B37E5B38D8" modified="2023-09-13" version="1" fragment="single">MRLSPDWRRQAEPIPAPTRVNLGPLTTVFVPPPYCSRAALAGSQAALGQSCNAVDKTASAADDTGCWPRATAYPADTKSKLAGLGFYSPGLTCPQGHYSACTAVSTSKGQTAAAPQVTGKFQFPLVAGETAVGCCPTGYTCGANGGFQTCHQVATQTSFDAMTCSGMSGSNLDAFQVPVTVDGETIATMDLYAPMIQINHMATDLPDTSSEASKTPAATVESTGAAEESRSRTKSGVTAGVTSSATATATAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMG2</accession>
    <name>A0A9P4PMG2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3 8">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_237687</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMG2"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="11">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="100"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="10">
        <location>
            <begin position="547"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2446702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="667" mass="74028" checksum="2FA42DB9A3F72829" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNV2</accession>
    <name>A0A9P4PNV2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P171DRAFT_482158</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 18"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNV2"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2447417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="416" mass="44437" checksum="1EDB04616ADBFFA6" modified="2023-09-13" version="1">MSLSNKLSISDVDVKGKRVLVRVDFNVPLNGDKITNNQRIVGALPTIKYAVEHGAKVVVLMSHLGRPDGKVNPKYSLKPVVPELEKLLGTKVTFTEDCVGKQVEDTVNSASDGQIILLENLRFHAEEEGSSKDAEGKKVKADKAKVEEFRKGLTALGDVYINDAFGTAHRAHSSMVGVDLPQKASGFLVKKELEYFAKALENPARPFLAILGGAKVSDKIQLIDNLLDKVDTLIICGGMSFTFKKTLENVNIGDSLFDANGAKTVGDLVEKAKKNNVKIVLPVDYITADKFDKDAQTGYAEDKDGIPDGWMGLDCGEKSIKLYKAAIDEAKTILWNGPPGVFEFEKFANGTKATLDATVAAAQSGKIVIIGGGDTATVAAKYGVEDKLSHVSTGGGASLELLEGKDLPGVSALSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP15</accession>
    <name>A0A9P4PP15_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_385708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP15"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001558">
        <property type="entry name" value="Ribosome biogenesis GTPase Lsg1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="177"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="642"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="673" mass="76021" checksum="543F25980F842DDD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPF1</accession>
    <name>A0A9P4PPF1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_518317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPF1"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="393"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="635" mass="69279" checksum="ABEC3B6DE552F6E9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ17</accession>
    <name>A0A9P4PQ17_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="6">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="6">EF-G2mt</shortName>
            <shortName evidence="6">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MEF2</name>
        <name evidence="8" type="ORF">P171DRAFT_428260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ17"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000106">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000007">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="37"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="187"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="884" mass="95913" checksum="618AC4A93C95BE20" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQF8</accession>
    <name>A0A9P4PQF8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_429130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQF8"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="107"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2447493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="652" mass="71781" checksum="E725E3808603875E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQK6</accession>
    <name>A0A9P4PQK6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_480564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFB5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQK6"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="111" mass="12708" checksum="3852928405D500C5" modified="2023-09-13" version="1">MAIRVHASAAHLRTWTPSWAARQHLNSVAATSSRPRLSMVKAVPGTLVKCDPSIKALILNLDKDFGNRYVIEDLGDEEHLLVKNDQIHELKRRVQEEISKRIETRKDEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR01</accession>
    <name>A0A9P4PR01_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_429298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR01"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="90"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="189" mass="20872" checksum="87943CBD1937313D" modified="2023-09-13" version="1">MFKKDITSGAKSKVKSSVQRTIRQKVLDTYPLLEPYIEDLMPKKEQLDLVKLPDRVSLYTLQSTPLFFQHMDDTILPHLAIVHRYPNCFPRLRIDRGAIRFVLSGATLMAPGLTSPGGRLPGDPEDTEGIYGKEELEAGTPVVIEAEGKETACMVGVLKVGTAEMKKTKKGQACEAGHYLGDGLWTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRF6</accession>
    <name>A0A9P4PRF6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3253 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_202884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRF6"/>
    <dbReference type="OrthoDB" id="2563170at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021660">
        <property type="entry name" value="DUF3253"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11625">
        <property type="entry name" value="DUF3253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12490" checksum="8602CB712E45E2C9" modified="2023-09-13" version="1">MILDHDQEEILRKHLKALLGKRPFPKTICPSEVARALDQEELDKLECYDWRDCMENIRGLCWEMREYGVVEVLQKGEVVKAKSIDDIVGPIRVRYHPDHRRQEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRM6</accession>
    <name>A0A9P4PRM6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_439738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRM6"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2449161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="327" mass="35787" checksum="387AF8B9D5476D9C" modified="2023-09-13" version="1">MTSSSNRPSVVPQQDLESFQDHLNKSTRILALLGAGLSASSGLPTFRGAGGLWRTHDATQLATPGAFSADPGLVWQFYSYRRHMALKAKPNPAHYALAELAKKKETFLTLSQNVDGLSPRANHPEESLKLLHGSLFDVKCSDFFCNYLEKNNYTDPIVPALAIPTSEEDPTTTSALASRELDIADENVPIPELSYKHLPKCPKCKRGLLRPGVVWFGEMLPEKVLDDIEEWIQKENKIDLIMVIGTSAKVYPAAGFVDRARAKGARVAIINMDKNDVPASGLDKRDWFFQGDAARILPEILSNVIGELKETPDAAADADNAVTEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRP5</accession>
    <name>A0A9P4PRP5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_229199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRP5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="84" mass="9191" checksum="BFF076B562C79149" modified="2023-09-13" version="1">MEGDGICPADYLWYWCGTGTIFAGDISAGCCFLCTARQAKGQYLNIVNNSHEQKNTTSQCRLCVCARCEVRNSTSSLSISFSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS24</accession>
    <name>A0A9P4PS24_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_506722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS24"/>
    <dbReference type="OrthoDB" id="3892448at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="124" mass="14014" checksum="67ADBADF9CCD48B0" modified="2023-09-13" version="1">MILAPSESPILLGSLREGDNRLAEAETRLYSKKTTSGLDWQTLTSGHLVDFLLRHAETLKCVELDHMHLAEGKWPECFSKFAGKLPKLHLLEVRGDFWHEWGEKVIGNSTALENDPSNKKSTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSN7</accession>
    <name>A0A9P4PSN7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_428679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSN7"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="96"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="336" mass="37511" checksum="1329D7281C961234" modified="2023-09-13" version="1">MATRTPVDASTKNSTIQITTRHDRSVLMFLLHMLLRPFHNHVGRSGHARPEGSVKLKPSPIGTKRSNVTQRVVCDIHVYDIVAKEPAQSDTKKRIYYFAGGGWQTPPSSQHWGMCSRMAQVVPGATVSLVSYPLAPKNPAKDAFPWLMRFYREVMKTAEEVNEKIILAGDSSGANIVLSLILEALREDDQNTDLEEKSAPHPIAIFATCPSTDLTRNNPDIEKTAKYDPMLTPKFIKSTAKAWCGDMDPSDRRVSPVNADISLLKKYGVHVHGITAGHDILSPDGVLFRKKLQENGVSGQWLHWEKQMHCFVLTYPYGLREAKEAVDWVGDVLKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSQ3</accession>
    <name>A0A9P4PSQ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_503247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000159">
        <property type="entry name" value="p-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000160">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="479"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1354"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1633"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1909"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1181"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2141"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2260"/>
            <end position="2325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1181"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1233"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1271"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2175"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2198"/>
            <end position="2214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="2366" mass="263537" checksum="963088BABECCFC61" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSV8</accession>
    <name>A0A9P4PSV8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_470068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSV8"/>
    <dbReference type="OrthoDB" id="5273647at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="47"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="337" mass="37488" checksum="406E7251D2EA40BF" modified="2023-09-13" version="1" fragment="single">MTSYPSIDAFVQRDAVMAQTITSEDCGPMIARVSIAVYAVAVFFVALRLFTRGWLIRKFGLDDLLIGIALSVGAGETVALQLQVYHGQKQQPGDAEKDEVSKVLMYKYVNMLMYYLANGAVKLSILVLYYRICSLQKGLPWFLRGPVVWTMWVAIMAFTLSTLFVEMFSCLPVSAIFDLENPTRRCIAWVPFYLSQAGIDVFINLALLLFPLPFLGILKIDRKQRYALVLVFSIGLLPLVASVIRLCQITIAVGTEARMRPSGDASWEGRWIPLWSQIEVDVSIVAASLPSLSPLLKQMWSSFAHSRTLSPSHVPTLIESGFNNRGAKAQGLQKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT32</accession>
    <name>A0A9P4PT32_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_470205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT32"/>
    <dbReference type="OrthoDB" id="2148716at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="162" mass="17995" checksum="E32D04F4C6E7FCD5" modified="2023-09-13" version="1">MPPTTTLPSLTPREAIADALSRCVLGIDTNSRPLFESACVKDETMTISIGPIVLEGWPAISAYMERVFHLITTHIISNVRIAVEDGADTATLTAHAISYHVREEDALKVEDTSYTASSLYDIEMVKDAGDGLWKIRRWGFEVLWTTGKRSVMVPEEEEVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTI7</accession>
    <name>A0A9P4PTI7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTI7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="77" mass="9030" checksum="5C81CA150319C572" modified="2023-09-13" version="1">MSYTLEFDSDDYIPVYHNEFTITGSIKAHPKLWFCGACIWVLSCVLVWKLMLIALERASRPKTSRRMWTTGKRMKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTW8</accession>
    <name>A0A9P4PTW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_135936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTW8"/>
    <dbReference type="OrthoDB" id="10609446at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="166" mass="18434" checksum="124DAF3DBCC454D1" modified="2023-09-13" version="1">MRYYLGVTDKEAGKIRPHRFRRNCQSSFDRPVQSGFVNIADRAASSESTANIIIPLNKTHYLTPNIQSRNFAITSENQTLSDTAKIRMSSTLTFEIAHSLFHWMRGDISPQVLAAKLQRTSSTASVSSSGSSMSDGVEILAFAERRSRVRHRKWSSGASGRAVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU30</accession>
    <name>A0A9P4PU30_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_349430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU30"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="505" mass="56156" checksum="82A9351C5E0EFE3F" modified="2023-09-13" version="1">MGGQTETSHLDDLKGGDARQIAERGQVATDIYGHSLVQFDPKAESRLRWKIDLYIVPTVALLYLFCFIDRANIGNAKIAGLEKDLGMTGYDYNMVLSIFYISYIVFEIPSNMACKWLGPGWFIPLISLGFGICSLGTAFVQSKAAICGVRFLLGIFEAGMLPGIAYYMSRWYRRSELAFRLSLYIVMAPLAGAFGGLLASAILKLDSFGSLHKWRMIFAIEGIITCGLSLVAFFTLTDRPETARWLTQEEKDLAHARVKSERVGTTEVLDRIDKTKTLRGILSPVTLTISFIFLLNNITVQGLAFFAPTIVQTIYPKDTVISQQLHTVPPYVVGGFFTLLFPFLSWRFDRRLILFIVSAPLIMIGYTMFLASSSAQTRYGATFLIASGAFAFGALCNAQVSANVVSDTARASAIGTTVMFGNVGGLISTWSFLPFDKPNYHIGNGLNLATSSCILLLSTGLLFWMKWDNRKREGRREGVDEELAGLTLQEQQDLDWKHPSFRWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUB1</accession>
    <name>A0A9P4PUB1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_138626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUB1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="170" mass="19226" checksum="740D431722346A3F" modified="2023-09-13" version="1">MTEARGCRYITIQLKIVSEVNLSLATYSRTNYASTRRPLRSGFASLPSPHKSAAGNWHIENDRRTPGMRLIRSVGSPCRLRHLRNKLSTCTPQPQKPDQANPIRFHSNSRKIMASHRKNIRWPPGCASKPLLNSPSIKIMSSILGAVRSVSNQMMWVSTQRRLCNAFVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUE8</accession>
    <name>A0A9P4PUE8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_516287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUE8"/>
    <dbReference type="OrthoDB" id="3735213at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040166245" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27023" checksum="C037E722136EA836" modified="2023-09-13" version="1">MRTRVITQVLFVGATAALLNFVSARQDPLPPLECPETWLFNIASFSGPGCPIARQASRDTRTQRSGLGLPPRPSVGAGVRESKTYCEMQLKWGEMKGDTYPIEIPLNQAAWKLKMHRNGTTIEAGYAIDEGVRADWRFTYWMDEADDNAKLVDEIAVVGPLINNAPPVKQLDWSQADKKTLEWTAPQCGVAYIKVRVDLELIAENARANGTVFPTRVGSGIDDDYGWPGPLLGASHDFEPCERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV12</accession>
    <name>A0A9P4PV12_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_200435</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV12"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2449818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="383" mass="42085" checksum="57015DC3B74D3D8B" modified="2023-09-13" version="1">MANSSSSHLVATLFYKSNQPNFFPHPDASPRSPTDALAPASLESLRDGGAPTDNLEEYPLEPPTPGPNPLDHLYGSYISQSCLTDFVVLLRDIIPGIEESGIAFRQLSEEKLARVVEVRFPTAGADLEVLRRNEHVSRFEREWNLEIVWQADTVHRRYKRLAVFDMDSTLIQQEVIDLIASLIGVEDQVSAITAAAMNGELDFEASLRARCKLLKGVPSSVWETLKVRITLNDGVPELITALKRLGFKTAVLSGGFTPLAEWMGQKLGLDYAFANHLVVSEDGKELTGELTGEIVHAEKKRQHVLEIAEKEGILLDQVVCIGDGANDLPMMGVAGLGVAFHAKPKVQMQAPARLNSKSMLDVLYLFGISKEEQEALLDSTKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV65</accession>
    <name>A0A9P4PV65_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_480964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV65"/>
    <dbReference type="OrthoDB" id="3791564at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="313" mass="35388" checksum="583F3B38B17B7E00" modified="2023-09-13" version="1">MSEHPLPALPREDQYEVQLEPRLETHYQTRCERTSILKESGETYALFDDTSEIDIRPYSYPDDAHHGLSTFLHASTLPDDLPSQKPSGSVEHDAQTYCSSAADSQRTQRDYIERGASRAPEKLDNSLWSTSNDTALPSTPCRASCDAVCDYVPDATSVQQCIYCPSDANFDPRCDAPMESDDELFRETLVRFADAHTILCTPPPPTPPPHLTFSSASSLPSAPPRLTPYGPRIPPWGSTENLDRERRLRTDIRTFEDTLDEQFDDRERLRKEAEARNEKRRTEGEELRELVLGIYPEMEAGQKERGCCLCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVC0</accession>
    <name>A0A9P4PVC0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_516718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVC0"/>
    <dbReference type="OrthoDB" id="5289641at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697:SF2">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="179" mass="19875" checksum="D14E2FFFCDFEDE36" modified="2023-09-13" version="1">MASSIDQSSDISFEDDVHSTVLLTPTTTVADPQDFPERPVKVKTSIPCRGKTFLIRDTKSGHVLSLSDGKISLLPSNQLGSAIYWSCHETNGWLGFKNLASGEYLSYYPKEHLTTQPAHRALEYFCLRMVRKGGYVMLAQVEGGEKLWPVQVLADQGLQRLAKADIAVEKGVTWEFIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVF4</accession>
    <name>A0A9P4PVF4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_350322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVF4"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="659" mass="74114" checksum="558332082A0EF341" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVH3</accession>
    <name>A0A9P4PVH3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uracil-5-carboxylate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_376843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVH3"/>
    <dbReference type="OrthoDB" id="191270at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000055">
        <property type="entry name" value="Uracil-5-carboxylate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="4"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2452139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="362" mass="39860" checksum="48186694912058E4" modified="2023-09-13" version="1">MPIVDIHTHIYPPSYVDLLRTRQTVPYVRNFEDAPDSSRLIILPGEDDPSTPSTSRGRPIGPEYYDIAQKIAFMDQHKIDKSVISLANPWLDFLPAEEAGEAARKINDDVDKICAGYPGRLYAFGTLPLSADADTIVKEVERLGTLKYMRGVIMGTSGLGDGLDDARLDPVWAAIEKAGQMIFLHPHYGLPKEVYGPRANEYGHVLPLALGFPLETTIAVSRMLLSGVWDRFTNLNVLLAHSGGTLPFLAGRIESCILHDGHLKSKGTRDNRRSVWDILKTNIYLDAVIYSEVGLGAAVAASGADRLLFGTDHPFFPPLEEDVEEWHSVNANYAAIAKAFDNDDQAKGVLGNNAVRILRLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWW1</accession>
    <name>A0A9P4PWW1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_478986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWW1"/>
    <dbReference type="OrthoDB" id="3776245at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="219" mass="24162" checksum="E7A61130A7EE2CC6" modified="2023-09-13" version="1">MPPFKTDLLLAFIEGQPITPEIARDVLNTCTTSQAAMHTISHAIAAYLDSPWYNLSGAASRKHIEDTNHELFRSLALLDYKVQHLYAETPVASSSEAGKGRDKAPAKGKAMSKHHSMPPPHWAVEVQKSAIKSRQFTTLLRSHSSDTPAAQIEKVYNDMLDVYELQRLNLVAVVGVMRGLLAAFDGGDGTVWKERMAEGPAVGWWLPDCLCDVKPLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXI1</accession>
    <name>A0A9P4PXI1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_403287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXI1"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2450704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="153" mass="17618" checksum="CF7E1A415462F30E" modified="2023-09-13" version="1">MAMATPTDQAPPAIPRLPSNPTPLSAPQEQQVRDLYYKNVRAKCATEIAAFATCATGRTFTMIYACRAQKLTMNTCMLQYQGPDELDKARAEWFALAGERRREKEDRAKLIEESKRKHKEWWGLDEDGKLQGKKLETKLERETRETAEREGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZ10</accession>
    <name>A0A9P4PZ10_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 12">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_15017</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5 12"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZ10"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.441.10:FF:000001">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000469">
        <property type="entry name" value="Mannose-6-phosphate isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="168"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2451918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="460" mass="50067" checksum="5BEECD4412CC692B" modified="2023-09-13" version="1">MVQVPLIRLQCGCNSYDWGKVGKSSAAARFAAATPSDGFSIQEEKPYAELWMGTHPSLPSKDLETQRSLLELVQDNQQLLGPTVAQKFGDKLPFLFKVLSIGKALSIQAHPNKKLAEQLHAKDPKNYPDDNHKPEMTIAVTPFDGLCGFRPLAEISHFLQHIPSLRKLIGEEEAKNFESTVKGKETSEDDSDVQANKKALQSVFTKLMNTDKAALESATDELLKAASSEGASFAGEGGPSNDGQELADLVVRLNDQFPKDIGLFVQFFLNYVKLEVGEAMFLRADDIHAYLSGDIIECMASSDNVVRAGFTPKFKDVDTLTSMLTYSYAPIDKQKMERPDYSGVKFNATAYSSNSSVIEYNPQEIDEFAVVRAALNKSGAKATFNDIDGPSIVLATKGKGTISVGNKSEKIEEGSVFFVGSTATLVIESETDADDGGEGLVVFKAYCDPEDWNANGGQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5K9</accession>
    <name>A0A9P4U5K9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_373959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5K9"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="128" mass="14119" checksum="CABFAF4E52407D87" modified="2023-09-13" version="1" fragment="single">RYLSHTVQTRVLNPAFLPMLLRTLRATLFPRNGLAPARQSPSEEEAKAIKGRCAATLLGLLPTTVASAFFANKNQADHLRKVEALLDCLDDTYLNKHLIFAIVELMVLRLVPELGDGGVQALLEERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5X8</accession>
    <name>A0A9P4U5X8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_373687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5X8"/>
    <dbReference type="OrthoDB" id="20473at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="273" mass="28985" checksum="2DC292B98B11A66F" modified="2023-09-13" version="1">MPALLVDTSTPSTSPSSSSTQRRSQSRSPNRPPVSPITPTVAAAQLARPEPPDARPRVAPPQPPPAATFIQPPPSVPISESENPDAIALRSAISLLQLQREKSKRDLKALEELKAAAVSDPHAFVRSLQEQRKEAAAKPTDVLTPTLSDIAEAAASEGAENTHGESGTARKDSAAVEGSLRDATKFPAVPQPQNIVRCPPVNWAKYHIVGEPLDKLHEEQKRYPGSSDPPRTQSGARAPPHRVAAPYSPFTDGIGGPPAAQPWRGPKKSKSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U698</accession>
    <name>A0A9P4U698_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_505459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U698"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="90"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="230" mass="25027" checksum="E6F02513DF31C3F8" modified="2023-09-13" version="1">MPPSNNVHMAPLEDADIPETFRIMSLSFGSDAPFINAYFPAHTTPTGQSQGSERLLAWKNSAPNSQFLKAVASSKNGGDVIIGIGIWTYMTEKPPQTLEEAEGEEEVRKYWPEEGDREWMRALWREYVKPRTGAVVGAEGSGVYVLELLAVHPEYRRLGAGAALVNAGLKAAEKKGVGAVIESTDAGRPLYEKCGLICEIENMVFNVGEEFGGKETPKLCFMVKGTTAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6J6</accession>
    <name>A0A9P4U6J6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_437265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6J6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="157" mass="17404" checksum="87582ADC30A8798A" modified="2023-09-13" version="1">MNTPMHESRAEQKTVSYDLSAVKLQGIVHTRIQFETFCKRIEGVSQSVAVISTSGPSSQTTIRRRASHFGSTRQAAVRAHNAPRAAFLVCHLWIPMFQWSNLSPISCSRKPPEALEAFSVKAPPTLPVAGTTRRPDKITPRHCISRLQCTPVIELVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6M7</accession>
    <name>A0A9P4U6M7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_394657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6M7"/>
    <dbReference type="OrthoDB" id="5336357at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="220" mass="24491" checksum="9EE404FD6ED96116" modified="2023-09-13" version="1">MGFKRKRSVDESPVSVSSFAGFATPDAQSPTPLPNGYSGMMNLDAPTSRGTGWDFSNLGRIKSGDWGLRTRKRFRDNRPDEHIIHETTINKLFSAQRTQPHAEPILSDTLPAQQEPVVQKPQKSTLHAFWNIPAPLVQPPIAQMQPPREADAPRCEDCDTLLEKDANDMDVDMDIDGPFERCSLACSDCGRNVCGQCAVVTNARHCLQCATSARNPKRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6Q5</accession>
    <name>A0A9P4U6Q5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_448147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6Q5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="223" mass="24812" checksum="79ED506250E145D5" modified="2023-09-13" version="1">MITTSNAALPALMMKVTTRNPGTAVNTNLQRIFALENSLPSPNFHLLFLPIFDQTRKATRQSRQASVLPPLLLCASRVQIVASPCLFNFHTPTLETILGSFSISANGSARIMQRQDEHEKQDCVKAKTLFEEIHDMQVKQTSGSDLTATTQHATSYLATRLSSSYLSKVMVSQNGVMCIPLKYWTRELQVLAMQDVFLGPAMELMSPGLPSILFKYSKVSWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6T4</accession>
    <name>A0A9P4U6T4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_457348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6T4"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="218"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2440479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="409" mass="43955" checksum="89C2D6D7DED441B9" modified="2023-09-13" version="1">MTDTESTSRSLIKHESTHQDGGRQAWLTIFGSFLVYYSSFGLLNSFGFFQNYYQDNYLSTVPPSTIAFIGTLQLALMNFLSAGPYLFSGLGTPAALLALSFCPRGGLWQIFLTQGLLLGVTAGFGVQPACTVVAQHFEKRRARAMSLVSTGGALGGVCFPLMFTQLQPLLGFPWTMRIAAIKVLACYSVALLISKDRPSGAKIRLGSLLDFHGFGDAKYTVLALGGCFVNFGLWVPGFHIKSYAIKLYPTQSIGKSLISLMSGSSVPGMIVGGLLGDRFGRLNIIVPMTFFSGFLCLSVWLLASSFPVLALFASLFGFTSGAVISLLPSVVSQIVPDDKVGARIGAFYSIISIATLTGAPIGTMVMGKDPTTREDYRGLIAFSGSAMLVGSLVLFAARILHSRDLRERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7B8</accession>
    <name>A0A9P4U7B8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_525963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7B8"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="102" mass="10600" checksum="4ACED48498278C8C" modified="2023-09-13" version="1">MSEAKSSPINTLTTFLALYLTTLFSLDTWTAARNSPYRAPSATSFYRPAGAPSEYQASMHGQGRRGPGGGSGGRREGRLPATLDTRAPLKAGSTAACGACAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7C3</accession>
    <name>A0A9P4U7C3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_448940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7C3"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="7">
        <location>
            <begin position="235"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="446" mass="50947" checksum="ECF45B5727647E48" modified="2023-09-13" version="1">MPRHILEPLDADSATLDEIPSHIYPWLRAVVVLSFLSFISAVTLLSLLTYRLILWQRKAKRTNQFVILIFNLLIADIQQSLAFLLNIEWLRVGSVVVGTPICYTQGWLVSTGDLSSGVWCFAIGLHTFASVVFDYRLSKKSFFICIFGLWAFIYGISLVGVGMYGKSLYVRSGVWCWIHHDLQDLRLWLHYFWIFVFEFGNVFIYAIIYTILIIRIRTGHYTDEQARRVKEISLLMVVYPIVYVICTIPLASARMSAMGKHPPSYARLCLAACMITSNGWLDVLLYTLTRRIMIFSDEPPSDDNGIDNFVAFWNEKPRRFGGTWAISGGDTEHPMPHRRGRGFGSLSLSLDNDSENDLVGAGSREIKLIKTTQVYSEPAQPEDYEEIEEMARQMRPRTPAGRWSEDSGRVKDIELAHLPSTKSLRTLRSLHSNRSRLSERSKTQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7C8</accession>
    <name>A0A9P4U7C8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_504398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7C8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="297" mass="32332" checksum="89A63AF8C6A700B7" modified="2023-09-13" version="1">MGPQLDIPRVSDKDMRRIRGIFYPTPDDEGFFSIDSFPEVLDLTGDSPIDSQSGSCNMNNVPEESPIQTIPRPDEANRVSDSITAEQVTRSSPMIDDSLYSDAETISDAPRTRDTIESSPMRRISRPRGANDSSPAGTVARATASSPISVPSLCSNTDTIPSSQTADMDSDTQVDQAMRSDEPDIQPSSQRSETPSGKSRQIPLFAIPGWAIRNKMQSLDQRKKNFEKSLNPLPPLPNGEKRKRGRPRINAPKPTPTPLPNGERRKPGRPRKNAVRVATASSSASVPASTVEPTITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7E3</accession>
    <name>A0A9P4U7E3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7E3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="96" mass="10295" checksum="C29075275A591419" modified="2023-09-13" version="1">MGLVIHRVSPPPVMMFALSCFTISTVLIITCPISTRSSPSRAVPTFRGDSHYELESIARDPRGALGWGLAYIAPGGEPFDKEEKTLSLVSCGGDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7R4</accession>
    <name>A0A9P4U7R4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7R4"/>
    <dbReference type="OrthoDB" id="3794181at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="338" mass="38042" checksum="BC2D8C6E916EAEB9" modified="2023-09-13" version="1">MTRHCSHRASVDQAKNRHHEERYDRRHDHYEPTRPARRWPSGGDYRFSSSSCGSSSSRRSSDCFSRRESASGGFLARRSIPISRSNSVSSPSSDRSSYTTQRSDWEAEMNSYFDALKGDVSFTQDLDPIVNNPDVRHDREARGSLHRSELVANQFDVTLKHVRDLLQHMLRKYNTVTCYSVGLLKPGDIIYYIEPFVLGFDQDIEGESASVLGGSRFQAAVQAKGRFGIVTRTIGRRTLKVAPMYTFNGDGLASKPLSIHDEYIELGRPGQFTWGWTKPKISPVIEKEFCLMKPGSAVHLITTKVTLTSQVLMAGSITPSSLEWLRSAIILAEESADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U824</accession>
    <name>A0A9P4U824_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_110314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U824"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="243" mass="25978" checksum="5AC26CF5E64424C1" modified="2023-09-13" version="1">MDMVARRARKVHSKPPLAPQASSADRCAGRQGIESQAELWRVWSHVQQQLMHGTGPGPGTVCLVSCVLWVKIRRRRDGQAQCVDRDTRPRPVTQRFHGDTWCPRAAPVGPASLPASLPACLPACLPACLPASQRSAHSFVAEAFGLVSPSERSLTRNCAMCRDSPPPPAKTAPPGAMRSGQWAGTVFFDAMPSLSGSVSEYLPVARCSIHNCTMGVHSSAMCAIWLAVAASVPARPLAHGPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8F6</accession>
    <name>A0A9P4U8F6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_91181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8F6"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2441170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="519" mass="58597" checksum="5DA253EC87C0E0E6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8Q3</accession>
    <name>A0A9P4U8Q3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_367736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8Q3"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="117"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="704" mass="78965" checksum="AD125EAB46E4E083" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA89</accession>
    <name>A0A9P4UA89_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_365421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA89"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF5">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040193896" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="32"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="335" mass="36707" checksum="68745655DED2EAED" modified="2023-09-13" version="1">MKLSALALVALLQRSQAALRFGCGTVTIQRLDPVVEPGNTPSAHLHQVVGGNAFGPNMTGDIGNQGTCTTCTFSEDFSNYWTAVLFFKHTNGSYKRVKIMENDALPAGINGGMTIYYTQKDFNSNGNQKITAFPPGFRMTVGHPTQGKDGMTKHKGLRFTCLDNKSTRFPEIDDFPKKPCKGGIMTEHHFPACWDGKNLDSPDHQAHMYDTQPTGFVAGAACPSSHPVRVPQVAYETLWDTAEFKDMWPKDGSNPFVFSYGGQDGHAYGTHADYMFGWKGDALQRAMDSSCMFNACENGKPLKSQSVSQMNACKAKEIVNENHDGWLKALPGVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAA8</accession>
    <name>A0A9P4UAA8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_496827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAA8"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2442058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="497" mass="54538" checksum="C310C038514E88A6" modified="2023-09-13" version="1">MAPPIPRANCGNEGEVDIIPGTELMKNADNVHLVHAHNSAESIVLIPQPTNSINGPLNWSPWWKFIVTFNQGFFVLSSIIPAFSISPLTQLLMDKWHKSLTEIALLTGTLVITLGYFNFIIIPCSEIFGRRITLLVCAVLNLIACVWSATATSYGSFLGARILTGTGAAANESIMNVVVADMYFLHERGRYIGTYFWCYFVGALLGPIISGAIAERGLNLLLLVFFCPETRRLHEYKSTLTPAEILRKAEPSPIWVLQPIDGAALKGVIRHVFLPLHILFFPIVFWASMSMGAAANALLGINLLQSPALSAPPYNFNPAQVGYANFALVAGGVIGLVTAGPWSDWMSARATMRNNGVREPEMRLVSLIPFIIAAIIGLVVFGVGIQEKWPWPTVVIVGFGFVGLQVVTISTITITYAIDCYKPVTGEIMVIATVCKNTFGFGMTYYMNDWATKSGYVQPVMLLMAMAVGITLFGMVVFIFFGKTFRRWTKDSNIHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAD1</accession>
    <name>A0A9P4UAD1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_474243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAD1"/>
    <dbReference type="OrthoDB" id="3140657at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="494" mass="57702" checksum="CFD2401B56618A54" modified="2023-09-13" version="1">MDPFSLMSLPIELINKIVFHIPQRSDLAALRLTSQTLNTISTPYYFSTVPLYPDWDEDSVSGGLPFPNSIEYDVRYFANILDSDNLKKLVRKVVIYLCNPDCDHHPHDCLYEGWMPKPEMSEEWIQLYERLSELPKLESISLVFDRHGGGFEMDDDMILHDYHFRSAELAQLLHMLKTRIKDLSVRHIQLDRESYDQDHGSIIASTLEGLRALRLSFVHEQQRGESGTVYKVTDCHEEWASFPSGWLEPAKNLRHLTLYSDLPTGWFPKVDLCSVHFAQLESLALGQFVFSDDRHFKWIVDHSATLQELYFDHCSILYQSGASQERNRWLDDEGYPKINLDDSVHGYSSLPGNGEEHILTLESYTIRWSDAFALFSRSLTSLRTFHFGTSSQWQFRTPNRRDDASAGHPIMPWEGERDLKNELFKERYLVYNDWDEDYNVHWEGSYEDVLDKKFWTDEELARFEKYPQCTDKDEGALKELLGKLGVTWHGRHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB65</accession>
    <name>A0A9P4UB65_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB65"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="228" mass="25069" checksum="2C4A024468FA989D" modified="2023-09-13" version="1">MSKVAVNYGSRLTRLASRRAATERQPQDWCFVAEKYLQQREASGLASGCSVRWAKTWVGLGQRRVDGGRNCCRNDSNRTPAHQHTSSSAHPSLAGDGSGLTTEQKDEQMARGTNAFGPPTDKAPATLYPAIAIATSQHPASNQPATSHATSLCATPRRLPRRRQRRNVAKLANEHADQSVTHRRIVHWADQRHHLSNGRRHQLMSPKRQLRNMLGASSSTGLAGHDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBA4</accession>
    <name>A0A9P4UBA4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBA4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="167" mass="19281" checksum="6797EDA476719331" modified="2023-09-13" version="1">MDYTRESTDPIEEPGLHVKPDEASNRHEVSSPQSEHSATRGSSDFAEEQDPAEEIDNAFDGSEIVNTIHRFTTTSSRRPTYETEGDMHMCTVYRTQDDDIVNGLCDTFKQSMRGDDEQRQLFEKAVQILHFTIALRRRYSYDKIEFITWKATTGKTSQHYLSSRKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBI5</accession>
    <name>A0A9P4UBI5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_432320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBI5"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2444260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="276" mass="29546" checksum="A555F96F3E72F411" modified="2023-09-13" version="1">MAGFDFSNHNRNAALHAQGVPLPKATSTGTTIVGCLFDGGVVIAADTRATSGPIVADKNCEKLHYIAPQIWCAGAGTAADTEFTTAIISSNLELHALSTGRKPRVVTCMTLLKQHLFRYQGHIGAYLVVAGVDPTGAHLFTVHAHGSTDKLPYVTMGSGSLAAMSVFETQWKRNLSREDAVKLCSDAIQAGIWNDLGSGSNVDVAVITGEKTTLMRNHLTPNTRGTKERNYKFARGTTAVLNEKIIKKEAISKYVTVHELQDDSVTATAETMDVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC72</accession>
    <name>A0A9P4UC72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_44722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC72"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="84" mass="9680" checksum="2A6BD214A4FB5617" modified="2023-09-13" version="1">MTWLPWLHLRYNLSNTTSVLASTWRIVHATTFLQHDRNGAFVRSLIPFVYHSFPFANIPFSLVRQSSTSRKVRTPSSCECALVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC92</accession>
    <name>A0A9P4UC92_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC92"/>
    <dbReference type="OrthoDB" id="3439627at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="81" mass="7903" checksum="899A5ACE16038A4E" modified="2023-09-13" version="1">MPRNGDGSSDNGPIDAGEIVHGASGDTTLKHTQNVAPLPEGEKGAAIEGLNASGGGSAGTSQGAHANDSNKPPVVDQVTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCK6</accession>
    <name>A0A9P4UCK6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_485371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCK6"/>
    <dbReference type="OrthoDB" id="5538558at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="119" mass="13483" checksum="3DDC863A974F4727" modified="2023-09-13" version="1">MESYDEYLNEDEYNDMIHAKSVIPVLIVAYREDDTQPTRNGGTTSLLFLKQQAIVAEVKGSVTYMDIKTGRPVDIRTLGGGWPKVFEGFTKKAEHAKMLNQKWDSDRPKNGKKMATSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCL1</accession>
    <name>A0A9P4UCL1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_292331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCL1"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF124">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="346" mass="39061" checksum="752DE20E21B2A47A" modified="2023-09-13" version="1">MVVHGTLTLVVAFTLTSLSTVVVALRFYARYFLVGKLGPPDWVMLAALIATWGTPVVNYYQLIYMDYSSTIDSNGNLIVEEYKRVASGSLLTMWIFRLTYIINHLLIKTSILLFYNYVTSASRAYYWTVRIMLGFVILSGLVMALVSIFICNPPQLSWDGEMFYQEIVANYRPTQCINPSVLWLTQAAYNLATDCIVWLLPVPFFLNLRTLPVRKRVELVAIFSVGIVAISASAVRLSITIRWLSGFDELGLQWLNILIWSQVEQHSGIIAASMPFLRPIFRKMMPRSTTPEFKLVPNVSPLGQPMPPRPPIIPSPVATFGSDDSFRPPPTPLSPIKPEMEMFHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCM1</accession>
    <name>A0A9P4UCM1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit CNL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CNO-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_355481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLOC1S4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCM1"/>
    <dbReference type="OrthoDB" id="5424991at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034455">
        <property type="entry name" value="CNL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="143" mass="16102" checksum="9218B0276EC92BBF" modified="2023-09-13" version="1">MSTSIPDNQLGLSQSEVQLLRQHQQIALSQQGSSSSRAASHASSQGRLLLDPSSLQALSAHFDRLMGSIQQRWHYLNQQTQTATTLQSTRAGAAIHNADAEIARFRALLREIDELQVEFDKVRRIGEIVKGFRARVQHLERRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDI2</accession>
    <name>A0A9P4UDI2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rab GTPase SrgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_514431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDI2"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2445192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="206" mass="22621" checksum="7025B046A06CFFE8" modified="2023-09-13" version="1">MAGTRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWFSNVEQHATEGVNKILIGNKCDWEEKRAVSTERGQALADELGIPFLEVSAKSNINVDQAFYSLAADIKKRLIDSARTEPSANKVDVGADAGGAGGGMGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDQ7</accession>
    <name>A0A9P4UDQ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_410592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDQ7"/>
    <dbReference type="OrthoDB" id="1288932at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="104"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2446405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="592" mass="62936" checksum="9EF78E6FABD6D75A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEA5</accession>
    <name>A0A9P4UEA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_442383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEA5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040430124" evidence="1">
        <location>
            <begin position="21"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="242" mass="26335" checksum="D547999E15BAF77C" modified="2023-09-13" version="1">MQFLTTAFTAFVVLAAAVSATKVDDNPLLARDDSIHHDSFPAYHTTSTSVFDRAGRCDERCRKYRCCYPWGACYCGAEAFAEFEQFDTQSGNIANTSSTCTHTSAPTPRPRPPSPSPCDPRCIKYHCCNSFGGCNCLAEVLDELERAEREGIALSIEAATRNIHPADIDLGSAANANYKCPGKPCGPPAGRCCWEGRHDRGRWCICPKALFPALDQQNEDAAGMDSARVSNMDYTAAAMDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGC2</accession>
    <name>A0A9P4UGC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_427618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGC2"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040181015" evidence="7">
        <location>
            <begin position="18"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="342"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="576" mass="63434" checksum="109F5AB97F70AADD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGG7</accession>
    <name>A0A9P4UGG7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytosine deaminase protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_351245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGG7"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052349">
        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="453" mass="50061" checksum="6B0994674778A70C" modified="2023-09-13" version="1">MLPPPRPCLSGHLSRVAAVRLPGKPSSSLWDVSIKEGRISSIDQHDASNSRVHNEDAEAVRNGTLDGSNRLLAPSLCHAHVHLDKCFLLQDPKYSDLQIESGDFQEAMELTGKAKARFDQDDLLRRGRTLIEESISSGVTAMRAFVEVDGGVQFKCLLAGLKLKAEYRDRCDIQLCAFAQLPLFSGEDGGEEVRKLMNIAATMELIDVLGSTPYVEEDQTKQEANVHWISSLALASGKHLDLHLDYFLEEDTQPLIWTALDIVKGYDWIGNQGKRITLGHCTRLTRFNDEDWMALRQSIGNLPVSFVGLPTSDLFMMRTRENLRGTLPIVEMIQRHGLDAAIAINNVGNAFTPHGNCDPLSIASLGVGIYQAGTKQDTEVLYEAVSNRAKAAIGCESTSLGLAIGEPADFVLFNRMSDWRCRKSISEVVYDAGPIRATIRRGRWTGKAKQSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGJ1</accession>
    <name>A0A9P4UGJ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_209939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGJ1"/>
    <dbReference type="OrthoDB" id="6135709at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="163" mass="19143" checksum="99FBDF130FD65112" modified="2023-09-13" version="1">MRARARPAPSWLSRRRRPHERSLGERPLDERPLDERPLDERPLDERPLDERPWWRPLAGPASWPAHGLSPVRPFRPRRQAWPVRRQAYRGLPRSVATRPPTRRFGSRQRVPNRSALVERPPDAIAVHPRARSSCLLRLLCIRLQHIMGQYLVRYVPFGMASEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHE0</accession>
    <name>A0A9P4UHE0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_479099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHE0"/>
    <dbReference type="OrthoDB" id="3692424at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="189" mass="19989" checksum="A66AB59F997D8C44" modified="2023-09-13" version="1">MLHRNPPHPAPNVRGEDETELQHLINIIEGKSSPFSTNNSNTPTALSWQVSPVPNKHFTVLLGRHPKPPTPSSAYIAAVYSMSKGGAKALEIGPEMGVSRKEALRRLLEVVEGEVGRGVLRDGRKKGEAVVGMAERPMVGGSGAAGIRGEGVGELRGRGDGGGAGARMRGREDMEQRDGGARREGGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHN9</accession>
    <name>A0A9P4UHN9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_350166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHN9"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="51" mass="5646" checksum="D5438693F5E95482" modified="2023-09-13" version="1">MTPDPDAIAECVLATFHHLPDKRKPRPESDGAREWVPLAGIVLADKGTPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIN2</accession>
    <name>A0A9P4UIN2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TrkH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_348820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIN2"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2450818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="684" mass="76450" checksum="53C2C164B1E306E0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIS6</accession>
    <name>A0A9P4UIS6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_17376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIS6"/>
    <dbReference type="OrthoDB" id="10357107at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="140" mass="15665" checksum="F77CCE741F4E9F5F" modified="2023-09-13" version="1">MAKLRKPNPNQAPPDTQTDMRMEDYTQQPTQHDDSFAPGESSRGRSTSFTEPERRLEPLRSHPPRPLTPFPTARSGEGDSAGSSNDVSKGKSSDKKELKQFPRDFNPAMFAGVCWCCGSTLVRRDLGEECVECWADQIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ26</accession>
    <name>A0A9P4UJ26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_1767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ26"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="299" mass="34689" checksum="5040385C4BAAD358" modified="2023-09-13" version="1">MKQMGYRPRGDRTMDLVSPSSLLWFSVDKSATRRSSLLNSEEITHPTWSWTGWRGAITYASLKFGRNASSYTESLRWSQSYKPAGIDWFHFLEEGNNIRHESEAFCAQPYCSQLVNLPWGHHRFKFKQYLDLRHLSLYRFCTSVCTTSNFHYYSWKSYVHRDSTPHIDVTLLGIFNRDGKRCGVLFNPPPFNPPLPSMGTNVQNYSLITISMKKQYSWLEDISTSDYNTKDEQEDTVNGCGCWLNVMLVKKSEQYEELVERVAVGQMHPRAWVEANPTVVIAHRPSMHYAKHAGLVLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJV3</accession>
    <name>A0A9P4UJV3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_478745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJV3"/>
    <dbReference type="OrthoDB" id="3770142at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040497546" evidence="2">
        <location>
            <begin position="22"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="224" mass="24802" checksum="6F5225072DD4A7CA" modified="2023-09-13" version="1">MQLHTAIYLSILPALLPGTLANFDVYADHYRGWSNTFRQPPGFRIFGRTPSDACKYVNNKTYIRWPARPDVSDEKFGIRCSGPGCTYDAANPAAITTFEMHFANTPAYHWTLYADNQGYAPPSTNARGLWMMPAEVGTRAPGYCFPYPGDEYDCERSRPEGPGGETFVVGSRGRRLFRCVTYNGEVESDDINGLRLQGGDMYYPYPDDDGEKSAGEGGVALGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJY9</accession>
    <name>A0A9P4UJY9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_438788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJY9"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2452183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="519" mass="58019" checksum="5BCC5AABA5901CD1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P528</accession>
    <name>A0A9P4P528_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHH phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_437790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P528"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.20:FF:000008">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF20">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040229153" evidence="5">
        <location>
            <begin position="19"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="DDH" evidence="6">
        <location>
            <begin position="70"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA2" evidence="7">
        <location>
            <begin position="279"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2437397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="453" mass="50721" checksum="9503282F153DB154" modified="2023-09-13" version="1">MKTLRLLPSALLASLTAASRAPFQQVLDAASGKAAPMRDDIGVGHFSEWSRATKKQFLIDWQAGKQSEWVFVMGNEAGDLDSMTSALTWAYHLEHSTQNTSNPTKAIALLQTQTDALDLRPENKLALKNSKMTSGHDDLLTMDELPEDPETLALKLRGIVLVDHASPLRKWEAAKILSIFDHHVDKGTAPDASPRIFEKVASCTSLVARQMFTEFYKLPEEYHLPHELLELILSAISIDSGGLASATATDLDASKRVFERSQWADRDLHEQMEAVDSWLSDAKKDLDDLSVRDLLRRDWKGDLVDTPSPRTPTVSLGFASIPYSLDEQIEKTGFGELFHWFAVHAAWTASINTDIDICLNKYKIKTKDGKKKKIREIVLTVRDDVRIDKVQADALFKAVRKALEGEESLGLKEWHRAGELASRQMVWTHESGAGRKVIRPIVEEAVRTWDMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P659</accession>
    <name>A0A9P4P659_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_476921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P659"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="241" mass="25996" checksum="91A289AD2982E2B6" modified="2023-09-13" version="1">MFRRRSNAESPWDHRVGLSSDKGDKPGTERPATLNKRLRDSLCSRQCNCSWLHSWLHSWLHRRPHGSRIVFLALACREGNYRGVPTITASRTSRRNLTPGHSATPLHRTSRGTTQGISESSPLPRLHAPGCHSHSPGRAATCINTESPPTRFPSPASDEREPPASQLTPSPAARAARVLTDNRPQAFDSVDGTLKVAVLSRQAGMPPAPATVAIAGLGCVAAVLPTRPVILTPSPAPAKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6C7</accession>
    <name>A0A9P4P6C7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_492027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6C7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="160" mass="18267" checksum="FDB06E4CD39C005E" modified="2023-09-13" version="1">MAAVQDLRCRRVTYKPGDGTRVRKLTKVLLRLCRHQIHDDCGNDNTVASIPHAADEGLRQVLGDFRTELFERFDISYARGDKKDLIFSQASLTLREFCKNHGSISKELHDFWDEKSSIYSAGLASYALWWTRTGSLNQPHPYPRPATTSRTVQRADRTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7E5</accession>
    <name>A0A9P4P7E5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_420989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7E5"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="322"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="566" mass="63379" checksum="FAD6ECCFA4C6FAF1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7F5</accession>
    <name>A0A9P4P7F5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat-containing protein-like protein mip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_371405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000278">
        <property type="entry name" value="WD repeat-containing protein mip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="148"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="884"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="935"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2438722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1398" mass="157480" checksum="1037712098E50AFE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7V4</accession>
    <name>A0A9P4P7V4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_525520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7V4"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040542919" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="552" mass="61702" checksum="8155CCF319D51D24" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7Z7</accession>
    <name>A0A9P4P7Z7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P171DRAFT_448968</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7Z7"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040126755" description="Probable beta-glucosidase G" evidence="19">
        <location>
            <begin position="18"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="734"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2438927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="820" mass="87958" checksum="AD92418E9DF7DF68" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8G4</accession>
    <name>A0A9P4P8G4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Biotin carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P171DRAFT_491302</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="56"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="208"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="16">
        <location>
            <begin position="691"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1514"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="20">
        <location>
            <begin position="1860"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2438648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2281" mass="254331" checksum="35CCFC702E7AEFED" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8T3</accession>
    <name>A0A9P4P8T3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_475958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8T3"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="529" mass="57624" checksum="B819A1406BB3F4F4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8Y9</accession>
    <name>A0A9P4P8Y9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_122386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8Y9"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="321" mass="36363" checksum="E3E0E6D3C3C39AA0" modified="2023-09-13" version="1">MPATRNAPVRIDINNTQVAAIVHIACGFQISEFAPIIHSWDMRMVTFGKYLMWYRISSIFYNIAIVLIKVAMLIQVLRIFVPRGSQSKTYYVFHGLIWMNLLYYVIIVFLMIFNCQPIEKAWKPSLPGQCVDISIIAMSTAVVNLVGDLSILFLTQKVIWNLMLVERCQRLKLSLVFMAGIVPCGFAVMCLYYNDKQMHFTDFTRDSMYMSIACYGEITSGMFVLFLPVVPKFFAHLKTASGFSLLSNKRTLLSEEVGHGASRGRVEPRKKSMFHISYTQKESEEKLAINVTSTVSVRHEMAGGGGIEMVRAGMSELLDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9F4</accession>
    <name>A0A9P4P9F4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_489504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9F4"/>
    <dbReference type="OrthoDB" id="10487354at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="99" mass="10633" checksum="51B322F97C41AEEF" modified="2023-09-13" version="1">MTVQFGGFVAIVHLETADAYHHEHAERDSDAPMSASEQACCVTLIGSTAGGTFSSPLRPRANKLEQLLPHAPFEFLGERDTFDLHKAAANAPLARSTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAA5</accession>
    <name>A0A9P4PAA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Purine-cytosine permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_435941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAA5"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="510" mass="55470" checksum="BF817243FB8B6BD5" modified="2023-09-13" version="1">MDPSVAPDEKTSRMVLAPNQGLPTNNTDVHNETLAGRWKSLEALMAEYSVESRGIQRVEPDERHNLSQLGYSQIAMLWISINLAANNITLGMLGPAVFELGFLDSCLCAVFGMLVGCLPVAYIATFGPRSGNRTMIFSRYIMGWWPSKIVVVLNLIVFLGYSLIDCVVAGQILSGVSANTMSVVVGIIIVAIITWVITTFGYQVFHYYERYAWLSQLIVLSMLAGAAGPNFNISSASLVSGDTLAANRLSFFGLALAAAITYSGGAADLFVYYPEHTAGWKIFTVTMLGLTSSFTFAFILGIGLASGMSTNPAWEASYGISQGALIVEGFKPLGSFGSFCGVLVALGLVQNLIVPTYACGIDAQVLGRWAAVVPRVVWNTVGIIIYTVCALAGRGHLAEIFTNFLALMGYWVSIWVAIILEEHFIFRRSTGFNWHIWDDRKKLPIGIAALIAFVVGWVGAILCMAQVWYIGPIAKLVGDYGADMGNYVGFAWAAVIYPPIRFWELKKFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAV9</accession>
    <name>A0A9P4PAV9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_489617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAV9"/>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28845" checksum="68FA9BB9E3307305" modified="2023-09-13" version="1">MYAFLGDKPHLDEAIVHAGYGLGYGNVCSQGQWLHPIADNTGLDTSNVTDSLSSASDNNASLDADVVPARRGRGRPRVNTPRDESAVEKRRAQVREAQRAYQKRKDSATASERRRCDDVLQVLSDLSMDVEALLQAAADAGVTKEEGELADHIRRLWSTYDTAINSPCLGPELRLLQVKNERRQAAHQNAGHPSTERNTHVQQPSHQRDSMDLDLGPVNDQTLITPFSATQMSYPSSGPRSIYQVCRERQAEFHRTRNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBD4</accession>
    <name>A0A9P4PBD4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_393664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBD4"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="433" mass="48413" checksum="79741A8738273432" modified="2023-09-13" version="1">MASNSYLIVGAGVFGVSTAYTLIRKYPNASVTLVDRDAYDADSRVAASWDWNKVIRADYDDIIYCRLALEAQDIFEQDPLYQPFFHKTGIYWMCRTDYATQVVDNYRKLGRKAELEAMSVKDARKLYGGLFEDADYSDVKDVLVNRTSGWANAGDALKAVTKKSIELGVKYVVAETESLTFNGGRCTGIRTKRGDTLRADKVILSTGAFTAKLLEQAAKASGKPGISAGGRIIAGGITTGMTQLDEESYKRFKDMPVAVQSFTATVGPFVGSLPPTRDRELKWWGSKIFKNTQSILGKRISAPPPEPDYAQWRVAPPLRQDIDAANALFYGKNGASWKMEKHRICWDAFTSSSDFIISPHAGAEGLYVATCGSFHGYKFFPVLGKYVVQMLEGELEEDLKEKWAWDRERPDERLNPEFPRWEMREILGAQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBJ1</accession>
    <name>A0A9P4PBJ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trm112p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_367272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBJ1"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="142" mass="15640" checksum="C1EA618CB9433AAC" modified="2023-09-13" version="1">MKLLTLNFLTCAIKTCKSAPSSFPLHPRDASLEVIETDLNLPFLKNILPRLMWDELRVITSELGLPDLPPTPPTREDLVVAAEDAAVEGEESEEEASQTAKDLHRVLLETTVKEGKLVCGNCGHEYKVLEGVPNFLLPGHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBN8</accession>
    <name>A0A9P4PBN8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynamin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_391640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBN8"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="50"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="621"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="799"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2442045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="823" mass="92008" checksum="15CBA440D58CE937" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC14</accession>
    <name>A0A9P4PC14_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC14"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="153" mass="17216" checksum="28216558A5A5B0C8" modified="2023-09-13" version="1" fragment="single">MSNQRIEGIKSRASHNVGQLFACMRPRSPHVLTDSTTLPRPAWQEVISFGELGSDVWRQNLQFNADRQYVGPAQPTSSITDQDRRNASGIDPEPLLTRLGTDTDIQMKDVLSFQIGEDVLMGGDGEPPQSRRPPPSYTTDDQADEHCRKRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC16</accession>
    <name>A0A9P4PC16_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_92148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC16"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="273" mass="30828" checksum="835BCB2D376EC96B" modified="2023-09-13" version="1">MALKRELSPSPDVPTNIYRSEKIQHETSAFVGAFSPTLPAKALQTLPEFRTASHKMAAWRTRSKQKSLTPASKVLYDLGHDDDGEKWAGSRLQHVLNDTGTEGVVVVARWYGGQNIGPIRFTHIETCAKQAIWSWKVADDAAKKEHAVKKQKVEEETTRKELEENLRERDLNIFVLRKLLADKKAKLEDTEPAPPTPSKSLQDYSKMTMEALNRVDKARDATIAFVLKQIDKVDEELKLAKALDETTEDDWKDAEEAFAKREAAMSETKHGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC94</accession>
    <name>A0A9P4PC94_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_487899</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC94"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="10">
        <location>
            <begin position="119"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2441436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="239" mass="26305" checksum="72FE360FEB8EB484" modified="2023-09-13" version="1">MALPLPPGLTPPEIAFMCEMELVTIIPRQRLEGLELLGGPLKPLNPPQRASIPLWLALLLKRQRRANIIPPPWLSPHSLAAILKFETEDSPVAFSPPPRLPPLPPSTTVPLSSPFLPSSTADAAADALPYHWLELGSMLLEAAPDDFDDADEVRKLLRGLREARMAKLRQSVEVLDAGGGFKMNGVGGMELGEARSFITGVVDGLRKIGKSREEARKERDRENGYSPSQDYDDDEMDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCR2</accession>
    <name>A0A9P4PCR2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_74487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCR2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="240" mass="26859" checksum="81D251CC231C19C5" modified="2023-09-13" version="1">MRRLGRDNSALHIEQHSELQRNRQQNLQDPFPGRISSSDPTQQPLTCLMYGWITNHISQRKRTATRPRKTSADTLPPWLSLHGNIRNTICLRWPLPQNMSKDLGAAFSGDKRANSHSQHRLHRSLHHAPIPIPILTTRRSHFTDCAAPRPEKQHPIPSHPISSHLTDGPPNQVPTHRPSRTQSQSTGRTPPPPACPPANPPANPPVYPFTYSAYPSPPTSYPQVPQHKPNARTCSDISAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCV7</accession>
    <name>A0A9P4PCV7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCV7"/>
    <dbReference type="OrthoDB" id="3537171at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37048">
        <property type="entry name" value="QUESTIONABLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37048:SF2">
        <property type="entry name" value="QUESTIONABLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="359" mass="41029" checksum="4A4F1FB19FF37888" modified="2023-09-13" version="1">MANYNYSYSQSYDAYGAYTHPHAEYGNTSPTRTHARAPASRGISSSQKVPTRGVDEADVVTGRVFWLPPQEDLPPRAVRRAHGKGAVEEGIYNHPIVVVSRPAEEPQVVHFHIVTSFQGKRLHEIYSKNNEFHASRRSWYLPISPSPPHPDASSKKMQKRFPTLELQHGASLRWDSYVNIRHVYKIDWTLLRPYANPDTPCVQSFRFDRESCDKMLAKTKILTNYEPEVQHQVHYEAYQERPPYRQSGRTMTSPLPLRIPDTPVRYDQAANPRGQDYSPYSPQAPSLNSPKSYSDEGSVVGSEYSGLSPILQSDFGVPQTEFKMDTPVPKKRPPDGKTRKVCLVMVFVLKWPWRMLCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD83</accession>
    <name>A0A9P4PD83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_51303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD83"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000006">
        <property type="entry name" value="NOL1/NOP2/Sun domain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="139"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="246"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2442884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="583" mass="64532" checksum="387091D053B6BAD5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PER1</accession>
    <name>A0A9P4PER1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_362133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PER1"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="438"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="733"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="755"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="811" mass="92442" checksum="8892C5CF7763A641" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF49</accession>
    <name>A0A9P4PF49_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF49"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="241" mass="24954" checksum="B256B3D8F7F26928" modified="2023-09-13" version="1">MKIEPQSPICPSPEPSIPDPIPPGAPPTPPATPPRKHDVVPTQAGPKPPPPPSPPPPSPSKTTPGGLPPPPPPPPSTPPPPIRPKLNDLGSGGYTPLLPKRHVINDLGIPYPPPPPPPAPKRHPMSSHGPCPKPRPTPPAPPPSPVKANRHVGLVPGVKEVGRGGYTPLPPPPPPPPPPPPPPPPKRRAINDLGRGGYTPLPPPPPPPPKRHADIVELSGTPNLTPVSEGIDLGMARWMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFE9</accession>
    <name>A0A9P4PFE9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RINT-1 family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_494162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFE9"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="835" mass="92481" checksum="DDACCDA42E641A4E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFG7</accession>
    <name>A0A9P4PFG7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_364470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2441971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFG7"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040544403" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="552" mass="61006" checksum="C61C65CFF1B3987E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFZ8</accession>
    <name>A0A9P4PFZ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_392028</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFZ8"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2442289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="342" mass="38349" checksum="76FDE1E00A6B6B17" modified="2023-09-13" version="1">MDHHCPWTANCVSHTTFPHFIRFLFYASGGLSWLEYLLWIRISYLWETRNMPAYLGPNPFLVAHLFAATVINSITVFALGVLFIRNVWCLVVNTTTIEGWEIERHKTLLRRARHFGGMLQSPDGTKVPIRKQEFPYDVGMWQNIKQGMGTGNPLSWFNPLATTPSLNSGLTFPTNGFEDAALSWPPPDPDRSYRRPPPSKNATPFTFAESTLSPQESLAAFRERQVADAVRRRKPFVQRVEAQLARDRDGDGLGDGYGDGYGDGYGNGLSEGDMSGDEDVQEGGRMGDGDEEGEEAWRNSEGERLKDFGVDEEVEFYDEQEDDDVPLGELLARKQAASGTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG66</accession>
    <name>A0A9P4PG66_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_414550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG66"/>
    <dbReference type="OrthoDB" id="10006218at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="347" mass="39676" checksum="597C8B8A5633BC06" modified="2023-09-13" version="1">MTFLRSPQGRAVATIVVLIFFIAVLHNNAEEESYLHSFPLPQRASGRRFAGLRERMALSESAWKKSVQLRGRMAESHPSNPQIPLFPAQSLDQFGKYPYTLWDFFPPTWTCPHDVQRIGRLGDGGKWVCGMSVYESIPIPTTWMRGVPTGGQEGVVIYSFGINGESSFEAEMFERIPSARIWGYDFSVDAWGKQIASKYHDRAFFKKVGVGKTDEPAKSPPFYTLQTLMAQNNHTYMDILKIDVEGSEYVSFDSVMDYFTSAWRGNGDAVLPIGQIMIEIHVGDDQKGIDFKRFRKWWERLESMGMRPTWMEVNLMAMTIPDHKTDPRCTEYVLVNARDGNNVLWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGH3</accession>
    <name>A0A9P4PGH3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_69293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGH3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040494546" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16445" checksum="15ED6A281C8472D8" modified="2023-09-13" version="1">MKRMWIRGAKLLKVSAASLALAHACFCGARLRHHFDSMLRVAACSLALFNSDMDCFVCTSASSLCGAVIASSKPSRCGHGTGRQASSSRISGPQNACLRPMMWPCMESAWRLRLVCICTCPSVPMVRIEGAWPGSPARWTAHWFLSHCDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGL1</accession>
    <name>A0A9P4PGL1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGL1"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="140" mass="16203" checksum="8A843475CB2F13CA" modified="2023-09-13" version="1">MRFHCTQVRWVFYLTFLWIFSWPALFFATKRYAVVKAEWPWSTTDSQGIKEYSSISEEQWFEKWHVGIRRLVLDRYQCEASEEVLRGVMARDEDPGSIRTGHEGVDSTVNLLTQGFQVARALSNGSNLGRGIQGGWGYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH23</accession>
    <name>A0A9P4PH23_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH23"/>
    <dbReference type="OrthoDB" id="5363415at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018858">
        <property type="entry name" value="DUF2458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10454">
        <property type="entry name" value="DUF2458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="260" mass="29158" checksum="DD3F5530040FB20D" modified="2023-09-13" version="1">MADNSLPPELNLEQILATLANLPQAAIPPVPAEQQFHAPGQFGAQLNSVPASHYPSQTGIPYSQEQSQDPRLNARPQTTLSSRQAPPQRRTATPTIDPATITEWKHGLRCVNKIATQSPTFVPAIQKLIADQARNVKDWESGRQRLIDEQAVKRENEKTHLAVLSLPGMGEKISPLRTDEVEKEELEMYAKKVYRAAQRMVELQSKEMKGLGVPFFGLRSEFLRSDGSDEGEEEQKKVTKGELLELQRKMLNHLMELYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI34</accession>
    <name>A0A9P4PI34_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI34"/>
    <dbReference type="OrthoDB" id="3684005at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="299" mass="32792" checksum="E1D5B9BB8C744BCB" modified="2023-09-13" version="1">MTDPDAPLHPQFIHPKCATYHLPPPGTPLTEYGLVHGGAIITMAETLSRSDAESNWVLSRLLQSTYIDPFIRIDRNDAIVIPTATHMERLTQIHKRYKHVCSLSHNSALEMLWVPGFEPSYEGNPAIEDLDGLEVPGGLRKAVFDGADMYERSGKRRGVVFGEVRDRGGWGRRLWDLPRGEMEGTPEEIPSEWVTQVTCQKDMESGRLVLKNVRVGPKVSAAGLMRVNVEGVEIRFVEVWSAENGEGVSAEKVKGASAEDVEGASARAVEGANAVDYAGDPEKMIKQEEGSTVVGDSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIU6</accession>
    <name>A0A9P4PIU6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_443723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIU6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="365" mass="40449" checksum="CB3EBB6AD073759E" modified="2023-09-13" version="1">MEAKQSQLIIASRRLIQIFQVSASKSSNLPLSLNRTTRQPKTQQGNAWLCLVVPPHRTQSEVPSTSGIKHEQEILQGKTGRLSIRAYGKSPRCKQAHSGLESQREEKHSSRARVAFGEKWRKSSLDQAIGYEGDPSALVVQLTLGYSDVKRKAGEANGEAVERPRFALLHHCTLYAKLSIAKMTQMSMHPNKQRCRWSGAFLVIPRERLLFRGDTKGARVMKRAAAASAQTQGRSARRVGFVYHRPPGEQGRRVCGSIEAVRFGSNLLLRGRWSSRLPSHGDGRAPAAWSGRLSSAPVNLTVSMTLSFTRGAKLHRDDTVAVRAWSGDRTVLCGPRFNFGSGCQLGLYKERPEDRTPEPRSRGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIV9</accession>
    <name>A0A9P4PIV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_285392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIV9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="89" mass="10316" checksum="EC4262A71C23C0DD" modified="2023-09-13" version="1">MIRTRRCLPCIIRRRRCARRGGRRDPSDERQTIICQARVTPKGPQRVRARHSARACTLPLWAAMISHDQPRASTGGVNVVPHKRRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJI1</accession>
    <name>A0A9P4PJI1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_454746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJI1"/>
    <dbReference type="OrthoDB" id="425936at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957">
        <property type="entry name" value="BLR7070 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040190851" description="Phytase-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="2">
        <location>
            <begin position="139"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="507" mass="55001" checksum="47E63B508A5D6DA3" modified="2023-09-13" version="1">MMNSLSLGLFAVLQFGSVAASPISYAAQSVNETNCNGKKFVYEELAGWGTLPGDARDKFGDSIGGIGSAIALDKKSWKKKSGKKEAYEGILWGLPDRGWNTQGTQNTQSRLHKFSVSFDIVTATKDRPASPNFHLKYLDTLLLTGPDGKPTTVTTYMFTPMLTIADTGDGFGGAGPGGKRIAIDTEGLVIGDGGSFWISDEYGPYIYQFDKRGRMINAIRPNDALIPVRNGTESFNAASPPIYNQDFVITPEDPDSGRGNNQGLEGLTASPDGKYLYSLLQSAAIQEGGSKSKNRRYARLLKYRLKGKKPEYDAEYVVPLPILPTEKVAGQSEIHFISDNQFLVLARDSGSGHGQDSSESIYRNADVFDISKATNIKDTKNDATGGAIASPKGVLNPDVVPAQYCPWLSFNNNDQLNRFGVHNGGEQDATLLNEKWESLALLPVDGKFKTKGDGDEYYLISISDNDFITQNGYINSGKNKFADVSGFNLDTQVLVFKASATRVSGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK64</accession>
    <name>A0A9P4PK64_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_282723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK64"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="49"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2444793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="372" mass="40307" checksum="76CD025857B79914" modified="2023-09-13" version="1">MADSVSANMNQNSVSDDVRVLGYDPLIPPQLLSSEIPITKASEDTVLRGRRECIRIITQQDDRLLVMVGPCSIHDPETALEYCDRLKALADKLSGELLIIMRAYLEKPRTTVGWKGLINDPDINESYQINKGLRVSRKMYCDLTSKGMPIASEMLDTISPQFLADLISLGAIGARTTESQLHRELASGLSFPIGFKNGTDGGLTVAVDAIGAAAAKHHFMGVTKQGLAAITRTAGNEHCFVILRGGTKGTNFDKDNIKAAREALRKKNLPEVLMVDCSHGNSSKDHRNQPKVAKVISEQIRDGETGIVAVMIESNINEGNQKVPAEGPSALKKGVSITDACIDWDTTVNTLEDLAAAVKERRSKKGTTNGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLA5</accession>
    <name>A0A9P4PLA5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="7">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_256472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="7"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLA5"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2446281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="322" mass="34785" checksum="C80661DBADC024E8" modified="2023-09-13" version="1">MSETMDTLAAPNAYARASETAAYVRSKLPEALQKPKVAIVCGSGLGGLVDTIDAEPKVELAYSTIPNFPRSTVQGHAGNFVFGLIGPQKTPVALLVGRAHFYEGHTMDLVTFATRVCKLLGVGTMIVTNAAGGLNENYEVGDIVCLNDHLNLAGLVGIHPLRGPNIDEFGVRFPPLSDAYDLDLRRRTHKAWKKLGLDQQKRKLHEGVYAFVGGPSYETRAECRMLRILGADVVGMSTVPEIIVARHAGVRVLAFSLVTNKAVLDAGSRGNDEAIQTLSKSELNEHLNQGKANHQEVLDAGREAAKDMQALVKQILSDLHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLY5</accession>
    <name>A0A9P4PLY5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_485302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLY5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="64144" checksum="00D5D28FEE8EED0C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM72</accession>
    <name>A0A9P4PM72_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_354392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM72"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="7">
        <location>
            <begin position="785"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2447684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="853" mass="93676" checksum="10559BF3B53AAB92" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNH7</accession>
    <name>A0A9P4PNH7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_519540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNH7"/>
    <dbReference type="OrthoDB" id="3784745at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="362" mass="38933" checksum="AAC38EB6365AED0E" modified="2023-09-13" version="1">MSLPVNLIDFPDPNSHRADTSPAALPQKPQARPSNTNISLRLHTGFKPPKGLRHKSNYNPPWPFSGVPSPQTMHHHILNRKLDKKYFSITLMQPPATPWSPLPSHQNMETRTCFHTGSRIHKLDCGHTVAVPHNAEPCAANCKPPMSTISSTSSALPAPYAAPINLLRASTIRVVHAHMDALAAAADPLANAKLAAHANILSAVWEAQDKALAPPRDLISGDFSCALCGTPGLRDTRAAAVVGGPPYHCVVVGWDEGDVAVIRELEKGVQPRAPPRGASFGSGFGRGPPLKRLGAADDRGHRRSGVTVGVGVGVRESAGEMRRRRRDGWQAAVRRKEKEGVIGRLREEVLMEELGGMGLGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ22</accession>
    <name>A0A9P4PQ22_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_453150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ22"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="44"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="252" mass="28763" checksum="42B632BC3E50EAAF" modified="2023-09-13" version="1">MVVFSRSPFKTTVHDDRFTFIALDLSNDPDSLIKDMRTLCNDFKELNIANEKLFSNFSDALLAVAPRLENCTLQTGGRHSKVHLGPVNSPACEKDPKRESPIGNFYYPQEDYLICCQKGQRWTWNVVRPEAIIGHNSKPNGMNSALTYLLYLLVCKELGSEARMPTNQLYWEGYDELSDSKLIADLTIWASTSYKAGKEALNAADKQEVWNQIYEEILCPEANSTWESGTWAFQDWVFQRTWSATLSINKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ40</accession>
    <name>A0A9P4PQ40_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_480345</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ40"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="32"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2449245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="271" mass="29077" checksum="5541DE808F5EE56E" modified="2023-09-13" version="1">MPRNTLSFPSTSATQIEPYLPEPRDLARPLYPHVTLTYATSLDANLSLSPGVQTALSGPQSKAMTHFLRSKHAAILIGAGTAIADDPSLNCRIEGVGGYGGPGLNGQPRPVVLDAKGRWKVNEDNKVIKLAKEGRGLGPWVIGAQDTPPEDGRYKALTEAGGLYITLPTDSRGRFDWGDIFNILGTNGLFSVMVEGGGVVINELLSPRYIGLVDSVIVTIAPVWLGKDGVQVCPEERRNEGGVKMSVGRLKDVRWLPLGEDVVLCGRPGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQB1</accession>
    <name>A0A9P4PQB1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_517069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQB1"/>
    <dbReference type="OrthoDB" id="10535160at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="272" mass="28686" checksum="7FA519596AE7F4BE" modified="2023-09-13" version="1">MASDQGWFNGWAVAASVGHVAAEQPKWSCWLLVVLEGFGVASTHPHEPTTRNGGPADSGLEEVTCRRPPVLPCSRAPVLHAACCGRWCCRGSARTAGRPPSVCFVLGRACLPSHARVEQSAQTGSIAISAAPVGGFWQQSHGEDHGPGNTGVAVSSPEAAKNNGRLKVFYASPLPLCIVSISRGLQATPVLPCNTQPYVHTAALPAPLAAKQPLCLPLCPSAPRHDEPPTPTCPARRPPPSADAIVGPIEELHGQQRRGLVRDNWLRMKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQF3</accession>
    <name>A0A9P4PQF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQF3"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="224" mass="24702" checksum="E5D9B43767D00DC3" modified="2023-09-13" version="1">MSNNGKITIYIDCVSPYSWFAFTNIVNYRPLLNAHGVEVEILPFFLGAARDGAGNPWTPTPQWKAAFSAQDTDLTGNLLGLKVVTPEVFPISSLFPVRIATFVKFNYPAENFDATFEAFASGYWSKGINISKPEGVLKALDGIFPAQEIREIMKKALTPENKKRVIDITSGSGAFGAPWIVGTNKSGEARSWFGNDRWDQVFWHLGVPFERVKILPLGGGNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQK4</accession>
    <name>A0A9P4PQK4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_247349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQK4"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040173598" description="CREG-like beta-barrel domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="40"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="253" mass="28367" checksum="5D422E7C6015DD92" modified="2023-09-13" version="1">MRLETALLPLISLASASAISSWHDKAAHETYHDGATYRIPTVHESAVLARRILDIEKIGTLSTVFPEGGHTTENRPSDVGGSPIGLPDYFANCEPDTGNPTILELPIATSFKNVQAGSNISLSLRWHAPYKHWYSVASVPRFNLVGYLEEFTDEEVKSENIAACFVKKHPDAAAWLPGNRIHVSKWVRFVVQEMYWIGGFGDRAYIGWIPLEEWQSVTRDEIEKARLPGEGSPWSSWMAWFGLADNKQEMLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQK7</accession>
    <name>A0A9P4PQK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">F-box/WD repeat-containing protein pof1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_428428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQK7"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="401"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="522"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="562"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="644"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="671"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="706" mass="77935" checksum="21CB8EC9F9CFB2E7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQU9</accession>
    <name>A0A9P4PQU9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_451787</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQU9"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000069">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="207"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="71"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="305"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="321"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2449619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="496" mass="55241" checksum="84D467D8C8B82C5D" modified="2023-09-13" version="1">MRGMPNAAPDPRRAYTRPAFAPKPAIDIKHIRQNPGLYEQNCIDRNYAAHSKSSWRIIELHEQWLALQQNARHLRERNNQIRGQLAKAKSHSAGEGEGQSRESLIDEAKALKAEIGAVEAKEALLQEEIDNLAQDLPNLSSTDTPVGTEPQLLEYINDHPEPEPSRSDRVWRSHVHIGSELGILDFAASAQTSGWGWYFLVGDAAMLEQALVQYALTVARKRGWKAVAPPSLVYSHVASACGFQPRDQNGEQQVYAIEQAEKDQAKPQLVLAGTAEIPLAGMKANQTFEDVELPLKTVGVSRCYRAEAGARGIDTKGLYRVHEFTKVEMFAWTLPDTNEQEHFAADTPSNSITIFEEMLSIQKEILLSLGLHCRVLEMPTTDLGASATRKIDIEAFFPSRREKDEGWGEVTSTSMCTDYQSRRLHTRVRLGKTGGKLEFPYTLNGTALAVPRVLAAILENSWNEHDYSVTIPEVLQPFMGGQDKIQGHKIHGTGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR92</accession>
    <name>A0A9P4PR92_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_480888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR92"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF147">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="41"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2449829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="381" mass="43787" checksum="8FF266571953BD3A" modified="2023-09-13" version="1">MWLRPRASDGADSITNYVNPEKELNAGLWSLFTGATLFLVLRLYCKITRRHGLWYDDYILVLAWSMLLLTDAMISHQYATGYVPTNGSKWDDRMHILINISSCTNVLGQTWSKTAFGVTLLKLTNRYQQWIIWFCIITMNLWMVVKVVFQWAKLCDEKSYDVSYRLDFCIDKTFRSDFKEAGNIYNIIMDFVFAFFPWWITWKIDMRKSEKIGLCVAMSLGVIVAVVAAIRVAWKDEGNKRDPYYYQRNGISNVWYSSEVAGTILVQCIPVLRPFLREVQRSFTSKRLASEGGTDHERSWAWTVSRKQDSTISSYPHMDLKALEGTGGTNGLNFGFNETKISSNSGLELETIQELGGEEKGGVTRGRSVRTVTSKRSEHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR94</accession>
    <name>A0A9P4PR94_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperonin Cpn10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_429167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR94"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="103" mass="11194" checksum="1FE6062C002FB021" modified="2023-09-13" version="1">MSAIKSIRSIAPLLDRILVQRIKPEAKTATGIFLPDSAVKELNEAKVLAVGPGAYDREGKRVAPSVQPGDKVLIPQFGGSPLKVGEEEYSLFRDHELLAKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRB7</accession>
    <name>A0A9P4PRB7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_380108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRB7"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040413770" evidence="2">
        <location>
            <begin position="25"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="716" mass="77895" checksum="36EC22564D531BA7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSA1</accession>
    <name>A0A9P4PSA1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_427695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSA1"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45397" checksum="94771176EB23B883" modified="2023-09-13" version="1">MAVRVPSWTLRSPQHPLSRRYRSTAREQFREQFRRSPISFPFALISIFALAGWGAYYIPWYYRNVIQKPYHNFPEPVARKLRRAIFYSRGQHLDIREANKYFRQALQLATEIGMDPFSDEIMGVKYAIAALFEEQGYYAMACDVLEIMRTDTQRWIDEFSDKHITDGNRSRVKKNMVQINLKLGQLYDCPYVNEPKDAEKRLVDAVEGALGEQQRRETEGVKQGEGDWMTNDELGATLEALGQHYEHNDSHYLALPLFLRALELCPPTSCHGVVLMNNISTCLAQQTPPPASLILSSPSSFPNTPSPPRTALVDQARQWADKALQRAGSIADQDEECNVGCAVATHNLGEFYEMEGKTQDARRKYKDAEQLAKKIGFSEGQANAKAGIARLKELEKAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSW2</accession>
    <name>A0A9P4PSW2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_428431</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSW2"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2448334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="428" mass="47232" checksum="43AD15E4B296F5D7" modified="2023-09-13" version="1">MAMRSPLSHAVKRATWKSPATPVLSPCTQRWKRGNATVAPPPVTQSSAGSKGPTAMVFMNMGGPSTTDEVHGFLNNLFSDADLIPLGRLQNYIGPYIARRRTPKIQKQYAEIGGGSPIRKWSEYQAAEMCKILDQTSPETAPHKPYVAFRYANPLTEQMYQQLLADGFGGGKGGRAVAFTQYPQYSCSTTGSSLNELWKWRQRLEGKRAGGEVDAEGSIKWSVIDRWPTHSGLVEAFAQNIEKTLQEYPPERRDDVVLLYSAHSLPMTVVNRGDPYPQEVAATVHAVNQRLGMKYKYRLVWQSQVGPQPWLGAQTSDTVKNLMKKGNTDLILIPIAFTSDHIETLYELDKEVIGEDAEGHEGVKRVESLNGNPIFIQGLADIAKAHLHSGVACSKQMTLRCPGCVSERCLGSKEFFAGQNQLLEPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTC8</accession>
    <name>A0A9P4PTC8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_441212</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTC8"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2448923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="250" mass="28321" checksum="8AE48FE4A90881DB" modified="2023-09-13" version="1">MHSTLVRVQNVFGFFTTVAFTVAAVIALSTFIHPQTPQATVGLRNVQVVRGRPHYYSYKKEEYAHIKFDLDTDLSTLFNWNTKQVFLYLKAVYPSTKAGEPDSEAIIWDAILPGAAAPWHQNHYIHPTPKGTKKPKNSKNSQAKSHMPAGIIKLDSQRPKYQITDISGKLQNRTDARLELGWNVQPWVGALLWENWNDYGMWKGLQGGKSELFDFPAIGAKSPKKEKLDVEKGKEGHRLMAGQEQPRKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTL1</accession>
    <name>A0A9P4PTL1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_441309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTL1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12371" checksum="C39007496954A4D6" modified="2023-09-13" version="1">MPGAAEKQYIGHTMTIKDAIRSYRAPGSLQMSIAVVRYPKLSTDSKSQLKVCTILDELQLPSKLHYKELTETNGDDYLEMKPNIQLPAITDPKSGLTLWEESDDILPALHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU29</accession>
    <name>A0A9P4PU29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_426653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU29"/>
    <dbReference type="OrthoDB" id="5411518at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290:SF6">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41534" checksum="815DCEAF7E87D1D9" modified="2023-09-13" version="1">MALRNFSPNALLENWTDEKYNPNHNGKSFEECIRTAFNIPKTDDYVYRAQGETTLAITQRAIGGKRVHGMHDWYHDENRNLNDPPHPSPDEISAYISLFSPSVSLPKALNAFKATSKPNTLRAHISNHLQGRFHNTTTGLLPSKKERAHTNPYFSHWAYSCDELEWAGPWPNTVHTKIAHHILPVFYHHFGCVVPTYAALHVIAKLAQPAKPSKEDVRPILDIGSGNGYWSFMLRNFPLVENMKTLDVRPIDNGLSEYRVSWVGDTIREDGVAYLKNNDGGKGCVLLLVYPQATGNFTGPVLKAFKGDSIVVAGTQNGNGFTAFQDEVVDEWVERELKEFELTLRMPLPSFAGKDEALFVFQRRKVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUH0</accession>
    <name>A0A9P4PUH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_426093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUH0"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="91"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="398" mass="44469" checksum="18E095CA934A75BA" modified="2023-09-13" version="1">MAPGLVETAIEVTQVATKDLKATVKPTGNIHNYVPGRTTVKKHDETYKYEDLRPRFPDITWPALTPVEYNDKGLLGDANFKNLISAATDVFDYNPKVGTEIHGVDLANLTDLQKNDLARLIATRGVVFFRDQKNFGVDEQRALGKYFGELHSHATTAMPRREGLEDVHVVYTGEDSPDLRALFTPTFLWHSDVTYEEQPPSYTSLKVLSGPPRGGGGDTLWSSQYAAYDMLSPYMQKYLESLTAIHSADLQAQGTRELGRTVRREPVTTAHPLVRTHPVTGWKSLFFNPGFVTKIVGVPKTESDAIIALLNEIVATSPEVQVRFQWNEGDVAFWDNRVCNHSASYGFAPHRRHAVRVCCRAERPYLDPESKSQEDDLSARYGIPKANKDGSGIVNYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUJ3</accession>
    <name>A0A9P4PUJ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_439761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUJ3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="358" mass="34582" checksum="328CEEAF5BC6AD7F" modified="2023-09-13" version="1">MLCPSQRSAVPRHPQIIKHFAPGTSPHLELRPLSSIFFTRSMVHQHTKNDTHLILSQTGGVGEATPPSGSGTIFSPTPGEGTNPSGGTNPGGTNPSDATAPGSTPLDSTPLATGKGTGKGPSGAGEATPSPTLGNGGVSPDPTPPAQGTGAGEGTNASREPSSTPLSTSIEVLPSPGNGPDDGDDTGIDADDDDDVPTTSTSGGTNPNNGGEPGLTEATPSPTGSTAIQLPPGNGPSNAGETGIQVEDDADVSFNFPTPTSDGTPPNATPSAVGNINGNDPNNGGGPSVTPQGDGTPPEATQPAQGNDNGNGSSDGGETGTAPSGDVAPGSGTVPGGQQPPAQGPGKGTGLNNAVSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUT2</accession>
    <name>A0A9P4PUT2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_438440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUT2"/>
    <dbReference type="OrthoDB" id="3778887at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="252" mass="28845" checksum="F180CB0B5D87BF20" modified="2023-09-13" version="1">MTTQTVQVVEKIASIHRSIFWAYEENGLSYPIVSVKRAAQRNPGHKFEVYEPTGDYNTAPVAGKQACSADVPEAIKRGLMVWNECDFAVQTLFHSLQKQLSGSLPGTRVQWLSVDIAPIFIFREPDAGADDPVPAHSAFFITLPGDGGEFVVDFTIEQFGYGRERWFLPFEEYKAMTCDGSWYIYEYEDRGVDLQNAFTDEHLRSQRVMRELCDEVDWVVVQQMAESDCAAFMKMTYRGMHEQHRPKKRAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW88</accession>
    <name>A0A9P4PW88_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_351854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW88"/>
    <dbReference type="OrthoDB" id="5340195at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF3">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="642" mass="72020" checksum="1BD75D5A86F8CF59" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWR4</accession>
    <name>A0A9P4PWR4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWR4"/>
    <dbReference type="OrthoDB" id="2150942at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="322" mass="36695" checksum="70C6B47ABE6331D9" modified="2023-09-13" version="1">MATTAEIQRERRQHPPTPTMRQINPSKFYVQYQGHPIEDLQTFHDITLQQRPNKPIVWFAGDSSLDNKYWVPGSGPGGDSLDVEVPEIYNHTLQRATPKPDVAFWINHILRDKATCINTAVEASMLRERDKNLLPHDEFVRDHIGEDDVLIVSVGCNDIAMKPSFSTIWRMLALAWLTPRSSIDQGSAWSLRYFAHFFGTKIENYVKRLCSKTKPRAVIVCMIYYPLEAHYGQRGWGDKALKFLGYGRDPGKLQAAIRMMFEMGTKTVKVEGTDVIPCKLYEVLDGSNEEDYVERVEPSANGGRKMADMFKILIEGVLKKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXC4</accession>
    <name>A0A9P4PXC4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CT20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_480078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXC4"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="281" mass="30893" checksum="16F14BF5203C616E" modified="2023-09-13" version="1">MPPRKKAKASAASTPLADVQPKTPQDAGPTAEQEQLNDAWADEQETQLFKSMMKWKPTGIHKHFRIISIHADLRSHGFAADDTPHTRIPAIWSKVASLYDLRALDEREDAYTFSDDPDPLDPDEALTIPDFELPEDEFGAMVWERRFHGPDSEASSSPPTLATDDEKLLYVPDMGLLKDQPDGILSQLTESAAEATPASKRGKGTRPTKGAAKGAKTARGQAAKNTKAQSAVSDSAEEEEDEDEDEEESSSESEEDTAPSTRRTNRNKGKAQPAPKRTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZF0</accession>
    <name>A0A9P4PZF0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_468402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZF0"/>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="3">
        <location>
            <begin position="18"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2452013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="219" mass="25491" checksum="1A05E6B5A51E624D" modified="2023-09-13" version="1">MTTPTSATKAPPRDPLEQYLRSLEIRDRREKKHEKYINIITDYADKAAAKEKERLSAERDAPEPATPDIKSRSNWRYSRSSPVPSPADPAHITQLRADLASSNKIRSEKETELKAVEEERNKLKFKATTQARWIEELEKKTKTLERRVKDTTEELKGQRQLAEHAQDEMMVMQMEVNAKDKDLKKAEADVQMLTSRWMQEKGEDARRMNEAVEKAQKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZH0</accession>
    <name>A0A9P4PZH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_515683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZH0"/>
    <dbReference type="OrthoDB" id="4838853at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="281" mass="31303" checksum="9B814DB5E4C59C1E" modified="2023-09-13" version="1">MTVELPYTLHTRYASIATAWSVILTPPIFLNLSLFYGLWYGKPDLDRILVLTLPTAILGLFTALATLDRVWKLTQPTPLYRPLHAPRPALDIFQWGYFAVLAAISALITAALARNDADHDFQIRLLSLPTALLMSLVATLTLISLVLNVSGWRLPFRFGSVPAGNVLRPAVYYIVEDVVAVDGGGGVEYREAFCKRYESSAVFRRMMFELSVVWMLWFYVFAGVFAALVFRLPVAAVYAVGWAGPFPLVGGVAVWTVFYVRARLREEREGVVEGERAPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4H3</accession>
    <name>A0A9P4U4H3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_372888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4H3"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="65"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="271" mass="29949" checksum="DC8C41EAC330E3AB" modified="2023-09-13" version="1">MFGSLKKKLSRRGSNPPSQKSAEANTSTQGGYLAPSNNSPLTNPSSATRRPTTDDDPYAFLRNFDTVFLIDDSGSMAGGRWGQVEQALSVIAPICAERDEDGIDVYFLNNKKIWKHQRTAGHIIEIFQDAKPGGQTFTGKRLYEMLAPYLARYKKDPANTKPVNIIVITDGQAHDDVAGTIQDVAKKLDRWEAPPWQVGIQFFQIGNDPEARNMLKQLDDELAGSDDLRDIVDTVPFTSEGGAQLSATGIMKVVLGSVNRRLDRNSKELHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U555</accession>
    <name>A0A9P4U555_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_526928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U555"/>
    <dbReference type="OrthoDB" id="4395072at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="656" mass="73046" checksum="9ACB1D254A5CA7CB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U619</accession>
    <name>A0A9P4U619_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_436271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U619"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="41"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="492" mass="54940" checksum="0970DAB9997F61F5" modified="2023-09-13" version="1">MYYGMDTLEKRRTAPMGDRGTVVNIVSWLLTVVAICLLTARFTMRLSIKDKTRRFGLHDLFIVLAFLFSVGQTIAVSVESIQALGQHITELSPNQIMIFQKTEYASCILYIASMGCARISLCLLIKDILPGSVARFTALGFAAFTALWTVTGVLVAAFLCPSPNPWQRGNGKKRLEISSWVNYVGSTNIVVEILLIMIPLCVWNVRTSAGRRIYVSLLFVSRLSVVAAVSAQLHFFNARHTEDFTYESWRTVLCIQIAQNLSIITACLPSLHPFIVKMLAGSIKSEEILTCGEHSPLVSWLTGRRAFDSMSSQSSSMPIKQEKKEEYCAPLATYGLDRASTHLISPQSNRFPLNIATPRASPEPPKDVFMRSVEIPTSASRSASLRRKSTVRTVRNSIGIPEIPEIPKSLAEVGVLPLIDFDADSNTSDRRSKTSSQQSRRPPSDYVFSRSKVISVPDESFLRDQREEGQYYKKYYPPLPSPKTPRKPPRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6B3</accession>
    <name>A0A9P4U6B3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_173807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6B3"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF8">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_6G00670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="49415" checksum="6633AC5FC8CBFAA5" modified="2023-09-13" version="1">MAVSAAGITSNSNTPSSTPTTTLPSFVMESFSATPQFSFTVALSLLSTPSSISSSAPAQTFTVQVGNGDHKFKPDVIQAEVGDIVEFDFYPVNHSVIRAEYEHPCIPYEMTGRGKTGFWSGFHATDVVLDDPPKYTVRVNDTNPVFFYCSAPDSCTNQGMVGVINPNASTSLAHQRDLALQASYQLSPGEPFPFEAETPSSSTLPNGTALQTLDPAHAGAKLGAGAIAGISIAAVGVVVLGVLLAFFWGRLKSLKDEVNRKDSTVVRSTEPRNTWFLAGSPSTHTWPSPGAQTLTQNQPSPPYSATVQDRDMSMGIMGDVEAGSPMTSHAVPPAYYESPAQWSRNGAVGLGISGDTAAQTHMSRAASRRSVGGTFEQSPVTGAYTRTHEGSDAEGDAYKFAPPTMTSDMTSPVDPGLVGPSELQRANRTPEVREGYVDEKGRWVGRHVNREDPAEMADTSVAGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6F2</accession>
    <name>A0A9P4U6F2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beige protein homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_421473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in protein sorting and cell wall formation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="9">
        <location>
            <begin position="1832"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="8">
        <location>
            <begin position="2005"/>
            <end position="2297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="2430"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="959"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1152"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="967"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="979"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1152"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00054699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2440074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="2628" mass="295733" checksum="4439469FA884C307" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7A5</accession>
    <name>A0A9P4U7A5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_397234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7A5"/>
    <dbReference type="OrthoDB" id="5332384at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040491080" evidence="1">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="180" mass="19661" checksum="40142AABE4955206" modified="2023-09-13" version="1" fragment="single">MRSSVIAVLASLGLANAACSTVSKVTHTFYGYPDNDPPGPATAYDCGRNFKAGGTGTYTDPLTFASAQGEFKACEIIYDPYLRKYLRYEDYCQQCTDDWAASPKINHIDVWTGSPTVNGGQQQIQCENDLTPADRSQTIVRQPATNLPVDTFDTALYVKGASPACRVNKVFPNYNIGDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8B1</accession>
    <name>A0A9P4U8B1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_435466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8B1"/>
    <dbReference type="OrthoDB" id="3798666at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040393195" evidence="2">
        <location>
            <begin position="21"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="542" mass="58449" checksum="D9DFED756AA310E5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8L3</accession>
    <name>A0A9P4U8L3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_419620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8L3"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000008">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="969"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2441335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1119" mass="124386" checksum="D36D74A6BEE5738D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8R9</accession>
    <name>A0A9P4U8R9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_524146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8R9"/>
    <dbReference type="OrthoDB" id="3804322at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="273" mass="31203" checksum="68A0AE678799677D" modified="2023-09-13" version="1">MSQPARSPREQTLPHDTGGNINVNAWAKANLDQDIINGTSEDPKVQQELLQSDFVRFASQRNADCLFVFHTEGYEFPIYAPYVRMTAQKYAQYGAHNMHPNPPTLTIDLPYHAWMVQAAITFWKTHKLVVPADDHACFAEETTPHPHPRPEERPSLLRLARMVNLATYTHDIALRTTIYATLRARLLSSTYTPAELLDAIKFVWCERPVSWERYEVVRRILLTGLLRVREKVCGVLEGYFQHVVDESGGEGGAFMTAFNLGQVWWEESGMRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8T2</accession>
    <name>A0A9P4U8T2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_367496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8T2"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="340" mass="37678" checksum="C71A4C10E3D6FACF" modified="2023-09-13" version="1">MPSLPKRQLGKSGPDVSVLGFGAMGLSSSYGKVEANEARFAVLDRALELGSTFWDTSDVYADSEDLLKLWFERTGKRDQIFLATKFGVTIANGKPTMRSDPAYVRQACEKSLRRLGLDKIDLYYCHRVDKKTPIEETVAAMAELKKEGRIGAIGLSEVSAATIRRAEKVHHIDAVQLEYSPFTLDIESPEIGILETCRELGIAVVAYSPLGRGFLTGQIKSPEDFEEGDFRKHAPRYSKENFPKNLKLVQTLQDIASKKGCTAGQLSLAWLMAQGLDIIPIPGTKKIKYLEENIGTINVHLTDEEAKQMRAEIEKVEVAGDRYPPAFQSYSFGDTPELSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9U0</accession>
    <name>A0A9P4U9U0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_487582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9U0"/>
    <dbReference type="OrthoDB" id="5428055at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="64369" checksum="498240145D844C2F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9X3</accession>
    <name>A0A9P4U9X3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_523638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9X3"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="552" mass="62316" checksum="614374AD098A48CA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAL1</accession>
    <name>A0A9P4UAL1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_433478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAL1"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040414118" evidence="6">
        <location>
            <begin position="19"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="7">
        <location>
            <begin position="69"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="330" mass="35967" checksum="3DE01D045847481A" modified="2023-09-13" version="1">MKSRSLLALAHLTTTIHGLNFSLNPLRGIQQFPLSFYTNTEKIAGNMTRRAPVISISHGGGPMPLLGDPSQAALTHSMKTKVPKILKLGTADAPRAIVLVTAHWSEDVVGISSAEKHELYYDYYGFPDEAYKLKYNAPGSPEVAELVRRQLEEAGIKSKKDAKRGWDHGVFVPMTLIHPTATTPIVQLSVLASEDPAAHHAIGRALAPLRDQNIAIIGSGFASMHNLRAMFSGQSRTPAYKALNEEWSRAVTDAVNTQEVDAQKEKFAGWRAWKGSYDMHPRGGAEHFLPLVVCAGAGGAEKAKAYGDEMVGLTMWSYYWDGEGEDGAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAS3</accession>
    <name>A0A9P4UAS3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_432633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAS3"/>
    <dbReference type="OrthoDB" id="3800401at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="196" mass="21457" checksum="1F2E7FB284960017" modified="2023-09-13" version="1">METANARMVDVDEEIDEEIFASVMETVAASAKARTFEDAQRNGMLGVTVELDILGIGSVFTGHWQADGEYHVHESDLTTDLIREVGALLCFGDILPSRDEFLSPSKMHGLLALLNPCTTASSTDCCPVCQDDITELASAVVVMQCDHIFHAGCIEPWLLEYQQGCRGTCPLCREKLFVMPGHENCTELECKPDIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB69</accession>
    <name>A0A9P4UB69_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_444132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB69"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="305" mass="33140" checksum="410E51CC80581A44" modified="2023-09-13" version="1">MREHEILAESWSRRGGTEQLVGPAPVIHFTEIAPSKSFVCKSQELDEYINHTEQFYFSSALPHTPARTHTRTSTSTSTSTSTSTSTSTSTSTNTNTNTTTFTTITSTSTSSTSSNNNNSNSTTTSTTRTTTLDMFSRNMSDVAGALKSTQDPPSPAHDSAESLSELDKELHELATGELEGRIAELEAELEKVKAEKAVREAQIEGMTSIGSDNQLGMYRLVGEKLQLDAEVARLEAKLKKYLGKLKDAVGENQLLKEECARKDEALVAAQKEIAELRMQLAAAGVQSLSLQHGVREGVDDDVMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB95</accession>
    <name>A0A9P4UB95_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_432110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB95"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040463288" description="endo-1,3(4)-beta-glucanase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="31"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="475"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="551"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2444020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="634" mass="63961" checksum="1069938E485BC0D1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBU2</accession>
    <name>A0A9P4UBU2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_38111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBU2"/>
    <dbReference type="OrthoDB" id="3796810at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="327" mass="36340" checksum="2C8EBBC46BF8AC87" modified="2023-09-13" version="1">MGFWNTAKWTLTTALDHIEGRPTRKQYKLHPDSAYLGNKYYAKETPVPPNFTRPRTSGNPTSTSTSTSSTLPSLASSPQSLTGGDTEGMHIGLMQPHVHIGKKAVQTPMRLPEAKYTVLRQGDLVDDDKIDSTVGRDRDLYWVVKGAVVLMVKERSEAVTTPARKTREEGREEVMEEAVDGVNGGHKNLLRSPSVEGMLLFYSISAYVDIIANQSPDFFADIFDEGQYAPIDTLPPNPLAKVPGISQSLNPLDAIPWSELIIVFRRDTKELFVRKQDGKLYPVVWKVRAMHSRLQEVYAGSRAVNGVKFTSVEGEIDAEGYVNVEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC27</accession>
    <name>A0A9P4UC27_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC27"/>
    <dbReference type="OrthoDB" id="3789983at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="379" mass="41587" checksum="DA89E70CA8FDF6FE" modified="2023-09-13" version="1">MAEESQFYITSVAHGMVLARSPNGQPSGVVAQNRGDQDLPQKWVAEQGDAPNIIALRCLSNNEYLHANGGGNWATVGTGAKQWWKLDINNVTAPGACRLSPVEYPNVFLNHFQGIRVAKGQSMKVHMWQWEQPNQFCLTWYFLPADGSFGPNTSASGAASDSKKAADAKIEELEASKKTSDAKLKEFEDTKKASDAQLKELQDTKKASDAKLKDLQDTKNASDAKLQELEASKQEYAAKLQALEAGKAGSAAAIQDLQDKLARQSRDLDAQKAALQRNVDDQKAQDARRALKKAGKQDAKMQKKEEKALKKEDKPQKKPQKLQHANKLPPTPPASPPQEKATLPATTAPNKEVRNACKHVVLPPPRKIRRKVVGIVYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDE5</accession>
    <name>A0A9P4UDE5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_453605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDE5"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="99"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="309"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2446090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="545" mass="59517" checksum="6111DF0327EBD573" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDF6</accession>
    <name>A0A9P4UDF6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_410408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDF6"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF3">
        <property type="entry name" value="CUPIN 2 CONSERVED BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="186" mass="20499" checksum="B3B2EA94670AABC5" modified="2023-09-13" version="1">MSQKIAQESPLQSLNRFITTHDESTGKSVFSNAVLEQNPTQVVPGVVFRQGYVTKKFPVQLNGDEDLDAYQSFLKSPPGLVNSSGTVLRIVDLPPQSTSPMHRTVSLDYGIVLIGEVDLLLDSGEVRTMRPGDMAIQRGTMHAWVNKNPTEWARIAFVLQPSEPVVVGGKKLEEDYADMEGVKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDL5</accession>
    <name>A0A9P4UDL5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_442694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDL5"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF5">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="149" mass="16387" checksum="6136BBC9ABF6D45C" modified="2023-09-13" version="1">MAGTYTSHFGINIPYGIAHSAKRPAPQAVTRIDDEVIFLAELSKKGSFTEISANLSSIFAEKTLNTFAAQPKKVHVQTRVALQEAYKSVLHKEFSEDIKYVELLLPVQVGDFTDFSVSRDHVTCVDSGCENDNKISSPKQCTPCYATAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEG1</accession>
    <name>A0A9P4UEG1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_441176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEG1"/>
    <dbReference type="OrthoDB" id="10468716at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="960" mass="109336" checksum="56AD852A2C77B63C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEI0</accession>
    <name>A0A9P4UEI0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_352896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEI0"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="51"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="493" mass="55759" checksum="9A41D5032C24CCF4" modified="2023-09-13" version="1" fragment="single">DIQAWFADCVTHKDCKQPTETSLSRLVIQVNPSNDPYQVRLLEFTRLKGRYATLSYCWGAPSSHVLTSSTLKQYKRAIPWSYIPQTIKDAIQVTRAANLQYPWVDAFCIFQDDGKDKIHEITNMCDIYRKYYITIVAANADDASKGFLGHGLIDVETYTVPFRIETVQSWALTLQEQALSQRVLYFGNYTLQWRCGAGKISLARDTIRFSGYHLKRGGEDELQCAMLKPLPWSKDDAPRLWVRLIANYSPRKCTNAMDRLNALAGIAQAFSSSLGPAYYAGLWQVDPLQQHDWHRGTGGPTQVVRSQVYCAPSWSWASSRGDIETMYSREKWVSHVVKVECTPSSPELPYGAVTSGFIILSGRFAYGQLVRCHGGGGHPWTIMLEKKDGHVHSIYNAGEGSLKLRDKPMRVFLDGIGEMEPKRVLCFAMYAIYISGRVGGLVLEAAAQRTNTFRRVRQFDRISDVESKPYESWTDGEVAIIRASLLLAIRHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEJ0</accession>
    <name>A0A9P4UEJ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_429137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEJ0"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="182" mass="20489" checksum="C72DC646EE36F723" modified="2023-09-13" version="1">MHSSSSACSSPPSSTPQDQRWTVEVISPTTVNEVVTFINNARHDMFPTLHTQLSDDVARWVQSGTFLAARDATSKSLVATIGFVAYDHRFPSLHYRDNHTVEVVRLYVLPRYRRAGLGATLFEELKGRAEEQGVRRLYLHTHPFLPGAVGFWEKRGFGVVGVERDEVWKTTHMEMLVGSGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEJ1</accession>
    <name>A0A9P4UEJ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_461605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEJ1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="67"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="462" mass="50571" checksum="6D50214F37979D66" modified="2023-09-13" version="1">MRLQAISDVLNPISPLANLSLSVPHRVLVVGCAYGGLSAVVNLLDCDKGKARESYYPDAPDFKEKRSRNGVEITVLDERDGYFHSVGAPLAHTVPKHTVNMWKRFSHTNELRSQRNLNFKHGSLQRIDPDAKVAEWLDRNGKTQHQAYDYLIMATGLKRHWPAVPKSGSYEEYLRDSQTFISKIVGGDPKIPQEGRRVVVIGAGAVGIEFAGEIKTHYPGINVTLIHSRDQVLSSEPLPSDVKDKVKDILVEEGVDVVTGNRAAITELPNGEFEVKLANGTVLIADFVIDSTRKGEPTTDPLPEACLNKDKEVKVNLDLSFQDTIPNASSHFGVGDVVEWSGIKRAGSAMVMGQTAAQNIYAAILNSESRHASPDEQYKLLKLNKWEPVIGIAIGKQCLTWGSKAGMKYGVEVMEGYFGDDLGWAGNLKYVGLTDVEEEKEPAKPEAVKMGEVGVQEISAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UES7</accession>
    <name>A0A9P4UES7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_188371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UES7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="114" mass="12412" checksum="53B449E62D73C24B" modified="2023-09-13" version="1">MAPMSRAPSLCQLILRQSCMLTPNPLRTNPPSIPAINLARLQTPCPLLPGSNAGPASSHRSHLHPLPIASTRPPSSCRWMPPRLPRFVLSRQTPKGPLSLHARSTRCQHLPPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UES8</accession>
    <name>A0A9P4UES8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_429069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UES8"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2447830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="893" mass="101294" checksum="914552D6FAB07304" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFP5</accession>
    <name>A0A9P4UFP5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_230772</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFP5"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="195" mass="21323" checksum="3DA17F244C9A2687" modified="2023-09-13" version="1">MVKEHWDIRANMDTPPSSKVHVFSGPLQLATIRGIGSLSRGDRDERAGTARQLNSTSPGINRVWNQHMIFVALVCRELQSQRSLLRLFSSLHARSQALAVPLRTAGLARRGNDSPFPTVSTPIAARGRGSPCMRRARDGVPRRPVLPAGAPRIPVPDECNAVARRGRQTTEVPGKQLQRAPQGSHRVRARAPPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFV4</accession>
    <name>A0A9P4UFV4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_377488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFV4"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="476" mass="53976" checksum="AD8A8C11F281B9ED" modified="2023-09-13" version="1">MNLSLVDPFVLAQDCPEVITGRLRSGHSTSIRFSHRGDLLASGRHDGIVVVFDIETNGVARKLRGHTRQIQSLSWSTNDRFLLSAGQDWKCVLWDLKDGSRVRTVRFESAIFIAELHPKNHMIFAAALFEDQPVLVDMSAEVPVKHMLPTAPRRSQTEREKATEKQAAQDAKQTTTVTIFTPSADHILAGTNKGWLNIIDTRTHEVMYSYRVTNSLIVLIRMTHSGRDVVLNSSDRIIRTFLLPDLSDPNLDFDMLELKVQHKFQDLVQRLSWNHVTFSSAGDYVAATTYMNHHVYIWERGQGSLVKILEGTKEELSVLEWHPFRPFVAAIGVDSGRVWLWSILQPQRWSALAPDFVEVEENVEYIEKEDEFDIQPLEELHKRRLDQEDEEVDVLTIDPVKTNAQHEPGEFRMPVLLDIEASDSEDEIVAVGAGQFRRRSPGAGKEYMNDDEVGVSGDEVRRANGSTASGTKRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGL0</accession>
    <name>A0A9P4UGL0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P171DRAFT_404414</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGL0"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="20">
        <location>
            <begin position="334"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="55"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="193"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="486"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2449300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="519" mass="59520" checksum="24C4B1D07A75FB8A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHA9</accession>
    <name>A0A9P4UHA9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_376558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHA9"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2451999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="126" mass="13791" checksum="99C285624EA080E5" modified="2023-09-13" version="1">MSNDTSAAWPQADQALSTEILDLVQQATHFRQIRKGANESTKTLNRGIAEVIILAADTSPLAILLHLPLLCEDKNVPYVYVPSKMALGRACGVSRSVIACSITTNEASDLMQQIRSLKDKVERLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHC3</accession>
    <name>A0A9P4UHC3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CNDP dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_350773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHC3"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="217"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2450050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="476" mass="52717" checksum="726ED11AE4AE92A0" modified="2023-09-13" version="1">MSHLDPFFKQVDSLQDQFIERLREAVAIPSISSEDARRPDVVKMGHWLADQIKALGGTVELRELGKQPGREHLDLPPCLLGRYGDDPKKPNVLVYGHYDVQPAQLSDGWSTDPFTLSIDDKDRMYGRGATDDKGPVLGWLNAIEAHQKAGVELPVNLIMCFEGMEENGSEGLDETIRAEAKKFFKDADVVCISDNYWLGTEKPCLTYGVRGCNYYALEVSGPGQDLHSGVYGGLTHEPMTDLVRIMNSLVDPDGKILIEGIQDLVAPLTDTEAALYPPIAFTMDDLHQSLGSTVSIYDNKEDSLKAKMRYPSLSLHGIEGAFYTPGAKTVIPAKVIGKFSIRTVPNMEIDEVTQLVEKHVNAEFKKLKSKNTFKFHIVHCGKWWVEDPNHPNYTAAAKAVERVFGVKPDMTREGGSIPVTLTFQEELGKNVLLLPMGSSTDAAHSINEKLDKRNYIEGTKLLGAYLHYVAGELKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHN5</accession>
    <name>A0A9P4UHN5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_427651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHN5"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="121"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="261" mass="29081" checksum="B4CAEA4C4F85D16B" modified="2023-09-13" version="1">MAPKVKKAAPAPFPQGKAGTKKTAKNPLLEKRPKNFGIGQDIQPQRNLGRMVRWPAYVRLQRQKKILNLRLKVPPSIAQFQHVLDRNTATQAFKLLNKYRPETKAEKKERLTKEATAVSEGKKKEDVSKKPYTAKFGLNHVVGLIENKKASLVLIANDVDPIELVVFLPALCRKMGVPYAIVKGKARLGTVVHQKTAAVLALTEVRSEDKSELSKLSSAIQDGYLEKHKDTIRHWGGGIMGAKANARMDKRRKALESAIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJB6</accession>
    <name>A0A9P4UJB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_425694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJB6"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="44"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2451162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="562" mass="61238" checksum="41F1E1D230E00DCB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJX3</accession>
    <name>A0A9P4UJX3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_493257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJX3"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040487577" description="AA9 family lytic polysaccharide monooxygenase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2451777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="254" mass="27611" checksum="1262E26636AC4C37" modified="2023-09-13" version="1">MKLTIATIVAALSGTSLAHGGVTSYLIDNKNYTGYVWSDPYEGQHDLIQRSWDMNPLSDPASTNVTCNNKGLAVPGTFHAPVTAGSSIRATWVTPDGFGWPHTLGPLVAYLASCDGDCTTITDTSSLKWFKIAEDGLRPGYAVGEDDGWYQNDLWENRRTRYWNVTVPAGLKPGRYIVRHEIIMIGLDPVQLYPNCAHLEVSGEGESVPGDEFLVTFPGAYSLTDPGIAISGKALNDKTTKNYTVPGPKVWKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UK73</accession>
    <name>A0A9P4UK73_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_438690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UK73"/>
    <dbReference type="OrthoDB" id="2849579at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="72"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2452062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="411" mass="46237" checksum="8DC72EE33C1E6C01" modified="2023-09-13" version="1">MSSPQENGMNNTNSPTENTPLPALVPADDLAAPQDRTRTGGLPLREHFVDPANGLLLPLTDPRTEARPQDVCAICWEPMDNLSEAEVITSCGHIYHRGCLRRWFENRDAFYGTCPMDRARLFRTHLSERTLAAREQQRWMDVSFQGRVLIDGSVADRVRLGASSAQIFAELEHVQDRLGRLDAEEQRLNALLGELNRVSENRASRAEQTAGRTSASPFLNGRIGTEQIATASDSLFHGETPQVRLPRPRPFVRLSAPIGDVHNRRSGVEHGAFATPISSSFEDTTEASLGQTSEMDESPHRVVWDHDNLIRDRNRAIQDRNLVIEDLDRTIEDLDNAIRDRNRAFATGISNVPRAPRAPWVPHAPQAPRYTPAFPSHDELDFALTDEQLYEMEAIRRQAAEIERLYNEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P3Q3</accession>
    <name>A0A9P4P3Q3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_172102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P3Q3"/>
    <dbReference type="OrthoDB" id="5296889at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="344" mass="39035" checksum="64547321EBCEEEFF" modified="2023-09-13" version="1">MFFKRRSRANSYIENDAPQRSQSYDDYEKVRPESSHTQQTQQTQHTQQHQRVSSPTEQDMYPRPQQPQEPQYSRGISNGLNSMTLGQPTPPLSSGMKPEPMPDLLTHAFNQAVRPYTEKIEQLESQLADMQAWVEQLEQQRAEVHSWIDKRGLRPDVPPSVAKIMDTTTADGALTLNAQLDRKITIVNFDLHRLQDDLNDSISSAHFASAMLKFLPDIQRLALLPSGPRHAFDLVLKLGGNLNSHGGLDSGDEDDLAARRDFYGRLDTAMVDVVSRRFGEGEEWNVQREIKRIEKTAQYLSTYGIKPYFPQTLDVMRSETEHRGGGYQSTNGAQNGQGSPPRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P437</accession>
    <name>A0A9P4P437_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_399735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P437"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF84">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="182"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2437964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="279" mass="31217" checksum="31990682E6F0A8A6" modified="2023-09-13" version="1" fragment="single">MAVPQLHELSTFPIRDPEIDPPFSTRDPEAVPPFRPGEPAQPARFAYLRRVLSPRNDSTAPSKRSRLRARLPKFRAPNPPDRPTFKQWLRRCWLDILTQLLCILTAFIIYLTVPPLLTHYFPLYPGIYSTPWGLKHGQPYINEYINTTWSAAISFIVPFLIMLAVSGWWFNSFWDGNAACIGLGYALATATLFQSLIKIFIGGLRPHFLSLCNPPIPPAYGAIGQAPGAIWYTADVCRGDPHILREAQMSFPSGHACAAFAGFGFLALYLNAKFGVFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P545</accession>
    <name>A0A9P4P545_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_506319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P545"/>
    <dbReference type="OrthoDB" id="5386682at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="55851" checksum="0792EFC8A815A372" modified="2023-09-13" version="1">MALVAREFRLTNNQKSSWRLELGPWKGLREFHDHVYWTRGWIFQEMFLSEHLVFMCQEVFITVQQLKILYSALYRFERSRETYAKRWIENWYNFSMVQLSLLWKTRSLETRSDQMGMLQRILVLTTKLRVSDPRDKIYSLIALAELQETLKPDYSIPARSLYISTCNELLGFENGLNFLAMGRMPTLDQHLTTNPKVSSWVPNWHAVSQHAGSNPTLELFLQGDHYKAADTLNGSPLILESPYGAYLAVHGFVVDTVQSVHTAAAHDDVGDQLMAHIISILNSPNKKELELPVLQVACRTLTGDAVGDIRIPCLDPSSFIDLGFAFVDLVAGEHRTTLEKQPFHVSPFYDIFPGGLNQKTMGIAVSEHFLGSTWIPRYRNPERIRSISPTEQLLRIDTRKAEFMERGLSCMRLRTVIRSSKGYFGHAPLDTKVGDQICIFKGCAFPVILRKQPHYVYVGPCFLLGFMDGEIVGMAERGEVQEERFVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P602</accession>
    <name>A0A9P4P602_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_505780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2438000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P602"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="559" mass="62940" checksum="8E860F095A0E883D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6Y0</accession>
    <name>A0A9P4P6Y0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_124222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6Y0"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="89"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="268" mass="29442" checksum="2DFAB325E6D17967" modified="2023-09-13" version="1">MPPRNHLAIAIHPLQYADIHACARITAAAFSTDRHTIVKQLGGKPFDMCDVSRDGFLATLHKKNYIYVKAVDSAGNIVGHAGWGFRGVEETKIASEGPADSLEDCEKDVEKRGGDDLSEGRLESKTHGEKAENGIDRLHALEDADMQHAMASLMPPSTSCMYIAGLIVSPAHHSKGVGSALIEFGNANADRLGVFTWVHSSDQAWRAYAKFGFEVVRELHVDLDDYAPSPPRKGWAERLNGTGEGVTEDRWGKYTIRYMKRLPKAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7D3</accession>
    <name>A0A9P4P7D3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xenobiotic compound monooxygenase, DszA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_467370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7D3"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="145"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2438208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="440" mass="48867" checksum="5F9B17C00770B616" modified="2023-09-13" version="1">MDSNNRAELRSSAKNSEWNPCCIPRTSLQRTFFKKPREDHHGEADPSRKKLILNAFVEMCSGHQSPSLATWYYDTSTEFNSISHWVHLAKLLEAAKFHGIFIADVLGGYNVYRGPRNPAPALKSGAQWPANEPLAVTKHRGPPHRGRLGWDIVAGYLDSAARNLVDSEQPEHDGRYAMAEYIKVMYKLFESSWRDDAVLLDRQRAIYPHPALVREINHEGKYYTVPYPHICQPSPQRTPLLLQAGTSKAGKTFAAQNAESIFVGGHSPSVVAEEAKAKSDDYAQDGDLDGALALFGVWTGIDLAVYHDDEELRHVRPNAIRSTVEAWSKASLGIPKWSKKTVAKNITIGGLGATVVGTAAQVADEFERWVKEADVDGFNILLIPELRRRGLFWDEHLVQGGTYRENFYGRPGESGPLGGHVASGYRWRKGVSVEEAGIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8T5</accession>
    <name>A0A9P4P8T5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_126075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8T5"/>
    <dbReference type="OrthoDB" id="10503517at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="287" mass="31785" checksum="D5C9AB309B20769F" modified="2023-09-13" version="1">MFNLFSSFSDKAPPQDQTMADAPPVTVKKEGDSTEARAGIAEATMVSAQEDVDKDPRVAAVKATKDRFSEEARKALESVARMEDEFKKFRGILLSIQQAERGYSVELHQIEESFQGQQDILRLHTDQIDSTEDAETNFEAIDEANAKIRELHSTKKKVVSMLNQSQIDREDLEIRLSTHQAEVNRVMNQVQDLAQGQPEQKRHNPGARKRDSSGTVKTLTDVAGTVDPLSPSVRPANPRTPSGRSRSRLIASSRIHKPNPSSSDVVPSSSHPSPGPTKDDPDEIDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9G2</accession>
    <name>A0A9P4P9G2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_477227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9G2"/>
    <dbReference type="OrthoDB" id="10680483at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="802" mass="90610" checksum="2A284C0D58837EE8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA43</accession>
    <name>A0A9P4PA43_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_489907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA43"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="11"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="104"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="232" mass="26129" checksum="72F7D27AD8397D90" modified="2023-09-13" version="1">MASESLKSTYQQYKRDTEVVASWRANTAREHGYDNPLGVDGSIPAPVKPKAQKKGKECYAEQTKRVTSLRSETPHRSLNTSLLFKMRRLRYLSGLTSSLKELFEYFVDVLGQVKKTLQSLVPEWTGVPGKSSVKSTPADESSRTIPSLQNLFQALAVYEPSAAFEAAPDVERPAPMETVFSVEQDSLFGALFALTTLMGDLSRLIEEIVQLWREYGRPGQHHRRISSHRYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA51</accession>
    <name>A0A9P4PA51_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molybdopterin binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_490042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA51"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02110">
        <property type="entry name" value="SO_family_Moco_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF6">
        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="6">
        <location>
            <begin position="138"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="7">
        <location>
            <begin position="345"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="521" mass="60223" checksum="E5535E81060020F4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAG4</accession>
    <name>A0A9P4PAG4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_422241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAG4"/>
    <dbReference type="OrthoDB" id="5391602at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF134">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="371" mass="41478" checksum="166FAB3EF632E069" modified="2023-09-13" version="1">MSTNAAGLYVLCSLLPALSTIAVGARLYVRNLKKQKFSVDDGTALAGLIGLWGVAGVILDGTRRGLFGGNSNLDPVTGALLRSWREGPNVKYSWIVPIITVVALAPIKLSVIFLYRRVFHISRFFHYYSIFLCVVLVAWAIAFMFASIFQCGTRSWAYWTTVQTIRQFCGDTGGANVALCFSDLFIDILILIAPLVMIWKMNFSMWRKMQIVAVFALGFVSTAAAAARVYIMWEDAYDTKRGHTNLIRENTKVVMWCLIEISSALIACCLPVLRPIFADTWVSRLFCKLQNRIHPEDPSISPTDRQLEEGMAFRSIGGTDFNVVKRDSMSRKDSKMSTNVESRETDPTSDIEKSTGQIDVMFKEINISKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAR4</accession>
    <name>A0A9P4PAR4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_488019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAR4"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="13"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="39281" checksum="F8F7C873C8F3132A" modified="2023-09-13" version="1">MHFDRRELYTDLETRVRYLHSFLDFSSRDIEALISGAKYIKALIPALVNIVYKKLLQYDITARAFETRSTSYEGPVDMNLNETSPQIMHRKMFLRAYLTKLCSDPSKMEYWEYLDKVGMMHVGQGRVHPLHVEYIHIGVTLSFIQDVLMEAILSHPRLKMDRKIALVKALSKVIWIQNDLFAKWYVRDGDEFLEERLVPEIEPEGYLHGKKILRSGSDSEGEIEDADMATGSCPFKNLVTPVASGPRVAPKSPLSSHLEGMNLNDEPASTPKTEPAESRLSPSPIPPVSPTISPSAIPRPVPGRRLGGVVLAEAGIAPSHRALKTSCLFNKAPKVLRERRAKVHSAAFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBE6</accession>
    <name>A0A9P4PBE6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_368151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBE6"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="59114" checksum="D20D6C0782ED39F9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBG2</accession>
    <name>A0A9P4PBG2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_365529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000206">
        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="295"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="456"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="848"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1139"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1291"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="913"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1022"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1150"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1174"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1207"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1313"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1338"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2441940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1379" mass="152204" checksum="93A46C0BE3FB974F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC50</accession>
    <name>A0A9P4PC50_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P171DRAFT_435021</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC50"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="20">
        <location>
            <begin position="99"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2441361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="332" mass="36330" checksum="BE78B4AC37C1336F" modified="2023-09-13" version="1">MLARSALRSARPVGAAARNAASKTASRSASTSSSTAEGTSSWKTNALPVGATAFAIGTVAWYAYIAGRDVDAMTPAEEGLHPTQYPWEHAKWNKTFDSQALRRGFQVYREVCASCHSLSRIPYRSLVGKIMTVDEAKALAEENEYDTEPNDEGELEKRPGKLSDYLPSPYKNDEAARAANNGALPPDLSLMVKARHGGCDYIFSLLTGYPDEPPAGAVVPEGLNFNPYFPGTGIAMARVLYDDLVEYEDETPATTSQMAKDVTEFLNWAAEPEADDRKKMGWKVLAVTSVLTALSIWVKRYKWASVKSRKLVYNPPIKSPILSKLPKPTNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCA1</accession>
    <name>A0A9P4PCA1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AAT family amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_102761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCA1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="83"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="589" mass="63789" checksum="D7A52E6DAD971731" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCM5</accession>
    <name>A0A9P4PCM5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_434032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCM5"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2442554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="119" mass="14067" checksum="C80D20BCE7C2F49E" modified="2023-09-13" version="1">MSTAVEPQAAPVAEVSAVKGMRKNGKQWHDNKKAFRPRANQSSFEKRAADRKAFDATKAKIKEMKDEKEAERQRRVEAIRTKRAAKEEKERFQKMEEKMHKKRVERLKRREKRNKMLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCS5</accession>
    <name>A0A9P4PCS5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_446420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCS5"/>
    <dbReference type="OrthoDB" id="2968825at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="252" mass="27817" checksum="8C5BB521B1F62E73" modified="2023-09-13" version="1">MVLIKKICAPQDVQATLTVRLTTASPTVSLSSLRTSSSEPILEFHIYIRCNSSKQPTRPITISTQGTIFDDSHRPEDGHMDNLALGMLGGGLTCATEAGLKRISFGYFKIHRARQDNGNALDLRDRPDAAFLTIPAQDTGDEVVVKHTLTSERLFAYADGRNVDDLLVGERYKAHLSDGYVGATWWRWGGLEDELKNKKLHPSTKKTIGRWGGEESDIGKLEKKGWVFGENRAQLVFEVEEGGGSCEIGIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE38</accession>
    <name>A0A9P4PE38_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_523627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE38"/>
    <dbReference type="OrthoDB" id="2129288at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="163" mass="18264" checksum="9A01630DF115A465" modified="2023-09-13" version="1">MPLWIIYHPRSIFTSEAEKTAFSKDVTNIYTAVPLPAFYVNVLFVPLDATNIYVGSVPRPTPHTAANEPGPDSSVPFVRITIQNIARTLPNDAARDRFLGAIDKALKPHIADKGYDWEYSVEETRRDLWKIQGIVPPMPGSDAELQWTRENKATAFEPARGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEV2</accession>
    <name>A0A9P4PEV2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_390468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEV2"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="57709" checksum="65125648D8971440" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEX3</accession>
    <name>A0A9P4PEX3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_446542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEX3"/>
    <dbReference type="OrthoDB" id="3789421at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="274" mass="31552" checksum="7520EC0BF4BDA289" modified="2023-09-13" version="1">MAQDSGEGARANMKRKFDIYCLDQSLVHFKIDKKVYCVDESLIEKRCGGGSWLDYIGHKENLKTTLPEANQIDGIVWAGCIGCPHDWTRQSNESLCIFRGFIYWLHEHELPSDEMIKQMDYPTQWNEIGGDKPLALAMAVELYQQAGYYKMAKLSLEMLQFIFIHFKRCSSAPQTGLLRLVCSSGEMFGEHPLERFFVDIYYKRCDEESMGLEDDYPLGFLFSVIRLKAQRNKLFAGKGKEENMVLRLSDYHINGSEVFCPTTKEETGDTWVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEY5</accession>
    <name>A0A9P4PEY5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_390639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEY5"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2442770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="430" mass="47898" checksum="26035A627B03E50B" modified="2023-09-13" version="1">MAPLKILVSGGGIAGSCLAWWLNKAKIDAQITIIERAPEPRTSGQAVDIRGAAVDVMKAMGLEQAIRNKNTTEVGFEFVYSDGVSKSRIAATGDDKNQSFTSEYEILRADLANIFYDATKDMKNIEYIFNETINDLVQDAQADKVHVTFANHLPQAYYDVVVGADGQMSQTRRLAFGHGPQNGDYLRRLGEYMAFFTIPRIESDGQWAQWYPATRGRLLCTRPSPYNDTRALMGVVDWDLKRFSEIENLVKKRDEEGAKKWLAKEFEGAGWESQRILNSMTTTEDFYIQEIVQVKMGEEGFAKGRVALLGDAGYCPSPLSGMGTTLAIVGSYVLAGEIASSPSDIPAALQRYVTTLRPFSDHCQRLVPGMPQVLFPQSAWGLKIISMLTTVITSPIAQHIGPWVKMLLPRGFHRDRWQLLKQYSGMPVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF77</accession>
    <name>A0A9P4PF77_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_455828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF77"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="19"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2442862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="509" mass="55617" checksum="774BECE5158C2D7C" modified="2023-09-13" version="1">MFGVSTIAGHGSTPAVTLRNDFFLGIPFAQPPTGDLRFPNPRPLQVSWKGERDATTFSPACVGYGASQMGYNISEDCLYLNVRRPPGSNMKHHGGFAQGSGVDLRYNTSFMVQESVSLSQPILVNQVRDSGDTNVGLRDLRLALQWIQENIASFGGDPGKVTIWGQSAGAGSVGIRVMAYNGRDDKLLRSAIMESGSPVAISDPDRKGYYQAAYHHLTQLAGCSNAPDSLECLRSLSFEKLNAAVNTTALNSIWFPQIDGDIIARHSSEQLKEDAFVHVPILIGTNSDEGTSFTPKGVNNTEIFKKAIQGSAPLMNASFADRVLVAYPARNVLANLDPTYRPGPPHGAQYRRAATYYGDTQFIASQRLTCETWSAAGLTAYCFRFNAIPVWATILDGATHFVEVAFAMLNVLGVSYPPVRIPPFEEKPPSYDNLARLTSGDWIRFVHTGDVNSKARSRSFGVPRWPRYSLRKPEGSVYDANVTSHVEPDTYRAEGISLINSGVFVVYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFP7</accession>
    <name>A0A9P4PFP7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_464111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFP7"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF267">
        <property type="entry name" value="MALONATE--COA LIGASE ACSF3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="371"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="691" mass="76448" checksum="031BE8E34C6D5B96" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG14</accession>
    <name>A0A9P4PG14_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_521739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG14"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2444400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="116" mass="13119" checksum="F37826D7587E3064" modified="2023-09-13" version="1">MSYNKPEKGDFEGPKIHKIRITLTSRNVKNLEKVCTELIDRAKGKDLRVKGPVRLPTKNLKISTRKTPNGEGSKTWDTFEMRIHKRLIDLNAPTEVVKQIIINIEAGVEVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHA1</accession>
    <name>A0A9P4PHA1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_485116</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHA1"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="648"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2445044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="681" mass="75292" checksum="68A1DBC4DC01CA86" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI12</accession>
    <name>A0A9P4PI12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_414247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI12"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF2">
        <property type="entry name" value="TERPENE CYCLASE AUSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2444312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="255" mass="28806" checksum="7989DFDD61E7E503" modified="2023-09-13" version="1">MGLFALEEWAQANADYDNDTPPYWHAKIVPDLFTAISGILWSISYILMTLKGYKDRSYAMPIYCLCLNITWEFVFGFIYGPGLVNQIVFAQYMVVDVFLFHSILKFGPNEWRDHPLVARNLSWIIGVGCTVCMGLHLAVAKTFVPVVGRQVIFFTAWPMQHMISLGCTAQVLSRGHDGGQSMGIWWTRFLGTVTAGCCFYWRIYFWPERFGYAWSPYGALLLVGSHVSDLAFPFALAYVRKHGGGRQGRVNGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIK5</accession>
    <name>A0A9P4PIK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_389957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIK5"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="610" mass="69359" checksum="B137B9D403121966" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ05</accession>
    <name>A0A9P4PJ05_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_359358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ05"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2444887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="85" mass="9800" checksum="658CC3298D3ABFA2" modified="2023-09-13" version="1" fragment="single">SNWKLSPSNKAISRQFTFPGFASAWRFMSIVADECKAKRHHPSWHNLYSQVTVEWTTHKPEGLSIKDVEMAEFCDRTADEVGLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJY7</accession>
    <name>A0A9P4PJY7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P171DRAFT_521611</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000015">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1523"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2444251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="2232" mass="255096" checksum="3716B27CD83C0B36" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK17</accession>
    <name>A0A9P4PK17_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_442872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK17"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="150" mass="16170" checksum="CB6FE73D7EC4DE6F" modified="2023-09-13" version="1">MGFLDTLIDAMLPRKAGRSSGRRRRTQREPDPDQFLPPIFPDVGGPGGPPAAPGPQFGTQMRRNQRTVDGYQTDQPEFFRQGGRRAGPGLPALSANQFGAGRSGQRGSSRRGSQGGRSSRRSEHGGGGMYAPHSASRGGRSQLRPSRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKI8</accession>
    <name>A0A9P4PKI8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_463212</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKI8"/>
    <dbReference type="OrthoDB" id="3740995at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000272">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="90"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1037"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="481"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="832"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="902"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2445876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1221" mass="136696" checksum="17873A2B55268B59" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKS6</accession>
    <name>A0A9P4PKS6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_429848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKS6"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="156" mass="16999" checksum="391EF8C0894E2055" modified="2023-09-13" version="1">MQSTRALLRLPRQLSRRANPSRALGTTAPRLSSSFPTAPAPPRLPKEEQEIFDRLQKQSTGAFSTPREEAAATSTSVSFSAADVRARINQSPNSSADEPKRIPEGEEVHPNLRRGAPPEFEGDVNPKTGEVGGPKVEPQRWGATGDYSYNGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKU3</accession>
    <name>A0A9P4PKU3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_431886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKU3"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000008">
        <property type="entry name" value="Beta-N-acetylglucosaminidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000013">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="636"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="936" mass="102084" checksum="E1B792036C0594A3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLJ8</accession>
    <name>A0A9P4PLJ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLJ8"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="22"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="265" mass="28802" checksum="B6D97C9A9CC5FA2C" modified="2023-09-13" version="1">MPFLQIGYKKIHYTDLKPENSDARETFIFVHGLGSSQDYYHAVASGLQAHNFRCITFDTTGAGRSPYTQIEQSIQSLADDVIGVLDALEVSKAIVVGHSMGGIVGAHLAAERNDRVVAAVLIGPVYPNPGMIPIFEKRIQTVEKEGMEPMANTIPNAAVGKQASPLAKGFIRELLLGQDPAGYCSNCRVVINAKPPAYEKIAVPILILAGDEDKSAPLEGCQKMFNEIGTGEKKLEVMKGIGHWLALEAFEQVGQHILSFYHDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLL3</accession>
    <name>A0A9P4PLL3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH dehydrogenase, alpha subcomplex, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_519616</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLL3"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000219">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 10.5 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="94" mass="10735" checksum="8FDB71BB03AFBA1B" modified="2023-09-13" version="1">MASKYGFAKQLKELRFLFCQTSDHSAATRSFLTKSYPTMKKHNPYTPILIREASGTEPKLFARYEFGKEKSVSLKGLDDKAIEQKVTELVKESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLQ0</accession>
    <name>A0A9P4PLQ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_512281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLQ0"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257:SF1">
        <property type="entry name" value="DUF1330 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29772" checksum="1A9A764B6856CDED" modified="2023-09-13" version="1">MPLCTLHLVALNHTTPNPQQSFLSALKSTNLSPLVVSRVIRWIILPSTFSTEHLLARNIHWDFLLILSGTDALPSPLTSRIQHTWRITAGVPSRLTQDFAQKNAKLLKPDTGSVPAASSAALSPARTASSAQNLELSTDLKDWIRTFSTNGSPEAKGAVSMFNLLSFRAGKKASYLEYGKAFASSIGASHGGTAKIVGGVTHVEGVPRADGVEDGEGWDEVALAHYPSILHFAEMLGDENYQRVNREFRVPALRDTCILMTSEVGVEEGVRGGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM18</accession>
    <name>A0A9P4PM18_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate-binding module family 48 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_260043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM18"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="415"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="528" mass="57528" checksum="0265B0631DE63C92" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMA6</accession>
    <name>A0A9P4PMA6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_239589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMA6"/>
    <dbReference type="OrthoDB" id="5422958at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053274">
        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065:SF1">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065">
        <property type="entry name" value="FREQUENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="68"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="314" mass="34155" checksum="50378C2CF501209C" modified="2023-09-13" version="1">MENNQSASRAAQRFLMDRVRTDWSWPDVPDAWSQSDEEVHGVTSFRERFYGDSSPSETEDEGADGSDPYKFDSPDSIRDAVDRKAQRKKRQRRAALEGEMKVNEGLRTFVERRDAWTGVASVKKYGTAGRPAKTQNAAQTVQAERSPSITADMSSSNAPTPMSVDSQVSAAAAHDEAFRTAVATSDEPLVPVAPPLLADNAIRKSITPRTYPDIFNKIVVSSRTPSVPVNLADMTKALVAGWKENGEWPPKAAPLDPLAGKKRAALAAVRAENGEPFLAHHPHLQKGMDSVRKIFHLNGQVKESGHGSGPANTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMN8</accession>
    <name>A0A9P4PMN8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_471430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMN8"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040113282" evidence="1">
        <location>
            <begin position="25"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="391" mass="43206" checksum="6CEADCDA80759813" modified="2023-09-13" version="1">MLILRALLALPVFLSSTIITYALAAPGSSPQGSDESDGFLDVDKKEPFLNYAASLTGGEGCKDNDLKWIRDGFDEMNTLFAAAQDPNFENQSEIDFFGRPFRIGNFTDLIRANLRRAGQYGNLQGAAIVNPDIHVRCDDPNDICNEGKKKDGKHAAYNIGNRPHINFCERYFTLDPLEEQVNDESSNDQAKNYLINYYNRATLWARMVMHIAEIGEAVVMKATPNLQPNATREWILNSAPGPMKTSVIAGAMDDKDGPMNIRVLRYAYGVTRAKLIATLSTQNAYDALSNAENYAMYALARYVVQKRGFFPNLPLVNFGNDMAVLTNDQIMDGDKKKFACFDKPDVVPRMDGVMQAGARLSSSAVGSHMPSAHVITLVVVVMWYLAGYAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMR9</accession>
    <name>A0A9P4PMR9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_482691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMR9"/>
    <dbReference type="OrthoDB" id="3433125at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="138" mass="14735" checksum="76A8118886C29B24" modified="2023-09-13" version="1">MDEAVWELDEAQDQVSEHQSRPAAATEEEVAGPANLFLVAHARPPPYFAGQLALPVAITQQRPASRTKGFVRAYSPLLDDAGIDQTTILDFLDNPNKSLAPSPCIQAINLAAFAGQKVPEPFTIMISIAVKKVAGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMS8</accession>
    <name>A0A9P4PMS8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_471285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMS8"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040452802" evidence="6">
        <location>
            <begin position="17"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="437" mass="47801" checksum="42AE25D0071AED29" modified="2023-09-13" version="1">MLLIASICTFSPMASSLCAPGTSLTLAEFNTDDRTIGSLMISIFVLGYAVGPLFLAPLSELYGRTLIINASSAFFNAFILGCSFAPNMSSLIVMRLLAGIGGSACMTIVSAIIGDVFKVHERAAASAIVVGTPSLAPIIGPIAGGFISQYLGWRWAYWILVMGSVPLNIAMIFYMRESNHPTILERKTKRLRNQLGRPDLHSQLEMRLPPRQVLARSIVRPAKFLFRSPIAFLISLYVSIVYGTLYLLFTTIPDVFQNTYGFEIQYTGLAYLGLGLGMFLALALVVKFNDRTVLRMRNKNGGIFEPEMRLATTPYFAPFMPASLFIYAWTARASVHWIVPCLSFIPYGFGLLGIFVPCQTYMVDAFLSTAASAVAALVCLRCIFGALLPLVGPVMYARLGLGWGNTVLGLVTVAVTPVPFAFMKWGGLVRKRYPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMW6</accession>
    <name>A0A9P4PMW6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_520481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMW6"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2445736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="142" mass="16102" checksum="A27ECE7F4E3BF4B4" modified="2023-09-13" version="1">MGREHLTNDEFFAQLNNLFEYNRDKGHGSVYLSQKRLAFDTRSQPQTLTKVADDPLWDTHPENPLPILIRAHNNKSSKRNGTDRGDVDKISLSTAVQPDQLDAFFVQYAEACKAGMSGLKKRDRRGKKDKKKRKKGAAETKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN31</accession>
    <name>A0A9P4PN31_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide chain release factor eRF/aRF subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_410196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN31"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="437" mass="49055" checksum="365A856C39DB1891" modified="2023-09-13" version="1">MSAPPQGQGADAEKNIEIWKVKKLIKRLEAARGNGTSMISLIIPPKDQVSRAAKMLAEEFGTASNIKSRVNRLSVLSAITSTQQRLKLYSKVPPNGLVIYCGEIITAEGKERKINIDFEPFKPINTSLYLCDNKFHTEALSELLESDQKFGFIIMDGNGALFGTLSGNTRDIVHKFSVDLPKKHGRGGQSALRFARLREEKRHNYVRKVAELAVQNFITADKVNVAGIILAGSADFKNDLNQSDLFDNRLQTKVIKVVDVSYGGENGFNQAIELSSETLGNVKFIQEKKLINRYFDEISQDSGKVCYGIDDTLKALEAGAAETLIVFENLEMTRWQLKSSEGSEIILHTTKAQEVDRTLFMDKETGQEMEVIDQMSFLEWLAEKYRDFGANLEFVSDRSSEGNQFVKGFGGIGAIMRYKLNFEQLAEYDDEDEFYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN40</accession>
    <name>A0A9P4PN40_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_245474</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN40"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="243"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="468"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="657"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1062"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1102"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1124"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2447090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1229" mass="136548" checksum="4DFC26E78C5F3FC2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNE4</accession>
    <name>A0A9P4PNE4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_440714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNE4"/>
    <dbReference type="OrthoDB" id="10596853at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="260" mass="29827" checksum="FE48594F9CDE061D" modified="2023-09-13" version="1">MRPSGDRTMVLHLCCSLAGWCRRYGSAPTRSSPRYFSHQWPSAFTHWNCSIWRFYTSTVRKCTWPGSTHRDTATTVSVGTCEKKRLAYKQQKDRNDAVRQRKKSLDSQKIYLQTEAESGKIELERANATWKERVRELEAIKAFYEERFGSYNELVKAQQEDAEGMINMNEVQDELGVSFQVAASPGSDFPGYVDDHEFDQYNEGVEPNEQGNDGQEYDSLDPGLEEQDFDQQDLDEEDIDQFDDDEDTSSLPAANTGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP35</accession>
    <name>A0A9P4PP35_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_430764</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP35"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="61"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2446673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="570" mass="62377" checksum="9F436C8714199423" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPC5</accession>
    <name>A0A9P4PPC5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_429340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPC5"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2447722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="363" mass="40202" checksum="76F82264B9C037A2" modified="2023-09-13" version="1">MSSSSQVTESWISSFCGLLGHEYFAEVSEDFIEDDFNLTGLQSQVPMYKEALEMILDVEPEDDDDEEEEEEEEDEEDDEILGDERPAAYRRASDRRHLRIASDLSVIESSAELLYGLIHQRYITSRPGIQQMAEKYELQHFGTCPRVHCNSTKVLPVGLNDSPGHDTVKLFCPSCLDVYTPPNSRFQTVDGAFFGTTFPSLFFMTFTDLDIGSGIRNNSSSAAQALLQIQTETAKGTNTTPANVTSINGVAPHNLAPGIGAGNIYEPRIYGFRVSERAKSGPRMKWLRMKPADVTELDETRRYWENPPDDADRPHDDDLNMVDVAEGKSVDSRKKISARRKRTNGSGNGGGSLIDTNGVGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPW7</accession>
    <name>A0A9P4PPW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_453248</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPW7"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000001">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2446819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="321" mass="34792" checksum="092F74244195A257" modified="2023-09-13" version="1">MATNSIKLLTGNSHPQLANLVASRLGIELTKILVLQYSNQETSVTIGESVRDEDVFILQSTPPGDINDALMELLIMINACKTASARRITAVLPNFPYARQDKKDKSRAPITAKLMANMLQTAGCNHVITMDLHASQIQGFFNVPVDNLYAEPSTLRWIKDNLNVKECIIVSPDAGGAKRATSIADGLDLPFALIHKERARPNEVSKMVLVGDVSDRTAIIVDDMADTCGTLAKAADVVIQHGAKDVIAIVTHGILSGNAINALNGSKLKKIVVTNTVPHEEKKELCDRIETIDISPTLAEACRRTHNGESVSFLFKHAPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQH3</accession>
    <name>A0A9P4PQH3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_409400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQH3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2447041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="540" mass="61272" checksum="D22E6249E1945CA6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQM9</accession>
    <name>A0A9P4PQM9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_481466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQM9"/>
    <dbReference type="OrthoDB" id="2117996at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040163514" evidence="2">
        <location>
            <begin position="17"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="488" mass="46067" checksum="E1B4311EF3B7B49D" modified="2023-09-13" version="1">MKYLILSALLASAAIAAPTPAKGNQGGNANGGNNANANNNQAGVGAGAAQGTAGNAGAAGAATGAATGATGAATGATGAAGTQGATGQTGTTQPAAGTAGTVTPGTSSAVPPPPGGAQGQTPSAGDLATAVANWMADTSMVSMFLNNGPTIQDDTAFKQAALVAFNAEVDELTHKAVIDAANGQLPNVQAANSTLATGGAFQDVVDKLQIMSQQGKAAANNIDLINQNRCTNVLPNIDAYMASTGSNSQAVRPNVCDQTGVVGGVQSNGPTQPGQTPGTPQQAFDAAQALASGTGNGQMSQTPANGGTAQAGANGQAAGNGNAAGGTQGTQNGQNAGANTGAQQGQQGQQGTNAGAQQGQGAQQGTQGTQGAQGTQGTQGTQGTQGTQGAQQGTQGAQGAQGAQQGQAGAAAQQQQGGNTGAQQGQAGAAAQQQQGGNNGAQKGQAGAAAQQQQGGNAGAQRQGQNGAAGQQQAGAAAQGTGRNGNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQS9</accession>
    <name>A0A9P4PQS9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_427771</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQS9"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000010">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00410">
        <property type="entry name" value="PHEHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="17">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="151"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2449590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="420" mass="46672" checksum="39399D70FA26AC5D" modified="2023-09-13" version="1">MAAALTPEQTAIVKSTVPVLAQHGETITTKFYHDMIAANPSLKNIFNNTHQATGHQARALAGALYAYAANLDDLGKLGPAVELICHKHASLNVKAEHYNIVGEFLLKTMKSVLGDAATEELLDAWGAAYWQLANIMIQKEAQMYAATSYWPEWQDFRIARKEKESEHITSFYFEPVDAKLKLPVFKPGQYVSVSLFVEELDGGVWQARQYSLSDAPGKPYLRISVKKEPGIEIGEPKHMTHTGYLSNILHEKKEVGDVVKLSHPFGDFFFEEKAVEGDTPVVLISAGVGLTCLMSILNTLVEEGGSRPITWIHGSRDSKVRAFKAHVDELAGRERSIHKLYFSSSPAADEVEGQDYDVQGRINLDKIEKDHLFTENKKTQYFACGPTQFMLDVEAKLKSFGVDSERVHMELFGTGGVPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR12</accession>
    <name>A0A9P4PR12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_428648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR12"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="405" mass="46721" checksum="E0C3E0C0B20922C3" modified="2023-09-13" version="1">MAIPKAMRVLGGATFLVFLFVLVTLYRSDPTAIKLPTGGIKEGILPGPRPQGWDHDPQLDPSGEAPEPLRRVNGNNYAPDNANSDRINATLLSLVRNEELADMLQSMHDLERTWNHKFNYPWTFFNDVPFTDDFKQKTTAATNAKTSYHTIPKAHWDIPSWINKDLYAASKKALADKGVQYSEMDSYHQMCRWNSGVFYQHDALKDVQYYWRVEPKVHFFCGVDYDVFRWMQDHNKTYGFTLTLLDSPDSVKSLWPETLKFLADHPEHEAKNNAKGFLTEEKEKGHNHITGGYSTCHFWSNFEIADLSLWRSKAYTQYFEHLDKAGGFFYERWGDAPVHSVAVGLFEDKSKVHWFRDIGYQHIPFFNCPNNGKCSGCEPGRFTDGEDWLNSQDCRNVWFQNAGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRC5</accession>
    <name>A0A9P4PRC5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_408367</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRC5"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2447858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="419" mass="46463" checksum="79867345FFD22314" modified="2023-09-13" version="1">MLQQRSLRLLSSLSQRSIRPTAACAAASLRCRTQRQYSIHADASVGTAIKDIEPSKLSITKTTTPKALLPPEELIFGRNFSDHMLSLEWTASEGWLPGRITPYQNLSLDPATCVFHYAFECFEGMKAYKDKNGGIRLFRPERNMARMNKSSARIALPTFDGDALIELISKFLKVDERFIPDARGYSLYLRPTMIGTQRTLGVGPPASALLYVIASPVGPYYPTGFKAVSLEATDYAVRAWPGGVGDKKLGANYAPCILPQMQAASRGFHQNLWLFGEEEYVTEVGTMNLFAAIKNKETGQPELLTAPLDGTILEGVTRDSVLALARERLEPKGWKVLERKFTMKELADAADEGRMMEVFGAGTAAIVSPVRRISWKGRLVECGLAENEECGPITGQVKDWMEAIQYGDEEHPWSYKVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRV0</accession>
    <name>A0A9P4PRV0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_438854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRV0"/>
    <dbReference type="OrthoDB" id="10647279at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="303" mass="34267" checksum="3541C45CF4B73274" modified="2023-09-13" version="1">MSIQNLVDTDLVEDAMGITASGNEHYNGNDDQGIRVSGPKTADTIQPGSFTAAEWHEASMQYLEHTEARWAAQQSAKFTVLPSVPDQPKLRTDHEEKASLRTAQDESSDAHGQESVEIFIPDPANKDIIICQICQKPVHRRHISVHSTTQKHQRLSATSRTDRAFEPAKEPQYFCEVCQRSVRQSYLLKHEATDLHHRRLVKQMDLPVAPAPKPAVGAKVPKHKKTYEWTAEEDETIVRAYVDLKDDEGIAGMLPYRSVQAVAQRRRDLTNPRPTVSGSWEYSALYLRILWEKNGVQRNKPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRX7</accession>
    <name>A0A9P4PRX7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_186750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRX7"/>
    <dbReference type="OrthoDB" id="5429780at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="298" mass="33549" checksum="C9980B926CA9D579" modified="2023-09-13" version="1">MHQGIKDSTRRRIMDTRFDRLRLSQSAEFWALDTLDISWEFLDGLDRRLQKSKDESDLRSISPDMTTKPSKAVKPDSSLTTTLHSGSLELKAAVEEETPTHVPGRVLVYKGGAYSRIISIFHQDGSLNLRQIVSTPPCDFHPDRRDLYFTKQRDVAVDYAEWAHNRVPPQEPAVLTAAIPAEYTSSSVEIFGDDWKKLVWFSRNMTALLDNGGVLPKELSSYTEADVLIGHICGIGSAQIERMASADALTASKTKTGDKATQIVLNGHTMIIKFREECRGYIWVASMRAPKRAKHFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSI9</accession>
    <name>A0A9P4PSI9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_191828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSI9"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="577" mass="63010" checksum="F0FBA16DC3476342" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTH1</accession>
    <name>A0A9P4PTH1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_205450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTH1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040331422" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10372" checksum="1793B180E534055B" modified="2023-09-13" version="1">MHSTVLMWALLPSLPRATSGSTKITFYSELKAGFCYGTVPRMVARLRVWRVYRPFCLNTLPWCRSATHPPQPTGCGFSGSFPCFLLHLSCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU93</accession>
    <name>A0A9P4PU93_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_6592</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU93"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF23">
        <property type="entry name" value="ASPARTIC ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040223868" evidence="13">
        <location>
            <begin position="20"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="103"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2451464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="423" mass="44181" checksum="8B9FDB954E0613DF" modified="2023-09-13" version="1">MATFRIIFFVTLLAALVLAAPTPARIKKRSFKVPRYINTPVHARGLDGGAAVRKVFNKYNLKGGFIALEKTGTFTGLGIKATNASSNGTGTVAANPGENAALFLSPVDIGGQTLNLDFDSGSSDLWVFSSDLPVQSTTGHGVYDKTKSASFKEMTGAKFQISYGDGSGAAGTVGTDAVTIGGVTVQNQAVELANAVSRSFVQDTNTDGLVGLAFSKLNTVNDGTKKIPQKTFFDNVMGDLDLPVFTADLDPDGTGVYEFGKIDATKFQGDMAWIPVNASSGFWQFPSAKFAVGDQIVDNPTASQAIADTGTSLLLVDQQVAEAYYSKVQGAQLSAQVGGFIYPCNAQLPDMSVAIGDSYMAKIPGSQITFATVDEANTTCFGGVQGNSGAGLQIYGDTMFKAQFVAFNGGNQSLGFGEKPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV87</accession>
    <name>A0A9P4PV87_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_439432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV87"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="166" mass="18089" checksum="1F3AC7A729E16618" modified="2023-09-13" version="1">MDRQSLLAWGGASGAGRMNANGPRQQLLARHARRMHKNRRGQITAADPSTFPPFDAAEARALRSRYRTRGRRRRDATRTLSCREMRNCTLTLTLTDSAESAPLSVQPRGAIPPRLGQMCSHAVRFGCPSNSALHLRDALDAGAGATLSSSILTVHTVYKRRGSAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVN4</accession>
    <name>A0A9P4PVN4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_204589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVN4"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="79"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="2">
        <location>
            <begin position="325"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="56313" checksum="A8FD01BCF50CC677" modified="2023-09-13" version="1">MFEAAATTGASILILGLVGYSYTRYYKRNVLSKMENAFTPGDPVLELAAVGKEVPHAPHGNVPTPGTDDEGEYDRWIPREEQARINRIICGEEKGRYHLLLGEKGTGKSSMLIEAMSKIDGEGVAMLEAHADPEIFRIRLGRALDFEFHEDNIGALFSIRGPRDASALLDIERAFNKLEKVALRRRARVGRPLVLIVNQAHLIRDDEDGRDLIELIQQRAEQWAASNLATVIINSDKYWVYERLKHHATRMEVTQVSDLPKDRAMQALKNYRMKYWKEATPDSVLNEVYNKIGGRLTFLNRVAKSQDMIHKCDEICEMEKTWFLNNCGILGTEMDDDVMDQQKYASTAMVLALALHKRYEDMDKTYDDTIGHILPEIPLHQARYIMTRADFIRQHHDLSIFAIDRHAKVRADSVPMQRAFNQICSEPGFEKFLEATLDRIGDIESLGRTKELTFKDLWEGGKYKITSRDKKGNEVGVVEVETVTPPETDDDGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVW7</accession>
    <name>A0A9P4PVW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_425785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVW7"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF18">
        <property type="entry name" value="MALTOSE FERMENTATION REGULATORY PROTEIN MAL13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="548" mass="60512" checksum="7EFB7DAD3289E415" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX05</accession>
    <name>A0A9P4PX05_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_349743</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX05"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040277935" description="Glucanase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2450371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="414" mass="43988" checksum="67D00B91DED37387" modified="2023-09-13" version="1">MAPYVLAAAVLLGLAAAQSLGTTKEVHPKLTTYKCTKARGCKAQQSAIVLDSASHWIHQKNDTTKGCGNWGSGPDPIACPDEATCAKNCVLEGNSDYAASGLTTKGDALTMNMYNKDGGVSSPRVYLLAPNEKEYEMIKLTGQEFTFDVDVSKLPCGMNGALYMSEMAASGGRSALNPGGATYGTGYCDAQCYVTPWYNGVGNIAAKGVCCNELDIWEANKVATQVAPHPCSKDSIFGCTGDECTKTGLCDKNGCGKNPYTTDKSYYKPGGKVDTSKPFTVVTQFPASSGTLQSIVRKYIQNGKIIEDAASTVVMNDAYCSANGASDFTRLGGMKGMGGAMSRGMVLAMSIWWDEGGFMNWLDSGNAGPCNATEGDPKVIRQVEKAPSVVFSNIRWGDIATTFSAKKPRWAREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXG3</accession>
    <name>A0A9P4PXG3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_152167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXG3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="198" mass="22130" checksum="D288B902FFCED27F" modified="2023-09-13" version="1">MASTVSSSSHHRLPCIASSLISRYGQSSARPRRPLDENSSAWHDSKRGQRVHQSASADIHSSRCTYKARKLGNARSVIARGGWHTDVWHHGATTCVRAGVFGFPLRSLSLKREERRTDHPSLIGNCPPQLLPTGASTFCAPPLKLLLPFPFASICPLARLSLSVISRWLSMRALCRRRPTPRSPTWRLRSMPMAWLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXL2</accession>
    <name>A0A9P4PXL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeat protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_427018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXL2"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="342" mass="36836" checksum="504F6673B996CA0F" modified="2023-09-13" version="1">MPISRPIWNLNGKWARLHDAERLRRSSQVLSVIGNTAYIFGGEVQPRQPVDNKLDVLPLSTASSKLETISSSEAPSPRVGSASAVLAGRMCLFAGRGGTDMAAIEEHGAVWSFDPASASWTRLAPADASKPYPPGRSYHCATSDGHRTLFIHAGCPASGRLSDLWKFDVQTRIWTQAADAPAPQRGGASVAYSGGKVYRMNGFDGTTEQGGRVDVYDVASDAWSTETFQADGHNGPGARSVCALLPVRIAQKEKLLTLFGERDPSSLGHAGAGKMLGDVWVYDIMENWWTRLEPAGSDGVPDPRGWFDGDVVRAEEGNDSVVVHGGLGENNERLKDVWVLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PY96</accession>
    <name>A0A9P4PY96_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uridine kinase</fullName>
            <ecNumber evidence="7">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_400904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="7"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PY96"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002070">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="251"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="447" mass="50210" checksum="77CFBC7EE348E264" modified="2023-09-13" version="1">MTSTPTSRIHYSPPWGDASIIGVAGSSGSGKTSLALAIVASLNLPWVVIMSMDSFYKPLTPEQSERAFRNDYDFDSPEAIDFDVLVDKLKDIKNGKVAEIPLYSFEKHARLPQTTTIYSPHVLIVEGIFALHDQRVLDMLDLKIFAEADADLCLSRRLQRDVKERGRDIEGCIKQWFGYVKPNFYKYVQPQRDIADIIIPRGIENKVAISMVSSQIKNTLALKSGKHQLELLRLGKIAEDSPLSQNALVIKQTNQVKGIHTLLMDPKTNREDYIFYFDRIVSLLIEQAVDFLPFTPAQIQTPQGHLYMGLHKSKEVSAVVVLRGGSAFETGLRRTIPDCRTGRILIQTNYRTGEPELHYRALPSNIAEHGLVLVLDPQMSSGGAALMAVKVLVDHGVREDRIVFVTYMAGRIGVNRVLRVFPGVRCVVARMGDEREERWIETKYLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U400</accession>
    <name>A0A9P4U400_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_449997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U400"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="218"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="320"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2437419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="475" mass="49311" checksum="3F010A2B78FFE613" modified="2023-09-13" version="1">MSKTKATKPSADKKASKKVDAPKVKEGRVTKPSQTPKAKSKDIAKSAVVADKKKSKKAPTPEPESEDSESSASEEDSDSSDSEEKTTKAKANGKAKPAVAAKAEESSSDSSDSDSDSDEEMADAPAAKAATPAKAVAKKEDSDSSDSDSESESEEAKPAAKAAKADDSSDDSSDSDADSDDSSDSEKEAPSKKRKAEAEAEPVVKKTKTEASGEEGIKNLFVGNLSWNVDEDWLSQTFAPHGTIEGCRIITDRESGRSKGFGYVEFSNADEAKAAKEALHDSDLDGRALNVDFSQPRQQNQDKGAARAKQFGDKRSEPSNTLFIGNLSFDSTNDTIGEAFSSFGEITRVSLPTDRDTGAPKGFGYVEFGSIQEAQAALDGLSGQDVDGRNIRIDFAAARDNSGGDRGGRGGGFGGGRGGGGRGGGRGGGRGGFGDRGGRGGRGGRGGRGDSRGGRGGFSTNRGGFGDFKGQKMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U444</accession>
    <name>A0A9P4U444_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_437634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U444"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005543">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="508" mass="53495" checksum="5E1E853F74279E84" modified="2023-09-13" version="1">MDFASLKDQVSNLTLYDLKAGVRKVQNAVMNFTEMEAKVREATNNEPWGASSTLMQEIANATFNYQLLNEIMPMIYKRFTEKAAEEWRQIYKALQLLEFLIKNGSERVIDDARSHVSLLKMLRQFHFIDQNGKDQGINVRNRAKELAELLSDVDRIRTERKKARANRNKFGGVEGGMGMGGFPSSGGTGSRYGGFGSESANADYGGYSGGVYGDGGGFGGNESGFQDTQQRRDKFEEYDEGEDEQASAPPRRSQPSSTQARRETRKEEPKPKAPEPVVDLLAWDDGPAPTSSSAGKQPVAANDDFGDDDDFDDFQSAAPVVPAAKPAAASFIAPPASTSTIGASTQFAAPQPQSAAQNNNLNDLFATVSPPPASNSFASPPVATPASATSSMNQPYRPAGYQATGPNYFTSVPIPSAASTPSVASPGIGGKIGSGAPKKAGGDAFASLLGGAGPKKTVTPTQRVTMADMAKQKTSQGLWGAPASGSSTPASQPQGGAKPGGALGDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4S9</accession>
    <name>A0A9P4U4S9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_180996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4S9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="80" mass="9297" checksum="367D337FFB8C3498" modified="2023-09-13" version="1">MMVTGGMHIKRTFAPVFLLHILCPLQRCCLRGGTKKGWAGRETGRFWFLKDLGTMIMWGGWLVSTRCVCHRYHRRVMSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U634</accession>
    <name>A0A9P4U634_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_525835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U634"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="687" mass="76573" checksum="44132B29DD096359" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6A5</accession>
    <name>A0A9P4U6A5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_491234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6A5"/>
    <dbReference type="OrthoDB" id="3798004at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="39"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="407" mass="46212" checksum="96B39E2138E1AD29" modified="2023-09-13" version="1">MPEKAMTTPQYIDGRRVGHIKEQRVHRPTQRTWKADAVHSQGQSHLAGRLPAEVRNLIYAYLWGDLSAILQEEENEEEKEVANQPVIETSRGILNDGSYEEDVDTGRSHPLSLLSTCRKIYLDATLFAFSHHTFKTSMYNVVPTYLALTQLTALLSELHVNAISRLAYDLPFLYPTATNHCATYVTNSLLIFPALTYFEIHTPEVSAARAGALHGRSPVTSPEGFVPLLLSDTLDNIINGHSYMWQKGEKWSVKWPQEDDPDCIHTASMHEFSSTGFVEEGNSKRRYPGIPRRLMSPCVCGCGAPCRNSAVLCHEGGRQPVTLQLKYHNKEDGSVKPQVERITGLPEGYDFQRTIVGGSRTMAFEWNAEGTDFWKRHRAKETWSATFARWWKKREPEQVWVSETEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6L8</accession>
    <name>A0A9P4U6L8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_505085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6L8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2438142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="516" mass="59165" checksum="377BA43FECF1918D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U795</accession>
    <name>A0A9P4U795_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_85910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U795"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="86" mass="9408" checksum="C3EEA8F48F83B9EA" modified="2023-09-13" version="1">MVGILATAVARLTGEVFCQHYKLCRSLPRPLGASPCRLQPLSRWASGSGGIFSVMYTICPLHGSFSAYAYSLCVLCSLRTCRYCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8E1</accession>
    <name>A0A9P4U8E1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_419273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8E1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000045">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2441125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="530" mass="57068" checksum="7691C0077739D7FE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8R1</accession>
    <name>A0A9P4U8R1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_524121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8R1"/>
    <dbReference type="OrthoDB" id="3773917at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="539" mass="60186" checksum="543B05932E89DF52" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U904</accession>
    <name>A0A9P4U904_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_464599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U904"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF6">
        <property type="entry name" value="SECRETED THAUMATIN-LIKE PROTEIN CALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="170" mass="18636" checksum="82EDA74F8460243A" modified="2023-09-13" version="1">MVQIALVAGLGKLTVANRCSRDMFVWSGSSRAIKINARSRYTEPIRMSCNGCGVTIKVSRTPQLLGGHHSQFEYAISNNVMYYDISFVDCAKDKDASNCPGHVAGMEIYSPNEKRCDMVTCLGNSYCPTKAYYVDQPKQKLGIPEPVYGCGTAGTDADLVFVLCQNQRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U999</accession>
    <name>A0A9P4U999_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U999"/>
    <dbReference type="OrthoDB" id="3794564at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="113" mass="12667" checksum="C943A973939A9A43" modified="2023-09-13" version="1">MPPRNRSTRRRKPRATKPAKPAKKTNFDVALEAIRAELKRDYVLYEEALSGVMQAKAAGGDATPWLNQMSDLVRGKPFAAISHEGVKFLVEEMVRKFVADGYQVPQPALMVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9F0</accession>
    <name>A0A9P4U9F0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_61539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9F0"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF242">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="8">
        <location>
            <begin position="111"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2442115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="321" mass="34736" checksum="1AC50E2F1A233FE0" modified="2023-09-13" version="1">MPKQNQSQSAVPSSRKANKTGKLELVSTPTHVSPGISNIPLQSSTQFIALSFTLLTVPLLLQALYTSYLAPIRISLAPENDLNTSIDPSSPSLLAACRAHTYTTQIVSLDPLLIYINNFTSAAEAEALIELGSANFEDSFISRSGGANQKVSGRTSQSAPLAVETPLVACIVARARTFLGTMLHTHEPFSTPQLVRYLPSQRYDLHTDFWPRHQRLSDGSGGLFNRPASFFVFLRDNCTEGYTWFPSVTVEEGKEVGFEGRVERGKEDGGGGDGDGRGVRFKPVMGNALFWVNIPDSGKGDRRVLHAGLPVGAGEKIGMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9G7</accession>
    <name>A0A9P4U9G7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_475616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9G7"/>
    <dbReference type="OrthoDB" id="5386682at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="241"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="862" mass="97831" checksum="1559CEE2355E1A8D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9H6</accession>
    <name>A0A9P4U9H6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_487445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9H6"/>
    <dbReference type="OrthoDB" id="3352776at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17269" checksum="3741D8B25F34AE30" modified="2023-09-13" version="1">MSSGQQQKQKPSAAVLRKGAHAFCAALLSPPAPSDLLQTYFTAAPSITEHGPRWAASRLPFLGKTFQGRDGCEEYFGLLGEVLEMQLPEDALPGSQGFIVDAEAGMVSVVGKGHFKSKKTGKGWDEQFIYRLSDFDAEGRVGHWEIWADPLSAWDAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9J1</accession>
    <name>A0A9P4U9J1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_432740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9J1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2443494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="344" mass="37904" checksum="753B014461F9DAE1" modified="2023-09-13" version="1">MSRFSRIKGPRPLYICAAAGAGVAAYRFLKPESLNASLHPHDFAPYILVDKQSVSSTNAIFTLHDGFGVPEPDSVKEARRRGVWSVQAKQPQLQIARAYTPLPSKPNESDDEDGHSLRFLIRQETGGEMSTYLHRLLAGSTIELRGPTVEYELPPDVNEVLFLAGGTGIAPAMQVAEALSRSTGSRMHLLWANRRREECEGGFGDEALFDTSGQQPSWWRNLLGLGQDSNQALPVGTQKVVSKGLIVRELEALKERGQSATRGLHVQYYVDDERSFIKPGDVAKRIHTESSEGQGSRLILISGPDGFVEYWAGKKLWVDGREVQGPLGGVLANMDLKNWQVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9R7</accession>
    <name>A0A9P4U9R7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_433925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9R7"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF168">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="32"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2442430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="340" mass="37130" checksum="2B92A5725EDF3A09" modified="2023-09-13" version="1">MQDIYTSLMAHNGAAIIVGTLFVVLTTIAVVLRLITNWSTKAKYGWGEACLIIAQALYYAQYAVQMHGIIEGRKMKSMMDPHLTTYLRAVYIGGEFYFPQIFFTNMSILFLYRRLFPVQSFKRCTTILMAAHGLWVIPAIVAETAMCSPPSVLWEAPLLIPEKCFFYSSFFITVCSVELFLDICVLALPLFYVSRLKLAWTRKAELMFIFLLGGLVVITGIIRIIKSAEAGVQAIDFVLDILWLDVHAGIAILCACLPTYRPLIVKSAAFLSSQGSKLFSSRGSSAANSSGKSGNSGSTGSKALSDGTIGSGGGGYKKYEKFGSVDEVQLVGLPSGPDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAR4</accession>
    <name>A0A9P4UAR4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_389803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAR4"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF5">
        <property type="entry name" value="GENERAL AMIDASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="85"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="238"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="544" mass="59628" checksum="B9BE457E1236344E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB40</accession>
    <name>A0A9P4UB40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB40"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="170" mass="19421" checksum="8FA1566242BC019E" modified="2023-09-13" version="1">MQEEEKKEREVQRIYCKCKRISGRELDGYTYIGKTIIITTHRGTFTTSSPAQPNAHLPAEATKHKINNIHCSYAFPTQALIYFAPAPWTSSKRSSRPSFKLFKYKPCLFHRLITHVRTAYKPPNHAPSSNLQPPPPRLANPSRSTHNPPTINDLSLCSRSLSYWILPPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB60</accession>
    <name>A0A9P4UB60_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_486949</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB60"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="RNase H type-1" evidence="10">
        <location>
            <begin position="56"/>
            <end position="212"/>
        </location>
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        <location>
            <begin position="265"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1149"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="683"/>
            <end position="811"/>
        </location>
    </feature>
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        <location>
            <begin position="1155"/>
            <end position="1183"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2442988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1183" mass="131400" checksum="3C6BA16449A2616D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC50</accession>
    <name>A0A9P4UC50_9PLEO</name>
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        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_387441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444860.1"/>
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    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="676"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2444860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="85868" checksum="2D7451889781EDD3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCI0</accession>
    <name>A0A9P4UCI0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_413338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCI0"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040249014" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="115"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2445205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="248" mass="26865" checksum="7DE4EABB04D09C49" modified="2023-09-13" version="1">MLHYLFVLGFLARYVACGTTPLLQWDPDTVADCAGWYDNAETFSCEYIRKLYGITPEEFHSWNPSVSLDCEPWSFQSYCIITQEKIDALPSTTTLATITPTTTSAAVSLAPSPTAWEAMGCYTEDAEMPILEQNMNPKGDASLTVAKCKNTCYRLAYQFAGVQQGNQCWCSSYVGGEWTSNQKDCNVPCTGDQNTICGGKGLLNVFKALSNSIPASTTTIASIKVPETTTVPASIVATGAAARNVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD52</accession>
    <name>A0A9P4UD52_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleolar protein NOP52 variant</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_407614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD52"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2447454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27971" checksum="C65529243F05404F" modified="2023-09-13" version="1">MAEDAQSSPFMKHLASSDKDTRDSALASLRAFLSSRSEISELDLLKLWKGLFYCLWMQDKPAQQQALSRSLASLPSSLKPPVVLPFLRAFWATIAREWTNIEALRLDKYLYLIRQYVNASFRYLSQNGWGNAEGLQRHGEIMAEFPLNAQDTKIPNGLRFHVLDVWVDELEKVDGEWGVEKREVLEALCGPVEALAKEGRLKVVRNAAKETLGDGRLRVWRGQEEEGEKGDAEMEDDDEEWGGIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD91</accession>
    <name>A0A9P4UD91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_443873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD91"/>
    <dbReference type="OrthoDB" id="3759583at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040219493" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="105" mass="11393" checksum="4C150332F9323F4E" modified="2023-09-13" version="1">MHFTTTFFTLLLATLASTTAIPDANANPSNDIIARFPSDLVSSATTALVDRSNELAARDCNCGREFSCSKSVTECCKSTGGYGMCKTDIHRCKCGTRCNPLQCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDJ9</accession>
    <name>A0A9P4UDJ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_385317</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDJ9"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="793" mass="88854" checksum="406256689F4018DD" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF65</accession>
    <name>A0A9P4UF65_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_232230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF65"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="607" mass="67772" checksum="0782691A982EEEC4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFA6</accession>
    <name>A0A9P4UFA6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_481386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFA6"/>
    <dbReference type="OrthoDB" id="3140657at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="14091" checksum="83F226600B552C10" modified="2023-09-13" version="1">MFNNDLCTCWLRPLQGRLTHLSIYTTKLLWGFWTYCDIRAVQFPYLKSLRLRDQTIVHEWQVEWMLVRPATLEQLLLDDCPIFTVMHLDEEQIAMHFPGLTLIYISEGRGIYTKELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFK8</accession>
    <name>A0A9P4UFK8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_250173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFK8"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2447352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123028" checksum="87A8EBEAE42C9445" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGM3</accession>
    <name>A0A9P4UGM3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">P171DRAFT_427534</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGM3"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="22">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF2449330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="151" mass="17112" checksum="891027D59C979CA6" modified="2023-09-13" version="1">MSTAARRRLMRDFKRMQTDPPAGVSASPIADNVMTWNAVIIGPADTPFEDGTFRLVMHFEEAYPNKPPGVKFISQMFHPNVYGTGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNTSSPANVEASNLYKDNRREYTKRVRETVEKSWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGZ4</accession>
    <name>A0A9P4UGZ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_517679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGZ4"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2450111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="506" mass="56284" checksum="FAD4F6B44F64B1DE" modified="2023-09-13" version="1">MASNTLGTEHDQLDAKNGLEVTASKSSSDGNNPVPLEGQTEHLPTFEHEKRLAFKFDIRILPMLAVMYLFNALDKGNLGNAKTNKMDVDLHFKPGQYNTMLSIFFVPYVLFAPPIAMLGKRIGPHRMLPILMTCFGAMTLLSATTRNWSGMMALRWFLGMAEAAFFPLVIYYLTTFYRRGELARRLALFYAASNIANAFSGLLAFGVFHIKHSKLEAWRYLFIIEGAATIIVAGFAYWWLPKSAYEAKFLTEEERKLAFTRIQIDSSAIVGEKFVLKDALQIFKLPSTYGFLAIEICLGVPLQSVGLFMPQIINALESDVVQVNLKTVAPNCVGAAVLLILAFASDFTRIRFPFIALGFALTFCGFIIFAAIDVPHHLSVAYFGAFMMVWGTSAPSVLLSTWYNNNIAHEGRRVTLTSVGIPLANLMGVVSSNIFRDEDRPKYTPALATTAAFGATGCCIALLLGTYMIFDNRRRNKNQGVNLTARDVSTEKLREGPNSPDFRWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH01</accession>
    <name>A0A9P4UH01_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_429018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH01"/>
    <dbReference type="OrthoDB" id="3694677at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040452819" evidence="2">
        <location>
            <begin position="24"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="404" mass="43909" checksum="5BA8CCC48563967C" modified="2023-09-13" version="1">MNLKLLDTILLGLLATQAPLVDSRSIPSSVRCLEPDSPGPCLNQSIPPVFRVPIHPAVIDNDLHKRAGGRPKAKPKVQVGSGGGNRSGGGTTEGQRAGTVGNKDESQAKSGGSSDPQGGGKVHGTTSGSQGGGKTSGSQEGPPSKRNNDNKPAQTPEKMDTKGIKLDEEELRNMFKKRIRDNGLEDAENYFFYTGTFPIEAVEHLRPLYSMRLKDPEGSLGAPTQEDVDYAKKHLPAMNDIRAQPKSQINPSIKPIVTDKDLLGMDYYWAANSKAYAQIAKGNAILAIRLERNINQAGYNERGTFWWTWEIAELTRNPNIDNIKIIPIDSKYGASKDGRPDPIAVGKPMTVWSKGDPPLSFPADLEHVMARPGEGLSYDEVFEVNTIARAPPEWEQIKGTFGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI88</accession>
    <name>A0A9P4UI88_9PLEO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">P171DRAFT_335375</name>
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    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450052.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
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    </dbReference>
    <dbReference type="GO" id="GO:0005815">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="149" mass="16151" checksum="07814C039A0360E1" modified="2023-09-13" version="1" fragment="single">TTPVIELVSPPHAYNPSPAGKTALLHLLITHAILPSTLSTVLLSGLTSAIILFDPLHHFSISFLATTLLSHIISCFTAAGKDATTDTAKKEITLCVKQALNHVHIFRPASWHSLLATLRGMESYLFDATQHSSTHRPIHALILDDVDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJD5</accession>
    <name>A0A9P4UJD5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_492993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
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                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="774" mass="84959" checksum="E3ED71A0E52E57C9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJK7</accession>
    <name>A0A9P4UJK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_5840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJK7"/>
    <dbReference type="OrthoDB" id="3794829at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
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        </location>
    </feature>
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        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="229" mass="24759" checksum="9F1AFEEB48735262" modified="2023-09-13" version="1">MCKYFKKVFTCGHLSQVYVERCPAACKPGTEACTTHDSSHDAEQFASQLRQEARRSHFECFGCLEGKAAAESEAAVAAEQDPQKRAEMADKHGRLASKAAKADANRKTAEQKMKAEREADAAAAEALKAEKERAARGDGVWIESGSARKKKGKHGRGFHDPRSPAQSAPPTPTFRMGVDAGVGGRAGKMGEFRNEPRSANEVDAASGVGAWPKKILSKGEGQRENWGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJL2</accession>
    <name>A0A9P4UJL2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hamartin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_450329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 690.94</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
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                <person name="Goodwin S."/>
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                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 690.94</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="904"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="953" mass="105236" checksum="AFE2036135304ECF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P644</accession>
    <name>A0A9P4P644_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_372699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P644"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040491487" description="Hemerythrin-like domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="293" mass="33106" checksum="D56BF6ED2C09096B" modified="2023-09-13" version="1">MSSYSTALFFALQVLLTAFLLSRAPSDMTPSPSAQWADGPCLLIKTPQYKTKKTDVFTVGATHMAHIHNSILRGYNSIYHQAPLISHEDKNDFIGYALAWCKFVQSHHDSEETELFPSVEDALGRKDLFAETHKEHEAFLAGLTRFGEYLNTLGEPYDFDGEELQKIMQSFQEPFNYHFHHEIETIASFADLPEAHKAEDAAAVFKAWGKKTVSKAGTADVVPFFLLNHDVTYEEGMWASWPPMPAPVRWGLVNLAGAWHWAWWKFASCDAGGRPRELWALAQPRRPEKGSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6B7</accession>
    <name>A0A9P4P6B7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_477653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6B7"/>
    <dbReference type="OrthoDB" id="5342093at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="25"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="286" mass="32749" checksum="25C77721CFA3BA9D" modified="2023-09-13" version="1">MIEKAEPAAPTFRDQWKWQDSPIGYPKLAERIAVLPETGIYRRFDALNARNLLYLQSELCTLENAIREQEERDQHDKRGNKSKYATDHACMLNDAPSVGRRQLNLVETLRKKISQYNKALIQQSKLQRIHPPDRFDLSNVQAFLQSEHMKNDLVGEDSETWGNPRDPDNHPPDLIGIKPRRKEDTFSRLVAENAVHLFKCGLGRFTKKDRHLGRKVYYDTHVMKATVVMTSILASLIPIASIWVLVSLHSLKHKMIAIAAFNVLISTCLTFFTDARRTDVFAVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6C8</accession>
    <name>A0A9P4P6C8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial carrier protein pet8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_437145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6C8"/>
    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11023" checksum="DB2BD2E821D5E7CD" modified="2023-09-13" version="1" fragment="single">MPLRVPTARLTPRLYRRTFSTTPRAFLNEVGNRSGEQLEQKKQEQLKKQEKGEGHWHEELASQSEAKMAADKEHVEDHDKHMGETAKKGEKGELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6J7</accession>
    <name>A0A9P4P6J7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_437699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6J7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="150" mass="16939" checksum="50B1463F516789DF" modified="2023-09-13" version="1">MSVSTLGYMAHQPNQLRHALMLSANRTRRGTSSRHIHGDRGGRNTCKSRLQQCEMKLFSIEDMPTLPVCACTLENTKTCCRQRTVVTASALVRLRLPIPRAWEPLHATSSHQAPLPTRIFRFNMELARLLTNLANLGHSKRTSFDTHFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7B8</accession>
    <name>A0A9P4P7B8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_110098</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7B8"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040139329" evidence="12">
        <location>
            <begin position="27"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2439735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="381" mass="42933" checksum="97655D2D9C55F493" modified="2023-09-13" version="1">MLSFKKALVLSLAVLTLFFLFKSTHSSAAPASYRNANDMPKPTSMQKPKPAPKPETKPDAAKTDKAFDAPGTPKKVREQIPLDVLHKKPLRKQLEYQFPYDVDSKFPAYIWQTWKTTPAQGNFPEEFREAEASWTVNHPTFVHEVITDDVAVHLIRHLYASVPQVLEAYNALPVAVLKADFFRYLILLARGGIYSDIDTHALKSAADWIPSDVPSDSYGMVIGIEADPDRPDWADWYARRIQFCQWTIQSKPGHPILVDVVANITQETLQRKAEGKLSKDPKGIIEFTGPGLWTDSVFSFFNDPAYFDMSTSKGNITYTHFTGMKQPKKVGDVIILPITSFSPGIKTMNAGEEDDPMAFVKHQFEGSWKPESERHIGKIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7L0</accession>
    <name>A0A9P4P7L0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_476814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7L0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="162" mass="18325" checksum="B9CEBA23B0D22AB9" modified="2023-09-13" version="1">MKTTLLTTNDTKYQLCNRMPTARQRNRGIDRTTKQSSHPTSKHKSADGRAHVALAKATPKRRADSNCALSKALQLNWSVKSAATWANIFDWQRMEVELEAAASRSGDSGDHAVHLTYQKMGSIPLRSDRTYASDFTVPMNLRPEEQIKWAIKKATKPEKAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7N1</accession>
    <name>A0A9P4P7N1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_500734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7N1"/>
    <dbReference type="OrthoDB" id="3729777at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="227" mass="26197" checksum="E42C7B9FEDFBB0DD" modified="2023-09-13" version="1">MSKLLGVWGEVPEENQEWHENTQIPEATKRLRTRAFHFQAGENMFPEENAQTATSFTLYDPLESAESQLSTEQSLPPAGSSSDALNDVLLQARFHTCEFEDKAEAFSGVPDYADVGCLVMGCFQPTPEMHDAFFEWWRGEFVPFIQRSPEFQRVRLWKLDEAADLRNRTVQKRDREDLLQYVMVYEFQSYDMPWEVAVEIGQSKAYQDFVEKDLVCLSVAVRNFGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7P5</accession>
    <name>A0A9P4P7P5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_424102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7P5"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="471" mass="51914" checksum="6F0B6D94939F5C49" modified="2023-09-13" version="1">MTDRVTKPRPRKKREVKTKSEKEASPIDGVLLKTEPATPDSPSIVSALPVATPPSRKTPVAVDQVQRSELATKDAIAQIKRHYRLPALYQPSKAVSDALDVAFISHFVKQNNTTRRYTPEVPWITSLPNLRGVATKPAVRLSIRAASMAFYAAVHRDTTVLVDSYRWYTMSLHSQRQSLARLGANCVPDDEEILVPIILSIYEAYAGTTTTSMWPHMAAAAKIIELRGPTNCTGVTATLFRIMRVSDAHKAIVFNTPSAFASPEWLTTPFIGQAKSAHQEIADIMLHIPDTIAMLEVMPGSLRRFFNQPLPFGAVVEPVAARIRTWLRFLDDWAARFPYFTKAPTKEVIITTDMINFSSGVHMTPLPTPVSVTAPPYPSPPSASSPTLLRNDEASFLDAATTAARNVLDIAKYQETTHQIGGFDVLRTVFPLVIVGNLGPRQEEKVRAVAVLTKWGEQRGIAGLCTAWLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7X0</accession>
    <name>A0A9P4P7X0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_117400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7X0"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="38801" checksum="48C2B5148A4CCC06" modified="2023-09-13" version="1">MALHVENPCLPPGALILVTAGNGYLGSHIVDQCLAYGYSVRTTVRSLERSAWMKRDFSKRHPNGQLEVVEVSDLSEPGCYDAALKGVSAMIHTPGFTNMSDPDMVGNTVKLNMIALKGVHQANKSGEKIQRFVLTGSSWAVKYPVPNVPGDIAEDQYDESIAKALSNPDTPKDFWALMGYVQSKIAGEQACWKYVRQHSDCGFVLNTVIPATCMGPVIAPAEQQYPSTAGFIRSLHECQGQELFDVIEPQWYVDVRDQARLHVAGAVLDGVENRRIFAWAGPYTWIGVADVLEEEMGKRTTIRLADKGKDMTKVLAKDKAESYLKRLDRPDWVPFDQAVSECIRSYYPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7X1</accession>
    <name>A0A9P4P7X1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA synthetase/AMP-acid ligase-like protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_397347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7X1"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="47"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="502"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2439035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="598" mass="64904" checksum="A6C5B20A3EEFFE98" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P809</accession>
    <name>A0A9P4P809_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_370799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P809"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="112" mass="12680" checksum="A9B92ECD1250F81B" modified="2023-09-13" version="1">MLYEMIGVVRPGRLSEVKEIAKTAGKIVLEKNGVVRGVTNWGTFLLPKPAKKLQSSHNVGHHFIMRFDASARTQHSLRRTMSLDPRLIRYSIVKMGTKFEEIKDIAGQASFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P816</accession>
    <name>A0A9P4P816_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_170473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P816"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2438239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="458" mass="51544" checksum="78156B82CB635F82" modified="2023-09-13" version="1">MHHPSGSIKGLFSGIMSLGSFVALPVIPYIADGMGRRWGICIGSIIMILAVVLQSASVNFQMFVAARFFLGLGVAIAHGSAPLLITELCHPQHRAIFTTVYNTTWYFGSIVAAWLTYGTNNIGNEWSWRIPSIIQAAPSILQITCVWFVPESPRWYISKGQNEKALSVLAHVHAEGDANDEVVQLEYEEIRETITIEKEAEQTGWLEIFKTKGNRHRFIILISAGFFSQWSGNGLVSYYISGVLDTIGITEQDMQLKINGVLNIWNCVVALTMCFFVDKIGRRPLFLVSTAGMCMSFVIWTILSERFDATHVKANGSAVVFMIFLYYTFYNIAWSGLLVGYTVEILPYSIRAKAMCYMFACVDLALFFNTYINPIALDDIKWKYYIVYCVWLAFELVVVYFFYIETKNTPLEEIARHFDGDAALVGGNAATEKGRIIERDIHEREKTASVTEERVGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P825</accession>
    <name>A0A9P4P825_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_467401</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P825"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF480">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="155"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="337"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2438254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="436" mass="49352" checksum="518E0EB4A0F38CC6" modified="2023-09-13" version="1">MTVVRAIIGFTVAVSVLTFIAFFGRTPAFRNTPIGFCHRLLVHRIPSALRALDVFLTNGRITSGGSRLGHHLMNEKHPVVMIFFLGLITVSASLLVPTVWNLLPFHHKLLVAILLPQPYYFTYLCAKRNPETVVTEMNHAAHMRHYPYDRILFYPGNVCRTCKFNKPARSKHCSVCKACVSRADHHCVWVNNCLGRGNHKWFLTLLLSTAILLAYGAYLAYFALSPKVHKQYARYESWYRFKPSPGSNPSSWTTYGEKKLHYFLTYVSIYIDAGGISAAGVGLLALLTWPLPLGLLIYHLYLIYAGMTTNESSKWADWADEIADGKVFLGKRKPETMRDYRPRGADLHDSTQSSSATPIPTPPETPPEEEEPPTTWPLESRHILVRTTNGQPPTKLPPRIKSVADKESFERVWDLAAVENVYDLGFWDTLLEILLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8J3</accession>
    <name>A0A9P4P8J3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_133441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8J3"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="948"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="976"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1139"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2439197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1213" mass="133581" checksum="EFCC0B53C64E42A4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8W2</accession>
    <name>A0A9P4P8W2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_422537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8W2"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2439003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="68" mass="8196" checksum="F7F5F29DBA6DCEDD" modified="2023-09-13" version="1">MAGWIYRENRVPSYQREYQKHDGIRLWMKSRGKWMIPAYKAVLYTSIGSSMYMMGRLVFGHKTWFGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9T6</accession>
    <name>A0A9P4P9T6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-mandelate dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_396314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9T6"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000526">
        <property type="entry name" value="D-mandelate dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="101"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="187"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2440131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="376" mass="41035" checksum="178A96E609CA6347" modified="2023-09-13" version="1">MSSATPTPRDTGLPAPTTATPSSLPAPPSPTPTPKPTILHLGDDIRWNHALYEELGAKFHIERTYSMGREDFKAALRDRRWGDFVGMYRPFWNTGGEMGNWDEELITLLPSSCRIYASAGAGFDWVDTRTLATHGIVYCNAASACTESVADTAIFLLLSTYRAFPWSFLAARSCDPTAFHAANQHIAAVTHNPNHTTLGIIGLGKIGFRLAQKAMAAFEMEIAYHDVVRLEAREKELGHVRWCGELEALLAVSDCVVLATPFEGRAVLGRQEFALFKRGARLINIARGKLVDEEALGEALDSGIISAAGLDVHSDEPNVNPKLARRDNVMVLSHTAGASVESHVGFERLGMENLISFLGGGKALTPVNLEWLVRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9U0</accession>
    <name>A0A9P4P9U0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_489759</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9U0"/>
    <dbReference type="OrthoDB" id="2341546at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="647"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2439982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="738" mass="83559" checksum="7E9B0CB03904F83C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA90</accession>
    <name>A0A9P4PA90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_109603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA90"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040105849" evidence="1">
        <location>
            <begin position="23"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="2">
        <location>
            <begin position="93"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="583" mass="65110" checksum="317E9CDF85858FEF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAL5</accession>
    <name>A0A9P4PAL5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_394818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAL5"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040430949" evidence="1">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="96"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="442" mass="47806" checksum="495036FADD1BF2EF" modified="2023-09-13" version="1">MAAFTSLGVVLLAGFVAANTCSNFSIPVEISSRQGVFPNIPAEANLEVTSFAQQFSQQGRNYSAKILQGYATVQGKYEISAKYCQPDNGKASTIQILSHGIGFDKTYWDLSYNNYNYSYVKVANAAGYSTLAIDRLGIGNSSHGDPINEIQAQLEVEALNAVTTLLRARKIPQVKNHYSKVIHVGHSFGSIQSYWLSALYPNNTDGLVLTGYSGNGTFLPSQTVPAWNLHSARLNQPLRFADAPNSTLRAKFNGWLKNISLVQALQTLLKGVGIVVSTDDIWNDIATTEVGNIINGWNVTNEQQLNYPSGYLTHSDLTANQFVFLRYGAYDIGLGVVTEQTKQPVTIGELLTAGSAPSETSFSGPVIIFTGEYDEPFCGLDCYPTGGVAPNIPVQAKKAFPNAQAFEAYIQPNTGHGINAHYNSTAGNEYVQKWLATNGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAP3</accession>
    <name>A0A9P4PAP3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_102069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAP3"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178">
        <property type="entry name" value="SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178:SF0">
        <property type="entry name" value="SERGLYCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="576"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2440505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="840" mass="88833" checksum="B5A12366BA50F333" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAT5</accession>
    <name>A0A9P4PAT5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_434249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAT5"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="707"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="742"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="867"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2441594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="104468" checksum="4569C32D5AE1357D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAZ6</accession>
    <name>A0A9P4PAZ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_369462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAZ6"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018455">
        <property type="term" value="F:alcohol dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="9"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2440098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="338" mass="36857" checksum="59BD5DF860CBC9D6" modified="2023-09-13" version="1">MKAGQWDPKSKKVVINDIPQPTPNDNQFLVKIQSASLCHSDLHMDMRPDHPVTLGHEGVGYIESIGKNAEGKGFKVGDAIGTNYFIDCCFECEGCLVHNLRCETGKSRLQGFVADGFFAEYVVVDWQNAVLLPKELDISKAAPLFCAGITSFHSVDSCELKAGQWFAVIGCGGLGQYAIQYAKAMGYKVIGLDISDLQLEMATKVGADAVFNSMTNKNYVAEVKKLTDGKGCHAAAVYSASNAAYAGAPDVLRVGGLIMVIGIAPKPLDFITTFDLATGRYRIKADSMSIPQRMKKAVEFTGKHTIQPDVEFNKIEDLPRMVEDMEKGKADKRQVVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBQ9</accession>
    <name>A0A9P4PBQ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_465678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBQ9"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="439"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="744" mass="82907" checksum="2B92A745377916EF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBR3</accession>
    <name>A0A9P4PBR3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBR3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040321180" evidence="1">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="89" mass="8718" checksum="863A8CEFBF1CDDE7" modified="2023-09-13" version="1">MQFSIIIAAFAAAASAQYSNGTSVVAPSGTAAPSGTGSAAPSSTAPFEGAAIANGPAMAVLIGAGAVALFHHCFHQRDNNNTSTSAFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC87</accession>
    <name>A0A9P4PC87_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_447328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC87"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="367" mass="41549" checksum="886F9CAC0B95BB26" modified="2023-09-13" version="1">MSALAANNEPSETASTIFHHHGQGKQNSQVGDGAQYNFSNHAASGSHQYSGVHQSWTGTANNGTGGPYYVAGTRSTSNVINISTWNNLFYIGNQLPRELVVPALSVRKSESPVIPPVGSVTFDPGNGSQDWALGRASRSEDVDRPSSVPTPNMHTTSDTIQCTTELFTSLGKTEHYLKPNKHYWRRLTLKSYFVYKDIYRSCSKVDARNGLEDGLVTFRTYRLHIPSQCDDDKLRKVWRSVSCNEHTPAEDIVHTRALVLAVTYMLHISRFSANLPDYDSRNTWTIEDRRLRRVELYDRWIPCHCGTECTRWWCFANDNGMSNPTAENPPKCPVVELLNGARDRSLDRYERMVEDMRTEWARPLIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCE4</accession>
    <name>A0A9P4PCE4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesteras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_395522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCE4"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000054">
        <property type="entry name" value="DCR2p Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="220"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="554" mass="62162" checksum="6B29119365024CCB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDG3</accession>
    <name>A0A9P4PDG3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FMN-dependent alpha-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_434511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDG3"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="341"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="364"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="428" mass="47325" checksum="126206007C8FBBAE" modified="2023-09-13" version="1">MDPNNPNRESRSTPQYALYQRENFWKSNDGQVPPFNTDPGELERLAQQKLTQNGWFYASSNAGQSHTHTTNRQSFYRHRIIPRMLVDTNTRDTAHTIWSHSVSAPIGFAPVGINKIYNEAGELPVARVAGELNLPYCLSTAGSQPIEDVGVANDALAKDGKGVRFFQLYMPHDDALTRSLLQRAVASGFTACILTLDTWQLGWRHDDVATSNYAFYHGKGADLGLSDPVFQQRLREAGIDPATQPNEAGALWIDSVWHGRAHTWEKAVWAMRLWKELSGGKPFALKGIQSVGDARKAVEMGFDGIVVSNHAGRQVDGAVASLDALEKIVDAVGDKIYIMYDSGVRSASDVFKALALGAQFVFVGRLWIWGLSIMGEAGVRHVMKSLLADFDILLNVGGYRNVGKIIRNRAALESGPRDYPLQPRTFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDJ6</accession>
    <name>A0A9P4PDJ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_363435</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDJ6"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04105">
        <property type="entry name" value="SR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2443064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="293" mass="31669" checksum="3A8E62CCE108F2B6" modified="2023-09-13" version="1">MAWYDEDSWATAAFAPKGSTIAATFLLAVLLPILLHQFIYRKVTPTSLPSFLLIGPSGGGKTAFLTLTERKAVAQTHTSTAPLAVEVLLPEDHTPQSSHYRSLGDPAYERSRRFQLNDTPGHGKLRQFATNQLANPTNVRGIIFIVDAASVAEEAGLNESAEYLHDVLLALQKRYTGATTSKGPKEIPVLIAANKLDLFTALPPHLVAQQLEKAISDVRKSRAKGLKDSGPALDGEDDSLDEEREWLGEGGEGSFEFAQMEEVGITVTVQGGNVIGGDGADVKSWYEWIAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDL1</accession>
    <name>A0A9P4PDL1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_434119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDL1"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="56"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="255"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="110073" checksum="201AFFA27B25A2C3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDL5</accession>
    <name>A0A9P4PDL5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_60569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDL5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="174" mass="18967" checksum="9DA8C78E17495BE3" modified="2023-09-13" version="1">MSWGDSNPHASANSPPCPRWYHVGAWPDVKVVGASRCPPQAKHQLLSLRRRGNRKAAPTRKNAYTSGAAPLERPLILRADGCIGPPFTTAPTRTYSPSSVRPTYRLPYGSVSTARWTRSPAPPPEPRQPLRRRLTGALIQSSASRTAQQCAASDTCNYELCALSLLLFSPLNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEA4</accession>
    <name>A0A9P4PEA4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_392780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEA4"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="347" mass="40176" checksum="348BA76AF3D65150" modified="2023-09-13" version="1">MHSLVGASSMASLFRIGQILKGRLGKYTVTTEIQDTVWFAKNQLHENVVIKSVRDHPRVENERDVLKRFQHRTPHLRPLIDEIEEPSQPTTVVLKYLDSDLWQTAQSERKQLNRKELKHVSRAILEALRVLHESGYVHTDVKPSNVFVDLREGDVRFGEVQLGDLGGCCSVDSWYATTGAFAGTTVYSSPEAIMNMRWNTASDIWSFGVLLIGLIYGGNLQIFHPTEPDPNHEEYRVEVLKEQLRFFFPFPEKFKEITSPDTVRSILYLMQQVPAYTPFSRTTDTEISRVDRDFVCKIMKLDWRDRPTVKELLEDEWWNVDEEPVLLLHPKSFPVDQPQHTEVQQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFP0</accession>
    <name>A0A9P4PFP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_433401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFP0"/>
    <dbReference type="OrthoDB" id="5232280at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="68" mass="7919" checksum="D8A026AB163BE4BC" modified="2023-09-13" version="1">MGGLSVSAPEPWTVQSFFMRYYHDLFFRIVDTSSVAFQTVEGEWGFRSHKLLHHIRTSGINYGPIKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFR7</accession>
    <name>A0A9P4PFR7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_55875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFR7"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2443097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="175" mass="19580" checksum="14AC6E6F4ED79A41" modified="2023-09-13" version="1">MHRATMAEQTLNIPQIIVFIAVTVLIVRWFLKPSPIDHLVQMFPQLDRRTVAWNLNRTGGNAQVITEALLAGGTLQQPPASFQLPPSRTATPSAGQRQAPRQPAKPTQPDLITRYNLASKVGQAAESTAVETPKTKAWSQDKNERQANLQRRREEMILAARRKLEEKAKAEQKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHT6</accession>
    <name>A0A9P4PHT6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_521310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHT6"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="314" mass="34278" checksum="951F3A2E6ED3B9FD" modified="2023-09-13" version="1">MNGKTVFVVGGSSGLGKEISKVLASQGAHVTIFARKQELLDEAKDEIIAVRATESQRFKAVASDMSHAATAHSTLAAQRELPDTLYCVAGGTANELGYLMDLEPDQIERCMNNNYYSSLYPAQAVLRAWVQDDKSAGVPKSPKARSIVFVNSTASLTPIPGYLAYSAGKSAQRALADTLRLEIQRYSGPISTYSVQCVFAHNFITPTFIEEQRNKPELTKRLEGTTGDLSKIEKGFPYAEKIAPEIVANVAKGDFAIMDGRFEPQACWAVSIGSSPKRGFGIWDTILAVLMAVIFPFIRNGWEKECRGDALKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI32</accession>
    <name>A0A9P4PI32_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_32878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI32"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="173" mass="19483" checksum="82133F840BB3CC58" modified="2023-09-13" version="1">MFEWCWHLSSPSLVTRVGTRLVDAEIDDDRTGEKDAPTHRLGQREAVQLFKQSQLRGFGRDGRRVQRRQRIESVAMLSHVAKLRLVRLGRRSTASHVAPWASLLCACVGSSHACLRPLCADGRGKDEIASHHIHYREGACIILRDGSSRRPRNHAPHPTPAAPMDRLVHMPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJH9</accession>
    <name>A0A9P4PJH9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJH9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="169" mass="18203" checksum="E5A92E8305F5E884" modified="2023-09-13" version="1">MCTQDIYVYSRRAATVVEAARATTSPQITPHTNPATAAARAAPASRPPAAPWAALIQRMLSPHVDAARTAPSRQRPAASSPSVASPSIVRIVRSTYGQSVGQPPSSGHAGREGRSRSRSRERSGAGTGGANSFREDFYADNSASSRSYMQPRRRRDEDEDEDVFGRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJR6</accession>
    <name>A0A9P4PJR6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_455094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJR6"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="446" mass="50264" checksum="4AC878FA01A04981" modified="2023-09-13" version="1">MDVVMGLVAYLPLLAINLLATATALQAGKSFLVPIDHAETEKDCDVHGNNASNMLGLLAMTCIAGLLSALKLRRSYASWPQYIFFALVVALLSSRDLAARYRPRWITMYDAVPSDPSDYSDATYVAPTPEDRKHALLRIMLIAVALPAAWLAYLTLNFSQHIHQKVVELQPILDLTYTPQTNTEIVISMYKEPSDQVAYLVSALRNMDNVGRDAKVHIYVKDMNANIEEIQQVTGANKVTALPNIGREGETYLKHILGNWDTLARETIFLQADVHNPREFYPRVRDYFVPGRTGMLSLGWSGQVCNCDTCGDRFGFRDTTYLFPEISNRINNAAKCDEVLLSYKGQFIASAKRIRGIDKSIYQDLHEAYVKQDSWAHQEEYLQGRPDSMDAPVFGYTMERMWNLIFQCNSMEIAWKCPTLLSGHRIGGNVEDCQCLDPKSDSHTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJW7</accession>
    <name>A0A9P4PJW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_432000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJW7"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="289"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="415"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="78486" checksum="29BC8B1449579EEE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKD7</accession>
    <name>A0A9P4PKD7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_519071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKD7"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="NADAR" evidence="7">
        <location>
            <begin position="272"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="458" mass="51156" checksum="9D7F674FB2415A3D" modified="2023-09-13" version="1">MLPNGGLTNFSSLVIQGLGFDRFGTLLIGMPSSIVSSGSMVVWGLFSIKYGHLRTWGMIIPLLPAIADIAIVYGTMNTDANKYGRVVAYWLINSYAVTWPFLLTIIGQNVAGHTKRAFTNALMLIIFAAGNIAGPFFFRTQDAPHYVLAITTIPVCFSLALFCALGLRLYMIWENRRRERVFGLLQTVNDQVDGMRLEYVEFNNWVSSAVDRKWRSPLELVVYPSGVLPRHCLVDNQNMPKSKRKIVAKSKAPTRSKALPGIQGPSTLDPVFFYKPDTSGEYGFLSPWWYSRFTVKDEVYINAGQFILAEKARAFGDKASKARQRILEESETEVLISLGENIKGLEKSWRRRATRIAQNANIHKFLSDDTESRDLLRQLKNLGERELVFADPSDAVLGIGLSATEATEVDRAQWGANVSGKSIEAIRATKACKDQKASDHRGFDTSIFDVGGRLSIHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLB1</accession>
    <name>A0A9P4PLB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_410100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLB1"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040349901" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="196"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="266"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2446117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="317" mass="33423" checksum="09E5A62B003189B0" modified="2023-09-13" version="1">MRPLNFLSSALLAATTLLEPASALRSNKIKLSQIQSLTLRKDQQTSHRRVSAIPQLKCIGGSARGHYEVDVMRCKNSGADYDDEAIQWTCTASLPEEFKLGSTDVICEGYDSPDDPYILKGSCGVEYRLALTEKGEEKYGHKKPWFGGGDDDGGEHQKTTGDKVVASVFWLIFIGVAAWIVFNAVRNWATGQGGAGAGVGGNRPGWGGGGGGGWGGNDDDPPPPYDWRPGQGQNKRAYGGTENQGWRPGMWSGALGGAAAGYAAGRMGGRSGNQTSGSGWGNSGWNNGEGSSRSSSGSSNYSGTRHESTGFGSTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLB2</accession>
    <name>A0A9P4PLB2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_251378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLB2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="96" mass="10699" checksum="72A83DA87D8F1B1C" modified="2023-09-13" version="1">MKCASEMPGRCFVLFVGVFGASVTTVNRRSYLHTNKPCHFYVQEATLVVAYIHHTSSRLHLYIFGVLRRKSSLVQSSVKIVTQENVNGPHSSGIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLC8</accession>
    <name>A0A9P4PLC8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_409725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLC8"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2447219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="353" mass="39956" checksum="6670ADEAB97BBDFF" modified="2023-09-13" version="1">MALLVDKHRPRSLEALSYHPDLSDRLRSLAQSGDFPHLLVYGPSGAGKKTRIVATLKELYGPGVEKIKIDARVFQTTSNRKLEFNIVASVYHLEITPSDVGNYDRVVVQDLLKEVAQTQQVDLNAKQRFKVVVINEADHLTRDAQAALRRTMEKYSPNLRLILLANSTSNIIAPIRSRTLLVRVAAPTEEEICSVLRVVGKKEGWKEVDGLNKRVAKESGRNLRKALLMYEAVHAQNENITDTTHIPPPDWEALIGQIANQIVEERSPARLLQVRAALYDLLSHCIDPTTILKTLTWKLIPKTDDALKPEVIKWAAFYEHRCKTGSKVIFHLEAFVAKYMRLYESFLMGVDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLC9</accession>
    <name>A0A9P4PLC9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_431739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLC9"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="4">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2444956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="274" mass="30654" checksum="1E4066A15B2BB6AB" modified="2023-09-13" version="1">MASTIRPSLLPQCTSCIRRVTRRGLDQWGQQQQTRNISKAAKEAERNIVVKLREDIPRFGRAGSYVPINPALMRNKWFPARVADYVPALQLKQLKAQDVDMTRDATFGVKITLEEAEEEIEVAQRPRQHYVRPIEIEQLSAERSMELIDTFVPPTIDFARQLIEQEKTDTKRYGASNAADILNAAMSASKPKPLENAIYGSVSTADIVATIKSALAHNDEAARVHLSENDIHFVSGHEEGDTSKVKQLGMFKVEIGVPGAAQPLTRQVRIRAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLH2</accession>
    <name>A0A9P4PLH2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_252888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLH2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="147" mass="16596" checksum="6A157CC56A03A30F" modified="2023-09-13" version="1">MPRRTWTCRIPICMSDRRRDRTRNALSRIVCRGRPLWRCAAGQSHHSASNRGKGAAKLLRQTQSLTARPAGRRWCSHPPPSFRVAWLWHPFCVLRVAYPVSYLLGGIAVTYLAEHRARLASAPASLPRLHRTASYLSPLATRSSMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM65</accession>
    <name>A0A9P4PM65_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_512539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM65"/>
    <dbReference type="OrthoDB" id="3790651at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="187" mass="20206" checksum="2A03C7D364A58BB0" modified="2023-09-13" version="1">MSLKYFSNRANSAGPISCSFARLPAGGAMSIPGCGVDFRWPTGIFLPPAAEYARDIGLPVLEVPNIGEYHPYEGVSLVGGFSPVAPYPPEGTCPKSFLKTPATSSPHTPYNGIFVLCCLLPGLFQTIWHQMAPGEWTEVLGIMVLAQGSPGLQDIAIEEKANKRLYCVDEECQDKIMLWSKASGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN92</accession>
    <name>A0A9P4PN92_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_453784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN92"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="49"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="488"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2446383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="655" mass="70730" checksum="8FA84508BA3BCE98" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PND0</accession>
    <name>A0A9P4PND0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_246360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PND0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="195" mass="22116" checksum="9125F1020619E1F3" modified="2023-09-13" version="1">MRLKSLQHPGLQDKVHVELEADLDRKDSLQVQQRACFSFRSSNSSATSRWSQCSCPKRTVLCRTSTRLHSKNIGCFPARNGLRSNCSANENLPVRTNRDISLHILANRESPTSTSPFIISSGCVKSREKPFLRRMKSLCRRPQCHSAPQVNIGHHCIEALVDAYWSKAGPINICEHPQSMMHSDQFLMAARNMWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNE6</accession>
    <name>A0A9P4PNE6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_380899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNE6"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="468" mass="51756" checksum="8864CC0C7580F6F0" modified="2023-09-13" version="1">MADPENSSSDVATGVEKRDHPTKWYRSTFYNMTILGLCNLSAPGIWGAMNSLGAGGAQSPGLVNAANSLTFCLMVLSCYFSSVLVKYLGIKGALIFGTIGYAPYAAGLYTNNRFGNTWFVLLGAALCGISAGVFWMAEAAIAIAYPEPWNKGKALGYWLTYRLSGQILGGAINLGINADRNEAGKVSYTVYLVFIALQAAGPFVALLLNRPSKVQRKDGKKVELAILKDPWFEIKETTREFFTKNFLLIVLWIGQAVFSEAVFFTYLALWFSVRARALGSFVSGLVAVTCGNLLGWYLDNPRLSLRTRSRTAFTVIVVFQGACWIWVTVLVTRFRHTHPTYDWSSPGFGSAFAVFILLTAAFQINYLFLYFMVTNLAKDEPQVIRYAALLRGTESAWQAISYGITSVTVFAEVGAVYWNFALWGVAVYPAWLVLRRFGGPKEQVQERSGSEERQAETIAYVERNGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNK7</accession>
    <name>A0A9P4PNK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_249491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNK7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="100" mass="11322" checksum="F7C87F544EAF4EE0" modified="2023-09-13" version="1">MGTNAHECAHLRSSPEKLFVMYERLFISLFLIVPRLYVSRSSGRLRCWLRYEASEGGVFLAEELVSISGSGGCWAGNPEGRLCRGAARCLKFGRRLRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNS4</accession>
    <name>A0A9P4PNS4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_470263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNS4"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="470" mass="52770" checksum="E1F3F87F7569ABBF" modified="2023-09-13" version="1">MEVVSTVASLVALTKDIAKVSDRLVRHFRDAPKELVRLRNQSSLVFLELTYLERLTNIELSHNILPAEELQLMHHAIHIENNDITSIHESLCERAKVTVGKPPVSTRLAWALFDRKSVDDVFEQLERVENRLICVMQLASFFQQQGTNDLVLAAKEADVESTNVFRHNYSFVLGAFWNTLLKCQVELTTSNNEYQRAYELYERLPTPSLTGKMVVLVTLSMRRIWGFLPNVSVICGGLNFVNIIPVDSEIVGACQRGDLVAVQTLFSEMEAAPNDMIAERETLVSVAIQSGSTRLIRFLIEAGAPVQSYDSLLQWTSWVNSNPLTEDNFSEQHGGDNLTLLESSSAPKESMGKRCISKDVYGWAVLHRAAAWGTADDVNILLRFGTMQSLRSRRLSWTPLICAVAHKNIETLQALCNPRIERGICEEQDLRGWDLLHIAVGYVNLEAVPYLLEKGVDPEAQAHAHQAMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ74</accession>
    <name>A0A9P4PQ74_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exocyst complex component Sec6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_471405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ74"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000005">
        <property type="entry name" value="Exocyst complex component Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="271"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="923" mass="105856" checksum="EF0558C76BE7C99F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ99</accession>
    <name>A0A9P4PQ99_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_190611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ99"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="192" mass="21803" checksum="8441C9EDA5AFC796" modified="2023-09-13" version="1">MSVQAEDGFLYGVDFSFDQDTPPRVVAQFPPIDPRPPPPLNNILRAIPTQPSRTIRVIVEYFTGGGTKIDLFKPVAHKINKSTSTSLAEIIAQCHGNNENGTAWGFNMTSFNQASLNPQFGPDLNLKWWLPRARIFQDASHRITLYVNCEASMKAIWQPEWAEASKFCHNILLDFVHTMEHMDRWFCPSKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS59</accession>
    <name>A0A9P4PS59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_517138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="7">
        <location>
            <begin position="1122"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="8">
        <location>
            <begin position="1974"/>
            <end position="2546"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="9">
        <location>
            <begin position="3067"/>
            <end position="3172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="839"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1390"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1578"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1731"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1735"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1749"/>
            <end position="1767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2449431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="3198" mass="359206" checksum="A279E13BCC72D2E0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSF4</accession>
    <name>A0A9P4PSF4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_461274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSF4"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000039">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="698"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="855"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="703"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="976" mass="108511" checksum="4F284562C0D8D853" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSL7</accession>
    <name>A0A9P4PSL7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_142494</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSL7"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1054"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1083"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="112"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="201"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="284"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2450594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1172" mass="123854" checksum="4149DB3E7A7C914B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT71</accession>
    <name>A0A9P4PT71_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_503727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT71"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="39"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2450910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="258" mass="28034" checksum="116DCDD90CF82707" modified="2023-09-13" version="1">MAPSEDILVRAERGIQAALAHLPTWMSRFLGYRGKPAAPSPNLIVCIWGFIGAFGGLGIILATFTESQYFTSRHVPAIVASYGASAILCYGAIDVPLAQPRALIFGHFFSGLVGVIIKVIFNYSFPEDGEGFPRLMWLAACLATSIALVVMHLTKTTHPPAGATALLPCVDRNIHALGWYFLPVLLLSSALLLVSALLVNNIQRQYPKFWIAPIPPSPPVQPKDQQSSPPDPEKADSSETPRSPRLLPTEPHNFKNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTC1</accession>
    <name>A0A9P4PTC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_440457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTC1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="151" mass="16774" checksum="D1A028853E4D2370" modified="2023-09-13" version="1">MSTSMSISSPIPPATHHTANSTPTTYPTTPTPRPHTYRHTPAYRLLVSRALTQQLHLPIAPPSPSPSRSLPNHQPNRGEDKDEHVDEKEEEGWVIRDRLVARERVRWGCRVGGVRWEEFVGDVRRLEGGRGVLGRGVYEGEGKGVGGGIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTQ3</accession>
    <name>A0A9P4PTQ3_9PLEO</name>
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        <recommendedName>
            <fullName evidence="4">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">P171DRAFT_405825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="248"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="309"/>
            <end position="604"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="64527" checksum="F3B8A0888D7979D2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTV1</accession>
    <name>A0A9P4PTV1_9PLEO</name>
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        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_478303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR35391:SF5">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    </feature>
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            <end position="165"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="383" mass="42637" checksum="348E086C444EAA1F" modified="2023-09-13" version="1">MVGDQDWQWSEEFQDYYKWKQRDVPGKARYDLIWGRSQLSRDEQRPTFASVPVSSAMADDSANTPNPPTIIGTDNRALPFQLSTLNFPSISEIQEQYQAPQIIQLDPTSRLNNSSPSFLYQRLDQKPPGSEDASFTTGPRTDTPTTSVGTSRSEHDASRYDDDSVRTVSPIDPQAISRINTLNITSEVGFEAIRNPRGYFKKGRVFKVIWPEPRGELGSGATLHTSSSRADTPLQQPILQANSAFDGTPGLDGIAGSTALHVKTRIFVVIRQRALHCLCLPVYTYSQQGTSKTGVKPEDHAPLVKENAEVELHPDEQAGKLRKPIYLILEDTTLQWSSLSRINLSKVQSVEYNLKVKTVGRVSPDCLTDLEALFREAIGLSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4PU76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_438971</name>
    </gene>
    <organism evidence="3 4">
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3692269at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="453"/>
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    <feature type="coiled-coil region" evidence="1">
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            <begin position="507"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="178"/>
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        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="651" mass="72573" checksum="DB0A55502761051A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUC7</accession>
    <name>A0A9P4PUC7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_469258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="193"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="374" mass="41824" checksum="09DACD39762A8183" modified="2023-09-13" version="1">MASISRRLVLLSRRCPSRTPSPYAAPKYTAQWQARPLSSTPARRADENNPGPPKEAAIPGATPSDPIAEATNPDATPPKETAASALKQLVEDLKALDPEVIEDAIRKGKEGINWTNKEMTKDMNDEDWVIEEDDPRKIGFWGEGEAALGKDEDYYGDDLTSLGHGELEQHRELREYARLIAWELPLLSQLARPFEPPTAETPFRFRYTSYLGESHPATNKVVVEFSANDLALAPTQRDKLIKLAGVRFNPDTEIIKMSCEAFDTQAQNKRFLGETITNLLNAAKDSRDTFEDVPFDFRHHKPKFRPEFPQEWIMTPERKKSLLEKRAQGLLLEEQKANTGGLVDGKNIVANSLPAAMAEPEPVMVGGPRSRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUG9</accession>
    <name>A0A9P4PUG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_439081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUG9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="199" mass="22754" checksum="34E1FBB16A43E56A" modified="2023-09-13" version="1">MPSCTVILATYSHPQETMDDITANNSDPRFAILTALGHTADIVSGLIQVMTNYHHFAIQPSPSYVLATGVNAQVFAAILQSGMKILNPVQKELERRKNSYKLALDEAIQNLEERNDDGADIRFKLIEKFMWGEFLVYLVEVYAKTQYVMEITLFNDDTMKETFQKRAEEDPVLQAKITAYRKEHDLPLDPEIWPDEVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUY2</accession>
    <name>A0A9P4PUY2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_516997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUY2"/>
    <dbReference type="OrthoDB" id="3797976at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="290" mass="32629" checksum="5A8F9B5246455BA8" modified="2023-09-13" version="1">MGTRQKRNIQFIVVSDPTNATSTNSPQKAHSHAARIAHARTRLARTAEYNARRSYKADVPVDDKDRYQSKSGSATRLQLQLRSVPSPLRSMSADRRDPFNSSATDLSPIECFLLDHYAQVVVPTLNIQCRNLKDLGESTERMLREWVRLALTDAVILQGILLAACRHLIERGYQVWRFEELAAGYKVRCLRDVIDAIGSEDLDMDVTFARIFTLANDEIWLGNLDMFRRHAAGAIKLVVMHGGPGRLGLNGYLQSLFRIVLDKEEALREESKPCAGLTGGIDRLRDILIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVS9</accession>
    <name>A0A9P4PVS9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-D-xyloside xylohydrolase</fullName>
            <ecNumber evidence="5">3.2.1.177</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_480177</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose.</text>
            <dbReference type="EC" id="3.2.1.177"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.177" evidence="5"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVS9"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061634">
        <property type="term" value="F:alpha-D-xyloside xylohydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06593">
        <property type="entry name" value="GH31_xylosidase_YicI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000053">
        <property type="entry name" value="Alpha-xylosidase YicI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000009">
        <property type="entry name" value="Sugar hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007940">
        <property type="entry name" value="PRK10658.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="8">
        <location>
            <begin position="59"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="281"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="9">
        <location>
            <begin position="616"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00052064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="768" mass="86360" checksum="D9928542CAB6823A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW08</accession>
    <name>A0A9P4PW08_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_402576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW08"/>
    <dbReference type="OrthoDB" id="3784677at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="169" mass="18290" checksum="CA222131E7AEA8AA" modified="2023-09-13" version="1">MATNNTNNTQNTTHYTSNEAADLGQERYDQDTAAVGDRDDALYAAGPVLVRQGRAPAGMEQQVFAWSTFQYETSERDGREELKGDLHGGQLHRQNRAARGEPTGPPPPREPRGGRGGRGGRGGAMGGGQQGNVGLELVCGRKVDDNTPKLAKGRPEELDEDLFWDKPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWA4</accession>
    <name>A0A9P4PWA4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_346812</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWA4"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="27"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2451392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="544" mass="59635" checksum="EB98A544EBE1F4DC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWF6</accession>
    <name>A0A9P4PWF6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P171DRAFT_426624</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWF6"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19 22" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="21">
        <location>
            <begin position="36"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2450164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="611" mass="69300" checksum="E4BED83984637EA0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX67</accession>
    <name>A0A9P4PX67_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_503658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX67"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="485" mass="52569" checksum="3FB43695C6582E96" modified="2023-09-13" version="1">MADELAPPRKSTELEDSGTKDLGNDEHFSDASEGRLEKPDRSTATSPIPVTRVERVDDEPSYGEVPGTDAYNKRTQDAVPDEVEIVPEGQRSRSASRVSISDRPYTPGGTQIPKTVVEKIDPDAPSHGDVPGTLAHGLRAADAVPDIVLKAPEPPEKKPEEGTPTASISRSPVSSDSEDDDADDQDASAADVTEGDGAAEDDDGFGDDFDDFEEGGEGDDFGDFDDGFQQGEEDPETAFDKAPEQPSMPAPSLGPPILDFEELTTLEEIDIATQPYIDEIYPSLKEIPSITTNQAALRSIFVSERSESLWSQLVAPPPLQPPDWVRSRIRRLFLVSLGVPVDLDEILPASKQKKLVLPSIHIPGEKSPRPSADSRNGALGRVKKENASSTSVDSSASKSGKRKGPPPPPQLDISSTTMLCSTTDAALGNLTDEELRAHVKRLEELQERANEVFEYWQKRMESALGDKDAFEQVIESLVAHAKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX74</accession>
    <name>A0A9P4PX74_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ARF/SAR superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_346962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX74"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000832">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="183" mass="20744" checksum="6CDB8ED06A739B8B" modified="2023-09-13" version="1">MGASISKMMNKIFGSKEMRLLMLGLDAAGKTTILYKLKLDQDVTTIPTVGFNVETVTYKNTKFNVWDVGGQDKIRPLWRHYFSGTQGLIFVIDSNDRDRIEEARTELARIIQDREMRDALLLVFANKQDLQGAMRPKEVSDLLQLEKIAKDHVWKVEPSCATTGEGIFEGLAWLSNNVKLPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXJ6</accession>
    <name>A0A9P4PXJ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_451385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXJ6"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="194"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="274" mass="30406" checksum="535A4D46E850AC23" modified="2023-09-13" version="1">MDAADGRAFDLALHLAQRGEREAPSDVTAAPDLLILNQPISDFTVFAQLWTRSRYRLCADGGANRLYDMFCGELEARRDDFIPDSIHGDLDSLRDDVRSYYANRGVDVSQDPDQYSTDFGKAMQKIIANHLPASLATSREVLVLGTLAGRVDQGLGLLHEMLREETMDPRLRLWLYSETNVSFILRDSHNVIKGALSSRSFTENVGILPVYGPAMISTTGLEWDVQSWPTQMGHQVSTSNHVKADELHVATDTPVLFTIERATSSTDNHATPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYM3</accession>
    <name>A0A9P4PYM3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_478304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYM3"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="966" mass="108051" checksum="0C2A36C16ED9693E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZU1</accession>
    <name>A0A9P4PZU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_346553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZU1"/>
    <dbReference type="OrthoDB" id="5402633at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038038">
        <property type="term" value="C:G protein-coupled receptor homodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14939">
        <property type="entry name" value="7tmD_STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.920">
        <property type="entry name" value="Pheromone alpha factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027458">
        <property type="entry name" value="STE2_TM1-TM2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009:SF1">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02116">
        <property type="entry name" value="STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00250">
        <property type="entry name" value="GPCRSTE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="378" mass="42161" checksum="72BA9334B2EE47EC" modified="2023-09-13" version="1">MSDPLPPPEDVYSQELVLYAPDGSQFTTSMVEIDWLRHFGVRVAINWATQIGASVTLLLVLLLLTRREKRNSSIFIMNSLCLVLNTIRSVLQCVYLTTPYFHPYAVIANDYARVSPAHRALTVASNAITLVLVVSILISLSLQVWVVCITAKKLQKWIIMAVTSVSALVAIGYRFAVMVISNKQTMKDEGMEYYNGLVNDMYIAFAVAVWAYCAVFTYKLGHALLERKRLRMTQFGPMQIIFIMGCQTMIIPAIFTCLNFYDSVPELASQSITVICIFLPLSAIWAGLVANDSSVAGSGPDSHQRLFKNEFARSSSTTYGERSHLTRNTFGSGKEPESPRVHHYHQTKDSVDNGIYMQKEWHVEAGATGEPSELGHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4Q008</accession>
    <name>A0A9P4Q008_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_479033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4Q008"/>
    <dbReference type="OrthoDB" id="3210850at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40344" checksum="910CAADB6DC3F6D5" modified="2023-09-13" version="1">MAFLWSSYAQALPLNRGSSGSYVEPRKDSVYTDPTYGTSTEGRLAYGLVSFVCLFSLAFVLGIRAKRFEKKKLKFTWLLVHLQTLIALGLVISSSILVVTFGTTTQAQCFSAIMVCVAFYITGKICLYLFLLERAHVIRAPFIRKRTDDWVWVGGTCFVCVTFGAISIWGLITPHAELSPEDGQCRVGLSKIPGYLLLIFDASINAALTVLFVGLLRPVLKFREHTSTCHDHVNPPASVNRFRKAMRQLSSLGVEEHEGRDNFFISIKKVLWKNVIGSGVTFLASAANLIVFFAEKNNQLAFVCLVSCMADVTCGVLVVHWLTLGSNEEIHASPSVTRNHAPSLSSSSTIAVVSKPEDIVKPSKPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5N8</accession>
    <name>A0A9P4U5N8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_425554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001517">
        <property type="protein sequence ID" value="KAF2437288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5N8"/>
    <dbReference type="OrthoDB" id="3669279at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF6">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="118"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="284" mass="30046" checksum="583DE3F495FFCAFD" modified="2023-09-13" version="1">MAIPASLLNATNAFPLWDTEPMTDAFTLTHPDNHAVVTHVSRPWLFHFAPPHPSPTARGVLIIPGGGYTQLMIDREGTAIATWLTTLNLPAFLLLHRFPSSTTPPQAPLDDAHRALALIHTHNLAPHGLGLCGLSSGGHLAAALLAAYPPSWTPPNPADVSPKFDFAIIAYAPISTNAKGRTVVAGKPPLEPPQKQALYNALQPDVQLRDNPPPTFIVYAGTDEVVPVANAYRLAQALGGKGGMVELHVFGDAPHGFGVDSVGLPVAAWPGLCEGWMRQVGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5Z9</accession>
    <name>A0A9P4U5Z9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxisomal biogenesis factor 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_525425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5Z9"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2439579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="237" mass="26087" checksum="9B674C79CE82CDA5" modified="2023-09-13" version="1">MVADALIYHPTVAQYIKFIATTVGRDKALRTLQYLSRFLAWYLYRTNHAAASIAPFEATKKQFGLTRKLIRVGKFVEHFKAAAIASDAKSVDPVLRYTAVGRQLGYAGYMLADNAAVLDAANIYKYPASTRLVREGNKAWFTGITFSILSSLYQLYRLRERSAKLSSSKTAEAEPVVEAKKIAREANAVRLQLVSDLCDITIPATALGWAKLDDGIVGIAGTVSSLLGVYTQWKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6Q7</accession>
    <name>A0A9P4U6Q7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_499724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6Q7"/>
    <dbReference type="OrthoDB" id="3800563at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040447658" evidence="1">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="236" mass="23884" checksum="4CD6D614483AD10D" modified="2023-09-13" version="1">MRYIIASTLFSAAAAQATIATIPVSSPAILNLPAIPVLPLQGIPDVLSGNGYNSIADSLNKAAQSLGIHADAAAVANAKITGNVSANPNILATFDLIKAAGGASATLWQLAYDLESKVCSVATSINQQNLATQQANLVAAVQAQITAIARLRQTIMATVSAVQSQAGAFSDAEKAIITSAIQGLVSSVNASSQPLLILASGLKNVGITTISDLANTLQVQSNALATYAARVDFTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6X7</accession>
    <name>A0A9P4U6X7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_371973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6X7"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040339937" evidence="1">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="251" mass="26333" checksum="EE92F850C70E6A04" modified="2023-09-13" version="1">MAINLRSGLFIILALALRAAASTCAIMVTETVYVTATCAPGECASATAGSTNVGLISSVLASSTAPDNFHELTPTPNHGSIKNSCNYEVYVDSIGCGKGAKQQLIPAGQTWSEPLRSCPAEQGTVVYKVSKADAPSKPVQFEVGLSIEPGMENSVWYDISFLDCMRPNTTDLSGCPGWEGGVQCVPGKQGCQVFVCGAGEYCDGSTYTVPEFGIIVSGKYRNDDWRVKAGSPVTSCATRQEGIAFELCAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U750</accession>
    <name>A0A9P4U750_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U750"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="22"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="392" mass="43473" checksum="C32BB89049E0C6FA" modified="2023-09-13" version="1">MSKSFDVAAARERFPALKQDQVFLDNAGGSQTLDSVIDSITQYLSKTNVQLGASYHTGKISNTKYEEGYQAAAKYINAGRDEIVLGGSTTQLFMNLSSAMKIPEGSEIILSKMEHETNVKPWLVMADRLKLTVKWWESPKPELKLTPENLKPLLSPKVKFVACTHVSNILGGIHDVKAIADAVHEAGALFCVDGVSFAPHRKVDVKAFGVDFYAFSWYKVYGPHIAVLYASNTAQEHVKPLPHYFNPTKTLEDKLAFAASNYENVQSIPRVVDYLADKSDVIAAHEGKLQTILLDFLNSRDDITVLGSTSADSAVRVPTISFVVDGRNSKEVVEQADKISNFGIRWGHFYSKRLCDEVLGLAPEGVVRVSMVHYNTEDEIRELVEVFKKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7B9</accession>
    <name>A0A9P4U7B9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_435832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7B9"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2440015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="281" mass="31118" checksum="5FC5CE10629C25F5" modified="2023-09-13" version="1">MAKLSLTSTLRMPSGYEIPVLGYGVYQTPANVAAEVVGHALEVGYRHVDSAVAYRNEAPSAEGIKNSGIPREQIFFTTKIPPKDMNYENAKKHVDNSLEATGFDYVDLYLLHSPYGGKTNRIGAWKALVEGVEAGKIRSIGVSNYGVHHLDELEEYIKSTGEKEGKGKGGILSVNQVELHPWLARKDIVDWCNKRGVILEAYSPIVRATKAEDPLLLPLAKKHNKTTSQILLRWSLQMVSSFFQSTKAQTHTCVGLCTTAEIGNEVTHRGERTTLRLRAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U866</accession>
    <name>A0A9P4U866_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Co-chaperone Hsc20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_59184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2441979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U866"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Co-chaperone HscB C-terminal oligomerisation" evidence="4">
        <location>
            <begin position="157"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="240" mass="26376" checksum="A4A7B13D6DE04FB2" modified="2023-09-13" version="1">MRSFRPVASALRAPAPFTSSRQAASQSPCLRTAPSRRHQSTSNSPSTSTATPNARGSTPQSTPQTHFDFFPTAIPSGPPPTGHFTIDTTALKREFLQLQARAHPDLHPPESKSKAQALSARINEAYKTLQNPLLRAQYLLSLRGVEVAADETAKVDDPELLMEVLEARERIEEAGSEEELVGMKAENGARIAESVRVLEGAFAEDDVERAKGEAVRLRYWINIQESLDGWERGKPVVLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U928</accession>
    <name>A0A9P4U928_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_433338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U928"/>
    <dbReference type="OrthoDB" id="3890746at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="208" mass="22843" checksum="2FD013A405A4EB5E" modified="2023-09-13" version="1">MKINPAPLHLAQTVITGLVVAFSIAILGTAAHTLDVFNKQQTSNPWWLPLWPQHFDVHGTNALIASATVTLALSGVFLVMSLIPQVNLANKHTLRALLALGSAGPSSLLTVVTVIYVHILNARSELDTIQTWTCKYKNSAPMQQDMTLASNMGNSYFGSLCHQSKFALYGTLVVFMLLCVSMGLSVVGWMADKWSERQERKELEMQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9V9</accession>
    <name>A0A9P4U9V9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_393043</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9V9"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="68"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2441638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="252" mass="25950" checksum="9032CEE1F5D29AA9" modified="2023-09-13" version="1">MVELRKRKTPPPAPVRPAKKEKKAPKSKVEKVKEAIKEKVEAVKEFSGKANGEPSGESVVPATGAIVPKVGDTIPLTSFGGEVETHEGAKTTLAKLVEESKSGVVLFTYPKASTPGCTKQACLFRDSYEPLTVGGLSIYGLSTDSPKSNTTFKTKQSLPYPLICDPSQSLISAIGLKGPKSAKRGVFVVDKTGKVLAAEPGSPDGTVAVVKKIVDGSTSADGPPTGGAASAEDAEAAKTASEVADTAAKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAC4</accession>
    <name>A0A9P4UAC4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_31634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAC4"/>
    <dbReference type="OrthoDB" id="3747946at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="204" mass="22389" checksum="F32EE37FDCC6D688" modified="2023-09-13" version="1">MCLCTQYDSPTCGHSWTSMTESCGYGQDLLNCPYRQTVNYLVAPPYTCPTCNGGFADGETLQMIQGPWGCNQLVRNHYGGDFAVGNTWAGSLEMPLWSGSMRGGGGFYGGDTRFAGPYSGGALTCGPSFTASASPGITPNQRMICNEPYASACYDDCCYGGYDNGRRSRYGGGYEYADRKRQRRYDYQYKYRRSSRDGQGCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB32</accession>
    <name>A0A9P4UB32_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_431902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB32"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040531022" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="326" mass="38137" checksum="8B5A9B4F9F7BB86D" modified="2023-09-13" version="1">MRMRNVSAWRTAALLVLLAGTAHASLGDRLPEFKDCLKVCREANCGEDATPIPLHRRLLLWDCPAECDYSCQHIVTDKRLARDPPYMQPVYQFHGKWPFYRFLGMQEPFSVIFSLFNYLAHSWGMAQIREKIPPSFALRKYYIAFGYFGMASWTFSMIFHTRDYNLTEKLDYFAAGAQVLYGMYMAAIRIFRLDRREPIRQSVLRVWTTTCIILYTLHVAYLTFWKWDYTYNMAANVAVGVVQNLLWSGFSFTQYRKVGRTWAMWPGFIVAWILVAMSMELLDFPPWKGMLDAHSLWHLGTVVPTIWWYNFLIKDAQEGLAGSRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB46</accession>
    <name>A0A9P4UB46_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB46"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="473" mass="55730" checksum="5E1CF43E1A24C0D5" modified="2023-09-13" version="1">MVYNDTSSAAKHNDPVDWVPFVLLFIVVGTFFIWCCCVGAWLARLWYYDGQLHKKFPKYDIQPLYLRERLAREEEKNRRESQKVVDSRHLNRDVTTMSFERVQEFDSSSLRKRIFESKRISRLPAFEQDDGGDGSEFPDMPVDMPADEYNQQHFPQHYDNFEDLGLSELARDDWLTYHDDEQITARDQILEDFRENCIQMRPGREAENACGELWQEVAKFLAMRYPARFWEQKENGVRMLYDDNSKESYSLDGPFGWLTLDTMARLVREDFCIFIKSPFSAQYTLLAGATCFPSGWRLRARVGYSVESQQEAVLPWEKLPEILSYIDEHRNSSRYKRHVAFIQTSLPHEIDLTKKYFIQESKDFFSGNISFLQPETLHARIERQMFTRLPISGAIVLTTRLQIEPLVRMQDHKLRHLAKDIRSWPAHVARVKGRDLWGRAVLGFIEQFPMARDDESVVLTEDDEDDDVKKWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC47</accession>
    <name>A0A9P4UC47_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_522261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC47"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="164"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="486"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2443767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1061" mass="120283" checksum="EEB5E131E81AAF8C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD50</accession>
    <name>A0A9P4UD50_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD50"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040429565" evidence="1">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="170" mass="19009" checksum="78B16F8A4008B6B8" modified="2023-09-13" version="1">MQYDKMQNSKRHLCTKMAFLFLGLRLNFVSLGTGEKAVIGRCELNHLVLNSRASISQPNTTNTTLPDNIFEEPVDTTSVPGDYGPPTSRNLQAPRSPAETFVGTRCAVYTLSADALPYRLPMKPDRQKRTPSCALRLPFLAFGDHIFERALDPVFSISSLEMLSRMCRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEI7</accession>
    <name>A0A9P4UEI7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_430079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEI7"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="196" mass="20997" checksum="553614E910A1FA90" modified="2023-09-13" version="1">MVAHEGHDMASMGGMDMDGTSSGSSMSMGMPMSFFTSTTTPLYSEAWTPASAGAYAGTCIFLIILAILLRALLTAKTFLEYRALQSAMKRRYVVTADQQTATDKAFNDANSMTGILTTNGLQENVRIVEAPARHVQPFRFSVDLPRAAIMTVAAGVGYLLMLAVMTYNVGYFLSVLAGAFIGELALGRFNQGAMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFN8</accession>
    <name>A0A9P4UFN8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_429084</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFN8"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="130"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="221" mass="24401" checksum="A188B074B4A6DB93" modified="2023-09-13" version="1">MFSVFFTYPLEVIRVRLAFETTAQKRSTLRGICTKIYHEQGAPTTHHPTNPLSAAAATVVEKGVPQTGLANFFRGFTPTLLGMIPYAGASFLAHDTMSDLLRHPALAPYTTLPHTSRTESETTSYKPAQLQGWAELSTGGFAGFFSQTVSYPLEVIRRRMQVGGVVGDGHRLGIAEVAKRIFFEKGWRGFFVGLTIGYVKVVPMSATSFLVWERGKYYLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG07</accession>
    <name>A0A9P4UG07_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_216915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG07"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="334" mass="37676" checksum="379522327A8A3E4D" modified="2023-09-13" version="1">MNTTKRQKQRKVLLMGKSGAGKSSMRSIVFSNYVAKDVRRLGATIDVEHSNIKFMGNLMLNLWDCGGQDGFVENYLTHQRAHVFSSVAVLIFVFDIESREFAADVISYSSIIRALAEHSPSAAVFVLIHKMDLVQARLRQQLFDERTEYIRAASESFAPTVEFFATSIWDQSLYKAWTQIIYFLIPNARSIEGLLRELAEVVEARELILYERTTCLMVTHVTRDVEAENPFSDRFERISSILKTHKQSMAKHTGIPAGSANFAEMQIKTGRFMFFITRLTENTNLAAAIPPSEQVFNAARINIALARPRFAELDIASKPRPAVQQAFAHSADSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG48</accession>
    <name>A0A9P4UG48_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_453049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG48"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="1">
        <location>
            <begin position="13"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="812" mass="92460" checksum="04642F16E5B2EF6C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH16</accession>
    <name>A0A9P4UH16_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extragenic suppressor of kinetochore protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_351073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH16"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="890"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="906"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="960" mass="106070" checksum="AE35727218251CA6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIN9</accession>
    <name>A0A9P4UIN9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_479586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIN9"/>
    <dbReference type="OrthoDB" id="3921377at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="161" mass="18190" checksum="1D9D7CBB23B9049F" modified="2023-09-13" version="1">MSAKSFGTLIDSEPSTPAYSPRQGSNWDGSTLVLLPPVKAGEATPGEPAWDMLVPLQKPPKKRFSRHKSKTLISKEMSANTTLSSLPVVSIQEEPQKENHTPTEEDGEKKEEEQPAQSDPLGKLTLRVKNLLKRRNPAEKKERKRSYYELERVETVHWTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ18</accession>
    <name>A0A9P4UJ18_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_479938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ18"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="351" mass="38565" checksum="D459B885540E4D57" modified="2023-09-13" version="1">MEHPTQSVDYEAPFNPRLDGYQIPGGSSSGSASAIASYEWLDFAIATDATGSVRIPALWNGCFGLRPSTGALSTEGVVSVYPGFDTPGLLGRIKNKPITSPRIVIPPDFFTNITGDQLQLIEQFVRDLEDSLGTTAHRKTIADTWKSSAPVDERNIDIYLGNATSYSYYHAAFHAFDDFREAYKIKYDCAPFVTESNRWIWQLGSEVSSEQRNDMKSRIETFRTWFLKHYMKPDEQGTIIVLPISDVKPNYRDAYPAQTNGRATPGLRTTYLSPYVGAPELALPIGHVSFESRISGNTESLPVAVGVMGLPGSDMALVKLVLESLRASKRPTVVSAGTARMWACEDETGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P3V7</accession>
    <name>A0A9P4P3V7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P171DRAFT_373018</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P3V7"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="353"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2437830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="480" mass="54373" checksum="418DE0BFAA35A510" modified="2023-09-13" version="1">MPSHQPVAGMMAIDPQYVSQPSAMASTSEPNRNPKYDPKKPHITDLPITKGNWYKHVNWLNVFFIVGIPLMGCVYACWTPLRWQTAIWAVIYYFWTGLGITAGYHRLWAHKSYNASLPLKIFLAGVGGGAVEGSIRWWSRDHRAHHRYTDTNKDPYSVRKGLLYSHFGWMLMKQNPKRIGRTDITDLNEDPVVVWQHKNYLKVVIFMGLIFPTIVAGFGWGDWIGGFIYAGILRIFFVQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDYRNAIEWHQYDPTKWSIWLWSKLGLATDLKQFRSNEIEKGRVQQLQKKLDQKRAKLDWGVPLEQLPVIEWEDYVEQAKNGRGLIAVAGIVHDVTDFIAEHPGGKALIGSGVGKDATAMFNGGVYLHSNGAHNLLSTMRVGVIRGGCEVEIWKRAQKENKDVQIVKDEAGNPIIRAGNQVTKVHQPIVSASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P681</accession>
    <name>A0A9P4P681_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_437200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P681"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="59" mass="6638" checksum="1B40BF1421F19E7D" modified="2023-09-13" version="1">MLFFYPTDLSKLLNCIFVYLPINYPRYAASIFAANGFLRSAMACGAIHFSQPLFKNLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6A1</accession>
    <name>A0A9P4P6A1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_491313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6A1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF7">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="562" mass="62081" checksum="A5716924CFED3AA7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6J6</accession>
    <name>A0A9P4P6J6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_527023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6J6"/>
    <dbReference type="OrthoDB" id="3672266at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="654" mass="73991" checksum="DF2AF5A6F4F9A51C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6T6</accession>
    <name>A0A9P4P6T6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BSD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_436113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6T6"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="236"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="405" mass="44282" checksum="6D6421E7F76F3893" modified="2023-09-13" version="1">MDAAYDHIQEEAYPQDPPPPKDTAAPASNNFQSEVQDAYKAISSSPWAARLGGFLGTVKKQGEQYYDGASKQATAGISTLIKHTRNISVNSGDASSSTATETTPSTSKAPAHDPDAHPDRPESLPADIVKEAEGMLSRFRAEAAKRLKDIEKAEDAADEALLKFGTNIRSFLRDAVTIAPPTEDAAGNPGAVLFESKDSSGKKVVHATRFDAQLHVIHSSLDSFLKDPVSPEWAGWRKDFDVEKKTDEIARDLEKHTELRTAMETLVPEKVEYAAFWERYYFLRHVIESEEQRRREMLKASAPTDEEEVAWDEDSDAESDADKTSTSTPQAAKSATNLAASQGTLKPPAEDTLKPAQPRRSNDEKSVADSDASYDLVSGATSRAPGSPQEKKKAVAEESDEEDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8D2</accession>
    <name>A0A9P4P8D2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_435125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8D2"/>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37892" checksum="384629FB1B95D5A7" modified="2023-09-13" version="1">MGRFFLPRKWRMPKLVFGLIIFEFPFTVANLALFGIAAPNTYRTILWRVGGEMGFNSDPSQVAYAAYNYQKMETPVVWSSLNTNYNMYVGVVCMFFYLIKFTLWLLHIFYPILSLILHIALAALWAASLYLQTAPDTVDPAHQNKGAPWYITKSCGIVSDKTERGYCMQAKSAFAVSVIMLATYALLIVLSIWSLIPTPEARAAHDTKLAEKKAEKELYASEPYDAEMTAEEQWQHMWELQQLPRTPGTTAPAPAPWAKVPATPRTTAFNQLHGGHQDIFAHPRSPIHASPQQYQHQQQTYYPPPGQDGVGYAGVAPQGQQVYHDYVYDGNGKGTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8L1</accession>
    <name>A0A9P4P8L1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_477354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8L1"/>
    <dbReference type="OrthoDB" id="3800411at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040453123" evidence="2">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="148" mass="14976" checksum="72B0F83C9E04711D" modified="2023-09-13" version="1">MRYAAGLLLFGCAAAQLQYGQYSDPPGESPTGSFITVTYMSSVYTIPIFDPSNAPTYGASKTTIYRPSETTESAKHSHSASSHNPASSAVASTREKSSTLETSLSPSSSAPSSVPPAPAEQTGGAASRIHSCGAGAVVGSVLAGIALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8N8</accession>
    <name>A0A9P4P8N8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_457340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8N8"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="469"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="584" mass="63562" checksum="79966C79EB35FE4C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8V1</accession>
    <name>A0A9P4P8V1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYND-type zinc finger protein MUB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_458183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8V1"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="598" mass="66399" checksum="6E6A62A483C1EC59" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P980</accession>
    <name>A0A9P4P980_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_436762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P980"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="88"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2438869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="409" mass="44587" checksum="392012D56BA35983" modified="2023-09-13" version="1">MARKRSSQHAAPQPTPPTASGSAGNPISLRGSNSPAPAAPAIPAPPTGRSGLRSAKSLGTVAVGQPTTQGNRVAKAAPKKKEPKPKPIKKECFICATTRQVSNCAGRGFKAVEGACDHFQNTCNVCIGKMIKEKIVKRDLDEAVLVCAFPDCEHVLDYNTIRQMIFKGARENWDTALLNHHLSNSENYVPCLNPNCGRYFSVEDCQAKSSESRSKNKADRSHPITCPYCEEDMCLDCMRPWHRSTSCDKAKIAEEEQSLQVIKNISKPCPKCGANIQKNGGCNHMKCRHCKHDFCFSCLVGFGPNMQHAEGCPERNQNILQDPRNWLPDDVNIGNWMPAMMRAAGLPDLPQQPGQVLPPPIPPPPNPVGAPRQPEPRGLLGLLQMIRAFHHNHPEVNGNANGGQDQPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9E2</accession>
    <name>A0A9P4P9E2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_436572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9E2"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000288">
        <property type="entry name" value="Spermine/spermidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="7">
        <location>
            <begin position="334"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="579" mass="63065" checksum="EB8E4EA5C7096A00" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA17</accession>
    <name>A0A9P4PA17_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_436545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA17"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="52"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="397" mass="44309" checksum="362465845555BDB7" modified="2023-09-13" version="1">MPQPAPARSPARNPLPPLPLPPGVTEHYLHCPSNGLTFHLLEAGHAPDNQRPLVLLVHGYPELAFSWRKVMAALADAGYYVVAFDQRGYGRTTGWDGSCSPFAKTNQTEFTITNLVRDVVILVHALGYRAVKCIVGHDFGAVTASMCAWMRPDLFHSVVLMSHPFKAHPGLPFDLLHGEPANPPPPIDIQKDLAMLPEPRKHYKWYNATSTAALHWYAPNQGLAAFLRGYWHVKSADWAGNNPHPLAAWSAAELAKMPLYYIMPFAKSMPETIELMMRGEDPDKTKRWLSDEALDVYVQEWRRTGFQGGLNWYRTMTDPGMKKDIDLFAGRKIECPCVFISGAKDWGNYQEPGALEGFPETCVQFRGVRIIEGAGHWPQQEQPETVVGEILGFLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA32</accession>
    <name>A0A9P4PA32_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_525124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA32"/>
    <dbReference type="OrthoDB" id="3783056at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="166"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="890" mass="98813" checksum="F14303FD863347DE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBT7</accession>
    <name>A0A9P4PBT7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_368073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBT7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF213">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040355471" evidence="3">
        <location>
            <begin position="18"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2440219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="639" mass="69580" checksum="28AC55DA302B6EB8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC12</accession>
    <name>A0A9P4PC12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_316803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC12"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="495" mass="52432" checksum="1896B0286BE71D03" modified="2023-09-13" version="1" fragment="single">VIFALCLAVFLTALDRTIIGVTIPAISNDFKSFDDIAWYESAYLLTFAALQLPFGKVYTFFPAKWAFIVLVAIFEIGSIICAAAPNSTAFIIGRAIAGIGSAGNMTGANVIIANLLPLEKRPKYMGFIGATFGLASIAGPLLGGVFASKVSWRWCFWINGPIGLVALVVLVLLVPNNPPAQDHSDKPLVDRLKAYDPVGTALLTPGLILLLLALQWGGNGSSWGSARVLSTLVIGIVLILAFIASQAWVGDNGTLPPRIIRKRSIAAGTTVSLGFGSTLIIVTFYLPIWYQAIKGVSAVDAGVRMLPYFLITVFFVIGSGAAVSKQGYYTPWLIAGTALLTIGCGLFTTFRVDTSTAKSIGYQLIAGAGMGMSLAQCNNAAQTVLSHEDIPIGITIINFGNFVGGTIFVSICQAILSSTLQSRLAQKIPGLDVSSIVHAGATDLAKLIPVDQLPVFHAAYNEGIVNVWYCALGVSAFAFVASWFVEWKSVKGPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC20</accession>
    <name>A0A9P4PC20_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_457112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC20"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2441301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="430" mass="47360" checksum="1DC5F90851A2B212" modified="2023-09-13" version="1">MAKENSPLNIIILGGGIAGLTTALALTKYAPASRPSPRITLYEVRPEPATIGGAVNLTPNALRLLSHLGALQEIRANNYGKECGAVEVFDLYSGSKLSESSFRGPEGKGLGNPPFTALRITRGESLQGVLAAIEKHSNIKLICGKKTTDIKEDANGVNLTFEDGEIVSADILIGCDGIHSVTRLKHVEPERKSIYSGICNAFGFALRRKTASGAYEETHFETSGMNFGRRGILLTSFHDEKKDSIYVGALMQVPEIASRDGWKARGADAEKTRQDILERYAGAANPLINHLIEDAQDLYLWPVFTLSKGGKWATDRVMLIGDSAHAMPPQGESTGIVFEDGVLFARCLGRWMEKNDGAPVKEAFDAYERLRRQRIDTAFDESQSVVKTVNDAGWLGHRIKLTIVPWYLWWTRSYREAHFIEDVTTSDLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC73</accession>
    <name>A0A9P4PC73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_434979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC73"/>
    <dbReference type="OrthoDB" id="5421971at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="495" mass="54858" checksum="62C2D018E8231ACC" modified="2023-09-13" version="1">MYRRGDPRWNRTLQNITDTVEHANESAQEGLYSFAHAYVTPCLSSLTQCANACTAPCFPSHNDRRRHRAEQSFDFYDDWDEDEDDGLLGWGHDNLDRLWGATANYGTTSQPSRPRAMSYGNSNRNRNRNRDPRFTRPRRKSAAPPHDGGPDPTIIPSSSYFGFLGRLPFRLGGKVLRYRPSAADLTEHPGQARRSYDEASGGDEVQPLIEDSDEDAEAQHGSDFKTHGRKRSQTNASGHTTDSLSSRGDIFPSEDELDDAVPLDDEFAVALERRTTGQWHDDVSSGKGRASSGSKNKRPSASRVSTRSASSCNTQDPGRFSHEVSVTRLPSEPTDEPPTLTDLEQEEEQLRLQEEAEVQRRRQEAQQLAVRRGLVADHQHLAVPRRPSPSTNSTALSGHDQTGTPSTTSSPFFILTVGSESYPESETALSPFPGVDTQTMPDSSSFHVDESDCSSLATTSNRPLSLKDKARDKQVDDNDSNFVPARLPHFDAQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC96</accession>
    <name>A0A9P4PC96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC96"/>
    <dbReference type="OrthoDB" id="3770652at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="158" mass="17865" checksum="85E7D07C567321C2" modified="2023-09-13" version="1">MSDAASSNMPMTTEDFYTEDQKKLVNNPLYNLLRQQVIADMEAYADEYDVYHDGGPVPVEVYKRGHIRNVIGFINFCISDALYNNPYKVVPVVYLASAGLLVLCIILKEYVIFQATKRLLKDPNHDDLFEKSLDTIASIMPVVVTLVLFLFPPLIANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD86</accession>
    <name>A0A9P4PD86_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_496698</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2441976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD86"/>
    <dbReference type="OrthoDB" id="5271017at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040158430" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2441976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="232" mass="24789" checksum="3A5A137B2A0EF0FA" modified="2023-09-13" version="1">MRFFLFGLMLAATARAHYRFSKIVINGTPEAQEWTAVRQTKNYQGNQGVTSVSSADMRCYQNKAGSATATIAAGETLGFVANAMVSHFGPLQFYMAKVPDSANINTWEASGNVWFKVASIGAMQGNGPLTSDEKTWPAYKKTVVDFQIPKNVPSGKYLVRVESIALHQAQSVGGAQIYLSCAQVEVTNGGTGTPGPLVAFPGAYSANDPGLLWSYYPVATSYKAPGPAVWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE49</accession>
    <name>A0A9P4PE49_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_433849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE49"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="135" mass="15851" checksum="457B6FAAAE69A24D" modified="2023-09-13" version="1">MSKRFHLSKVCRATYKETRLLSLAGAMIFCWLIEDESKRALEDILPVQREAFSTLVIDYSDLCYYSDDHVGFVQAYQKDLSGLKRVFLDVFWTKINPADERADDTVQVEKAVKLIRQALGEDIHVEWGWWRKEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFA6</accession>
    <name>A0A9P4PFA6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_55526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFA6"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="132" mass="14827" checksum="1BDB8D7CCBE52C04" modified="2023-09-13" version="1">MSISVHNYAGTEEKSEAFHYSQAIKIGNVVKTSGQGGWDDSGKVVSDLKKQVELAFLNVEKALQAADKSLSWKNVYAVRSFHIDLDESADYVIDNFRKFTPDRRPIFTCVEIRKLGIEGMQVEIEVEALIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFU1</accession>
    <name>A0A9P4PFU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_64015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFU1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="161" mass="17452" checksum="83CC50358B66F506" modified="2023-09-13" version="1">MYISRSRARVDRHVGQQAVAFADAMLVPAVHSQSGHPCGWRGDSGSKTATTERPHLLARGWPACGATLHMRTWAVFGVLTLLDVGASGGWMSGRPGEGAWDGCLLSARRGYLRISRASNLVTGPMAMPHGVAPHSRRQTRWRRRSHNARGTETGDGRSGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG74</accession>
    <name>A0A9P4PG74_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable aspartic-type endopeptidase OPSB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Probable aspartic-type endopeptidase opsB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_39901</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG74"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="49"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2443551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="464" mass="48887" checksum="067907BF5899464C" modified="2023-09-13" version="1">MRTTVADLSQSPKVVKLDISRRHVNPIHHDRLRRRDTVQVTLDNLETLYFMNASLGTPQQNFRLHVDTGSSDLWVNAANSRLCSSISEPCSSAGTYSANDSSTYKYVNSIFNISYVDGSGASGDYATDTFHMSNPDLTVKNLQFGIGYTSSSYEGILGIGYQVNEVQVNRAGLRPYPNLPQKLVDDKTINTNAYSLYLNDLDASTGSILFGGVDTGKFNGTLSKLPIIAEANTYAEFIIALTAMGDDGDKGSIFENENVAVLLDSGSSLMYLPDNVAQALYTKYNARYDSTQGAAICDCDLANQDGSLEFTFSSDGPTISVPLNELVLVMGYQRGQPICILGIGPSGNSISVLGDTFLRSAYVVYDLDNNQIGLAQTVFNSTQSNIQEIQSGATGIPGATGVPNAVSSLDVQGGGGRIGGPSVTGSNGGGSSSGFGSPAATPMPWHAAGAALAGAGLLMGFNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG82</accession>
    <name>A0A9P4PG82_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_521927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG82"/>
    <dbReference type="OrthoDB" id="449091at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="130" mass="14176" checksum="D5B29AB904041CEC" modified="2023-09-13" version="1">MASGPLIQLPLPTMLGFVEAANWDTITATHLALQVSRNLHQHFQDDAKIVSFTSWNVTTNGTSNVMTLALGDTALPNFHSDFPVQPSNSGISVRDRKGTHSYGRNEESVGAEFCERSGWNSCSGETTKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG84</accession>
    <name>A0A9P4PG84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_40493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG84"/>
    <dbReference type="OrthoDB" id="3789699at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="311" mass="34752" checksum="DCE5DA7C896D58B4" modified="2023-09-13" version="1">MPRFELRIPHATRYRHQCICSASRLSNVYGAVSTAYTLIAVRSLSDRSTNTLPTNAYFQLPITFTTRRLPTSKIALLKGEKHHMTYNLPIQTAALAKERKLRLREQFCDVFNTSAPTFYFSVEATPPRLSVPGANIKFSVTMEVLLSLPGKLYNFQILDITITSMKFLVRSYTGIRTLLPTSAQTPSAVNASEVTCRRETFTRIEFRQTQTPNNATFTPQQGRFEDQVCVATITLPKEVLPSFKAYSAWRGYRLECAIRLRVAGKEAEAKFANDLDVVASGEASFERAMAPADDGMSRQVAEAIVRACVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGK1</accession>
    <name>A0A9P4PGK1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_513758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGK1"/>
    <dbReference type="OrthoDB" id="10582390at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="397" mass="44814" checksum="2E8DB45A4EE9520E" modified="2023-09-13" version="1">MLPSANDTGSDNEGLSLTIETNPMPAIDMAKAESDELAPLTPIPALNDDKKASAATDGERTPTCNGGNDLNAYIASLIVENAKLAKEKADALQEAAKIQKEHAATTEKWKDAHARWTQANKLRSNLDQAYHRRVVEKDEAIAIIQPLRNKNAELLQIHADLGQESAELKGENARLVSEIQPRDSIIMKLRTEFVFLKETLDAERKQHEAVKAERDSLRKQIGAHNQTQRRDSDRERDRSRFRSRSPRRSPGSHHSQATRHDDYRNSRYKERSRGRTDYDGRDYQGYGRYVSNYDGPPSSPHRREPSRPAPRESDRLPTPCKTPDTPFVPDSKSPHEFLDMGKTKVGSNQLNPGEIPTAPRSQVLFSMRQAKKKLPSESRKRASLSKGVNQIDRYRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGM7</accession>
    <name>A0A9P4PGM7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS quinate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_391017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGM7"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF43">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2442993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="520" mass="57431" checksum="93E5D2EA426E8837" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGP9</accession>
    <name>A0A9P4PGP9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endothelin-converting enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_417868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGP9"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040123243" evidence="9">
        <location>
            <begin position="28"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="97"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="552"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2442586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="756" mass="83303" checksum="F36C937379758739" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH08</accession>
    <name>A0A9P4PH08_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_495678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH08"/>
    <dbReference type="OrthoDB" id="3756983at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="30"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2443807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="458" mass="48504" checksum="AA20A1C17AEEC3F7" modified="2023-09-13" version="1">MIGPYQRPCVGVHPTDAESPHARKSGTLITILGSALANLSDGFQQNLASPTNIVFKHLLGSAYTASAQTRISNALLVGSVIGILGFGYAADRFDRKSSMLVTSGLVVAGSLLSTVALAVRGSDRMLWYVTVARGAAGVGVGGEYPTSAAAALEGSNELFDAHRGPVQVLVSTLMATGGSALCTFVYAMALVGSSANVRVAYWAIHGMSAVLPVLVVLARWKMQDGRLFEESNFRKRKIPWVLLGRTYWRRMLGTSSAFFLYDFVNFPNSIMSSVIINGLVPGNNIRHVALWQLYLALMPIPGVLLGAWLVNKLGRRWTGILGLLCGYVVCGFVIGGLYDKLTTHSLPAFVVLYGLLQAFGHMGPGATIGLISCEAFPTAARGMGYGVAAGFGKAGAAVGTQVFTPIRAAAGPASTFWVAGAVGIVTSGIYYFLPEGNKIELEKADEEFERLLRGEKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHM4</accession>
    <name>A0A9P4PHM4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_432170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHM4"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="100"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="563" mass="61725" checksum="1EAA1D09AB42D1DE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIK1</accession>
    <name>A0A9P4PIK1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_521374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIK1"/>
    <dbReference type="OrthoDB" id="3774232at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="174" mass="20120" checksum="5C193FA44D275012" modified="2023-09-13" version="1">MAPARRDGHTNSDLDPTSRVYTLVVHDGEHRLHVHESILCQSSEFLKAAVKSEWKTLRENQNEIDLTDDHIDLFKVYVHWLHNKDQRLVLLRKHVSGVTYEEEIDQFFAAELYAFGEKILDRAFSDAVFKFGFTSKIGTYTPYQQKLCGEVAAILCEAAPEVSFVQTFVIYYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIL6</accession>
    <name>A0A9P4PIL6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_432992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIL6"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000144">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="171"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2443823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="292" mass="31878" checksum="CB50E27FD2D0BD76" modified="2023-09-13" version="1">MADTAGYPTDNSKTGLGAHDALHTGKRKRDTRDQGNSRPAPSANHGNSDLTDQAFASLAAHNASANGDDMQQQFDGANNQSMGETAAAAIAHYQMTVPQATELSFQPQSSTGDSSFNMGDHHQSQGMQDFSLEALKAATSSSRTGQSSGNGSPPTTSSHKPTVGSEEWHKVRRDNHKEVERRRRETINEGINELAKIVPGCEKNKGSILQRAVQFITQLKENEQQNIEKWTLEKLLTEQAITELSTSCDKFKGECQRAWDECAIYKRACENAGIVPDEIKDRENNAEQNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIZ7</accession>
    <name>A0A9P4PIZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-like protein rab-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_486508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIZ7"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001537">
        <property type="entry name" value="Secretion related GTPase SrgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="253" mass="27014" checksum="C1C0DA999CE351EB" modified="2023-09-13" version="1">MDDAASAGGAPRQTKEPLTIRLCEGRFSPHHDVTIGVEFGSRIVPVGPPASHALSINSPAKPAPSTTPAKSQKTPEQKHMKLSLWDTAGQETYKSITRSYFRGASGALLVFDISRKNTFLSATSWLSDLRQIAEENIVVVLVGNKSDLAPASTVAGEESADNKRQVSKEEAEEWCKENGVMQYVETSAKSGEGVERAFLEVAERIYQNIEAGRYDLNDRRSGVKGPGGGGGNSAKINLGMNDGRGKSAGGMCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJC1</accession>
    <name>A0A9P4PJC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_357731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJC1"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="207" mass="23701" checksum="16A77A755BE80192" modified="2023-09-13" version="1">MPQLDSKVAAIIDGAKGDESDEDALIAELENDSDLDAFREQRRQQLHAEFERAQQLRNRAHGTYAEVKDEKQLMDITTSTKLCVVHFFKSDFHRCSIMDTHLETLAPAHYEARILRINVDHCPFLVTKLKVQVLPCVITFIEGIGSDRIIGFEGLGRTPDTFTTRDLEARLIRAGVFERSKVTKEDERQAPRRTRAAQEDDDDDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJP1</accession>
    <name>A0A9P4PJP1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_385131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJP1"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="49"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="400"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="772" mass="87640" checksum="6FACD78A4C5AF2CD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJT6</accession>
    <name>A0A9P4PJT6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tubulin-tyrosine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_514632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJT6"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="460" mass="51360" checksum="F7827D04AAE37784" modified="2023-09-13" version="1">MAPKTDDNKIYALINYEDPYVQPLIVAAVKKHFPPDSIEFISALDALPSPSSRLLQWVQYESIDFPYLLSHASTSLANAYVIRKALIRKHYLSTTVANWVVKHPESVLARGVKPSVEFEVDYAEFLDDALVEAWELHESWERGRRDGGREWWILKPGMSERGQGIRLFSSEEELTSIFEGWDPESDDEEEEEEDARSDAGSSFSPTTGKKGGEEEKEGNGIITSQLRHFIAQPYIHPPLLFSNRKFHIRTYVLATAALSVYVYRPMLALFAARPYAAPSSTAFAGEAGDAEDALRAHLTNTCLQETGEREGSVGLFWELPDAIPDQPTFEEGEDGVEVKGLGGKWKDDVFKQLCSITGEVFEAAARGMSIHFQPLPNAFEIFGLDFMVGVEEDGALRTWLLEVNAFPDFRQTGDECKGVVEGLMESVVRVGVVPFFAPDAERDEGDAELVKVLDIDLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJX7</accession>
    <name>A0A9P4PJX7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_462866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJX7"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF107">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2445317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="532" mass="60355" checksum="05F09C314A828BF4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKG2</accession>
    <name>A0A9P4PKG2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_412697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKG2"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="35"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="224"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34058" checksum="4D50E67040B894D8" modified="2023-09-13" version="1">MITAASRRAIGSAAKRQCRSFSSTPAVGAPAEVKKLGVIGAGQMGLGIALVAAQRANVPVRLIDSSQASLDKGLKFADKLLEKDVGKGRISKEDAAATRERLTSSTKLEDLSDVDFVIEAVPEIVDLKNKIFAQLAQICPSHAILATNTSSISITKIAAATTNDPTDLSVSSRVISTHFMNPVPIQKGVEIITGLQTSEATLETALELCKRMGKIPSTSADSPGFLANRILMPYINEAIICLETGVGKKEDIDSIMKNGTNVPMGPLQLADFIGIDTCLAIMQVLYNDTGDSKYRPAVLLKKMVDAGWLGKKSGKGFYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMN4</accession>
    <name>A0A9P4PMN4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_276981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMN4"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15169" checksum="26C0FBD1B835E043" modified="2023-09-13" version="1">MKFLKIITRGRYAGKKCVIISPLDNGTKSHPFPHALVAGIERYPSKVTRRMSKKKQDKKSKVKPFVKQVNYTHIMPTRYTLELENLKGVVSADTFKEVSQREEAKKTVKKAFEERYTSGKNRWFFTPLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNC5</accession>
    <name>A0A9P4PNC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_223816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNC5"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2447376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="486" mass="53114" checksum="35091BAB247CA53C" modified="2023-09-13" version="1">MGHPKLNGSDVASAETPLSEDATLSGAEAARLLRKIDCRVLPMLFIVYVAAFLDRTNVSNALTMGMPKELHLMGEQPNTALAVFFVPYILFEVPSNILMKKLSPHVWLAVCTLGFGIVMITQGFVKNLGGMIATRFFLGFFEAGIFPGSFYLISFWYKREQAQKRFTVYFCSVIMASAFGGLLATGIANMNGVSGKSNWRWVFIIEGIVTCLVAVAAYFFISDFPSDAKWLTESERRFVLAQTGDRSAANDRITGKDLVQFFREPSNYLGALMYFAVVVPVYAFSYFTPTSKSTHLRTRPAIAQANGAAPPVVKTLGYTLVKTQLHSVPPFASAFGLCIVMAWLSDRVNLRLPFVLFSSALLIMGLSILMTVHVGFSVRYLGICLVCMGALGAAPSIVCWYLMNLQGHKARSIGSAFMISFGNAGGLVAPFAFLPKFAPYYRTGYAICMGVTVLGLVATALYTLLVLRKNRALTSAGAEKHTRFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNG9</accession>
    <name>A0A9P4PNG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_430204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNG9"/>
    <dbReference type="OrthoDB" id="10616298at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040412022" evidence="7">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2447300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="15190" checksum="A8E2C05C8F9D855A" modified="2023-09-13" version="1">MRLSFLRSFLLLAALAPQPHAMSLFSTSAKNATRAAVSAKDWVIKNPKIVVGVAAAPVVGVVAAPLALGAAGFTAGGVAAGSLAAGIQAGIGNVAAGSIFAGLTSAGTGGAALAVVQGVAGGAAAAVAGGTAYVVKTVKRKDEDIRDMEGAGKGPGPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP80</accession>
    <name>A0A9P4PP80_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_428783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP80"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040300044" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="393" mass="42723" checksum="586A939F6A3A89FA" modified="2023-09-13" version="1">MHVPNALASLLPLSLLAAAVKLPAPSGPYNVGFTQHIFNHTTPNDPTPGPGNIYLTSIYYPTRATPGPNTSVPYFDPTSARIWGEVFNILPADLESLETTLQWQAPLLTAEEDVDKVKTWPTLVFSPGGGMNAGYSTSLLSELASQGYTVLALDHPGEAPYLSLPYGNPGVVGWDIYMPYSDELIVEIYEFRRADMLALLCPNGYPALVELNGAYFNTEAYGAFGHSTGAAAATGAMDRRDSIVAGFNIDGGLFGDSVNASLHGRPYFMTMNPNHFAQDADTWPAFAERYYNESKIAPGWLDWTTVEGSAHLAFSDIPLWVELLPQIPNSTAQVNLGNVTGSRMDALLKTYTGAFWEFVRGGQYNATLLDGEVEEWPEVVFDAKVRSNGTQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPZ3</accession>
    <name>A0A9P4PPZ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_236420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPZ3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="100" mass="10950" checksum="76004086EF4BC969" modified="2023-09-13" version="1">MKRICRPRVAQTTRPISPCRGARRRAFPHVPCRPCASSSSDVASRHCTASTQSCPTPNPSTTRPHMPPSVPADLLASPPRTRSALCARQVRTEHRTCSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQI3</accession>
    <name>A0A9P4PQI3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQI3"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040516354" evidence="1">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="193" mass="19810" checksum="7599CC52F280BB62" modified="2023-09-13" version="1">MRFSLFTAATAALAGSAAAVDHLVVVGNGSLTFEPANLTAAEGDTVTFKFWPKSHSVAQAAFASPCTPLQNGFWSGFIPSEKGPATETFMINITNASQPLWYYCSRGNHCQDGMVGVINAPATGQRTLKAFTEAAANATNNTSPATTAGAGGMLMNGTSMNGTSDNTGAASFMSASNSALFTVVVAMVASFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQT9</accession>
    <name>A0A9P4PQT9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_404990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFP11/STIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQT9"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="585"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2449604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="707" mass="78926" checksum="F3DC8C420AABD567" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRN2</accession>
    <name>A0A9P4PRN2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRN2"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="115"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="293" mass="33716" checksum="4A5A5EAD46ACACC3" modified="2023-09-13" version="1">MNPYEANPENIPPTDRYADVPLYGRYLPRPTDFTPDAKHINCTAPEYLEYWSTVLKKCTESNRIYENQDGGRDVFALGSVIIKSSHLKGTLQGRRSHRDYSYADANEVESIALARKVLDSTKVPRVYFAAKVNERDVFVQERIPGVGLNIAWQYISQSQKSSFKQQVREILQRLRTAISPAEISRRSYVVPDPDPVKHRGIQELEREIIFAEDNKDPDLSFMHNDVSLSNCIVDNDRIVGLIDWEMAGFFGWKTAASVHAQIRTPKRENFTSLNLPEEMLNDILFWNDLYDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRY5</accession>
    <name>A0A9P4PRY5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_506578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2449102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="565" mass="60694" checksum="6B7463B46BFE002F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448166.1"/>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Enterotoxin_A"/>
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        <property type="entry name" value="Enterotoxin_a"/>
        <property type="match status" value="1"/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2448166.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU85</accession>
    <name>A0A9P4PU85_9PLEO</name>
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        <recommendedName>
            <fullName evidence="6">Siderophore biosynthesis enzyme</fullName>
        </recommendedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
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    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="1"/>
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    <feature type="chain" id="PRO_5040173147" description="Siderophore biosynthesis enzyme" evidence="3">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="20344" checksum="D28536DA3944AD2B" modified="2023-09-13" version="1">MKTTFLSLAALAATALAKTDLEGCTSSQTVAFGGASMIYWDPTNGEICSFLDCGGGRAPPKTTVPGCPQYEGSATYTPDFMPGWGEATATASFATASLASESASEKTSFEQETTQSAVAGESVPAYETRTGSASSTLVTSKAVLPSGAASGTGAAGISGHVTSKGNATASTGSPTQSLPVEATGAAAAFGVGSGLVGVVAGVFGLVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUC6</accession>
    <name>A0A9P4PUC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_194180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUC6"/>
    <dbReference type="OrthoDB" id="3740279at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="185" mass="20418" checksum="8413C790370CDC0D" modified="2023-09-13" version="1">MSFSSVMSSSSADSLGGVSTAPSSPPNGLPESHSYGCRTSHPPPQPNYKTLEKLLLSSVTLARSSFTRHSTFGIGTPTANYLSLHARVNRFLKKYRKHDFVQDGTYGYVLEIGILLRLVESALGLTHREITGLECEDPEKQQGDERQKLEKRCSRDVDYLVFGGRDLDVGRLPWNLKSEGGTQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUH7</accession>
    <name>A0A9P4PUH7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_351116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUH7"/>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="639"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115806" checksum="32BA39D7814989F3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUK7</accession>
    <name>A0A9P4PUK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_479577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUK7"/>
    <dbReference type="OrthoDB" id="10562751at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="175" mass="18759" checksum="9CB0F0276585C44C" modified="2023-09-13" version="1">MRRHVFVTTCKSARPQRATGRRDEEKLTTAVGRVGSGVELELGVELDVESGVELGVEKAASGAPQLLCSSAGVGTCQAAPPPRSSSPDLLSRLRRYPCPRTVLLAAHRNTLDLAVPIPPCPVIPLPLPLPRYLSNFDEPQSVHTSWLLPSAVVQEPPATMRAPATYTSPVPGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVH4</accession>
    <name>A0A9P4PVH4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_204551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVH4"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="64553" checksum="2022EFD754AF9D83" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW26</accession>
    <name>A0A9P4PW26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_438972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW26"/>
    <dbReference type="OrthoDB" id="5148443at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="258" mass="26838" checksum="0499EAE9B0FF89B2" modified="2023-09-13" version="1">MASCFVLRASCFVLRASCHDYMTPQYVHNVLEGAISSSSKAGWHLPLAFLATAFLLYISLGLGFSEWLTNSQAQPTNALDQLLSPATINALYEDARLQYVILRLTETVARVSLSYGDSFESGGLKDFGESLSAEVARMRAGERPTQNRKQLFGGRKDRRGFFSDVASFFGGGKGADASTTGGGLLWGLFGGGGNSTGGIGGLLEKGLSGITEKIVGGLATPAYFLGIGLGMGAGNGLNITTADQSKAIATKIASASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW72</accession>
    <name>A0A9P4PW72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_350673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW72"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="472" mass="47938" checksum="F150F5AEBD6DBCC0" modified="2023-09-13" version="1">MGKAHRLFHRRSAQVTANVLTINVEVVATLDSAGNVVGQATTTPGAGTTVIPPAVVPTVATAVTALPSLPSVPAVPPFPSDLNVPSVPAYPWPSGVPTEAAVDSTTQSAAVDTTTQSAAVDNTTQSAAVDSTTQSAAVDTTTQSAAPETTPVASLSSLSSVGPFPTVSGFNSTTSITSLSSVSSSLNSTSSTSSSRSSSTVGGGGAGGFIDPAGTSAASTPTVAPITDAGSSRPLETPQVVGTVVGSLAGFALLLWLMLFLVKRHKQKQHGGALQLTGDDQTDRETSPPMAQNAARTSFVPPSFLNRFSGASRSTADTSSTGEKSFQRISGRKLPSAFSEGMTSEQFAAGRGEGTLSGSSFYHDDKGWYGGAGVISKDFGDAGFAKEIGETSNSGAMGTAARVRPSPAQTPVIHHAADDVPFWGTPPRNGGDTLSPPLTPNPDFPPRASLGRSHPSRDGSTFSRSSRFTENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWL5</accession>
    <name>A0A9P4PWL5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ISWI chromatin-remodeling complex ATPase ISW2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_502499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWL5"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18009">
        <property type="entry name" value="DEXHc_HELLS_SMARCA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044753">
        <property type="entry name" value="HELLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="241"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="670"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="516"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2450146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="915" mass="102403" checksum="54F0517CB11FD1D2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX43</accession>
    <name>A0A9P4PX43_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_479096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX43"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2452086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="479" mass="53840" checksum="B6B153385E8CA36D" modified="2023-09-13" version="1">MPASLEPIKAFKCTFTGCAASFDTEKKLIGHKKDSDEHDYCSKCNLDFESYEDLARHKAFTPDKHGKACRLCGEEFKSRSGLERHTELAHKVKQKLPCIGCGEIFPTPALLIEHLEFGHCDVISGQSFMGHVVHCHLVAKLLAGGEAHNRFMQKISQYDASLDHEDEGGVGIENVLEHEDEDAKAVNHPAIQPDSVQDDVPHTEPWPALSAQGKDATRSSTITSRMGRMSLGGSDADTVVSSGSHTMQDSAAPNQSSRRQVKAWGGRSAKELFPQAKLTAAPEKEFSIEAVDEKMEHDHGANIFNTRFWDPLAREWSPDRFFNGLIEKYFCPFMCEQSFNYVSELRDHILVDHRVSRAKCPYCLKYFDSITALMGHCQSRGSKCQINKADDFGKFLNRLTGGFLSVEEKVRPDYIQNETVNVWNPETREMEKYTPPTVKYLEYTTSKPMDWKEPTKVAAQIGGGSTSGTFNYRNQQARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX99</accession>
    <name>A0A9P4PX99_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_479974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX99"/>
    <dbReference type="OrthoDB" id="3787153at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2450918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="342" mass="38508" checksum="D7970287ADC7DADB" modified="2023-09-13" version="1">MYPHPSDPFDDDSEALLKSPPQPSSAPRTYYDIPPQTPKPRSTFRNALRSSPPILAATLWLSIMSYFFHFYMTLPKDAQGHLPRIGEAYSTFPYISCIGAVRLTYFRGFACIVAILVTLSFFLDFWMGRHVRPGRWFRRAKLFFGTVSSVFLVLLSFESVNNRNHLHLIFTSIQIWCMGGAKLSDYFLHRHLRKCDRKRLIRCLQISKLWKRVVGIAAMPTSLTTMIGIYGCSMPVGLLPTNATCYKLVSFSAPCEWALAVCWISYLCVLGYDLYHAETVAAKIIAKTSQPGAGHGRSPSAEMRQLKLARVVGGDDDDTSYKSESTVAGKSYTSVRLEEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXB5</accession>
    <name>A0A9P4PXB5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_450669</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1051"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="471"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="627"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="746"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1362"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="770"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="825"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="899"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1367"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1442"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1080"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2451980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1474" mass="160246" checksum="9C64DD208D53E0A6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYB3</accession>
    <name>A0A9P4PYB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trichome differentiation protein GL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_152774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050891">
        <property type="term" value="P:multicellular organismal-level water homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901002">
        <property type="term" value="P:positive regulation of response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902584">
        <property type="term" value="P:positive regulation of response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902806">
        <property type="term" value="P:regulation of cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000037">
        <property type="term" value="P:regulation of stomatal complex patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000355">
        <property type="entry name" value="Transcription factor MYB124"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2451109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="403" mass="45418" checksum="363A30E0BBF3535B" modified="2023-09-13" version="1">MVAHRRGPWSQHEDRYLIELVGRNGPHNWVRISQEITTRSPKQCRERYHQNLKPSLNHEPISQEEGELIEKLVADMGKRWAEIARRLQGRSDNAVKNWWNGGQNRRKRNPERDQPSHPQMHHPQAAYHYPAVAHPAHHEDEAHRLSYSSSRRASLNPPMHSPHALKLPQPQGFEPYAGTRPAPLQLQSYPSHTARGRGIETPMPSPSGYSIVSADGAPSLITDTGSESRSPRGAASPLDLTLAPLVGSREERRNSCTRYLPHMGFASEDDDHTSYDHRRGSVQLPPLVGAENRTLTPFREPVSKQVYRAERPQLLTKPTHQLVHHHSLPYSAPLPEQRPLPHFATLAESGRVPLPSPMNTSPSSRHLPSPFSRAVQPTETRSAPVSPQDKAQDKRMDLRSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYC8</accession>
    <name>A0A9P4PYC8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYC8"/>
    <dbReference type="OrthoDB" id="3680973at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="401" mass="44961" checksum="CFF85017C1DBD804" modified="2023-09-13" version="1">MARKLEMRMETDKGRDGNAAKGSVPDGTVKDAQKTEGKTPQLATKKGLPDFVRNEILEVVRDEFSGAVHINLSERLKSEIAETVKESLLGVLDHKMTEIVKNETRKIISEEGLGGYAPRRKRRRVAEEEDVYESISEERLDTSKFPWPVSYPSQIPTTPMAIQDVITVDAYATKNHYSDLIVGRARLTFCLDPKIRPLVRAKLVPQTFETLRRYNVCMFIPSKYSKVPDRTGELQIPHDQVEFLPAFDGTTRQERSSKMAAALNKYGPQSSEFTIVDTYTGSGFLDWDIIIGHARPEVCADPAARPLVRASLTTDDKVVAYMPARYGSDRNRIDGELGVAIKDVKVWKEFDAPVESKRREMIKEALVRNRNDRLGKVCPGASTERGTEEVRQGGGTEEVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYR2</accession>
    <name>A0A9P4PYR2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_426229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYR2"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000014">
        <property type="entry name" value="Probable acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000027">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="124"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="237"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="400" mass="43174" checksum="B0959C275D33DCB4" modified="2023-09-13" version="1">METTGFTETQLEVREAVGAICSRFPNTYWQERDQSGQDPKDFHAALAKDGWLGIALPEVFGGSGLGISEATMMMQTIAESGAGMAGAQSIHANVYATQPLAKFGSQAMLEETIPKIVSGEWRTCFGVTEPNAGLDTLRLSTTAKKMDDNTYSITGQKIWITCAQVAHRMILLARTTPREEAAKPSQALSIFCIPLDRSAPGLDMRKIGKMGGRAVDANEVFFDGYRVPASSLIGEEGQGFKIILHGMNAERCLLAGEALGLGYAALTKAAAYARERTVFNRPIGSNQGVAHPLADAYMRLEAAKLATYHAARLYDASKDDAGIRQDAVGIAANSAKYVAAEAAFNACEKAVLAHGGMGYAVEYDVERWFRECLVPRIAPVSREMILNYVGEKVLGLPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U620</accession>
    <name>A0A9P4U620_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_526789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U620"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="300" mass="32198" checksum="050704C84C369C66" modified="2023-09-13" version="1">MSAEFDPNVLTAPSQLTKAMHRDVYPAIDPKKLAPLASDKVIIVTGSAGGIGYAVAKTWTEANAKGVVLVGRDEQKLASVAQGLKGNTLVAAGDVTKEEDVKAIFEKAIAKFGAVDVVLNAAGILNYGTIGELEPSQWWVEHEINVKATYLLAHYLHNFNKDRTATFINLVSLGASMTNPGLSSLSTSQLAATKLGEHLDLELTNVRVFSIHPGIVEAKAGRGTVIDVMTPFAKDQPELTGAFSLYLLKPEADVLRGGYASVNWDVEEIEKHADEIKEGRLLRLGHINAKVGPNGHPWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6Z4</accession>
    <name>A0A9P4U6Z4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_423766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6Z4"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000789">
        <property type="entry name" value="Transcription factor (SPT8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="131"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="498"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2438517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="667" mass="71144" checksum="438B36544F0AAB3D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U739</accession>
    <name>A0A9P4U739_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_458434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U739"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2438788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="86703" checksum="A38788128838AB5C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7D9</accession>
    <name>A0A9P4U7D9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_89037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2441094.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="524" mass="57963" checksum="4839024960658DCC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="72" mass="7391" checksum="D259B09DE0162960" modified="2023-09-13" version="1">MVKCPECGAGADLTKDGSYAHCASCNTIFEPGKEGTQYRGSGSGSGDKDESSGTSKDAQPEEKKDEGGKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7H8</accession>
    <name>A0A9P4U7H8_9PLEO</name>
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        <submittedName>
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    <organism evidence="2 3">
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="305"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U822</accession>
    <name>A0A9P4U822_9PLEO</name>
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        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor 38B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_395445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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            <taxon>Pleosporales</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
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        </submittedName>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2442145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9S1"/>
    <dbReference type="OrthoDB" id="3780500at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="103" mass="11996" checksum="7E4BA1588EF0ACF5" modified="2023-09-13" version="1">MKPLYGLSQQPSAWRISQRGRRRHDPALRQSDPELQDAGPIEIRERFNKWLKSGEEAPDDSYRYMACVLVDSATLNSVDRWMKDKTLEDDRLTLFDARGRTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA29</accession>
    <name>A0A9P4UA29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyoxalase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_521472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA29"/>
    <dbReference type="OrthoDB" id="3340372at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39175">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39175:SF1">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15108" checksum="57E30787B3116E31" modified="2023-09-13" version="1">MITGLHHINLVVPPGTLEQANDFYGSTLGLTPRAVPQLQRETLAWFDIGTSGQQVHVAFGKPEDFAHTSSRHPCFKVGGREALEALQGRVWGHFERGGESAPKAADEPGEKNSGAEGVEYPTRFFARDYAGNRLEFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC16</accession>
    <name>A0A9P4UC16_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">P171DRAFT_433025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC16"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="53"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2443858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="277" mass="30108" checksum="2D26CD659A1B038F" modified="2023-09-13" version="1">MAPIQDGSVDDLKHKVSTLEARIAELESRLGGGQGSAPQAQDGVRMILMGPPGAGKGTQAPRLKEKFCVCHLATGDMLRAQVAKKTPLGREAKKIMDAGGLVSDEIMVNMIKSELESNQECKNGFILDGFPRTVTQAEKLDDMLTASKRPLEHAVELQIDDSLLVARITGRLVHPASGRSYHKIFNPPKSEMKDDVTGEPLIQRSDDNADTLKKRLGTYHAQTAPVVSYYQKTGIWTPLDASQEPGQVWKSLLKVVDNKATISGRTGSLLNKIGLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC70</accession>
    <name>A0A9P4UC70_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_432126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC70"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="37124" checksum="986D92C407A4462F" modified="2023-09-13" version="1">MSKATVLISGLNGYIAAVTAKQLLDNGYHVRGTVRKSSSATPLVEGPLKAYAESGALSVVEVPDITVPGAFDEAVKGVTAIAHLASPVSFSFTDPEPVLKAAVSGTTTILNSALKAGPQLKTILLLSSIVAIMSGDQPPYTFTEKDWNNWAEPIVAEKGKETPGVVTYCASKAASEKVFWKFRDDNKPSFTLTSLNPVYVVGPPLIAPKTPADIGETLGAIWNIFRGGDLPTEGLIIGLGTVVDVRDVAAQIEHIIAHPEETNGERYLTSAGFSTAQATADILRKAFPEARERIKEGTPGQGYNSDFTLADKTKARDADGSKAKKLLKGGEYIPYDRSVIDTAKSLAHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCE1</accession>
    <name>A0A9P4UCE1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_289953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCE1"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040254580" evidence="1">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="141" mass="15190" checksum="01DD9589E4BD7BFB" modified="2023-09-13" version="1">MLLPKLFLLPAAVASSVTVYMHSVPSTSSPQTAVIPSPIPLVQISYDADQTTGTVISYTPPQGSYASDHLLRIGLHDTKAGTWKGHVGFRTTVKEAGDGDELEVELVRREAGPKPVLNKPVVLNADGRIDSKEPEKTFIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCT8</accession>
    <name>A0A9P4UCT8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCT8"/>
    <dbReference type="OrthoDB" id="3934095at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="192" mass="21713" checksum="97E9BC309BF9A212" modified="2023-09-13" version="1">MEVTERLVNSPTPPLPVRNPNHRYPPRKAAFAVPNSSAKLIPKPLFSKRSRLSPLEIHIEVQEFPDWSSRSSSQSSGPPSPTFSFTSFASYASSATTVSGPGSIRERPASQEYLFPPSDICNWGNEWEPSHAPKPRLRRIKTPKKETLRDLRAKGSDVCLQRVYEQQLELYLNGALFPRTKWKYGLSCVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD69</accession>
    <name>A0A9P4UD69_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_431668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD69"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="307" mass="33540" checksum="D5CE9F3E89090002" modified="2023-09-13" version="1">MSSNIAPSRSPGPSLAQVHPPPSTSPGNSSTTTASYSSTGASASSTTTPSPNPFVFNAAASGKETAGSKTKNTGTPSWLPRGQRLQLLKGPSIEIVVGSDTNVSKETWCLPMSLISHHSPFLKAACSHDFKEKEENRITLADEDPRIFSLFVEWMYYDTYTLAFDAVYVADTDAKAWILGDKLMSTAFKNFALGRTYDAHQIGNLLGGSVTANLVAYVCENTVEDAKLRRYYIDFVVTHFSNIHRVSGTIEEWDSVMMEFDDVRKALFNAMRSSSQFGRVGTRDSYLEAMSSSKPNELVGKEVELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE07</accession>
    <name>A0A9P4UE07_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_520130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE07"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="263" mass="29675" checksum="1C0B73FF6FC4729B" modified="2023-09-13" version="1">MLSPLFTLPHTWKLQKCAKMLKPVVTARLQKRGESKGGSVEGDRPDAMDWAIEQGAHDPQLNDADVLTEELLHNLWPVNSAPGGLMMPIVYRLCLYREPLKKKAQAAMAEHGWSEKALSKLHMQDSFVRGINRLYPTGPVTCSRTVCDTDSFVRPLEFDGFRFKDACGENEVVKVSRHWTATAMATKNLGWGYGNHACPGRFFTVREIKLMLTKLLLEYKFSWKQDSKLGRPAPVNVEGQFVPNLSQTLLSGTGFAERLYSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE50</accession>
    <name>A0A9P4UE50_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_428590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE50"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="70" mass="8036" checksum="053BEC5D92F27407" modified="2023-09-13" version="1" fragment="single">MHLMYTLDAQGKRVYTLKKVVDGRIANSAHPARFSPDDTYSRHRVTIKKRYNLLPFQAGGAAKKRVAEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE61</accession>
    <name>A0A9P4UE61_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_381271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE61"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="268" mass="29414" checksum="65852AD5F9EFB178" modified="2023-09-13" version="1">MLLPRILAPVRAAAKSPLIPSSRVLDVLRHPNGSAAHAPAPALSFVRHASHQAQGRANGAKDGPGKRLGAKKAGGEYVIPGNIIFRQRGTAWFPGENCKFGRDHCIFATESGYVRYYKDPLLHPKRQYIGVALEKTDKLPYPQNAARRRRLGFVAVQNEPQPKELDGQTVVADLQVGGATGSETSITATARNATTLTVGKGYAYRHANYDIGRVAERANVQVKEFVPGDRWAAWRKSQARKKRNEEAKKLRNAGKKSAKPKARKRRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEF0</accession>
    <name>A0A9P4UEF0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_244272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEF0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="85" mass="9426" checksum="441DAEC08E6A0FD8" modified="2023-09-13" version="1">MRSVHHTHAHTSHPPMHSDATSGTPTPHQSCEASRKLALIPARRQVSERDGGDRKQPSEPMRPAKSTCRQRLPVPTVTAARERFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UER4</accession>
    <name>A0A9P4UER4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_383495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UER4"/>
    <dbReference type="OrthoDB" id="3787728at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="432" mass="49369" checksum="11CA0BBFFA5B3C96" modified="2023-09-13" version="1" fragment="single">MSTPKHEPNRPPVDQDIEIRIRDFGNFTIAALCNFTVLVVHVGMLWFSTKAVPSTIPMPFPLRWACIVCLYLKARNTWLFQSIIAIKRTKMSDIEHEKRSRNRNSGSHSTNLEDWILANFCIIVGLSTIGFVAWYWVEVIALTIWLFLYWTCTMGGLCSLFWLLKRTIRFYQKVKAVKHEAWGIIVGVYVSRFSAKFEMVEANGVLGQFLDFVSIPFLILQFLLDKIGFYIGRGPLSGESDSHSHHRNDNDEAFYPPSVFEWQPNPVIHPHLRGEHLQSLNHDPSVAESNSDCHLMNTTGEAGRSSPEIAVDFDDDKGIPKNNQMYPGAPRYTGPATMSAILSSFACFQCTFVAKKRFELNKHVTQTHNHRFKCVYHGCGKTFGLRANFERHEATHTDRKGYGCPNPWCKTPGETFTRNDNLKRHMKLCVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF12</accession>
    <name>A0A9P4UF12_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_238621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF12"/>
    <dbReference type="OrthoDB" id="5040840at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="158"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="481" mass="53331" checksum="D74721374B2764B3" modified="2023-09-13" version="1">MQSSTSSVTDSPSSTISTSEVDEVLLARWKIQMRWRKAFLFARTGNPNLGDVLLGDIGKLRESIPDDTIVVEYALASTPPCGVMTIVAASDGIRVAEWKQTDAIAIQKSIEDLRKSMDVTQARPGSTGAYPFSINTTSRSADRPSVPQRNASALCQERLSNLLYESVARPVKPHLKGMKKLIIIPSGDLANVPWSIFFNFPITVVPSLNIWNRLQTQAASAEKRHPKVSVVSNAPIDHEKKRKNLPAIRDIPYSRMEALAIARGHHKGLSPFIADGKDREEFKEETKGAHILHLCAHSTFDPKFPSKSSIQLFHEPLTMSDWRELSISANLVVFSSCLSGISKAYDSGSAIGFAHTLLATGTGAFVGSLWPVNDAATFLLMVMFYEELRKSSPPADALYAAQMRMRRLTEGDLLGIIDEVQQHFLHGDADEFVLEPMDLIDELKEQKIMELREERYWAAFVLTGYGSRELYHASLETQGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFA5</accession>
    <name>A0A9P4UFA5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_334333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFA5"/>
    <dbReference type="OrthoDB" id="5401779at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2447308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="106" mass="12070" checksum="850DBDEC2ED60539" modified="2023-09-13" version="1" fragment="single">GMVVDSVIWSLPHFVVWQLQLRRAHKIAISCIFALGLLNILVAVFRIISIVQVDFRGDMTDDLAAAMAWIYAQLSTAIILACCPQLRPTFEKTIPRRFTRIRRNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFB1</accession>
    <name>A0A9P4UFB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_211057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFB1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="7">
        <location>
            <begin position="220"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="314" mass="34477" checksum="2387A9EFBC87F817" modified="2023-09-13" version="1">MDNQCSVHLGLILQAEMEQDVLSEAVELAKDADLTVVFVGNTTQWETEGQDLSSMDLPADGSQDNLISSVAAANPNTIVVNTTGVPVELPWLDKVSALIQAWYAGQKTGNAILDVLLGETSPSGKLPISWPVRYEHTGCHGNFGLDSYESREVEYVEGVYVGYRWFDKLWGSEKEVRFPFGHVLSYTQFDVKNAKVVDGAKEVVTVTTVVKNVGESAGEETLQVYVEPPADDGVIKKLVGFAKVDLQPGEERDVEVQFKKQDAAYWEESLDQWKVSKGIYGILIATSSAPKDVRARLEVVVDGDEKSRVNTAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFP1</accession>
    <name>A0A9P4UFP1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Mre11 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P171DRAFT_408114</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 17" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="20">
        <location>
            <begin position="297"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="530"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="905"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1040"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1217"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1693"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1115"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="589"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="905"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1222"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1256"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1301"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1339"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1418"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1711"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1732"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1771"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1813"/>
            <end position="1840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2447713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1840" mass="202343" checksum="308C26601FCCB893" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFV1</accession>
    <name>A0A9P4UFV1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.1.99.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_428522</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="11"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFV1"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="16">
        <location>
            <begin position="126"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2448445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="558" mass="61162" checksum="A1474D1C07509CC4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG04</accession>
    <name>A0A9P4UG04_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_479670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG04"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040168763" evidence="2">
        <location>
            <begin position="26"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="416" mass="44056" checksum="C69E0D6188E42DBB" modified="2023-09-13" version="1" fragment="single">MVSSRSASTMHMVASILLISNVAYASVLPPNQPYLPGTIAARAPSEDVTNTQDLAEMIDTLSAKKEGKKFFKELGQFLSDFDAIDVFRTMLGGLLGFNVTDRTVSSWLATTVSITPTPIESPLPVVVPTSKTTSTEKVTTKQVKTSSTKASSSKKSSSSKKASSSTSAEAVFSILPIFPTEEPLELTGLAPTALATPNHIIFTPGAAVSFRAAVSADAEVSVDVLPTGPFIDIFDVSSIEVPEETKALVALSEQVNATAAPNATAFGITVIIEPDETASILPFIDPEETAYILPFLEPEEDLSDDATFSDVPSPTYDISITGTFGLPTAQLTLVAEATELFEPEDTFSILPFFSLGEGISDNVLPATAEEIPPLETFEVVTIPVTDVPGATLLPVQTEEIFSILPFLEPGENISDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGH4</accession>
    <name>A0A9P4UGH4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nonribosomal peptide synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_516953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="809"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
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            <end position="1454"/>
        </location>
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    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1449"/>
            <end position="1525"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1976" mass="218205" checksum="4A0DF86870A307A3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHC7</accession>
    <name>A0A9P4UHC7_9PLEO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_469285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2449137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040418897" evidence="1">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="143" mass="15826" checksum="080D3BB9D4D95D3E" modified="2023-09-13" version="1">MDFYALFLSLVALSVSVMASPTSAGPHVSRLEERANELARAPQPIPFIPNIDPATKALFKREDKEWTFGGYQTVKSSGKDVPLKAEFNETAGSSWCNEIDGVGKGDARDNTMTKAHVDSHVSWTNPGPENRPPEYVCFFYESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHT4</accession>
    <name>A0A9P4UHT4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_479643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2450560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHT4"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="757" mass="85479" checksum="DADBD97A9923B9B8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHV6</accession>
    <name>A0A9P4UHV6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_203377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHV6"/>
    <dbReference type="OrthoDB" id="3787241at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17158" checksum="B304F19FC9BE43A7" modified="2023-09-13" version="1">MHFEYFRLICAPEFSFVFETDTWSNIVLQAACTNASFRRIALAVGALSRSRYMKSSRQTAERYALCQYNMVIRDLGLLNHSPEIALRIVLACIMLIVLEFLLENYDRIQIHLRSAVSMLSALDGQFETETIFYVQALAYIQDMMSCRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIB4</accession>
    <name>A0A9P4UIB4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UMTA methyltransferase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_459949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIB4"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="292" mass="33124" checksum="343720E642386ABD" modified="2023-09-13" version="1">MESGNSMENGDVPEGHRTLKSANQISNTYSQIEGGTYALKRDFNASTRLTAQHYLWKEALGFNLHPEIAVKPDWRVADVATGNGIWLLDVARSLPLSARLDGLDISLDQCPPDAWLPENVELTTWNIFEDPPEGFVGAFDVVHIRLITVAVRDNDPKPMISSLKNLLKPGGYLQWDEVDSVDWTIKCVHRSVQTDAMRRLFKQLCGTDDWKRDMVQTLNRHGFENASVYRFNYGKSMARFWNDMYFSTWEEFAKVVLKDPSGSHQLGVAAMDEVRNGSALFCPKLVWVARKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIP7</accession>
    <name>A0A9P4UIP7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIP7"/>
    <dbReference type="OrthoDB" id="10413099at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="241" mass="27238" checksum="3B182A996ABE241C" modified="2023-09-13" version="1">MPMFPQPNQNTMFQQPTNQGYTFIDDDLQILGATSNTNSQDSGSFMNNGSGLFQPNGQFHMNNNAGFQQNSHPQTGIAGGAYLHNLQQHGTQMYTSSQQTAIPRPPPRAASRSPSRSPSRAGVRGPMRPNQPKDVPDGGYRNVVCKNCHHEWWNTWCDDEKQDTCYNCWKSGVECVRPQCPDFQNCTNPRCKGAHEQNGFLNTVEMENKRSMKRKNRMTEDHEEPPRKRMKEQGGDSGWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJG8</accession>
    <name>A0A9P4UJG8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_438378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJG8"/>
    <dbReference type="OrthoDB" id="3798591at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="258" mass="28325" checksum="2F38DD20CC1F572A" modified="2023-09-13" version="1">MAPKRKAPKKKTAKTARSRAPTTPHKKTVQPPAPGNASTPSHPHPYTHLSFSARRTLDATDYGFKNTPIPATTTTLPRLRLLRPTTTNLPDNPATVTPLMQIMQNKLFHVREYFLPEVKALIWGRTDRGPRTASEKALLAEAARGIGRGGVGGGLGISPCAVDCVRLILCCAVIFEMEDREGKGKGGEEGFRVEERKADLEFRAEVWEKLRREIGEQLPGDRKVREERAEVVLRKVFRLACEEDGSEVVGVGRGVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJT6</accession>
    <name>A0A9P4UJT6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_515925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJT6"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2452033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="417" mass="45309" checksum="972727738D723762" modified="2023-09-13" version="1">MPRDPLIGLVGKPSSGKSTTLNSLTDATSKVGNFPFTTIDPQRAIGYLQIECACKRVGLESKCKPNYGSCVDGRRSVPIELLDVAGLVPGAHMGKGLGNRFLDDLRHADALVHVVDVSGTTDAEGKATRGYDPSQDIVWLRSEIVRWIQGNLMEKWGSIKRRHVAIKATAVETLQNQFSGYGSTSAVVARCLDKLALKEPLQDWSNETIESVVHAFTDEKFPTVIALNKIDHPDADKNIAKIAKQQDPQSIVLCSAISEVFLRKLAKQGFIKYTQGSEFVDTREDLIEAGDPDGGGLKELDEKLRTRIENLKDLVLYRFGSTGVVQVLSRAADLLGLVPVFPVRNISSFSSGSASSTAVFRDCVLVKKGSTVGDVYKKVMGDAPMAYVEREGGVRVAEDDLVKVGKNDILSFKVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJZ0</accession>
    <name>A0A9P4UJZ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_376271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJZ0"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF188">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2451822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="506" mass="57296" checksum="333FFE78416A4470" modified="2023-09-13" version="1">MWFIYAAAAGALLRLLYGLYSTLLDPLRDIPGLFPARFTKLWYLASVYKGAHEHDAIALHRKHARPGEHFAPIVRLAPNMYSIKTPEKAVYGIGSKMPKSAWYDGWRHPSPDRWTVFTDRNIKRHADSRRVYAGLYAMSGLLSYEAYVDDCTDVFTRRLGELAGGQAVDMGRWFQCYAFDVIGAITYGKRFGFLDEGKDLGNTMRALDRSMLYSTLVGIYASLHPYLYPLLERLPSSGAAGRAYLMRFASAALAQRRGERARGRKERRVGEPEDFVDRMLDMQEAKAGVTDYHVFALTMSNIVAGADTTALSVSSVLYHLIRTPGALEKLRAEIEENVREGKCTPDRMTFKASQEMPYLQACIKEGLRLHPGTGLPLWRVVNEGGATISGRYFPAGAEVGINTWVAHYDADIWGSDVSVFRPERWFEADAEQLKVMEAHYIPFGLGSRTCIGRHIGHLEMSKLVPLIVDAFDFELEATGRWKTKNLWFVKPVEFRVRIKTRRREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4J5</accession>
    <name>A0A9P4P4J5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_399978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4J5"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000043">
        <property type="entry name" value="Protein transport protein sec9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000048">
        <property type="entry name" value="Protein transport protein SEC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="345"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2437311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="408" mass="44111" checksum="DA79992B43B5D539" modified="2023-09-13" version="1">MGLFKKKNKETDAGANPYAAPAKNDPYANAPPPAYQRGNDSFRQEKTPAVTGQGAQFGGRGYQSSGSGSGSYGASGGYGGNQYGGGADQGAPRRAGGYGGLGNSDPNLDEDRSALFGGAAQRQQKAPQQQQQQQPPQQDGGYGQPGGGSYGPSGVSGGGYGAPGGYGSGPAYEDRQLTAEEQEEEDITATKNEIKFMKQQDVSSTRNALRLAQQAEETGRDTLARLGAQGERIHNTERNLDLASSQNRIAEEKARELKTLNRSMFAVHVSNPFTSNSRREDRDRKIMENHQNERAQRDATRAAAWQSSARQDEYKRGVQGAGNTGGKSTLADRAKYQFEADSEDDEMENEIDNNLDQLHGAAKRLNALGRAMGQEVDTQNKHIDRITQKTDKVDDQVAMNRARLDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P523</accession>
    <name>A0A9P4P523_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_182988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P523"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="102" mass="12107" checksum="52AE313F039C6758" modified="2023-09-13" version="1">MNRLRGRDMTKIRVSKYRCLQRCRSRHFRSHSAILRERYALACCSYCQIAMKELPCKTDIFFIHPVRSPIKDDDTKVFIIVDEFGKEVGDEYLLCAHHLGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5P4</accession>
    <name>A0A9P4P5P4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galactose-binding like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_333412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2437911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="132" mass="15200" checksum="273F3FD0C68D4D52" modified="2023-09-13" version="1" fragment="single">REISTLASWTVSSSKPGCSVPQLRHPSPNLFWQSDGPQPHYLNIHFFKLVHIVGLRLYLDFEQDESYTPTRIVLLAGSGMNDLVEWGEMRLENPRGWVKVNMPTLRCHLVQVKILENHQNGKDTHLRGLQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P703</accession>
    <name>A0A9P4P703_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_423985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P703"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="8">
        <location>
            <begin position="132"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="572" mass="62458" checksum="D06B69EEE22DC9F6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P708</accession>
    <name>A0A9P4P708_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P708"/>
    <dbReference type="OrthoDB" id="10260248at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052738">
        <property type="entry name" value="ABC-Tungstate_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945:SF1">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP" evidence="1">
        <location>
            <begin position="41"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="303" mass="33609" checksum="892412F8F60E1E90" modified="2023-09-13" version="1">MMRTAIVSHGDVDRGPTEIYGHGELLFRIGNGGAGALGLIRALAEDYLATFPSPFSITWTCNHSRNTQLALLRDYIDIALTYERDQEELAASEGWSATSGCMFHDHFVLAGPTADPAGIRHAQNLKESMQRIAEKICLFHARADSSATMWKERSLWAVAGIKPWEDEKATTWYRTSLLNPADTFQGADKAGAYLLTDRSTLLRQTGMQSIREATVFFEPEQENDVLMNSCYASYRTGVSTGKAKAVNDFLTYVRSERGQKAIGDFGSTSVGIPLFATLYERLSKSKLKGGRPRDGRWLQPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P726</accession>
    <name>A0A9P4P726_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_436993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P726"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000031">
        <property type="entry name" value="Ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000035">
        <property type="entry name" value="Ubiquitin ligase subunit CulD, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="485"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="869" mass="99011" checksum="8A8F0021191B29D6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7M2</accession>
    <name>A0A9P4P7M2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_448876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7M2"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="207"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="765" mass="85877" checksum="2F4D8DD9F49C83DF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8G5</accession>
    <name>A0A9P4P8G5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI transamidase component GPI16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_436079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8G5"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040306233" evidence="2">
        <location>
            <begin position="20"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="583" mass="64947" checksum="F038E2B31229B23F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8H3</accession>
    <name>A0A9P4P8H3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_502328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8H3"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="178"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2439167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="428" mass="46913" checksum="462D96598AE65216" modified="2023-09-13" version="1">MPRTTDNPDGYTPALQRVIFEDPSTSTRELFTKHLTDVPMPSTPAHDDWLKHATLHQVLLEKLALHPAMAPNLQQTYNTPANNKNNVYFMWDFVGRTLGQLFRMDPELPRGIDGPMEDVVVRTTTACNLILDVQKGMLDEMTESQYPEQRGKHPAFGEEILALAREMSKLKDSIGEGCEVCARKTARDGSGALFKCGGCKEAQYCSVQCQKRDWKRNDHKGRCKNFKGRAAAAEELQKEWESGKLYEDLKGEGGVGAGVKEYVKEHPQYADQQTHLPHSEMPSPDNPSSPPKPSNYKPPSPCPSSPKSSHPPAPNSHSPRPVSQIRRPRSRHHPAPHQLPRRDSRLVRNSTTNIRFLTLYFLVRLLVAVAVGELDAATNTKGGDRGFPGDGDGGAGGAGCGCCGGGVHSEGSFEGPDYGRVEGGVTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8U5</accession>
    <name>A0A9P4P8U5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_422239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8U5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="157" mass="17010" checksum="DE4E0606E6D1ED01" modified="2023-09-13" version="1">MLTHKLTWTGSGRALLIGANRQISERNNNVENGRQTVGGLNFTSGEPHSCSSSLRCQGPEIGITTTFPHLLTAAGSHPCKPGKKRGSIRIPQLGPYPDGATYTVRVTQGCAYVPQRGATLNMHMESWQQCMSANTPEDYTDSRRAEATGSKEKKSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9D8</accession>
    <name>A0A9P4P9D8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_446778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9D8"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31512" checksum="FBF56A37C21E477D" modified="2023-09-13" version="1">MTHPPYIPLQAIRTDSSLPYLLLPDTICEMFEEHFELRYDHTSNLYTLNESAHQKNQQHKAIVSFRIGYGEPDSNYYTKIVLPYDAFHPNICLPDSENLTRYFPLKRSSDGSFKLGGTFLQEAVIVDYERSNFTVAPAIYTDPMPDEDLVPIYNTKYTPPISILARRASRGDERVFDGAIAGITTGLIAFIVGAALGLCLWRIRNHRQQIPLHYEEAIEVDNSATGNEAKRYRISELDTLVPGSPKVPDGDCKTRSLRPFPSLRETEVPPQELYTPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA31</accession>
    <name>A0A9P4PA31_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_490310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA31"/>
    <dbReference type="OrthoDB" id="3664501at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="507" mass="57816" checksum="1E19470ABE42B7BE" modified="2023-09-13" version="1">MESQHSRLISLPREIRDMIYHEYVYSEEGYMYDLPSGKLRHASGALVDLNLRHTCAQIANETRGLALKQNTITFSTYYSDETSMYGARLEKLMKDFTLTKAKLLWYQPWITELDVFQELAGRYPNHTSLLLSHSMSGVYPRQPWGQAGSTRRRFVASALKRLAENPECDFKPDAGLAHDESTGDTDTIVWSDILPWTVPTESTVIDLIRKFSTRQRSYNCGGRVKHYISAAAMCIHFLSSITNEALLEIRNIRILEDHHAVGWAECHAQGLIPFCKKNPRLRIERKADLWRNLSVQTFHADMVRGVRRTYEDDILRSGVTSSAVITWIGEAIVLPSLGMPAGSFRLVIGGAHPREEASLLQHTLWDATIQEALESSVRRRFVSQSSPLKWRSHICYKFDGFPKALSDIRNGKSIVSFGCKVEQKSNIESIVEDRRGWSLTQWNDARAWDSPWDFAYPAALPRWNDILQEYKLDKAGVAYVGSASRCLLRRELPGLKDIRLSKKICSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA79</accession>
    <name>A0A9P4PA79_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_435095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA79"/>
    <dbReference type="OrthoDB" id="5338195at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="66"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="656" mass="71473" checksum="5CF9447BF966A197" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAM9</accession>
    <name>A0A9P4PAM9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7alpha-cephem-methoxylase P8 chain related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_124221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAM9"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33950" checksum="9DFFD44AA166F806" modified="2023-09-13" version="1">MATAAPRPTPAHELSGTTPSVPTSTDVNFQGLPIPRGPVKATLSFYKPPEDGSKPHNYVEPLEGVPQRNFGESLHDVTLNDLRGQEQKFSLNNNAFDTIQNVPSEEYEFQDDDQIKRVYYPEVEKLLLESVPGANRILLFDHTIRRSHPGANRAPVTRVHVDQTPFSAAQRVKFHLPDEAEKLLQGRYRIINVWRPLNGPVMAHPLAVADSSTVRDEDLIPVEHRYPDRTGETAQVHFNPTQKWYYWSGMKNEDRLLLKCFDSDETVGLWGRAPHTAFVDPRTPEGAVGRESIEVRALVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBI1</accession>
    <name>A0A9P4PBI1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_523989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBI1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="226" mass="25229" checksum="4A7C3813B0328DED" modified="2023-09-13" version="1">MGFDLPRTGALHSACMLLSPGRNDARLIPECLAICPSNLLLLPTIGTSTCLTTKDFHQSACYGPSFHATGVTEPRQVCMFVLSLLATWPRADSLACELDDDARKSLLDSYQPLYLREFLSSNIFHSFVCMEYGEALLTIYSLTITLIETTRAKLTTLHLESPYLHSMQPRSESLGTACTVPESSMSEHWCVIAPFRSFFLRDPHKPAMMSSGIKFFNTWFAWSGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBU2</accession>
    <name>A0A9P4PBU2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_488533</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBU2"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="132"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="444"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2440952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="535" mass="60754" checksum="42BC34E4A392AA4D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCX9</accession>
    <name>A0A9P4PCX9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_433138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCX9"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040114535" description="Trehalase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2442719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="668" mass="74810" checksum="9CDAEEA52D35EF6C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD23</accession>
    <name>A0A9P4PD23_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_363289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD23"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2442794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="435" mass="48431" checksum="8A78845BF3817338" modified="2023-09-13" version="1">MDRAEIANEKVVSSVSVAYGDVEPQGWDAQNTKRLLRKLDWHIIPFMSLIYLLCFLDRTNIGNARLDHLEQDLNLHGLQYNDCLAVLFPFYIAAEIPSNIMMKRVRPSIWLTFIMFCWSVSMVGQGFVKDYSGLMATRVFLGIFEGGLFPGVNYFITQWYVRKECGFRMALFFSAATLAGAFGGILARGIAEMNGVGGKAAWAWIFILEGLLSVVVSLAAYWCIYDYPATARFLTEPEREEVQRRLLAEQGYLSNDFNTKYVWQAIGDWKIYIHMFICMAGFCPIYSFALFLPTIIKTMGYTANEAQLMSIPPYVAACFFTIIASWYADRVGKRGIFMMSFQLVALLGFGLLCGSGKASVQYAGTIFAAIGIYPQIPLGMAWNSGNIGGSLKRGTGIAMQVMGGNCGGIIASYVYISRDGPRYITGHSILIGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD96</accession>
    <name>A0A9P4PD96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_496720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2441991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD96"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="502" mass="55782" checksum="7FFB7B437A8158D6" modified="2023-09-13" version="1">MTFLQYILRASPAEAAVEAPECAENDDEVYPVHAFDDPGRLEVIVTSWTLRFNDVLDEDKIHKSLAKLMEIGDWRKAGGRLRQKGKGQLEIYAPRTFTAERPALTFTSQTYNMAIEDHPLAARLPKASEKPHLYPAPRKFREFAVPPGAPTTLEDYLAGDVPMISLRITSFHNGTLVGLAWPHTLMDVMGQQALLRAWSLVLAGRMSEVPPMLGAKEDAFSGAVDTSKEVAEEYVLKPQIMKTWSLVKVLINFIWDLFWYETVETRTIFLPKQAVANLRLQAKKELAVEEELPGKPLISEGDVLTAWTMRAVASALPQPRSITAVHAMNARLRLRSLVDAPGLYVQNMVVAAFTFVEHSIAIGPLGPIALLNRRQLEEQATEAQVLANLRELQKQPPGRADPISMICGDPDALLMPYTNWSRADLIHAVDFSAAVIEEGESGFSRINPPGTMVCHHAAAMKQSPMERNFILVLGKDHGGNQWITASLLPPAWAKIKDEMKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDF3</accession>
    <name>A0A9P4PDF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_523808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDF3"/>
    <dbReference type="OrthoDB" id="3946796at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="738" mass="79757" checksum="9E3846965283B87D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDL6</accession>
    <name>A0A9P4PDL6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_416489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDL6"/>
    <dbReference type="OrthoDB" id="5140048at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="443" mass="53038" checksum="94A663F756799317" modified="2023-09-13" version="1">MARGNDMGKLLTAGGAAAALGGAYKLGEFMYKAKRLRDVGPANAVYVRLIGRVRSDLDEVRRLLAVKEVHDELEANPEKAKWVYGCMRDVRGALENITPHTERVGSDIEDGRRVGLRHRVYWLLSEKEKLENREKEVSIAHASLTEVIGYLTGLEPQTTKKSHDKHEKHEKHEKHEKHDQHDTHRDVHVDKHVDIDIDVRHERHEGPHRHEREVWVERDEHGPKRVVEEREEWTEREIVRRGPRRVEEHIVEHEHRGPGHYDVRETWVDEHGRPNRYDEREVFEQGRDPRHESHYTAHHQDHHHDDRHVERGLHVERDPRDPRHVEARYYERGPDRYEEKRYEERRFNEPLGRRPETLEDRIPERETWMHSENRRPAPGQYNRYNDYAEYGAPQPIGAANYRLPPNPEYEREVWVEEKEDYRYDEYGNRLPDRYFPNLPRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEG9</accession>
    <name>A0A9P4PEG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_434326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEG9"/>
    <dbReference type="OrthoDB" id="3365267at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="181" mass="20192" checksum="7791ECF141B8F63D" modified="2023-09-13" version="1">MDSSLAAFRDGRSGQLRKLAEEHLQHDLNQSDRDIIKRAGSKVSTHAKVGTLLGVGFGIYCAFRLRSMRLSYFNAFRAMEKPVEVRFADGRTEPIPDITDKLAPSKWSDAATYFFFSLGGLFFGGEVGFLSGTASASRTITKDPEAKGRIEKAFKNYRIDALKQEIQQLEGKSTFEHLFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PET6</accession>
    <name>A0A9P4PET6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_47912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PET6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="213" mass="24301" checksum="E8E3D4C386E2D42F" modified="2023-09-13" version="1">MKVPANMARIRTPQSISEATLVGHVSDQHKLPLAHIPLGCSCFLHAPGSRLASPHFPNHWIYLPSASYRTMHEKHTVWRIRRISLPMLEKGSLWRAEVDRTRRMSIQKVNAVSSARPGSTTHRCWHTHIQLCRVLQTHPGSSHHDSKLRHDHATIMEKSCCRNASPPVSPFHIFLEDPIARHVKTSGEAPTERDKPYHVSHRICFRHHGLHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFU3</accession>
    <name>A0A9P4PFU3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_29801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFU3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="165" mass="18855" checksum="7659F50F224ACB81" modified="2023-09-13" version="1">MARVGWLVSFWPAGRRLSPLSWVHCQRARVFVVARCCHLAYPVPSQTSPNSLSRLQFPTAPWRVRSTRTREMVHRLKGSVLNCNYKRVTYAWQVRKTLPPRLPVPSSPGGHVEAAQLPTAATQAEQLRGRGIARCDRALSHHDEELTEPQLRCLSQVSRKRDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG38</accession>
    <name>A0A9P4PG38_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG38"/>
    <dbReference type="OrthoDB" id="4821062at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="1">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="618" mass="68160" checksum="06FA4AC3A45DB58D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGY2</accession>
    <name>A0A9P4PGY2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenine nucleotide alpha hydrolases-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_431670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGY2"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="120"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="445" mass="48258" checksum="A3E5E2373EBD3AEA" modified="2023-09-13" version="1">MSGVSPTSQSRNASPAPPRPRSSTPGQTVSPQLLPAAGAGSEDPSRRPSIQFKAHADRSHPKGSPRRGQPRRRISSPPPPPVFQPRVSFDTFDKPADFIEENSFTLIAKHKDYEYTKRSRTFLCGCDDNDYSDYALQWLIDELVDDGDEVVCLRVVEKDDNIASDRSVEKGRYRAEAEALMKSVQGKNHENKAINLILEFAMGKVNSVIDDMINLYEPAILVVGTKGRSLGGFQGLLPGSVSKYCLQHSPVPVIVVRPSSKRNKARNKRALDPNRHSYKDLLEKSGHLIDTDARSFTAEDTRGASEDEAAAVAAAIGYRPLGGSPLIQTQTIPVTLDRTIADQDLKSPGVIMKSPELQNLESPEISDSSSSDDEDEGGVPTATSGLGVNLDTEAGEEQTVPEIKGKDSGETGAGHNGAESTARERTETKAEEVLKAESTQHHHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH60</accession>
    <name>A0A9P4PH60_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_413554</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH60"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="307"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="48"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="725"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="132"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="747"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="829"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="886"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2443940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="911" mass="102421" checksum="0D88109D394B8437" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHJ6</accession>
    <name>A0A9P4PHJ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_494171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHJ6"/>
    <dbReference type="OrthoDB" id="4840035at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="1">
        <location>
            <begin position="148"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="608" mass="68341" checksum="C6355197C30C4FAE" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHK3</accession>
    <name>A0A9P4PHK3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_485630</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHK3"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2444165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="99" mass="11730" checksum="8746E28FD4DF546A" modified="2023-09-13" version="1">MSSRTTVLRLYRRSLKLALDWAVHRYLWRGQAMYIRSLFEANKTVTEPRRQRDLIKETENLLEKWKHPDPYRPPTAPGGSKYERNLPAPILDPPPKMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHR8</accession>
    <name>A0A9P4PHR8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_473693</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHR8"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="68"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2443403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="471" mass="51383" checksum="DBEC8FF2F6F13959" modified="2023-09-13" version="1">MALPITTIAESKELRGLNLIAAHSHIRGLGVEPDTLEPKSSSQGLVGQEKARKAAAVILQMAKDGKIAGRAVLIAGPPSTGKTAIAMGMSQSLGPDVPFTMLASSEIFSLEMSKTEALTQAFRKSIGVRITEESEVIEGEVVEIQIDRSVTGGNKQGKLTIKTTDMETIYDMGTKMIDAMTKEKVMAGDIISIDKASGKITKLGRSYTRSRDYDAMGIDTKFVQCPEGELQQRREVVHTVSLHEIDVINSRTQGFLALFSGDTGEIRSEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDELAPIVIMASNRGNTQIRGTDYRSPHGLPLDFLDRVVIVSTHPYSRDEMQQILSIRAQEEEVDVSPDALALLTKIGQETGLRYASNLITTSDLIRTKRQGSEVTIDDVQRSFALFYDPTRSVKYVAESEKRLIGDAGAVSLSVTNGAGAEAMDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHZ8</accession>
    <name>A0A9P4PHZ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfide,quinone oxidoreductase/flavo-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHZ8"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="37"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="445" mass="48477" checksum="648795A3771757E3" modified="2023-09-13" version="1">MATLLRASGACQKAASAAQARTFASVAPAAASSRSHKVVVVGGGTAGMTVSHQLLRTGKFTQDDIAIVDPAEWHHYQPGWTLVGGGLKNKEDLRQSLTELVDPKLKFYNEQVGAFTPEENLITLSNGDKVNYEQLVVAPGINVDTSTIKGLPEALADPKSFVSTIFKYDTCDKASRNIKDFKKGNAIFTHPAGAIKCAGAPQKIMWLASDHWQRAGLYNYNDPASSPINISFATGLPVMFGVPKYSATLEALRKERNVEGLFQHDLVEINGDTAIFARPDGADKVTKKFDLLHAVPKMGPYAFVKNSALADQAGYVDVDQATLQHKKYVNVWSAGDASSLPTSKTAAAITAQAPVLVSNLLRRMNGQEVEAGYDGYTSCPLLTEYGKVLLAEFKYGGVPKETFGRLFDQATPNRAFYYLKKDFFPWVYQNYMVKGRWGGPSGFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI26</accession>
    <name>A0A9P4PI26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_455280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI26"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="3"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="447" mass="48440" checksum="8AA46860741C292B" modified="2023-09-13" version="1">MATLTTPFGSFKGKYADGVVQYLGIPYATLKNQLSAPEMVFSYKSVVDATEYGPRAPAPDTSLFEQQFLIQSVIDDTPSPRMSGTECLNLNITVPSSIDPESVNKLPVMVFIHGGGFLMGSNSAPYFDPSRFVALSAELGTPVIVVSINYRLAVLGNLTSSELRAAGYPGNNALQDQKCALQWIRSHIEGFGGDANNVTAFGVSAGSVAVLTQLFSTEPLFKRAIAMSGTPMMLKPLPAAVAEVTYNSIMEALGLENASVEERIRRLITISPEELVEKTPMTARLAPFLDGDILPEAVTFDKLASRMVIPGMKWCGALMIGDCQHDVTTAILDAYGITPSISDDIALKHTINLATDILYATSALYYARAWPGKRYVYHFNEGNPWEGQFKGMATHMLDAACLFQNYNHETGEHGKDVAGTLANGFIAFTNGMEPWDSIAWDEFLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PII8</accession>
    <name>A0A9P4PII8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_454499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PII8"/>
    <dbReference type="OrthoDB" id="10259513at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012472">
        <property type="entry name" value="MCP1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07950">
        <property type="entry name" value="MCP1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="3">
        <location>
            <begin position="173"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="303" mass="33420" checksum="B43D60E910902C6A" modified="2023-09-13" version="1">MANNAPDLPPVADDDTGVMGLTQVDPSPVEETPLEYKEGYFPPAQAARATTLGLGNHGPAYYLTRIQKYSSYAFTVFAAFHITNTSLVPLLTRSVPEANRYLLLTRPYYQSALAEPLLVALPLAAHIASGIALRFYRRRQALKRYGAETHTDRKTIPWPSLSGTSALGYALVPLAGFHVWTTRILPPYMHGDNSMISLSYISHGFALHPLVSFGGFVALVGVGTWHFVWGWARWLGYAPSQASPTESRRHLTKKRRWYAINGVSLALTGLWLAGSLGIVGRGGKTGGWIGREFDELYNAMVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJG9</accession>
    <name>A0A9P4PJG9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_413791</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJG9"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="222"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="371"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="519"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="683"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="882"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="1067"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1084"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2444059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1210" mass="134952" checksum="83ED8882DD127355" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJQ8</accession>
    <name>A0A9P4PJQ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_455070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJQ8"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="279" mass="31960" checksum="9830FC0A85D97C01" modified="2023-09-13" version="1">MTTPKLVSTVTELAQVLDRLNLSTTVPPHLYIDIEGVNLSRNGSISVFTLFDRTQKYVYLIDVHSLGFAAFTTHSATCATFKDSGFEAIGADAARYITLKTILESPEIPKVFFDVRNDSDALFAHFGIRLQGVQDLQMMELATRCRRNRERVNGLSRCLEFGLVGILSPFQRSQVQSIKARGSALFAPEKGGSFEVFNQRPLDVTIENYCMQDVIFLPALWSLYNQKLWVPFWKFVVQHETKKRLEESQAPDYVPQGKHKTLGWTWGYLRQMEMKWNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJR1</accession>
    <name>A0A9P4PJR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJR1"/>
    <dbReference type="OrthoDB" id="3899716at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="177" mass="18861" checksum="55C1FF53245BE15B" modified="2023-09-13" version="1">MPASVASAPVNRTTNKAAASRTKKPAGAAAKKTQNAANGAANGAHQATSPYTIMASRIANRVAEMAENMTFVEREKPQSPQNAPAVQAPKQKKPPRKLDIRVPNNGASPTNITFSAPFLDNTLSKLLTLQNRMLKVSNDIAASDDVDEHTKQEQFAQSAELSRIIALICAEKARQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKZ4</accession>
    <name>A0A9P4PKZ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_412181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKZ4"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="338" mass="36539" checksum="6AC9394034166174" modified="2023-09-13" version="1">MSDTMRAVDIEGGKGPRSALHIANVPRPKLAASQALVHIKAFGLNRMDLLQREGMYPVPPGASKILGVEFSGIIEELGADGGGKEGFNKGDEVFGLAYGGAYAEYIAVSTHMLVRKPKELSWEQCAGIPETWITATQAMYLISKFAPGKTILWHAAASSVSIAGIQLSKADGAAAIYATARQDEKCEFAVKELGATAAFNTTTQNWAEEVLKATDGKGVDIIVDYIGAPYFGDNLNALARDGVCVSLAVMGGAKLPEGVDVSAFVRKRISFVGSSLRSRDEEYQGKLRDQLVEHALPRFKDGMFKIPIEKVFPWEQIQEAHQLMEENKTKGKIICTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL18</accession>
    <name>A0A9P4PL18_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL18"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="47275" checksum="049781CC0B90B490" modified="2023-09-13" version="1">MKTDYYLNLCLEQAAQSPLRYRHGCIIVRGGKVIGQGFNDHRAGFDGGALKTGVLPVRSLNPAAVAELKKKHKHKRDLKNPSSDATTFTPFEAMGGGGKLANTPLSMHSEMMAIHSALSASTTLVSTAVSSQKPYFKLSGDSKRKARLRRDAIKTYVETICKVALAQSTEQRFGRPGHAFHVPMEDSMEKHRGKDQKNRHHENHGHQKQQRRQCARKLSAQETLMAPGHSSLICKPAELSISDTTTITGALSHATGTNTAPMKFSKGRTGEKKRSTVDRKKHPRLNGADLYVARLGWQSSAKSGPSPCCEVLEHPHTATAKQPTGSLHEELLNPGPVSVSAANNAPIKIEPEPSVLASRPCYRCIAYMNSVGIKRVFWTTSSGEWECAKVRDLVDALDDLGSGDAAADAHTTLNSVFVTKHEVLMLRRTMGADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL25</accession>
    <name>A0A9P4PL25_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_431301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL25"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34862" checksum="8798C4662FFAF222" modified="2023-09-13" version="1">MDGNHHQLFSPAQLIAQACASLESGSSLLTQAATDLSYATALLNQSITPRSKQSGRKSSKIGGPKSQSQKGAKKPTISPYFPEPNNKITKKPTAGPTKSPFFPEPFSRDRPPPGLNFELQTPEFGLIQERICGSLFALIVQAILWNKTKGTAARPILWKVLCTYPTPELLASADPIAVQELIRILGLQERRAQCLVKLANVWVAAPPSAERRYGRRNYPTQGSNKEVKDRELLARNDKREGWEIGHLPGIGQYALDSYRIFGRDRLLGLQNAEGVEPEWKRVVPSDKELAPYVKFKWAQEGWDYDVASGARTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLI2</accession>
    <name>A0A9P4PLI2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLI2"/>
    <dbReference type="OrthoDB" id="3797550at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="130" mass="13351" checksum="F3B96598A71BBDA3" modified="2023-09-13" version="1">MEPHTTNHIPHADESTTARTAENIASSKTTSDAPLLPHAASSASDVASKLKSAVENVASTVKTAASSVLEWTEAKAEKLTAQKEDGTGPYGSVSTCAPSDLDPIGQGVLPALPVAKKEDVGRGEGEEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLN8</accession>
    <name>A0A9P4PLN8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MBOAT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_357687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLN8"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="594" mass="67233" checksum="8CA30CE366460ABA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLY1</accession>
    <name>A0A9P4PLY1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_430626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLY1"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF3">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="201" mass="21835" checksum="281BD2705F06CE3D" modified="2023-09-13" version="1">MESADTFTLLPLAMDPATKAITANPANAALQNELEALNALHRGLISAGTPTGTPPPPVPVNPTRSAQIGKLRESGNNEFRKGNHAQAVKLYGLAIDMALGRPHWEPSGLVREEVSGLLSNRAQANMAQQNWPEGAVDAEASVEMKKADNAKGWWRRGKCLLEMGRLEEAETWVRQGLEFGANEPDLVQLKHEIEKRKTGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMW0</accession>
    <name>A0A9P4PMW0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_431219</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMW0"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2445829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="371" mass="40790" checksum="BF8D9117F433505F" modified="2023-09-13" version="1">MPIRSEWKLAREGWTLDTTTRLLKATAFNPLITLPLILAAKYTSRGAQVASQNETLFRTLRSLVALGVLGSISGWLDDKVINNWKRDGWHWEKEVVVVTGGSDGIGKSIVFLLAEKNIKVAVLDVQPLTYEAPPSVHYFQCDLASKNAIEATAASVRSTLGDPTVLINNAGCARGKSILDSTENDIRLTFNVNTLSHYFLAQQFLPNMIQRNHGMVVTVASLAAYLSAPNMVDYAASKAAALAFHEGLAAELATQHKADKVRTVVMCQGYTRTALFEGFAGNSLYPETVAEEIVKAVLKGQSAHLILPENSWGIVPKVRSWPLWMQYGMRKGLKNLMKSWKGRQVAQPSEAQEEEKEKKGLGQSAVLVEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPF2</accession>
    <name>A0A9P4PPF2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_356909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPF2"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="296" mass="32570" checksum="D20D59CECBB58C0C" modified="2023-09-13" version="1">MAPALGKRKRITREELEQPSRASSPSSASQNSDGEDMQARFRRAFEAKFAPLDIEPVRTKSQKVEEPEEEPEEDSDWSGISASGDEDETSNGVQVFDYTAAHQPHTKGSKSEYRAFMSAKPPSLAATTTAKPKAAPKPTKEDDTVEAAHMKNDLELQKLLRESTLLSSNAPTYSTRTGSTRESNDARHKLTDLHVQSLGAKQSIFTQKSMPMSHRKGISAKTKMRDDRRRAEAKENGITLEKEQKVRKSAGKRDRGVGAPSVGKFKGGTLTLSKKDLRGLTSSAGDKDKGKKGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPV1</accession>
    <name>A0A9P4PPV1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_429993</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPV1"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2447063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="108" mass="12116" checksum="79B397F9950FC1DF" modified="2023-09-13" version="1">MGFEQGDAKKGANLFKTRCAQCHTLKEGEGNKIGPNLHGLFGRKSGQVEGFSYTDANKQKGVEWNDDTLFEYLENPKKYIPGTKMAFGGLKKPKDRNDLITFLQNETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ16</accession>
    <name>A0A9P4PQ16_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_471534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5089701at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2447168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="786" mass="87620" checksum="4838B0D4933C3372" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQS6</accession>
    <name>A0A9P4PQS6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_451770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQS6"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000925">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="269"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2449589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="475" mass="51719" checksum="A4A5296E4087CA91" modified="2023-09-13" version="1">MELGTILNARLTAHAGTGSPFGMQHAMQHQPQHFAAQPAYMNGHIKSENGSERGVSPHPSDSSRYSSQQPQQALPSYPPIPAQHMNGMRYPSPTPMQQAPMQMLNNNSYIPNPQENPYAQQQVPDQQTQHAGGRPANENGPPKAFACSTCGKGFARRSDLARHERIHSGIRPHVCEYPNCGKQFIQRSALTVHQRVHTGEKPHMCERCGKPFSDSSSLARHRRIHSGKRPYKCPYADCQKTFTRRTTLTRHQNHHTGTVEEAAAATAAALASRASAPSRSARSDAEEYSETASPLNTPSPNDRLTSMSPAGGMPAGVVPGMHRQQPEYAYMGNMNVPPHLRNEMPQPSPRASPALTSQSYTSTASGSRPAITSHPSGYGPPPILEPPASANHNQSGANSANGSPHMTAVGWQSPSHQALPSPGAGDNSYVYPEPQYANPPHNMYYQNNNIRRPNSTEPDHYSTNQGQQMWAPAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR72</accession>
    <name>A0A9P4PR72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_481959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR72"/>
    <dbReference type="OrthoDB" id="10540660at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="184" mass="20359" checksum="E46F2A802A6AA333" modified="2023-09-13" version="1">MPSLRTTLDWRYALFFFLIGGVIFTLGDFLQTYLSCGQYWFYEKQCATPRANLERRGVSHHGLDIPLAHDGTTLFTFPVQYNSDYAKEAGVVLVPVAQDLDANDDGVPDQPVVWEPTLPDFISGIEDKPTNSVTPAAGEMDAARPPKRTKRGRPSAAALEELAQVSATPTQKHECYEAEMMACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRF8</accession>
    <name>A0A9P4PRF8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_429252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRF8"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF2">
        <property type="entry name" value="HIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="44"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="196" mass="21706" checksum="9BE259254037C498" modified="2023-09-13" version="1">MNEPDLHYPADNCPFCTIAAAYPPSSSPLWTSKEEDLLGCVPSGDVDPEKTTPGSFVVLASRDVVAFLDILPMVGGHLLVATRGHRVKVADMGGGEGREMGFWLPVLSRVVSQVTGVKDWNIVQNNGARAAQVVPHVHFHIIPRPESRPEIKSKSWTMFGRGQRDELDDEEGVRLAGEMRRVLREEIVKMNERPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSC3</accession>
    <name>A0A9P4PSC3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_348630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSC3"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="387" mass="43481" checksum="638D983DD0B4112B" modified="2023-09-13" version="1">MAKTPYSGESWIWWIVVLAILSARLISRRLLFRSIKGLQVDDWVMGLSVTTGYTAFIVIFNKYLKAGSNLEPNGFDWSVLSAGDISRRVYGSKLMVVVEQLLIFVIWSCKGCLLVMYHRLTRTALHKENIAIKLLAGYVVLGFVVMEVLYFAAWCRPFAQYYAVPTASKQCDTLIDHRITKTVLNVSSDLVLLCISLQMLIRSSLPLKRKLVLCFIFSLGLFTIAAAILSLNYSIRSSYQRTWLSWYLREVSMTIIVANIPFTWTIFRELFEIDEFNASSPQPWSFYTAPQSTTKSNNARFPQATSPSLPTAHTHRDRLVVTGLGSQDTQSPTLVGSLSYRSEVSPPKILGFETSRRNKTTQVGSYDFAPAALPSAHDEDGISPVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSH1</accession>
    <name>A0A9P4PSH1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_405991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSH1"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="160"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="9">
        <location>
            <begin position="289"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2448139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="587" mass="64656" checksum="C024CB5BDBF4D7A1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTK9</accession>
    <name>A0A9P4PTK9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_350920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTK9"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="328" mass="36565" checksum="D894026FCEC4C2F9" modified="2023-09-13" version="1">MVLHNPNNWHWVNKDVSPWAKDFLTNEVLQISAEEDGVSVKVDSLMSMDGDVDVSQRKGKVITIFDVKVKLEYKGKNQEGEEASGTITVPEVAHDTEEDEYVFEIDIYSEEKSKQPVKDLVRSKIVPQLRKSFAKLGPALVNEHGKDIQHAPGENPSSKFAPAKTYSNSGINKSETKSVPSATQKSGGSLVNTTTINESTEFRTTAEELFKTFTEPDRIAAFTRSPPKNWTGAKSGGTFELFGGNVSGEFTELEKPTHIVQKWRLAQWPAGHYSTLSIWFDQNDVDAVTVMRVEWKGVPIGQEEPTKGNWGEYYVRSIKTTFGFGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV21</accession>
    <name>A0A9P4PV21_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_480892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV21"/>
    <dbReference type="OrthoDB" id="3793129at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="285" mass="32004" checksum="48FCC208F521DE52" modified="2023-09-13" version="1">MSSNNAVVAPAPVLKFPIQLKPSGKAVSGAKEQPKPSPQKDQAESKPAAQKQDLATIHEWAMSLNVNTRDLRELSREERLALLDGPTAPLIAGDKVIGAAPLRLIIAASSTARNEFITTNKIPSTTLMKFNCYYLKTSTFTHDIDLILAAESTDLDTYIRNIRNFWWAYLKTKPVAEIGYQKLKDLETRTVSGTENFAMTKMLVKRLAQLWYHYEIANIFDFDSWMETLPKMLKAMNEHIDQWDALRAQRKMVAEQKQEQAKKDAFAEQLLVARGGRAGGYGMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW40</accession>
    <name>A0A9P4PW40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Charged multivesicular body protein-like protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_7866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW40"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2451531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="216" mass="24462" checksum="06FF7BA2D950D268" modified="2023-09-13" version="1">MGNSNSSRKISAQDKAILDMKNQRDKLHQYQKRITVLTDREKEIAKECLGKGDTNRAKLALRRKKYQESLLAKTDAQLAQLEQLTSDVEFALIQKDVLYGLQQGTAVLKEIHKEMGGIENVEKLLGESEEARAYQEEISELLANKMSNQDEDEVEDELEQLEREVNGIQTGVPALPDPPVAQPELTPEQKAKAQRARRARDREQQASEESRQPILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWS4</accession>
    <name>A0A9P4PWS4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_376395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWS4"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000447">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2451906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="524" mass="57107" checksum="4160D5EF03E3DA82" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWS6</accession>
    <name>A0A9P4PWS6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_427002</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWS6"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="239"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="320"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="424"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2450678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="654" mass="71960" checksum="C7D586FCCA66A4A1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWS7</accession>
    <name>A0A9P4PWS7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_146230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWS7"/>
    <dbReference type="OrthoDB" id="5054768at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040471899" evidence="1">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="146" mass="16100" checksum="77FE8F62E520E131" modified="2023-09-13" version="1">MGCKAWLLPVTLLQGVLASDVDMDPLSNLRPDNITGLIYYLYRWAGSYYNGTTTIRLQPHNTFQQADCGRFAPGPIIVSYNASLLAVTQTNGHIVQEDHDAANPLAFSLKFWNAGLEILPSGNMDTGPVKDIQDISSVQYVLDVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWX9</accession>
    <name>A0A9P4PWX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_426403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWX9"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43054">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43054:SF1">
        <property type="entry name" value="SCYLLO-INOSITOL 2-DEHYDROGENASE (NADP(+)) IOLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="141"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="331" mass="36521" checksum="278505A0F594E9C3" modified="2023-09-13" version="1">MVLNFGIIGTNWITHSYVECAQATQKWNLAAVYSRKEESAKEFASKYEGQKIALYTDLNKFYADPNLNAIYIASPNILHYEQAKAALEAGKHVILEKPSCSTSEELDELFALSKSKGVFLIEAWRHIQEANFKILKQSISKIGRILGASITFCQFSSRYDAVLKGEVPNIFNLEMGGGALVDMGCYTVAAAVWLFGAPKDAHYHPVIVSTGADGGGTLTLQYEGFTVHLSSSKMHTSDAPSEIYGEKASLIVPTITDIEKVTLSDPRTKKREELGTKKENLNLKEEAAEQARIITDEDWKAAGELESHSRAVLKVLQKVRRDNGLLFPGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PY89</accession>
    <name>A0A9P4PY89_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_151452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PY89"/>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="708" mass="78592" checksum="BC90A18543782AF8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PY97</accession>
    <name>A0A9P4PY97_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_427289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PY97"/>
    <dbReference type="OrthoDB" id="2119662at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052031">
        <property type="entry name" value="Membrane_Transporter-Flippase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549:SF2">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN NORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2451061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="47774" checksum="9E6DFED4F6F2FBDC" modified="2023-09-13" version="1">MVVTTDSYTYIGVVAEVLNEGLPRAAYLVIGDHSSRTFRERLQLTHTLILFQSILGLIMSFGFLGGASTFAKGFVPIEVRDASLTYVRIAAFSALSSAIEYAVGTSTRALDRPDVPLIISSIKFAINIILDLVVISKFHVGGVTPTVNLQAGIQLACNLSSALAGLAYLVYATSLKKTSAARRDSSDISLTPSIAALKTLAKPGLVFLWESAIRNALYLWLVHGIVSMGSDYATAWGVFSTIRWGLVMVPVQAMEATTLTFVGHSWGQFRNSLSVATTKHQASWHQIWTITRWAAYSVSIALAFEVPLCLLMSFLGARPFARYLSGSDEVARIAAHMWRTIDWCYLCYAVSTQLAAVLMATRPKWYLYQSLVSNIVYVLPWAIVCQVTELNPGDAWTYHSVVFGGSLVFSLFDVMLFVAYWARTLARKKTRDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U660</accession>
    <name>A0A9P4U660_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_435641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U660"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="265" mass="28542" checksum="C33CE11A8F5E9EDE" modified="2023-09-13" version="1">MDPPQNFKDKVVTVAGASRGVGLATAKFVLLRGASVSISSSSAANIAKARAQILEEIPNCDDRLLDFACDITKLDQVEAWISETIKRFGRIDCCANVAGKEQRHIAPLTTLSLEHWREIIDVNMTGMFHLLREELKVVSNGGSIVNVGSVNSKYASFGQGAYIASKHGLMGLTKAAAFEGAPKGIRVNAINPGGIRTEMTAKPFVLPDGGQFNASGDTLPQLIRRMAEPEEIASSICYLLSDEGKFVTKAIWYIDGGFMESNFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6I7</accession>
    <name>A0A9P4U6I7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Taurine dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_466835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6I7"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="37"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="392" mass="43795" checksum="1E1443DF7836C580" modified="2023-09-13" version="1">MAPGILEENGSSQTPIDNTHASEPFKPTGVLEKFDYEDVTPIIGREFSTLNIVNDLINAENSDELLRELAITISRRGVVFFRSQDNLTNDLQKQLVDRLGKLTQKPSGSTLHIHPVLNNTSEFGVKDAEISTISSQARKQIFKHDRQADKRRYDAAQWHSDIQFEPVPADYTSLRLVQLPRDERGVPTGGDTLWASGYEIYDRFSAPYRKFLEGLTATFSGEGFTRAAAANPDKVRIHEGPRGSPSNVGKELSAVHPVIRTNPVTGWKSVFALGPFPKQINELHTDESEELLKKLLNVIPNSHDLQVRFKWKNDNDLAIWDNRSAFHSATFDYDSLGERFGNRAVGIGERPFLDVNSKSRSEALAEEAGAKVSLPTRKAEGEQKEQVLTGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6N5</accession>
    <name>A0A9P4U6N5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_490991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6N5"/>
    <dbReference type="OrthoDB" id="3939438at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2438323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="418" mass="47965" checksum="60F693B2D41BCEA8" modified="2023-09-13" version="1">MDQPRSLTTLFGYDEDEWIDRSCQLYPAGANASDWETNQVAGDDRCYSIIEDTVWPGLGGTRDFLHLLNDNSSSNMDNATLRQPGTVFGHLIATKNQDAMSDGVGKNLQTVEDISLTDGQRKSSFQFVSGSVVVKDNSDSKNKKRSTKPDTGIRCEHPGCSYLGTFNRKYDLQRHMTKHSNLQKGKCPLEFCERHFDRYDKLREHLRKAHADTEEAICPNSQCNMRVPFMLLDYHVNIHYSSSTTVVEKACGGRLSDLRSCPIASCEYNTKKLLIEELQEHIRQHTTKDRDKSSGAILAAGYDPANGNVICPVCKTRFCAMEDFYFHLQNEHIFKNGYYAQNIAETWHMIWHITRYVLWRTEPVSGEVARLFRVQPEAHISQLRPHHEYAQHRLAILRLWPDFHEHPLFDEFTKASVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6T2</accession>
    <name>A0A9P4U6T2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_458536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6T2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="282"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2438337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="602" mass="66938" checksum="BC77709CD096625E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U790</accession>
    <name>A0A9P4U790_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_85657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U790"/>
    <dbReference type="OrthoDB" id="3788508at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="17378" checksum="52424C5AA48EF599" modified="2023-09-13" version="1">MSMTDIARPACGCRHAMPIPCARELRRNTRSSWLARVAHHLPIPWIRPLRRKRRLTLESSPPCLVHFLTFATVDTSCGSVATLRSDAMSKDRILGAFAVALAGVACAAPAPQRFGIGIVPVPTVFPVTNATIPPKPTPTDTATTCEASYEVRYPELFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7D4</accession>
    <name>A0A9P4U7D4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_434764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7D4"/>
    <dbReference type="OrthoDB" id="152248at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040199827" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="157" mass="16551" checksum="3CF2731C0F273869" modified="2023-09-13" version="1">MAPAMLLFIIALLACTSLVAAAPHPVARATLPPNGAATVKAVKVDDPDVDSEGNGCRAGSIAAAFTKDNTALTLIFDDFQAAVGPTAGDLKKRAFCRVNVTLASPGWAFDVSTVDFRSYVNIPKGVDVSIVSRWKWINSKGVDMKGKVGQCEPCRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7G5</accession>
    <name>A0A9P4U7G5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_489911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7G5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="199" mass="21441" checksum="0AD33EEA684D59EA" modified="2023-09-13" version="1">MADKTRRNPMDPNENDRIASNQDQPSAAVGAPPVLSHYSDSAQGASAHATGRSNAPSGVGTRAPAVGNNPDGGNAPHSTNRYVPPHAGNARQMGTAPSSHLPPSTLPISNTPTPNARPASTLFHSQEQEKEKPSRLPERPPAEKHEQVRLGFKQPVHLQRLEKASQKHPRTMEYDEEDRILLEGLARREREDGDGGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7M5</accession>
    <name>A0A9P4U7M5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_476961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7M5"/>
    <dbReference type="OrthoDB" id="3795421at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="37090" checksum="33C5A9CD73A9584D" modified="2023-09-13" version="1">MEEGTADNGQSALLSTKEEHMSQLATSRIRDSTTTELYTDIKSPPRLDNLPAEIIRRIISHLREDTDPIYDEDTGTTETTVLDRFRHDSENYRSVALASRVFTPWAQELLVDSPVLFHPQRFSAIREPSPFSFLARTLLERPDLRRKVRQLTVFLPTHNHAISIARRGLWGDGPDVDSANNVLEPGRIYQARRRLHQNSQNPEGASCQLEKKAEDTIPVPSYRHYPDSGNQQSLIIRGPAPVSLSGLEFFPAIRKLHLRLEFHPNRRAGLHPLVISSTSFQNISKLRLACAQVWSFRYYKPNRLLRPASGRVWELKASRSLGRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7N2</accession>
    <name>A0A9P4U7N2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein TmpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_448164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7N2"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="91024" checksum="F5022F360EB2C802" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7T5</accession>
    <name>A0A9P4U7T5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_338594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7T5"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040137704" description="DUF7492 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="3">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="341" mass="36536" checksum="B2F8C8EA06A572E3" modified="2023-09-13" version="1" fragment="single">MRYTLIAAAAVLACAPQAAAHSWIQQLVNVNDDGSYVGNWGYPRGFCAKGETGCDPGVMNNFLIPAQGIYISEKDSLCKDSQQKPVQREPEKYPRLKAAPGMHIALRYSENGHVSLNGTKNEDTNKFKRSKGGTIFIYGTTNPKEDEKLVNVLQWTKDGNGGDGQGVLLATNDFDDGRCYEANGSPISTQRASANPSYAKGETGQGTGEFGLPCESNVLLPKNATAGKPYTLYWVWQWNTPPGLDQNRPKGQDQYYSSCMDVDVVDTQASEAKGEAKYFSPQQDDGSAAVKSFADRTALYTNAIEGEIGPVFSKVQPTTGAPPASGPASTALTPAPTSVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7X0</accession>
    <name>A0A9P4U7X0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_435368</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7X0"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="157"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="443" mass="50216" checksum="EB8F484F7D1A30B4" modified="2023-09-13" version="1">MDIAALVNPVSESLPRRSPSGSHNIILASSPALENATLPTTPRQSHTSVMSRKRKRHDPKPIWAVREDEIFDGKTLQQDINERQRQQTPKSHPQVQAQAQAQPRPQPSPSQPPPVASRNGHAQIQTPSQPSSAPQPTTSAALAGFERPISHDPRVYDEIQRKVCDFLFTNIVVNDRIRVLLQEAPDTTVEVEARWGHIVWREQNERLTGVHSTECVLHSTVSQRTKFDSVMNLQQHQQMNKYLNKQVFQAKPGNPTNRPEIGYKHTRLVDQQFELGDEALSRLSPAAQSIIRASGKQERIRVSRDQKTGEVVAAIIKHKVNNLEISSPQTEWDYRIGINIEIVFPGSLDGLTEVVEKGKGVEAMKRYKDRMSYSYKDAYQIDLTQVTQDGQRIHELELELESSVLLEHGDRVRNQQPNEYESLINGMINNLRVLSREVTPPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8A1</accession>
    <name>A0A9P4U8A1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_489357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8A1"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="197" mass="22056" checksum="C894713D951CE42B" modified="2023-09-13" version="1">METPTTDANNRSPEGSGLPPIMDAAYCFESAFSALLCSTSSSHYERIEEAQALFRVWAGSLGVSAEFHASLDYRVRDSETARLLCLSQLEALQDALSRLSEIQSAGGFHSHATIASKLPRSSGLRIQIPKDVRSVQIQNLIDRLYRLAKEIRRPSSLSHASRAEHYAPLDEFGNNVIKEFERFITKLINIRLSRNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8K1</accession>
    <name>A0A9P4U8K1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_433896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8K1"/>
    <dbReference type="OrthoDB" id="3692903at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37382" checksum="13B1994CC2D327CB" modified="2023-09-13" version="1">MATIPTALDNSVNSFEPLFAQPPAMSGPPPSVFAKLPLELRQLVYHYVLVEDSDEKVIKVALNDTQLISDSLKNAAGAILVNKSMSNEVLNYAFSMFGFSLSDLEPSSYSILQKFCDRIGKKNVELIKEITIPHLLAHDVDSFQWNNFDAEIDRELYWAYDIYIYNRIFELQDKRLLSRLPSLKTVKVGLNFACASNVLVRLYDAKVPKGIFESLFSLPGPGFRYEVFPGLLWLLAEFRTRDIDFGIYWTDVWQTVHISKHGDSFPMTEEQIEFQKCSVVDVLNLLHNFVQDWKTCPVSNLGTLPDDLFAYGISDDYLDGTRPHLCKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U996</accession>
    <name>A0A9P4U996_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_433499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U996"/>
    <dbReference type="OrthoDB" id="5318346at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="54"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="247" mass="27316" checksum="2164A6CC2A0C79AF" modified="2023-09-13" version="1">MSVVVAGPNTALPSRPRRKPQAKPSRDIHRLLTQLADLQSSYTPSEFAKNIDKQLLYLTKSATTPFTRIVSLGLGSLSSTERGQTRRLKQLALLLAIQDALQQQTNAPIQVYAQDPTFTKQDEALLNSLSIRILRTASGSSLGEAADVIDASTLIYSPFLTLEAYEQLLVESRQPVQYVIGDDFNALLEKWPKYSAERAQVQKVTKAALGRYRRKAISGAGFWEESDGAFPMAVYAAQNKVAERARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9H7</accession>
    <name>A0A9P4U9H7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_414948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1613"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="domain" description="Sacsin/Nov" evidence="3">
        <location>
            <begin position="29"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1433"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2443449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1728" mass="193726" checksum="A161A555EA1D52A6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9T5</accession>
    <name>A0A9P4U9T5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_365159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9T5"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="410" mass="46151" checksum="4FE2DA1287003951" modified="2023-09-13" version="1">MLQKLRGNSHLHWPDSELTKVTSNSRFHGWRVGVLFGVVSSATILCFNMAVLAFVASTKHGFEGGFAEPFNLEAHKLSRLSTLIHVLINALSTILLAASNFTMQVISSPTRDDLDKAYKSGEWFDVGVLSIRNLKQIPRRRLAICIVLGLSPIPLHLFYNSAAIYIATTNQYNVHIINQASWNWRNLGFDTAYEDLSRGEWRDQYDTALVHHGDLYIGFNETAKLINGELIVDTNWNPNTAWELGGDRTLIHFLASSNVNSTEWLNFTSKSDTITPAFPDYARVAQVFAHRAPRRDKIVFSLYLLVIVIACNTVKLITLVFVLLMEKSDFAVTLGDCAASFLHSPDPSTTRMCVYSRDSVIATVRSRAKGHNSRLPVEKVATEDPERWRKQRHPYATPVSRSSSIGEYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9Y3</accession>
    <name>A0A9P4U9Y3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_76895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9Y3"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF37">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="160"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="522" mass="58929" checksum="86EE8045564FE28C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA07</accession>
    <name>A0A9P4UA07_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA07"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="137" mass="14579" checksum="AC282305B760A5B0" modified="2023-09-13" version="1">MPSMSTPTVSTGSPLSTTADLVGRFPEPSRANVTLDAQFLYPIPPVRGMTWLPSFLLTNNTLPALFAVTLTNMLYPQTCEESLHYDSECGGTGGSGAGGGGIEKALCLRYMDGVSSSFLQYSIVQCVFKICCNQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAC3</accession>
    <name>A0A9P4UAC3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="7">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_433431</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="7"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAC3"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="9">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="6">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="5">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2443090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="182" mass="20464" checksum="AC2A4C335B3C6248" modified="2023-09-13" version="1">MSPLTSDVIKFGAFVVTNQVFHLTPLSYALVNLKPLLPGHVLVSPRRPVPRIHDLSAAEVQDLFLTVQRVSRTIERVFDASALNIAIQDGQDAGQSVPHVHAHIIPRKKQDLPRPDAVYEMMESEDGHLARHLTKRDEADEKRGTFPAVDADEDRKPRSDEDMNKEAEWLAEEMAKDTDKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAS1</accession>
    <name>A0A9P4UAS1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_283875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAS1"/>
    <dbReference type="OrthoDB" id="3767798at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46534" checksum="9D9589E7446D187C" modified="2023-09-13" version="1">MIRIPSPGEYVLLQRTGRPDWPAMICTDDMAPINLQRPNGYLTLVLLIDKDLSFYYAASGELQEFVPIGGNSDKELQAAHNRVLESMDCSGSSLDYWRLKTEHQRKFTAPPLTAPTPTPSPNNDYISDQGSDVDEIEIAKRLSLHEWNKSKKRIRVSPSPPPPPPRRFKGAEGATNLRNYFRPIERGNPSISTESEPSRYKPAELDYIDGELSASCEMVKVHVGEQDDEFLIPKLEVEKLPFLSDAKIGCISTMEDGTLRLDLQCLKDFDPNDFRFVAEFLSTGQFGHSIVDEETREAVLQECVDAWPIADRIVLEDMLDHIVTKVQQAQLQLWEEAWVLALLVYETPGTPLGAYKLMKEFLVEMLAANFLEKVYDYGAVVIDRLRDLPELQRDVYKRLLATAEQQVNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB00</accession>
    <name>A0A9P4UB00_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_434070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB00"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="82"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2442597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="220" mass="25120" checksum="56221DD4695D1895" modified="2023-09-13" version="1">MFILTTIEDLIQIAPQDFSKESAQAIKDAINIKYANKVIHKVGLCITMWDMLKASEGLIGHGTGLVNVNVEFRVVVFRPFRGEILHGRIKSANEQGMVIDLDFTYEVFVPQANLFEPSHYDPGENAWVWSPPDGEEFFFDKGETVLLRVEREEWFDQKPSIVQKDENGNVVERRGVPWRIIASMNQSGLGPCMWWEGQEGEEEEGEQQLLENGDVEMDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBH7</accession>
    <name>A0A9P4UBH7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_494344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBH7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23800" checksum="1CE73B91F5595009" modified="2023-09-13" version="1">MEQHGVLPGRPQSQSSLEYGHAAQIRQIQSLPEPNNLESNGFLIQQYCDICKTTYTTPSHTCSGLSLVNEPDCPTHEGTGNSQVCMNPEGQNQLSTDLPLGWYYGWCNQARRRYFYGYHMGWRAKSQWERPISSGEALFGPSLPDCSQWVPRDPISEPPGYVALPPSEAERSVSPTLQSALSSLELSSTTEAVNPPLKIDRELCFFDSSGIGQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBK4</accession>
    <name>A0A9P4UBK4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_432671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBK4"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000361">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF26">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="93"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2443408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="540" mass="60804" checksum="7B265F6CBD5A99D6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCL3</accession>
    <name>A0A9P4UCL3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_494808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCL3"/>
    <dbReference type="OrthoDB" id="5041285at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040446704" evidence="1">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="255" mass="27010" checksum="71BB13032F66EB31" modified="2023-09-13" version="1">MASRTLQWISSALLLAHLGASSPTSKHKDDKPAAFFLAGDSTTAVQSTGGGGWGNGFLATLQSPAYGANKGHNGATTVSFVKGGDWATVLNLVKNATDAYNVYVTIQFGHNDQKPGNNVPIPQFKTNLATLTSDVQELGATPLLFTSLTRRKFDGTQLIQDLGDVVNATRKVAAESNVKLIDLNAASRKYVQAIGSADADKYNLVAGDRTHLNAHGSEVFGRIVADLLLESDESLGPWIGRNATLSHLIEEGVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCV2</accession>
    <name>A0A9P4UCV2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_431545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCV2"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040189055" description="Glucosidase 2 subunit beta" evidence="7">
        <location>
            <begin position="23"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="437"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="172"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2444743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="565" mass="62860" checksum="E04FADFDE02BBACF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDC6</accession>
    <name>A0A9P4UDC6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_520721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2446030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDC6"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="336" mass="37465" checksum="3F75083AE38986C6" modified="2023-09-13" version="1">MGYVADQTSLLVTNVTLIVAAELSVALRFWVRRRMRTPLAADDWCALAAGIVFFVQDVVMCWAISRNYVGLDPRKMDMEHLETSLKLVFIGIFLMSIILTLCRFSVLFLYNRLFGVYTTFRKILVVCGVASLMWPVTIWFGTTFRCSPVKGSWKLHIGAKCVFDIEHLFIGTEPINAVLDVLLVILPINKIKILQLPLRERIGLAVVFLLGGFVGFTSILRIIFTYNPSKLGAIVDSVFWLQLQLGTAIVCCCLPTLRSLLPSKQLFVPLGASIQGLLGSRKTNLDSRNNPSGSKTLGSRSVNVDRQRRINPPYFDTTGSTKSDDEIALTDVDSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDJ3</accession>
    <name>A0A9P4UDJ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Complex I intermediate-associated protein-like protein 84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_359147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDJ3"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF39">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="806" mass="91049" checksum="7BA7DAC14A11A359" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDY8</accession>
    <name>A0A9P4UDY8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_462846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDY8"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="370" mass="40732" checksum="CE5221E345E18CC2" modified="2023-09-13" version="1">MDKTDDGDNGPVILGVTWFLCAFSGVFLALRLYAKLSRHSRLWWDDYIIALAWVLLLVESAITQAGRGLGLGKHIWNVELEDAFVLTRNIYIGATVSCFAATLSKISFGITLLRLTQGPTKAFVWFCIIGLFIVMLPSAFLSWLSCRPTAKLYIPYLEGNCWPAQVTRDYGYFNAAFCTLVDFALALLPWKLLWGLQLQVKEKIGVGIAMSMGLLAGVCAIIKGVHLQDVTNVDFFYTGKDVTIWTVVEIATAIIGACIPVLRVFFKNTITSLYDRYHRTDGRSTATATTNFASHGSSSVPLEIVQSQKSMRTSISSVPGTEELGMVITDDSGRGHGGILQTNTVTVMHAPNPQGRIAEWRGAEVLSNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEC1</accession>
    <name>A0A9P4UEC1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KANL3/Tex30 alpha/beta hydrolase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_519846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEC1"/>
    <dbReference type="OrthoDB" id="6415022at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046879">
        <property type="entry name" value="KANL3/Tex30_Abhydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="TESTIS DEVELOPMENT PROTEIN PRTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136:SF11">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20408">
        <property type="entry name" value="Abhydrolase_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANL3/Tex30 alpha/beta hydrolase-like" evidence="2">
        <location>
            <begin position="161"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="312" mass="33129" checksum="7233E1736E9593B4" modified="2023-09-13" version="1">MADSKRKADDTNDAPEPKRRVTRSVSKAPAPVPAKQAPKPKSKAPAAKASKPSKRAAKAAPPNVEKTSNKTEESAVDSPPANDTPRAVLTIQHAAVKKPITCHRYPDSPEPNLPTPGLLFTHGAGGTLSTPAVVNFCTGYSTVHPMLAFQGSMNLAARIKGFHACISHLGLEKQRLTLGGRSMGARAAVVAGTEVLADDALRELWLVLVSYPLKGPKDVRDQILLHLPAAARVLFVIGDKDAMCPLDLLEETRGKMAAKSRLVVVRGADHGMRVRPVAEERRLGEEAGRLAAMWAGGEADDGDVYIGGEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF47</accession>
    <name>A0A9P4UF47_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF47"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="129" mass="13894" checksum="310E53CC37C45813" modified="2023-09-13" version="1">MRAHDSRVSATFNHSPLYATRAHPRPIPLSFPSPLQLNHPQHGGLSKVTAHNTVAQHSRKILESSAIVVCPPDSLPLSARQLSYTKTPSRSKFPRQSIATATPLARSSTNSEAKEDSEISSIVAPLPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF57</accession>
    <name>A0A9P4UF57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1348-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_409125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF57"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="152" mass="18227" checksum="A27321DE67CA6D4B" modified="2023-09-13" version="1">MSLNPPFTKESAKAKVKKAQDLWNTQDPKKISGAYTPASIWRNRDMFFTGTAAIEEFLTKKWEREKNYRLRKELFAFTDNKIAVQFWYEYQDAHDGMKWKRCYGLEDWVRYAKEYRAVLRQMSGNDAEIRNSERWFKGNVDVNTVLIGEKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFJ9</accession>
    <name>A0A9P4UFJ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_508813</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFJ9"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="619"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="630"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2448611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="666" mass="75210" checksum="D3E5A9B67EE90114" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFK4</accession>
    <name>A0A9P4UFK4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_216725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFK4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="181" mass="20096" checksum="C2CDC3F4CD12B9B3" modified="2023-09-13" version="1">MIHTTSLQGDDISSRLSRRMDSVSLEAKVLTKHHTAMFLDGTDEAKAEPGTKSSATGPRFPSFTEWKKDNTARISAVLEEHINGIAFTGAKSDVHDDGRAAKRKAKRQMPISSVINVTSSNSTWFTLDELDDKGTPELTAKRQRIWQNEAIQSEFSDTMDPMTDEIDAPVDAWTDKHMDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFP8</accession>
    <name>A0A9P4UFP8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NMDA receptor-regulated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_470740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFP8"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1010:FF:000002">
        <property type="entry name" value="N-terminal acetyltransferase catalytic subunit (NAT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="583"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="740" mass="84425" checksum="E0530E6EBABB0FEF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGU4</accession>
    <name>A0A9P4UGU4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="1">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_221465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="1"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGU4"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040464998" description="AA9 family lytic polysaccharide monooxygenase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="4">
        <location>
            <begin position="39"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="406" mass="40780" checksum="E0F89AA4FCB7448F" modified="2023-09-13" version="1">MFFQTSALIALAASASAHMILNSPIPFAFENEATRQAPLEPADFPCKQPAGTYSVTEMNTVAAGGSLDVQLMGGATHGGGSCQFSITTDTKPTKDSQWKVLHSQIHGCQGGPLDNNMSNNASDTNNPKIPVTIPEGLPAGQYTFAWTWLNKLGNREFYMNCAPLTVTSGSSKRDTASADVSSILGQLPDMFVANLPYTECAVAAGQDFVYPNPGDSVATGEGATPGTAISGTGCAAVTILGAGAGKLGSPAEATAAPTNGGGIFAPGASSAAGTAPASSAPAVTQAPVTSQPAASYQASQPAATSVASQPAAAQPSSPSAPDSGSETSSGSNNASSGAGAPCDSDGAVVCIGTDSFGLCNFGYAVAQKLADGMSCSNGQLSRRSIRFPRGTLHNRHAALHKRVSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGZ2</accession>
    <name>A0A9P4UGZ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_470425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGZ2"/>
    <dbReference type="OrthoDB" id="3788568at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="278" mass="31454" checksum="531640530E4F6F1B" modified="2023-09-13" version="1">MPDPDAVPPFLASVRNFRKQSSSRLLSLPAELRVRIYRCIDLSPLSAGFLSWTGVYFASRQLHCEIRDQVQSDAELEKIKTLILKRTCPDSLVIENVAAASGASWLNLGFLQNVIIHMRLDKIDQHLRYNRCNLLSQPYSLFLRHLKIVFTGHPADCHTFPWGDMKSTAETLVAPYVARRQINCTSVTFTLQALEDGTRTVSTLANKFEKLGVAYRLTIVQNKRGRQVERSYYSATRFKKEADPPTSSRGSNHDDHLRGPSIVRGFRPADSSVLSSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHP3</accession>
    <name>A0A9P4UHP3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_139835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="6"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHP3"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF8">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040431837" description="glucan 1,3-beta-glucosidase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="80"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="414" mass="45747" checksum="2D4BDF6AD39D5C78" modified="2023-09-13" version="1">MLLTRVLAAGLACGFAAAAPATTKRGVAFAWGSEKVKGVNIGGWLVLEPWITPSLFDNLGRSDVVDEFTLGEKLGQDAALKVLKKHWDSWCTFKDFQKIKDSGFNLVRIPVGYWAYDTLGSPYVKGAAPYIDAAIDWARGLGLKVLIDLHGAPGSQNGFDNSGQRISPPTWTEGNTVQQTLDIFSTITKKYAQTKYQDVVVGIELLNEPLIPSLEEPIVRQFYRDGFGRLRETSDTPIVLHDGFLPTANWNGFLTPSDNNAQNVVMDHHEYQVFTDALVALSPEAHVSQVCSSSSSYAGSDKWSFVGEWTGAMTDCAKYLNGLGVGARYDGTYPGSTKVGDCTWQNDISKWSQQYKDQTRKYIEAQMSAFETRAGGWVWWNFKTEGAAEWDAFKLVDAGVMPQPLGQRKFEVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHW6</accession>
    <name>A0A9P4UHW6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_439262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHW6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="178" mass="19573" checksum="91CEFD46234DBECE" modified="2023-09-13" version="1">MSYWVRLEEALWPSRFLRSLSGSKANQRLRSERHGKLPSGRPSVADMAYIGQVEALKSSRMGVVVSRIRVSSRAAFAHLLGIRVSSDRMRGSGQVRVVLRHLKEALQRGSSSERRLLLAPASSVVGLLGAKPRILRRWLVSQVSNRLSIGSSTSIALGGPRRQAVDQSSDESQCATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHY7</accession>
    <name>A0A9P4UHY7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pantothenate transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_348479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHY7"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="28"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2450710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="479" mass="54212" checksum="60B9465DFF1BAA4E" modified="2023-09-13" version="1">MASFIQYLRGEPRAPGERKLIFKLDFFILTFCSLMYFLNYLDRTNLNNAYVSGMKEELGFHGNQLNQINTVFTVGYTIGQLPCNVALYYMKPRIFFPSCMVIWAGLTMATAGAQHPRDIMAIRFFQAIFEASTFVGTHYILGSWYTKRELGKRSGIFTASGLAGTMIGGFVQTGIHSSMDGLSGLSGWRWLFVIDGIITIPVAIYGFFLFPDTPRTTKAPYLTADDKALAISRVPETPERTPISWGFLKHCFSTWFWYFFVVLWVIAGETESFSSNALLSLYMKAHPTKKYTVSQLNNYPTGVPAVGIVSTLFWATLTDFWGGRRYFVGYWIGITGVVTSALILAYPESTSINFAMYYWAGSVYACQATFFAWANDVLRYEEDSLRAVVIASMNMGNNAINAWWSIIFYGANFAPYFTRGMYAMIATSIALAIWTGLLVWMQKRTDRRREHEDVYAREEKDPVSAHDGPNEDNHVKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIK5</accession>
    <name>A0A9P4UIK5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">P171DRAFT_516284</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIK5"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="22">
        <location>
            <begin position="978"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="426"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="937"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF2450397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1159" mass="127998" checksum="5234DDCB3B9B3EC0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P349</accession>
    <name>A0A9P4P349_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peflin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_459211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P349"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="286"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2437440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="335" mass="37730" checksum="A363992AEB166A79" modified="2023-09-13" version="1">MAYNSKFNPDRLPAHAEPEQKAAALLGSGRDSARPPRTSSARPDYNDKPLPPSRADDRYGRGHSNSYGSYDSRPPPGAYGAPDPRYDDRSRYDTQPGARRDTAPPPRDPRYDGYGSPPPQNYGHGPAPAGFHHGRPPVQARPPPTPAPPRDGNDRVALDRLFKQVDRNNNRSLTEAELKTALVNGDWTPFDPHTVRMMIRMFDTDRSGSVNFEEFCGLWGFLSAWRNLFDRFDADHSGSISYQEFTDALIAFGYRLSPQFVQLLYATYDRRGDNNMSFDLFVQACISLKRMTDVFKKYDDDRDGYITLSFEEFLTGAQTLFLFNSISAATDTGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P3G4</accession>
    <name>A0A9P4P3G4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_477961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P3G4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="277" mass="31292" checksum="24548ABD919331CD" modified="2023-09-13" version="1">MSPSTPNLVSSPSGEVVRKVKKKTDGFVNHTSPPQTSSMGFEVTENTVLSAETVKMATPNTIINSDVLKIGEDEDADNDYYGDEDIFQVTTMAYVLPIVRKETTRETRRRDDEREHVYPREAEGLRRRIQFQHRSEHGQSPDRGCNYEDAGRLKNSAGPEDIRQDIESCCTIKRCVNPAMVSRLNVTKSMRDVHPIESAIDKTESRLSDISGKGFDTRVSEKYDCPNDILSKYLGNTKIGEVSRLLACHAVVQRYGNSGLVRDRAHGRQRRWDELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4A4</accession>
    <name>A0A9P4P4A4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1212-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_458773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4A4"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="768"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="832"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="371"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="867" mass="95512" checksum="29BDA1E0E09D2575" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P536</accession>
    <name>A0A9P4P536_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_449746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P536"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2437520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="366" mass="39769" checksum="396DCCEAEB7E1860" modified="2023-09-13" version="1">MSSPADHRPLDKPPKTPPVPVPSASVLVISPTNQVLLLHRVRTASAFSSAHVFPGGAISPEHDGPTPSITDTNPNQPAYRLAAIRETFEESGILLANKGGKLFTDISDADREEGRRAVHAGTILFPDLLSKWGCEPDVEGLIPFTRWITPPNVKKRFSTQMYLYFLPLGSTSPATSKSQPSGEAARLDDVEAADMVIPHPTHDGGIEHTAARFLPPNKWIDLANQNRIILFPPQYFLAWHLAPLLAPTVTSPASPVPSTAELQAERERLLEWLGGDGGAFGKAIVSPVVLGRGDYGEDRQDGIGGVDRDTAVLRLDYAGPELDKAGVRGEMREWVVTTKFKKEGPRDVRVVERGRILGRDGKASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5F9</accession>
    <name>A0A9P4P5F9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 12">Cysteine dioxygenase</fullName>
            <ecNumber evidence="3 12">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_400419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="3 12"/>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5F9"/>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000189">
        <property type="entry name" value="Cysteine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="10">
        <location>
            <begin position="103"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2437218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="211" mass="24049" checksum="035E064D6C91D2BC" modified="2023-09-13" version="1">MDAQEITHGRQRNTFEELVERLSAELGPYSGISSEDVDPKKLEQLMAEYVADEAHWSKYFFPSQHHAYTRNLVDKGNGKSNLLILVWSPNKSSPIHDHANAHCIMKVLKGSLVETRYAWPTVDLNQKEDHPLKTISLKMYEENEVTYMSDKLGLHRISNPSPTEYAVSLHLYTPPNAAVYGCNVFDEQTGHAKHMAKSTVYSEYGMKQPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P685</accession>
    <name>A0A9P4P685_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein uup-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_167371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P685"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF135">
        <property type="entry name" value="ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="44"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="476"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="682"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2438077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="740" mass="82216" checksum="7A89293356C3A3EA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6N8</accession>
    <name>A0A9P4P6N8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SPT2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_437845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6N8"/>
    <dbReference type="OrthoDB" id="5430658at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="336"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2437471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="39222" checksum="432AC75030C456CB" modified="2023-09-13" version="1">MNPLADILSSIDPSKARIFSATPPVQRLGTGSPKPATGRPPQRPAQPANGTPEASALKRKASNPGDVGLNKIPRKDAPAPLAATNGARSGSAPAGARSTSTTPTTSMPYRGTAGLGASKAANAQVKKPLPAGAGQTASAKTASSASRPTAPKPASAAPGASAAPVKKVGGYLAMLQKAKQKDATKPAAPPVKPEPVKIMSKKEREAARVAPKPGAKGKKPVAGAPGRAADPKAVAAVTPQEKRKPADLGYQGTARPAKKPVESGYKGTARSGAAAASSAPRPGASAAAIKKKPKPAQDRYAGYANWSDLDEMDDEEDDYASDGSSDMEGGIWDVEREEAEALKAAKREDAEALAEENALKREKEERRKKLAAMNKAAAAKKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7J7</accession>
    <name>A0A9P4P7J7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_491826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7J7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="129" mass="14828" checksum="D10F0BAC8D2AC9C7" modified="2023-09-13" version="1">MYLRPVPEAHIMLEIRMQQETQEVESQEAEAQNKHSKANIAKLPERLYNNERMNRTPLVRGSENMPQVPLMIGTKEAETKAQQLEALQQELDAKSQKAKTKIETISEEIAECERRGGKSVLRVKARYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7Q8</accession>
    <name>A0A9P4P7Q8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_489740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7Q8"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="318" mass="34803" checksum="D35B3DB5D844BDD5" modified="2023-09-13" version="1">MAQRKKSLLIGINYVGSKHELKGCHSDVDNVAEFLSYRGYNNSHRDRVILSDNSMVAPDSPYYPSGHNILAAMDWLVSEPGCTLFMHYSGHGGQVEDVDSNRSTGLDDSLVPVDFEYNGQLSSTLLHQHLVTRMAPGCTLFVLMDCCHSGSAIELPFVYRTDADGQISLIDNLKKGAQLVGEAQDIISGGFSFNKMGEARELFAGATSFFHGLKHMGEQEDEGLQNGEFVGQYGSENKMVTMFSGCRDDQTSADANIAGRSTGAMTWAFLQIMKSGGTPTYTQTLQMTRQLLDQSNYTQVPQLSSGLDIDLDNLPLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7Q9</accession>
    <name>A0A9P4P7Q9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_156513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7Q9"/>
    <dbReference type="OrthoDB" id="5429993at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="552" mass="60062" checksum="8A8391C625CC2743" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8E7</accession>
    <name>A0A9P4P8E7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldedh-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_489054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8E7"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="152" mass="16702" checksum="9E2BD851205ADE97" modified="2023-09-13" version="1">MSDLFVELTAPNGHKYKQPRGLFINNEFVKSQSGATVTSINPSDENEITSVYAAGPEDVDAAVAAARKAFKDPSWRDMDTNARADLLYNFAQLIEKHRETLATIETWDNGKPYQVSLNDDLGESGIGRELGEAGLEAYTNKKAIHVNLGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8H7</accession>
    <name>A0A9P4P8H7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_100240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8H7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="96" mass="10170" checksum="8687DF80F6A96544" modified="2023-09-13" version="1">MPCRRRLHDFSTSDVPGCAPRRRAVDGAGGGPESWGRPGDGARGVERFKWRNHAGTGCGPRSGRCGVHGSGRAAGNPSKIGAWARVLRCIYEVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8T7</accession>
    <name>A0A9P4P8T7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YVTN repeat-like/Quino protein amine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_123668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8T7"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="590" mass="65760" checksum="0565A25257DAF9E0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9E9</accession>
    <name>A0A9P4P9E9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Siderophore esteras-like protein IroE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_434591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9E9"/>
    <dbReference type="OrthoDB" id="446683at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052558">
        <property type="entry name" value="Siderophore_Hydrolase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40841">
        <property type="entry name" value="SIDEROPHORE TRIACETYLFUSARININE C ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40841:SF2">
        <property type="entry name" value="SIDEROPHORE-DEGRADING ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="312" mass="34950" checksum="4DC25D9C416801F1" modified="2023-09-13" version="1">MSALGNWTFTPLVTSFPSTVLPNLGFWNASNGTWEYQIEVAWPLNWTSREDTAIVETLYVLDGNAQGNIAAQAVRNRRPVEFAMPDTIVVSLGYPDLIPDSPYSEGRYHDYQPPVCATCPLPELPGVPSNANNFLAWIDEILKPWVRNELFPNTEFSRDALHGHSMAGLFATYALIARPDLFDTFLIASPALYWNNNYIFSQLGSLKKPAGSNGTKPAVALSYGGREQNPVKRRVETEEEFQVRKSFLTFSNMTDNVNALYNEIKNSTQLRDVELHEYPYSDHAAVGIVSIADGLDYFLDWAPRIAFQNLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9K5</accession>
    <name>A0A9P4P9K5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9K5"/>
    <dbReference type="OrthoDB" id="10551194at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="189" mass="20618" checksum="E5CBEB26EFF15794" modified="2023-09-13" version="1">MANGFGSRSTPHAASAATCKVRRQDRSERDMSSAKEPVTFAASPDCGTENAADGHFRRCGSSTTVGRSQPYPALTLNSCHNSTGTGYIRDWLHLSTPGWQRFSLCSPRPTRKLRKAVALCYPLPGVVSTIRVRGSRHSASLLRTLSIAPRNLCYLYGESASSWQGGVCYLCIHTALLRYPSLLAMHVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9Q7</accession>
    <name>A0A9P4P9Q7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_489786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9Q7"/>
    <dbReference type="OrthoDB" id="4191440at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="527" mass="59121" checksum="699F5BD37EBB862F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB09</accession>
    <name>A0A9P4PB09_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inner kinetochore subunit AME1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_395284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB09"/>
    <dbReference type="OrthoDB" id="5377952at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048743">
        <property type="entry name" value="AME1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20994">
        <property type="entry name" value="CENPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner kinetochore subunit AME1" evidence="3">
        <location>
            <begin position="453"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="650" mass="71792" checksum="FBE7D9CF36F5787D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBF9</accession>
    <name>A0A9P4PBF9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_369329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBF9"/>
    <dbReference type="OrthoDB" id="9985472at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF43">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2439961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="170" mass="18894" checksum="66E966C6AAC29772" modified="2023-09-13" version="1">MSNIAFKSEFTGDLKQRDISKFSEPMTGTCLCGSISATIHDKGLFGDKPRGHLCHCANCRKASGSFVSSNMAIEKEKVTYEDKNGTLKVYDDWATGSGKCVKRSLCGNCGSPIMSQSEIVPHMYILKMGMFPRIPKPECEGFAEYRHEWQGKHDGLEQYALVRGQKKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBJ5</accession>
    <name>A0A9P4PBJ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cutinase</fullName>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_498843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBJ5"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF1">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2440955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="94" mass="10228" checksum="8BFB470178AF5967" modified="2023-09-13" version="1">MLTTDETFFVASAVLFGDSENGKAVGETKSSRTKVFFHDADRICNYQAVVDSAHLTYSLNMGEATAFVLKGRVLEALASHSSKGQNGVRNRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBK4</accession>
    <name>A0A9P4PBK4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_523972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBK4"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="1">
        <location>
            <begin position="94"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="306" mass="34089" checksum="6895C738A5F07950" modified="2023-09-13" version="1">MVGHAEGGAGALPGRKLLALLPLGVSQVPRHPELSYEQHSPPGVGAFVTQCLNEANEEDFRSFHAMGEARESVPGAGAIVIEKLKKKDKVEGTWFARRSFHEEVSYEELDEVLRKNHERNEMEYTPAIYDVNTLLEWHVEEEIEGVRDVNIRITQMHHSMPAPALFNDRVFTVLLVSFIPTHPASGTLAQSIDLQFPVELTTFPPAIRERSHVHVVNAKHMYKSPASGTLFQKKQDGRKVIEGRYVSLEKIAKVDKDGKVVARWEMATDSDAEGSLPMSMQKLGVPNAIVKDVPLAIEFVIKKRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBW9</accession>
    <name>A0A9P4PBW9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_86698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBW9"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0779">Telomere</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="179" mass="19946" checksum="D37B38662541C530" modified="2023-09-13" version="1">MQIVDFVIWRLFRRSTSYKPSHLLCHGFQRSGGRVQHGPQKTAHSIPGISSHLKNTGVEMLKGPLWCRLHAILGKEGRVIMMDMLTDCGIFSPVERRQGDGNLLQMSGIPISELQPVPPPDGVPPAVPANNFTTRKPNSLTSENRTPNAITFVRNRMLYARAALNAKGGVRFGMRHIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC64</accession>
    <name>A0A9P4PC64_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_364807</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC64"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="552"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2442299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="636" mass="69206" checksum="E7B5EA26F0546673" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCC7</accession>
    <name>A0A9P4PCC7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_523222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCC7"/>
    <dbReference type="OrthoDB" id="3800054at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040363974" description="Mid2 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30715" checksum="2B7D17DD07A92A1F" modified="2023-09-13" version="1">MTAVIGIWSLCHVTPTFPVHPPCIPQGWTGFHATGTLSTGTPSSTSDLSISPTSPLAHVETIVTISMGHTIHTTVTEYSAPTSQPTSDPASTDQHVGHVGNRRHVGAIVGGTMGGVMLLAAAVFFLFLLRKRRHTKEERRATLPPTYPVIRGGGDMSEQLTGATPISSARTKNIANDSAHTSSESIPQLDGIAIMPPNEIGSDALGTISELPADEKHIDPFETPTSEVAEVPQEGNIDGGRACRDPNNHIMSWANLNSTGNRNAMSRLSQPHAIPEGGVWESMRPTNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCK9</accession>
    <name>A0A9P4PCK9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_327986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCK9"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="34"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2440893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="232" mass="25759" checksum="463145BCC3EC8BF1" modified="2023-09-13" version="1" fragment="single">LTMNEDGTWPDLGGRILGATWSICILSTGILIWRIVYGIQSRRKIMICDYLLIVAACLNIASSGIRVKSTIHGQGRHIADPSITKHDFLEYSYYLYVGQVINLIAVAILKLSICTYLLALPFGLAYKLIIYLSIAMVAVFNFMLPMLGLFCAKPFEANWNKSIKGTCFYKGSTALTYMQGVSNILTDVVYIVAPILYLSSVQLSSKTQWGLRLVFCLGLIATICSIFKTVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCV3</accession>
    <name>A0A9P4PCV3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCV3"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="94" mass="10406" checksum="F133214D920BF16E" modified="2023-09-13" version="1">MAVSTNDEAKAILLKHYHLSGTLKELDSRQDHNYLVDTGAKRFILKLCVSEYGLPELEAQVSALQHLRSKPGVPRVPSVIPTTEGETIILLAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEC7</accession>
    <name>A0A9P4PEC7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_433845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEC7"/>
    <dbReference type="OrthoDB" id="5335351at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="209" mass="23559" checksum="69F9B8DA5994A533" modified="2023-09-13" version="1">MPSSKSESPYPSISGLQQRQQSFRSSPPYFPQSSLSGMADVSNDQTHKAEHAENASNAEETRAPSIPADSTEEDRPPSAQQAQQVPEVENLEPGEGEAYDSNDDVDPADEIVDFDWEELHERYHNTISTASAQEQELLEEFAQLMDYFKIWADAGANQESDRTFHRLRTRMTYVQNSEQKLANTRQHYIEVVRAFESALDLLRNSGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PED0</accession>
    <name>A0A9P4PED0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_456506</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PED0"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="129"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2441416.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="603" mass="66729" checksum="D0B5CADC77AA9E6A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEP9</accession>
    <name>A0A9P4PEP9_9PLEO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_366171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="216" mass="23606" checksum="8AAE68DA5778B1CC" modified="2023-09-13" version="1">MSAQAAATRLRRTFQYPSESDDEDAVEAGMDEQDQATLLTTLSTHDTRTTSTYTHLLLVLPLLPIVLYIPLLFHLSTLPAAGLAIPSLLASAYTLYFLPLPPLRISVSHVADLQSPTSARSKPKPTEAKAERRPVPYISEGTAEVVARYIVFANGALCAVLAVAEVLQGRAWGEGMTVRGGYLPGLVFTVVMFARRELRAVDMSELERLQYQSKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4PER6_9PLEO</name>
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            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="442352at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="122"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="393"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2443695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="668" mass="73374" checksum="5206B0F0EC480743" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEY6</accession>
    <name>A0A9P4PEY6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
            <ecNumber evidence="13">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_415748</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="13"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEY6"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040365748" description="Carboxypeptidase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Propeptide carboxypeptidase Y" evidence="15">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2442662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="543" mass="61066" checksum="0F2475BF734728EB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFD6</accession>
    <name>A0A9P4PFD6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_523156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFD6"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="71"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2442318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="532" mass="60569" checksum="1D2DB74558F1690D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFZ0</accession>
    <name>A0A9P4PFZ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_433561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFZ0"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF29">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2443267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="619" mass="69940" checksum="054D0131E842A4BA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGF9</accession>
    <name>A0A9P4PGF9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_67692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGF9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="257" mass="28137" checksum="715E1A530F2AAECA" modified="2023-09-13" version="1">MVRELTKLSKAGETFRTVFLRVCLSVWFDVRTALHARTQLKIQTHDCTVRTELIRAAMVCGLWLLWHGVKRSVHCIARWTCMCEGPVLAGGVLSRTGAVASSAVDARRLRLEVEACRIGTTAPPEVGSKDGEMTPLGPDANRTNFGVTDSSRQVHEACVAKEDMRGWGEERAEGEGRERGSRPGGCWRICSRGWASSPGCRLYTLYPNSLCGLHFAIACPPTLRRDPADACHCIPNNLGACRCDVEKLCSSGGTVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGK8</accession>
    <name>A0A9P4PGK8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_433333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGK8"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="94" mass="10249" checksum="7D1B17FD860D5A14" modified="2023-09-13" version="1">MPETNKREGTWQKLVIARSQTATEISAVSFEQAVLVDFPLQTAVAALHLYLGMEKPGKGTNDENVLIWDAGGAVGSYAGQYAKTVSFKCSRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGS8</accession>
    <name>A0A9P4PGS8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_486466</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="11"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGS8"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000003">
        <property type="entry name" value="Dolichyldiphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="52"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2443745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="232" mass="26756" checksum="EFD8817BE8D23339" modified="2023-09-13" version="1">MDEAPLASLSLTHVHYNPADRVSYLCAWLALVPQGLCVIYATLIWSNREIEIMLMFVGQMGCEALNWCLKRWIKEERPREMHGKGYGMPSSHAQFVTFFSLTLALFLLFRHVPHPTETHTPFSFFQRLVLSVLALVSAATVAMSRIYLNYHTPKQVLVGCLAGAICAVVWFGFTTYLRRAGWVEWVLETELARLFRVRDLVIQEDLVDSGWARWVERRKRQPSLQVQAKKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGV5</accession>
    <name>A0A9P4PGV5_9PLEO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_445056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="250" mass="27519" checksum="75BF54BE97D01442" modified="2023-09-13" version="1">MFATNARSVGRAELQSPASSPRSSPDPDVTEFLRSRAQSEFIFTTQDNHAGEVRDDAAGSDEEAELVLFAGPLQAGESHKIRLSSPEASGESGLRLKKPRAYYFADEVTSEKGEEYRAAAVTGADVLSMAKIPWPGCAVPWKVRTITPAGLKQTVLIGHPSVPVEVEEQTKKRTRKGKKSRIALRKKMQATNNKQAEQARLAQEKEEADREKRTRRNREKKVKRKAREQAKKEVAAGPEEPTPASPGSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4PH04_9PLEO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="194" mass="22442" checksum="18666636C686A66D" modified="2023-09-13" version="1">MLNRWMFVRPDSLEVLFELADAMEQIDELVRFYARGVLALLDVVSEPGACHSNIGLSATEYERIASAFLLSRIYVRYNRLRGNKQLFMDTLHIWQIEQMATVSDFLQGVWLHSGSALYHLVPGEYSRRESACEASRLIWRWFKILVATDTFLRSTSPCWKMQGTTGCLFIVVTMRCYPVFAPCGLWIMIIRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIT0</accession>
    <name>A0A9P4PIT0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIT0"/>
    <dbReference type="OrthoDB" id="5401654at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="55"/>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="287" mass="29947" checksum="7BD3518C1FDC8D00" modified="2023-09-13" version="1">MPDLNSVLVSPRGPTSNPQAASSTTSAQASRQSSTTASRRASQIYPMSPPPLPFASPGGTIPTATTQHAHAAPLSPGFAGNTPSVDATGVPIRHPRPLTAAELHLELEKEQEAVVNRLTRELSALRAHSASVASTASSVTSGVHIDHDIIGSTHPTSVRRHRSSSSVSRTSTNAPYGIPLNPATASIPHHRYSVSSQPATSDPSAAQQARSASVVSTPRYEEVAHYRQELEEAKRENEVLKSRIRELERALRGGDAVDTQRGRTGAPTSAVTGTEAAATSATADAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ23</accession>
    <name>A0A9P4PJ23_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ23"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="451" mass="52046" checksum="99081665C7DB2B58" modified="2023-09-13" version="1">MAPPKTNKYTFLAAVVGAKFNYEPVRKEDKREVEEAEKALEKSKQALAEVKDYNGKCQRTLRAAIAFDHLSKSVIHTYQMGAAKGAAVMKKRGDEVFKELDTECEEIDTKWRDSVKELNAFKVAYDDALDKHRDLEAECNRLQDELNKRAQQQVQLESEHSQLMRDHEQLKDGKAQLQLDKSQLEDEKKKLLHHHEKLKREHERLQSDHAEPWRTVRMHKRTRRLRDFAEQQQQRRQLEKSITELFKFTAKFLGGPNFEKNQNDALQQLRKNMKTWDTSAIADPNGSFTTFVRVLCIAQNELLLGIDQVKLFLSQRTQHMSAMGKDLEDLASDRDDWKAEYAELEKFLDAKEESFAGAKEALKEANRKLQELADTNKELEDTMKEFELTNKVLKDTSKVLEDMNKAFKVANEILTEDLSSKMQDIEVMAGLLGLGDASLRGSDIEREGQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJC2</accession>
    <name>A0A9P4PJC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_473082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJC2"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="570" mass="60128" checksum="829A16AABC25F928" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJC4</accession>
    <name>A0A9P4PJC4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">P171DRAFT_511781</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJC4"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2446140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="175" mass="20416" checksum="4BCFD20EAC3A9464" modified="2023-09-13" version="1">MKAYWYDNLPGDQRAPHDSGRAVSPSTLQQLGILYKHCPSVSDVDEIASARSYKNRDEITVSPQTMGAAYEDKVKSFFHEHLHEDEEIRYILNGAGYFDVRNEGDDWVRIRLEKGDLIVMPAGIYHRFTTDEENFTNAMRLFKEDPKWTPLNRGEETEKNQYRQEYLRSRHTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJN0</accession>
    <name>A0A9P4PJN0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_463648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJN0"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="3">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="165" mass="17769" checksum="18B4CA0A8A4BF50F" modified="2023-09-13" version="1">MAPGERSEEAYLWFSTVCEAVQEIPPGKVTSYAHIARLVGKPQCPRQVGVCLKHLPAASTDPGKKSPEWHDGNVPWQRVINAKGGISPRGPSGAARQAAALRREGVEVTQNAMGEFLVDFGRYGWFPSMLPSEAEEVESSDEEDEDGDVDGDGDEEAADAAAYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJT9</accession>
    <name>A0A9P4PJT9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_485947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJT9"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040144301" description="EthD domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="EthD" evidence="3">
        <location>
            <begin position="84"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="220" mass="24166" checksum="48621B4CBA4D438B" modified="2023-09-13" version="1">MRIATVVFSLFSFPLAIALSSFSPDTNSTTTCVRRLPDFTNCSPSASDDGKQCPHAYTFSEYKPGTESNRQPYFRFMILFKINPDLCEKQAHEHWKTVHADLTLAAKNTGVLIERYVQFHADGASRQAIQSLVDTGSVEVAPYDGIAEFHAKDAESVLKFIGNAFADPVIGRDQAYFTDGRMKYNVMAGYDTLIYGSGIQTSGGTDGILPGDSRFNNGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK13</accession>
    <name>A0A9P4PK13_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_412520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK13"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="227"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2444718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="364" mass="40113" checksum="CF8CF4252F834B8E" modified="2023-09-13" version="1">MPPQIKQDLNRSGWETTDFPSVCERCLPDNPYVQMLKEDYGAECKICTRPFTIFRWKADRTARQKRTNLCLTCARLKNCCQCCMLDLSFGLPIVVRDAALKMVAPGPQSDINRQYYAQEHEREIEEGRGAVEAYDKTDEKARDLLKRLAQSEPYYKKQRRQEAEGEGTQKALPAPGGESSAAGGHAPGPIRTRDSRGPARGRGGRVGGAPAAPSPEDWLPPRDPNVASLFVTGVEDDLPEHEIRTHFAQYGQLRSVVCSHRAHCAYINYVKRQDAETAAETLKGKVVIKGCPMKVSWGKPKQLDSLDQNVRMMYAKEGRQASGNARRAQAAIETAPEASLDSLAAIAPPPGADDEVNYASLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKP1</accession>
    <name>A0A9P4PKP1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1531-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_429800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKP1"/>
    <dbReference type="OrthoDB" id="4227028at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199:SF1">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="143" mass="16590" checksum="263517AC7DD195A5" modified="2023-09-13" version="1">MENVQEFVDSRLRNFTASFSRLKPEGWIRLIWIVGAYMLLRPFLMKLGARAQERQHEKESAEAVDTGAEVHPNELRGGKKIAIPGVDSDDEEEKTEAKPGQWGKKARVKQRKFIRETLVKEEKRLQDEQEQEDLKDIADLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKX7</accession>
    <name>A0A9P4PKX7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_484501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKX7"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF187">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="750"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1098" mass="119345" checksum="23D46CF932771394" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKZ9</accession>
    <name>A0A9P4PKZ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_484928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKZ9"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2444839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="607" mass="68201" checksum="FF862E53FD2604E8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMY5</accession>
    <name>A0A9P4PMY5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_410317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMY5"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="9">
        <location>
            <begin position="23"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2446233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="480" mass="53737" checksum="601E86656B0D2501" modified="2023-09-13" version="1">MELEPKTPQYKTSDPNSFAHTSARSRWPIIITQGIDDVHRSIYATQDEEKVKEGKWIVSELAGLKYELQHDRELSPIPDDGGSDIADYNKELEALKPAKWHSVPWLYSECYLYRRISSIFNRTQNWKSYDIFARQKMSTFKSSRPAVIELASRYRDIVTELESKHTIKGAKTAEELEEAEKVLFMEMCEICLWGNATDLSLLTNLTYEDIQKLQGSEARKKSEKNILVNDLDKAFKILSAAQKQGKKERRVDIVLDNAGFELFVDLILAGYLLASGLATNIVIHPKSIPWFVSDVLPQDFAALIQALADPQGFYSALSDDSEESGTKTPPLSEAEVDALKYLFQHWSTCHAEGQLVMRPNTFWTAGGSFWRLPKTEPSLAEDLKESELVIFKGDLNYRKLTADAEWPATTPFTEAIGPLGPGSGIRVLALRTCKADVVVGLAEGEDERIKATEGGGGDSGSRKWAWSGKWAVVQFSDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP70</accession>
    <name>A0A9P4PP70_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_470427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP70"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040193435" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="982" mass="98900" checksum="1C57387621F2CDF5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP85</accession>
    <name>A0A9P4PP85_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_408885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP85"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31473" checksum="D2DF3DB85F026E4A" modified="2023-09-13" version="1">MPSPPWIQNLLPFPRLLWPSLLLATGIYHFIMTVLETIFLDRQPAKVLNLTQIRYKVFARLWTYNGAAMSQEMPGPLGALVSSCRGRVLDVGPGSRELLGRFNPEGITAMYGAEPAVDLHEGLLNNARKTGFGEKYHALLCGGEPESLIPALHKSGVLASSGTGGMAEDGIFDEICCLRVLCGVPRPRETIKGLYILLKPRGRMVICEHVVNPWRTEGSITARAIQFVYEVLGWSFFLGGCGMQRHTREYLREAGEWETFELQYVQPKNVVPYVVGELIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQV8</accession>
    <name>A0A9P4PQV8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_354440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQV8"/>
    <dbReference type="OrthoDB" id="3925971at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="291" mass="33232" checksum="352BEB9E3DFB4A48" modified="2023-09-13" version="1">MPGFLQPKSHIQHRVAAIALYRALLSRCSSAHALQDEERTSLHNAIRNKFRQNRKLQSSRQLGLVFKAGYEVLGHLDASQNPNSKSIDALKTLIPSLPRGIARSPPRWRPAKPPPDPSARDRCAVLPPEKALLNVRPYAETTGPRHIPILASANGIPFLRIKKPQPPVLSRVIRQALQRRIDNFHAKILFSNYWTPLSNHEDEWDAILERECDFVEKDTRKYGTFDPLWVDEVIKAESANRAAHDKDVQKTTEIAAKMTELIDKETELALQEGRKIVRGRKIKPIRDRWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRP2</accession>
    <name>A0A9P4PRP2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_382851</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRP2"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000290">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001557">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="28"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="14">
        <location>
            <begin position="721"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="429"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2447749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1029" mass="110755" checksum="FFC6011DF8F4F6FE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT12</accession>
    <name>A0A9P4PT12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_428492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT12"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2448409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="347" mass="39921" checksum="7D95F13DBBAED2D2" modified="2023-09-13" version="1">MPTTLKEFESVWPRIAADVAEHAKSYKLPQQPLDWFAQSLDYNTVGGKCNRGMSVVDTSSILLNKPLDPSSENYFQAALLGWMIELLQAFFLVSDDIMDASKTRRGQPCWYLKPGVGMVAINDAFMLESAIYVLLKKHFRQHKNYVDMIELFHEVTFQTELGQQCDLLTAPEDHVDLDNFSLDKFSFIVIFKTAYYSFYLPVALALHYIGAATPKNLQTSLDILIPMGEYFQAQDDYLDAFADPEVLGKIGTDIQDNKCSWVVNQALKKVTPEQRKVLEENYGRKDAQKEAKVKELYQELKLAEFYQQWEEERVADLRAKIAQVDESEGLKKEIFEAFLKKIYKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT95</accession>
    <name>A0A9P4PT95_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_381945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT95"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="255" mass="28057" checksum="FDD024853C835221" modified="2023-09-13" version="1">MSGLRILVPIKRVIDYAVKPRVNRAQTAVETANVKHSMNPFDELSIEEAIRLRERKVPIQEIVAFSAGPAKSQDILRTAMAMGADRSIHVVVEEKDPQLEPLGVAKLLKKVVEEQKSDLVILGKQSIDDDASQTGQMLAGLLGWPQATQASKVDISDKTVTVIKEVDGGVETIKANLPMIITTDLRLNEPRYASLPNIMKAKKKPLEKKTLKDYGLDEQPRLKTLKVTEPPPRKGGVKVDDVDGMISKLKELGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU31</accession>
    <name>A0A9P4PU31_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_467959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU31"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="211" mass="22293" checksum="1F422C6604670FC6" modified="2023-09-13" version="1">MHAAASPDRRRRAVGPTRAVGHGGSSARPPVPRASASGSVKVLSINGLLHPLHPSTPPPPPPPRSLGDCFRFALIAARPAGLPRGTAHHTAISSIIHPPSIPSWRSQALYGFGPSPGPRRNCIQPASSQRPASIAFRELLQNPTARASKPKQPIRHSHHRDPPRTPPILTTGAARKAPTTHHFPIPLAISCASTSVSNVWLALSNSLRGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU91</accession>
    <name>A0A9P4PU91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_479410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="878"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="923"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1012"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1096"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="276"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="603"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="885"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1199"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="830"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2450312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1448" mass="159568" checksum="0535A350871497FA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUF3</accession>
    <name>A0A9P4PUF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_143173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUF3"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="229" mass="25397" checksum="C009497AB43D27E1" modified="2023-09-13" version="1">MRRKSKSLVRPTALAQLLPLLKTRAPPTQRGGRTQLSCRGKDWRFHCIGTFAPLSASRQLIPRETRHVSPSAPTFHPPSKILPLTPSTVKEPRREREAGVCAPVHTLPPQTPHASTYPQQLPKPHRKRTLPSLVYLPAAPFRCLPRRPLYSTLLTRFTQIPPGGTTNMSSLSRRACFKCGNVGHYAGELPFLRGCLEGHCRKCCRKTAPFAVPVSRGHALCNTATGTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV15</accession>
    <name>A0A9P4PV15_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV15"/>
    <dbReference type="OrthoDB" id="5289641at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697:SF1">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24451" checksum="53B2E97A0DCA4BC3" modified="2023-09-13" version="1">MQSPYRFTPTSHSQSQFAVIHLPFSAFQSSTLFSNVYSSISHSINRTMHSPSRDTTDTATASDDTTVYTPPETEKEGPPAYNQDASSVPQPGKTFLIRERESGQLLTLLDGVVRLHPAGTPGSAFHWSCHERNGWMGFKNVAAGRWLGFDPSNTLQATATAHQGWEDFCVRFMPDGGYVLLMTHWSQLWPVKRKNENGVQKLGKAEAPVKHGLVWEFVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV34</accession>
    <name>A0A9P4PV34_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_480425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV34"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF11">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="579"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1211"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1211"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1232"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2449336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1258" mass="137808" checksum="E7C3162E329BAF43" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVA5</accession>
    <name>A0A9P4PVA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_401970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVA5"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="246"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2452035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="39020" checksum="EB81A7815CB53AD2" modified="2023-09-13" version="1">MSHGYQQYGGNPYEGASQAESGYGQSNPYGGHGGQVASGGNGASNPYGGTGQELNAPPLQHENSQYSQASQYSSQPPQQTYSHSATPLSQQDFLARIDGTKSRIHQLSANITEIANIHQRMLSSPDNRSSAQLESIVSETQIRNTSIKDEIKFLEKDASREPQNSFKRTQVESLKRTFKSQLEDFQREEADYSKRYREAIARQYRIVNPEATESEVQEAANADWGDEGIFQQALKTNRSGQANSVLGAVRARHNDIQRIEKTLGELALLFQQLNEQVVYQEEQVTRVEEQTEEVNKDTTHANQQLDHGIASARRARKLKWWTFGIVVLIIAILAAVLGGYFGTRAKNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVC3</accession>
    <name>A0A9P4PVC3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_402032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVC3"/>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="623"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2452064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="730" mass="79744" checksum="77012993C012AE00" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVH8</accession>
    <name>A0A9P4PVH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_479164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVH8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="406" mass="45005" checksum="546632EF7AF1D752" modified="2023-09-13" version="1">MTGERAPQEAVRRDDVANNRCNFTHHPPTSTGFILQKNSSNIRTNTIGHSLGADISSSTMDRAGDRSDGYPPKRTYTRSLNDGSSASQPMIIPSTEPESKYPNASRQLHLPTPSPSLGSEREYPNVSRQLHLPTPSPSLGSEREYPNVSRQLHLPTPAPSLRYERAYLNASRLSLPRMPPNASIYLPLPRMPPNASLQLPLPTMQPPPSYHPADVAGEEAKCKLNRMLFEPSRGQAFAPVQRQQMTVPAPVPAPVPAPVQVSGRRHSFHQHVADTQGPRPSVSAPLHRPVMDSREYDPCTRVAHPSVAAGSVSGAGFSMNTDVSGEIGSTSFLHFHNSHSVQAVWDTTTKRKQKKAKPIKSQSVASREADEEFEQARREWSEQQGPSSRKERRETKRARRDRLERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4PVW3_9PLEO</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_478240</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="3946768at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="236" mass="25510" checksum="48AD844F123DABCC" modified="2023-09-13" version="1">MPLLSESSLSSDPSFFALSLAGYDILNELVHRISEPGPDGTIIVPIKKGIDEPMVPQVIGLEPYNNNSAYVVKIEPAMAADHLDSPDTMVDDAATASCDQESNMPDDSLVKLSTTEYGGLIFSDSKANILCANFYIKATSLKIEATVRVLPKQMLAKERFFVRVAFTTTHSSENSLLYNMRMTSAGSGSSNRATHSPNLKEVTAPGLVTVSPKFLYGLGWTYDTTMAVDIQAGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWJ1</accession>
    <name>A0A9P4PWJ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apolipoprotein/apolipophorin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_8577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3883941at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="44432" checksum="0F5C44F64210584D" modified="2023-09-13" version="1">MLSKRVASEAGALSRAARRPVPRTPVARIRVQNARFQSTSAGQNAPAGTSPALIGAVTGSLATLSIGYVWYRQSGAKELLAATKTTKDYVKAGTKKLKESTPEPNEALDWLRDASKSYAVLIPGASGYIDTAFKDLDDIRSKHGDEVDSIVREAYSELQGVAKNGDISILTAKRAWDIIVKHLGRIGDLAGDSAQQIMDNHPQLKEKVGGNIDKLKEYGDKYGPEAKKEADRTWQQIQDVVKTGLSAENVTKIQKIVQEKVEKMKKLGDEAYQKGLEQAKPYLDKNPKVKELVEENADALKSGNVSELYNKIKKAVESGDTGDLESYVKSAAGKAKESGFGGLDQYLGKIPGGDQIIPKLTQLQEVAEKHGDEAQKIIKDAVSEISEILKKKGSEAEELAKKAKEDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXT0</accession>
    <name>A0A9P4PXT0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_146882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5353066at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1289"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1332"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
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        </location>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="758"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1362" mass="148615" checksum="23E4CC7BB4F77A86" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXW9</accession>
    <name>A0A9P4PXW9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_378270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXW9"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="619" mass="67882" checksum="353805DE55261314" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZD5</accession>
    <name>A0A9P4PZD5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_450765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZD5"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2452113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="61490" checksum="18DAFD2AD7C8F17E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZK1</accession>
    <name>A0A9P4PZK1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_402089</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZK1"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000032">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="853"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="723"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2452088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1084" mass="121712" checksum="B12DA9B9FCCDCFD4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4Z0</accession>
    <name>A0A9P4U4Z0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like f-box protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_178392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4Z0"/>
    <dbReference type="OrthoDB" id="4540290at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040152860" description="Cyclin-like f-box protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="38791" checksum="2684C64ED5BDA775" modified="2023-09-13" version="1">MYKFAFASLVALVACAPQRGGGRKATAQQQAAQVPQGISQATDGSMILDATVNINQLPIRFKIAAPADQFTAASGVPGAAAASGANGTMGVNVLLHGDGGQSFFDFPNQNLQANTMGVALLAPNANLFWGGGSGLDRTDGAAHAQAVADFVTTTMPQLVAFDAANVKFTGVSGGSLLMSGFFIPAQMQNFANSAVELNCGAMPPQVPFADANTVMSSLRIHYQSTQSELTLLQDAIPQAVAAYEQLAADAGLGADQINALQTVDNTPAGGHCEFDGNDFVTGVQTMLTSYSNVVQGGDGVVAGLGAPSTGNVLTGVVGNENLKFAAGGRKRDAGVESMVVRRWAEGLEGRQRRRRQDVVVEEAGVAMLACDRMTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8B4</accession>
    <name>A0A9P4U8B4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_525041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8B4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="87" mass="9009" checksum="A96AC15E41535D9F" modified="2023-09-13" version="1">MSHSTAIGTLRMPMCPCALHVVSATGLRQAAKHKTDFKIAGRDHTGRFGNPEGLSSSGGTIANHTVGKEDIAITAAVVAQYGFGPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8D8</accession>
    <name>A0A9P4U8D8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_435770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8D8"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="715"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="766"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2439942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="868" mass="96326" checksum="AB8E6356D6AC76A1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8N0</accession>
    <name>A0A9P4U8N0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8N0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="17024" checksum="92E73FEA14F650CB" modified="2023-09-13" version="1">MACRTAVLSLPSVARLASSQKAARRLRTPVHGHGGTGRAATRAQQQQSASLRQEEPRPQRAASGTTRKACSGLEARRRAAIRPSAMRRGLALITRGGTQAACTGEKNRRRPGTVGRPRPPSPPQSLSGVESQRRTSRAEAEQPLEKPAVTKYIGTTVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8Y5</accession>
    <name>A0A9P4U8Y5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_390711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8Y5"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="320" mass="36237" checksum="EB8C1C30913EA832" modified="2023-09-13" version="1">MSAQTLTRAAALTRVLGQSGRRYLVERILQDKPGNQGRVYLATSGDHKYVLKSVAPRDFRYFKDMFDDLRSSPYLRVSDDACPDESVFVYKYLRDHLLSFVQNKVPLPITKQILRDALRGIATLHGKGIVHTDIKANNILIEWKDQGGEITVEQVQVADIEDAAYVPIDSVIKGRQVGNWMWRSPEAHASGEVHTPSDMFSFGLVCIYAMTKRVVLAVDEEEIPEGIELLDIVLERQLSYFSDLEGIDGLIRYLGNSPWAQLIAMVAADFNADNPRQPFALWQDIDPDFKDLVVRMMNVDPTRRLTANEALAHKWFSDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U925</accession>
    <name>A0A9P4U925_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U925"/>
    <dbReference type="OrthoDB" id="3800277at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="407" mass="46251" checksum="8848E1BCB2EBBC1F" modified="2023-09-13" version="1">MANFVRMSRNYVNLETLYEIPVQQSWSGFLFMGHGVNLGRLYADTPSWESRTGWGYFEDGSVYLNAKPWGNDMNHASFEAKMKLLEPFVRQLPPQLEQPKSKHSNLSRLLLVDCQPSIKLSESEESCTIFARNAIDGERLTIEWRPFRQCHLTYDRAIPSQPSSRLDQPPVVLHRLMRVLMNKALQNFRGTLVDGVLQPNVWLGNGLNLSDSNVLDRERTITGLQKFLKLGDTRRQSLTWREATISNREAAISRREAAVNAREAAVNTREAAINTREAAINTREAAINTREAAINTREAAVKERETILDEREAALHAAPWYRKVAALNKHEARLHDAIGLETSNQLAELREQLLTQPSPELDSSSTQSVPTSEIQSASQYDDIFPELADFDTPEYRTRITLPRRPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9P0</accession>
    <name>A0A9P4U9P0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_486366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9P0"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2443644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="218" mass="25671" checksum="9F83C65C02EB0F5A" modified="2023-09-13" version="1">MMNLFRLLGDLSHLLSILILLQKMKSSSSASGISFKSQFLYLIVYITRYVDLLWTFYEPKSLYNTIFKIIFICSASYTVYLMLNDYKPTHDPNLDTFKVQYLIGASAILAILFPYKYNFTEILWAFSIWLESVAILPQLFMLQRTGEAETITTHYLFALGAYRALYIPNWIYRYFFEVPRFWDPIAVIAGIVQTILYSDFFWIYYTKVVQGKKFNLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA93</accession>
    <name>A0A9P4UA93_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_474526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA93"/>
    <dbReference type="OrthoDB" id="1938992at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="251"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="457" mass="51557" checksum="052C4D62F75EEB91" modified="2023-09-13" version="1">MANLIRPAADRRTTRRTKSRSPPPAEVAKHVAVHHQQRPPSPISTRRLSKTLPQPAEAPNASDIAPPNQTSPARAGARKRSIAEVDTPDARPQSKSKQRRFHDDLSTWANDATKKLHSNVNVEDTPSGASTPKPDDTPSAMVDKKSLRSKDPVRKASVLADIFDEYDDIIANWNDGESAESNVSSMGSDDQIALVDEPLTAAQLAEFRDNIRQKAAQARADKPPPDPNHVYTERAPVDYTPYATALPTTADPLADSVYTKVHKRHEGEERKSRNREREDLQYKMSKAPAVLEELESDDWHKVFVIDKGARESWEPKRAYFIRELRTAIAKQDALRDIELRKRRREKEKRARERESPDDDDDESADEPRTTRSTAPPPFGVPLPSILTRVDDDVLTRMMREDDEFARRGEPTEDKLLGDERSFQCFELAGGFVTSGFLRENERGRRRRVREGRGGGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAA5</accession>
    <name>A0A9P4UAA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_30526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAA5"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="539" mass="57405" checksum="7231785E0681DB76" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAC8</accession>
    <name>A0A9P4UAC8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_487059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAC8"/>
    <dbReference type="OrthoDB" id="3794517at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040441263" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2443105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="29875" checksum="3C3D3A620FD4B695" modified="2023-09-13" version="1">MKLLLVSSVAVWLLAASAAASGPTKIYIDSVPEYDLLQSCAEHEVSMAYGCGDGSQLTSYACFCYQSSAYYSRMISTRVNSACSKIRGQDSSAVEVFSKYCQLADIEKVTTTGEAALGIETSNTSQDTTDSASSEPTPSSSSTQSTSQPSPASTPARTTPTPTSTPSSQTSDPPSPSPEKKDNTAAIAAGVTVPIVLIALGLVGFLLHHHRRKRNPHAAGELPAHPENQATEVSGAAMTHEKESYRHIELEGGVPQELDSGVARGKLAAADRDGMITHLLANGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAP9</accession>
    <name>A0A9P4UAP9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_331521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAP9"/>
    <dbReference type="OrthoDB" id="3789469at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="69" mass="7858" checksum="63B21B7DC7E352AF" modified="2023-09-13" version="1" fragment="single">YEAVSYTWATEDRDTSLSGVLHCTSGTIPITSNCQAAIRRLRKICAERRLWIDAVCIDQNHIAERNHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAU3</accession>
    <name>A0A9P4UAU3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_434083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAU3"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2442613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="352" mass="38670" checksum="C3E50291BB9BA227" modified="2023-09-13" version="1">MSSFRGRGGNHARRGGGGAWRGGSSAPKGTLLNGVWHCECSPPLPAVHFEVKKAGPNKGKWFRTCQKPQEERCKFFLWDADAHPREAAALASNSRTEPSPETTTTPRAQRVASPPPPYTPEGGPSGNGRKRDRATAQQEEDEFDLGEGNDAFQEELDQVMAAAETPSKRPRTDAFATPSRPARRRLPWQTDTGPQPSALPTPQTESRTSNELFPTRFSAPENSMLTPSRYRSSKDFGTMTPSSSPNETPTPARFKNVSEHDLVRDAFSVLRDANVELNEQTRKNLTAVLSRHATIAEGVKKGRDVARASITAKTAKVTELTYRVSTLEAELEAEKAKVSHLQWTLEHGQQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB56</accession>
    <name>A0A9P4UB56_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_49262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB56"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="40"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2442777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="369" mass="41362" checksum="FC3DA1F334FF193E" modified="2023-09-13" version="1">MSNSTFALMMYPSGDEKARQNVAAGAIITMTIFGIACIALRIYTRALIVRNMGKEDWTMIAAAILTITFAIQLLVAVKEFKLGYSGMSLSMEQAVAGSKLGLSAIVVYKSIVTLIKASILMIYLRLSVTKTFEWLCKGSIYLLFTYQAIVIIIVPLECIPLRKAWDFSGTVPGHCINTAVFYYITSAFHILMDVWILLLPYKLIFSIPRPTREKFAVYAVFGLGAFSTICAVIRFHFLIVSLNSMDPYYDSLGVNVWSVIEVNVGIICASMPTLRPLLSRAQRVRTRHALKMSEQSDKPSTPWSSKRGGLLQVKEMFITLGTVTAGTFKSTRDSVYDVEQWRDEKPPPVPPKDMKTLRLSYPDMAHRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB62</accession>
    <name>A0A9P4UB62_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_388219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB62"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2443915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="525" mass="59820" checksum="12B512698A3AFDFA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBY6</accession>
    <name>A0A9P4UBY6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_520779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBY6"/>
    <dbReference type="OrthoDB" id="3766411at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="322" mass="35094" checksum="0DB47A3AA2C6A632" modified="2023-09-13" version="1">MVGFSFGRKTLWQYSHSASILFAVLLFTAGFLCTLLWTNDIVHTETSAGGSLTGTFTSLSPAVSTFSITYQVAIFGTAWNAILFVTLLILERDDLPISTTRLRYEIEKSACIVAIAGNAIYSVACIALMATLARLAADASSKLRTDIDLELAKKIADSASDRAAGQGVTAAIAGVAAFCALWACFMDELHAQNNNRTNLLRFIKKVSGVLIKFGSEDGDHEKLRQRYMDDILRGLTAKESLCNFEELLRGNSRLLWPPGIACDDRISGCGSKKVCTVIRKDLDGEQLHEDDMLSAASAVENLLALDHYVKIPHDLFKCGEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD31</accession>
    <name>A0A9P4UD31_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_514004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD31"/>
    <dbReference type="OrthoDB" id="2986744at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040147471" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="21670" checksum="53F9920F1B9F9EF6" modified="2023-09-13" version="1">MKFSILLMIAATASAAVVAPRHHKGRKGGNSAAQQGQAAQTGNGATQNAQTGNQATTGGEAATGNNNPAATGGGALARGAATIVLKETLGIPGNECITFRNNGEMVDAACVNTAADRQLQASTVNGQPVLAVQRSFTAGFRQDLVGVDACVGNNGTTFLALPCDDASLDPVTFSNNNLVAASGACQSGHDDAAQITVDQSGRNCAELTSTDTAATPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE98</accession>
    <name>A0A9P4UE98_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vegetatible incompatibility protein HET-E-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_277532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE98"/>
    <dbReference type="OrthoDB" id="4850at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948:SF1">
        <property type="entry name" value="BLL5189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948">
        <property type="entry name" value="ZGC:113208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38174" checksum="970051C9E760AF02" modified="2023-09-13" version="1">MSTLEQRRQENIKRNAILLQELELEHNHVKQQLQPKPLPAKKRRKLNVLQPTRSSARIASAPARPGYNEDNGAIARSGRSSFHGKSSPRNSARKALGEPLEVQSPEPESQSAHPDLESIKAGWNDWEPVACPPTRDAFGTYHFESHPDFTPNKSPADIIREGCFGGSYWRPLYSKSLGITVEDDWRELPAQWTSGLDVEQYLVNPDYNPEVNKHGVACGQSIEQWEANGWIAHEYDVRGWFQWYCRFWIGRRCEDDERQISRWKKCVGNTGRWRRTLLKQYVQRGIRSVFDDGENSDGEGRDVSPVVSQTCLHWAYEVRQEALDRFWMEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEJ8</accession>
    <name>A0A9P4UEJ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_385100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEJ8"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="201"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="476" mass="54209" checksum="DBA19F0AF7BDAA0B" modified="2023-09-13" version="1">MSRGTSEAFFDVVEWAAEQPWSSGKVGLLGISYYAGSQWRVAARQPKGLAAIVPWEGMSDYYRDRCRHGGIFSNNFINFWWNRQVVSNQYGLPGRAARNWGPDCIDGDVSDEEREKNRQDQNIDNLNNRFRDDEYYASKEYDMSDIQVPLLSVANWGGILLHLRGNIEGYLQAGSEFKYLRVITGRHDLPFYYTEEVEVQRSFLDAFLKGDDRVGWSVKGKVPAVDLVLRKGDVGFDDAKAEKVYERRTETEWPIARTRYTKFYLTPEQSLSQVQLMVTRPQKLSYEALGSLESPKLLQFTTPEFEHETEITGHIVAHLNVSMSPLASGATPSDIDLFLTMRYISPSGKEVHYTGTAGDPIPLAKGWLRVSLRTINPSRPRHREWLPHRDYFSTDVQPVIPGDIYPVDVEIWPTNVVVEKGGKIVFEVSSGDTQGSGIFQHNHPEDRSEKKFAGMNHVSFSERCTNWVSLPIIPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF90</accession>
    <name>A0A9P4UF90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_480817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF90"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="112" mass="12707" checksum="096C8F158CFE97DA" modified="2023-09-13" version="1">MTSAMSHRSRLSYPSRTYPSFSTSASHLIHHFRYTFFAGKLLDLRLVICLTHGLLLVSIDIVADSNVKVWASRELRIPAKHLHLRFPTVSHARATLNEDLAFVIKLATTLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFR2</accession>
    <name>A0A9P4UFR2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flavin-containing monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_428814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFR2"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="481" mass="53949" checksum="0EA57F8FCB7A7A4E" modified="2023-09-13" version="1" fragment="single">MASELIPLRARTIAIIGAGPSGLVAAKYLRAERAFDKIVLFEQRSRSGGIWNYTGHQRDEDLFTVPQTNPLGKNQDPTWCERPRPADGTTDGAQKEPSYLSPIYNRLETNIPRGLMGFQDLDWPQDSQLFPKHETVLKYIQDYGIDVQNLIQYETQVTNVEPVDEQSTRWKVQTRDLRSEVQHVEEYDAVIVANGHFIVPYIPDIPGIKAWNAKYPGSISHAKYYRSPEEFQGKKVIVVGNSASGVDISTQITQYSQLPLIWSSKSSSIFNTGTPPSKQERPPISNFLPSDRTVEFEDGSSEHDIDAIVFATGYFYSLPFLSQLSPPPIIDGSHVNHTYHHLFYAPRPTLSFLALPQRVIPFPIAEAQSAVLARVYSGRLALPPLPSMQAWEVATAQEMGDGRNFHLMPFPKDGTYINMLAQWALGAEAREGLENAGAGKKPPVWGDWQFWCREHFPTIRAAFGALGEKRFGVKTLEEVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG11</accession>
    <name>A0A9P4UG11_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP-1 adaptor complex subunit MU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_406762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG11"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="446" mass="50417" checksum="A17B2749D18D0342" modified="2023-09-13" version="1">MASAVFFLDLKGKTLLARNYRGDIPMSAVEKFPVLLSEAEEESSAVPPCFSNEGINYLYIRHNNLYLLALTKRNSNAAEILLFLHKIVEVFTEYFKELEEESIRDNFVVIYELLDEMMDFGYPQTTETKILQEYITQESHKLEVQARPPIAVTNAVSWRSEGIRYRKNEVFLDVVESLNLLVSANGNVLRSEILGAIKMKCYLSGMPELRLGLNDKAMFETTGRATRGKAVEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECIVESHSGSRIEYMLKAKAQFKRRSTANNVQISIPVPEDADTPRFRTNIGTVHYAPETSSIVWKIKQFGGGKEFLMRAELGLPSVRGDDEKGGGMMGGFGGSMGGVGGGKGKRPISVKFEIPYFTTSGIQVRYLKIIEPKLQYPSLPWVRYITQSGDIAVRLPDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGG4</accession>
    <name>A0A9P4UGG4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_480270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGG4"/>
    <dbReference type="OrthoDB" id="3797192at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="52683" checksum="E624CAC4132ACC60" modified="2023-09-13" version="1">MPSSGSYGSRRNHIRTAAGFSSSNSQVGRSRTSTELNRRRRGTATAGDEQPNKDRTRRVLAYYTHAVVTFHTFGIPLSAGLTLEYYHNSLFLETRLSQISLIVGIQWLGIFALEDLAWRAYRWKHWRWTYMAVSLVLVLCHGIIARDAKPWGLSLVMRALTGFCLGFLRSMTLRCLASHYNDNAAEVSMQGGAAGLLGALVHSLVAWTFLRMDNYKGLAWANFYVVLFTLVPTLGGLFPAREQESTDGDTPKRDRQIPRLMHRKSTRATQSLPGKFGMQRNTSLDIIDDCFLLIGLLLVFAHVVVWPIFFPLLLSSRPLYEYPDFAAYWLLGTFGAGALTAAFFARPWPRRGLGVVNTFTAAAILAGSLLIIAAWVANFWVWGIISVLYGLCLGPLLALHMKVFDLLCKYWTKTRLFPFGLGIVVFGGVSVAGLMIQDLGSGSVALTVSGVVMLLGGCCMAVGRWLKYPTKYVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHE8</accession>
    <name>A0A9P4UHE8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_377028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHE8"/>
    <dbReference type="OrthoDB" id="3930719at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2450140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="197" mass="22311" checksum="B297392E7F639E88" modified="2023-09-13" version="1">MSTKVYTGSCHCGDIKYQVRLTLPPNDTIGFDAKREGTRIYKCNCSTCHKLGMFHCRPNDLANDFIVTSPANIQEVGEYRCFAKKIGWYFCKRCGVRTFGMGGEWVPEEIDVAKWAGNEEGQGKLQKVFKSTVTSSGATGYDGKSLHYVSVNGTTLDEIDLIDVHDQGWVYYIENKYKKDGEYPQMRFKQPFKGGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHH2</accession>
    <name>A0A9P4UHH2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_404939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHH2"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040235600" evidence="6">
        <location>
            <begin position="24"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="391"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="4">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2449573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="583" mass="63936" checksum="396B56CD47AE4E28" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHI0</accession>
    <name>A0A9P4UHI0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_451558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHI0"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="226"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="659" mass="72923" checksum="9789BBA657544E47" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHV1</accession>
    <name>A0A9P4UHV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHV1"/>
    <dbReference type="OrthoDB" id="4159838at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="941" mass="105822" checksum="A3E74F62CF8DC25F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI09</accession>
    <name>A0A9P4UI09_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_468989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UI09"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="371" mass="41530" checksum="BC5F836B6E81494A" modified="2023-09-13" version="1">MEYSHITADDGCRLAFQTSQPINCAPAEKDYSNLTLLIHGFSGSSLYFQRNYDQLSKHSWVIGIDLRGHGDSGRPTGGYHVARLAADLKALISHLKNAVPGVKIVPVGCSIGAAILWTYVELFSDDDFAGMVFVDQAPLQDRSTFDSWDESKAHRGCFDEKSMLGAQQALIRNPEDAFKGLVADCLGYRYKPLPGDGASEERKSGDELFFTSQSRRCDTIWYDHREACELIKAPVMVMAGRRTGCFPLDGMKETVRRVDKGQKARGDGHEPRWSVFESGHWLFWEEPERFNEEINQFVATEMNRTPCGFRDYMRALWSSIEDGSREAAHNGRQEPTDETSSVLHMVLAFLITLSRIPIPMGMPSAKSSCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIS1</accession>
    <name>A0A9P4UIS1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_331366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIS1"/>
    <dbReference type="OrthoDB" id="5403157at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="172" mass="18443" checksum="C96438AB5F9DCF63" modified="2023-09-13" version="1" fragment="single">SSPLSPRMDSINIPSQARRRPPLAHMRQSSGTAASLRLPSLPRFHPANFSSQGSSGAGTPTTNPNSPQPPLSPRAHQRHYSEVQRQLYSYQQQIMANAARQARASTKPSSPKLAPLDSPGPVTPMELEGADGYLTARMTSNDAAAHVEKLIRDEAARRGDISPGRTTSVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIU6</accession>
    <name>A0A9P4UIU6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_19189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIU6"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2452106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="513" mass="55426" checksum="8971EFA6F8D7B0C5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ12</accession>
    <name>A0A9P4UJ12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">U2 small nuclear ribonucleoprotein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_401471</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ12"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="170"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2451730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="244" mass="27705" checksum="BD0ABDB58430936A" modified="2023-09-13" version="1">MGDKMEGVVPSGGAVDPKYGVPIETVYVNNLEERMNIDYLKKALDVIFKHYGTILEIVAKSSLRRKGQAFIVFDSEKSCLDAVEEMDGFELFGKNMKVARAKTHSDETIKRKAPEMFDEHKRKRLTQKDFKRAQEDAKAQANPAAAAEKPRASKPGAAALIPDEYVRPNKTLFVQQIPYETEEADLTAIFERFEGFKEVRYVKLRAVAFVEFENEQFSITAKEQTADARVGKDQKPLKVTYQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ83</accession>
    <name>A0A9P4UJ83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_467978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ83"/>
    <dbReference type="OrthoDB" id="3771532at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="196" mass="21436" checksum="739949071A24C042" modified="2023-09-13" version="1">MCTYFTLSYKCGHSQTSHRCPRSTVFVYGKNGEQVPQVNGCDISHVIGAHLHDECIDCKMQEGHMPGVTTGVDKWSQWGPKEEALSARVKMMEAGISDTASPVESGEVQAEDWEEQVRAVLMDTGRGQTGTPEMTTSSVKSGSIQPEWKQGKEGAKNQDEEDDDWMWGGMKSFGGEGGRKRGKATTVRSAGITEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJF6</accession>
    <name>A0A9P4UJF6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1753-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_426134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJF6"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="315" mass="33863" checksum="C25EA96B7750DD70" modified="2023-09-13" version="1">MSLRTGAEIITFLQVINKVSGLYGLLALLTGAAIDGWQLSMYLYSTVVLVATVYLYKHIRMQSSFESLLLAHVYALDSVINALYTTFFAFVWFYTLANHPDGGDNSIAPGVGENAGFTSPKYNVSEVNVVAEPVGGLKAGQDAVAVGQGTPGSAPGLGGAVFQTSSIMSISLIVGFWALRVYFVFVMLAFARQCLRQHIAANASTAGWYNNDTPQTSQNLAENPFQESKEAGAGWKGKLGRIMLSGAPLYWLGSSAEEDESWMRGVGGKFSKKGASTERPIGLGERERRRRSGTGPPAPPKEMRPPPLADLQAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P309</accession>
    <name>A0A9P4P309_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_492128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P309"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="379" mass="43120" checksum="544851B8AB79DA8D" modified="2023-09-13" version="1">MAARKKATPTTSMSSDAVKIKRVIFKQRKVLKGVRALKSSSRESAGLSSERAWEVKKRENGLVDMGKTPPWMVEVAKRNATDSPLLRLPGELRNKIWRYATASNIVNMHDDDSRPDAVVCKGHTVGVVGEDNPIRWLSTRAEDKPRLPTAFHLSEVCRQIYHEVGTLAYSDSIFFFCNWNDEGALIRAWTRTLTSAHRNAITDIAIDDMNFDFYLDYRIKLCSIFLGLQRLHLNTHRVNLVYVLASDEKNGNLVCQKRKRLEDKMQKRVDRRESGGVELVWHDDPIEDYEMWEDTDDDSKADRSFPSVDTTPDSDGSEEDSGPKWNIYTHEEDLEGENETDYQVGANGDEVADSEGDVFSEDDDDDLDYDSEMLDLGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P3Q6</accession>
    <name>A0A9P4P3Q6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_526550</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P3Q6"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
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        <property type="entry name" value="PIGN_N"/>
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        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="30"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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            <end position="760"/>
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        <location>
            <begin position="833"/>
            <end position="852"/>
        </location>
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            <end position="895"/>
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        <location>
            <begin position="244"/>
            <end position="313"/>
        </location>
    </feature>
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            <begin position="450"/>
            <end position="931"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2437754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="999" mass="110990" checksum="4DD30F74B8DC6A42" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5B3</accession>
    <name>A0A9P4P5B3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_373333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029:SF3">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="373" mass="42212" checksum="F3F38716AA318AEE" modified="2023-09-13" version="1">MKLPEATPGVAFIALEKRGVVQKPATPDSLNIEAWSSGYLSGALVVMACITVASMRKGVLLHKLFLAIWRCFWLFLPPPTYSWWLSVGGMLLDASWSLHNVIAWKKVTPFLSRRGSQLFLGTLILAQPFWIMEIYANFTYFNGDNELFLKTRPWEALCRDPWWLFADAVLLWKIKSQYEMSYKEIVDISPRFGIMILAVCLSVVFFILDIISATNTLDLGMPSGINPFWKVSSVFKCLVDCMILDDFKKAMDRLRAYKISHLGSFSQDCSVGDGDLVRRWEEVEADAQQDLGATGSGGVTWVDFQRPADVESSMRSPEHRRPSQLHRGMAWSPRFGGQHPEGGTLDEIHYLEEIVPTALDDDLVKRVEPSHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5D2</accession>
    <name>A0A9P4P5D2_9PLEO</name>
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        <recommendedName>
            <fullName evidence="6">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_505893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5D2"/>
    <dbReference type="OrthoDB" id="2113314at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056827">
        <property type="entry name" value="CBM87_Agd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25115">
        <property type="entry name" value="Agd3_CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25116">
        <property type="entry name" value="CBM87_Agd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040180118" description="Extracellular serine-rich protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 CBM87" evidence="3">
        <location>
            <begin position="28"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 deacetylase" evidence="2">
        <location>
            <begin position="248"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2437547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="67481" checksum="F628A4C5AFC91B2A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5H2</accession>
    <name>A0A9P4P5H2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_173179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5H2"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="65495" checksum="9832D08C396E44AE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5P8</accession>
    <name>A0A9P4P5P8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_437451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
            <orientation evidence="1 9">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5P8"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2437835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="246" mass="28492" checksum="31BE2C398CD67A34" modified="2023-09-13" version="1">MSKQEDAPDGVPNSASAKPPPKPEPPKLDPVYYTWSSTFSILMGRYVTGNRDVPLERNYFEEMDAIKAESYCKRCETNRDYLLQYSPIVKFLKDEVGKLGGDLNGKNIHCRMCTAEQSGGFHVDHGIMLCANKFRNRGHQEDTMAHEMVHAWDHLKYKVEDNNLRHQACLEIRASTLSGECRFAREFFTKNQWRITEQLQNCVRRRATLSMLARPGIKDDVHATKVVNEVWDSCFHDTRPFDEIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5R6</accession>
    <name>A0A9P4P5R6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_437425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5R6"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2437807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="308" mass="33140" checksum="F690BD594A33796A" modified="2023-09-13" version="1">MARTIFVVGSSSGIGLEIVRLFFSKGWNVVAASRNPSASEDLQALRSQDPARILLVALELTNPETFAPALDSAVKVYGAIDVLLNNAGINILGAFELLSEEKLRKQLEVNFFGPAQLTRLAIPHLRSSATKSGKQSLIISITSGSGHFGIPLFSYYTASKFALEGLTEALYHELAPHGIAVKNIVPAGGIKGTKLGPNSFPDAEPLLVATLMGQQPDLSSEEPERKDVLKKYIDNGARTMGKTMILSDQAEGAKSAADVAEAVWGAVEDGESKFRYFVGADGHPFVEAKYGEKCNDEDYMEKVRAFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7B4</accession>
    <name>A0A9P4P7B4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_526416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7B4"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27071" checksum="90708484350D8D51" modified="2023-09-13" version="1">MFTFDEAVFHFVEDVPKISGTLKMCSLLAKTLTRLFTILVTACFWGLSSQHPVHGLSASTVNTEITNLSKRTTYRPFSGPAHNFPDVATWTRYDYMWNLNLAALSTSGNTPTDTAYLKAAIDLCANQYHIDRRLILGIIMQESRGNVGVITTYSGSLPTAGLMQCSGCPGFPGQHGLSQADIASMVCGGAEHFKTNMLHWGDRWSAASVFPALREYNSGNVNEADLSDGRGATASYVSDLANRVTGWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7I7</accession>
    <name>A0A9P4P7I7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_424963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7I7"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="105"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="308" mass="34499" checksum="0534E4FE12431F58" modified="2023-09-13" version="1">MSRRRRWRRSKKLYNPVAKYWADYTTKAPQPVPAGGSIAVPVHKGESIKIINTHGNQVVAIWALAHRNDPTADLFGTARNEAAPIFPNDTVQSASSFPKLANVAAGASREYMSTSHTRSALGRRFPRVSDILVDQKRAPILRLVEDTSPGVHDTLSPACDRWLYARLGIKSHHASCFDNYWDALSRLQTGRNEAETRENNAQKDWVNDKELEVSVNDFCSDSNVFPDPIHLFGNVSMENGPQISGVYSKIKPPVSKAREYVRLEAMRDVVVVLSACPQVDLMINEPDKKPIEVHYEVLPRNNGEQDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7T8</accession>
    <name>A0A9P4P7T8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_421357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7T8"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000012">
        <property type="entry name" value="C6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="826"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111100" checksum="F1091F161CDD5AC6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8A4</accession>
    <name>A0A9P4P8A4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_491206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8A4"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="570" mass="62398" checksum="FADD878DD7993A70" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAN0</accession>
    <name>A0A9P4PAN0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="6">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_109427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="6"/>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAN0"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000634">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="176"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="512" mass="55684" checksum="6958402DDDC355C5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB50</accession>
    <name>A0A9P4PB50_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vacuolar ABC heavy metal transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_447930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB50"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3126" mass="338149" checksum="C6A150516801E5A6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBQ1</accession>
    <name>A0A9P4PBQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_524027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBQ1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF11">
        <property type="entry name" value="ISOFLAVONE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G12510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="340" mass="37302" checksum="2E089F40901A53CE" modified="2023-09-13" version="1">MAKQKVLLLGAHGETGGNILAGLIEDGSFDISCLVQPSSTEKPAVKALATRGLPIVVGDLAGDVDELAKVLEGYDTLISAINTHFIRAQLKLVDAAKKAGVKRFVPCDFGPVIPPGGVKALRDEKEVVHQRVWHAHLPYTYIDIGYWYQISFFRVPSGRFDYAIAFDTPEIFGDGNTKTLLSDKRDIGRFIARIIRDPRTLNHSVVAWGDEITQNEIVALIKAKTGETPSVSTVSADTLEAAISTLAITVKNDPGNGLAGFKLSVGEYSRSKWIRGDGTLENAKYLGYLNARELYPDLKPRRFEKFLEELVEGNATRPYEETLLKDFGGAKERVVIKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBS2</accession>
    <name>A0A9P4PBS2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_434656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in spliceosome maturation and the first step of pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SPP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBS2"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="6">
        <location>
            <begin position="197"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="480" mass="55919" checksum="9AC6E56FED0A9415" modified="2023-09-13" version="1">MATGGFKLSLAGAKGKPGFKKPTEQPAKRRRLALDDDEPEDTDAKQEITGWDAAEGGAVDANKKEEPKGPRVIPALPNRDWREVAQKRQLARTGAPPPAENSNGDNAAQLEQPQMAFGLTTFDKETVPEPMDVDGDVKPEDNRTEEEKLQAEAFEALVNGKPKDQAVIPISEEEAFENDMRDAPDAPDLAAYEATPIEGFGAALLRGMGWKDGDSLSKDKKLAAKPKEVKRRPALLGIGANPDAAVGVELGEWAGPKRGAKKAIQYNPVALKNKRTGEIITEEELKERLAKQGAADAQAERNNTFVGDDNDDDEDERRREKRRERKERDRRDDDYDSERRKGKSRRRDRDDDNSDRDRDRDRRREKKYAEYEDLDRDHRRDKKYRDDDYDYDDRKREKRRERESHRDRSRSPYDDDRRERRRERDRRERSVDSKDRREKRRERSRSRDDDEKRKERMRSRGEDEKRRKRRGYEEEKYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBU0</accession>
    <name>A0A9P4PBU0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0103-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBU0"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="333" mass="36346" checksum="9898BA5813B92FB2" modified="2023-09-13" version="1">MAPAIRHPSHAGSWYTDDGATLSQQLDSWLSKVPSSTTPIGSASATQGGISIPVQNARAIIAPHAGYSYSGPAAAWAYKSADWANAKRVFLLGPSHHWGLSDAATTACSEYGTPLGNLTVDTELVETIRKGWNLKTMSRQQDEDEHSLEMHLPYIYKMLSLHNQTFKSDSSAVPLVPILVGATNSSTERDLGSKLAPYLADPTNLFVISSDFCHWGSRFRYTYYQLPDGSAKELRSSSEVKKDYPIHESIKAVDFESIDAVESGEHRQFLEQLQETGNTVCGRHPIGVFMAAVEQASGLQGDGKFKFVRYERSSEVVSVKDSSVSYASAFAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC44</accession>
    <name>A0A9P4PC44_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_100014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC44"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="136" mass="15152" checksum="05024A1B3765BC58" modified="2023-09-13" version="1">MGVTVATLLLVQRPAGRLESARWGRLVGWLFIYLATWRIAARFAASRRLDENAERAVRSKWRQVESQPRGPGIGFCAMRYNSRQAVTKFIDTSITAGDTAASPQHVLHTALSTRFIGDYSTPVEGENASLEDRTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDB8</accession>
    <name>A0A9P4PDB8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_416227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDB8"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="198"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2442944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="418" mass="46171" checksum="4FF0A468735ACD4E" modified="2023-09-13" version="1">MSTSRIIQLARLIASETQTLDEHLTENKLPQPSFAVGALTEPFPQPSPNVAKAKTNVIEATIELRQLLEGPIKQLLPESNFAPLASVYRFNIAKHVALDGNVSFGDLADKCGLLEQDMKRIIRYTSIHHRVFVEPEEGFVAHTAASRLLVDNELIRDVMGLTFAECWPAHARTPDAIAQRSEEPNISGYSLANNTDLNMFSFLGQHPNRARRFAGAMSSTSKASLDALAEHFDWASLPPGATVVDVGGAQGHVSIDLARRFSALSFVVQDIPEVISDSEGNVPEELAGRVRLVTHDMFTPQPPRDADVYLLRYVLHDWPDKYCVRVIENIIPVLKKGARIVLQEHVLAEHGTLGLLHEMQVRSMDAIMMSLFNSRERGVADWEDVFARAGKGRFDVGVRRVKGNTATGVVVAEWRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDE7</accession>
    <name>A0A9P4PDE7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_433643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDE7"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2442066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="871" mass="96632" checksum="04EDFD05276008BD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDQ6</accession>
    <name>A0A9P4PDQ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">U6 snRNA-associated Sm-like protein LSm7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_464758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDQ6"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000043">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2443154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="129" mass="13723" checksum="F9D005F7C108608A" modified="2023-09-13" version="1">MSERGAFRGRGGGGRGGDRGGRGGGGRGGGAGGQTERPKKENILDLGKYMDKELTVKFSGGREVIGTLKGYDQLMNLVLDEVKEAVIDEEGNTRYRKLGLIVARGTLLVVISPVDGSEEIANPFIQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDU8</accession>
    <name>A0A9P4PDU8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_92430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDU8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040435459" description="Secreted protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9940" checksum="B2FE209012A4B5EC" modified="2023-09-13" version="1">MSRFRIGEVRLFPYLITLAFFPSVESIPSSPTPRCATTWLLPSVARNAPGPMPRGAQGLQREKHEHADAHGALTDASRRRRGWQNGGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE22</accession>
    <name>A0A9P4PE22_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE22"/>
    <dbReference type="OrthoDB" id="10529456at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="388" mass="40054" checksum="C1A6CFD0B1A6E6D5" modified="2023-09-13" version="1">MAPADAARNKEEVQKQGIDTTDDWSRAVKEEEGTVVTYLVTNLLSFKVSGRLVFVLCVPEAHLWTTNIVRDVTISGPVFIVGTDDIFLPSGWITVIGTPSNHNSQGASPGSSVPQISAPVLATAGEPVQTSISPIVTPSPVPNAVPQLGAEPTLSDPTGPCSINTAPPDQQQSSYEECQRTIAPGGICCIPGVPDPSDVPSKTTASTPASAPASPTSTPSSSSTSIPSSSSTVTSKSLTTPTTPPAPSTLPPTSTPPASSAPASEPSAPAPMPTAIVPPKHKTPILPVLIPCSLAAAGIVAFGIWCTVWRSRGPPHQPPPSVDMAPRVVNSQKVFEAGNFAGAEAFEKGIEEMGRKEKVSDEGSGRWKGGYRKYRESGTGSGLLGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFT1</accession>
    <name>A0A9P4PFT1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_445674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFT1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="355" mass="41329" checksum="30CF1DA5C661A34D" modified="2023-09-13" version="1">MSIDIVGRVRQRLANTTLIGPEIDLSFHGKSRAKYIYTQAKAVAHQIELIDYWVEEQQLTKEKFVAGLNFRDADSAIVARGICKSFESIFDTFTHNLQISFQHGGGPADKMQQRFPELWSWTIPRHEIRLQRNKSAHGCGISPCYIEDLVEADNYGNKMPFVATEFWDNVVVNWIPAMREELYDLLFLLQRDLQTMKELTPDKPSLPIETLQKRKPCLPLQAYLPCLQVLIWFFGAILSIYQLLYAPNYATYWCVSLTKRVLTWPLDRTLQFLDADNEIRDAGYRRIDSIHGWFVEEFRDLQWQHAIAEQPEEESEVNWQDDVAFPGEIETSAEHTLEDELNPTWSTEREPGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFZ6</accession>
    <name>A0A9P4PFZ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_432690</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFZ6"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="98"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="198"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2443431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="295" mass="31895" checksum="5CE0213527E2F6F5" modified="2023-09-13" version="1">MGGVSAAVSKTAAAPIERVKLLIQNQDEMLKTGRLDRKYDGIVECFRRTSQQEGVLSLWRGNTANVIRYFPTQALNFAFRDTYKAMFAFKKERDGYAKWMAGNLASGGAAGATSLLFVYSLDYARTRLANDAKNAKKGGDRQFNGLVDVYKKTLASDGIAGLYRGFMPSVLGIVVYRGLYFGMYDSIKPVVLVGPLEGNFLASFLLGWTVTTGAGIASYPLDTIRRRMMMTSGEAVKYKNSADAARQIVAAEGVKSLFKGAGANILRGVAGAGVLSIYDQAQLIMFGKKFKGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG26</accession>
    <name>A0A9P4PG26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division control protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG26"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000039">
        <property type="entry name" value="Cell division control protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="37"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="332" mass="36738" checksum="54EB97F1290DC4A1" modified="2023-09-13" version="1">MPNLDMLLLKGPFPGVEEGLNELRFAILADGIPANSEGMSELRMYIWLILLNTPPLKTDVYLDLVRQGASPAHAKIQNDTFRTFQGDPLFRRRVTQNSITRVLNAVAWRLNDAHEARVNGWQSPPTLSEFGGSPDTAILSRHSLAASVRTDASTTNDAEQIGYVQGMNVLCGPFLYAARSEVEAFTGFERLITQECPGYVRGSMEGVHKGVALVDRVLQVVDEKLYVHLMGYHMEAKIYAFASVLTMCACTSPLPEVLKLWDFLFAYGPHLNILCIVAQLVLMRNDLLNSSSPNQKLRSFPALNAGAIVPLATGFTSKIPEDMYEEIVNHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG57</accession>
    <name>A0A9P4PG57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_495133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG57"/>
    <dbReference type="OrthoDB" id="3800281at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="443" mass="49734" checksum="08DE2596162FAE31" modified="2023-09-13" version="1">MAPTPEPRRSARLAEKAQAKIDPKTHARTPIQKPTRKSPRNLAQKKKKTPSVDLEQIEEQLAARNKKPQPPRVVTSTKKPHRKTPQVIEEPSSEEDSDEATEADSEDEFSMEDDSAESEDEFHENANMSHDHLEFLNSHDLQHSPGRSYSAQSYDSRLEPGNELYEQDDFVVDDEESVVMEYSEDSSGESEDDTDEDDLEINMERDPFRVGYRPVGRSHRASSIFSGVERRRRSSTAISPKTVPVPRRSSGGSYARRRSSSLFVSDRVGDTSISRQFAPWPQTAGDGVEDDVEAPLIEQASEEVVEEIIDAIALFSRRVYRNRPPVRLRLAAAVLEDKETRDALESAIRTGLGRKFSLADRIHSIYHPHPHHPHPRAPPNAHPPQKADTRQGRPHQPPKPPADPRRPSPPEFETPVYPSAGLDACQQEKEEASRHGTPGYAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHT2</accession>
    <name>A0A9P4PHT2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_433469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHT2"/>
    <dbReference type="OrthoDB" id="5428863at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="176"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="651" mass="72842" checksum="DEBCC67C2D9BCDFC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ29</accession>
    <name>A0A9P4PJ29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-terminal methionine N(alpha)-acetyltransferase NatC</fullName>
            <ecNumber evidence="13">2.3.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-acetyltransferase MAK3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_358361</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50524"/>
            <dbReference type="Rhea" id="RHEA-COMP:12713"/>
            <dbReference type="Rhea" id="RHEA-COMP:12714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133379"/>
            <dbReference type="ChEBI" id="CHEBI:133380"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12724"/>
            <dbReference type="Rhea" id="RHEA-COMP:12725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133386"/>
            <dbReference type="ChEBI" id="CHEBI:133387"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.256" evidence="13"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2446004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ29"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000010">
        <property type="entry name" value="Putative N-alpha-acetyltransferase 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2446004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="207" mass="23263" checksum="7A5AD2D90CEBA61B" modified="2023-09-13" version="1">MGDDTDAKGQDGDALQYVQYHGSKEETYLPAIRQLISKDLSEPYSIYVYRYFLYQWGDLCYMALDSASELIGVVVCKLEPHRSGPFRGYIAMLAVRESHRGQGIATKLVCMAIDAMVARDADEIALETEVTNKASLKLYERLGFLRSKRLHRYYLNGNAAFRLILYLKEGTALKRPLGMEPGQEGQMMGGPQKMEEYKGIARDAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ86</accession>
    <name>A0A9P4PJ86_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_486577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ86"/>
    <dbReference type="OrthoDB" id="3720847at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59609" checksum="9D30F4091CAF8730" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJF1</accession>
    <name>A0A9P4PJF1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJF1"/>
    <dbReference type="OrthoDB" id="10480452at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040109485" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="12922" checksum="F30B8DD54DC829FD" modified="2023-09-13" version="1">MKSTTAIIALFMGAPIFAAPILQPSPTTSSSGAKPTAFMPVNYDASYAPKEYKWSLPPPPHSESDLAKRDCSSFNAADRAWIAAHPELASVLEHCESGELYAPPTPTEDHVGACNEWSIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJU6</accession>
    <name>A0A9P4PJU6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PIG-P-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_356613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJU6"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="7">
        <location>
            <begin position="192"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="362" mass="39146" checksum="9FE50524AD3924FF" modified="2023-09-13" version="1">MLPTDLQSQSTPNLPTPRSPAGEKPRIEPRVSATAPHTSLPGPISANDDTEDRDEDEGEDEDEDEDEDELMLGSGDSGESGSDEVDEVDDAPSARGQLFASRSYTQLPHASSTLYPPFYNRPPVPLPPSPSLTSLLRPSFSTTTSRRTTPDSSDVDVPLGTSMPASTANLASITKSARHAPLVPRASPKVPTYEYYGFALYLASSAAFSLYIVWAYVPSPLLHQMGIHYYPNRWWALAAPCWLVALVVYIYVALASYNTGYLTLPMSNCENLVDETAQIALVDKRTGAIVGGQLSASRQAQEKEKAGQGSVTSGRRDSISAYRWSPAEKADWKSYWSVSTDAVMDVPIGGVCEILYGGGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK82</accession>
    <name>A0A9P4PK82_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_430925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK82"/>
    <dbReference type="OrthoDB" id="3162605at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040139788" evidence="1">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="204" mass="21571" checksum="306F60AAD1C8A2DF" modified="2023-09-13" version="1">MKSIFIVSAVAALAAAAPVEKRTPPNIPSTSSATSLLAGLTVKAQGSQDGYSRDLFPHWITQSGACNTRETVLKRDGTNVVTDSACASTSGTWKSPYDGATWTAASDVDIDHVVPLSNAWKSGASAWTTAQRQAFANDLTNPQLAAVTDSVNSAKGDKGPETWKPPLASYYCTYAKMWVKVKSVYKLTITSAEKTALTSMLGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKE6</accession>
    <name>A0A9P4PKE6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_484334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKE6"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="695"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1064" mass="119914" checksum="58E5349EA3FAE595" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKE8</accession>
    <name>A0A9P4PKE8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1750-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_472299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKE8"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046464">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="3">
        <location>
            <begin position="262"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="683" mass="74044" checksum="73E8CBF7429A0AFB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLS4</accession>
    <name>A0A9P4PLS4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_258573</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLS4"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040444675" description="Mannosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2446385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="540" mass="61599" checksum="BEB463D3949E3E38" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM22</accession>
    <name>A0A9P4PM22_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline-specific peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_430812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM22"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040509966" evidence="3">
        <location>
            <begin position="18"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="56"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2445379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="325" mass="36365" checksum="C7720FE55348A2F2" modified="2023-09-13" version="1">MMLLLLVLVVRLLFVHASVSGSNMSEGTAVFKVAGLSEPCQTWYKVFGDLNTSATPLIILHGGPGACHDYLLPLTDLANSRPVIFYDQIGNGLSTHLPSMAGNEAFWSIDLFKDELDNLLSHLGLRQRPIDVYGHSWGGMLAVEWAATPSAAHLRRLILSSSLASMDAWRVGVSALRKLLPRDTQDVLDHADETKEFETPEYEAAIEVFYKRHLSLTRLWPAKEVQAALDWFAKDPTTYGTMYGPSELYISGSLRNWTSIPLLNKIKVPTFLINGAEDEAQDVAMQPFFDHIEKTKWITIDNAAHFSHVDQRQKHMAVVRSFLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPE1</accession>
    <name>A0A9P4PPE1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_452544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPE1"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="442" mass="48513" checksum="8721087AAA9FBE2F" modified="2023-09-13" version="1">MRVQMLLGVASSANMSVYAQNNTTWPYQTYKSLPGFEPPQLEISTVEGSRAPGLIFFPISGSGAHNYSLNIYRQDGELVWQSGYGDYAAFKPTTLFGGLFLALWSSISFPEPWGFGYGIVKILNPNYENIYNPLYDPTQYETFSWIDMHENNITPRGTIHVGAMNVKAWDLTSVGGSENGWIVDSIILELNVTNSEIPLTDAAPTYPLRGLGQNQSYPWGPSHINSIDEFEDGSLLVSSRHYCSIFEIGRDGEHDARIHAEYGSTTLISIFNNDNSAVVSYVNQTTGIFPSADTDTKEATLLLSNGHSVMGYGSVPFPKEFDREGNIVQTVKWGQAQAVQSYRGYKSEWVGTPSSRPDAFACMDSNATINVYMSWNGATEHQSWHVLAGPSKGNPEMQMAINKTGFETFATFSSSARLVQVEAHGAGIETGISDVVAVEEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPH4</accession>
    <name>A0A9P4PPH4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_483957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPH4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="152" mass="16731" checksum="3AA7052F15645348" modified="2023-09-13" version="1">MATSSSYSLSMAPAALPGCYQYSSTSGTQADYLLHLPRAHMRHTAASLESNNSRNLKPDLFSPLSLTPPESVGVGMVRTLDPPKWQARWNRGLAMSLRTSGTEEACLAAPEAWFDGPTLRKEIRKMLRAYLDLRRAEAKLTKGLQEAQTAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPL6</accession>
    <name>A0A9P4PPL6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_429643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPL6"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="88"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="554" mass="62881" checksum="A5BF9423B0702C2F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ51</accession>
    <name>A0A9P4PQ51_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-carbamoyl-L-amino acid hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_409715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ51"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="283"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2447213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="513" mass="55807" checksum="15E3E87B9E8D67F3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ54</accession>
    <name>A0A9P4PQ54_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_242208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ54"/>
    <dbReference type="OrthoDB" id="3800349at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="234" mass="26711" checksum="5CA1B8718AEFD817" modified="2023-09-13" version="1">MSVLALKALDYGADKLPDRIFEAIPGGFFTPDHKKHPKSKTNRRPLRDTRGKSEQRDDRGRRSSQRERTPPSEYSGYSSYNDSEYERDQRRQGRRRRVKSLGRSLSRSASRSLSRGRHQQQRSSGFDGENDERAQMDRERADRGPQFPPPPTSEYRQYNPQEYASPPPAAGGHYDPYRRASSARQDHGYPPQPTSQTAARYTPGAGYAPSPVNEKRWLDNAGARTTWSEPVQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQE1</accession>
    <name>A0A9P4PQE1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_451632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQE1"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2449395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="452" mass="48780" checksum="3D5817C87EC6A5B1" modified="2023-09-13" version="1">MSLFLTNLEIPIVTTSLVSITGDLGGFDNVGWVISSYLLGYVATFGRKLMFSTSIVIFICFSAGYGAAQTLTQLIALRAFQGVGGGGCFALSTAIVVELVPPENVPAAVPALALAIFAIPKNFPNRGRADCPRTTWKEKFDKGSRAKVDVLGAALLLLATLSMTAGFEEADSRFPWKLAYVISLLTISGLLWMDLVIWERHITIYRATIEPVLPWRFFQNRAMLSLLLNAVFLGGPWFVSVFQLPQKFQLVHGSSGVKAGLQTMPFTFAAPLGSAFSALVAGKLKVPVIYPVLFAGTLQTVGLALLASLPESSRIVPRAYGFQIIAGFGCGINILTLLLIVPFVVGSRDKAIGMGAVSQLRVMSGAIGLSIVTSVFNSYTKPRISELLQASHATIDSVQSVQSISNMDPLDQERLKTTLARGYNLKMYVLCAFAALQIPAALLMWRKKQLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQK2</accession>
    <name>A0A9P4PQK2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_452272</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQK2"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="11"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2448410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="645" mass="72276" checksum="F4F8681410B8E164" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR76</accession>
    <name>A0A9P4PR76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Negative regulator of differentiation 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_218231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR76"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12520">
        <property type="entry name" value="RRM1_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12523">
        <property type="entry name" value="RRM2_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12521">
        <property type="entry name" value="RRM3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12522">
        <property type="entry name" value="RRM4_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000047">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000130">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034195">
        <property type="entry name" value="Mrn1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018835">
        <property type="entry name" value="RNA-binding_domain_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10378">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="194"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="285"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="419"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="510"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="678"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="588"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="826" mass="88033" checksum="76F6F08BEA69A322" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS84</accession>
    <name>A0A9P4PS84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_379101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS84"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF161">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="498" mass="55586" checksum="D52054ED8087F447" modified="2023-09-13" version="1">MFSSSNVGLAVVTLILGTFGLVVFKGLYNYWFHPLAKFPGPWYAAISNFSYCLSFLGGRHPYNILELHKKYGPVVRIAPNELSFNSAQSWKDIYDFNGPGKRALIKSNFYEGGTFADQCGSIVSERDPDKHGRMRRFLSNAFSQRSLIEQESIISVVVDGFVDKMVVSAKKGAVIDLTEWFNMATFDIIGELAFGESFRGIETGDVHPWIARITGAMKQGALADTFKRFPMAAKVAMLFLSKAIDSIKLDCKLNEVYALDLVKERASRQSDRKDFLTRILEQRDDTISDVQIAAHSADFVTAGSETTATALSCITYYLSKNKTVLEKLQQEIRTSFDSYDAIDSASTASLKYLNAVCQEGMRIYAPLPFALPRVVSDQGNVVDGHFLPPGVIVSTNPIAASLDPANFKDPLDFIPERWIEHNGHDVYEASQPFSTGPRGCLGRSLGWMEMRTILAKVHYTFDLVLADPSLDWHEESRMCTLWQKPALPMRIQLRAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS87</accession>
    <name>A0A9P4PS87_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_408503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS87"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF29">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040204482" description="alpha-1,2-Mannosidase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="598" mass="67713" checksum="0D91C01F09E06038" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT45</accession>
    <name>A0A9P4PT45_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_406254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT45"/>
    <dbReference type="OrthoDB" id="6038816at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF11">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040389615" description="AA9 family lytic polysaccharide monooxygenase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="21"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="225" mass="23445" checksum="5B6AEC22F97B5C7D" modified="2023-09-13" version="1">MKFFSTAAVAGALFLEAVNGHYIFQKLTANGVQGGVYQNIRPNTNNNSPVTDLASNDLRCNVGGGSGASTSTVSVAAGSTVTFTADIAVYHQGPVSFYLTKAASTAASADGSTPWFKIKEIGPTFSGSSSTWDLEQSYSVTIPSCIPAGEYLLRIEQLAIHNPYPGGIPQFYISCAQIKVTGGGSKSFNGVSIPGHVKVTDSGYTANIYSNFNSYTVPGPAVSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT75</accession>
    <name>A0A9P4PT75_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_407223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT75"/>
    <dbReference type="OrthoDB" id="5319015at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23867">
        <property type="entry name" value="Mmc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mmc1 C-terminal" evidence="1">
        <location>
            <begin position="368"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="631" mass="68341" checksum="83F3D8641F0718C4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTI9</accession>
    <name>A0A9P4PTI9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_480128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTI9"/>
    <dbReference type="OrthoDB" id="4596934at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="54" mass="5964" checksum="9D977703126705C9" modified="2023-09-13" version="1">MAAPGTCTHSWKIIKSDTNIIVWNCNGCHSGPHPFIYECDKCKMISGARALLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTJ2</accession>
    <name>A0A9P4PTJ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_381259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTJ2"/>
    <dbReference type="OrthoDB" id="2519291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="145" mass="16819" checksum="7272414370927651" modified="2023-09-13" version="1">MVSKQFEAGYPNTTGFRKVVKATIMVKKKEGMSDEDFIQYYNNHHAQRAVPILQRHGIISYSLTYHLGRDRKMIQDIMHNQAQLLDYDAICTFVFPDYLALAKFMYDKDGAAMSGDHDNFMDENQMRMMVGDEYMLIENGEKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTK4</accession>
    <name>A0A9P4PTK4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_426636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTK4"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="88"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2450181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="463" mass="52444" checksum="BC6DC1DAC5B2C5F7" modified="2023-09-13" version="1">MASNGASPTAPTRASPSPPTSAGSNLVEQMNAVHSQQASAPAPTTISSKDPKAAAAAANDMNIVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLVNTLFNTSLYPPKERKAPSLDISKTVAIQSISADIEENGVRLRLTVVDTPGFGDYINNDESWDPIVKNIEQRFDAYLDQENKVNRMNIVDNRIHAVVFFIQPTGHSLKPLDVEVMKKLHTKVNLIPVIAKADTLTDEEIAAFKARILADIEFNKIHIFEGPRYELDDEETIAENAEIMSKVPFAVVGANAEVSTADGRKVRGRRYPWGVIEVDNEEHCDFVKLRQMLIRTHMEELKEHTNNQLYENYRSDKLTSMGVQQDSSVFKEINPAVKQEEERSLHEAKLAKMEMEMKMVFQQKVAEKESKLRQSEEELYARHREMKEQLERQRQELEEKKTRIEQGRPIEEKGKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTL2</accession>
    <name>A0A9P4PTL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_427340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTL2"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF27">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="511" mass="57339" checksum="58D34B08CC44DCF9" modified="2023-09-13" version="1">MASSLLSIVVTRNQNEKPPEHHVVTRPSVFSPWASTSTGEKIVGKRSRSREKSQPENDSIASFKNPWPSFHKPTRRELWDSLAFGADEDPCIELAASHAPEALTDGPRKENRDKQAAQLLQIEKPDFSFDGDKYRSKSTWLGHASMLLQLPSLETGGSPLRVLFDPVFSMRCSPSQIVGPIRSYLPPCKLEDLPPIDVVLISHNHYDHLDCETIKDLWKLHSSNIRFIVPLKNKKWFTECGVPVDRIEELDWWESASITAAEPSDAQLHITCTPAQHGSGRESGDANATLWSSWYLEHRAGHGKSYRVFFAGDTGYQFHSDPSWPPRPPSTATKTDPEQSVAPNHPKSRRTRSKDANQLPPKYPPCPAFAEIATRLGPPHLLYLPLALGATWAYLKSFFSNYLPDSLDPFPRHSPGIAGAIHMPPWDAVRVLREMTDNAAADLKSDRPVAIGMHWGTFVTDQTEVLKTLGQLEWACDQQDVDFLRSREELQEKDEQHACFLALNHGQSVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU43</accession>
    <name>A0A9P4PU43_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zn(II)2Cys6 transcription factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_222307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU43"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="466" mass="52068" checksum="2B8683DB0C36BA1A" modified="2023-09-13" version="1">MGEPRSRQRRFAPRSRQGCLTCRARRKRCDGQRPDCQNCTRLNLSCEYQAPRRITADAASPQDSESSPDSTLTAGPLLPSLDPWDTLPGDEIGEKKHLLRYYVDAFVPSVSVATTTSSFYTGLYIPWAFECDGMLDAILALSSAQLARRSASTDRAQHLRAVSARHQRKCHAFLADRVPETGGPPRDAYQVIGIILLLVGLEALNGDKSTRWLSQMKCVRGILQMLGDPGKSWELHSLRRHFTYHNAMASLMARVSKNEALFVYDDLTLACEPNTPLVVDPLMGITYYLCSLISRIQYVSSTNPAFPQISSAAFAVIERDIRQWTYGSPIGLAGLDLPQALDLIALAEAYRLAALIQLYRTSPAHKTLIPPCASRAMEFISRIPPGSPAESSLLYPIFLAGAELDNEPEISKCFKRLAEIQQRNCYENTSNVQKVLEEVWRPALNGEQKRDWEDVLQEWGWSFTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUA2</accession>
    <name>A0A9P4PUA2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_193343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUA2"/>
    <dbReference type="OrthoDB" id="72726at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36674" checksum="B0EF7C8BC52E7902" modified="2023-09-13" version="1">MPTTFLTLPLELRELIYEEVFSSITIRHGFRTSSCNRTALLQICKQIHQEAWRHLPLNARFHFRGTETLLETLLSVDQAVVTRIRHVRIKSFPFPLYNSGRPDYYPTYNFCNALSLLPGLHLEQLIVEDCFHGFGLVDTWRDVVTYFDIEGLIKCDAWKELVYITPNTDFIASGYDHRRKRVAQPEHWDALLKEKDGEQSGAEVQMWITPENGGRSAQENAGTRPWAAQPGNVVIEDLSLATPDQDLRGEVRIVARRGRRAPYIQMGLSQNKTWKELKAKEGGFTQDGWTPYCNDMADAIGWIYGGWGRRVQLANAALNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUC2</accession>
    <name>A0A9P4PUC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_479667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUC2"/>
    <dbReference type="OrthoDB" id="4160219at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="557" mass="58798" checksum="B287A2AD9BF1DF66" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUH2</accession>
    <name>A0A9P4PUH2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 13">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_139958</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 13"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUH2"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF24">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2450452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="226" mass="25882" checksum="B0C8A2435AC2C263" modified="2023-09-13" version="1">MASNKPSARSDASQLRIQYLTFYNAVFAALWSAIGITAFIFVFLGSSKAEIFREVEPLARWTQTLTLIEIVHAGVGIVKSPVSTTAIQVLTRCIQVWMIWWCFPSSTASSDAFFVLVLVWAAADAIRYLYLALNLHRKASKSLVWLRYTMFYPLYPVGIGAEWWLMYRSVVPVRKVNAALPYVWYFLLALYVPGAYTMFTYMVKQRTKIIGRRKKMGYRKDASLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUZ4</accession>
    <name>A0A9P4PUZ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUZ4"/>
    <dbReference type="OrthoDB" id="3941101at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="271" mass="30235" checksum="09BA44701754622C" modified="2023-09-13" version="1">MFANTDQPSGEMLAGRPSTLLAALPEDQVPPYDATEAQREELPDYEPAPSYHCETHEVRLHTYYLRAPDRKSLMAVPYGPSSSGSFKITSRSSRLFSKKPDMDVWRSIRASAPTEDEYVAGIWFETDGPIPWCPRARFVRQDATEGNQTYKMEARNFSDWTISVDGTLYSWILEAKPFSLVLRQGGRQDEVARFTFSVRGLIATGGAEVGDLTIYQDRLSQDKAGVDVILCGLVTALLQFKKMGKHYRNEPGAIPQRAALPGSEFLYIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV14</accession>
    <name>A0A9P4PV14_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_427512</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV14"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000158">
        <property type="entry name" value="Cytochrome P450, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2449306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="501" mass="57054" checksum="65F52B75E1CC6DBC" modified="2023-09-13" version="1">MNFGETRVRSSAHVAHDLAAAAFAITVSYTLFYLIYNVWFHPLKDFPGPLLARSSLLWRIIHSTRGRMHLEIQAQHRRYGSVIRVSPNELSFASASSFKAIYGHPPSGQAIPTKDEFYDMYGAAHNEGCIGSERDPQKHNRMKRSLANAFSTRALVEQEPIISNCVDMFLEKVDSMPDARTKGLDMTHWLEMVAFDILGEMSFGESFGAVESGKPHFWSELVVRHVFVATVLDNLRRYPSLVTLGKWVLPWLTTSVKNKHSGYTRAKVQKRLESKTDRKDFLTNIIQKVESGEVSHEELVGHASTLVIAGGETVATEIAGMIYYLTKNPKVYERLSRDIRQAFKSYSEITSAASQRLPYLQAVIEEGLRMYPSGALGFPRKSPGIRVDGHWVPQGVEIYTSSWTTHHDPQYFHEPESFIPERWIDSDCTDTKEASQPFSLGPRGCLGRNFAYVEMNLILSKMLWRYDIELVNQEVDLPGQGRMHVMWWKPPMYIRFLPRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV63</accession>
    <name>A0A9P4PV63_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV63"/>
    <dbReference type="OrthoDB" id="5311681at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="552" mass="62678" checksum="A225CED092204DCD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVA0</accession>
    <name>A0A9P4PVA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_516806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVA0"/>
    <dbReference type="OrthoDB" id="3792974at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040509613" evidence="1">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="127" mass="13889" checksum="5E750C82C2886D19" modified="2023-09-13" version="1">MKVSCFGLFALTTPILAGTCTKDPLGGKGYYCGQVVNKSGRQLRYTTDPSLSSSRPNKCKFWNWVGHDEPINCTQKYLANGKTAGSGYVTTPGVDVDGFTFADVEYDYDGQRITRGVWIKISSNGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVF9</accession>
    <name>A0A9P4PVF9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_380247</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVF9"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="10"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="689"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2449958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1079" mass="124711" checksum="040012690E1F233F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVM2</accession>
    <name>A0A9P4PVM2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_460895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVM2"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20185" checksum="9AAB184C03568152" modified="2023-09-13" version="1">MTSYHSGRPPAGLLIAQALGITASTYLLGSNATIAFITIPAVMEAPSPLAAKQWAKVYNLGKPFGIGCSVIATACTGFIAYNQDRAFLPFKLNTAAALIFPAIIPFTILVLKPINDKLFAKGDALALDEKAEVGVAQEETTKALIDRWTKLHLVRTAITGVGAILAIWAALDKRETGSVGGFSLQSGANRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWM5</accession>
    <name>A0A9P4PWM5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_144201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="156"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2450688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="651" mass="72933" checksum="FEF4651B42D2FCFC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWU7</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">P171DRAFT_146616</name>
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    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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            <taxon>Pleosporales</taxon>
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            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2450793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="143"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="874"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="910"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1078" mass="116112" checksum="6FD5110FB5C52AD9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWY7</accession>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="FMO-like"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD_binding_8"/>
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        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX19"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="60" mass="7105" checksum="6354558FACC63694" modified="2023-09-13" version="1">MTHRRLGIIGCANFVFFPCTLGLLNQSSRFSYLFKLPNTSFASFARQEKQMMLRRRFVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYT4</accession>
    <name>A0A9P4PYT4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_478729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYT4"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="49253" checksum="954A7176FC8FC41D" modified="2023-09-13" version="1">MAPMPQLQRRYSVTGLTPPEDVPQVSKQQHSPKLQALDTTVQSTPSCGLCDPGVDAAKASVLHVEDVEAATTHEGGRGRKISHHTVRRMASKRSATQLPSPSTPTAHQLPSKIAKLGLESPDMYVDFDMSDTGELAEDVFTDNPWDVGSICSQDYGRLQLDIPPSSPCTIFSGLSDGPLGEPFELDKPYDLDTPYNSLYHSSSDSGVENIVLDTTYDTDVESLALTPISTSSPSSSSIPSPTTFLTLPPELRHEIYLRLPDLVHTQPLIYCLSTFNNAMQHPLASVSRQVRTEALAIFYSYNTWTIKLEFNMMYEAFRDWIIRLGDGAAQLRLVTIAVRGKLFKPGTSHASTTTNTAAAGLNLAVLPGAPAYALTVEQYCPPDGDACFALDLSEKYTGGRVRVVRNDGTGEAAETALGWLRGNVAVLWERRRAGTLNGQDWVDFVDAFLAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZM5</accession>
    <name>A0A9P4PZM5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_426266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZM5"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF10">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2451814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="493" mass="56912" checksum="D19B390BDA063E87" modified="2023-09-13" version="1">MERHQRIVTQVASKVKEYFTRKESFRINHGSTNSTRPSLKKRVVDIGDLRNVIKVDTASRTALVEPNVPMDRLVEATLPHGLVPPVVMEFPGITTGGGYAGTAGESSSFRHGFFDRTINSVEMVLADGKIVKASEQENVDLFRGAAGAVGTLGVATLIELQLIQAKRFVKTTYHPTRSLAEAVRDIRKQTEVPENDYVDGILFSKEHGAIVTGEMTDEIPADHKPQTFSNPWDPWFYLHVEERTKNASSPVVEYIPLAEYMFRYDRGGFWVGRSAFSYMSFPFNKYTRWFLDDFLHTRMLYRALHASGESNSYVVQDMALPYPNAEEFMNYTDDKFGIWPLWLCPLKQSPQPTMHPHTKGDLKDDQMLNIGLWGFGPRDRKKFLEKNRDLEKRLGELGGMKWLYAHTYYSEADFWKQFDREWHEGLRKRYNATTLPGVHEKVHVDIEKLDTLAKQDWGMRLRSIWPLGGFWGLWKSIQSGDYHISRNSTWRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZN2</accession>
    <name>A0A9P4PZN2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_468270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZN2"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="238" mass="26573" checksum="8E3C756FDCBBB78E" modified="2023-09-13" version="1">MGRELQKKKNKSSIPKLRHNQPSKKKILQNPIIAANWNQKETLSQNYARLGLTARLNHATGGVEKTIKTLGLNDGNSSRADAAAGSTADALNIVSSKPQIEEVEEMEVERDPETGAILRIVGDNKAKENPLNDPLTEILGDDDEMEWNGFAMVPSERSDNPVIRQLEAAARNGARKAPRGQSQREVEWLERLVAKHGDDYGRMSRDAKLNPMQQTASDIKKRVTKMNENKGNERKVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4Q0F3</accession>
    <name>A0A9P4Q0F3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_438827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4Q0F3"/>
    <dbReference type="OrthoDB" id="10542147at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="271" mass="30285" checksum="EB0C4E30CB33EB61" modified="2023-09-13" version="1">MYGTSEQLRLDRVELGRQRRMYMRQGSGTSTFPHAEAFFPGITFLYGEKRVVNTQQHLADALPVILLVRGVGTGKGRCENGVGDRDSSTALKGAEENSKKKEIEKEKKKKKKEKVVTDRLSKVDSPIATTSQTSMDTAKRTTTTQSDSAVLGQTQTLPSSNSLTVGTREVLKSLSSTVDTEECFLFLPYETYKSVSATVLSNDEEPNHLRIVLTPNPQDIYTWNNPLSRQSATVISRPIESIEEYKVPYYGYSIAYRAGEFIRIPEASLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4Y5</accession>
    <name>A0A9P4U4Y5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_437612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4Y5"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2437525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="233" mass="25575" checksum="6B66C321022AAAA3" modified="2023-09-13" version="1">MELMGNKGYNNISSMGSNTSKGPGMSMGGMMGTFSTSTRVTLFFSDWTTDTPAKYFGTLIFIFVVTLLNRFLGAWRSQLGHKWANDAADARRKVEQRRAYKLALNRAKLERQSSETCFEGGGEDSSTEKAPLSPYPPGIDVEANGRKRSGTPKWMAVFGGRWRAGNPWRVSIDVPRAMLEGIRALIGYILMLAVMTFNLGFLLVVILGIVVGELILGRYISGTGWEEGGCHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6Q4</accession>
    <name>A0A9P4U6Q4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LPXTG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_490473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6Q4"/>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040346922" description="LPXTG-domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37852" checksum="9608E9C832AB8850" modified="2023-09-13" version="1">MIRRQIYSIALFLQVIAGLEVAPNSPCAKKCLDDPNKGNPSWTNASLTFGPDLACMDGNYVGKNATKVGKKFADCQTCLQSSGWDDEESGERDTTWFLFNNRGAADYCLFGRFAEESNDDISSTEPYKQCFSACNPIYAASDYRVKSDPESYSYCDSNSNYTSNAHSCIKCLYDGKGLTILGNIVATLTELCNSKPGKNIDFDEDIYNTTQIKLSATSPNSTSTSLPPVAPSDSDSGLSKGAMAGIILGGLVAIAAVLAGILILLRRARKRRETKTIEMPDSGTSPTAVPNFSYQYTPIQEHKYVQGSAPGAVKPISELATTGNHVAELGPTSPMHEASELGAGSPYRGHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U773</accession>
    <name>A0A9P4U773_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_434614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U773"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="469" mass="52596" checksum="A04504B36A3DC763" modified="2023-09-13" version="1">MTASRGEAGNTLSRCARCMTYGPIIRINPWEVHIDGQIDPAFWHVLYSQSTKLDKDGWYYSGFGSGLSTVATSSSELHRARRGAVSSYFSAGHVRKYEPMVLAQVSKLIARLQKCSSNDEVVDLANAYRCLTIDVVTSFSVPDPRKMLELDDFGKGSNGLMRGFSKLITLQRHMKVVIPLLELIPDWLVTAVDTSGSFRQLMDFRISFQKAAQQALDRKGKPPPGQEPSNLDTLYSASELAQNDKVMNYFVEEATNITGAGTETTASTLGLLTYHVLFDRDVFDKLLTELSALAGNNTELMELRMLEKLPYLQGCINEALRLSNPVTGRLPRFNPRAATTYTTPDGKTTYTFPPNTVMSMYMPDLHFNASIFPSPHTFNPSRWIDTLPEHLKEMHRYFVPFSKGSRSCLGIEVAKMELVLTAGNVFQKLGRDMRLWETTKRDVSWAYDFFAPYIPVDSKGLRVKIGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7R0</accession>
    <name>A0A9P4U7R0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_524452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7R0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040198035" evidence="1">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="225" mass="25586" checksum="3592BE9BD66E6DCF" modified="2023-09-13" version="1">MLFEASRSLLFLIAATSGRALAELNTSEPIRPCPGPAASIIQYYYTYKHACDRLVKEIQDNNGLPPCLATATAHYWTSFIDMGNGTYMDQYVPYTFAIEGAAACQENANTTKSYCDSAFGRLNWEGHEPARKAGELCEATQPPLPRPSELLLHYRYEFKGSVYRVTPGKPEYNDWRTRIAEELRYPESVYNLTLKESGNERLVFWTADAPRPKTNISRRSTRLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7U6</accession>
    <name>A0A9P4U7U6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_524540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7U6"/>
    <dbReference type="OrthoDB" id="3796157at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="330" mass="36595" checksum="5D59685C4B95A0CD" modified="2023-09-13" version="1">MAMSILKRYSSSFTHAGSASTPSPAVDKPHPTGAPFKQDSFSKKLHGFAFTKPIRIPLHKRSHDDTAQIIDASDVAVHAAYREKDTTAAQKEKARKAHMTTKSRVQSLRDFFGIASPAFDALEDSEKEEYQTWHAYVMQEKEMRQRYEEIAQEPADIEVMLRGWRVDHPPPRLSGLVLTLVTEESAAQSSGISRSGYSELPPFSRDIIWNSIVLIPTPPSSVSCQICGKSRNPGRIAFYGRGYHIVATGDALGVIPCLEPLLHYEFRVLRPSRHAHLSATVWLLLKDAIVVTAHTGVDQTTQVIAIKSCSPDDLLVLLSVVQDNLQSVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7X9</accession>
    <name>A0A9P4U7X9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_489037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7X9"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34529" checksum="185AFD873B25FA87" modified="2023-09-13" version="1">MRTWNRTAGLEPIHVFLEDKVLLTGFVPRPGLYENFLAEMNSETRSLEDLARLLNEAITVSAFQCIRMTEKDHNRISLIYELPSNIDHSRDPLNLATVLKSNIRASNIGSSRGGLTVSLPSITKRYQLPKTLISAMYQLHLASWMHREFSAKNVMFFWSQPKTSPSGSRLPYDMSMPYIDGFKNSRNAVHGLSPSATKRTHKLPDFLAEKVYRHPAYLLHKTKRWSRSSPHRSCHRFRHDHYALGLVLLEIGLWSPLSELEVDVFRDSSTSDRIGAFDHARPSEPIGGGDAASGTIQLSEDWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U884</accession>
    <name>A0A9P4U884_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_524964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U884"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="90"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="350"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="595" mass="63863" checksum="0AA01DB52673E8C3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8K3</accession>
    <name>A0A9P4U8K3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_457116</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8K3"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2441305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="315" mass="36210" checksum="DBE63686E8EDD7C8" modified="2023-09-13" version="1">MPRSDDATYYHDDPAWGDVTPLAQDDGGLHPLASIAYTDEYSEAMGYLRAVMAANEYSDRVLALTEHIISMNPAHYTVWLYRAKALRETGADLAREIAWLNPTALQHLKNYQIWHHRQTIVDVLGSPAGEADFIATMLEQDSKNYHVWSYRQWLVQRFDLFASDDELRWTEAMIDGDVRNNSAWNHRWFLVVGGQGGRLESRRLVERELEYAKYAIRKAPQNQSPWNYIKGVVRAAGLPFSTLTDFALEFADMRRPDDIYSSHALDLLADIYADNEGSKEEAKKALHLLASRFDPIRAHYWNYRKALLEVPETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9I6</accession>
    <name>A0A9P4U9I6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_415004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9I6"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="199"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="428" mass="47733" checksum="DC5539450F591A6D" modified="2023-09-13" version="1">MAGALSCELVNDKVRINGDLRISFKRTIRVPDGGEQVSYLPPSLGNFPLQKISQYETKLKKDMVAKGGIFFPMHQSEAMWIEFNCSKDTAYHIKVYVGGVNAISGEPVIETLATRLRRQEKFRRGKKSLQDYIVVPGQPWLDGIADSNGIVRQFVAMPFGSGHSVEMQVTGQDTAGGIQIEVTPHQRHFLRRPLEPGDMPIVIKTLTGKVIPLSVFRSETIAVMKYRIQDKEGMLPDQQRLIFSGRQLEDDFTLIDYNIQQDAEIHLVMRLRGGGFGPHPPPQEMNIAAGGKIKQVIHKDTYENEWLSDQSTVFNVQILNSAAYQAVTGNPPPSKPISAQTYAKNGMPFFAMYEEPSGISGAFSMVKSVAQIDGVKDKNVKLPIRHIGEDGNRATQAVGIVNPKGPMREFRTERDLKKEYSGYHVANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAU8</accession>
    <name>A0A9P4UAU8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_415251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAU8"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="326" mass="35200" checksum="3C069A8B087E8763" modified="2023-09-13" version="1">MSLGRSRLLFPRVSRIRDFSTAAHRRQTYPTTCSPTCACAGTPPELDIDHKTPLLHTMAPYTEQVLLCTGKDDWTSRIEDEESSAGDFVRGLRGEIGRGGKGFDPFTNVLTTLSSLPASTTPNTTTALLFPSFKRIPAIPNTKDAHAAFATAYLKARTLHPAHAGLSPGQKAPLTRDESLASRLPAPVPITKPTVLICGHGGRDQRCGILGPLLQSRFREAFRARGVDAEVGLISHIGGHKYAGNVIVYLPPGMQGNPWAGAGIWYGRVGPDNAADIVDKTVVNGEVIFDLLRGGITKDGRDIARMLEPPREEEGLKLRPKARARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAZ8</accession>
    <name>A0A9P4UAZ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_362174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAZ8"/>
    <dbReference type="OrthoDB" id="5410741at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6955" checksum="87FBB78986FE8E65" modified="2023-09-13" version="1" fragment="single">FKRNKISLYPYPPYSLDLNPIENIWAILKDRLNKRPRGSLGYRTSSESIGLYIRAIKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBH4</accession>
    <name>A0A9P4UBH4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_28826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBH4"/>
    <dbReference type="OrthoDB" id="5430717at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="649" mass="71814" checksum="DA6B509DD32E60ED" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBP3</accession>
    <name>A0A9P4UBP3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_414443</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="798"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="1001"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="13">
        <location>
            <begin position="1020"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="14">
        <location>
            <begin position="1424"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="221"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="337"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="613"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="745"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1289"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1523"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1306"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1380"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1523"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1538"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1563"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1577"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1624"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1643"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1683"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1693"/>
            <end position="1708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2444425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1715" mass="189062" checksum="F29AC4934A09DC47" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC33</accession>
    <name>A0A9P4UC33_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_359320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC33"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="177"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="683" mass="75268" checksum="D6351A5642C41120" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC77</accession>
    <name>A0A9P4UC77_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_433008</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC77"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2443842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="450" mass="50273" checksum="DA6C3994637CB560" modified="2023-09-13" version="1">MREVISLNVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKAEEEDHGFSTFFSETGQGKYVPRTIYADLEPNVVDEVRTGTYRSLFHPEQMITGKEDASNNYARGHYTVGKELIDQVLDKVRRVADNCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKCKLEFCVYPAPQVATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGIERPNYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYSPVISAAKAAHEANSVMEITNACFEPNHQMVKCDPRNGKYMATCLLYRGDVVTKSTHDAIAHLKTKRTIQFVDWCPTGFKVGICYQPPQTVPNGDLAKVNRAVCMLSNTTAIAEAWSALSHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVAADSLEGDEGVEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDI3</accession>
    <name>A0A9P4UDI3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide lyase family 20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_518899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDI3"/>
    <dbReference type="OrthoDB" id="3889489at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025975">
        <property type="entry name" value="Polysacc_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14099">
        <property type="entry name" value="Polysacc_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040379477" evidence="1">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="288" mass="32586" checksum="F11AFEDF15A8E2F2" modified="2023-09-13" version="1">MLAQVITLAMGLLPFTFAAQEFVNHGIKSGWPSTYIDPKSKGYVEDSTSVFYGGSQSIKFGQEYLGSSYTGRYHAEARYPNGYKRDEEKYYGFAFRLHSNWEFDPQNYNLAQFGADFSDIKWNGKSCDDFSPTTMIWINGAKLFARTKHGQMIKGQSCPPDDQKWNCDLGANCQPTDSFQLQSATSNIGQIKAGVWYRLTFHVKWKSDNTGVFQAWLNGTQVADRSGVKTTLLDDHREYEFRVGLYANSWHDDGEMVGNQAQRQLWIDEIGVGSTFADADPDEIRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDL3</accession>
    <name>A0A9P4UDL3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_430615</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDL3"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="26"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="351"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="473"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2446466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="560" mass="63663" checksum="4322220FC2F39B18" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDY5</accession>
    <name>A0A9P4UDY5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_409025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDY5"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="221" mass="24910" checksum="69AC565332242607" modified="2023-09-13" version="1">MLQRTLFRASRQAARPVQRIQPAFAPITRAAPAIRWYSDAAPAEAKKEVEAADQTKDASAQLKEQLEKKDKEVIDLKDKYLRSVADYRNLQERTKREIQAAKDFALQRFARDLVESVDNLDRALTTVDSAKLTSENPDLVTLHDGIKMTDGILISTLKKHGLERFDPSVENEKFNPNVHEAVFQTPMPDKEDGVCFHTQQKGFLLNGRVLRAAKVGVVKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEH2</accession>
    <name>A0A9P4UEH2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_354115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEH2"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000637">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein Upf3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="470"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2447441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="606" mass="64179" checksum="2384C85E6ADE5D2C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFV9</accession>
    <name>A0A9P4UFV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_406438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFV9"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Galactose-binding domain-like"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043534">
        <property type="entry name" value="EBDG/EBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041351">
        <property type="entry name" value="Ig_GlcNase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536:SF1">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18368">
        <property type="entry name" value="Ig_GlcNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040189451" evidence="4">
        <location>
            <begin position="23"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="7">
        <location>
            <begin position="62"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="225"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Exo-beta-D-glucosaminidase Ig-fold" evidence="6">
        <location>
            <begin position="771"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="903" mass="101732" checksum="4DF9EF1AB94105D8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGB8</accession>
    <name>A0A9P4UGB8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_440748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGB8"/>
    <dbReference type="OrthoDB" id="3801350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="643" mass="69655" checksum="ACE772362D2833C2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGR7</accession>
    <name>A0A9P4UGR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_508712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGR7"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF194">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="454"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="557" mass="62375" checksum="87B00D799AF6EF72" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHD0</accession>
    <name>A0A9P4UHD0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_517156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHD0"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000577">
        <property type="entry name" value="Proline utilization protein PrnX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="469" mass="50678" checksum="89D0BB68CA9856DF" modified="2023-09-13" version="1">MPLTILTDSEVRALLLGLKKQDILDLQQSLADALHYYSTSTDQDHNGCSSSYQPYSTSLKRSDGQTTLVMPASSNDGLGVKIVTFSEPGSVKGPSSSNASTSSACGSLASFDSLSLSAASTSSSATAVSIPPDSLASKDSTTPKGLLTLLDRSGGPRALINAEEITAFRTALASTMLFKKRDNVHDVIVFGAGRQAYWHIRLALLLRGPEIHHLNVINRSFERATNLIQSLFKGPDGTGTDLPWPKVQIITPAAQEYERLLKATIRASSVIFCTTPSLAPLFPAGHLTNPEGRKKGRYVAAVGSYKPHMLELHPDILKQNVAPDHNRHYHKHALQGGAVVVDSVEACLKEAGEVIQAGLTGNEVVEIGELIMLRRDADRKRQECVARKSMGSLDDMGVEIGECEQRKKKKRKGRKVKEEYAGDEGLMEWLQKGNVIYKSVGLGLMDVVVGSELVSLADSRGVGTRINNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHF4</accession>
    <name>A0A9P4UHF4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_427454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHF4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="89" mass="9943" checksum="6FDF3319A35E1F41" modified="2023-09-13" version="1">MSSKVTRGATNKCGISSSVVLVSLLTRTLGLFNTTHLQLDLIIMRRRALAQNTCQFGYRREKSQPFTSRVPLFASTGTELKVRGRLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UID8</accession>
    <name>A0A9P4UID8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF336-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_152296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UID8"/>
    <dbReference type="OrthoDB" id="2276076at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052517">
        <property type="entry name" value="GlcG_carb_metab_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309:SF1">
        <property type="entry name" value="PROTEIN GLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309">
        <property type="entry name" value="SLR1406 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="148" mass="14909" checksum="F222F1A6F1F00F72" modified="2023-09-13" version="1">MPTKSVPVLTLQGARTALAAAEQRAQEIGVPMNIAVVDNGLHLLAFARMDGAKITSIDIAINKAFTAAGHRAPTSVYKDAVWPGGPAFGINTSNGGRFTTIAGGVPVVQDGVVVGAVGCSTGTPPQDADVAGKGVEAVVKTFGTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIP2</accession>
    <name>A0A9P4UIP2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_515855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIP2"/>
    <dbReference type="OrthoDB" id="3801166at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="391" mass="44146" checksum="C7F3CB540C659A2D" modified="2023-09-13" version="1">MPPLQSAAATPAASEEVVGRSTRPKPTSEDAVVGSKRACSTPLPRDKDDSAASGSDAESVNESPTKSRRHDDRDPFPVDQVGLLSLAPRAQLEGSPAVKQEPPDDETTFLHDRSLANATDIKPELSKIRIKTESPMDTIESGSADNMASGSYIKQEQSPPDSVDQEAPVTDPNFNPEIKREIKSESLEPVDLHPERDVSEPHPGDEGNEPGSEDEEEEEEERELVEPGSDYTFDSGKRHIPFQPRHDELAEGLEYYHREVLRIYEDTHPDASSYIFPVGRFRGMRVTKVPAWYVVEKQAWLENQPRAFQDLREALTWRGLKANTNRWMLDARWNGHHWIPERLGPFLYSTTRAVQKIPSLEEYPCTCLTCGWRFQNSTPNRAGSYIDERRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIU1</accession>
    <name>A0A9P4UIU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dopa decarboxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_376751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIU1"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2452091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="523" mass="57975" checksum="0CC52172A1ADAC6A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ10</accession>
    <name>A0A9P4UJ10_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_478245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ10"/>
    <dbReference type="OrthoDB" id="3764847at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="151" mass="16627" checksum="DA09A9986C48A345" modified="2023-09-13" version="1">MPIPRPSFLSCRSRSYDADTKTFERPGTRCLGTRSPHSSARKDSHSTSRDKLSPLAPTFGPRRGIVPSGTLDRRRRGPRYVPFVDQRLLATPGIRDVEPPMGDAKQIVPVAIVISGDEGRRAVWEPGWGYVEVDPASSAEDIEEAVEEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJL6</accession>
    <name>A0A9P4UJL6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aryl-alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_425948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJL6"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19146">
        <property type="entry name" value="AKR_AKR9A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2451447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="384" mass="42939" checksum="A7A49924FF5C43F0" modified="2023-09-13" version="1">MSLFGALPQAKSLLDWHRVLSPNAGVRVSPLCLGAMNFGNAWEQAMGKCDKKTTFEILDFFHEQGGNFIDTANNYQNEESEIWIGEWMKGRDVRHEIVLATKFTTTFPDPTKSTPRQRINFAGNSTKSLHVSLEASLKKLQTDYIDLLYVHWWDFSTSIPELMQSLNHMVQRGKVLYLGVSDTPAWVVSKANQYARDHGLRPFSVYQGRWSASERDFERDIIPMAREEGMALCPWGALGRGNFTVDGKEKAGEKGRNFGPQTEDQKRVSEKLATVAKAKNTLITSVALAYVMHKTPYVVPIVGGRKVEHLKENIQALGLQLSEEEIDDIDSAIDFDVGFPMSFLFGFGGGKYKTSMTTSDLGLLKFAGPLDSHPHPQPVKPHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P2S8</accession>
    <name>A0A9P4P2S8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_437927</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P2S8"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF3">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="351"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2437245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="679" mass="75457" checksum="81030AA8EDB11E00" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4M6</accession>
    <name>A0A9P4P4M6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_437326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4M6"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="551" mass="62152" checksum="56E434C7D780F233" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5X4</accession>
    <name>A0A9P4P5X4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_491341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5X4"/>
    <dbReference type="OrthoDB" id="5320938at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="356" mass="35968" checksum="FA9409ADEB069BBB" modified="2023-09-13" version="1">MRYQSALALGALAAGQAAASGNHGHANFHKRHDVKARGADAVNWDNVAYDLGAVDWSKVEYGNSAASTPAATPTPAAETPAAATPAAATPAAETPASSQPEVVATPASEPSSSAAEAPSSTKAAAPAETSSSSDPIGDLIGDVLSGIESFATKLGAQLGVNSKTENGQIWIGGNGKHSATFTNSADKDAMVWCWGKSTMWINANQPLISIKLAAGETQKLSVADGFSGGCGASFDDSDLFMGLLNESILEFTFGSGANGCFDISREINMKGIQLTAKGAKCTSGLDGGSQACTFICTDSSASRCGEGGGDYAIDVGTSTDGPCMVGKDPFTGDAAGGCQMADDGEHLEVTIHGARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6K8</accession>
    <name>A0A9P4P6K8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_449871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6K8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="147" mass="16208" checksum="F9D2F5641E88F9F7" modified="2023-09-13" version="1">MSSRRFFPTRLCRQACKSTFAACCSLALEMTARPRWRRRQGGSALIARATADTMASAVKIDNCCESELLHPGGDGYSSDISQQHEEDAWMNDARGVCSSGVGWKDQRSKAETSVMIVDSSPARGYMDGLRWPQLSCSLRGISHGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6Q5</accession>
    <name>A0A9P4P6Q5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_423491</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6Q5"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040442438" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="134"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2438347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="364" mass="39823" checksum="1702287E9DF16AE2" modified="2023-09-13" version="1">MLFNRLLPAALALLPALVAAENVVELTPTNFDDIVLKSGKPALVEFFAPWCGHCKNLAPVYEELATNLLHAKDKVTIAKVDADAHKSLGKRFGVQGFPTLKWFDGKSDTPKEYDSGRDLDSLAKFVQEKSGVRSKVKAKLPSQVVILDDKSFQEKVGKDQDVLVAFTAPWCGHCKNLKPVWEQLANTFANEQGVTIAQVDAEAENSKALAKEQGVSSYPTIKYFKKGTTEALPYEGARAEADFVEFLNTNAGTYRAVGGGLNAIGGTIEALDSIVTKSKGAYASGLEEAKKAAETLQDKYAQYYVKVFEKSSKNEGYAEKEYKRLQGLIGKGNLATEKLDDLISRSNILRKFLPVGDEDEKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7D4</accession>
    <name>A0A9P4P7D4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cenp-O kinetochore centromere component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_436626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7D4"/>
    <dbReference type="OrthoDB" id="10050372at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT MAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2438692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34641" checksum="9C872261D9146846" modified="2023-09-13" version="1">MATAEALDDEINDLRDRIATVQAHRANLTSILLSQPHFPTRLEQRPVLHERDRRNAVKLVQKQSNRNLENIYRACAGVTAYKVKDPDPCAVDNGNILGVRIEVPINGIFVETYHVLFNRPNATHRTMLRIHKHTIPPCIPLQPLANKWLPVTKKSAEEPREQDLVKFSRHLRKELVSWHLRLEALEKLRKDARLPDRTAPQDGSKVETEIEMVLNAFVSDDEDSEVEDEATQQQQDGALKILRVDGDAAVREITITWSNGRVGIFRVTKDGEVDKVAVRTKEGTRDASLSSKALGRIEGLVERLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7D8</accession>
    <name>A0A9P4P7D8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_477170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7D8"/>
    <dbReference type="OrthoDB" id="3800893at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="674"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1093" mass="124275" checksum="D80ADFFF275EE541" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7H6</accession>
    <name>A0A9P4P7H6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_491412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7H6"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="15"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="200" mass="21732" checksum="47C35C5FBAC42892" modified="2023-09-13" version="1">MALGTYINRKPAWRQLFALQWVQAYIELFGGDPSRVTISGESAGAGSVMLLDIAYGGTLGTSLFVNSITASPYLPQQYHYKDWVPSQSYYAFAIAAGCPPTWAYGNSSQTIFECLISQSTGTLQNASELVSQSGTFGSWAFLPVTDDVSIHDLPVDWETLDAHGTTGPTTLNVFDYNYKVRRGLFFNVVVAPGSQIPHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7V2</accession>
    <name>A0A9P4P7V2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_467031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7V2"/>
    <dbReference type="OrthoDB" id="2110578at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040318464" description="Heme haloperoxidase family profile domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="31436" checksum="A17EBB3C17414D26" modified="2023-09-13" version="1">MRSFKSLALMGCAVAAQNMSVCDKYTTALLMENNATNQYTLLTLLVNTVVIGNYTQPNKNAVPGILAKGTYEGEDVNLLPYFDGTLKSSNRGGSSGVSINFLDGGGAAPLMENKPANNETSNQYFLLTHLYQFFGKLLACSTYGSMGFPAYAGHDMASAHAFMNLDPSELGYFIQQVGLAATSFGVTEEDVTAVATALNKLFGYRCSPPTTVIPEQGATLNSICQNDKCPLDAMATCAAYPNNGTAMEPKPASMSNGTMPSSTGMSPSATSTMGGPFMGAAVSERVGYAAVVGGLALALAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8V6</accession>
    <name>A0A9P4P8V6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_436175</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8V6"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="496"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="241"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2439530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="628" mass="70215" checksum="38E0A688176E6A10" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9Z9</accession>
    <name>A0A9P4P9Z9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_435936</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9Z9"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="41"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2440145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="500" mass="54340" checksum="38925D89AC3A62D3" modified="2023-09-13" version="1">MAGYSAIGPEPTDTDPMSSSTGSLRGRRRGRGKTLTGHHGQATWISSVINLVNTILGAGLLAMPSALSKMGIFLGIFVIAWAGLTAGFGLYLQTRCARYIDRGHVSFAALSQLTYPNLSILFDAAIAVKCFGVAVSYLIIIGDLMPRVVEGFAPQAGEISFLVDRQFWITAFMLIVIPLSFLRRLDSLKYTSIIALFSIAYLVILVVAHYIKGDTLSERGPVRVFQWSGPVSALAAFPVIVFAYTCHQNMFSILNEIADNSHFRTTSVIFASIGSACALYILTGITGYLSYGDNITGNIVNMYPAAAASTIGRLAIVILVMFSYPLQIHPCRASIDACLKWRPQRRPQGEDSPSRHTLIVGAPSARGSKPREMSDLRFAVISTVLIVLSFITAMTVSSLEKVLAYVGSTGSTTISFILPGLFYYKISDPDSAHHQKLVKDEDDEDDFDSADAEGYVMSDAHKSRNWRRGLLRQLSLALAVYGACVMVTCLITNTFLVAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAC0</accession>
    <name>A0A9P4PAC0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_95240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAC0"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="661"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="837"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="796"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1016"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1108"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
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        <location>
            <begin position="1016"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1140"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1150" mass="127217" checksum="A218BCA38AE10B84" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCA5</accession>
    <name>A0A9P4PCA5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase acuF-like C2H2 type zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_392751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCA5"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase acuF-like C2H2 type zinc-finger" evidence="2">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="502" mass="56700" checksum="ADE469239A32E739" modified="2023-09-13" version="1" fragment="single">MAHSVAERCRTCISTLRLIVSMLTTTESLGRISCAQATEQLERLSLWTGNIGALHPPTSSLSVEARLREADDVRHHVSELLDDLSDASAALYEIVSGQRDGETEAQTDDVSVDEGDVEVSEEIELLQEIDACITRLFRVSSLIRQATPSSPFDKALSRNRYRFNDQFDIAHVGEKFPKLAREDNHWLQTRLGRAITQRRHYLSYTQDHRDKLEGDPARERYSEAGVTQSIEWKQKLPTRLLAETTSQPSTYHTKASTLGPGQITRSMLSTEADSDPEDDARSYTTIARSLDGALESAVTVKIPKLEDLQIGSNKDIECPFCFRVKRFKNNKVWRRHVFEDLRSYVCTFSECDAPLFGNINDWFSHEMKHHRVDFKCSVCQDRSFSNGTNSSGRDKYITHIQRRHPQFLEADGLELLLQSSQRPVEHILARACPLCFGWENRVIERAQADGSLSKPHIEEDEVSVLPHVFKRHVAAHLEELALFAIPVGSALGDNVDSNAAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCJ9</accession>
    <name>A0A9P4PCJ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_365795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCJ9"/>
    <dbReference type="OrthoDB" id="3524154at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
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            <begin position="62"/>
            <end position="354"/>
        </location>
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            <begin position="404"/>
            <end position="450"/>
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            <begin position="610"/>
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            <end position="104"/>
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        <source>
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    <evidence type="ECO:0000256" key="4">
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4PCL3_9PLEO</name>
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        <recommendedName>
            <fullName evidence="6">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_69234</name>
    </gene>
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        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
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    </reference>
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        <text evidence="1">Belongs to the peptidase S9C family.</text>
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    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAF2442540.1"/>
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    <dbReference type="OrthoDB" id="416344at2759"/>
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    </dbReference>
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        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAF2442540.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="727" mass="81003" checksum="2C1F5220EF172E42" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCR0</accession>
    <name>A0A9P4PCR0_9PLEO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bills G."/>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="235"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="474"/>
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    </feature>
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    </feature>
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            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1551"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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    </feature>
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    </feature>
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        <location>
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        </location>
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            <end position="151"/>
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        <location>
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            <end position="712"/>
        </location>
    </feature>
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        <location>
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            <end position="958"/>
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    </feature>
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    </feature>
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        <location>
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        <location>
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        </location>
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        <location>
            <begin position="1524"/>
            <end position="1551"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1551" mass="169770" checksum="03A1463BCCA5C2F3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD06</accession>
    <name>A0A9P4PD06_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_89959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD06"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2441118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="203" mass="22677" checksum="9A9AAB0AA36D3E1D" modified="2023-09-13" version="1">MEVLLGITGKDFTLIAASKAAMRGATVLKASDDKTRELNPHTLMAFSGEAGDTVQFAEYIQANVQLYSMRNGMELSPSATANFVRGELARALRSKRPYTVNLLLGGYDNIADKPTLYWIDYLASLAPLPYAAHGYAQYYCLSILDKHHHPDIDFEEGMKILRMCTEELKRRLPIDFKGVLVKVITKDGVKELDYEDDANVKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDR5</accession>
    <name>A0A9P4PDR5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_524072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDR5"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040377757" evidence="2">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="40"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="231" mass="25274" checksum="0EC81D0DB5AC9D52" modified="2023-09-13" version="1">MFAHLPTALLLLLCTTSASTLSLHTPRDSQASADYAKDALFKSTILNVTNTYRKQHNATSLKWNDTLADFAKDWSEKCNFEHSGGPNGENLSSGYPNASQSIIAWGHERVDYDFKKGEFTHETGHFSQLVWKATKTVGCGRTECDGQDKGKAPGWFVVCEYYPPGNVIGSFVENVQAKVPRDEQPDGPSDPDVPEQEPDAKECPQGGDCSSGVRMGVSSLAVAVWAAVWWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE85</accession>
    <name>A0A9P4PE85_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_497865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE85"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="69"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="211" mass="24492" checksum="26D15A21CE958A8D" modified="2023-09-13" version="1" fragment="single">MNTASSVSTKTQDLKPFIYQPLLATCEIRILVLHPAGSFDNPLEAHLQSRSLPQNYGEIVNLKEFPGPYEAINYVWGAADRTFDLICEGRLLKVTRSVDTVLRHLRKERQSRRLWIDASDRQALRRQALHNNPICNNQDDMVGKGPQITPMDRIYGRAVEVHAWLGEATPEDDIPIGLMRMIRPYIHLFHRMLSRPWFRQRWILQEIVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEB9</accession>
    <name>A0A9P4PEB9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_433934</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="351"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="692"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="887"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1062"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1273"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="893"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1117"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1130"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1240"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1279"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1315"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2442440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1343" mass="150222" checksum="2DB495DEB57E5A26" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PES9</accession>
    <name>A0A9P4PES9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_464853</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PES9"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="13">
        <location>
            <begin position="275"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2442018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="398" mass="41103" checksum="AAD1E48F46CBDC2F" modified="2023-09-13" version="1">MSSLPPVYIVSAARTPTGMFLGSLSSLSATQLGSHAIKAAVERAGLKPEDVQEVFMGNVLSANLGQNPARQCALGAGLPESVVCTTLNKVCASSIKALIVGAQTIITGNADIVVAGGAESMSNTPHYLPNLRTGAKFGDQPLVDGVLKDGLTDAYKKEHMGLQGEECADEHGFNREQQDDYCIRSYKKAIAASEAGWFKEEIAPIEVSGGRGKPAKLVDQDDEPKNFNESKTRTLRPSFKPKDGTVTAANASPLSDGAAALVLVSEAALKQHNLTPIGKILGWGDAAQNPSKFTTAPALAIPKALKHAGVEQSAVDAFEINEAFSVVALANMKLLGISEDKVNVHGGAVALGHALGASGARITTTLLGVLREKKGKIGCAGICNGGGGASAIVVESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF95</accession>
    <name>A0A9P4PF95_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF95"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="189" mass="20927" checksum="D6072079F36A4691" modified="2023-09-13" version="1">MSNLHISNSELRLATATLAALSVIVPAFYFLRGEKAQQATPQLQTFHKLLKAYTTLRPAALGANASKDFSHTVLPLSLNLPPRSLENFQQHAVMIFSLFENFKMEPHGQVHFSKETNTVIAHCKMGGKVNAASEMGKKLIDGGITDWWTECVLFVKMSPDGTKVVELKEFVNSAKAEELQRRLSGVLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGX0</accession>
    <name>A0A9P4PGX0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGX0"/>
    <dbReference type="OrthoDB" id="10631003at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="265" mass="30685" checksum="80226F7BA308523F" modified="2023-09-13" version="1">MASRHTIPEQHAINAVCTLIYQLFLILASAAQRYDISDIEALSDMENSQFWLKLRANSPLELGAAYALPDAPPSIQRAIVMHNFCNYSWLLMRDWLVDLLRIVNPTIRVDVIQVIPKPLLELYVGWQKSFTHTVIRITTTHGRFILDLTAEQFGFENATLLPESKYVKLYTADQKIYREAGAVGEVRLLCAYSSPGNSWWHQARRDLERLEREWKAGLPGDEIRPQDLVSESERGFLRGRLREMVYWGIRDRAACRSPYIAYKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIC2</accession>
    <name>A0A9P4PIC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_37394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIC2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="102" mass="10839" checksum="DCA9D957FEB1D911" modified="2023-09-13" version="1">MEYSTQLESVTVAEAATDVDTSAVTWGSRPHLSNVTGRRMSSSCFQTRRGCQINYNPDPDEPACSTAPPLLCTPARAHLHHSISLSLAGSAAPRARSLPTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIM0</accession>
    <name>A0A9P4PIM0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding module family 50 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_432842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIM0"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF1">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="246"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="38064" checksum="2EE6654EFF3E72D4" modified="2023-09-13" version="1">MYNNNGYQQQGGYQQDSRQGLANEYYSEGQGPQYGGNQQNHNQPPPQYQQHNSQYGQQPQHHGGYTSPPPNESYGQRDPEYGAPQNFDGEENSRGFLGAAAGAAVGGYGAYKLAGPATGHNKTSGLVGALGGALSGHVIQDGASHWKDKHDEKKDEEKWEKEHEKQHGGRRDSNERPREGHFAGGFTRSSRDVRLDAHGEYNLHAQCRRADGEWQGSTLSLNRILENEDGSFRWSSGGRSAGGSSEAITVQPGDTLRAIAARHNCDFHELSRHNGIQNEDMIYPGQRLEVPGGGNSAGGGGNFGASARNVRLVEDGQVLEGELRRGGDWVTSRIVLDERIGNKDGCLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIN5</accession>
    <name>A0A9P4PIN5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_280828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIN5"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="165"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="264" mass="29012" checksum="15542A550B1E5CC5" modified="2023-09-13" version="1">MKTVVPRIRRGYPTVGRVIDNSFRHTNQHSVPDSCHPSHYTSAPDDALALLHAADHVSTEPHLPIAMDNDGVSGADTIQRLSAIPWCCALLESPQWTRTRTSSRVPKASTEDALFAETLATQRTIRSCTALRPTEESTIGEGEACYDELRVIYEIGEGVSGWPKIAHGGFVVTLLDESIGMLLQLNLGLKIEKGVRPIEGANVFTAYLNTTYKKPVPAPATVLCTVRLIRRERNKLYLRATVEDGQGTLFTIGDAMFVEVKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJD9</accession>
    <name>A0A9P4PJD9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MAPEG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_454709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJD9"/>
    <dbReference type="OrthoDB" id="2421200at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2445047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="21500" checksum="C4E67A66AB54D987" modified="2023-09-13" version="1">MSDDKKQKAKHVAAENGVVNPGGVAILGAAPLYLALIPLTSYLTKPNSVVQKLSETLIQLVPGVGISSISSGRAIPAISAIYLFWTFGASGAASAAGQAMGREEGFDNDHPRKHVTKLDGLPLRLRSAHYALMENFPGFALAAALAQVIAPTDSQVVNLLGFHVLAKLLVHYPAYLANIAVPRTLAHISATSALINVCWRLATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJL9</accession>
    <name>A0A9P4PJL9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_25331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJL9"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="56"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="373" mass="40916" checksum="9B539F69F1A85F44" modified="2023-09-13" version="1">MSQSTPSTSSSMFLIPAMPPPPGTQSNFTDPETNATTIRILNGLFLGLAFVLLLVRLFIRTTLPQNHKLGWDDWLCTVAVVASIVHTVLVYLVLELGYGRHFWDVQAISITHGKLVIFALVDMAYVVAVFLIKFSILLLYHRLFAIYAVSKRLIIVGYTSISLIMAGTLGNSIARVTVCTNIQTASTIPFCSGKNVNIVLIVVAVLNAVADFYILVIPVHRVAKIHTLRKKKAGVLVIFLGGLIACTMSLVRLAVITENLHSTDVLWNGSRVTPFTIIEMNLGIICSCMMFIPPFFTKSKVVIYSMKSALLSRTGMSLSKARSVESQIYTGEPQSQPQANTTPQQEVLEAWEKQTPDLELLAEVEASGVVHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJM2</accession>
    <name>A0A9P4PJM2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_442698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJM2"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF261">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="721" mass="78733" checksum="F8FC6CF664A804BE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJV1</accession>
    <name>A0A9P4PJV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Utp21-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_454470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJV1"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="67"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="621"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="840"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="871"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2444628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1048" mass="113505" checksum="D0DD7A253FA0B0EF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK59</accession>
    <name>A0A9P4PK59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_520061</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK59"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000019">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="17">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="18">
        <location>
            <begin position="111"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="238"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2446574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="691" mass="77399" checksum="774C7091C1FBC3F3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKR9</accession>
    <name>A0A9P4PKR9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_431368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKR9"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="221" mass="23682" checksum="2999C5A20F9BA9F7" modified="2023-09-13" version="1">MLEIACFNVSSAIAAAEAGADRIELCADYAAGGVTPSVDALIEVRRSTTIPINVMIRPRPGDFVYTTLQHYQMKLDILNSKPTASGFVFGILDSENRVDEARNRELVDMAAGLPCTFHRAFDMVPEQAEAVESLIRCGFTSILTSGGQVDAVSGAGCVAQLQKDFGDRITFILGGGVRSSNLAALRQQTTVPWYHSAAITQPGETVDPDEVSNLQSILKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKU0</accession>
    <name>A0A9P4PKU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_281985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKU0"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040411069" description="DJ-1/PfpI domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25857" checksum="488BD7C9FF03E539" modified="2023-09-13" version="1">MYLNKLLCKALGALTVFAINIPAQSTTNSTQKPLRVGVLYENVQLSNLSGLDVLGFQTPEIVAVKVQINPDFEPLLKYTTPMDFLYISSLNATTITHSMYVEPTHTYGNAPVDLDILLIGGPDSEAVKEESLEYMRQASKNTKMILTTCSDAMWLAKGGVLDGKKATTNRVTLGSAGTKWLKVDWLDQRWVIEDGLFGGAQSWTAGGAGRAKFFYVNLMVTKLTTAGIDIRRSLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKW4</accession>
    <name>A0A9P4PKW4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SRF-TF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_355271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKW4"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="223" mass="24450" checksum="A8815C53D38F1428" modified="2023-09-13" version="1">MASEITDHDQNASPSVHDDLTNNGALIQGDANRGTKRPRPAQDDDDDDDDKPGRERRKIEIKFIQDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKPEGKNLIQACLNAPEPSTDNSNGVDDGPVDSPEDSHAQVPAGQPRGMAPSGGMPAAYMTPEAALHYQQYLQQQQPSTQYPGMPQGGMPRHPAQHYPQDQKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL43</accession>
    <name>A0A9P4PL43_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_514609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL43"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2445273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="492" mass="53153" checksum="F8ECE526FEEAF1E3" modified="2023-09-13" version="1">MEKALVTDGTMEPSDSSASCSPEAPHRPERTPKEEREQSIRGIRWFLICTAIFSANFLYGLDTTIVADIQAPISATFQNVAQLEWLGIGFTLGSAVLILPLGKAFGTFDNKRVFIACLLNFAVASALCGAAPNMDAMIVKRVWAGAGGAGMYLGSKEQALYVGVTGFVYGSGCIIGSVVGGLLADSSATRRWAFYLNLVIFGAISPIYVLLLPSVPKKPDLTIWEKTKTMDWLDILLCAGMFSCFTIAFTFSGILWEYNNGRTITLIVVFAMCAVAFAITQYYSIPTTETNRLGAALFVSIYYIPLYYLFVDGDTGTEAAVRLLPYICCYIISVLICGGFMAKTHTSNASISGYTVLLGLGMTCSQAPYAVDHVLVPSRRASELIQYINISQGSSQLIGLAIASAIFQGLAFDGMQMVLGPGYTDKEIRGAITGARSEVLERTTPQIRAISNIWLMATAAGALWTVCSLFLHRARFLTPKKESDEAQTTVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLJ1</accession>
    <name>A0A9P4PLJ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_430221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLJ1"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="474" mass="51672" checksum="E94FA1DA746C8B9C" modified="2023-09-13" version="1">MALSARTASRALRAVKPSVARPFASVQACSYSSSSEPDLKETFKKVLPAKRELLKKVKAHADKELGVVKVENTLGGMRGLKAMVWEGSVLDANEGIRFHGKTIKDCQKELPKGTSGTEMLPEAMFWLLLTGEVPSVSQTRVLSRELAEKAGIPKFVEKMLDDFPKDLHPMTQFACAVSALNYESKFAKAYANGINKADYWEPTFDDCISLLAKLPTIAAKIYQNAYRGGGALPAEIDLNQDWAYNFAAMLGKSGKENEGFQDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLQGLAGPLHGLAAQEVLRFILDMQKTVGTSFTEGEVKDFLWSVLKSGRVIPGYGHAVLRKPDPRFEALMDFANARPDIANNPVYQLVKKNSEVAPGVLTEHGKTKNPYPNVDSSSGVLFYHYGFHETLYYTATFGVSRGLGPLAQLVWDRALGLPIERPKSINLAGILKQVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLR7</accession>
    <name>A0A9P4PLR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_225135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLR7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="191" mass="21091" checksum="E266DF80F3E6AA54" modified="2023-09-13" version="1">MVLVLAWPRARDRPCNPLRPKHDMHLELSAAVAWGSSQRDNRVNSRDLQCSGAVRCLAAAGQPLSEDPPTAVCKPRLDSRVPSPNTLPFPPASRPTCMVESKPISVPTNNPLFVIAWGWVGAVAEKTTCLWWRGRSVGVLRCVSDNQPVSSFSASGFLPPSRQLGPRFFLTWGRRKRSPSWQPDIAFGRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM19</accession>
    <name>A0A9P4PM19_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_462112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM19"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040170992" evidence="3">
        <location>
            <begin position="27"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="370" mass="41502" checksum="E3EBF5F641103A9C" modified="2023-09-13" version="1">MRMFHAVAAVQLLAARLMHLATDTLAQNEAVTKRAPKGCSLSNTAVRKDWEYMSNTERKAYISAVQCLQKLPSKSDPTWAPAAKTRYDDFVAIHVNQTMYIHSNGLFLTWDRYFVWAYEQALRNECGYKGYQPYWNWFAHTDNIYKSPVFDGSDTSLGGDGEFFSHNGSLAGARTIVIPSGQGGRCIKSGPFKNTQANIGPISPGMQGFTDLVPDITVQNHRCVRRDLSTYIPKKWFTTANLLNVTIGAGSTTHKLFWTEIQGRYPDGFLGMHTSGHYTMGSDATDLYSSVNDPAFWLHHAMLDRTYWIWQTLYPSEANKVAGTLTLQNRPPTRDATVDEPLDLGVNGDTRLIKDMFDTFGGTPLCYIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMJ4</accession>
    <name>A0A9P4PMJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_383562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMJ4"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="290" mass="32212" checksum="18B79597256F259F" modified="2023-09-13" version="1">MADQKRYALITGCTPGGIGHYLALEFAAKGFHVLATVRNPSKYTPPNDQITYLPLELPGDESISSLRDRVAEITGGRLDVLYNNAGRNYTVAATDIDMREVQETFDANVFSVMRLCQIFTPLLIEAKGTIVQTGSLAGVMPYVFASVYAASKAALHAYSDTLRVELAPLGVRVITIVTGGVKSNIARTHRELPKGSYYVPIADQYEKRLTLSQQMGMDTQQYARSCVSHVIGGESWLGAVTKRWVWEGKMSWVVWFGWSYLPRGVLDWYFKSKFQLGRLTGTVGPDKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMY4</accession>
    <name>A0A9P4PMY4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMY4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="237" mass="26156" checksum="CBA6D96225C5863F" modified="2023-09-13" version="1">MASGHHHDQTAFANGSDAAAVVPPQSLLAAIRDSIKANAIRGYNVFINILFVLAILSTILANLLKATPTFIKTIPTLLYTAWVMFRTCPFPGHFSMGCALAVYIYAFITDPYLFGTPKEWLVGAFGLTCYCSLTCLCITMLNAYAPKIRAAVEKAIEEDDHLRETLKAVNWKDARTEKRSDPAIPQFGRAAYIEEEKGGNATPVIGPDANAERPAHIEQMRRFDTMPKFGHAAYIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNI9</accession>
    <name>A0A9P4PNI9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="12" type="ORF">P171DRAFT_353255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNI9"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
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    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="220"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="67"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="402"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="441"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="547"/>
            <end position="548"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="553"/>
            <end position="557"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2448390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="628" mass="71169" checksum="AB8F37A632D6B9FA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP10</accession>
    <name>A0A9P4PP10_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_441999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP10"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11395">
        <property type="entry name" value="bHLHzip_SREBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="178"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="264" mass="28752" checksum="46F1BFF83EA52A77" modified="2023-09-13" version="1">MDYIDYSSFPMLASSDCSPTTETFSFPTAFDKGFTTGPFTGPDTSLAAFDEYFGRPVSPASALENLDATPSAAPPATQPKPLSHPFTQLDALPPDFPWTTHRPVALDLNPLPPSTDSQTPSLCDSLDAPQNPTTLTSPPPSTPLTFENPAPPNPPKRRRGRPRLDRSSSSSSRTTQRTHRLPHNQVERKYRDGLNATLERLRQRVPALCASAPHGPGSGQGRPSKAMILSGAIEYIVAMERERDAWRGEVERLRRLLRAGGPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP59</accession>
    <name>A0A9P4PP59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_429239</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP59"/>
    <dbReference type="OrthoDB" id="5295093at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="13">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="12">
        <location>
            <begin position="296"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2447617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="485" mass="52341" checksum="C776684C0D338889" modified="2023-09-13" version="1">MSAKSILEADGKAIINYHLTRAPVIKPTPLPASATHNPPSKLASLHFAADADVKGVLDQAEATYPWLLASGAKFVAKPDQLIKRRGKSGLLALNKTWAEARAWIEERAGKVQRVETVDGVLRQFLVEPFVPHPQNTEYYININSVREGDWILFTHEGGVDVGDVDEKAEKLLIPVDLKNYPSNETIASTLLSKVPKGVHNVLVDFISRLYAVYVDCQFTYLEINPLVVIPNADATSAEVHFLDLAGKIDQTAEFECGAKWAIARSATALGIPAAPKDGKTTVDVGPPLEFPAPFGREMSKEEAYIAEMDAKTGASLKLTILNGSGRVWTLVAGGGASVVYADAIASAGFAGELANYGEYSGAPTETQTFHYARTVLDLMLRAPQHKDGKVLFIGGGIANFTNVASTFKGVIRALREVAPSLVEHNVQIWIRRAGPNYQEGLKNIKNVGQELGLNMHVFGPEMHVSGIVPLALVPGKTTDIPEFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP82</accession>
    <name>A0A9P4PP82_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP82"/>
    <dbReference type="OrthoDB" id="5377039at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="140" mass="14641" checksum="827284B1EAD9C8EC" modified="2023-09-13" version="1">MHSSPELDAADDDDLFPGHGDGDAPSTPRNAASFALGPASELSPPNSQGRLPEESFSALAVANAAPAGGAGDRKSGPVQTDSATGYQWSSADEAPGYEWKSNRAREEEARALEAVVDKGSMIKTRYGDPLKPSVPMTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP86</accession>
    <name>A0A9P4PP86_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_518732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP86"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040514097" evidence="5">
        <location>
            <begin position="23"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="7">
        <location>
            <begin position="180"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2447662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="330" mass="34669" checksum="46940B56CDDCCED9" modified="2023-09-13" version="1">MSSTNPPRLGWFGLGSMGLAMACNLQEQLTKQNLPALHFANRSLSKGDTLKELGGIPCQDISELVQACDVIFISVTNDEVLTSVINQFTSTNSLGGKILVDTTTVHPNTTASLATKLASHNCSFIAAPVFGPPLTARAGQLLIAVAGPPQVIEIITPYLQGVIARGVIRVGEDPSKALLLKSTSNFIGAGLMYLLSEAHVLAEKAGLPASVLESLIEANFGAYAANTSKRLTSGSYMPAAGQAPNSALELAIKDVGIGLGIANEQGVRLEVGELSMGAMEEARAFGEEKGRKLDSHSVFGVVRKKAGLRFENEAVKKRDGLTEHDEGGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPM4</accession>
    <name>A0A9P4PPM4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_483129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPM4"/>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22391" checksum="E7804AEACF155959" modified="2023-09-13" version="1">MPSSKGKPTDPKLREKVKDEVKNETNKDGGGKGQWSAWKASKLSKEYEKRGGDYENEAGTKNEPKKGAPQPKSGGKKQKEDKKAKVDEDEDEDDGGDSPSPSDKEEVEEDAQEDVQEEDAEDEDAEEEDEKPKANTAKKAKPAKSAAAKKTGGRPKKDGSEKKEAVSKKKEEKKPAEGTRKSERNAGKRKDYGEEGGEKKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ08</accession>
    <name>A0A9P4PQ08_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_404258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ08"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="326" mass="35127" checksum="DCC2FBF5BC7CF852" modified="2023-09-13" version="1">MSTTKNILITGGAGFLGPMLAAKLLKEGSYSVTLTDLQKPPQPNGVTSTTNLSLVAADLTSSADISRLISLQPTWHAIFIFHGIMSVGCEENPALSTKVNLNATQALLAAVSSLPQKPRVVYASTQAVYGPPYTATGPITDDTPATPVGVYGTHKLIMEAHINDLHRRGLVDAFAVRLPTITVRPGAPSRSAAAFLSGILREPLAGLECVIPIDDRAARQVICSPRVMIENFVRVMNAPSDAMPSHIRAIYMPGISVTLGEMYEAFEEVCGKEKLALLRTERDAEAERLLNSWPQTAEFGNAKRMGLVFDESCTQIYREYADSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQI6</accession>
    <name>A0A9P4PQI6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding module family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_483217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQI6"/>
    <dbReference type="OrthoDB" id="70316at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040379916" evidence="2">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="3">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2447164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="239" mass="25373" checksum="DAA29E6974047F18" modified="2023-09-13" version="1">MYPFTAAVLVVLCGTASAIVGDWQQCGGTSYAGDTHCATGSGCVVINQYYSQCQPGAVPVDPVPETPTTPETPVATGTPAGTGPGKTLQSGYYWIRAVAAPNYHKYMQTKPLYAPGTALLGDYTTAGQFQVQDGQLVQLVSAPGEAVKQLYATVSKTRSINNASLAVSFTAEKNAYGTFKFGGDDLQWSGPDVTRPNPSAWFVCTGQQMYINLGNYAYQTPSGCADQTIHYYNDKTANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQT2</accession>
    <name>A0A9P4PQT2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQT2"/>
    <dbReference type="OrthoDB" id="2394218at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="691" mass="76843" checksum="D99AD74EE796EA72" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQU3</accession>
    <name>A0A9P4PQU3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_518020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQU3"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="392" mass="42430" checksum="B9611D561499482B" modified="2023-09-13" version="1">MADISPPSISTWVVLAARVLLAVILRLLTTPIRWLNGSGAATFFEDIFFTIFRTALRHSSFAVSRAIFKPTTEVYEELCRKTGREARSLLVDGKGGEGVKAHWIGDEEAEVVVLYLHGGGYTQPASPDHLTYLDGLAKDMNIGAGGASSISFLVLAYSLAPDQAVYPTQLRQAAATFNQLVNVRGRSPSSIILAGDSAGGALVLALLSHILHPKAGVPRVELQVPLRGAMLFSPWVSFSTAFDSYTRNAESDTLSASFLKKWATMYLGEMDAGSERQVTWDVKSNDVYAEAYLADPRWWGGLNQVVGSMLVWVGGKELLHDAVTEFASKLKKGWKSRGGLEDGIIVVEGRDEAHIGPILNVSLGNKGKRGSQVAIEAWLLERLNAVSNKSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQU5</accession>
    <name>A0A9P4PQU5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sde2 N-terminal ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_430126</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQU5"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sde2 ubiquitin" evidence="10">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="11">
        <location>
            <begin position="103"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2447221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31565" checksum="6E68ED66D3F5C695" modified="2023-09-13" version="1">MAQAAALAGHHCVPAFNANGDAPVTVLVNTVRGTIAFTAAKDAPLSSIYETLYERAPWIANTSYILTTHSRRTVPTTDGPVSSLLSSASDTFISLRLSVPLCGGKGGFGSILRAQGGRMSSRKKKQGDVNGSSRNLDGRRLRTVAEAKTLAEYLAIKPEMDKREKEERRKRWEDIVASTERKQDELASGRTQVRLDGKWVEDKEEAENKTREAIEKMLMAQQRSSSEEEEEEEEQVAESSKPAAQRTMFGWDDEDDEFMSDSEEEEDISEEDKPKFEGKGKGKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQW8</accession>
    <name>A0A9P4PQW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_355544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQW8"/>
    <dbReference type="OrthoDB" id="4708870at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="418" mass="48027" checksum="953B4A7C8168BCC6" modified="2023-09-13" version="1">MGGHAFRGLSCPRMSPEVYLKIREQTTNILRSLFAHVVVPTEMPEKPDYGDVDFLVSGFLLEPPDSPLNWQRMVSTTRDALNTPHGRQGHLNPDVMYFAIPHPNGEHWIQIDVKVCATPDEETFAWMQFQLLYASGLKMLGSLVKPLGLTISPAGLHIRVEEMESTNFPGSLVFVTMEPGDVLKILGLDRRFLRAGFDTVEEICEYFTGTWVFNPAHYAARLEEGKYRDHLEDRSGPWVAFVTEWLPQRYPGYRLPDQDIPLHEWRKQVRIAVREKVFTMFPHITPEYYAKRAAHLKEVEEQRLQQLLTVSIPVGQDGWSDSIPEPTVVVQDAAPATPPRKPTIQAQWDTAQARVNYVGMWRRRFEKEDAKRERERVEKEKAENEKVEKDKEGVEKVEVEVEARRAKILERLAAINGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRY3</accession>
    <name>A0A9P4PRY3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_354022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRY3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475">
        <property type="entry name" value="ZYGOTE-SPECIFIC CLASS V COPY B GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475:SF1">
        <property type="entry name" value="ZYGOTE-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040417153" description="Cysteine-rich protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="7932" checksum="9100557B6192CAA9" modified="2023-09-13" version="1">MRFHTIAATAVVGLLVGTAAAGPIGYGICQTGCAAIVVACYSAAGFTFGTVLAAAAPPAILACNSAYGTCQAACAVVLLGPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS53</accession>
    <name>A0A9P4PS53_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_517893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS53"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="84"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="424" mass="47035" checksum="B30F105A994A82FE" modified="2023-09-13" version="1">MLSRTIRRSIASPLRRNAFVPAVARPAFRTVTTDAASSHAEAVPKEDDKPFEVRLSDESFETYELDPPAYTLDTTKAELKQMYYDMVAVRRMEMAADRLYKEKKIRGFCHLSTGQEAVAVGIEHAIDRADHLITAYRCHGFAMMRGGTVKSIIGELLGRREGIAYGKGGSMHMFAPGFYGGNGIVGAQVPVGAGIAFAEAYENKKTVTLALYGDGASNQGQVFEAYNMAKLWNLPIIFACENNKYGMGTAANRSSAITDYYKRGQYIPGLKINGMDVLAVKAATKFGKEWCAAGKGPLVYEFVTYRYGGHSMSDPGTTYRTREEIQRMRSTNDPIAGLKQKLLDWSVVTEEELKTIDKEARANVDAEVAEAEKMAVPDAIPKVLFEDIYVRGSEPEFLRGRIPEENFYYSETDMGKEKEATART</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSP1</accession>
    <name>A0A9P4PSP1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_405147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSP1"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="544" mass="59010" checksum="C363A4F0A7D056D9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTG9</accession>
    <name>A0A9P4PTG9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_348324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTG9"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="101"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2451059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="148" mass="16387" checksum="70B3C095426AED52" modified="2023-09-13" version="1">MGDILTQIQDELDMLLNQMQASFAYIRNRAPPAPIPGQPTLTSMQEFEASNMAAANPSAPPPLPSQDEFLKDIAELSRDMVLKEQQLEVLVASLPGLDKSEAEQVARMKELERELEGLEGERRRALEEKEALLRKVEGKIAKAGKMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTQ0</accession>
    <name>A0A9P4PTQ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_437959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTQ0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="221" mass="25855" checksum="63F2029C0C27B85E" modified="2023-09-13" version="1">MQSRPEDYTHHARKPEVGESRGVYILLRTDQRSRLSFETFIYCNYGRPGVGTMFAKTMKSYLNEHALRLVVDDQWFIAFFRQKTWKRFRNHTDKLLRSVKQPTYFSVKRFSKDMKEFQPVWYQNGQAQGPHSYLNETKGPVDGDVEEWYEKVRGLDVAKAIKSGLHYEKTSIPMGPNAWGRGSRVVRIEEGKQKASDAPFFEAPWLYLFEAQAISPKTDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTS4</accession>
    <name>A0A9P4PTS4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_350975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTS4"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30070" checksum="F2BE97D5AD8BCF3F" modified="2023-09-13" version="1">MGNDYFLVAGVPILLAGFALLQSVIHQLYWAEDTDNDPTALSQSTDASRRLVATIELIWIAIYCVKFCYLTQFKFYKPPYAYVVVALTRYYWAVVGLCSIGFLFTIVQPIVLCASKGQCRYVDGADTRSWENAVTVTDIVTDVLVMSIPILLVHMANHVRSYTIANFVFKSLSIFNIVVAATRLAIQYDFTVGRIRYVSVTFLLVIEATVALIMVSISGYRVVFLDFLMKWEREKTDQTTCLTVHQGRHPKATAAGGGGGGDGDGADSTNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU38</accession>
    <name>A0A9P4PU38_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_189706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU38"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="194" mass="21291" checksum="7B71F0F2883B6F03" modified="2023-09-13" version="1">MTTNKSGSRRRNPLQDSGSALLVSLLGLSNHTHVLDWTETSSHGVMFCLRSPKSSVGGTAHRSGVWVWSGRARLTPPWLVQQHQHRGTCRCVRAGPVSNKIVGVRRDSSRSVPAVGCIPSPPACHHTPWTLANHRGVFELIDEKRGRLRSRADTDVGTPGSAPAYRGVSKQEKEHRIDLSIGEHCLLSSAFLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU50</accession>
    <name>A0A9P4PU50_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU50"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="57" mass="6351" checksum="D224D2FC66C9D985" modified="2023-09-13" version="1">MYLSMQAHTPRTTSPTHQTAQSPHTPPSRILPTYCTPLRPTHHPHLIPPSHAPSQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUI8</accession>
    <name>A0A9P4PUI8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_350286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUI8"/>
    <dbReference type="OrthoDB" id="5430750at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="414" mass="48527" checksum="9572502B03E1D621" modified="2023-09-13" version="1">MIEEYPKGATPVQVDWQSDQYWRNRRLSPAQLQVHDIRLEDTGWRTDSDGMLEMREVLSSTLLPHLENRDRLASTIPFEELSTNRSEQMNLRSLANEYGWMNCLRSEDVQQNVSDPESFRKCRWIHISSKSSDYLSGCLLALSDWNEKPSQVVSALQQLEHCVYQQERFSKHGRYFAPFFQYLLDGAVDKKDLTNDPMLLSVPFLDWSVEGEPPPLRFQIDPREGYQSSRSSSHLLRSILQHFYRLEDTSDRESQQVFTKHKPWLTDRNLDLKVRRWYGHYPKSLNVDELWILVIDARHIVTFSSNQSWKSRWPPLQLSARIMEISFRGIRNAFVNSSTEQDYTATTHVITCLSGSLGMLHRSFWSDIPLCLADRYASYLGHLQFRLHRSPSTSLVMHLLQVQEELNIIIQIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVL6</accession>
    <name>A0A9P4PVL6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endo-chitosanase</fullName>
            <ecNumber evidence="10">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_315220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="10"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVL6"/>
    <dbReference type="OrthoDB" id="4756206at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF9">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2452215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="242" mass="24996" checksum="2E32421E4CB3099F" modified="2023-09-13" version="1" fragment="single">LAILLASVAACRDVPSNLKSFYESHKNVDCANPVSIQYSSGQGDADTVYCQDDASGAVFLKDTSNGYADADIDCDGAGMGTGDCGDDPSGQSMTAFKDLVQEYSGGAIDDLNTHIHNFVVLGNDNSAEEGDGGASFDPTKDADIQPLSVVAVVCGKKLVYGVWGDVNGGKLTGETSLSLAKQCFPNEGLSGNAGHGDHDVLYLAFPGEEAIAKDVNWGASTAKEFEASLATIGNKLVKKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVW8</accession>
    <name>A0A9P4PVW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_492765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVW8"/>
    <dbReference type="OrthoDB" id="3774194at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="288" mass="33309" checksum="04FCB0CA3348C6AB" modified="2023-09-13" version="1">MNHNRSTRTHGRYSTHYLIHTHYSHRPYYTNVPFFAADLERWGYRVDAYPYGAESPWLKEHFKKNERIRPFLLWAREVIKQDRQQRDGEGEQRADDDVGSVLKDFIRGLVQFDSPSYHYPNTNAHIHHLKRLGYPTPPSTPAVLTFYNSLLRPLGIQHNAPKPRMVPYPCGRLDCVILEFKADENRMKELLEAAMKFAAEARPGRFGELTDRTPLIDLDEHGTIFVRLYVTVQGEPRGHGDEENAMEELPAYVGEEEGAQGELPPSYDQIVVREPAETSRIQPHSNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWE7</accession>
    <name>A0A9P4PWE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_426851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWE7"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2450483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="270" mass="28186" checksum="8E3F355DD621DAC4" modified="2023-09-13" version="1">MSNPAQLLRGKSAAITGGVTGIGRAIALAYLAQGANIAVNHFGDAKSAEQFQTLLEEAASILGSKEEAQKRLAEVSGDVGDPETGKKLVAEVVRRWGRLDVVVSNAGICEFKEFLEITPQLWAKTHDANLTGAFNTIHAAATQMSTQSPPGGSIIGISSISALVGGAQQAHYTPTKAGVLSLIQSAACALGKHAIRCNALLPGTIKTQLNEQDLADEEKKKYMEGRIPLGRTGEPRDLAGPAVFLAADELSGYVTGAQLLVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWR6</accession>
    <name>A0A9P4PWR6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_479822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWR6"/>
    <dbReference type="OrthoDB" id="5296155at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40809" checksum="F7B1C3A60CAE282F" modified="2023-09-13" version="1">MGIWGPKKHYLNQVGFEQHQDQPKRISTSAGHRLTVILENGSFDSQTAKAHESHRDSVRKSGLSVILPDVPEDRGASAHSSGYSYNVWTENEKFAALRNNQQIAKRGGWKRLLILIAIILLLIIALGVGLGMGLKKKSESSSSTTATTTTNSDSGSSDTPASPTSTSSESSSAQPSNFPIGTYSLVTFLDTVQTNCTSNPLTWTCAPYTDYYTSVSKSQATFNWIISGSKGAYKISSTDNPFSIAFKNADLELLDEGKDKERYRFQIDQTRTISPSTNLTSDHAAVECDFVGNLQGVMYTKMAKEYPSDKDPDASTSYTTWPYALKVEQTAAGGKNVPSCYKTTSSGQQGESIGLDAEDATTMCSCLYKNWHTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PY17</accession>
    <name>A0A9P4PY17_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cutinase</fullName>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_427212</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PY17"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040238137" description="cutinase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2450941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="286" mass="29933" checksum="C786F66923C93244" modified="2023-09-13" version="1">MMSLILLLLPTLTLASPAPRSSSDTSTDMDAVIQGRASCASNAVVFARGTFDSGNLGVWVGPFLKDGLLSSFAGDVHVQGVNAEDYPANLADYVKEGGSERCADACAKTVDAYVEKCPGASVFLSGWSQGALCAHKCVNRISPTAFEQLKGLATFGDENALMDNPSTVPSGLPFKAYCNEANASPDLLCTASALSGIDLPSSISEWKASVYDHLSLLGDVATNSAQVKAAAGIPVAILGGFFGVSKDFLRDVATGNVRRWLVLPPHFVYGNNGMADQATRWMASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYS9</accession>
    <name>A0A9P4PYS9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_425841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYS9"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="21"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2451331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="448" mass="49295" checksum="5FCF43842A4A8E57" modified="2023-09-13" version="1">MAPRRYEAEKKDPAPLAKPLPFEFSKVTAQNRFLKGAMTERLSSWDPKNLEARGVPSKNLINVYRRWGEGEFGVILTGNIMVEYDHLEAAGNPIIPRGAPYEGERFENFKELATQSKKHGSLIVGQVSHPGRQVTESIQKNPISTSDVQLEGNVMGMTFAKPRAATDEDIKNVIEGFAHAAEYLEKAGYDGIQLHGAHGYLLAQFLSPTTNRRSDKYGGSLENRARIIIEIGQEVRRRTSSKFVLGIKLNSVEFQEKGFDTEEAGILCKLLEDNQFDFVELSGGTYESLAFGHKKESTKKREAFFLDFAEKITPSLTKTKTYVTGGFKSAAAMVDALSTVDGVGLARPVCLEPELPKDIINGKVHAAINQLTDDNDFGATNVAAGTQIRQLGKDQQPIDLSDEKNLEAFQKDVGTWQQGFSEDKDGSKYGYVDIDSVEAVPYGSAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6A1</accession>
    <name>A0A9P4U6A1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_421174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6A1"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="259"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="531"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2439909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="102619" checksum="8EC1E8798096D825" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6M9</accession>
    <name>A0A9P4U6M9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_476991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6M9"/>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="710" mass="78926" checksum="872487D58E6A180A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7A6</accession>
    <name>A0A9P4U7A6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_86579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7A6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="284" mass="31642" checksum="F5BA05D03C8A3C42" modified="2023-09-13" version="1">MAAARNLCSRPLARPRSAATRSRSITELIMVRLVAITGQGTPHLVHHKSDKASLRFNNILSYTLTIFGPQALDPTTSGLVVRPFSTTLIFILFDQHTNGITSSTPFLSRAQKHIALVACLPKHRQPQLLRRGPDGRHIAVNNTSWLRSRQPVLLDNDVHTTAQPRTLRIFTSLHIKEVRSPNRPAEEARLSKSSMGYNIPSRLSSMCSSDALHIHTISFPSDSGFVLDRATPLSATRSLRCYHRLADHLSTQKSYRRFGPWPLSASRYLRALSGKSATPSYPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7F6</accession>
    <name>A0A9P4U7F6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_370654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7F6"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="31"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="523" mass="56762" checksum="64FC541487D1673A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7R2</accession>
    <name>A0A9P4U7R2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_446392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7R2"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="435" mass="48269" checksum="FEDE951252147933" modified="2023-09-13" version="1">MNVSIELDHPNVTFTNGDTIYGRVVVYCPNTTIVVSKITASLTGETKSFMIDTTGLFMNHREEEKHCIVKESQVLLPNWNRGDNTRVESLKLGFGYHRFEFALKLPWFPECPTCPPNSPIFNDGIRNFGPSRLPPSMENLASGADSSYRIDVAVTTYKNMFKSTTRKSTRIAVWPSDTSPESTSGIPPQSFPSTTSAVASILAPPDTPTTLNAGNTMQLLPARSEPTRIIITAKFPQDFHISTGSARNIAMRLTTKRLNNSRHSLYLSSFQLLLFGYTDILAGSASRGQMSCWTLQSLSNLDRELPLDDDPDIECDIDPALWREKCVPETAVPTFDACNMGRRYEVEILLGLQCRHAGKTGRVSVVQLRVPVRIGSGLVSGRRLEAVEPAAAQNRLGTQRESVPRQMSSMNGFVEKEEFPAPPTYEEAMKEPSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7R3</accession>
    <name>A0A9P4U7R3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_100393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7R3"/>
    <dbReference type="OrthoDB" id="5600418at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="212" mass="24014" checksum="A097E63590DB0731" modified="2023-09-13" version="1">MFNRAPNPQSGTTSRSSFILFTTPVRLASLGPEHRTCPICLDEYIEPQDGRPDPSDTNEWALRVEMSITDEASTTCCRHLFGQWCLQKHINSREPWHNTCPICRLEWWKPPRSGYVSPKSIRGVGYGRVERRGGHSVRRGARSPRASIVRQVMKELAVDGGRAHVDMTVQKIREKMLLLFQERERAKMASMRASLNAARQSEQAHPGSGNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9H2</accession>
    <name>A0A9P4U9H2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_524172</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9H2"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="10">
        <location>
            <begin position="524"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2441218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="665" mass="74018" checksum="E3DC3A45FE48B82F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9P4</accession>
    <name>A0A9P4U9P4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_72367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9P4"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040358900" description="endo-1,3(4)-beta-glucanase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="7">
        <location>
            <begin position="30"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2441443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="316" mass="34392" checksum="E735B2EFE97F50B0" modified="2023-09-13" version="1">MHLQNALYVAFLSASLATAAYTLQDSCIGSSFQNCFNFYSGADPTNGFVRYLNQTDALSQGLYQVSGNNVLLNVDSKNAAPNGRASLRLESRKLYNRGLFILDVMHMPASTCGSWPSFWTFGPEKTWPANGEIDIIEGIHDSTRNAMSLHTSEGCTVTGTGSTGTVKTKNCHINAAGQTSNAGCAVDDKSASSFGTPLNPKFGGIYAMQWTSTGIKMWFFPRDSIPYNLYGNNPDPTLWGTPSANFAGSGCDFNKHFINHKIVIDTTFCGDWGNAVWASNPVCSKKAASCNDYVANNPSAFADSYWRINYLKVFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA82</accession>
    <name>A0A9P4UA82_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_474502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2441983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA82"/>
    <dbReference type="OrthoDB" id="3557394at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="615" mass="68761" checksum="505D3D16455ABBFC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAJ4</accession>
    <name>A0A9P4UAJ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_432596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAJ4"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="140"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="479" mass="53486" checksum="36509AD6D0E39905" modified="2023-09-13" version="1">MRKSPGAVITCLDRTSNEGISNPVGDACADQSRFSLPFLLSYTDSRFESITYAFAASGAHVETVFNEEYDPLDGTFARPSEGNHTLWTDGAILQARVDEITQALASQHQLDTGAPSTNDQFPLDTARQVFTPHTLLCYVSAYFRYFHPHFAFIHRPTFDIHHASLPLLLAVALAGSAHSPPTDDALSAPCLYSVAEEYIFRCLHDMVDMRAEVNDVVIQTLQAAVLINALLYSSTDQAIARRGLFHRFPALVTSVRSLVLLESRRTMPLYDMSWGQFIAEESKIRTAAAVFFSGGISTITFNNAVQLPVTEMVGDLPCADALFEVPSPDEFTQLLMSTTCDTAQSLSLKEWVLLYLEDSWPGREVKMLTSTDPKLLTIHIIALHSIIYAARTSLLTFSSYTTLLRATDRWKELHNLVYARNNASETQLVGFVKYSVELWWLARKLLELAHAGKEGCRYLTGTPTDSRRDLREFVESYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAQ7</accession>
    <name>A0A9P4UAQ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_431568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAQ7"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LITAF" evidence="7">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="188" mass="20524" checksum="03A84C8C208FC7E5" modified="2023-09-13" version="1">MEKQGVPMNQYPQSPDIAQQQPPTYHQDPNAQAQFPQGQMYQQPTGQQYAGSPPPQQAYATPPPQQYQGHPTPGVEQKGVQHPPNPGMPPQQHQSGTVYQNATPLLNLNRSPAPVDCPACGQRAMTATQFETGNTTHAWALGLCCIACLGCIPYMMSSMKDVQHKCGRCGVLLATWHRSGTTEQHIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAX7</accession>
    <name>A0A9P4UAX7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_486410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAX7"/>
    <dbReference type="OrthoDB" id="5362269at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040464183" evidence="2">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="201" mass="19885" checksum="CBC87F64C7FF726C" modified="2023-09-13" version="1">MKLLTYFLATAAVVLAQDTVSATGAACEPHGDHWHCPSGVPEPTTPPAESAKTGASATATAAVSTANSASAATTEATACEPHGDHWHCPSGVAEPTTPPPTTATATGEDHDHDEDEHHHEATASTCEPHGDHWHCPSGVAEPTTPPAETTGAASTTGTAPVANSVESAAATSSQFDGAAVAGGPMGSIQMAAAGILGLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC10</accession>
    <name>A0A9P4UC10_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_412555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC10"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF46">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="42"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="302" mass="32743" checksum="8AAA2DFAF17B63DC" modified="2023-09-13" version="1">MRESDSLTLEDGRVLSFATYGSPVPRTSVFYFHSFASSRKEAKIWHTAAAKLGVRLVAPDRPGLGNSSFQLGRTFLDWPKDVIALANHLKIRTFYVVGWSGGGPYTLACVKSIPKDRLAGAAVVSGLYPISLGTAGMMLGLRLMMLAGPWMNGVVSTITDVVVGKAARNPDPKVYEEALAKAIDGRPEVDKRAMLDEKNWPGFCEGTREGLRQGGRGTAMENKLNGSAWGFELTSLKVGEGEIPLTLWHGIEDINCPATMTMKAKELLPGAKLNMMKGEGHVSFAFNHQETILKELIGSMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC93</accession>
    <name>A0A9P4UC93_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_385435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC93"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="81"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="283" mass="31303" checksum="E765A97E026D72A7" modified="2023-09-13" version="1" fragment="single">MSKTKTKRARRELKRDATRKIANFQKAAAKTSQKPSAPSAPSAKKQKLNNDPKPPAATVPKPPVQASQKHEVPFGTYDHILLVGEGDFSFTKSLVTEHACANVTATSFDSDEEVRAKYPTFAQIHDELAALTPPVPFHHSIDATKLGSYKALRSAEEREGGWDTIAFMFPHTGGLSTDVNRQVRANQALLVGFFASCQSSHKGRPFLRDGGRVLVCLFEGDPYTLWNVRDLARHAGLKVVESYKFDAEDYPGYAHVRTLGTIEGGGAWKGEDRRARMYVFEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCC0</accession>
    <name>A0A9P4UCC0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_27300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCC0"/>
    <dbReference type="OrthoDB" id="3782588at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32641" checksum="5E010FD1E16389C1" modified="2023-09-13" version="1">MPIRSSGPLKRHLRSGSKSLNSGEFKLNSFRMCLDLLKGIANACSVFSGMITILIKDKKQEEHPWPLHIERHRASSGFIARSLMANFFSGWDTTTLPKPIDLTNEDPSLIKHYVGWVNTRKIATSKRPRWVSQERRSEPDYKEEMTLDMEKLALCYGLGERLEDAKYRNALLCTVRYYVAKEGIFPSDRAVAIMYEHTSKDSPARKMMVDFWAHAGDLSWLESKSVRYSVCREFFEDLLPALLRARAKPESETWPWADNADAYLITDGETQTEETCVLEGGSMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDZ2</accession>
    <name>A0A9P4UDZ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_353501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDZ2"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="62758" checksum="BA933A36BDD5E5CC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE53</accession>
    <name>A0A9P4UE53_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_429727</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE53"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040330166" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="16"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2446780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="280" mass="25924" checksum="BE5A1A9179239A72" modified="2023-09-13" version="1">MKSFAILFAAGLALAQDNLPQCGQTCVNNMIAIAQSSFGCSSGDVACFCGNQDFGFGLRDCAQEACGDDATAAKVISYGATYCSSVFSSASGSAASAVATGALSILSSAAASASSSLSSAAASVTDSAASDLSSATSSAGSAASSVASTLATLTSSIASEVSSRVSSVEASASSVASSVASELSSALSSVASSVASSVASDASSAASSVASDASSAASSVASDASSAASSGASAVESATSSAGDAASSAASSVTEAPGAAAKMTGLPIAGAAGLAAWLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE77</accession>
    <name>A0A9P4UE77_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_428651</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE77"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2448609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="147" mass="17014" checksum="BB915FDF2CD0F45D" modified="2023-09-13" version="1">MSFVRAASRVSRVGLRVPAYRASPVAWTAQRAFSQSAIRCSDHAEETFEEFTARYEKEFDKVNDVFELQRNLNNCFAYDLVPSPTVITAALRAARRVNDFPSAVRVFEGIKFKVENKNQYEEYLQELEPIREELGIPLKETLYPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE86</accession>
    <name>A0A9P4UE86_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PC4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_412223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE86"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2445957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="171" mass="18836" checksum="0E30F30BB02C1B55" modified="2023-09-13" version="1">MYAKRGRGGFRSANTTKKPFNKKRASPSDDESAPASKKAKNDAEDEPLVLALDTDDDKNPFVALKANGTRRVTVSDFKGQTLVSIREYYEDKESGQMKPGKKGISLPIDQYNALLAAAPLLETVLAEREEKTVRPKYDGEGAKPVEAKEGDKEQDAGVKAKNEDEEDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF41</accession>
    <name>A0A9P4UF41_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_442070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1489"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3015"/>
            <end position="3091"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4541"/>
            <end position="4617"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="5602"/>
            <end position="5678"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="6680"/>
            <end position="6756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="7307" mass="808804" checksum="FE84C98F2F4081F9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF51</accession>
    <name>A0A9P4UF51_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_427807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF51"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040270900" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="32"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="82770" checksum="6F88E2A839115B21" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF84</accession>
    <name>A0A9P4UF84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YL1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_318406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF84"/>
    <dbReference type="OrthoDB" id="3942062at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="649" mass="71209" checksum="B1C12D9F1712AF1F" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFA7</accession>
    <name>A0A9P4UFA7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_518950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFA7"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="496" mass="53879" checksum="BDC10A010109B70F" modified="2023-09-13" version="1">MTSIRLKTPHNGEYDQPTGLFINNEFVKGVDGKTFEVINPTDETVICSVHEATEKDVDIAVSAARKAFEGAWRKETPENRGRLLVKLADLFEQHAEDLAAVESLDNGKAISMAKGDVAASAGCLRYYGGWADKIEGKVVDTTPDTFNYIKKEPIGVCGQIIPWNFPLLMWSWKIGPAVACGNTVVLKTAEQTPLSALYAAKLIKEAGFPPGVINVVSGFGKVAGAAIASHMDVDKVAFTGSTVVGRQVMKAAAGSNLKKVTLELGGKSPNIVFEDADIDNAISWVNFGIYFNHGQCCCAGSRVYVQESIYDKFIQKFKERAEQNAVGDPFHHETFQGPQVSQLQFDRIMGYIEDGKKAGAVVETGGKRIGDKGFFIEPTIFTNVTEDMKIVQEEIFGPVCTVSKFKTKEEAIKIGNNTNYGLAAAVHTTNLNTAIEVSNALRAGTVWVNSYNTLHWQLPFGGFKQSGHGRELGEAALNNYTETKTVSIRLGDALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFH9</accession>
    <name>A0A9P4UFH9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_430169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFH9"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000181">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="51"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="423" mass="46279" checksum="673D96B743DB141F" modified="2023-09-13" version="1">MLASSRTALRQAASKQFTVKAGARCVSAWSQVPQGPPVSITEAFKADSNPEKINLGVGAYRDDKGKPFVLPSVKQAEKKIIEASLDKEYAGITGVPAFTKAALQLAYGPDSAPIKEDRVVITQSISGTGALRIGGAFLERFYPGAKTIYIPNPSWANHNAVFKDSGLKVEKYRYYNKDTIGLDFEGMLADLKSIPKGSIVLLHACAHNPTGVDPTEDQWKQIATAVKEGEHFPFFDMAYQGFASGNTDKDAFALRHFIKEGLRPVLAQSFAKNMGLYGERVGAFSVVCETAEEKKRVDSQIKILVRPLYSNPPVHGARIASEILNDPALNKQWLGEVKDMADRIITMRALLKENLEKLGSKHDWSHITSQIGMFAYTGLKPEQMEVLAKEHSVYATKDGRISVAGITSGNVKRLAESIYKVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG02</accession>
    <name>A0A9P4UG02_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_216690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG02"/>
    <dbReference type="OrthoDB" id="5330058at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="171" mass="19757" checksum="42EB0903C5944A00" modified="2023-09-13" version="1">MAHYTPPHAETMHAHPLTPPTPRTTPEHDDPAMERLSSIYYNRLLAKGLQLRGLQGEDRSTATQVYCPEVRRSYLNNNSRINHLDSVSCWRGLDFKQAEEVFTWERVFRKALEEQIADDVRKLVPTLPAVDDDRFTVTHCVDIDLENLVHAMLDFYYVGAYTSVHTSSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGA8</accession>
    <name>A0A9P4UGA8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucooligosaccharide oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_383449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGA8"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="43"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="473" mass="50930" checksum="797337EAC86E949D" modified="2023-09-13" version="1">MGNKPSAVESCLISAVGNDKGLIAAQSTIGYQLSHVKPYNLDIPVKPTAVAYPKTSEQVAAIVKCAVDNSLKVQPRGGGHSYANYGIGGEDGSIVVDLKNFQQFSMDKITWQATIGGGTLLDNVTKRLHENGKRAMAHGTCPQVGIGGHATIGGLGPSSRMWGSALDHVQEVEVVLANSSVVRASKDQNADVFWAMKGAGAGFGIITEFKVRTQAEPDQTTLYSYGIQAGSANDKATAFKKWQKLISDPDLSRKFASQFIMTELGVVVTGTFFGPQSEFDSLNISSRLPDADESVVVLDDWLGVVGHWAEDLALELAGDIQSNFYAKSLAYTKDDLIPDAGVDELFEYIDSTDKGTLAWFLIWDLEGGAINDVAPDATAYGHRDALFYHQVYAVNLFGRIDDTIRDFVTGLNKVVTDALGHDLGAYAGYVDRALGDDGASKYWGENLERLQQIKAVVDPGDVFHNPQSVRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGU9</accession>
    <name>A0A9P4UGU9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_428911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGU9"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38094" checksum="0DF631B7DB4E477F" modified="2023-09-13" version="1">MEKYSQFRDKGTAIAPFLPIPSPPANVLWTPIHALLFALRLFPVLSISLFYFLLLEILPIPTTIKKCVLWLLLAVPGVWWVDLQVDGVKRGRLSDKQAAGALPNAGDIVASSFTSPLDPLYLAGIFCPVFVRTWPGAKGVQVITLWGAICMAFSRPQLAPPAGTKLVELKQLSKRYPDSIICVFPESTTTNGRGILPLSPAILTLDPTTKIYPVNLRYTPGDITTPVPGGAATWVWKLLSKPTHQMRVRIARPLYNSTSIDTPKTEKASAVDMDMDMGYETNIWDSPHMRNGLHVGWEGKEETGQKVLDRVGEDLARLGRVKRVGLGLKEKTEFVKIWKSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHA4</accession>
    <name>A0A9P4UHA4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_493645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHA4"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40958" checksum="D88D88236C4E5594" modified="2023-09-13" version="1">MNTAATLTRAETHALSDADRTCEDANRQLGSARAHAPRDHNAADTGIFEESLRLKNTLDACEAQAKFKPSWEALALLVNCEYRLYVLNQTTPLRNNPFLSHWVEAVQRLGTPTAQRDAKTDGSILSDEISTVRVELIKALLQSRNPSQFARASPRQLHSNYVEMRQTSLFNIRSYVRMLEEEGIYERTPEPESDSPKSTASDTKLNEFQRWKLGMLSRLETEPEHAVAELTHLPLELSSLDFLTTLLQEHTLQGLNIEPAPVIADYIQHALRMMEQMGRGPGETGAAEPEVMLETGREAQTRAVKLLLLFMRSLIRKALLPLESIYFEIQEICIRYVWIREVRAFRAFVEEGHEEERDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHN4</accession>
    <name>A0A9P4UHN4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_199257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHN4"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2449753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="985" mass="108406" checksum="485AC8367C3DDDA4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHP0</accession>
    <name>A0A9P4UHP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_193443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHP0"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="747" mass="81410" checksum="D39E829F21A143FC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHU8</accession>
    <name>A0A9P4UHU8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_196796</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHU8"/>
    <dbReference type="OrthoDB" id="5413466at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044796">
        <property type="entry name" value="MLN51_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837:SF5">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="125"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="130"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="415"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="501"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2449632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="712" mass="76978" checksum="84FCC01D12D07550" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI35</accession>
    <name>A0A9P4UI35_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UI35"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="97" mass="10379" checksum="61E5E8BB2C453211" modified="2023-09-13" version="1">MSRKELLVGVVASIICRHLVTSHTEAHILLHTSLCLTQSCRVGTVPQPSSPNYEFPDSSAHDSPSPTGSVAPYLPFKAVGSTTARAVTPQQRVGRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJV6</accession>
    <name>A0A9P4UJV6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bystin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_479103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJV6"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2452093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="483" mass="53041" checksum="4FACEF561B62725A" modified="2023-09-13" version="1">MPKTPKSPAVREAQRHNPLAEEYAPSSVSLKQKPAKTRKRQDENAGDAYVDSKSSRKILELGQELADEAESESRPQRPAKANPAFDFDTRLDDGIEEAAQYDNDDDAWGDEEEEIVEEVEIDPEDLETFNKFMQTDDNPISWPGAEAQPSGGGTDLAALILQRIAEKESADPQAPQIYGGGDPEDAVELPAKVVEVYSKVGLILSRYKSGKLPKPFKILPTIGAWETLVAVTRPDQWTPNAVYAGTRLFVSSKPYVAQAFLNQVLLPAVQNNIFETHKLNVHLYNALKKALYKPSAFFKGIVFPMLVDGCTQREATIIASVVAKVSVPVLHSAAAIHRICEISASQMSSDPEAAGPANIFIRTLLEKKYALPYKVIDSLVFHFIRFRAAGASSADAMDTEGGDLGGAGKLPVIWHQCLLAFAQRYRNDITEDQREALLDLLLTRGHHTISPEVRRELLQGRGRGTVLEPQPVGMDGDDTMVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P632</accession>
    <name>A0A9P4P632_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_178478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P632"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="87" mass="10033" checksum="4801C36DBB26F275" modified="2023-09-13" version="1">MGFAITRLPILHFIYVRSTFRSRRASWKAVIARSHPKKQCSRSEHGSSFGLRLQCLLHTPWLHSVVGLLTDHANFYIYEHRSRGAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6K7</accession>
    <name>A0A9P4P6K7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_437322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6K7"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2438272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="739" mass="82378" checksum="A17BDCEB18450CAA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6P7</accession>
    <name>A0A9P4P6P7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_170845</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="1029"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1221"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="433"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="753"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1358"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1487"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1363"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1515"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2438252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1584" mass="172531" checksum="D3934CAB0A92C255" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6R9</accession>
    <name>A0A9P4P6R9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_491176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6R9"/>
    <dbReference type="OrthoDB" id="3795960at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="157"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="304" mass="31578" checksum="A9DE635022BB5FB5" modified="2023-09-13" version="1">MNVGALTTAFVPAPGCNDTIYGKVYRTGTVTSKWHSLGQTDTKSCYPSGFTTPDAYYSPGICPSAWSSACGNVESIGSMTETRVTCCPVGYICATPRGDPWDTFSCSRFYTQAPKILVPQQDANGRTIYMETTLGALEAYANQIEIRFQKADFETAASTTSSTSQTMTQTDALPTRTSGTVDNTNTAAGSGGGTGAGGGSGAGGGNGSRMTAGSWAGIGVGVAVVLVALVGLLVFLTRLRRKKGSKDAALDGELDGGMAVVHSAAEMANSTPVCEVGHREIGEVRGDMVMPDELDPKARAYQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P723</accession>
    <name>A0A9P4P723_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_179770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
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            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P723"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="87" mass="9529" checksum="F92CAD32C38D4509" modified="2023-09-13" version="1">MCAASFAWTTAFSLDSVGVKGQGARNQGSFREDRLVLAHEPTYGFVKRDGGCSNGKVHRTLPCNLQWSQIDVTLLLGSGNSWRLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7Z5</accession>
    <name>A0A9P4P7Z5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_368689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7Z5"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF194">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="452"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="555" mass="61831" checksum="98A289F282D5471C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P962</accession>
    <name>A0A9P4P962_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_489590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P962"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000190">
        <property type="entry name" value="C2H2 finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2439786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="813" mass="91248" checksum="5206FC165BDA1DF5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9N8</accession>
    <name>A0A9P4P9N8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_112971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9N8"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="558" mass="61662" checksum="593B9C21CA7B059F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9R9</accession>
    <name>A0A9P4P9R9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase family member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_396269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9R9"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF11">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE_OXIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="268"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2440101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="453" mass="51758" checksum="B9EA7B09BD3358DD" modified="2023-09-13" version="1">MAANVQIEGNPAFARIPPWVKAKLRPIAIERIQQVYDWIENECVPAERIYKAQLKEARWTTPAIVTDLRKKAKAQGLFNLFLPNHFEESPGLTNLEYSCCAEIMGRVYWGAQTLNCHAPETGNIELLAKYCTPEQKKKWLHPLMNGDFSSAYSMTEPDRASSDATQVGIKMEITDKEVIINGRKLYGNCKYNDEMQIFILMGCSDPDNKNPWNRHTTLVVPANTPGLKQVRNLSIMGYDWAPEGHGEYLYENVRVPRENIILGPGRAFEIAQGRLGPGRIHHCMRLIGQAERAYELALVRCYEPRKKPRGKFIGEFDSNIERIAEMRMTIDAMRLVVLNAADTMDLQGNKAGRYAIAQSKIMVPNALLKVIDEAMQIYGGQGLTQHTPLPEIWTYARFVRVADGPDSAHRHQVGRDEMKTAQRFRERAEKYTARYKELCQKWNLEPEEFWGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAJ6</accession>
    <name>A0A9P4PAJ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7788 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAJ6"/>
    <dbReference type="OrthoDB" id="1149618at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056690">
        <property type="entry name" value="DUF7788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="OS06G0652100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373:SF27">
        <property type="entry name" value="TROVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25043">
        <property type="entry name" value="DUF7788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7788" evidence="1">
        <location>
            <begin position="44"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="131" mass="14581" checksum="3BEF80315C3F786C" modified="2023-09-13" version="1">MVIHSGHEQGVISEAFDVTGAEEAVPANETVVRDETYVSGGEPRARRGMSTNSTAVFKDVIWPMAAANNPTQEDMVKQVSVLSNMQFDAAQHCSEHWTSSYCRIQRKYAKAGYQMPKLVFWNLAERALTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAX8</accession>
    <name>A0A9P4PAX8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_113594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAX8"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="130"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="187"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="270" mass="29727" checksum="C9ABED7F2D359962" modified="2023-09-13" version="1">MSHPSPSSYDVGYPQTPQQAAQSRKRSRAEEHLQQLDLPNPMAQQQNDPYAHAPGSIQVPPSHPGFSLQPFQHQPPQSAAAPTHHHHHLPNQGPSSSKRIRMEGAPPSPAQPHGPPNVVGHDGMPAPAPRPRGPKLKFTPEDDQLLVDLKEKKNLAWKQIADFFPGRSSGTLQVRYCTKLKAKTTVWTDEMVQKLRTAMHEYENDRWRIIASKVGSGFSPTACRDKAHELETGEVIEEDDTAYTQSQLGAAGSSDAGPSFQSNDPNPPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAZ4</accession>
    <name>A0A9P4PAZ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_524613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAZ4"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="158" mass="17513" checksum="9DBC0857D86AF18C" modified="2023-09-13" version="1">MPKGASSAFLDQLVRDAADTNTAAVPSLAEVECFAQRRPEDAESDEAVSTAAREIGRMAGRLVTQRRLFLTHRHKVSGMCSLSPRRGDEVWMVRDCAAPLILRPVSTETAESAEERYVHGFMNGQFIEERENRDTSNAANLVLSKTKPQRKYTVACEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBC0</accession>
    <name>A0A9P4PBC0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General amino-acid permease-like protein GAP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_475410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBC0"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="87"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="595" mass="65140" checksum="945E0E77863061B0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBC3</accession>
    <name>A0A9P4PBC3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High-affinity glucose transporter ght2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_488425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBC3"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="22"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="546" mass="59957" checksum="5D7529391C77A850" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBI0</accession>
    <name>A0A9P4PBI0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_434613</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBI0"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="68"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2440867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="412" mass="46322" checksum="9B5F7D857A6E91CF" modified="2023-09-13" version="1">MGMSPALSPRPNPPGSNAPFNAAKAKPLVHLLNHKTVPSPSLTSAATTPGGPDDGLAEEMNDGVKNQFIFGSRLGEGTYATVYRGHYRDDPSKLVAIKKMKKNTEWQDGINLDSLREMKYLAELHHPHVINLIAVFTTKDENINLVLEHLPRGELQDIWKDKEIAYGGADVKAWSNMICQAVWWIHENFVLHRDIKSNNILIAADNSLKLADFGLARSFANPEADMTYNVITRFYRPPELFLGSSHYGGCVDMWSVGCVIAELAVRDWFLPSETDLAHLGVITEVFGVPTEHDWPGISKLRFWKEQLENTPPKRPQPLSWWRSRMPLIGEAGIDLVRGLLTMDPVKRLSAKQALEHHYWSATPRPQKRENLPRKGGKEAERAMGEQLKRVGPEADEEKMAKIARKLDFGAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCZ9</accession>
    <name>A0A9P4PCZ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_488273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCZ9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="165" mass="19857" checksum="B17A1D8B1BB79C1F" modified="2023-09-13" version="1">MIYHHAWDHCALRYQRDCFSRPVLQISVQVDYSEPEPTYTPELEQSHFPMWYRANARLRHEALEQFYHCAEFTVTFPDEWFFDLHHPAPVYRWYPEIMGPEIPDIQRAQNLLLKSVRVHYPWLINLGEPRNSNQLSSTLRLLRSLHALRNLQIQFRGPNYLLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD16</accession>
    <name>A0A9P4PD16_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_367317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD16"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="319" mass="37457" checksum="9CF572C129293DA4" modified="2023-09-13" version="1">MNKKAGPSVHARPRVTVKKRVGFLNLAGEIRNQIYEYYFQQGFKCEFAEKDAKLGHKRRDCLKFFSGKLRSDDVYPICERNFTPVTTVRFSRVLGRYKRIQGLDTGWKTSLTGLIFVCKQVYTECICFFYLNTTFAFDSPNRIVNFLKVPSVTNLANVTKIQLHYHTYSDPKRSEDIRWKGKHLESWSRTCKTAARKLVNLQHIDIWVHTRETNVRLGIDEPYLKPISWFRKRRDPSKTIAKALRTANVHIVTIWNRRGAFTDMRLQLASQHLHNLFEEAISCMILGATPEVAMEDFNYAWENQYTQWHHHLQFASTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD72</accession>
    <name>A0A9P4PD72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoenolpyruvate/pyruvate domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_456938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD72"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="63"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="235" mass="25023" checksum="76C83A6B6914EBCC" modified="2023-09-13" version="1">MHAQEHPQRRKYTSFGLWQTLPGANVSRTLARAGVDWVLVDCEHGNIDAIAACGVSPIAPPGALDAEAHGILIPLLRTADEAKAIVSAAKFPPLGRRGLGSPFAMESFSPVSTMTEYLQQANDSLLTMMQIETQEAVDNIDKIAAVPAFISCHPILNGVMKPELEQALDKVLEATHKAGEKAGFFASSSEQAKKYAEKGFDMVSAALDTTLLQASLATSLSIARGVALSTSGERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDG8</accession>
    <name>A0A9P4PDG8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_488618</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDG8"/>
    <dbReference type="OrthoDB" id="3771286at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="45"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2441044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="346" mass="38358" checksum="410628FEE85C595D" modified="2023-09-13" version="1">MSAMGSFGQGQDLSSSWAKIDRIRTQQEIVTSVLLVFMVTFLANRVYVKLWLVQQCRWDDGTLLMAVIGTLILYSTTLWISTRGNLDTDLHGNSIFKALEDDAFVTPAFVLLTVLPVTYGFLKATFFILYLQLFYQLRWMRVSAAVGLSVSVAAYTAFTVATLYLSVMRKIMVYGMVAIPISAFGLASDITILLLPIIAVANLNVSRRKKLGAVLIFLSGLLACICSVVALYFRTRKGTTENVVYLLFATNIAITCELMIGVMCACMPSLAYTYRNVQAFQGVRHRLSALIPPFVLRPRPATFPTIGHIVSDEDLRPVLWKSSSLSTKSVEDIELGDQHQQGAFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEI5</accession>
    <name>A0A9P4PEI5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta,beta-carotene 9',10'-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_390466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEI5"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2442666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="533" mass="59585" checksum="41882FCD7191E8F8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF26</accession>
    <name>A0A9P4PF26_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_79106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF26"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="194" mass="20904" checksum="8105D690547BB6AA" modified="2023-09-13" version="1">MPPSNTDPFDSVLTLEDDLYTTAYAQGAADGSRAGRIEGRIFGLEKGFEKFTALGQLHGRAAVWGARLPATRPSPKTSDPSVEKESEAAEQPALKGLGGNERLRKHIQMLHGLTDPLTFSTLNTEEAVADFDDRFKRAGAKAKIIERIVGEAGNSASPERDAPETAKGNVRVSGQKQKKGDDSMEDFVGSRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFC5</accession>
    <name>A0A9P4PFC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_496892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFC5"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="377" mass="41083" checksum="C9F31D89BFDE2A6F" modified="2023-09-13" version="1">MNEADNGSPTGTRPRLVRAHAAVFKQVPAPVAYPTRPHLHREVHLYNFSTFDPANSNTHAPSSHYRPTPATMPQKDSYLPYFLFFTATLASLHALICYISPRASLTPFRGPAAPTHSPLLAHIYGVLNATVAAIRAYAAYDTSNRAVYDLALGSFVGVVWLLGSEWVGGSVRAGDVVLPVVVSGVGVGWMVVARAHCGAGPCRVEVVRDAPSNEASPVPNNETTPHPSNENAPNPEDTTTPDAVQPSTLDLIHSATHALISRLRYTFNFATPTASTWRLADIYKSKPIHQALFIRSTTGAANRAPIDFGAASNAGIIMALQQKHREQRRGLVIGQVTLWKLDHHGLEFMLVRWRGEREFAWVKSFVYGNRDGVNGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGM9</accession>
    <name>A0A9P4PGM9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_487786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGM9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="260" mass="28515" checksum="C8A680105E681C09" modified="2023-09-13" version="1">MPAIQRRVRPPMTPPTIVPTGALESPPSLLGCEVLATRLAVSAAELVDTVVVDVDITSTVLDAPSVEDDAAAGRLTVSPNPYDASVVTTNAFQVYDIAIVTPEFFAGGVYDMEGNMTLAHNQRHEVRLARLQSLGSNGQLWNDSRWTPIPLTECCSQSDQHLRPDGGSILAVENPEEAEGHQRSVVSLHFLSEPFNWNYSYSWSPSPYIGCFGNVESSTACFSLKVPGRCRLQIHVWFILTTAILNATKLVCLLWTFREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGU2</accession>
    <name>A0A9P4PGU2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_284194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGU2"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="618" mass="68668" checksum="DB0A947F0A125572" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGZ9</accession>
    <name>A0A9P4PGZ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_432966</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGZ9"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="181"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2443792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="512" mass="55270" checksum="79A2311B4739F194" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH26</accession>
    <name>A0A9P4PH26_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_455644</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH26"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2443837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="181" mass="20421" checksum="44E631895A4A8882" modified="2023-09-13" version="1">MLASSVVRASRSSMVPATRQAIRAAPAVCLQTRQAHAISNPTLANIEKRWEDMPPQEQADLWMSLRDRMKVDWKEMTLQEKKAAYYVAFGPHGPRRPPPPDEGRKVFFLAAGVIAAAVGVFSITRLFANPVRPRTMTKEWQEATEEYMKAQGTEPITFKPGMMVQSKSEKHLPAREKLNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH76</accession>
    <name>A0A9P4PH76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_362838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH76"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2443118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="338" mass="36455" checksum="147B2E3A32078F2F" modified="2023-09-13" version="1">MPEFREMAKVTLFGSGNKGGATFTPAKDIPSLAGKVVLITGAAGDLGRQTAVELAKYGRPARIYVADLPRGEAEKKAVVERITREAYESDEKDKDTTAPKTDVRFIDLDLTSFESVRACAAEFAAQEERLDILVLNAGIIRVAKGATKEGYEVHFGLNYLGHVLLAKLLVPTLEKTAAQGAEPRVVVVSSEGHAMAPKGGIQFDNLKTECAAMDYSQRYGQSKLALIHLTRHLSVHHPTLKIAAVHPGRILTGMADALKKESLLVKLTAPIAPFFCVPVSVGIVNHLWAATSKDVVSGKYYEPVGVTGKESALARDEALGRRLAEWTEEQIRGVEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHP4</accession>
    <name>A0A9P4PHP4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_28232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHP4"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001856">
        <property type="entry name" value="RAS small monomeric GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="226" mass="25325" checksum="7EE58D4AB7BBF831" modified="2023-09-13" version="1">MDPDNRITITVCGDGGCGKSSITLRLVRSEWTHDYDPTIEDSYSVTRSVDGQSYFLMLTDTAGQEEYRSLWAASNLRSDAFLLVYDITNQHSLDGLEYFVEMIDMEEENRIDQGKVPPVKLVAGNKCDLSSGRVIKAAEGLEWARKRRCGFMETSAREMVNIEETFALLVRRVVEARRLAASGGITAMHTEGTAALPPFNEKDGSPSSPNEGNEPKESFWKKLRCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI81</accession>
    <name>A0A9P4PI81_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_521754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI81"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6145" checksum="2F68BE6BFC46B549" modified="2023-09-13" version="1">MSRKVALVTGGASGMGLEVATRVSKPSTRDIHILGSPGASVAFSLSATFHPSDVTDESGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIQ1</accession>
    <name>A0A9P4PIQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_41298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIQ1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="158" mass="17322" checksum="397E1B7DDB8EAD49" modified="2023-09-13" version="1">MQVQTALRTRCLSSAQLSRGIKVALLPQYSLGTRGRCCRLTRSPIALLPSCPLALLPSRSQRLHSHLLHVCISSFLLAMELCECPLPVSLPQRLLYPHARLHHAVRSHDSLPHGYSGDVQFHQPSIQSNSNQLAFCQYARVSSVVVAFASNAVETGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ37</accession>
    <name>A0A9P4PJ37_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TOM core complex subunit Tom6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_485064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ37"/>
    <dbReference type="OrthoDB" id="5403997at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020266">
        <property type="entry name" value="Tom6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17112">
        <property type="entry name" value="Tom6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="5965" checksum="5392DE144A555628" modified="2023-09-13" version="1">MAPKAVNGRKGEPNFAVGAYQTLLSKDNRSVVTAIGMFAIGVTFLHSSWAEMLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ55</accession>
    <name>A0A9P4PJ55_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_387626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ55"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="82"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="716"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="880"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2444962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1072" mass="117271" checksum="FDFCA09305C7211D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ78</accession>
    <name>A0A9P4PJ78_9PLEO</name>
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        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2445171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ78"/>
    <dbReference type="OrthoDB" id="5386574at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <end position="497"/>
        </location>
    </feature>
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            <end position="509"/>
        </location>
    </feature>
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    </feature>
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        <location>
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            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="832"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="883"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="935"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1016" mass="109764" checksum="D5BF33917B6EE045" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKI0</accession>
    <name>A0A9P4PKI0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_357773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKI0"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="39"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="493"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2445861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="525" mass="57128" checksum="6991CEF26CFDC082" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKM9</accession>
    <name>A0A9P4PKM9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_431311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKM9"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="413" mass="45443" checksum="BBF44BD2B91E6967" modified="2023-09-13" version="1">MAHPSLTGIPFELRERIFEYLLSHTPTPSPTPAPASPLCALLTLNRQIHAEIIAFLRSQLLVLIKTNDEEFIGKSLDATWGPTPMLFLSQLRSRDLSIQKSAANAPIAMELEFYMFMSDKDATSTAAFLVPARELATVVDAQKSPSFYIWTMQALLSVKFLDSFSHAQDEAEKLLLNPYTSGFLLPVFAGVSTAGVSPSTTSLLREKLKGDYKAGAHLQKLQSLLNCAVDGAEDDWEAAAGKFGMATCYGEMVWENHEECMGAWSPFDGVHHLWIMHANVCAGLVQVLLNIAAGGPIATVPTGDKDEENAAFVEARRAAEDAIRFLSKKREWGMPETADLERAMIALRKSKAKISFRAHAACKGMGDVDAAVGYLREALKYEPETSEMLSRRIEGLKEEGARDEEDQGVVEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKN1</accession>
    <name>A0A9P4PKN1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_409036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKN1"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="884" mass="95997" checksum="442BC09D583CEFF5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKV1</accession>
    <name>A0A9P4PKV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKV1"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040210473" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="121" mass="12856" checksum="F4187EF10D96C0F7" modified="2023-09-13" version="1">MQFTATTLLALLGAASAAPARNIQARDGISITLYPEANYTGEPTVVSDVVRNKCQQVPEDVTVGSVKVSSGAFCRLTYSEPTCSLHGDVFVFLDTPAEDLTGETVTSFLCQTCTECLSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKZ7</accession>
    <name>A0A9P4PKZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_443464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKZ7"/>
    <dbReference type="OrthoDB" id="3437405at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="163" mass="18698" checksum="0B03137228D8EC1B" modified="2023-09-13" version="1">MQVSRTVAAKRMDKTWLDSGIETGLKEFEAQLKIMETWRKKIPTTPTATLTSNHNNAIQAEQAAQKELTANKKKRDQAAKTWTRKKIEDAMKQPGAYKTKKRDIGNAKTRVTRSQEKVGEATRKIPEFDERNLKKEIVNWKAIIAQLKKFETESKNIKALKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL29</accession>
    <name>A0A9P4PL29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_360060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL29"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="51"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2444884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="555" mass="61086" checksum="EE1E060F9967A2D8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL33</accession>
    <name>A0A9P4PL33_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_276301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL33"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="186"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="780" mass="89529" checksum="9869B7762FB7DAC1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLD6</accession>
    <name>A0A9P4PLD6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_483675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLD6"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="181"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="7">
        <location>
            <begin position="330"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="583"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="611" mass="68410" checksum="00BD4753BADDB66C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLH4</accession>
    <name>A0A9P4PLH4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_484018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLH4"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2445323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="341" mass="39386" checksum="8A32896821AFC922" modified="2023-09-13" version="1">MQVIREEVLNAFEREVDGHDGYREVHLGDLVELVNARLNTMWTLGDEFAHDCDFMKKAVAYSKEAKIISELAKLLPSFIIGVLGLAFKRISGNERYIQNVMLQLIQTKQHHTEKNTPSETPTILDVLLQRAPSHWETIDFLREMNVTWNTTNFVTPVLIAGVIQDLGRHQTYHPALLQEASCWDHTQSTDRLRLLDAFITESMRTQCFSSTRIHRIALCDFTFFDGYTVATGHTVGFNIRKHFNDEAHYPSATTFVAERHLEALVQATDVSVKWPFWGSQRLPCPGRFYAVHVAKLLSVSLLENWVFEIRTGQPQSMLYREYSIPHPRLKLRLKRKVNTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLZ3</accession>
    <name>A0A9P4PLZ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Swi5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_430613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLZ3"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="64788" checksum="9707C3A76A0EE620" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM80</accession>
    <name>A0A9P4PM80_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chaperone protein dnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_520591</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM80"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040399924" evidence="7">
        <location>
            <begin position="19"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="144"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2445873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="415" mass="47183" checksum="463AC3B88E678A01" modified="2023-09-13" version="1">MLLRILLLLGCLVLGVLAAEDFYKLLGVKKDASERELKKAYRSLSKKYHPDKNPGDDSAHDKFVAVAEAYEVLIDEESRRIYDQYGYEGIKQHKQGGSPRQHHDPFDLFSRFFGGSGHFHSGGQRQGPNMELRVAIPLRDFYNGRVTEFEVEKQAICSACEGTGSEDGHVETCDACGGRGARIQRQQLAPGLFQQMQVQCDKCDGKGKTIAHPCPVCGGSRVVREPEKHELHIEKGMPLGVRITYENEADESPDWVAGDLIVHLAETDPQHGQQDHERTDGTFFRRRGKDLFWREVLSLREAWMGDWTRNITHLDGHIVQLSRKRGEVVQPNQIDIIADEGMPVWHQELENSAGEVYGSLHVEYVVVLPDQMEKGMEKDFWGVWEKYRKKSGKVLDEEWGRPKEPIVMPGEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM82</accession>
    <name>A0A9P4PM82_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_230249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM82"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28590" checksum="BA937278DC304CC7" modified="2023-09-13" version="1">MSTSSPAPPVTQKPLECPVPEIFTPEQEKSLLEESNAEKVDANKGFTSGEYNSAIQGYEKALAVCPTYLEYDVAVLRSNIAACHLKLEEWKQAIESATQALEALDAIDPPASIAEKDGSGGDAGAGKVEEMDDATEVRIAALTRTGKTINDVHKLRTKALLRRAKARQQVGGWSSLQGALEDYQALSKPPHQLSSLDRKAVQAALRELPPRLDEAKNTELADMMGKLKQLGNGILKPFGLSTDNFQFAKDEASGGYSMNFNQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMM3</accession>
    <name>A0A9P4PMM3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_441800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMM3"/>
    <dbReference type="OrthoDB" id="10515105at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="244" mass="27194" checksum="2AD5EEF5720578B3" modified="2023-09-13" version="1">MSGHFSFIVSRGNNDIALETPRPLFLLIWDNHWGIFLPDRHSSSSSGKIWHKTTSSGAVVAKSTKSTTPMRLRVCSIPSPRRSSRNSRQTFVVEVIRELESRGHATREAVDFVRRQSLASVRVTTWNRERRHPLPDLALNNLGPRAPRVDFSSTDSTRGVYRGSSRGPNSSGSGSRAGSDTHRRIEEMNPNRRERNRAEVHSDVNIGHRPARATNPARATPHRGHAREVASRGTEVGMPGGWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMY3</accession>
    <name>A0A9P4PMY3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_453353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMY3"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="31"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="448" mass="48867" checksum="745B324CCB592DE3" modified="2023-09-13" version="1">MGDHTPSPTPSPSPIVYSPSQEFIGNDGQWSAFIIRVGSPAQNFRVIPSSKSSEIYVPIVDGCQTDNITSCGPLRGAYDFNGRESSGFLVNSSSTWHEIGLYEMDARPDLGFTANALYGLEILGLMLQNSGGPTLSNQVVAAVANPAVWVGMVGLGQKPANFSDFDNPQEGLIGTLRKEGKIPSRSYGYTAGAWYKRPQALASLTLGGYDQSRFDQNKVTFDFDPDDDKSLSLNVQSMVVQNTFNGSSNLLGVVNQPIYVTIDYTVPHLWLPRSVCDIFESEFHLTYDNSTDLYLVNDTVHTQLKAKNPSITIGFGKTAAPVGRVNIVLPYSAFDLQASHPIYPNATNYFPIRRALNESMYTFGRTLMQEAYLKVDYERSHFSIHQTLFPDTNAKQEIVPLLSPSDSVMEADQHSGVHISASAIAGIVIGDLALLLLLVLSCITRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ66</accession>
    <name>A0A9P4PQ66_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urease accessory protein ureG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_409106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ66"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="254" mass="27451" checksum="EC87DF1712ED48CF" modified="2023-09-13" version="1">MSHAHSHAAADHGHTHEILDGPGSFLGREMPIIEGRDWEDRSFTIGIGGPVGSGKTALMLALCKTLRTRFSIAAVTNDIFTREDCEFLTKNNALPAERIVAVETGGCPHAAVREDISTNLLTLTQLHHKFDTDLLLIESGGDNLAANYSRELADFIIYVIDVSGGDKIPRKGGPGITQSDLLIVNKCDLAEAVGADLGVMERDSRRMREGGPTIFAVIKKEEGLKNIVDLMLSAWKASGASQARKESFTPVVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQE5</accession>
    <name>A0A9P4PQE5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_243012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQE5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="194" mass="22065" checksum="C8AA35F234F60AF3" modified="2023-09-13" version="1">MIFARSRLRLPSDWDARPSSLLTFDSGSGTTPSRHLGVVPHSAPYMCAVRVRVRLDVLSQHAVADQYCLYCPVACSRHSRHLSILYICYDAVLQVPCYSCARSTMRVRYEYFDTAFPHLHTMLQSSECARARENVIRTLLPRRRTGPPARVPCLKMFTPESCGPSQGYPCCRVTQIRSWAVLQTVHLQLQLHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQV7</accession>
    <name>A0A9P4PQV7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_451796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQV7"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="107"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="751" mass="82657" checksum="F0271D355E440615" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRJ0</accession>
    <name>A0A9P4PRJ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_470887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRJ0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="201" mass="21684" checksum="D08DD826A206DD78" modified="2023-09-13" version="1">MSRTARRRQPTSAVRRARARALAGSGLVVAPSDGDRLMSSAATAAPAATTGRNRCLLSPSARCAVQGKAAGSTKRRQPASQRAVPTSGINSSTSRARIRRRRTLAAVAAADLLTTRETRACALRNNDRNADGKRGRWYTANGTNGRPFCCCTLSTTCCACRPPAPRRSRDPSATRISTSARRLRVFAEHHPHPRLLRNNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRV3</accession>
    <name>A0A9P4PRV3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_428307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRV3"/>
    <dbReference type="OrthoDB" id="3745836at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23925" checksum="10D174A0462677BE" modified="2023-09-13" version="1">MSSVLSPPTLFTPADLKSRPTLTNDITDLINDAFTRSMLPDPEKWEGAHQKRFPTRDTYFEMLGEEGVVTALFDGTRIVAVAAAVPWKGGWKKEGAGVEEGWEIKAVAVQGDEKYLHRGLAVQLYNSLEQYLIKREHSRLLKNNGKELENRTLTGHVPLWILAAECINGAYWRKRGFREARRDTCGPGTWGCLTSFEMVVLQKELTFDLVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRZ3</accession>
    <name>A0A9P4PRZ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRZ3"/>
    <dbReference type="OrthoDB" id="3784410at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="283" mass="33006" checksum="57024FBE92913F6D" modified="2023-09-13" version="1">MSAALKVFCIPKLLEPILSKLPPLDIIRYQSVNHTWHRLIADSPLLQYKAWLRADCPVPTQEVQNDDFEGAFRNWEQQVDDDAYVERAVVYNISKHLNPVLVRCFMQHMPTKLRFVYFDDYLSLNPACLRALMYWYEAHKERENVWGHMALCRPDVSAIRWGTGASDDSGIPLELEALHDEDADSSYKISLLRRGQAYKRPGEPLVLTLRDLMRSVKWQWKRWLESEMKLHDRRHGRGCDHAGGLPQERCFKFEEVSDDEERRSAVAAKKAQLLDALIEKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSE6</accession>
    <name>A0A9P4PSE6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_508211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSE6"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="305" mass="33582" checksum="C236C557CB43211C" modified="2023-09-13" version="1">MDDPKTCSMRPFRPLLPAKRGFEKPQPAPPEAPPKKRNILACDSCRGKRIKCDGARPTCDACDQRSLTCHYDERTSRHSKEDEVASKRESTVEKLLTLIEAGTEEHAVGLVRSLRAGRAIEAIVSQPEPGAEHATPHLSYDTSGLPTVAPSMRSELGQKKKETEASQAASRGGDAVLQREYDALAKRAATLQEIMDLLRSMPENDAQRLLRELRSASEVDSVLQATKASGHDQPNTEQIHTNSLPPSMHGNFELELSMLYPRAFPDTDHPHNVGLVPGLTDGMADVNIQDPWSSDPVNVWELPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSE7</accession>
    <name>A0A9P4PSE7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_195286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSE7"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040431821" description="GPI-anchor transamidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43912" checksum="1E95E2D040AA8279" modified="2023-09-13" version="1">MKLSAALAPLLLAPLAAAEHTSNWAVLVGTSRFWFNYRHLANVLSLYRTVKRLGIPDSQIILMLPDDMACNPRNAFPGTVYNNADRALDLYGDNIEVDYRGYEVTVENFIRLMTDRVSEDMPRSKRLMTDERSNILVYMTGHGGNEFLKFQDAEEISAYDLADAFGQMWEKKRYHEMLFMIDTCQANTMYSKFYSPNILATGSSDIDQSSYSHHADNDVGVAVIDRYTYYNLEFLETNVRDPTSKVTMGELFDSYNPADMHSDPGIRYDLFAGGDAGARSRLVMDFFGNVQNVEIDAGSGKDETQWREELEAIDKMILEAKRRHNETLNLRPQAQHIMEEAVAMEPQQSTKKPGAVKVDTESGWSKQIVGAAALLGFAGVWAAGSWLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSK8</accession>
    <name>A0A9P4PSK8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_379329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSK8"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="186"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="356" mass="40581" checksum="FB99F23EE0802701" modified="2023-09-13" version="1">MVLSNTYQLAVILSSFLLPIVTYFYFTQRPKRSPAGPLPPPTEITDIFIHPIKSCHYLTVKSARLLPTGLDLDRHWMWVSYPKLEFQTIRQNSKMTLIRPSYDAETDILTVVAPVPDSIDQKLQFSVPAHPSQEWLAKHTQLIYANIWGKETSAHAYSTDLTGPFNNFFGKEVRLVYKSPFFDAPRKLPSNGAEDILGRPASTCFPDLMPILVGCESSIDELNSRIRANDDITIDIHRFRPNIIVKGNQPWDEDRWKTLRILPKPGSKSATQTFVLDVTQRCARCQVPNVDPETAGKHKRQPWDTLMKYRRVDEGITYKPCFGMLCVPQGEGGMLEVGMKMEVLEVTDKHRYIPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTQ4</accession>
    <name>A0A9P4PTQ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanovirin-N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_404217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTQ4"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="108" mass="12111" checksum="0029A05211C85C87" modified="2023-09-13" version="1">MSFHYTAEEGSIRVDDNHILRARLQRADGEWQDAEIDLNHHIGNDNGSFFWDGENFSDSAQDVHFAIEGGGEVPVLRATLLNGDGEGIQRDLNLSERITNYDGTFAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTW5</accession>
    <name>A0A9P4PTW5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_2960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTW5"/>
    <dbReference type="OrthoDB" id="3775616at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40813" checksum="E6C73542EEEEE02A" modified="2023-09-13" version="1">MKRKRSPDLAVARACPKIAKHGVSRQPQDIDKTGSGPCPLLRIIQQYGLLISIVANLAPEDLFSLAATSKAIYKAIFSGEASTTNMFSKMPCAGRGVDIRRLNHIHSPTTRNPRCIRYDVCGDKMRARGARPPRIVDTLPCVKCKLTTCDECRIHCVFNSTIEPEEEPDELPTYSGFVLLSPTDMPILTPAHLNLSGEKPTVPYHDQGFLDLPWTATQPANPESIDEILDFDLGRGPLRLADDSTARHPSSVIQAFWEYTEERKLRMCDECREEQKVGEFHPQQHECACTLRERVLGQWMCVECFQKESLCTSDITKNQMAFRYPRPGVRSSRVIRCSCGKSLNGRGRHVCLWCTGLLAHEVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUE0</accession>
    <name>A0A9P4PUE0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell morphogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_375812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="343"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1452"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1749"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1966"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2416"/>
            <end position="2482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2544"/>
            <end position="2569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2451"/>
            <end position="2474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2451540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2569" mass="286654" checksum="EF41EC4BFDBE82D3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUZ6</accession>
    <name>A0A9P4PUZ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUZ6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="65" mass="7395" checksum="8033F7A8040C22F5" modified="2023-09-13" version="1">MLRNTSRQGNTRRSDYPQPMPSPMRSVQDTKRPCAKNTFIPVALETNISHKPTPIIPGPFYLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVC1</accession>
    <name>A0A9P4PVC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_350373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVC1"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="351" mass="38900" checksum="344636EFA22E2236" modified="2023-09-13" version="1">MNTLSIRAFIPPLTRRAIPLRATRCYAMQAPGAPTVEIFSQQHKWMQKERAARDVEASRSVDYLRDEVASRLCERLLDINRPFPRVLDLGANACNIARQLTFPSEDSPDKGPRGIRVGKLTAAESSEALLYRDADLPFNSEINIERQVLPTSELLPFEPDTFDAVLSSLSMHWINDLPSVLAQVNSALKPDSPFIGVMMGGDSLYELRTSLQLAEQERRGGVATHTSPLADVRDVGGLLQKAGFNLLTVDVDDIVVDFPDIFALMKDLQAMGESNAVISREKGPIQRDTLLAAEGIYRALHGNEDGSLPATFRLIYMIGWKSSPTQAKPLERGTGMFSIKDYLEKNGEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVT6</accession>
    <name>A0A9P4PVT6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_153738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVT6"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="67"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="323" mass="36125" checksum="0E5EB548C949E509" modified="2023-09-13" version="1">MSAPGESKLSQTQYYTISNFKFENGDTLPEVKLAYQILNTEHKKVAVVHTCFKGRLDGTLTHSSGAFKGHRIILIALLGNGESSSPSNTSNFPKTLEYMDCVRAEHALLTKELKIETVDAMLGFSMGGQITYHWITMYPKFVRKAIIVCSSARTSRHNFQFLEGPRAALESAKDEESGKYAFGKAYSAWLTSAEWFDDELYKAMGAHSLAAWDKAVMDSYHDWSGKDLLAMLGMWQRGDIVRCVPQAKGDLGKALQTIAAKVLLIPCETDQYFRPYVNEREKEDLNSATVAVISSIWGHIVGGDADKDATRWMDDKIQTFLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW35</accession>
    <name>A0A9P4PW35_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_440407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW35"/>
    <dbReference type="OrthoDB" id="10387973at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040161364" evidence="1">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="101" mass="11036" checksum="CD55214F591A1C70" modified="2023-09-13" version="1">MLATLALILTTAIAVHAAPHSESRDLTSFAPCEIALTNCLREEAGIRKCECNAGNAVRCSAIAIPLAQAGTEDLAFYRWERLRECPRDGNQQMCEKGRCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXD7</accession>
    <name>A0A9P4PXD7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_468399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXD7"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2452010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36265" checksum="9714450542C6C42E" modified="2023-09-13" version="1">MNEKAPPITELPEKRHVQTTFNYWDDPGDGSKPTPIVIGGGRISNKRPHLPHDFVVTDISGDEDKYTLDSHGFQYCRHESLEKDFVDEHAIQTLYYDQCRQFLKDVTGASRVHIFNHKVRRGPTQWHHLGFSNLTNRGPVTRTHVDQSYDGAELRLRWEFPKEADELVKRRYQIINVWRPIATIQKDPIATADSSSVPDSDLVAANMTEDGFKGEQWVVRHNPAHRWYYKNLLTPDEVLLIKCFDSTTWVARRSLHSAFEDAAHRDKESRQSIELVLGCASFTLLLVSPRGPDIDKLRGSDHLADSVSDLPAWRSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXS5</accession>
    <name>A0A9P4PXS5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXS5"/>
    <dbReference type="OrthoDB" id="2504266at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046784">
        <property type="entry name" value="Eap1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20566">
        <property type="entry name" value="Eap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="837" mass="91970" checksum="2851DD93543F9E87" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZJ6</accession>
    <name>A0A9P4PZJ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_478790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZJ6"/>
    <dbReference type="OrthoDB" id="2561193at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="192" mass="22053" checksum="A850420463512D9E" modified="2023-09-13" version="1">MLRNTYTAFQRHLLFFSTPTNPPRLTVLSGMRAAASLGLDFPICVLLGISLRALYAPFPHVFSPINIERIPQSEHRAQLSYAKLDKQEYCCSDLLSILPQDPRKGFLKHKIDQGHIVSFWAMSASTNTHTVSRDDVERFQRGDWGKKVAERRRGRDDVLPLWRGGPIIVSWHSWAIRRVLGVRVYEENPKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4T2</accession>
    <name>A0A9P4U4T2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_437769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4T2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="208" mass="23646" checksum="A149C4EA059C58A0" modified="2023-09-13" version="1" fragment="single">MLQRQKTPSPPPIWRKVAKEVRHETSRVTQDQSSAAKARIASTERLALNERHIPTKRPASNEHPASTKRPTPNERPKLNTDLVSRESNTYLSADGILSRFPVLVETPSYVQDHRYELPSKQEASTTSRLDTDQNEGAWLGDTQHHTISRELEEGVLNVDSTCAETTGYHSYLVFGGKELVLAISERSLALELWHLNGRRMFSRDYCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U556</accession>
    <name>A0A9P4U556_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_179969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U556"/>
    <dbReference type="OrthoDB" id="3737134at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="453" mass="49593" checksum="00C7C19852D88F81" modified="2023-09-13" version="1">MANLFRKGGIPALASSLFDHTSPCPGTLIILVNERARQATIELQFELPVRGFDSDQRISLVYDGDTFEPGTTTVSDAPASAAQLAQVARPRGGKLKSLGLVLTQPCVVLSPSPGNLCAKDAFDPRFEQLAALAKATRLDILFDYYWLHPDKTAQFECLAGSSGLTGFPRLSAETAREADWTIFSPGEAPPCSAPPLYEEESSKRPRRSPLGSPQAPRPKRLLLDTGVYVDPGSPTEKATTIAPSSPPVDPLDPLQAATEAAMAKLLPSALRDVLPEVLSDVLPGILKHMFTVPTSTPPPQATPPPNPMSPLHRAIRAQLNDCAEKVAEQIAVDNYAHALEVRETADLVLEEHLEEHRLELAVVKEDGLMEIHRVYDTKLEQLEERTRELVETVELETSEAYTTAKEKLDEYMGEQRMELVKERLSIAQRRRSGSLATEEGARRANSVPLDMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U746</accession>
    <name>A0A9P4U746_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_111994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U746"/>
    <dbReference type="OrthoDB" id="10549983at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040434755" evidence="2">
        <location>
            <begin position="17"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="261" mass="28107" checksum="8206AFA584D68730" modified="2023-09-13" version="1">MRSALIIATFALGLLAAPVPDAEIQALAPVERGSNRRSDDDEDEEIEEIDARAVRGSNRRSEEDDDELDTRAVRGSNKRFAEDEEEEIDTRAVRGSNKRAVRGSNKRDAEAEASPAVRGSNKRDAEAEPAVRGSNKRGAEAEPAVRGSNKREPAVRGSNKRDAEAEPAVRGSNKREAEAAVRGSNKREPAVRGSNKREAEAAVRGSNKREAEAAVRGSNKREAEAAVRGSNKRGTWSNGLIEALKARGFSSAALMSVRAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7D6</accession>
    <name>A0A9P4U7D6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_448569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7D6"/>
    <dbReference type="OrthoDB" id="5378435at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="39414" checksum="7FFB9D3495A3A7AD" modified="2023-09-13" version="1">MAGNMNTYAPNPYRTARSSSSQSAHPYRIEKPRSNHNSPRTVERRKTTTGAKLYATLDDHYNMMMGITGDEAVEPMGEPANTRPMSWHPSSNQYYTRPQSTMFDQSHDWPQQNYSDQTSVQGSDFYSYSSSNSMGADATHQHPTYMTGYEAHRGSQDSDSSWQTQQSQQSYFHSYSTPATEPMPWYLQEWARKNQEQAAASQNGSMEFLPIQHPTEPEEQQADASMENSGKELIGMGLYDVSDSSLDWTSPLGEATGKGLKLEETWQPPDEDEDDDDDDDASSDDGEEELPPPPAPMAPVVSAKAQPAGNMEGQSFFFDEDENISKEWWYQHLKQPSMPVRDAGYGYGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7E7</accession>
    <name>A0A9P4U7E7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_489867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7E7"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174:SF0">
        <property type="entry name" value="HD PHOSPHOHYDROLASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035170">
        <property type="entry name" value="HD_phosphohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22680" checksum="39D9E9A368EBFD4C" modified="2023-09-13" version="1">MAPPTYHIPDAIKQLYQDPARHYHNLNHVAHVLSLIPDNHAHVTELIYATWFHDSVYDPRAPHGVNERESIKLWEKHVEEQGEELKHIKDFVSLMIQCTITHSLPDEPPADEALVGLIKRFLDMDMDVLAASRVGYLEYAGQVRREYKHLSDEEFRGGRAAFLESEIRKGKVFLLEENGEKNEVALGNMEAELGMLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7I7</accession>
    <name>A0A9P4U7I7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPR1/FUN34/YaaH-class plasma membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_457685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7I7"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2439881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30427" checksum="75DE9D90F8409A3D" modified="2023-09-13" version="1">MSDSHKTDHEMKEHNGHNIVGNGVELSRQVTVQLSPEQYERLFFQPSAPRRGDLAKRFANPTLLGLIGFLIPYTSTILTLCGFQGAVAPQTLVGLSGDYYFFGCIAMNLAGIAEFILGNTFPMAVFIIYGSHWGSLAYTQDPIHQTTSAFEELGGATGAPYNSSQGFHNVTMAIASFVFFMGTFRVNVFFTLTFFGLIMLFSFIAAADFRIAHATTEADVEHINKLLHFAGGFGFIGLVCGWYLAILTACEAVGIPCPLPILDLSSKVFPKKDPNANID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7P4</accession>
    <name>A0A9P4U7P4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carnitinyl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_524414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7P4"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="283" mass="31411" checksum="E7DDB852C7BBF2E7" modified="2023-09-13" version="1">MTTPRTKNPMPDWIESPHPHVQHSLITFPAKHILQVTINRPEARNCLPVEGTIELGALWKWYDAEPELRVAVFTGAGDKAFCAGMDLKQRFDILDTGDIAHDYPPGQFAGMSNRAGKKPIIVACNGHAHGGGFEAILNADVIFASPNATFALPEVLRGVSALAGALPRVFLLFGNHRAMDLILTGRRLSVEEAHAWGLVKEIVPQEQLLEKTLEYAKLIASLSPDSVIISRLAAREAWESGVSRATMRGQELWAENMLRSENAREGLQAYKEKREPRWKRSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U801</accession>
    <name>A0A9P4U801_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_488223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U801"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000090">
        <property type="entry name" value="Lipoyltransferase and lipoate-protein ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="6">
        <location>
            <begin position="71"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2441784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="420" mass="47032" checksum="FE81EFAA70C7F242" modified="2023-09-13" version="1">MAPSRGLARLLLRPALSNTAAYLRNVSFARRAYSFAEQLASPANRVQSYISRSSDPFVNLSIEDYILRTSPPDSTVLFLYKNRPCVVIGRNQNPWSEVNLGILQAAAPRSTAVKDTEPPAIGDVHLVRRRSGGGAVFHDEGNLNWSITCPRTEFTRDKHAEMVVRALRKIGIERARVNERHDIVLDQGHEKRPSDPQDTHQTAYTVDEGGPRPLKVSGSAYKLTRGRALHHATTLLASPNLHIIPQYLHSPARKSIQAKGVESVSSPVANIGLDVEMFQKRLQDEFSAMYAHQGKPHIVQVVGEEHLQIPEIRKGYNELKTDDWMWSQTPQFDLVLEGPARSEIKINVHHGIIKTLETKGDSLPDDMLEELQTALVGQKLQDVGNWTQFLQSRIEPWHADYGVIADRLEILLPVPHLGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U804</accession>
    <name>A0A9P4U804_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_524786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U804"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF127">
        <property type="entry name" value="TYROSINASE COPPER-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="6">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2439688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="525" mass="59528" checksum="E94F512B2D4CE719" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8L8</accession>
    <name>A0A9P4U8L8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_434714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8L8"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1242" mass="134826" checksum="3E4255C2D51A009E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U936</accession>
    <name>A0A9P4U936_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_434432</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U936"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="102"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="611"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2441815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="823" mass="88722" checksum="81E55457B1B2753A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U954</accession>
    <name>A0A9P4U954_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_435491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U954"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2440722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="511" mass="57704" checksum="945CDF842E607178" modified="2023-09-13" version="1">MAATNGDSSEIAGNPPPNVIIPPKNVRDSITKTADFVHRRGERDEAALVTRVREQGKSNMAFVLPEDTYNPYYAWYLQQLREGKGPSAATARAVADAKPQGPPEPPKFRFSARMPQINAKDLEILRLTALYTARVGENWLKELRNRESGNAQFEFLRPTHSFFPFFRALVEQYKILLEEEQTVEARIEDLQRNIQNRFHVLDRAKGRAEYVKYVTHQKEKEEKKAEDEKKEYAAIDWHDFGVIATVLFDEGDDAADLPPPTNLTDLQSASLEQKAMVSLSSKRIEEALPDDVAFYNTSQQPVIPPSAYPGMPPMAPPVQPAYAPPPAAPYGYQQPAPVDWQADEARLAREQRAERDQVARAQATARGAPGTMRIRTDYVPRGKKANVTTVQCPNCKQMFPSDEIEEHMRIELLDPRWKEQRAKTEARYSTVITPNEAANNLKRFASQRDDIYDGATGVPITEEEAARRKKAATSYDGQPDLAKDAARIHQMQSMNLQDQLRRIHEKHGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9N5</accession>
    <name>A0A9P4U9N5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_415270</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9N5"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000027">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000003">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040509623" description="Mannosyl-oligosaccharide glucosidase" evidence="15">
        <location>
            <begin position="29"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="17">
        <location>
            <begin position="40"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="16">
        <location>
            <begin position="302"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2443629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="809" mass="92217" checksum="2DDC526237378B9B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAC1</accession>
    <name>A0A9P4UAC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-protein phosphatase-like protein SIW14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_434532</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAC1"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2441937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="262" mass="29346" checksum="5C9AFC1EF5E84FCA" modified="2023-09-13" version="1">MSTNKVEQPTARSSLFTSVKSYFASLGLSPNNLLTEHAECTHHEDLADGDESADVVKTRTPSPITETIAPGRLRSLFPPSNYGAVVPGSVYRSSYPQPKNFDFLQSLKLKTIITLVPEEIPEEYREFMKSAGIQHFQVHINANKGAVRVQSCDINRALNILLDRTNHPVLIHCNKGKHRTGCLVATVRRIQGLDIEAIRHEYHTYADPKARFWDEVFFEHFDINTVMWLARKENWVLPEVEGAPISPPPSPVPSLAVAKPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAV9</accession>
    <name>A0A9P4UAV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAV9"/>
    <dbReference type="OrthoDB" id="10662148at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="458" mass="50011" checksum="51302075E3B7E90E" modified="2023-09-13" version="1">MSPPSDHNTQLLTHRKSSRHSQGRRPSLQAQEPLRPTQNAYNTPAFFQDYASSSHPLGPLSPTYCPAPQSSYEPDAGTIPGTVNNMSCPGSNAPCESRAMRQTNPFRGNRKKPRAYPELQNKNLTKTPQTKYEQAMSYIDGVVRKTTDTLVVQPKDMGAAQHLPTLLHQSRTSPVQGPSKIPPQSPILQELQNREGGYFPLKPGLRGTEHRKGMPPCEPAQVPQKAWESEQSPHNKDSMSRSSDEQELVAAMQGLELFGGLRPAPDQSRVPPFSRADNQADDTDFGNAAAARTTLSEPIRQDTAFQHMPSPGREGPSNPDDAGENAAVTTENVSHEDPVSLKQPELSILQKTHQTTEELPVPSAFSVTLENAPAQLEDASGKPTLHTTSKIESESEVLSSAEDSLEDIPIDSPTPSSPTPSVQSTSSGDHFEVVTTNKYQTERNGRPGVWGRWVQGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB12</accession>
    <name>A0A9P4UB12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_445018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB12"/>
    <dbReference type="OrthoDB" id="3793694at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="735" mass="77727" checksum="B5B091475ACF4A0B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBP7</accession>
    <name>A0A9P4UBP7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_31663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBP7"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000274">
        <property type="entry name" value="ERF1 methyltransferase catalytic subunit MTQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="254" mass="27736" checksum="0C329F0C698C4EC5" modified="2023-09-13" version="1">MLPTPSTSHVCFDRVYEPAEDSFLLLDTLSSSSEAAFLQERFSNAQSTPPLVLEVGVGSGVVLAFTAANAKRILGRQDVLTIGTDINSFACQAAAQTIRTAITEHGHGKTISLDVVNGDLASCLRPQSVDVFIFNPPYVPADLPDFARHERYNGLPDGDRKTTFEQDSYLLELSYAGGEEGMVVTNRMLEQIPEILSTDRGVAYVLLCAQNKPEAVKQGIRQWGTGWMAETVGSSGKQAGWEKLQIVRIWKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBX8</accession>
    <name>A0A9P4UBX8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromosome segregation in meiosis protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_431466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBX8"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="153" mass="16987" checksum="EE4647AFBD3C695E" modified="2023-09-13" version="1">MYQFWLDELYPRAKFADGLAMIEKLGHSKRVQMMRKEWIDEGKPRHNAREDEDEDAVEVVGANEPVQRDDGPMEGVQDEITQSVEDDAPQDVARGARGPSAPPEGPDDDELDALLAGDSAPAHPTTAVNTTTNEEEDPFADAMEAMADMEDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCS0</accession>
    <name>A0A9P4UCS0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCS0"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="348" mass="39160" checksum="C74BB802442A7044" modified="2023-09-13" version="1">MQLWPSLSQAASTFQLQFFSNTSRPAFHLRILTFNIRYATDSPFTNEKPWAERVPRVLNQIQHETRFTDGTSTAPGSPPQHSAASIICLQEVLHSQLIDLLNSLNELPSSNDQLADGPIWAHVGVGRDDGHQKGEYSPILYPVIVFKLIHTETIWLSPTPEKPSLGWDAGSIRLLTIAVLEHRVTGRRILASTTHLDNEGSKSREHSVSIILDSLKRVAKDWSTEDVLPVFLAGDFNSFPTQEAYLDMAKSEYVYDLRDSVPEGRRYGEDITFTGFQKEKWSDEQGRIDFIWLGPGDAVCKHDHGVKEEVEGSCQWIVDGYTVLPNVFDDGVYLSDHRCVVGDVRLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD36</accession>
    <name>A0A9P4UD36_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_287043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD36"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="112" mass="12028" checksum="7494AD7A36C9463F" modified="2023-09-13" version="1">MPPHAPLTVGPTVFHARGPRRSWPKEAVPARPQSPGVLLVHSRRPTAPATPRRGGSLLRDCCFVSTLPRRRLCSLAQGLLCILHPEGGALEGAHRNSAIAIIDRGTHLVSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDF3</accession>
    <name>A0A9P4UDF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_432008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDF3"/>
    <dbReference type="OrthoDB" id="5190067at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="229" mass="26316" checksum="22D2A1E7B5E0E220" modified="2023-09-13" version="1">MSHDPEIRLSTGGLPPIKIHEEYLVEEALSYDSTCCYTAWVREEIVQVPEGWSASDFNIANERPQWSIQIYDTTLQAADPGHLKTLAKTFHEETRTEREVGGRGQRDRIDVWGVPFAAGASVEERIAKCKAHMLAEITARETSGDDDFHVSELHGHYQWNRAILIIDRPERSWNEDEGGFLVVYWDLHPSYLKMFTRAYAEDTQEPELSAIRYTRNELGNLLGNLRSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDW9</accession>
    <name>A0A9P4UDW9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_274674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDW9"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2445853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="722" mass="79343" checksum="46D10407261ACB56" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE99</accession>
    <name>A0A9P4UE99_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_429861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE99"/>
    <dbReference type="OrthoDB" id="3763553at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="426" mass="49585" checksum="DDBD3CDC609586E6" modified="2023-09-13" version="1">MRSCIVSSSAADERELQSSVPEIPRDLSTECFQLSTSVANFSFAYVLGFTHQHRGRLRHWHCHRSVYHRDNNPLLVADGLVDLYQEVHVATDLYAQSLNAAMEAFINPWTELKPITLSSAEYVRIASTLSILRIFYQLQLKCSTQEDIMPTSRAFLTHLDQWEIKQLAALDEFLLNVGYGRLSAVYHRLDAKYSDWKALSNQSTYVQRYFRTLKFSVTQEEPSSITPISIMQAVRPGLHGQAFQLPLPPQWAGTIAEALSRMLKEDTVSRCPSRTFGWFLYDCSMYQWDWYPCFVDLGMFFWDYRRLEDWGILHQPTYDSMLSKFKAHLEGASKRGPMPLPRLHPCAHYSEKQKVEIIVRWTRSPIQCSIEEWLWQHYAVDHYSQSPLTADHSNFNVRSFNYNIQCNEDVEKSCFNPRGCKFHSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF98</accession>
    <name>A0A9P4UF98_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF98"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="196" mass="21988" checksum="8555BE64683177AC" modified="2023-09-13" version="1">MVVPSRYVTPLGVVSAYANCVGVDTAGLELKDQDGQVDPADMGFTQGSWGYNLCYRDALHGHGCPLPADQCFRRHTDLRWHEAVHIAKTAKGRDFLINYAQSWTRRWPSKKFDSDREGRGLPIAWPFPPANMQQAEDLKHYQQWQWSILPKGRQLRELSHLPVAADRGGDAGRGGHGSRQVRLGGVELGDDPLDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFM7</accession>
    <name>A0A9P4UFM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_518182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFM7"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF10">
        <property type="entry name" value="TIP ELONGATION ABERRANT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="48253" checksum="D18CDC770F7AA380" modified="2023-09-13" version="1">MAEVAAGAGIALAAEEVLSTSLQAGVATYFLAKPTQPLNATFTRVAVVHDDEMHKRSLTRSNHTLTIVNSKAYIFGGETADATVATNDMHVVNLEPEENHEPEYQLIPAIANEEEGRVPRGRTNHAACAFEGGLVVYGGTSSTGQPADDGDVWIFNPPSKTWSILYSFATDGPVLGPETEVRIFALNTSLLLLIGNPADGISTIAKLTPSLSSDATSAPSPYETLIPPPSPTSPSNASLHNNTLYLISSTDPVSSQLHVLPLDSKDAKWTTLTFPTNPLVPGPRARHAGALLPLTTGYGRNYLVYLLGARSELASNTSNPTGAGFTEQDLSFQSTTEKEPPQEPTQWSDTWTLQLPSSALAPQATLSFKDAIKPAKIKDAIRTGVGAESGKWTWADVEVRVPDDLGGAEAGKLHPGPRAFFGADVMKDGKSVLFWGGENAEGEKVGDGWVVRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFP6</accession>
    <name>A0A9P4UFP6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_218764</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFP6"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040535366" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="401"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2448761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="457" mass="49301" checksum="EAD8643B5E1084B4" modified="2023-09-13" version="1">MKSFVALSILGAAIAPVFAAIVPRQSKGKLTPVTVRGNAFYADDERFYMRGVAYQPGGASDAKDPLLDLESLRRDVKNFKDLGINTVRIYTIDNSKNHDEGMKILDDAGIYLALDANTPKYSLNRESNETLHRSYNDVYLQSVFATIDQFADYNNLLVFFSGNEVINDVNNTNAAPYIKAVTRDMKQYISNRHSRQIPVGYSAADVAKVIEQQALYFDCGSDDARADFFAFNDYSWCDKENGLQTFTGAGWDKKVETYKNFPRPIFLSEHGCIEPNRQWGEIAALFSTKMTGVYSGGLAYEYTVEPNGYGIVDLNNGKIEPNEDFESLKAAYANVTNPSGNGGAKTTDGKASECPPESDDWPITSRALLAMPEGAKKYMDEGAGKGPGLDGDDSSHWAGEPSEATATAGSGAPTRTPTGGAAPEGGSEEGAAAGTEVPMKFVGMVVASVVLGAAMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG13</accession>
    <name>A0A9P4UG13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_510272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG13"/>
    <dbReference type="OrthoDB" id="10260355at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="331" mass="36122" checksum="0514A00690C53AD6" modified="2023-09-13" version="1">MPPRPQIVDALIIGSGPAGLAASLVYARTRTTAIVFDSQSYRNEGIAHMHSVPSRDHINPYEFRSIAREQITSRYPSVWFDNVTITQAVKKLLGKEKYDGFEVTDSEGQSHQGKKLILATGSRDVFPDIEGFKENWPQHIYQCLACDGFEQRGTPIGVLDCSSKTAHFTNMALNFDSRVTVLTNGVVPEDAAIKQQLRICEAWGASIDGRKIRRLVNNGPTHEEGVTVEFEEGEPLILGFIAHKAATVNRSQDLIEQLGVECVEPSMGGHIKIVNPMCNSTSVKGVFAGGDTCTPMKQVTVSMADGMKAAAGAGMEIAVEREMATLKLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG30</accession>
    <name>A0A9P4UG30_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_426992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG30"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SPRY" evidence="6">
        <location>
            <begin position="229"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="396" mass="43843" checksum="05AC7A973AC783BA" modified="2023-09-13" version="1">MFKKFKDKLKGEDHSESQHKQEKQHQGPSYQQSNLQSNNPFHPSNYTAPPPWQDQTGSHNITPNEKFQPPQGAPPSYAGASSSSGYAPPPGPPPSKDMPQQPPPSWEPPPYHDWTVIPDTSLLPPPPSIGYDTSPTANATEEDGARADQWCQMNPLWPPQNLTPPMHGAIQNGQLAMLKPPTLTGDVFPMQQAGHWKCRTQTQCRDSALLTNLPMYSVFWDSPLNTHRPKTVYFELKVLGIGSDGYSFSEADAGIAVGFVAPPYPTFRLPGWQRGSLGVHGDDGRKYVNDTFGGVDFTTAFQPGETVGIGMTFSLPREPPSYEQSQMGKVMDIDVFFTRNGQREKGWDGNDELDERSEGGTMGLRGECDLFPAVGVFGGVDFEVFFHPSQWLYRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGL7</accession>
    <name>A0A9P4UGL7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_400591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGL7"/>
    <dbReference type="OrthoDB" id="5418336at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="86"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="369"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="60472" checksum="5E81EE756F5683C8" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGP6</accession>
    <name>A0A9P4UGP6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGP6"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="223" mass="25241" checksum="6FAD97484D71869A" modified="2023-09-13" version="1">MSVDPSLHKTDNVEPFNLSSPAGKDIWRKPPTHNVIDAPTYPSPLPQYDLKSFQRARLTFSLPPGKDLRQYDQAGLLLSFTRDDAPLGSGKDKWLKTGIEWYYGKPYLSTVGCDNWADWSIAPLQDFAGNDSRPTATLEVKRERDELGKSLWVYQIIENEKGEEVERRPLREVNWIFALDEGWKVGVGGAVARPNKELGDEELTAEFAKGVEVELLDYEKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH37</accession>
    <name>A0A9P4UH37_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH37"/>
    <dbReference type="OrthoDB" id="3745632at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="312" mass="35121" checksum="753EE7B938FE3C51" modified="2023-09-13" version="1">MEHSPSQSPLTKPDSESPETSRRDRMLHEFPRAHVTNLGGGTIGPVYLTRTQDGKVLSAEAQLFHAPFTHMVIDSPALLNMFKSPAQRVDLDALGHPWPQFRLEPQEDMTFGVARLAREEYVRSGNKLEYTVKGSPYVSTMEVTASEQVARKRSQPPVSIEVQATRHSERTSAKKRRVSSETYQRQVSLPITYPASPSPGASGSYTVATKLDDTQAEDVISEMSVLKGKIFGMLSADDQSTYEWVLTTGLKRQGKEGAKFRSIVADKLRELMLSQGERSKELQTLHNQYADLQRKLEKRWPYHLPHIDKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH73</accession>
    <name>A0A9P4UH73_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_461615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH73"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="57"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="171" mass="18986" checksum="16C42FD14370FC2C" modified="2023-09-13" version="1">MSPRARLASAFVRPSWCPFRATPIAHQQSIRGKPSTNSQPNPTPHLGSPEPQSFTARLKKLSREYGWTVIGVYIALTIADIPLCFLAVKYIGAERIAHAEHVVVGGAKDLIGRYFPDLALPALWTKLGMVFLVHKSFIFVRVPLTAAVTPKVVKTLRSWGYDIGKRTPKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHY3</accession>
    <name>A0A9P4UHY3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial export protein Som1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_204368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHY3"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10576" checksum="6CC83F8B9BBED371" modified="2023-09-13" version="1">MAPPTPVYPASALPSSINTLANGKPRKPPITDLRECTLKEMVQYKCNVEKSKVKGAQPLIVCDPVVRMFRVCRDGLHVETTAWEGLEARREEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIL3</accession>
    <name>A0A9P4UIL3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_478875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIL3"/>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2451851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="325" mass="36226" checksum="E5630B456ED26D8B" modified="2023-09-13" version="1">MFSSAAGRVIRSSSTLPPPSVCAFARPAALGATQKPFPRPGHQRRLSSSKASTPPDSSNGSSSAPQAPASAEKNPLKKATENDEKMTESGKKQIGRRKKQTTTSAAPTLNVPHVLPTNDVEVSEVKLSSFFSLHRPISMDTFIPPVASTSSFDAIFAPRSPYNKKTTVGNIQVLNRGIQNLEAAMAIHETHAASEEASQVELQRLDGQSYMTLDELTRRLVPFRPPPPPLPVGEATDIYSATSAPLFEIEMPAAENEPEQYEVRQPFLDRMIHRQNRNNRSRDILQRPDMLAISVKRQRKLKMKKHKYKKLMKRTRLLRRKLDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6R6</accession>
    <name>A0A9P4P6R6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_492239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6R6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="214" mass="24298" checksum="762C9FC05D18C150" modified="2023-09-13" version="1">MSLYLFGDNTWRQLQNPSLDIVLFTLQLLRLYLVVYSDQYRNSIGITTVYLWLYFNCTYPRPPNRGYLEAAPTRTSVGSLHYLLFLSFPSLVIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIVISPNIANLQAVPSPNTDSRIIKRLFCPLLIIVSPIFLEITIASSPSESQLCKVPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6S8</accession>
    <name>A0A9P4P6S8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_437506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6S8"/>
    <dbReference type="OrthoDB" id="3763539at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040298270" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11316" checksum="53AF1B15CBDE0DB1" modified="2023-09-13" version="1" fragment="single">MLARYFTALFLAAATLAAPTTSRDAAACTPSQYTISSFAINPSPPNQSIHLAFRSAFPDPSLVTDATLSGSVCDASSDDKGNFPNELTCSTGRGNLEVDLRGEVGSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6U1</accession>
    <name>A0A9P4P6U1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_163162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6U1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="136" mass="15055" checksum="2C85C35FFB48E344" modified="2023-09-13" version="1">MYRTMRYSLKVPRFFTQQTTLKGLPTVYLDQSIPTAHLQNPFPTPLNPSLPLDRPSTALTQLPASNEDPSPHTLSTANLTSSPVYSQRPASWGRNSDEMTTRIPSPGDSNRLAFKTVLPLLQLSGQRSEYIGGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P796</accession>
    <name>A0A9P4P796_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_424555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P796"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="313" mass="35217" checksum="2811475DC9AC7BF8" modified="2023-09-13" version="1">MPSSTMWTTVLQTTALYTAFHILTHHASENIFRDVWENPAVKNFTAIAGNDTIASNATTSKSATTPTDSFSFEKDGAPIDRDTANRLIGEALEDIRKGSDEPVELPLKITLENGTVLNKTVSVPKAQQETKEQESFYTKKLPLDVVAMLIMGVLQYCWLLRLEHALPARSRRRDVVVKEKGEMDEDREEEVVKKWIAQGRVRRASLNWCNTLFKWILNLTVGRAVAYNCAGSFFHITPLAELIAFVAVPAYKQMVFVAGAELAFQVFLVTVVGKLAGWAVQTPFVQDIIRNTTQSVVDSREREEAYRMFKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7W0</accession>
    <name>A0A9P4P7W0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_525957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7W0"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF32">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="62"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="381" mass="42708" checksum="0A296B9B740EF818" modified="2023-09-13" version="1">MLFTTAMASNSECIKRIQANALRDNIDLSVLPFLQDALADISALCTNRTQSPLPTFSNASRIDTHTHPVPSWFRTLQPLSAGRETPSWDPLSHLQFMDQHSIAHSILCVSTPQANAFLRDKAKTIALARLLNEFSAELVRVYPDRFSWMAVTPLPYVQDAMSEVRYALEELGAVGVGVLTNHEGLYPGEESFDLLWEYLQERAEGGDKREIVFIHPHDPVIRLEDGRLVSSKPSPLRSGLGEFYFETARAISSITANRTIVKFPNLHWRVSHGAGAFPDISDRFLLGFPKDAEEARKVYATRFWYDSAGPVYPRQIKGLLAHDVPISQMVFGTDYPYGIGFWDVNANINGLAEAEFLSAEEKNDVFSDNTKSLWKGKINFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8S0</accession>
    <name>A0A9P4P8S0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_423851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8S0"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2438566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="252" mass="27296" checksum="4CCA27B663AFEBF9" modified="2023-09-13" version="1" fragment="single">MAPEAILSHLHRADGSATYTHNGYCIIGAVNGPIEVLRRDEMPEEATVEVNLRPAAGVGSPKERHLETLLHNTLRSIILTPSIPRTLVQITLQVRSLPDEDSSTGVNPSLTLLPHLLHTALLALLSASIPLSTTLTAVLIALPATNTPTASTQLLSPTAIELLRAKPIRSAHVFAFSGEGKMLLNESDGTFSYEEWDEAAEAAEEVCCREDGGVGLAEGIEVDGREGENLDDWLRSVVRTKVEQEQRWKSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P948</accession>
    <name>A0A9P4P948_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Catabolite repression protein creC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_436301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P948"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="410"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="614" mass="67483" checksum="9701A4C2B8FF7A31" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P969</accession>
    <name>A0A9P4P969_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_132318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P969"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="102" mass="11478" checksum="FA0B9A61F16B38D4" modified="2023-09-13" version="1">MNYTKILFHYGLCQTGHCARFVLSAKLQPAGMPMSVQRGDDRWCRRILSHLGKLWCLCRGARARIGRGPVVGTALSIRVTFSPMSVLTYKSLRLGNDQLCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA25</accession>
    <name>A0A9P4PA25_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_97796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA25"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="147" mass="17193" checksum="DDB923B4BF4C392D" modified="2023-09-13" version="1">MNFVRILRSSVQLGRGRRWWTATVRATPHLHLHPVLWLWLCPLPSIIQTHPRRTRPFHISLARPLDRPLFPHQVRSARVLGWGGKRQRRVCADVVVRALQFRKRRRGGRSACVGWGVMSRDVEGSPHRVSWHGRWRGGGLGCWRNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAH4</accession>
    <name>A0A9P4PAH4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_448262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAH4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="273" mass="30627" checksum="E0763A2BB7DB9167" modified="2023-09-13" version="1">MEDADRDCEGTRTAGLPMCPDPTPSRGVKNTPNCAALASYQGLTRTVTQALLRRRKSKLQEPNPRSWSWSSSKTYVSFYPTPRIGLWPLPWVSTCTAINRGGFVRTYSRVLAPGRRRDMVCSHSHPAFHGYGLDPSLYDPGSKVVASSYFLGKVSGPLNVPGYMTGEAITGLFKLQHYLERLLMMSEHHPAHRFLPLRICVPEDRSPTWLSASVRPFASITGPFGQRRGYMLSHSLGTMLTTAEYPRLVFYVHRKSNFKGAQTAHRYLQGCWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAY6</accession>
    <name>A0A9P4PAY6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_435895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAY6"/>
    <dbReference type="OrthoDB" id="3905686at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="129" mass="13997" checksum="B82EF9CB9ECF9404" modified="2023-09-13" version="1">MIAALCPGLISYAFLSGDKTTEATYSVTDKKPIGQVHPTHTPTTHILTPPKQTTYKLTLTNVPDGINSLVNAKPPVGTLTIAAKWRVAEGQLVEEVEIEGNMLVKKMARGNVEKTHPGQHFRLIELAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB20</accession>
    <name>A0A9P4PB20_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">P171DRAFT_420696</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="26">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="61"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="768"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="1043"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1546"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="453"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="519"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1654"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1671"/>
            <end position="1696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAF2440746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1696" mass="192312" checksum="EC25EC98198B9D34" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB37</accession>
    <name>A0A9P4PB37_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_447581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB37"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="426" mass="48654" checksum="6655DC65967ECC5E" modified="2023-09-13" version="1">MQDDDEMQEAFPEDGGLQQELDYPCELLGQEHHQRVLQRNTAVYDSDRNLEVRLGNLGLTCRGTSSGSSHMILDRCPKEAILDLDTAHLQRRESRGFSILRLANRCVGCYIHFQLRRFLEHRGIEAGPQSSVCASQNCNRLPVHRCAYCPLHLSTLLQNSHKSILSHSITQLQEMFQNAIRKEWRIQPQYDVVRKRTGEILQNKRPGTDLIILDDEFSPASQQLWEFAMIELVSGKVLVNTKIDHHRALDRNASTSSSASSLPFWSQISRVKAKGVYSSARNTSLEHMNVDEVAFRLRQVGISPSIVIIVYHVTNFDRTLLTRFLESAGYFGYLPTEENCIPIVNVLRPHLSDRMSSGRRFPLNLEVLFPLMFPRHSLVGMNHQALADCQQTRLCKPVAERGEEWRPDAVARSSQRSILDWLQDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBI5</accession>
    <name>A0A9P4PBI5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_476486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBI5"/>
    <dbReference type="OrthoDB" id="3792543at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040129723" evidence="2">
        <location>
            <begin position="25"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="267" mass="28676" checksum="831BA7A411672F35" modified="2023-09-13" version="1">MKPKSSSRCATWRFLFLTLYAAAGLCTPTAAPPLQPGAPSPALAQPPAPPGPQVQVPPSPNRLPPRAPAPAAAPSPSGPAGRSPQPQPQVNPQPRPRSKNPPARRRSAASRLQSTGVCTFTVSQVQVCTPASTSPPLANYLQINTLYTPYRADAAEVDNIRHQRPMAAFNSYQHLLADQPWGVASVEGDSRTLTIVEGDEGELRMKYGGAEWTDESRGGDGAAGWCEEAEWVEADDWSCPRGEGLAQRKRTVHCGFPCARIERLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBN4</accession>
    <name>A0A9P4PBN4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_525084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBN4"/>
    <dbReference type="OrthoDB" id="3766510at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="272" mass="30424" checksum="1525C48135D2AB3E" modified="2023-09-13" version="1">MSPSVSYPGPMHPFPFPVDLPCGEPYINWPADKNLVLSGTIQTEVAIPDLWVETGVGEDGKTNRTKEAYSLVMPRIRTIACDRTKFVPMYRSKVFETSDENFIKPDKYYLEYMGSPALHTRSKNTCDIPYHLLSFQWRGGGMENYKLARYEGNDWLFHLYSGDTEEHYSMLTREPLIESDVIKVCDGRGRHTNYNKGKGPMYTCDFPDFEGPWTVPCPAPVVEAPKEGSTINLGLAIGLPIGIVGTVVLVILGSYLAPKLKSTFRGEGGIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBR0</accession>
    <name>A0A9P4PBR0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7029 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_446919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBR0"/>
    <dbReference type="OrthoDB" id="3945945at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040150231" description="DUF7029 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="3">
        <location>
            <begin position="128"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1045" mass="112840" checksum="04FB36B08B6F7E1C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCB7</accession>
    <name>A0A9P4PCB7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_456332</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCB7"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="11">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2442390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="99" mass="11191" checksum="CE096B95A0997BE3" modified="2023-09-13" version="1">MPYKPFQSTYYDERMRQSPALLRARAPYLIKNTITGFAICTMVIGIYTYTINVISQDEFDDVVVPDEPVKRSILQMQPSSPSTPSTTQSVQQAVAARKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCC6</accession>
    <name>A0A9P4PCC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_435211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCC6"/>
    <dbReference type="OrthoDB" id="3787249at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="303" mass="33227" checksum="BDB7719BA5B4CD44" modified="2023-09-13" version="1">MPKHKNRESSGSSGGKPYERILRNTAKVNYSDAEILELADPGRAVHQPIEAGASEGYVTACVSLRPLTQYRLPTQAGHVTLVSSSAVNVPKAPANTWVVETSAPLTSPSCINDPNNSPRDTLTYLSKSQLLARRDALLDACTHRANLFAAAIQRFEMYAQFFASACATAHPDGQSGVLLTLRAAVHFADELFPPRRDYTVAVTLLRHFVAGVLHRLHPANETRLTNTRRFNELSHQYEDGENAIRDTMAGIGKVEGGTKAKLEVYMKAFKERGEMLKAQQARLEVLAEECLEEIEEGEGLVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCQ8</accession>
    <name>A0A9P4PCQ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_446268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCQ8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="188" mass="20902" checksum="8CE590EF1880AE38" modified="2023-09-13" version="1">MTIAPPVGEQERGLGGGCSWLVTRRGTVEGPARGWFFSQRRRRAALHSSSSDSGRRRRRHRRRRRHRRSRRTVRQREPHASRPAGTSCGVWPPLAAALLKHAPATRQRPEQPSAPSTVHTGAPARDTHAPALTCLPPPTKAHQSPPKPTRAAHARFDSTRQPSLRNPLPGHQRPLVPWDSSTASPFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDC3</accession>
    <name>A0A9P4PDC3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_446896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDC3"/>
    <dbReference type="OrthoDB" id="3787430at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="270" mass="30280" checksum="6035DF0C020839D9" modified="2023-09-13" version="1">MQNIRENGIAPETVDAAEALTTLVSLGSGEQYVAPRGTSIITGADRTELHSIFTPGRLRGTMHYEATYATMTQDNLGKFLKAISQDPARAEVVRSVKLDLVCDNFLHSGVAELINEDILPFYTFTDDASSGPYPPLTEAALLLKDIQRRMANDPGLSRHPLCPVDLTLLKKDFLYEMDFATNLLATHLDLLIKLCPNLQIIQLPAQWCPILNLPFNATTLTKWKDVHKWELEIKEFVQDDFVRIGKKDGYSVAHVQRWMQQVAEDIVKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDE0</accession>
    <name>A0A9P4PDE0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_475333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDE0"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="55"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="484" mass="52907" checksum="326DA100B878BD00" modified="2023-09-13" version="1">MQNDPYGAILPLTEKASPKQKNHQPNRIRHDLTRPLPRSLPPQNSPQKSTHKRDRMLYEVRVAANKGLGLFAKHTILRGTRILAEKPLIALRLGQRPTDVLGYAKGLDVKSRERLLGLSWHPGNGIKRLGRWGEALGWTMRNRATDEKNARAQGNDTERVSATVPGRLSGLARGLGEAVQILSIFRSNSFNLASSATLPSDVQPSNPVSTGSDTSLGLREATSSTIADQKTAPPSTRPAIELALFPAIARINHSCNPNAQANYHPLHRTFNVHATRDIPAGEEVSINYLPEHGQLRDQRVAKLEDGYGFTCNCPACDLDTEAGRQGEQSRKEMQDSMKNTRALFTDSTAVAETGDAGYGADGMPEALPSTVSVEEQRQIDALRRMPEEDRQVWLRARELEVLNTMLAMYQTEGIVGREVASMYYHIARLQRSTGSDEEAMASAETGLELEGACLGADHPAYLEALALIAGMRDDAAGARPVSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEJ7</accession>
    <name>A0A9P4PEJ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_488333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEJ7"/>
    <dbReference type="OrthoDB" id="3797439at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040215980" evidence="2">
        <location>
            <begin position="18"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="513" mass="47589" checksum="56C0B13BD7A4FCC7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF96</accession>
    <name>A0A9P4PF96_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 299 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_433307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF96"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2442935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27274" checksum="DF54357E70E8C78C" modified="2023-09-13" version="1">MRAAARLLAAVRQGKYLEPGAPTGLTGLLTHPSPRSTLLYHYTSTLDKLQQIPESSVYRQSTEALTKHRLKIIEEAIPAGWARWQERVQNIVHEDPSAFQTIQTSQGTVVEPPKFRDVDPRSREAEWDGEKHVNFPPGMRTQEQRAAHVKAFKGDVNYQPERTLSPIKIPSEPQYTVEAINELETRLGAGLIEEVIQVAEGEHKLVDEMVKAKIWEPLEEQAPEGQWKFFERGASAKTQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF98</accession>
    <name>A0A9P4PF98_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_522538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF98"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="80"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="377" mass="43340" checksum="B65191ED102CB64B" modified="2023-09-13" version="1">MDYDTSKTFREIHGTPSTLIAELDKIEGLALRRSGKLHRAELPVKLRFLTPLLPQPKGHGLNIVHLRLTSPQEHTEKQKYVAVSYTWQQTRCLTATFSNMIPTYKIWDKDIQPVDPKCNPLVIHRAYRFAQRKLKRVLIWIDQECIRQNDPDDVETHLQAMHEIYSRSAFTVVLLSRMVDSVPMAAGLYPFIHGGADIFDKLLRSDDCRDRELCLVALQLLAQDRWISRTWTYQERFFAVACHYAVPLSPALGSNTQDPGLDDWYIPERNMVAFSEKSKHDPAINQDHFGIDLRPSSKIKFKFEASRSTNHKIHLPGFESFLIKSMGIGTRNEILRANANIGAAEKESDRIQGRFETWQIGSQYLQMSVNSTGLYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFI6</accession>
    <name>A0A9P4PFI6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_341899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFI6"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="241" mass="27562" checksum="A0947668152329EE" modified="2023-09-13" version="1" fragment="single">MRLLQLQSDGGVKFAEIYGDIPAYAILSHTWGADADEVIYQDIITDRGVGKSGYQKIRFCVEKAANDGLKYFWIDTCCIDKSSSAELSEAINSMFRWYQNAAKCYVYLADVSIRGWGREHDPEIDDTRTLIFQQRFTRGWTLQELLAPAIVEFFSAEGERLGDKKSLINQLQQVTQIARGALEGDPLSSFSVDERMAWTNKRKTKRDEDAAYCLFGLFDLHMPLLYGEGKKRAFIRLLREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHE8</accession>
    <name>A0A9P4PHE8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_463823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHE8"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="9">
        <location>
            <begin position="217"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="626"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2444075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="760" mass="83201" checksum="CF2C19293C18E56D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHI7</accession>
    <name>A0A9P4PHI7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_496416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHI7"/>
    <dbReference type="OrthoDB" id="5154014at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41521" checksum="BF7597F01DC5DE0F" modified="2023-09-13" version="1">MVFWCMALNSHKAAGKRIRAPGLFQRPSWKFWTCTRAVFQLSAPLLPYPFLYTYTIFWTTYFCVAESLETFTMDYCQALREQPETDAEIVMFVDNGFRLQIPCSQATNDKDLVRLLRMFYELTMARRGVIQIFGFKTSARIDVVQLQFGAAVGAKVGPPLDLGRHGPYNRQIHFFQDSSTLSGTVIRDRLLIESVIRNTHADPQRVPITVSPLEQTRALNIIRSWNPRSASATVAIPVFCSFAVSVIWSAVFTLKYGADIQASVQTGFTIGSYVVTTGAVLIALVAFLDTKYNSNEQASDTGIFTSPPPSPQPSSLQLPRSRPLSPERPQLPISPQPARPRAATIHSHSAPQLFHQRSTQPQPLQALLLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHL6</accession>
    <name>A0A9P4PHL6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_486220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHL6"/>
    <dbReference type="OrthoDB" id="3801154at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2443488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="355" mass="40153" checksum="643FA2D06E27D3A3" modified="2023-09-13" version="1">MAHSALPTRDHFLAHQISVIQNCSICQDDFDTDKHAPARLCGPNSCHHVFGASCLRKWLKSDMLGANKCPLCRRELFVSHNEESESEDEEAETGTFEYDELDAVQVDVDNDQASEQNDDVAGAYRTNLEDVYAPLPNPPRGSPSWSFNNVDRDSEDDDSDFMAFDDGEEDVMDVSPDNHLTSDDEESEFSEGGCPENIPQSEVLLPEREPVFCLGTRANEYWPDNCGSLSHWPDAATITDKIWKNLYSICNLYHIHEDDIEIQVHRALQHSDLRNDAFTIIWCNQWPKILEVGRDMVRQHFKNGKFVQLDDGATSNWLERLAEALDWNLCGEIGEACSLTDEEGPCTGTYRGDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHM8</accession>
    <name>A0A9P4PHM8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_359393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHM8"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000126">
        <property type="entry name" value="Cyclin domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31680" checksum="1178A58AB59C8792" modified="2023-09-13" version="1">MQPSPLANPLATVVQLETSGSQLDGVPQDLENSIRFAGAQLTQAAGMLLRLPQEVIAQALVVFMRFWIGGDGGSLAEFGAEQVSAASLYTTTKLSAWPKSPRSIINAYAYLATLPSLSPPPEQPKPDSYYVSEGTYQTRRTTLFQAEQRILQTLGFHLHVSLPYTLCITYLQALDIFSHPRAAELAKRAVAYLNTALLSPQLLYLTHQPSSLATAAIYLAAKETGIKMPDVEWWEVFDTDREELGFLVVGLLSVESFAEEERAKWEGRSIPMTVEELEAEMKRGDGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI75</accession>
    <name>A0A9P4PI75_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_484202</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001433">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006099">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF119">
        <property type="entry name" value="ROA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1132"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1167"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1245"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="49"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="686"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2445524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1303" mass="144315" checksum="890FB54BFF6A7247" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PII5</accession>
    <name>A0A9P4PII5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_389898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PII5"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="406" mass="43823" checksum="9A4422A213F99AC7" modified="2023-09-13" version="1">MATEQQKRNIVIIGGGIIGSTTAYFLSRHPNFNKERDSITLLEATKIAGGASGKAGGLLALWAYPSCIVPLSYKLHQELAEKHGGVDRWGYRAVHCGQIDMHEILHRNKAPSSMDNDTLDSVSLQKRSEKALGLLRAAGVPKELDWVAAEGFKSYDEMGTPSTTAQVHPYQFTTSMASLAEEQGVNIIYGSATNINQEAGAVKSVTYKSREGAKGKTLDADTIILTAGPWTKTIWPAAPISALRAHSVTIRPSRPVSAYCLFTSIDLPRGNTRRSKTVTPEIYARPNNEVYACGEGDTLIPLPASSDLVEVDESRCQDIVDEVTSISEELRDGEVTAKQACYLPNVSRGGGPMIGETKVRGLLMGAGHTCWGIQNAPGTAKCLSELVWDGKVKSANLSSLDPRKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK18</accession>
    <name>A0A9P4PK18_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_430881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK18"/>
    <dbReference type="OrthoDB" id="3796426at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="246" mass="26107" checksum="427F9FCD2A47B6B1" modified="2023-09-13" version="1">MVQQNDTIAIIVSLFVVILLLLGLIFCCTSRKTDTWSDSSSSTSSSDSEKGPVEPPPTDPDGGFNAPNEQESRRLDPPHGHLPPDGTFNIGSRRPSRADIPPRPDGGFNIDSRKNSRRRSRAREHEGRRPTIPEAPHDQALFIPGPSRRERGILRHERPMGSQGPSRVAFQPSSGGFNAVEGQYGGGNATAQGNDGAFNVGGDTGNTVAAGQPAQPKQRDGQEGSEAVHKPGNRPGSESSGGFNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKR1</accession>
    <name>A0A9P4PKR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear localization protein-like protein NPL6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_359744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKR1"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="490" mass="54653" checksum="D7204456352D37C1" modified="2023-09-13" version="1">MARGRPSRAAARRSTPATPITFDDDDEMEEVVDAAAESRAETPADEEDAGTPAQESEEEEKAASERSATPVVQVLRKKRLGRPPKNRPPDWNVIPDDGSQSGTPVKRKRGRPAGGGFRGRPKGGPVQATRVAIDKEGTMMDVVNDEVDLSEDPEGEKKVDKLGNLQDGRDYRVRVFTISGRGDRLYMLSTEPARCCGFRDSYLFFTKHMQLYKIIIDDTEKRDLIDREIIPHSYKGRAIGVVTARSVFREFGARIIIGGKKVIDDYYETAARERGDVEGELAEPHDKLPPPGEPYNKNQYVAWHGASSVYHTGVPSVPLANGKPLPGKRKVNITSANWQFEHASSSSRFNANLSALRRANLNQGIYDPHTNLMTYPRTTQPTHAKWEEVLQDESDVPPLVRKHYFVVDTLVQKPLYTSLGLPGPDADFLDVGNNGLPDLEEEDIQSMEPEARDTYVQAKQDETWWRDQFQSETVDGARPKLKIGFSGVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKW7</accession>
    <name>A0A9P4PKW7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_276114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKW7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="117" mass="13334" checksum="31AE66D6395A679E" modified="2023-09-13" version="1">MVCKPPCTALYLSSWRYAPYPLDMSRNKKILEKKGGVPRELQYLSCFHETSIIPGARSYIRLEYGPVAVEHASLQSVEWRMFHPIKRMLPQHAAQRAHVRDLALSGVINGRKANSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLP6</accession>
    <name>A0A9P4PLP6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_514460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLP6"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13118" checksum="410C116EC042192B" modified="2023-09-13" version="1">MQTNDMEVFTSTTTRRRGTKDDLTSKATTVLLNMIPQSSNGSIIITSRSRDVAFRLTGGYGDIIQVNPMDQKEAVTLLENQLKANFKKNPSAHRDAVSLVEALDYMPLAISVRGLHVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLU7</accession>
    <name>A0A9P4PLU7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_442783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLU7"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="809" mass="87767" checksum="D85C4F10B0CC39C2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLY4</accession>
    <name>A0A9P4PLY4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLY4"/>
    <dbReference type="OrthoDB" id="5419922at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="352" mass="38312" checksum="D5CD4EAA925F1919" modified="2023-09-13" version="1">MSVPNTETCNPNKDMPDSAGPHLPTSSSRSTRTSQKKKKAKGATPSLRHDHITSPTLASSTGFKYRKVGEGRRAKTTDKPKPRPVTLSSPAIIDQIPAEIPEHEIEPVDEGTEHEPVATAESRKERADIYDVPGSPQEQEQQSCKSSRTSGFSTQAALMMAQSEFQDDTMATIVEDAPTPWLPSTAHEDPIVPSPAFTPFHKFNATLEEHYAPEPAMQDMPISTQDLFATISPFANSTVKKSTKAPASNSRFSVFANREQATPSHGGSRNRGRSPTCSQRKPLQEKNSRVSFLGSQSDKGSQGEKASQESVTGRPSKAPMVQAVGLPQLNFCTSNSDVDFTDRFLINVNEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMK5</accession>
    <name>A0A9P4PMK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S-glutathione dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_462160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMK5"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08282">
        <property type="entry name" value="PFDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="189"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2446762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="390" mass="41727" checksum="50799AE49C608196" modified="2023-09-13" version="1">MGDKMKAVHYEGPFKVSVREVDTPRIQHPDDAIIKVTTAAICGSDLHMYQGRTAAEAGLVFGHENMGVIIETGPGVTILEKGDRVVLPFNVADGRCRNCEEGRTAFCTGVNPGFAGGAYGYVAMGPYQGGQAQYLRVPFADFNALKLPKGTEHEADFALLADIFPTGWHGLNLSGFQSGETVAVFGAGPVGLMAAYSGILRGASKVFMVDTVPERLKQAEKIGCVPIDFKKSDPVEQIIKINGGMVDRAVDAVGYQAVDASGSNEKPNIVLDQLIMVTRPTGGLGIPGLYVPADPGAPDEQSKKGQILISFGKLFEKGLSLGTGQCNVKAYNRYLRDLIVSGKAKPSFVVSHEIDIDDASVAYEKFDKRIEGYTKVLIHPNGPLDKFKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN46</accession>
    <name>A0A9P4PN46_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_243032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN46"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="229" mass="24895" checksum="643F80C2FA84FE6B" modified="2023-09-13" version="1">MLKLARCTHASSALSGFIVAGIHRYISLGRVARCVIAGHVRARDVLACSCLLCWWLLLCMQRGAGSSAAVPCTSSRLRAGCPREGSEDEAMYRRERLWRSSAAPRQRRELVQYRPSSDRALSCPCPRGAPQHTTRRAHRCRCRCRCRCRCVQVLRPSAASTASTASTASTTRSPPQAPSSPPLVPSCARPPSPLLAQGHCLQIQSAVPNSAPAANRRRVCARSSSRFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN80</accession>
    <name>A0A9P4PN80_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_483347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN80"/>
    <dbReference type="OrthoDB" id="3798235at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="286" mass="32108" checksum="8B56AF1A912596E4" modified="2023-09-13" version="1">MCQIRIIYYSCGHSKKFLRGAACSQARFHEHSDGVLYFCPNATIDKVHIPSDCRRQSVLIACQVFPHLDAAQRRVLTICDTRVREVQNYALHTTRRILVALAKWSGGQTFRPNSYPLGKQPMWVGSLLGDYWGHTHMMDAAYFAMEYAHRALSIVVETCQRHILNGYTFIPNRAQILAFPHMAQGLADTILMPNMGWMIIARDYGRGQAVAGVGHPLTLTIRNAPQTSELQHSQLTGNQNVQLSTGQSAPPTNTQPFQATSDGITQTTFHEIDEMIEMISRQHLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNA0</accession>
    <name>A0A9P4PNA0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_276231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNA0"/>
    <dbReference type="OrthoDB" id="5416037at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF6">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="724"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="548"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="967" mass="106806" checksum="18EB65C4695E065C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNC1</accession>
    <name>A0A9P4PNC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_442713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNC1"/>
    <dbReference type="OrthoDB" id="3765731at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="215" mass="24456" checksum="2F04ACCBF5BECE68" modified="2023-09-13" version="1">MSTMDPVDDAIENVTTLANCWLTLLPNFDCGTTGIRVAEVVNEITCEISDDLAGYDLVAEAEYHTRMLRASFLLRDWLKFEHHAKPIIDLGFSNLRLAVNVADLKDPAKKYKYRTPMRLSPAVQELKSKGIVFKTPFGHLMARCLNLETSPIDKTAVATGEIELDEEGKFARFEHPVDLRRHILRGRSKFKKALTDYIKAAFGEERKQMDEPQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ63</accession>
    <name>A0A9P4PQ63_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_206477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ63"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000382">
        <property type="entry name" value="Nitrate transporter CrnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2448122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="510" mass="54952" checksum="EC4AB8C5A2892EE6" modified="2023-09-13" version="1">MGFELRQLWSAPEINPINKKAKSIPVFNPVDKYGRVFFFSYLGFFIAFWSWYAFPPLLSVTIKKDMHLSQNEVANSNIISLAATLVMRAVAGPLCDRFGPRYTFVGCLLLGAIPSALAGTAHNAAGLYAIRFFVGILGSTFVPCQVWTTGFFDRNVVGTANALVGGWGNSGGGITYFVMPAIYDSLVHRRGLTPHVAWRVSFIVPFILITTVAIAMLLLCEDTPTGKWSDRDKAIPAEQHHTAIVATTGNLTDKATAGSISSGDDKEKKTTAGADVEANTGVGQSVDAIDAAHAEIVVKPSGKEALKVLCSLQTVTLCASYVCSFGGELAINSILGSYYLKNFAYLGQTTSGRWAAMFGLLNIITRPAGGFFGDLIFKWSGHNLWAKKFWIHFVGVMSGIFLIVIGKLDPKDLDTMIGLIALMAIFLEAGNGANFALVPHVHPHANGIVSGLVGASGNLGGIIFAIIFRYNGTHYARVFWIMGCIIIALNIVFAWVPPISKAQRMRGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR60</accession>
    <name>A0A9P4PR60_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_217158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR60"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="158" mass="17297" checksum="F020696FF09406B5" modified="2023-09-13" version="1">MRRGAGREDGGTQMAEGCPQPTRIGQLLLSAPSSAAHDDGPSAMRRYTFRFCSACLDIDTPPPRICKLHRNIISLKALPIPGKPFAYYPIFSTPRRFRRLAHQGLQSPRVGLYKHPLIGIGLALEEGTIPSTSPQVIFQIDKAFVVCSPLPSCARATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR90</accession>
    <name>A0A9P4PR90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_518387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR90"/>
    <dbReference type="OrthoDB" id="3691074at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="241"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="486" mass="55827" checksum="32BF19DE20D106A6" modified="2023-09-13" version="1">MSLSSEDASLCERCKLLSFDDLAIGGQKVVDEDGSLRLSFKDTKTEVRPEYDEGYQDLHDYTLIRVGWLLDDILPDMPNLSHSSQLGCAFCSALHRELKEELVQDMRYYTIHDGPLTLIVYLSLVEKGVEGLLVEGTFNQEKGRYGVVQTFFPIEAAPRTDPAFDNCEKWIGAEPARETSYLGPKNISEMRRLLESCTKSCHPWEPSSFLPTRLIDIGIDSSAVPRLIFSSDIRQCEQAKYAALSYCWGTAEDAKTQFKTERGSLERRYENLPYELMTSAINDTIALTRAIGLRYVWVDAICIVQDDTDDWLRDSSQMNLVYRHAFVAFCGLNSNSCHESLLQRAPTIKVLFQSNIRQNINGHYLVRLRPRSGDWVDRKRLDYWCKWRERAWTFQEEELYSRLLLFGSSKMHFHCGTSEWSEGQDNITRSHSSKTLDHITGINQSKMSASNLYDTWLFRVHDYCGRSLTLEKDRLPAISGLACMIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTF3</accession>
    <name>A0A9P4PTF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_381158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTF3"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="175" mass="19338" checksum="B3F2631E29F1858F" modified="2023-09-13" version="1">MASQRVFQLGLRRAAAPSFMIQPAGRMVQRRLANTISKESGEEILAKQRLHRPVSPHLSIYKPQITWYASGLNRVTAVILSGGLYIFGIAYLAAPTLGWHLESQSLVAAVAAWPLWAKATAKFTVAMPFFFHCVNGLRHLAWDVGVGFKNATVVRTGWTVVAATFALSAYYSFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTM8</accession>
    <name>A0A9P4PTM8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_153719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTM8"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2451149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53191" checksum="7DC6ED2A4BF00744" modified="2023-09-13" version="1">MFLANNKKRRKKCDEEKPICQRCRDDQFKCDGYASVPPRKKKPAAQRHTSSKDQTLNPKSTSIEKSMRQITQYYLVSGTLINLDPGAQGPGGSFFHHFRSVTVVDLIRVVNPGDFWFRRVLPMCHDDPVVRQVVVALGAAHRCYLGNLSKPSAGDANAPLTHSEGVAVSLYNEAIAKLTGIGVESYRSGDRELKFLICCLLFVCLEYMLGRFDEAVRHIKAGCQLFQASGLSTAPDDVRKLFQETGTVFLHLIVDATIPPHVYDIPNMLTHAKPLKEIDDASQPFSSLAEARDASWDLDVRMAYSSHGPDNEHKKSFEGLEKPGLQNCNEGWKELSILFAIWRSKLNLLISSLGNVNALPIDLQREVLVLRAQLYMWETILYPDDGLEDEGLRDLCHDHIDLIEKIYRIEASWMGRPVFTLDSDTIPAMFHAATYCKNPVFTERVVGLLRQYRRREGMWDSWKVADMLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTN6</accession>
    <name>A0A9P4PTN6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_218502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTN6"/>
    <dbReference type="OrthoDB" id="3711359at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="348" mass="40210" checksum="995E3C484104C05B" modified="2023-09-13" version="1">MAFQPRYYTQPSFFEHLNYDVRQIIYQFMENHLPPLSHSLKYAGFPLSCKQAYNESRLPAIKGVRQFLEDFQRNFDRYTSTPTRIIPDIPLDSTFTSLRHITIRIPASLVISAFDKQLDKVVVALRPILSAHFQKVTLLFVDPQNEYPTNYKTAMRVSSGFALFRLSQIIMDERKVQSSISALSKYVANTSRYETVHPTSHAQPYPFDFTGTLLHKGNDLPHPISTADIQVAWDWREEELIGTPSTLRGYHHEYSAQAERHEGPTWPQLYIVENDDKSAGMQGIVCKQRWNVSESVRVYWLLQEHRYKSLKGFCWTEGVGRDLQQGLGGMSDKEFQERNPPLVLAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTP6</accession>
    <name>A0A9P4PTP6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTP6"/>
    <dbReference type="OrthoDB" id="3747338at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040306235" description="Peptidase A1 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32512" checksum="11D53B8FFEAA4AA9" modified="2023-09-13" version="1">MLHLLVLAAAFALAAAQGIAEWQKPLPQPPGAANCGRGRKAVHIGSSFSFLMNGDWRYYFTDYFPSDWHCDRGEVTQLHLGVLDDITNRIAPIIHDPYSKGPPKAPKNQQSSLMVTIPLDTEASGPLVLEPEPGWKLFHHMDTSIDILWTSTRQPGRGLNVTSISVSKGVSVSASTGPISLALHTPYIRLPHDVYDFMAKFTSPQPFDMGRGMESVDLVSCNSTSSFPTINLDLEGGAQQILVKPAQYVLHVSQSLGGPFTGKCVLLVKRGGDLEIGYAALRGKTAWLDWANARTGFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU55</accession>
    <name>A0A9P4PU55_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_140423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU55"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="236" mass="26000" checksum="AEA0E0099A04E6AF" modified="2023-09-13" version="1">MMHSLVLHQNMPTTACSPRMFRLPDANQCTHLWRRRRNGLAERATRDGACTCPERGRSRRHRCQHASPTVPCLQRLRSDADALSADEPPRNHFSLDVTVLRAHYVPVNKPGMHSVRCCVYAHPAERASYAPPANGLNRRLISSTRNTQTFPGPLSKCIPSAGSAQIFPACPFANMCSVRAVIRSICRSVGLMRFTHRSTTLDMPISSAPSGALATTHNTLYPGLICTSVPKSTNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUF6</accession>
    <name>A0A9P4PUF6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_440036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUF6"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF8">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="345" mass="39759" checksum="8A29460B4F546E55" modified="2023-09-13" version="1">MELTQQSKKKAPYKRRMTEKRRDQNRAAQKTYREKRKERLEQLELQTTALGNNNRDGRPGGSGPSSMPDIQSGYVIEDSSDINLELPGDNPSVPAPDSSFSDLKHLLKGDDAPDLDELVEFALQEKPDLTKILIAGLRLLKIEKETTMTIEKKRRPVAWATGNWSTLTSNNPPSAIYPLPDPAMNGIFLSRQSQIEVVFYNCMKIGLSIEELMKPTCQSPWYSPISTMPFSALELGRIPPDLIPTPAQIRYPHHPFMDAIPFPWFRERAITLASMDPPAYNLSELKKDVLRGGLVVWRSRGKEEGLPWDRRNWEVQPWFWEKWSWLIEEQGRVEQQSKWWRSMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUM5</accession>
    <name>A0A9P4PUM5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_141280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUM5"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2450522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="701" mass="78440" checksum="E520A4870848698D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV84</accession>
    <name>A0A9P4PV84_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_479019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV84"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="374"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="467"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="471"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2452004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="68827" checksum="D5639640277C6E3B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVF6</accession>
    <name>A0A9P4PVF6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_427229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVF6"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000003">
        <property type="entry name" value="Elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2450962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="843" mass="93893" checksum="992299852589145A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVJ7</accession>
    <name>A0A9P4PVJ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_427262</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVJ7"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2451022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="481" mass="54418" checksum="8B588B4E4E11C2BC" modified="2023-09-13" version="1">MSRGVSASRRFARGNTFAAWRRAFSAKSFSRPALSLCAAPLQAPAQTHCHPALPVPPLTMTQPEPPPQSEYEKKKQNFYTRTVWTFAMLGGFFWALFAGHIYIIILITALQIISFKEVIAIHAVPSKARNLRFTKSLNWYFLGTTMYFLYGESVIYYFKHILLVDRILLPLATHHRFISFMLYIFGFIFFVSSLQKGHYKFQFSQFAWTHMALFLIVGQAHFIINNVFEGFIWFFMPVALVVTNDIFAYLCGITFGRTPLIKISPKKTWEGFLGAWFFTVLLGLVMTYFMARSKYFICPVNDLGANLFTGLECTVNPVFTPKTYVVPFIPPGIPAISNTYVFKPLYLHILVLATFASLIAPFGGFFASGLKRTFKIKDFGDSIPGHGGVTDRMDCQFIMGTITFFYYSSFIAVNHATVGSVLEAAITGLTPEEQVEVVRILGRSLVEKDLFPTQVSSISFYNISKADVDQILQYLTAPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWN9</accession>
    <name>A0A9P4PWN9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF300-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_426707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWN9"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="501"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="668" mass="75387" checksum="A5476602F49F1808" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXV9</accession>
    <name>A0A9P4PXV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_378244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXV9"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF8">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="573" mass="64362" checksum="B4842FE7103EDB6B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYQ3</accession>
    <name>A0A9P4PYQ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_478686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYQ3"/>
    <dbReference type="OrthoDB" id="10496181at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="458" mass="50471" checksum="A1C188D685E9D30E" modified="2023-09-13" version="1">MDSNIYGAMPSIRRGLDSRSSSNTASPSTVAARRLSDPYQTGAGFINAREQDKENAHGEAIPAFGLTYHHPDLAPSRETSTIAPHAPYTVTPQGSATWAVRFAPTEELPQLTSANAPTAKRPASNTDSNPAKKQKVGTSNAGRKSRMKGKKGEDEGFIPNWDRMNTYSLSTLRNKISNTKIIKYLKEQGVDVAKEFPKMNMVYNGEKTTRGVAMAKKAQELHQAHIDQKIAEGQVSVMASNTSRVSRRNIPRALNNRAMVSTTGSDYPEVESQNEAVHNQHKSVYETDHDEDQDVNLDPGCVRLENARQDNDYDSGLDGVCESDDEDAHIIEKPEPTIVSYIRMALRTIKKTAGSDPLNIVIDGLGDPLISVRAQELIFRLANWEKKNSVFQGEAGDGSPHLRNLLLPKEGLDVYQADRRMLVHELAQVFNQGGGVENVAMAFDMAMKLTDEELHTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U524</accession>
    <name>A0A9P4U524_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_373840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001517">
        <property type="protein sequence ID" value="KAF2437271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U524"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF7">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17725" checksum="78B682EAFB919CD3" modified="2023-09-13" version="1" fragment="single">IRVSEAEMKRQGENLTHRVQLTDGDYLGTMSVWHSLHCLERLRKVIHMDYYHDKIPDYKPDTGIWTKDHSDHCIERLRDDIMCHPNIAVYIPEWDETHTLPDGFRMISKGQTTCINWDALDQWARKRALKGGAYTLKPNPFGDEHGVHIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5Z2</accession>
    <name>A0A9P4U5Z2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_437292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5Z2"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="399"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="696"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1073" mass="120286" checksum="73CFD46B0E225AF1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5Z3</accession>
    <name>A0A9P4U5Z3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_371739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5Z3"/>
    <dbReference type="OrthoDB" id="5296720at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="54282" checksum="27BC31553AFE7B85" modified="2023-09-13" version="1">MERLPNELLVSIASHLDVDAPSVKKFSHEPTARLTVSDDTPLKNLSQVSWRWRKILLPILFRYSRIPLDPSPQWVPIDARILDNMQGQLTKLSNHEIQIYTRMMSKFKATGTGSAFDQAFDDVLINLCRVEDDDKVLKSVPHILWFPHLFKNFAQFLQFVEQYDLKNHIKNIVVYTDKEYQLRHVSTADAPLAHAIHEIWDQIFSNLDPNRLVVAAPPSTLSALLDAQMLSSDTWAFDMKMHYVEFLQQDPQRSAHRNRECRPWGNALVHRKPWTHLGYNEGSSITAYSTYEYHLKQSPKMLYLTLLRLAKEVQNCCNITSFSFIGVFPFSTNLNAIIRALQKIPTLREIQVQLAPGPENDLLNTPKRLGRAQSADLWLEWNGCYSALAGLLGTQELGDGARFVSKDCGEKEVAKEVEEYIESLQKRGQGWRKDGHEAWIRDTCLDQEAVPDEHVEDAESALHQLMLAAAHELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5Z8</accession>
    <name>A0A9P4U5Z8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_371568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5Z8"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="279" mass="30951" checksum="92A715F8AED03140" modified="2023-09-13" version="1">MDWLPWAVVPVFIFAMCIYTSQFATSFPTLQGKRILLLIAHPDDEAMFFAPTLLALTRPELGNHVKILCLSSGDADGLGEVRKKELVKSGLQLGLRSADDILVVEDSNFPDSMAVTWHPRLISNLLTATFAPKMAATSSKQAPQASIDAIITFDAHGISSHPNHISLYNGAHAFLKALMHRHSGWECPIKLYTLTTTSILRKYLSIVDAPATVVGAVVRRKELGGFPTPLVFASSPVGYRTAQKAMTTAHESQMRWFRWGWITVSRYMVLNDLKKERTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U624</accession>
    <name>A0A9P4U624_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TRP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_127003</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U624"/>
    <dbReference type="OrthoDB" id="5212126at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040156644" evidence="9">
        <location>
            <begin position="22"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="671"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="704"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2439654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="747" mass="80998" checksum="4ABCCF2C310AB642" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6C4</accession>
    <name>A0A9P4U6C4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_174545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6C4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="108" mass="12068" checksum="A18205730FEED71D" modified="2023-09-13" version="1">MSRSRATCSATATAKHVCHTDQPPVLWAPYSRFRIQDPPSLNPDPDPDPDPHPHFHRLAELVNCIPTRLPCRTVTVTCHCTFPSYTRLRLSTDTVPATKDKSFNACSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6J2</accession>
    <name>A0A9P4U6J2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.1</ecNumber>
            <ecNumber evidence="13">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_458767</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="13"/>
    <dbReference type="EC" id="2.7.7.18" evidence="13"/>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6J2"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 13" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="15">
        <location>
            <begin position="58"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2438067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="299" mass="33384" checksum="3194B395CDF9F990" modified="2023-09-13" version="1">MSATTHDILSNGDDRQPTVDAALGSSDPMSLDTYVFPQERLKRTLSDPTKQPLVLVSCGSFSPPTNLHLRMFEEAADFCEFETNYEVVGGFFSPVGDAYKKAGLAPATHRINMTRIAIRDSSTWISVDPWEPLHKEYLPTVKVLDHFNHELNEVLGGIETPDGQKKSIHVALLAGADLIQTMSTPGLWAAEDLERILGHYGAFILERSGTDIDDALLTLQQYREKIWVIPQLIQNDVSSTKIRLFRKRGKSIRYYIPDKVVDYIYEHNLYVDDDKKQAEKGKAKISPDAQGSSTAATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8G3</accession>
    <name>A0A9P4U8G3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_457855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8G3"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="92"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="525"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="755"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="851"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="615"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="952"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="956"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1134" mass="122145" checksum="2B2C59E0929C20D6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8X3</accession>
    <name>A0A9P4U8X3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_393037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8X3"/>
    <dbReference type="OrthoDB" id="4037694at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2441635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="111" mass="12392" checksum="667C92CCBFB8665A" modified="2023-09-13" version="1">MGFTTGFLGGFTLTASVLYLTISLHTRNRITQAALLRQQQTVLKSVVEPAPPAPEPVARAEPAGLAEMAKDKWNRALENGLKGVYETDWRRVRETAEDRVTATVQRIREQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA40</accession>
    <name>A0A9P4UA40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_49344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA40"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="168"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2442790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="614" mass="67434" checksum="6530127B3E8ED6DD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA45</accession>
    <name>A0A9P4UA45_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA45"/>
    <dbReference type="OrthoDB" id="10654939at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="488" mass="52818" checksum="15E8AE04571436A8" modified="2023-09-13" version="1">MPSDSGCELSELFSDLSSDLSIMNEDVPGESGHADPWLDDSYTPIDDNRDDGSQPPTAGDATLPNEDIAEIVQGGGDDDGSELHTAADAALPIENHAKIDQSEADNDVQRLQRSKAVKEEAARGLETRKKSVEMTRVTWTGRKRVSFSDVGSAGDDSGVEDDYSESGEDVDVKSEADSEEETSQIAIEESGCATEDHEDDGYVETGDQTGRREMFVTASPKMKATSSASFEAPTSQLVAPKSPERLARPKAAAAARVSDDDSELSDPDSNPEDPDGTSTWKEVTAEFQKKINFAQAGAAPEKELVRKASSSTKHNTTTQAESLKKHDLRKKTGTKGTHSKASPTHKTKQTQAEKHDAQKKVRSQHREPKINPPKKINQPPAKRSKSSQGKAMPAVADSEDDVDEIITRTISTAQMRGAIMNLYTTSLQVYHQFVAYASERDGDAAGNAAETAFAGASQINTRSGAQRKRERKKEAKSDAPSRKKPRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA71</accession>
    <name>A0A9P4UA71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_83051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA71"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040240667" evidence="3">
        <location>
            <begin position="17"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="118"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="571" mass="61085" checksum="711CB7FD351F43AF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA76</accession>
    <name>A0A9P4UA76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemolysin-III channel protein-like protein Izh2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_522479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA76"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF130">
        <property type="entry name" value="HAEMOLYSIN-III FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2442761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="272" mass="30869" checksum="6D09EB3A924A2E32" modified="2023-09-13" version="1">MPRILSFDELPAWMKKDPRIRRGYREELRNVWNCFLSLFYIHNEFVNIWSHLLPALVYGTILAKEARFALVDSNSDTGPEKKLIRFYVVTSFALMSLSSIYHIFGAHSERVARHVLKLDYLGIILNVSATCITSSWFGFRHHAHVANMYMSLTLGLSIAIVFLLLKPSADGPKAAKWRALIIAGLMATGYTPLMHAYLAGGIERLQHFPWQAAVKMLSADLVGVLFYITRFPESRFPETFDIWGASHQIFHITVVVGRVVYLRGLKELAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA97</accession>
    <name>A0A9P4UA97_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_496043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA97"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040400435" evidence="5">
        <location>
            <begin position="21"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="105"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="425"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2442821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="578" mass="62099" checksum="1B28A2826B57C4B8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAA1</accession>
    <name>A0A9P4UAA1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_455913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAA1"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="339" mass="37836" checksum="194DDE33206C0F6A" modified="2023-09-13" version="1">MARGELSRTLWSAAEGLRSAPRSQCTRTMRLPYRSLQPAARFISTTPSRSAELTSETPEAQLEPFTAAPEIEFEADEGGDKDSGGGNNQKSNNQLLRTLRVVPASRSYFSAKPTFTDDYLHVSALLRSVATLPTILTTEAPRVAWKTIDQYRIMTNEPVKTQRFHRMMHIVKRLNLVHPSLMPEHIKTAMRRFMKDSQPGDLVPAPQLVDDWGRARGVGRRKTSSAVVWLVEGEGEALVNGKSLSQFFGRLHHRESAVWALKATHRLDKYNMFGLVQGGGSTGQAEALTLAVAKALLVHEPALKPALRRAGCVTRDPRKVERKKTGHVKARKMPTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAG3</accession>
    <name>A0A9P4UAG3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_494804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAG3"/>
    <dbReference type="OrthoDB" id="10649040at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="236" mass="25730" checksum="77A938894D82EA4E" modified="2023-09-13" version="1">MSVENDELPALVGVARDYARCPGPGSRCCYSYSSYHHPVHTHPHTMCTKLYTRSRPCPCPTPCAHPLGTLIACHAWLSTGRCPGSRAVWTGEYTDEPCVRLRLRAKWENQREEEEMVEMWRAEKEREGEEGGQEADVVRGPEVVELDLGGSDKSVEVGEGDDEFGGYSPHASDESIGGDEGEGEGEDGVGGEVKTTGADQDQRVDTNGEGRAGGASGEKSGGQRKTFVDYYYDHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAP4</accession>
    <name>A0A9P4UAP4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_64909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAP4"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="368" mass="41410" checksum="1C3F8C6726F8734F" modified="2023-09-13" version="1">MAGAVRQPIDTASLERYISSNVPEIAVPVEVKQFGYGQSNPTYQLTDKNGKKYVMRKKPPGTLLSKTAHKVDREYRIIHALEKTDVPIPRAYALCQDEKVIGSDFYIMEFLDGRIFEDASIPGVTPEERSKMWHSAVTTLAKFHRVIPKDVGLENYGKPSGFYNRQISTFNTISKSQAEAKDKETGIPVGKIPHQDDMVAFFSDPKTQPKDRSSFVHGDYKIDNVVFHKTEPRVIGILDWEMSTIGHPLSDLNNLFAPYLWADKKQALGSRANEAFLPGKTPGLPSEDQLVAWYSEVAGWDPRPDLTWGHAFSTYRSAIIMQGIAARYALRQASSAQAHEYGSLMKPFAEAAWDLVQEYKRSHEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCA2</accession>
    <name>A0A9P4UCA2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_521076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCA2"/>
    <dbReference type="OrthoDB" id="3769987at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="394" mass="45100" checksum="06F9154A385C8E2C" modified="2023-09-13" version="1">MSPPASMEPVTYGKATRQNIFEKSISASSARYNQHIRHALGFRETGTPGKGMPIFASKNVDQLYHELDQMAQKLPKHSHEELKRAWIRRTYTKDVKRLVKIHGRKIWGDALEVRKLSANPKSQLLTAEDGSKAGDLFYKYERHRKFIALQLEHLLFMKAIAVYNNYYRPSALKATTKPRLVSMRNMHPRASDLRNESDGAMAVEHVLEEAKRTMRMDLAILLYRELCHEDEGSHARLRDAESMLAKSKHLDSIIHNLRRQGEDTLRTYLGASFEQDAQILDAWLSWRKGCWLLSEATGIHPFGGQPTPRFTVEQWKEMFGGGEKCRKIHQTLLSYGRLASSIRDGKDKTTSSTAKSLARVFAAMAESPMLEDSLPDHIIAHNELLSSWKLDFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCB0</accession>
    <name>A0A9P4UCB0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING zinc finger-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_22483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCB0"/>
    <dbReference type="OrthoDB" id="5405791at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056929">
        <property type="entry name" value="Znf_RING-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25080">
        <property type="entry name" value="zf_RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING zinc finger-like" evidence="2">
        <location>
            <begin position="381"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="443" mass="48858" checksum="6AA40EB1D28FD4D5" modified="2023-09-13" version="1">MLAAMPPRASLTGSFSVSDENNVVVCPLRNHDGSACRKRCTGEKRYRSMQEHIRRAHPEHYISKLPATEESFTLMVSTPPQPIQQLQLQHQLPPTTTGPGYDVGEHNAFFHEQYGSMTPRTSDELRRPSLLPAATAAAALASLHNHRPDYDWDSDQDALSDPDSKSYRPRARFAPTTLEHPYNAAEEPYYTATSLQRELLPSSLARSPPGRSSTLPPAPRSIKPNRPRKSSVGQNARKPKHERHRSKDHARRMSYDRKAFSAEPQAAAAILGKRWEDLIDAAASATEEDSRDLTPIPGSPHQSPHMLGRTSLPPFVAAQFISYAASPLHQALTPPPPEMSELQPFPSVESSIESTASAANFHIPSQGLSDSSPTYLHPVQIYCSACRKLSILKESYACSECICGLCQDCVDVLVSEHSRGRTARCPRCGAVGGKFKPFQLDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCS2</accession>
    <name>A0A9P4UCS2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_485906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCS2"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="483" mass="54601" checksum="98828BFC148983A8" modified="2023-09-13" version="1">MEFFIVAGSHQPCQMITVAVENMLEMTISQRMMKTTLLPFESICGLTAIAVQLLFVGWVFYALLRPVIDYSGMLDDPGKDSYAISVVAWIPVVYLAVLSYLVLTWLCLGLHDRQHRPTRITFCISLLAGIASVTAWPIGVFVLFAFVEKEVVLEFLTGTAIIGLAYIACLGLIWVFGEVLALDILIRYQEFKHIIADRLFTMIKCVIHNRYMKCSTDLNNIYRYNFLTFNNSIALAMDLRGARDTTFRVPISSKEFVDVKIHVPTVRAQGLNVLPWASTYVLACQLHNLGIIPPREDGSNIPILELGAGIGLVGLVGSMIWHQPVFLTDLPPVVPGLTSNINLNSKLLQHYNGSARAGSLDWSEPDTLTLHDDTTVSTSETKANIIIAADTIYDEQHPEMLTQTILRWLAPRRDARMIIVYPLRIAYLDQIRELWERLDDVGLEAIQEGKEEAAEVGNTSWDDERLCEWSVWRWRMDDRVHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD89</accession>
    <name>A0A9P4UD89_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphodiester glycosidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_471705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD89"/>
    <dbReference type="OrthoDB" id="5188439at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040424932" description="Phosphodiester glycosidase domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="48967" checksum="E54ABE7E61C818B8" modified="2023-09-13" version="1">MRFNSIPALAAVLILGASGVLSRVIPATRGVESTAHFLAREATLCIKDFCATKGDEKQTRTQCGPVVLTVTHRGAPSSVEECVSQFSNLIAQDTESGTSRTEDTLYEISVEDDTEPAANEKRAVHKKKKAKTTKAKKAKAKTTKAKKTKAKKTKAKTPKACPLPKKGKNGKTIQRRCADDEFYKKRDLLTGKVTHWKFNTMGDIDTYNADANAKEILTAMKKNGQLDVVKISSGDLTVVGNVPEPGLVRGTDPNTFTKKGGNYLLTNGGFFQHMETWLRSYEPAGEDTMNGPIDGLKGTRVHSGPDLKKSIPEIDSKSGIWKYDDNDPILVGRLSHASQDNERLALVRFGTTYYSVAYTCKEKVIGLRGCGFSTNKFKKIIDLFFTKMGQTGKSIHSSTQAVCLDGGPSISMTWNEGHRMEKLSLGGAGDTTPLPSANGRRVSNLIKIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDH7</accession>
    <name>A0A9P4UDH7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_410493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDH7"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000088">
        <property type="entry name" value="Histone H3-like centromeric protein CSE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="6">
        <location>
            <begin position="61"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="17566" checksum="B513F95C7F192B8E" modified="2023-09-13" version="1">MPPKGQIRKNTARPSRPIGASPGSARKKNTAHKTGNPRRSSGGARVSDPGPAPKGKRRYKPGTVALKEIRKYQKSTELLLMKAPFQRLVREICQNVTTEDGPNRWQSQAVAALQEATEAFLVSLFHDANLCAIHAKRVTIQQKDIQLARRLRAAWGIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDS7</accession>
    <name>A0A9P4UDS7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_453838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDS7"/>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6771" checksum="F58DFA97C80D3FFB" modified="2023-09-13" version="1">MGPPKYPPMGNHPIHVHPVRPLYRFMSTALGASMWFFLMYRAKKDGPALLGWKHPWDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDY6</accession>
    <name>A0A9P4UDY6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_440722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDY6"/>
    <dbReference type="OrthoDB" id="3686254at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="534" mass="60602" checksum="4B2C874A457F88B6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE41</accession>
    <name>A0A9P4UE41_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_443424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE41"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="217" mass="23610" checksum="F597E803FDD35BCA" modified="2023-09-13" version="1">MSHSMDMAMSGMDMGTATSTSAMPSSTAGMAMGGMGGMDMGGGDGKACKISMLWNWDTVGTCFLSKSWHNTSKGMFAGSCIGVILLVLSLEFLRRAAKEYDRYILAQHTRSLAEASPGPNSSSDAVNKNVARAATRTITPRSFRPSLLQQVIRALLHMLQFAVAYFVMLLAMYYNGYIIICIFIGAFLGYFVFGWESFNVSQDGKDRMQEEVTVCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEK6</accession>
    <name>A0A9P4UEK6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase RBX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_430675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEK6"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2446543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="117" mass="13244" checksum="498D2BC87A4CE95F" modified="2023-09-13" version="1">MADVNMTDAPAAPKAKVAKSGAGTEGDKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGICNHAFHFHCISRWLKTRQVCPLDNRDWEFQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEL1</accession>
    <name>A0A9P4UEL1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_512329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEL1"/>
    <dbReference type="OrthoDB" id="275936at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32679" checksum="0288010D9C754E7F" modified="2023-09-13" version="1">MTQLVETQSFNRGWRNHQIPGYLAGDVSAAFLSATLISPILTAIDRAVVENVSSTTRPLSTALKENILCTFRHPKRFFVAKPFFYMWTLYAVTYTTANTATTLTGTFMDSSHEILAKSLTFIATCSVNVPLGVWKDIRFVQTFGGRPTPPPTGPVNTPPTKPPPPPQSPTKFPKAVAATFLARDALTILGSITLPPMLAHRVPLADPAAQMAAAQLLVPMLSQVVATPVHMLGLDLYANPGKVEAGERARRLRRGLVGTTAVRCARIVPAFGVGGIVNTGLRGWFRGRVGEGKHSDSGNFVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF75</accession>
    <name>A0A9P4UF75_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_460883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF75"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057503">
        <property type="entry name" value="PH_RdRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF17">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25358">
        <property type="entry name" value="PH_fung_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RdRP-like PH" evidence="3">
        <location>
            <begin position="128"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="430"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1235" mass="140855" checksum="A15E4214F867C0FC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF87</accession>
    <name>A0A9P4UF87_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate-binding module family 50 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_384468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF87"/>
    <dbReference type="OrthoDB" id="2281372at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040224785" evidence="4">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2447248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="192" mass="20727" checksum="788A22A887E770BD" modified="2023-09-13" version="1">MVSFTLTAGIALLVSAVTAVPTQSLVARQATLPGECSNYCSVSAGCTCIRRPTNCVATYLVQSGDNCGTIVSQYNNFTAHDLLAWNPEIGKECFGLQAYVPVCIGVPGYTYPGPVKGGDIWTPEEIPVPVMPGIVSNCSQFEYTDATGVPTLANILSDNKISKQQWNSWNFPTQDPEQDWAVWAQYFSCVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFD4</accession>
    <name>A0A9P4UFD4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_481469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFD4"/>
    <dbReference type="OrthoDB" id="10652318at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="430" mass="50096" checksum="89242206B5B828BC" modified="2023-09-13" version="1">MEYSRSPSPYRHRHRGRNRSSSPARSLTPSRYRYRSPHEGSRQARSVQRQNDYSQFGSRTSAYRSRARSPYQDYARYRSYSIGRYTREQRRNEREQSPDIYHVQFEDGITRVFREVARYPGPPVDPGTTYRYRRASPCYEPVTESRSVPIKQERMSSDHFGDQVASPRGEPVTASRPVPITQESSNRFGDQVASYRRPNLRESRYVVPRVNRNKGKKSKVPSQKQIDALLRGRAPRSVKQENWLREYRRRNFGNNVRPTADTMEAETTRNDQGNTAFVNGFLPIPTHPRLNAYGHPWTNQDTYQQQHKIFLEQERLQTTRREAVENEALQQRYPLIKREPTADDYLPHNGRVQPLRSELGSSSPHPLIKQEFVEPVPNSPLPWIKQESVEPCTNGLDQSDRASSKSSEDHTTSQSNGRGFWGRMIRWAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFW1</accession>
    <name>A0A9P4UFW1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_518724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFW1"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="161"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="256" mass="28301" checksum="F975B11544203ED3" modified="2023-09-13" version="1">MAFHSPRQSQNYYEFNPSTPPPPPPKPSEHSSGTATPQTGPPLPPPPQSSQQSISQPCTLASQTQPRQPPVPPPEDGWLPHVLKDKATVDLHHVLQTAELQHALVHNPETAHPSAPASTAPLQALLAQNVALAESLKQLEAHLQRQRDSTQSRLLSLKASERQWRAKQAEQDEALREFSPPALYQRLSAAVGEQEALCRGLEESFLEGESAGGTDAVASEREVAEFVRRLREGRKVAYLRAERKERWDEGRVGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGR8</accession>
    <name>A0A9P4UGR8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_425892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGR8"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="62"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2451384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="378" mass="40655" checksum="49302AA2E207765F" modified="2023-09-13" version="1">MTSIARSALRAPRLSVAPSIAIARTRLSAVTSHLSGHPNRGFLRTMASLPKTMKGVWIEKTGGTEVLQYKEDIPVPEVKEGQVLVKNEFIGINYIDTYFRSGVYPLPHTPYILGREGAGTVAAVGANVPDDLKLGTRVAYAGQLAYAEYTPVDAKTTVVVPDSIDAKTAAAALLQALTAVTLIREAHPVQKGDWVLVTAAAGGVGLWLCQLLKAVGARTIAAASSAEKRELAKKNGAEVVVDYYEEDREKFTKEVIEITGGEGVAAVFDSVGKATFDSSLATVKRKGSMVSFGNASGPVTGFALGRLGAKNVKLLRPTLFNYAYTRDEFQQYAAEVWKFIEKDGLNVAIHDVYPLKDVVRATEDIESRKTTGKLLLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH22</accession>
    <name>A0A9P4UH22_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_381754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="764"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1080"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1089"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1822" mass="204485" checksum="EB4D9B1FE15C8747" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHD8</accession>
    <name>A0A9P4UHD8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/ reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_427428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHD8"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="264" mass="29641" checksum="12078973993103C9" modified="2023-09-13" version="1">MSLKYNKVLIIGATSGIGLAYAEKVIQDGKQAIIVGRRKENLDEFVSKHGSDKAFPIVFDITDLSSIPKFADDVTKQHPELDCVIINSGIQRGFNFAKPETVDLSVLELEFTTNYVSYVHLTKAFLPFLQKQDKETALAFMSSGLALVPLMTRPNYSATKAALHHFVLSLREQLKDGPGQIKVVEIFPPAVQTELHDEKHQPDIKNGRQFGMPLDEFTEKSWARLVKGEEQIPVGFSEGAFDKFENRRQEVFGFMTKQVREGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHH0</accession>
    <name>A0A9P4UHH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_502632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHH0"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="174"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="680" mass="77061" checksum="1548EC7970D8DBC0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHJ1</accession>
    <name>A0A9P4UHJ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_320301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHJ1"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF2">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE PYRROLE 2,3-DIOXYGENASE (AFU_ORTHOLOGUE AFUA_5G01450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="373" mass="39866" checksum="624A2A242B8963F0" modified="2023-09-13" version="1" fragment="single">PPTLFQPLQIRNLTLRNRIVVSPMGMYSSSPSGNLTSFHLMHHGQFAFRGAALTIVEVTAVTPAGRSSPADAGLWSDAHTASHKRVVDFVHGLDASGGGKAKIGIQLGHAGRKASMLPIYPGRPVVRAEKADGGWPDDVCGPSAIPFRENYVVPREMSEQDIQEVVEAFGKAAGRAVAAGFDLIEVHAAHGYLLSSFLSPASNTRCDAYGGGLRNRARFLLSVLREIRRTVPSTTPLSVRISATDWMQHSPETPQFTLDDAIALALLLVDEGVDVLDVSSGGNNVEQVVPAAPSYQTYLAGQIKTALRDAGKEMVVAGVGRIADARTAEAVVGEGKADLAFVATEFLRDANLVHRWAEELGVGVEWPKQYARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHX1</accession>
    <name>A0A9P4UHX1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_468917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHX1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="413" mass="44510" checksum="8D13763F9A97066A" modified="2023-09-13" version="1">MSCQESDPTPDDHDPMNWSDATKRLTIILVSALTLLASMAATIFAPGVPDLMQEMHSSNDELAAFVVSVYVVGFGIGPLVLAPLSELHGRTILLHCSNVGLIVFSVACALNPSLGLFVFFRLMMGIAGCVPVTIGGGVIADIVPLKKRGPVIGGSLAQEAGWRWIFWLLAIASGTLTIITFATLRETYLPVISKRRIAREERKKQPGHTRNTTQAFCAPSYLYFLFTTFTPVFEGQYNFNTGEAGLAFLGLGVGLVLGVISVGLFAAKYTNPKASKSGRNISPEDRLPPVVLGAILFPAGLIWYGWTTYFRVHWIGTSFVGYGGTLAFLPVQMYLVDAFQLYSASAIATNTVARNIIGATLPLAGGKLYESLGLGWGNTLLGLICVVVIPVPILFIKYGALLRNDARFQVKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI58</accession>
    <name>A0A9P4UI58_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">P171DRAFT_426714</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000019">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000055">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1192"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1581"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1616"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1642"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="22">
        <location>
            <begin position="1"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="942"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="23">
        <location>
            <begin position="1792"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="18">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF2450293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1851" mass="206703" checksum="3DA2AB7C988ED525" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIR0</accession>
    <name>A0A9P4UIR0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_503124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIR0"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF229">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="561" mass="63595" checksum="1CDFA5FD5E1A646E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIY5</accession>
    <name>A0A9P4UIY5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_426591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIY5"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="227"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2452226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="397" mass="43356" checksum="D0BBE4E1D6C89164" modified="2023-09-13" version="1">MPDLPAHTSPAFPPLHSLRPEHPHHLEADDYVLAGATASSSDATSTPPKARRPSQHPPPAIISPAFTPPATPGVSTPSDPRPRPPRSVPVLPSGTDSPRPELLEQLPIVDCEVRARIPTTTGHEMWLHVYRNNVDTKEHLAIVFGNQIRSRSLDREREGETELERMTRGAYVGRLYPGRTHSRVEAIKRAEGAMPKAQPQPQSQSPGSSASSDAGDAAAETSRTELPLVRIHSECYTGETVWSARCDCGEQLDEAARLMSSPHMSPSGGVIIYLRQEGRGIGLGEKLKAYNLQDLGNDTYEANIMLRHPADARSYGLATSMLVDLGLGGEEGIRLLTNNPDKVRAVEGPGREVVVRERVAMVPLAWKTGGEKGIKSEEVEKYLSTKIEKFKHMLTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJF0</accession>
    <name>A0A9P4UJF0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_493798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJF0"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2452120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="710" mass="79193" checksum="7D1A4563E4024A44" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UK83</accession>
    <name>A0A9P4UK83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ash2-trithorax family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_426480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="5">
        <location>
            <begin position="204"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2452092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="587" mass="66075" checksum="A1A23332D904DB15" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5S5</accession>
    <name>A0A9P4P5S5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_505528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5S5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="142" mass="15744" checksum="754B211AFB7805AF" modified="2023-09-13" version="1" fragment="single">WRTRGTAATGQHLRSTSRLLFVSVAAACRGKGLMMTSSWSERWRGQRLPVGRFSGREPCSAPTARQRPPRGSKARQGRRQRPAQGPRRSFPPQASRSPCNSRRPLHYGGVAVGFLNAGRELDLRSWNAGTLARWNAGQILSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6E6</accession>
    <name>A0A9P4P6E6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_490985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6E6"/>
    <dbReference type="OrthoDB" id="3798454at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="184" mass="20779" checksum="D357AC30B5C9C1F4" modified="2023-09-13" version="1">MASHDTQSTSTSASTPSPSTPTPTPTTSALPKSSTTLFTTVPTDLLPRSATSVFTAPVRALTTGPRAVLTLFRGLKHAAKAIVRRRKKHDPMQSRMSQIMHEARLETPEEIDEWEEVDTEDVKEDMRRERLRMKWERKRKEREGAGVGVDNDGDEGPVQVFTRRRKVRHWDDESESDGEVIEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7B0</accession>
    <name>A0A9P4P7B0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_437119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7B0"/>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF21">
        <property type="entry name" value="FLAVOPROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="80"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="575" mass="65746" checksum="D370BE0163096B02" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7R3</accession>
    <name>A0A9P4P7R3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_398073</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7R3"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040390806" evidence="8">
        <location>
            <begin position="18"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="153"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="359"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2438872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="605" mass="66015" checksum="E127FE2606B1AD59" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7T5</accession>
    <name>A0A9P4P7T5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_372569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7T5"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="69"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2438041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="197" mass="21924" checksum="B13B106E2922F701" modified="2023-09-13" version="1">MRFPSFPTLIRTFHAFTNSTFRVANPTRAIYSVPQRATLIRPMPNIPFLGALFGTKMADNTDYPVQKPEGEWQAQLSPEQFRVLRKKGTEAPGSSKLDKHYPDAGVYTCGGCNAPLYKANHKFDSGCGWPAFWDAFPDAVGQRADPGLGMMRTEIVCNNCGGHLGHIFKGERFGNPKDERHCVNGVSINFSPEEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P843</accession>
    <name>A0A9P4P843_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_458306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P843"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="9"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="431" mass="47259" checksum="778848D35495F36E" modified="2023-09-13" version="1">MNETLSYDNQDGVTSDSIFRINSISKNFAVFSALAVENLAKAQTNVPFELTLDSPVRQLLPQFWLPDKDWIDGGRDITLRMLASHSSGLLREGYSTDFNMVLATGKADADTIGAKWAAATLEGVIEYAAKTQLMFAPGQRAGCSVVNYYNKITELNLNWSQLTMQQVLSPLNMIHSFFGSILDALLLDIGVPGGPNWADLVVGLGYDPAAGMWSLSNDLTKYLYNIWLRPDPPNVALPDGKQFVGPGWEIDLFDVAISANASVANKTYSSYGKAGDGGGWYSWIDVVPDLGYGVIKRFAGWYGDGEDSGLITEEVKTNGINGTTYAKVVLEGQILYLRELVVNGSSALEGLDCLGWTDDYQGRYFSTPAGVALTPVWRIMIPGLEVCDWFDFDGYLDNNAWLLGKIVFVESGDGVDLHYPPFDIILSRVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P865</accession>
    <name>A0A9P4P865_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_436562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P865"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF20">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="332" mass="35842" checksum="A0568B0F3395BFBB" modified="2023-09-13" version="1">MPIKTWLTETLGIQIPLVQGGMMWVGKAELISAVANSGCLGFLTALTQPSPEALRQEIRRCKSMLKPSAVQFGVNITLLPAIVKPDYMAYARVAVEEGIRVIETAGDPSPILQFLKENGIVVIHKCVALKHALRAEKLGVDAISIDGIECAGHGGEYDTTSLMLLSLCAEQLKIPYLASGGFANGRQVAAALALGAAGINMGTRWMCTVESPIHQNVKETIVKATEHDTVLCLRKFKNTSRLHKNKVSVEVHQIENTKQDVEFKDVAHLMSGKRGAGVYETGDVDAGVWSLGMCAGLIHDIPTCEDLAKRLEREAMDTLSKTNGLVVTEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P932</accession>
    <name>A0A9P4P932_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_422441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P932"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="508" mass="56621" checksum="433DB9AD403E71EB" modified="2023-09-13" version="1">MAKKTEQDIGIDAAPSVDEGQLAVEKQMRDIGAELYFEVQQYSREELDQERKVVLRKIDWVIMPMICFTYMIQFLDKLSLNYASAYTLIPDLGLQGQRYSWVAAIFNFGYLFWALPANYLIQRLPVSKYTGTMILVWSILLLCHAAAKNYAGILVLRFLLGMFEASISPAIMSIVSMFYTRDEQPLRMCVFLAFNGMATMVGALLGYGLGHAHGTSLKTWQLIFLVIGLINFVWSWVFLWIMPDSPSSAKFLTHKQRIVAIDRIASNMIGVKTKQFQPRQALEAVLDIKVHCLSLIALGCGVVNGGVSNFASSLIKGYGFSGITATLLQLPTGAFEFFLVPLCGVAASYFKNTRCLLLALICLPPLGGLIGIRLTPLSQRWTLVGCTWLQYLIGGPVILSWNLLTTNISGHTKRSTANGLWFVFYAAGNIAGANIFFAREVPRYFSALTGLIACYCGMVVVAGFLGGWMAWKNKSRDRKYGQGEDERAIMEGFEDRTDGEAKHFRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9L3</accession>
    <name>A0A9P4P9L3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA (cytosine-5)-methyltransferase 1 replication foci domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9L3"/>
    <dbReference type="OrthoDB" id="5382953at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="73987" checksum="D1109890E0E8D3D7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA73</accession>
    <name>A0A9P4PA73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_119492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA73"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="158" mass="17696" checksum="514C61D871943D95" modified="2023-09-13" version="1">MEVTNKQTKPSGDGNAMYSSSNIIQLVIPVLSSLAYYLHLPYIHATHQCQDTTYSSPPIQPSTGETLTTPRYCHRPTLLLFNQGKVRSGPITRHVPLSFSFSSTRMCNLHYVYASPSVKYTVKNPRCNPHRSQDAPSSIRNGTRSKLQTVLNKVFKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAH3</accession>
    <name>A0A9P4PAH3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_338630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAH3"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415:SF3">
        <property type="entry name" value="GNAT-FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415">
        <property type="entry name" value="SPERMIDINE N(1)-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
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            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="111" mass="12951" checksum="AA442BABF9FC2BAA" modified="2023-09-13" version="1" fragment="single">GTPIGQIHLNRSSPRMSHHRNTEIGIDILPAYQGRGYGSEAIRWVLEYAFLRAGLHKVRIRAFGWNEGACRLYRRLGFVEEGRERESLWHEGRWWDGVEFGMVEGEWGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4PAQ7_9PLEO</name>
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        </submittedName>
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        </lineage>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:JUN kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377:SF5">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DSPc"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
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            <end position="163"/>
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    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2439963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="201" mass="22925" checksum="239D525BE0F69276" modified="2023-09-13" version="1">MSYLLHGSTLHTGMGWVDSIPRTKNLYIGGLYALYQTDLIKAAGITHVLSVVDYEPGLDKPHLSGLKKMHIWAEDDPNEDLLQWFERTSKFIREGLEYEDGAVFVHCAMGKSRSAAVVVAYLMTRYGVGAEEGLRWVEEGRPVCEPNPGFKEQLKVWEGILKEGDRAERQKMYGEWKEGGFKGSAWEWEKRVERERGKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB19</accession>
    <name>A0A9P4PB19_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3538943at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="53"/>
        </location>
    </feature>
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        </location>
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            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="939"/>
            <end position="1082"/>
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            <end position="19"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1129"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1129" mass="121452" checksum="D4836DF9D8660C6F" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBN2</accession>
    <name>A0A9P4PBN2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_366722</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="2"/>
            <end position="210"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="227" mass="25828" checksum="44C6A2CA49A5AC2B" modified="2023-09-13" version="1">MLEVRACTNDDFADFVRIQLAAFNTGITRVMKPIATVENNEKAIQKHIESATSEPDVHYLKVVDTELDDKIIACAKWRINEKERTEEQIQSMLPVPGEEEKDRPAAQDFMNYLHRVRKQFMGTKPFAFLHVLVVDPPHQRRSAGTLLVNWGLELADKSQLPSFLEASDAGKKLYTSLGFEPVHVETFDLSKYDPNLSGLESNTAMLRKAAPLHRQPSESTQHQRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBV2</accession>
    <name>A0A9P4PBV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_119158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBV2"/>
    <dbReference type="OrthoDB" id="3777260at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="407"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="587" mass="65881" checksum="65F90354FC088E34" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC71</accession>
    <name>A0A9P4PC71_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_475587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC71"/>
    <dbReference type="OrthoDB" id="5309154at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="3">
        <location>
            <begin position="14"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="478"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="555" mass="61975" checksum="392F8F21338CFEC5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC91</accession>
    <name>A0A9P4PC91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_487585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC91"/>
    <dbReference type="OrthoDB" id="10515162at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="162" mass="17657" checksum="C9E9B18D52C073B0" modified="2023-09-13" version="1">MPPLSPLPSLTLHLTTPRHTRLSNALLASPHGGPIRSLPLLLESGTRFYELHIPCLLLYDRASEPTLTTAAMTRAEWATLCEFVEEEGVLKVVLGMEGAGVDVDVLGRVTRDGGVVERGGEEMEGERSVGVRFWWREKGREGAAVGTMVRRGLEWVRGVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCF6</accession>
    <name>A0A9P4PCF6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_434964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCF6"/>
    <dbReference type="OrthoDB" id="3650366at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="348" mass="39434" checksum="0BCF3E9124CD0F40" modified="2023-09-13" version="1">MTTAQSSSARSGHHMVFTIPRTASHLLLKLLNLPEQSSLYRHSNNLDGYIFLPAAAPRFRQSLPGKPIQDWTDGEKAALKDAMQSSFDDWLSLIEQGEKRGKSTFIKEHMNWMASPVAEARLYGHDESDSSTATQFRVHWKCQETNDEGDEDNITCLPDAFLLKLIKPTFLVRHPALTFPSCLRTAIDNQGASAVLDEEKIQQWECTYLWSLSLYTFYTKSAAKFDRQSFVDGVEYPIVLDAQDLGDEALVKKYAKAVGLDEDKVRFTWKPAEEKELGRLGKMDKRMRSTILASTGIEKGKLQAGELDTETLEEEWRSEFGEVLSERLARLVNSNIEAYEALKSARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCH9</accession>
    <name>A0A9P4PCH9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2 conidiation transcription factor-like protein FlbC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_456398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCH9"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2442479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="383" mass="41244" checksum="9303F14E2C798F2C" modified="2023-09-13" version="1">MAMAVDSRQQSQLNGMSYDPLRYPQPHFTNPWVSAAGPSQQQLYQTSIAPNVSAGLENHASSQPQAIQRPTSIAIPYHGLPVTAPSLGSGIALPDGSLPAENLLDMSQDLLSRSYNGGYGTTTSATTNTYAPTSAPYSQVDYGNSERVPYAYSQDTARRSSHPSVPSAPYLDSVMELQRQRQSSLVDFSSLSSQPPRNSFSDALDASRGMVSLSQSDITPRNIYGTQGSSRSSTDSYGFPSTHSAHSSISGASYNGTNYYGGEGSVTDYSSASESVDLTHSRTLPRPSALMGANIPPAPQSMMGQFSSKVSSSSQKKHKCKICDKRFTRPSSLQTHMYSHTGEKPFACEVEGCGRHFSVVSNLRRHRKVHKGEAQDHPSPDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD09</accession>
    <name>A0A9P4PD09_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_500312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD09"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="69261" checksum="7FA16C654468C486" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD10</accession>
    <name>A0A9P4PD10_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_498067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD10"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040132340" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="32"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="345" mass="38942" checksum="8D472E1CBE14A88E" modified="2023-09-13" version="1">MYWQSLLVLALAAPSRAIVRFHCSQLVRERLDPLVEPGANPSAHVHQIVGGNSFNATMEPGKDMPGESTCTTCTFADDFSNYWTAIMYFRAKNGTYKRVPNIGNNQFEKANGGLTIYYMQDAIYDQNQKSNVTAFKPGFRMFIGDVHARTLAEASRYRYLTYTCLDTWTQRSPEMIAFPQRKCKEGIMTTLRFPTCWDGKNLDSPDHMSHMSYPETGTFESGGPCPATHPVRTAQVMFEVLWDTKQFNELEWPADGRNPFVWSFGDATGYANHADYVFGWKEDSLQKVLDSPCYFYTNCSEYGHKLQSVDDMNKCAQKPVVGEDIDGWLDALPGGYHSQYGPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD37</accession>
    <name>A0A9P4PD37_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_434415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD37"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="167" mass="18322" checksum="601A134F23ED6D9E" modified="2023-09-13" version="1">MSHTGNMGTQTAQPNRTNGSVTTTQPVLRLQATSGTLRLRAEPVEQRHIQWAEDVVDNEGMGKKSSKVCCIYHKPREVGESSDESSSDSSSDSDSDSEPDNGEARPAGGRKGANGRRGRNPHNHDHDHDHGEHNNDEPNGGPSGQPQKRPRRRPSPNAYEKMPKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD52</accession>
    <name>A0A9P4PD52_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_390750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD52"/>
    <dbReference type="OrthoDB" id="4148174at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040452798" evidence="1">
        <location>
            <begin position="21"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="308" mass="33375" checksum="1A4B85E52DF70C73" modified="2023-09-13" version="1">MQSFLAFLFTFFLLPILGFAQIEDNDGYTGYKLDIRQDNDPLAVLYETENTKNNVSALVPEPDVFLNASVHVGEIHIEVQNLTAKINLDAQVLQLLSFNAGVDLSIQRVNLLIQNVTAKVLLEARLANLVLMINDTLNSIDLNPILAELGNGLGTIINSTSGLIDDVAGGSSSAKAKRSDMDIQQFQLANNILYSIDDYSGNTHTNRILAQNGDLVDQKLDNSGTVSGSKVVGNYLQNMRFNGFNESVTFRGQEVWEEEYVYEPYTGLMAISGIFKSKSTGQVVGAQVIAEARGGGSATIGSKEQTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE84</accession>
    <name>A0A9P4PE84_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_365956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE84"/>
    <dbReference type="OrthoDB" id="3758675at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="286" mass="30419" checksum="1E690C6792419C6C" modified="2023-09-13" version="1" fragment="single">SIHGSPNGDSATLKLAPGERMAALTLWGNGVGTRCGGVRILTSEGQTFDHGKDTGGQEAYDMDVGSGICVGLNGRSGSEMDCLGFIFLNGKVTNVVISSIQYNPDISGSKQGISQVTLEQVDYTNPPDSGMDVNWSFNNTASRTTSNTFTQTSSTQYGVSTSITIKSELFGTGIENTNTFPWQKTQGTEYASTTSTTQSLSWNLSGVLKPGKIIRAQATCQQGIASVNYTSTVTVQLDNGYTSTYTEPGVFNNVVYTQATARTAPIANNGPDNRRLVVHNPELHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PER8</accession>
    <name>A0A9P4PER8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_47359</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PER8"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040361938" evidence="8">
        <location>
            <begin position="21"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="158"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2442665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="408" mass="42188" checksum="E1F53A00EF8EF840" modified="2023-09-13" version="1">MLNLGRLAFLFGALLPSALAAPVTKKSDLIEGKYIVTLKPDAKVEVQVNWVNDIHKRSFSKRDTVGVEHTYDIKTFKGYAGEFDENTLAEIKANPNVAAVEPDQVVYLPFKVEKVFDKRALTTQTGAPWGLGAISHKTGSSTSYVYDTTAGQNTYAYVVDSGIITTHTQFGGRATLGYNAVGGQHTDTLGHGTHVAGTIGGSTYGVAKKTNLISVKVFEGRTGSQSVILAGFDWAVNDIVSKNRASKSVINMSLGGGSSAAWISAIAASYKQGVLSVVAAGNGDLNGNPLPVSQQSPANAPEAITVSAADSSFRVASFANYGAGVDVFAPGVNILSSYIGGNSATASLSGTSMATPHTVGLALYLIGLEGLSSPAAVTNRIKALAVTGKVTGTLSGSPNVFIYNGNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF39</accession>
    <name>A0A9P4PF39_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_45666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF39"/>
    <dbReference type="OrthoDB" id="4191831at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="567" mass="65073" checksum="57A290EEA803E30C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFA9</accession>
    <name>A0A9P4PFA9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial tricarboxylate transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_521384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFA9"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000092">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="98"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="198"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2443980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="295" mass="31993" checksum="BC879B3DEEAFF27D" modified="2023-09-13" version="1">MATAPSEKKKPSALRSIIAGATAGAVEISITYPAEFAKTRSQLNRRLPDGKKLPWPPFGKQWYAGCTTLIIGNSLKAGIRFVAFDMYKSLLADAEGQVSGPATVIAGFGAGATESLFAVTPFESIKTQLIDDRKSANPRMRGFLHGTRLIAQEQGIRGFFKGFVPTTARQAANSAVRFSSYTTLKQMAQAYVAPGEKLGAASTFGLGGLAGIITVYTTMPIDTVKTRMQSIEARSTYRNSFHCAAQIFKHEGVLTFWSGAVPRLGRLILSGGIVFTMYEKAMELMDRFDPHGRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFB2</accession>
    <name>A0A9P4PFB2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_445590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFB2"/>
    <dbReference type="OrthoDB" id="3482317at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="273" mass="30609" checksum="C4B2DFE13D4B08A0" modified="2023-09-13" version="1">MYLERSKPTFSLPEIYDRKTPPATSPAMIRLSTATVLIALITFATAAEAYALRCKCDTRAGHSGGTRFRPVEVDTRGLDRFSGVQPRGLWWKVVVDSVKSRGLLAQLFVFAVRYVFREMNAVLARFHSPLGCIFSNGVNRAAVLQVNEPKGFVQGSVGHVPLAYMEPNNGNRFADGEFTDAEWTARWSVRRSKRFASVAQTLIATHMLVLPTYNMISDISVWSVMRPREQPSNDHRGGYGGFSLEQQPTMYNSGVVSHAHNLVRNRRQSQLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFC6</accession>
    <name>A0A9P4PFC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_445785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFC6"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2442004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="462" mass="49817" checksum="9F60326387815EE9" modified="2023-09-13" version="1">MDATAGNPGARAGAGPQWVDIPTHLLRAELLRRQEYERPECGTKGNRSYYNTPLHVFALVLILTVSTAACSFPIVAKRFPRFPVPHNFLFISRHFGTGVLLATAFVHLLPTAFISLTDPCLPPFWNKDYEAMPGLIAMVSVFVVVGIEMFFASKGAGHVHSTDFEALGTDEHDGHPRPGHKRTSSYSRFRANGHHHPPDIVLHDLAGSSDNLVAGPSPSFVASPMTPQPGSRTADMGRHYKDGDDEDSDLDIDPDELGPRGSNDSEDESRLLSQPSAHKDTHRSTSPYAEHTPDMTEAQRKKQLLQCLLLEAGILFHSVFIGMALSVATGTSFMVLLVAITFHQTFEGFALGSRISAVAFPAGSLRPWLMALAYGTTTPIGQAIGLGIHTLYDPASQTGLLMVGFMNAISSGLLLFAGLVELLAEDFLSDESYITLQGKRRLQACASVVGGAALMALVGAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFE5</accession>
    <name>A0A9P4PFE5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_82907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFE5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="149" mass="16655" checksum="707FAB2076C31D9E" modified="2023-09-13" version="1">MPFFTALSCLVLSCLVLSCLVLSGLVLSCLVLSCRVLSGLRCVSPHRVREIGLYRRRRKIGIRLSFFLALLYAVCLFPRDVLSPASYRDRETVAWKENQLTTPFLSFCSSTHAITHHVLLSQQRLPPVHPLPFLPDTTAIVSCPDSVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFG9</accession>
    <name>A0A9P4PFG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_464874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFG9"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="169"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="317" mass="35966" checksum="2BD8A1D74EF1A3A6" modified="2023-09-13" version="1">MKRGAIDSFFKLSIPKKPKYETNTNTSSHPSYPHPIPYLPTDFQDQLAFAPAEEGKPINDRLDLDLVYYQPYIPPSIASGVFDFLRQELPFYRVQYNIKRGPVETQINTPRYTTVFGVDETSRFNESGDLVDSKSGKKVEKSKYKCTPRPLPQCLDYLRKLTEGTTNETYNFCLVNYYADGKDSISYHSDDERFLGPDPAIASFSLGAKRDFLMKHKPIPPGPEAVPEPKQVKLPLGSGDMVLMRGKTQGMWLHSIPKRAGDEVKKGRINITFRKALVKGGTENYYQYNVGTGGGFRWSAREKMMVPKKDKLILKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFL3</accession>
    <name>A0A9P4PFL3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_464744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFL3"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2443115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="458" mass="49167" checksum="1F4E41C3D9E34A59" modified="2023-09-13" version="1">MLFSGLALGSDGYNAAVMSNLNLLLTVIYPEALSSDMKARLSNAFLIGMIVGMVGFGVVVDQLGRKTGAVLTTLILLLGIALSTGASGKSPLGLFWMLVVARGIAGVGAGGEYPVAGAGALEASDESGHFRKRRGFLFAMIGDLAAGLGYCFGALVPLLLLLCVNQKVDKYHIVWRTSLALGAIPPLSIFYFRMRMKVSTAYRKSALRKQRTPYVLIAKKYYRRLFGAALGWFLYNWISIPFGIFGSTIVSRMNPQNSLLQNLGWGVVINAFYLPGPFIGGYLSDKIGRRKTQCVGYTLQAILGFILGGAGQQIQTVFPLFIVLYGVFLTLGEVGPGSTVVITATEPFPTSVRGHTMGFISACSKAGAAIGTEVFTAIMASYTDPNKSNQVAFLVGSAFAVLGALNAWFVIQDGSKVLDNEDEIWKDYLVANGWDASWGDHETEDPKLTRDQALLPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG67</accession>
    <name>A0A9P4PG67_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_464181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG67"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="95"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="329" mass="35107" checksum="61B6F15053C2CBAF" modified="2023-09-13" version="1">MSSITATPPSQFDPEYLQWLMSVFPPGATLPSFNTVPEMRPSTEGMIRALYATFPAQPSITQTTHTVTSADGTPIEVLRFSPPHPAGAQEATPAILHFHGGGHVANNVSMFAPALAELASLTSIPVFSVEYRLAPEHPFPAALEDGYAALTWLSTSAPSLGIDPSRIAVMGESSGGGLAAGLALMARDRAFAPRVKKMLLVYPMLDDRSITLNPAWNPEDRTVKMLTMCWGAYLPAHLKAGDPEAKVSPYAAPGRAEDLAGLPEALVEVGTLDELRDESVRFAGRLGEVQGAKVELRVWEGVPHGFDAAREIGVSKRAVEGRVAFLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGL0</accession>
    <name>A0A9P4PGL0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_434010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGL0"/>
    <dbReference type="OrthoDB" id="3797824at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="327" mass="33952" checksum="46B47A84EBB65223" modified="2023-09-13" version="1">MSHRYVCPSVGSIGRPLSSSQRVTASSRCSRGFHASARRPEDQPGDAASPSKSLKDAMTASREPRRQRNVNAATQIGNLSFNRPPPANGVLAKRSGTGPPTGSKMIAPRKPLVRKEATGAPGTMVRAPSTLRITREGGPPAGGPPARRPQGGPNLRARGGGPPGATGARGPGGARGPGGARGPAKNRGGAGGPAKRERGGGAATAGDAPKIDADSITPGAIDGSLMQTLYRQQRNQWDRKPYEPKYAPGSFAANELIHAGRELFKGEAPPVKIWGKLERTLNIVGMHGAAAHLKVRRVLDGDAAPFGKEHENLLESKQSGAEQKTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHD8</accession>
    <name>A0A9P4PHD8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_432045</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHD8"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="166"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2443952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="437" mass="48016" checksum="82FBCDBE5EBC2260" modified="2023-09-13" version="1">MSNADFLGRAIDTVKKAIETDTAGEYEKAYQLYYSALELFMLALKWEKNQKSKEMIRGKVAEYMERAEKLKTHLNQSDDANRKKPSAMGANGKAAGGSGKGGGDDEEEQDADSKKLRGALAGAILTETPNIRWEDVAGLEQAKESLKEAVILPIKFPHLFTGKRQPWKGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESERLVKQLFNMARENKPSIIFIDEIDALCGPRGEGESEASRRIKTELLVQMDGVGKDSRGVLILGATNIPWQLDAAIRRRFQRRVHISLPDLPARMKMFELAVGSTPCELTQADLRKLAELSEGYSGSDISIAVQDALMQPVRLIQTATHYKPASIVDGLQQWTPCSPGDPAAKEMSWTDLDGAQLAEPPLRCKDFVKAIKASRPTVSKEDLTRSAEWTKEFGSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI21</accession>
    <name>A0A9P4PI21_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_484115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI21"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="418" mass="49323" checksum="19CD048B1385599B" modified="2023-09-13" version="1">MYFDWSSIFHSWFAAFVSLPFTVFTIIIFLCRITGLEKKILERWEGKEGKRRRENEKIAAEREAQAGNPRGRRDGEEMVERVRRDAKKSMEDKMKGLEWEFDQKLIEVREKEFWDRHKEGLEWGMEEGRRRGVEEEAERREKYKKEFLEKYEQKMFDSPPPYPEPLYREPLYPEPSYPRPPYPGPARSDFTVESVPETQLRRYILELLAFTFDADFLLLNEALGQTPSPMNSNSILTEVEHAELLRLSTFVQDLGTDLPRLPSTWISQSEGVAAVKTAILNPSTKLVSRKQTPWMLAIISTYAAHRCQPERRALSYLEQNKPLMYNLFRRMTFLGLFNSPMCLFGAKLCEHTCMIRKMAPNDRVRDVLKRAVEDYQREVLKIKDTARTDCWFMGPSWGTTSNWELMEYDVRVRDGEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIW1</accession>
    <name>A0A9P4PIW1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_26527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIW1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="246" mass="27539" checksum="B8D6D112314654B7" modified="2023-09-13" version="1">MQHPDDDDDGADTGGHGDGGEENDEILYPDSDSDDGGMEPRQNNDGQQEIALAELMRDVSKVDKGAGLYRIALAQPHRDFYDPNTERQFCEWAIKSAILATEDKADPLVFVPDLPEAMQSTTRVARFREIPEIIEKIKAISNPDRIRGSVPPDEEIRKETKDLPSRFALKSYVRDSTQETASTGIVDMSSNLYGIYHGDGEQRWTTSEPRTRCTLRPTLRVTNTDSSICPDTGKLSIRCCRTYARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJH0</accession>
    <name>A0A9P4PJH0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_485351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJH0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11661" checksum="BED0C816ED03A14F" modified="2023-09-13" version="1">MSSTPTSISKYTFRGPTHMTRHRDATHAPFKCPKCDYIAATYGSLRTHIDVVKENKASKKQSKDKERCGMGCGKKYCTKAARNRHEEGCEYRKVGDVGGGDTATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJK1</accession>
    <name>A0A9P4PJK1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_483617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJK1"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rhodopsin" evidence="6">
        <location>
            <begin position="75"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="6">
        <location>
            <begin position="147"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="312" mass="34279" checksum="40D2A29EB7F94002" modified="2023-09-13" version="1">MSSSAVPAFTPEYLASDKGPRILTILIVFPVFGSFDRWTQAVHTTRGSSQVIIRGLDHRISVGMTDENVLYSNKLINVIQIFSIATSMCQGYEAKNGMGRHIQVLTPGQGIRPLKALFASIMMYNFGLTLTKASIVLQYMRISIGHNLRRREKYTLALILGPGGFASIASILRLNTLHELQSTRDISWDNPGTATWSVIEMNLGIICASLPTLREIIIHHLPRVFRSTWVAAPSANIEHQTGGGSGGTAESDSSQLVYVSTGRHSAATDVHDPFSYMDIGKSTFYPSDSEQGYVRNDWVSMTIAQLILTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKR4</accession>
    <name>A0A9P4PKR4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_288907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKR4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="208" mass="23075" checksum="DDAC8AB63C843F9E" modified="2023-09-13" version="1">MLSPPRTALSQRRTACTIERGADPNRLHPARAFYRRASHFRVSTIPRPLDYQPPALVPSWQPAQGPGHAMECFPLRWETRCSTSMAAVFSFHPSRSATLSLPPRQRSSNMGRESVSTGPADHVRARLHALHTWSRTVYLPYRPELATARSQGRGCGEDVAAALVNNCSAGGHASFRVALNRSPDPPSIECDPWVLHHGQYSTSWNSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL31</accession>
    <name>A0A9P4PL31_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_430005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL31"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="76"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="388" mass="43044" checksum="5AAC5D8C06CC54CB" modified="2023-09-13" version="1">MSVSSLSAKSSAESLRSISSFGSAPDKLAPSVEGPMVWKNSELDPTKYVVNLTVAEVSEIRYAVISIKLQKMEPEQISKENFPLSEELSAKLAAASKQVHEGFGVAVIRGLHAARFNDEEAVIAFVGICAHTCPLRATDSYANQTLSHVLDATFRKVPHWAKDIGLAGSKITAKMDFHNDRFSGDVLAMHIRDDGGAGNGGEQYLASFWSIYNELLEKDPAVLETMAEDKWPFELKQKDAAPYLELGPTLLFSKGKPMCQLVKAPLLGGLYIPRDPSMPELSKEQMHAIHAVEEVAQKVCAKLDRQQGDIQLINNLSVMHARAAYGKTDGPSTRHLLRMFLRDPQNAWDKPDSWKHNFDDPFTPGRRQEIPIRDLDPWRKISGRESHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLF5</accession>
    <name>A0A9P4PLF5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_453770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLF5"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000895">
        <property type="entry name" value="Hsh49p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000505">
        <property type="entry name" value="Splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="103"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="302" mass="32236" checksum="8614795A7D30AA7F" modified="2023-09-13" version="1">MAGPAARHWEQNKEATVYVGNIHEDVTQQLLTELMNHHGRVRTINMPVDRVNGKHQGFGFVEFATEGDAEYVISILNGTRLYNNAIRMNKASADKAKSVEVGAELFIGNLDSMVDERSLYDTFLRFGQLVSAPKIARDELGLSKGYGFVSYADFDASDAAIANMHGQYMQSKQISVQYAYKKDGQGARHGDDAERLLAKQAKAHGVAPAVQPLPAHLFQAPPPQAPSGPRGVPGMPSGPNSYAGPPPRAPPQAPPSLPPLPSGLPARPPSGAPPTTFYPPPPGFPGGHPPPGFAQPPPGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLT1</accession>
    <name>A0A9P4PLT1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_430683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLT1"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2446551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="493" mass="53915" checksum="1122225175705FC8" modified="2023-09-13" version="1">MSSSTPQSQASMLATITTDLDKIAPRFEVQPEQIEILKTPSEFYDTLKDKISKAQSRIYLSTLYIGKTEHDLITAIRTALLANPTLTVSFLTDALRGTRETPNASCASLLAPLIAEFGSRVEVRMFHTPNLTGLRKKVIPNRINEGWGLQHMKLYGVDDEVIMSGANLSSDYFTNRQDRYHLLKDARLAAYFAKIHAGVCALSFDIQPTDTQAGYSMTWPTSNPAPSPLASPSAFKKAAAAHLSPLLTPSNSPTPNTTKANTTIYPILSLVPLLPSSTELPALTHILTSLSKPPLHPSSWTFTAGYFNMTPAFRRLLLHTSPASGTVLTAHPFANGFFGSKGVSGMLPDAYTHLSKMFLGKVRHAGLADSIALKEWQRGKVGEDGGWTYHAKGLWVTFPSAQPAAEKADEEDPSLTVVGSSNYTKRSYELDLEANVVIATSDPGLRRRLGEEVKRLGEYAHQVDESEFEKPERKVGVSVRLSMWLVRVLGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM96</accession>
    <name>A0A9P4PM96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_383634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM96"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="10">
        <location>
            <begin position="23"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2446791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="399" mass="42637" checksum="630970FA6C7E3F62" modified="2023-09-13" version="1">MAADRTPDVQQKESQIRASVLHGAGDLRIENRSLFPPGPTDVQVAVRSTGLCGSDLHYYRHYRNGDIIVREPMSLGHESAGVVVAVGSEVEKSQKFQVGDKVALEVGQPCEQCDRCKEGRYNICKEMKFRSSAKAFPHAQGTLQDKINHPAAWCHKLPENVSLDLGALLEPLGVAIQATKRAQLPVGATVLVFGAGAVGLLVAAMAKISGASTVVIADIDSGRVNFAVEHNFAHRSFTVPLKRGQTIEENLEIAKETAAEIAKTTKVSGGAVGEVDAVFECTGVPSCVQASIYATRPGGKVLLIGMGTPIQTLPISAAALREVDIMGVFRYANTYPTGVEVVSKKGPDYPDFSKLITHRYKGLESAEEAFNMAGKTKDDNGNLVIKVLIETGDGDRANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMQ1</accession>
    <name>A0A9P4PMQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_441846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMQ1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="295" mass="32105" checksum="E70B450F4FD6613B" modified="2023-09-13" version="1">MVPALECGRDDGPPRQLLLVAAVGDGRGLEPDLDLQIARSSTERERPMRACCEIRGPPKNAWREHSVSGYGSGKQREYVRRITHAPSPSPHHPPSPSASASPMLCASERAGMAAWLRSPAVRGAATTSSLSAARPALETVAGRACAQQSEHGMPYAMGHVWRYSLYVRRRVRLLLHYVHGRPLAPDLDMSIPSSPNSPSNMASPTSAHDSSATPALSMTPAPRARLASDGPRLNRTPALATPRNSCLRRPLRPAGAADEARSRRIMVARLQQPSRCMHKRPWSCIHHCYQASHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMS1</accession>
    <name>A0A9P4PMS1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMS1"/>
    <dbReference type="OrthoDB" id="3705926at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="490" mass="56172" checksum="36339D7B4EB4D52E" modified="2023-09-13" version="1">MASFPDHPTELINSILQHLSFRDLLTVCLVSKRLYECATPLCYSQIDLTIYRDNLRSIIHLCRSIFNKPELAAYIDSVRLRDGEPADGRRYCDISKIPEASPPRPTDEDGMSEFVPFISHSGLAYADIWTEKVRAGDLNAFVALFLSRLPNVKSFHVGTLVTLPDPEKKELGRDSPTAARDMDNQFLGKIFQSAVFDPSNHGISRFQYLEHILYPWPITPWPGKNPDFCKPKDMIALLSLPSMRSISGWCLNPESLQFSWPVWPAGPLELAYLTSLSLTHIHVNFLGQILERTRALKELRWVWKHTPDVDPLNADLMDLDRFVEVLLAVQDTLEDLNISVDMIFPWSTPDFQDLETRGSLSGLRSMVNIKRFKAPFGLLLPDGDGQKDWDTKRLEDSIPPNVEFVTISDDDTDLGFIDQDDEWPKIRSWLSETAWKTTPHLREVRLFLQKSSDAVRFNKLDELEAIFQGIDLPHQIVHESEASHRWDWDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN06</accession>
    <name>A0A9P4PN06_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_241894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN06"/>
    <dbReference type="OrthoDB" id="3799500at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="273" mass="30337" checksum="92F621766786A947" modified="2023-09-13" version="1">MSFHETPHCLRDTVFCVYHHFAIPQGTAVDYQVEIRTLSLGVYSSFFTAQAVAVSALELNLKRLQSAGFKGKFCNDIDLWRRGLITQITEYGQERPLSEYEIQAIPLQDCAVPGDPFLGVSAQQIMIPKPIASSSSKKMPPTASEIAQDPFWAQSRIPYFRKRDEGPFRSLDDPPYAINFSLNIQISEACKQAATGGGANDNDNARAGTNIPQQDITPDRILEAQTKPEYTDFPEKQRSKQTEKEGANGEKRLGGGKDIGPIYHGRRHSTSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN23</accession>
    <name>A0A9P4PN23_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_380692</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN23"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="99"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="458"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
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            <begin position="67"/>
            <end position="77"/>
        </location>
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            <begin position="78"/>
            <end position="88"/>
        </location>
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        <location>
            <begin position="254"/>
            <end position="272"/>
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            <end position="292"/>
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            <end position="478"/>
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            <begin position="504"/>
            <end position="532"/>
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        </source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2448150.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="642" mass="71113" checksum="F35C8D0E1C78820D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNA1</accession>
    <name>A0A9P4PNA1_9PLEO</name>
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        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2447137.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
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            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
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    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
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    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS_13"/>
    </dbReference>
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        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        <location>
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            <end position="20"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="529" mass="58225" checksum="B86F72480E89AC0D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPF0</accession>
    <name>A0A9P4PPF0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_354450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPF0"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000104">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000174">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="84"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2447717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="554" mass="61083" checksum="CDED46E4C9307600" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQW7</accession>
    <name>A0A9P4PQW7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin/actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_429336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQW7"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2447718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="439" mass="47711" checksum="C62E7600763EB23E" modified="2023-09-13" version="1">MASQTPAVVMDNGTGYSKLGFAGNDSPSFVFPTAIASKAPAGGAGGSGSGRPAVANKPSFLTGGAGPGGHLHAKRGTEDLDFFIGDEALSAAAGPGYGIHYPIRHGQIDNWDLMERFWSNSIFKYLRVEPEDHHFLLTEPPMNPPENRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVHDRSLTGTVIDSGAGVTHVIPVAEGYVIGSSIKSVPIAGRDITNFVQSLLRDRGEPDSSLQTAERIKEEFCYVSPDIVKEFSRYDREPDYFKKHTVNQPNGKSVQVDVGYERFLAPEIFFNPEIYSSDFLTPLPNIVDTVIQSSPIDVRRGLYKNIVLSGGSTLYKDFGRRLQRDIRHLVDARIKASEARSGGAKSGGLDVQVITHKRQRHGPWFGGSLLGQTPEFKSYCHTKAEYDEIGPSIVRRFALLGGPGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR23</accession>
    <name>A0A9P4PR23_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_518161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR23"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="625" mass="67696" checksum="5F9E7869C0816AEB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR87</accession>
    <name>A0A9P4PR87_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_518920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR87"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="75"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="417" mass="44476" checksum="29BCAADAE28B54C2" modified="2023-09-13" version="1">MASRTRLVASTASGLIRASRPTLVSRTAAPLALRAFTQTHSPAVQSATGNPLSSFISANSPPAYFSSSRSLPANTIIRFVPQQTAWIVERMGKFHRILEPGLAVLLPVIDRIAYVKSLKENAIEIPSQSAITADNVTLELDGVLYTRVFDAYKASYGVEDAEYAISQLAQTTMRSEIGQLSLDHVLKERANLNANITAAINEAAQDWGVTCLRYEIRDIHAPEPVVEAMHRQVTAERSKRAEILESEGQRQSAINIAEGKKQSVILASEALRAEQINMASGESEAILLKATATARGIDAVAQSIAQGKDAAQGAISLSVAEKYVDAFAKLAKEGTSVIVPGNVGDIGGMIASAMAVYGKVNNGNAKSVAANMLQGGEDTAAGRKIAELEAQLEEVENGTGDVQNAIHKAMDQRLNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS71</accession>
    <name>A0A9P4PS71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alternative sulfate transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_451527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS71"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="488" mass="54797" checksum="CCA847238AA0E602" modified="2023-09-13" version="1">MVDVEKVDIQPSAQSEDGSNHVVNMVHKDTAGLRARRKVDITLLPLLFLGLLVFQLDRMNLASALTDGFAKQIGVNQNTINLGNQLMFLGIVLLEIPANMILQRIGPRKWMSAQVFVFGLVATLQVFIKNRTGFLVSRTFLGLCESGYIPGGIYTLSTWYTKPELAKRVAIFFFGMFGGNAISPLLASGILKLGGRGGLKGWQWLFLLEGCFTMCVSLILLFLLPGSPDQPRPLLSGGFIRFSESDQHALQRRLEKDNEELKPGAQGMRIPPSLIWKTVKNYRRWPHFVSTFAVFSTWSSLTTYTPSIIMALGFTRIQANALACVGGFFALGIVFFFGWLSDKTNKRGLAVILAQACYLLILIIARSVHPHVGKWSRWGLWTTINAFAIGYHPVHNSWVQLNCKDPRERSISIAMWVMSAISGLMAGTQYLRADDVPFYHKGLRTMIILVAVGMIAAIVQEVVYWDYNRKVRRRWEQNGGEKPWFYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS83</accession>
    <name>A0A9P4PS83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_188583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS83"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="343" mass="39029" checksum="494722F19E39500F" modified="2023-09-13" version="1">MAEKMEYVNLGKSGLKVSKVILGAMSYGDPKWQEWVLDEEQSLPLLEHAYKVGINTWDTADIYSHGASERIIAKALKKYNIPRSKVVLLSKCYFGVNEEDPTLGIAQVSTNDGEFVNQVGLSRKHIFDAVEKSVERLGTYIDVLQIHRLDRDTPREEIMKALNDVVEKGWVRYIGASSMAAWEFQTLQNIADRNGWHKFISMQNYYNLIYREEEREMIPYCQDTGVGLIPWSPIARGALTRPWADRSSKRATTDNFLKNLVHDREDAVDKEIIGRVEKIAKKNDVSMACVATAWTIHKGVQPIIGLSSKARIDEAVKNSKFKLSEEDVKVLEEAYVPKTRQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSB0</accession>
    <name>A0A9P4PSB0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_194609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSB0"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040167058" evidence="1">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="2">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="210" mass="22009" checksum="F2720E0BC46D9A34" modified="2023-09-13" version="1">MKLSTLLFGGIATLVGAQTATAYTDAKSGITFQAYQHTTGYFLGVALPEDPTGNTDFIVTIGGKGSGWSGASLAGPMKNALLVLAWPNNNSIVSSFRKTNQYGSPPVATGTFTQLPIANGTYTNTTHWTYTFVCSKCIQSDGTTFVANDNTTVLGYALSSTAPSQKGNAASSVSKHTSQGQATFDLVKARSRDFATWKTWAAAPKVANAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT15</accession>
    <name>A0A9P4PT15_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_441067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT15"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="290" mass="32851" checksum="A560DC2403A2213A" modified="2023-09-13" version="1">MPTASNDMSNDAPLSAISLPAELRNQIHEYLAADVAANGVLHQYSGYMLCSKQTYQEVSSIILENLNNTLAAVENGYYKQIDAILKIDKPTNIPYDQTPFGPLLDIHCSSLVFYLYDDPAWASLSEGARNSSYQTLEFNIKWICKWVSSFRLPYAKLYNLRATTQVVSTDGRYPKRRSVHRMVNAPMLKFEWGLTLGSEEWQAATERIYVQDCCPAILIGGPRWRYQIYRSDGTTTDIKGVVRPERLIEPVMPGRVPTIGIVLNRIESQGIVGRLVEKGVFAMRAMMRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTF4</accession>
    <name>A0A9P4PTF4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_380092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTF4"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="68"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="513" mass="56850" checksum="58C74ECA74BA0282" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTI3</accession>
    <name>A0A9P4PTI3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_202687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTI3"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2449912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="696" mass="77007" checksum="56DB3F84A0B559EF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTW4</accession>
    <name>A0A9P4PTW4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_428209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTW4"/>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2450122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="822" mass="92077" checksum="BDD2CD9311D117CB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUA1</accession>
    <name>A0A9P4PUA1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-galactosidase</fullName>
            <ecNumber evidence="10">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_402657</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="10"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUA1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040432975" description="Alpha-galactosidase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="12">
        <location>
            <begin position="369"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2450327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="450" mass="50448" checksum="223673C16796D782" modified="2023-09-13" version="1">MATRLLSLSLAFLAPSLALVSKDGRTGRLPAMGWNSWNEYECAINETVFLEVGELLLSLGLKDLGYNYVNIDDCWSDKAYQRDNVTGKIRPDYIKFPKGVKHTADEIHKLGLKLGIYGDAGTTTCGGYAGSLGHEEVDAKSFAEWGIDYLKYDNCAVPSTWIDSYRYWPENWLGGPPAENQTAGGPGEAEPIAAPAGYDWTTSKTFTRYKTMSNALLATNRTIEYSQCAWGHAHIEEWGSSTGHSWRMWGDIYPVWEGTVKWSWGLMPILNHASFWNNDTNFWGRGDWDMLEVGNGNLTIEESRSHFALWAALKSPLIIGTRLHGIKPEIVKILSNKDLIAFNQDLLVGEAAKPYKWGVNPDFTWNQSHPAEYWSGRSSRGAHVFALNTLNKTVTKIIDFAEVPELNKKKKYVVFDSWTGKKKGTFKGRYKARVARHDTLAIRLVEAGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUD4</accession>
    <name>A0A9P4PUD4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein 70a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_379338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUD4"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="617"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2449433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="653" mass="70860" checksum="45B7D25427107944" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV98</accession>
    <name>A0A9P4PV98_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Iron reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_440302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV98"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040308578" evidence="9">
        <location>
            <begin position="22"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="287"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2449853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="506" mass="52745" checksum="BF6BDDE54D8B0939" modified="2023-09-13" version="1">MGQRRNVLAAGLVALASHAVAQVGSICPTTDVCFKLNIPENTASSGDGDIFFQISAPDTYNYVALGQGSSMSGANIFVVYTAGNGNVTLSPRLGTGHSMPQFNSDAQVTLLEGSGVSNGKMVANVRCSSCNSWSGGSASFSGGNGNWIYATKQSGGAQDTTSQSANIDEHDNHATFPWQYANAKGGNSVNPFVNAGSSGSGSASGGSGGAATSCVPRPAGAAVTGTATTGTATNGGSSRATSTKTDDDDDGSHYGRPTNFPSGWTRPTARPTGNPWEGYDKRALLEERQEVNYCDESSDPSNTEFSPISSGNAGNSQKMLIAHGVLAALAFVIFFPTGAIAIRLASFTGVVWFHAAFQAFAYIVYIAAFGLGVYIASEQRMLSETHPIIGIVVFVVLFFQPILGLLHHVMYKKHHARTVWSHLHLWLGRAAITLGIINGGLGLQLANNSPRAGFIAYGVIAGVVWLVWVAAIVLGEKRRARAAKDAHLARGVHAAGGHYAPKENGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWB4</accession>
    <name>A0A9P4PWB4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_375549</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWB4"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="486"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2451407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="961" mass="106120" checksum="6B2367E915824DAB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWD7</accession>
    <name>A0A9P4PWD7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_402875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWD7"/>
    <dbReference type="OrthoDB" id="4115389at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056669">
        <property type="entry name" value="DUF7767"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057940">
        <property type="entry name" value="Tri-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24962">
        <property type="entry name" value="DUF7767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24465">
        <property type="entry name" value="Tri-helical"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Tri-helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Tri-helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7767" evidence="4">
        <location>
            <begin position="543"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2450468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72361" checksum="0FBF9E3DC62DBDC8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWV5</accession>
    <name>A0A9P4PWV5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_438420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWV5"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="24"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="197"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="396"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="811"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="720"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2451740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="908" mass="100016" checksum="695413EBA79BC4F8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX73</accession>
    <name>A0A9P4PX73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_14743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX73"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="558" mass="61943" checksum="B6077F24155FEB24" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXH1</accession>
    <name>A0A9P4PXH1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_349062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXH1"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="7">
        <location>
            <begin position="181"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2451023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="542" mass="60678" checksum="A16063B8B3F230B4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5D3</accession>
    <name>A0A9P4U5D3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_459000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2437885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2437885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="783" mass="86154" checksum="6A883AA9E83510D4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5T1</accession>
    <name>A0A9P4U5T1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_448197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5T1"/>
    <dbReference type="OrthoDB" id="3792087at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="856"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="896"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2439354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118356" checksum="F777BD1EDDD1EB89" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6C0</accession>
    <name>A0A9P4U6C0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_437059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6C0"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="448" mass="49286" checksum="0E1123920B81BF3C" modified="2023-09-13" version="1">MASPTKESQKVLEGIFAINKPQWASSAGVLRDLQTHFDKSTLFAPWITHTKRAMELSGSKKRHIQNLKVKLGHGGTLDPLATGVLIVGVGRGTKCLSRFLECTKSYECVVLFGAATDSYDAVGKIVSKGEYQHVTKELVEEKLAQFRGKIMQKPSVFSALKVDGKKMYEYARAGGDIPEVPARPVEVEKLELVEWLDSGSHEFAWPKEEIDGTEKVGAERLLGIRKKDADVAASRSKKRSRSPEDALVIGENSLSKKPREDGEHSMSGALPVETGSTEVSADAAPVKAIPTEGPADEAPAESTSANGTETGPAEDAQPPEPSPAQTSPPPNPPAVRLRMTVTSGFYVRSLCHDLGLACNSLGLMSSLIRTRQGDYELEKNVLNYSDLEAGIDTWEPKVQNHLEDFMEKEGWEAEEVLNEEEWKEKAKEQRRDSDRNRSYRGGGKNWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U772</accession>
    <name>A0A9P4U772_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_423316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U772"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09000">
        <property type="entry name" value="GH43_SXA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="326"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="540" mass="61076" checksum="1860818FFD11DB04" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U793</accession>
    <name>A0A9P4U793_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="5 20">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">P171DRAFT_397174</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 20">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Chromosome</location>
            <location evidence="2 20">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5 20"/>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15 20" id="KW-0779">Telomere</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="23">
        <location>
            <begin position="1895"/>
            <end position="2501"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="22">
        <location>
            <begin position="2614"/>
            <end position="2925"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="24">
        <location>
            <begin position="2955"/>
            <end position="2987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="174"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2893"/>
            <end position="2943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="2898"/>
            <end position="2908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF2438938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="2987" mass="335794" checksum="9E9A23CCACAA8F28" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7F0</accession>
    <name>A0A9P4U7F0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7F0"/>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="720" mass="79783" checksum="FF6FCE2BC571D8EE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7N4</accession>
    <name>A0A9P4U7N4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_434126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7N4"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16494">
        <property type="entry name" value="RING-CH-C4HC3_ZSWM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="229"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="341" mass="37948" checksum="93E486C2ECDC220A" modified="2023-09-13" version="1">MPPSHSVAAHGARAAASQSSRKRKLVVYLDDSDDEDYGHYDKTSNFKKRKSTGTHDVIDLTADDDDDNNYNKRTKSTPKKAQGDTGKDEEKRLRRFRSHPPQSYLVIKERALSQRLTVISRERVGTDDELEETVTMAGSTGNVYKQRIGHVPSCDCPHAKKGNQCKHIIYVMLRVLKAPENIAYQLALTSSELRDLFRHAPPIPSADSGTDDGNEAEMDGNRKKIEGECPICYCDFEPGKEPIVYCKAACGNNVHKSCMQSWIAAKGAGRATCPYCRAKWEDSDAGGSFSGKVDLQGARRTEEGYVNIASQLGLSGERDYSGYHRPWVRQQGYGGYSYGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8L9</accession>
    <name>A0A9P4U8L9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_433936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8L9"/>
    <dbReference type="OrthoDB" id="10006285at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="115" mass="11944" checksum="2535FC88182A8272" modified="2023-09-13" version="1">MHDMNSIRSAATASYARMWSNDPTAFAEPLYRVSSRNTRIMSSTPIDLSANGDPGLIDLKSAGNFVYALSPGNGTTEAAITVLDVSGGQGSAKQAQHFCLAGFATSSAQGMAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8S5</accession>
    <name>A0A9P4U8S5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal trichothecene efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_367725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8S5"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2440347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="593" mass="63188" checksum="8346A7A68B03E6DC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8U7</accession>
    <name>A0A9P4U8U7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_73861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8U7"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000019">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="30"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2441560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="38198" checksum="AB6548CC7BD6D984" modified="2023-09-13" version="1">MADKESFLHLARPLGPAPLGAQPSTAPLNVVVQPQAIFSILDHALRRPADQERVIGTLLGTRSEDGTEVEIRNCYAVPHTETAEQVEVDMDYQKQMLQLHLRANPREVLVGWYATSSDLNTFSALIQNFYGQQGDGTWPHPAVHLTVSTDPGKEIESRTYISAPIGVTAERAADSCLFIPVPHELKYGEAEKSGLELISSAKDREDRSQPIITDLEALERAITHVLEMLDRVSTYVNNVLDEEAEPSSALGQYLMNALSLAPKVDAADIERDFNNHIQDVLVVSYLANTIRTQIDLSNRLATAALTLGTGDAITGDGEQQQRGGDRQRGGRGGRGGRGGGQGRQQREQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9V0</accession>
    <name>A0A9P4U9V0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_72446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9V0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="90" mass="10157" checksum="EB8553442398A514" modified="2023-09-13" version="1">MRGDISSEARAKTRNYPSQQTRCLNSTMSSSPLLRAHEPPHEPIGESDKRMSSLRDKLVYFFSTRTFHYSVLLLVALDVGCMFAGTQTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB01</accession>
    <name>A0A9P4UB01_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_43323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB01"/>
    <dbReference type="OrthoDB" id="2522477at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="424" mass="47902" checksum="CF774F124CBCE4A8" modified="2023-09-13" version="1">MLVFPDDDDDKSAECKHDRLGVLPDELLLQIFETLAKFGTRKDLCNVSRLNKRYHRLSDATLYKQVLFQTPELHLTFSESLGRRPRRGSAINEVTLAYPSSELSQLALGAHVPGSYIHPSRFDGLSRTLSIMSNLEKLDIAVPSALLHGIGSLFNGPFDLSCLKSCKLFYQCPNDEYWDLRENIHIFAHPELEELTLRRAKFDEQGFNSLERPHETALKKLHLIECDINDDGLGDLLELPEALEEFVMTHQEEPEPELEESSDSVADYIQALKSQSESLTSITIDSPSMTSRKVLRMREFGALKTLRLNWDYQLFAKSSKKPRLHSVGLPPELEMLEFFNELGTDAEVNDLLLALIESKSIVARHWKTMVVIEGDDAILKQVKTACKENGLQLDIIGAFDETDSEGDESMGSDSRDNTDSEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB13</accession>
    <name>A0A9P4UB13_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_485166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB13"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF226">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14479" checksum="C9DC2607BEE9FA72" modified="2023-09-13" version="1">MEKALSEITQYISIPKRHHVWPAALRLFVDEAHRICPLTPGTLWRELSAGDPGSTEPLLIDDLYTIHHNEEHFSESFVYRPERWLDEGETAETMTARKKLREGFSPFGLGSRSYAGKAVAYVKPVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB21</accession>
    <name>A0A9P4UB21_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_431878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB21"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="278" mass="29622" checksum="7F29AEC865082437" modified="2023-09-13" version="1">MSTVHVENISTKTTQDEIKSFFSFCGKISDISVKATDESSQSASVTFEKPAAAKTALLLDNTQLGPNSVHVTASKSIDELAGDKAASAEEAKDGDHHIEQEEKPRARIVAEYLAHGYTISDKAIEQALALDKQHGISTRFTNVLQNFDQRFQATQKAQAVDTKLGVSDRVAAGWRGLNSYFDKAASTPTGQKLRQFYETGNKTVLDVHNEARHLADLKKTGGEKSSSEKATPHQITGSTATECNCSSDSGKCGCAPGQCACSGCGKSEDKTAVPTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB63</accession>
    <name>A0A9P4UB63_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_431971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB63"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="483" mass="52567" checksum="84278AE811260842" modified="2023-09-13" version="1">MSLSYFNVKKFRRQSKQAEPTEETVEKAVDAAVGKPVSPPAPAVGTPSEEPAASPVLDEEDEKFMARLAAIAQEPEGERPPLPTRPVEVVENGEKKVGRDAQEALMDGADKVPLPTSPPAVAVSDADKEGLGRKKSVMGYFALAQARFKKATDKKDADGRVKEKDQKKPAITAKDKQRAADDLLSAAESAKTEEQKEKEKEQQDLTAILDDLNLSAVNNRVFSFSKESEELFGKFTLVLKDIVNGVPTAYDDLEKLFTDYDANLKKMYGNLPPFLQNMVKSLPAKMTAALGPEILAATAEKPGFDAKQKQTWQDGAKSFAKKKAKQKAKIPTLKSLLSAEGAVATMLRSILNFLKLRFPAILTGTNILMSLAVCLLLFVFWYCHKRGRETRLEKADREKDLLSAEGGNSALASSASSIASDADSIFASNANIRHNGESSRQGALEEEAQPPLVISDEREQEKPRATVADLPSVKDLPDPAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBU0</accession>
    <name>A0A9P4UBU0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_277179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBU0"/>
    <dbReference type="OrthoDB" id="5342588at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="397" mass="43252" checksum="0583406A616266DC" modified="2023-09-13" version="1">MGIDTTLRLHWTQRIALVRHNLHAARRTNDFTFFKTLQAHAIIDGTDHVAILHSFLGNDADSVLSTLDNLNAGIAYVHQDAFKAVYDGAKSTMYKADNSPVSRRSLLRVDICQQRDMADHAIDKTANSAVQLIHDQPVHCQDAVANAWITGTTIMADAVCVCLNEMEAIEDNLDDFIRLEYSWNSIQSSVDAAISALRGIFSLMERSHLSTNFSRNLSVSSIVGSEGSASSFRSRNSSTASAFAGLIKRAFSQSHNMGTPPPAAPKPGRINSLSVPNANPRTLRLSMSGSCPTKMSTYTDHPHTMLTTIPPTPSVHETSTATANPFRTKGDYFTFNMDKDVEKTNEENSPSPSDLMQIESLDPLYSPPADNTGKTLLPLSLRRLSAQFISSPAAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC30</accession>
    <name>A0A9P4UC30_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_474044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC30"/>
    <dbReference type="OrthoDB" id="2823490at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="316" mass="35052" checksum="1B06846842B4437D" modified="2023-09-13" version="1">MPSLMTLPPEIRDQICTHAILTPNTPTSISQSSEALLPSRVELNTPHIRAWSHVVLYERKPPNTTTDSLLQLSKQLRTETQATLAHLAASPPSYTLDLIILNETELLPTWTSVPVATTRVDTVDVALRISGVHEVKGWRSYEGFTSGNGLGPAMGWQLYAVLERFLRVGVRGETGDEDTHMHVAANCIRIDVQTPPGVAAAQFGPPLTSLSPLRNKNGGTVLDPGYLVAYVEENLEGLLAGGNYKWFTCGQILFEHVGEIVVCKDGVEVRRWDIAEQLRELGDIPEQYFSAEQLRGYKKKAWQARRERGLKFLESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCM2</accession>
    <name>A0A9P4UCM2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_432007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCM2"/>
    <dbReference type="OrthoDB" id="10466371at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24882" checksum="C375193C45C55A02" modified="2023-09-13" version="1">MGTQNVQTRVCSIAELVESILHQADMSPLDLLLARRINKTFNDVIIHSLPFRRALFLEPNPDGMELDIDPSKVEVNPFLRKIFPQATKDYFDLALDPIKRKHFLLVGHEVLVCQGKLCKVGNSNRVRLAYLDDNRCFVHLPRLDTNDEEDYFTRAQWYEHALWRKMYATRPNLSTHVVWKSPIYHQYDIVHEATLGEIVSAVVTGQVVFSTPEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCP2</accession>
    <name>A0A9P4UCP2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_385859</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCP2"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040171018" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="211"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2445370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="603" mass="67359" checksum="626DB455067B6EA7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCY4</accession>
    <name>A0A9P4UCY4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_279121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCY4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040462074" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7250" checksum="ABE721201DA50196" modified="2023-09-13" version="1">MTDGYHPLCFAVGAATWLWCGFAQSKQRAPRQSIVVWNCHPQHFTLTHVRANREGYSAYIAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCZ3</accession>
    <name>A0A9P4UCZ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_285229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCZ3"/>
    <dbReference type="OrthoDB" id="5546837at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2444863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="190" mass="21354" checksum="35776DB377EC88D7" modified="2023-09-13" version="1">MANFAPYQDIPETTRALSPPIASPRTSLDRTRNIGTTAVTSPTSQSYQQRDYFGSDDVEEQRERVAWNAPLGGPREDVDMFSTSIGLRMDHAACLAYLLLPPAGPVALLIFEHRSDYVRFHAWQSSLLFAFIFVIHIIFSWSSIISWFLLIGDLGLIGFLTMHAYQDASTLDRYEIPFFGPLATSITDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD63</accession>
    <name>A0A9P4UD63_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caib/baif family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_431823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD63"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="445" mass="48096" checksum="87660F6462DFAD07" modified="2023-09-13" version="1">MLFRPSKQVLRSSLTHSRCNWSAIQSRRCLASAAYNENGTLPLAGIKVLDMTRVLAGPYCTQILGDLGADVIKIEHPTRGDDTRAWGPPYAKYIDSNQEGPGESAYYLAVNRNKRSIGLSFAHPAGVDILHRLVKECDVLVENYLPGSLAKYAMDYATVSKINPGLIYASITGYGQTGPYSNRAGYDVMVEAEFGLMHITGARDGPPVKVGVAVTDLTTGLYTSNSVMAALLSRIKSGKGQHIDVALSDCQTATLANIASSALISGQKDSGRWGTSHPSIVPYKAFKTSDGDILLGGGNDRLYGVLCTRIGKPEWIMDARFKTNALRVQNRDTLEGLIESETKQKTTAEWLDILEGCGMPYAAINDVQATLNHDHTIARGMVQQIEHPSCGPIKLVNTPVKYSESTPGIRTPPPTLGQHTDEILRDTLGMGSEDIESLRSEGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE49</accession>
    <name>A0A9P4UE49_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_409409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE49"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2470" evidence="1">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="228" mass="26451" checksum="459E0E0F5D5F201D" modified="2023-09-13" version="1">MSTPEAQEAVISERIVKHMNADHADSVRRYLEAFKNKSISEVRDARLTSVTLNEMNFEVAGQQVTIPFDPPMKAMREARERLIQLDKDALNALNRSDIPITKYTPPYAPGLHFIHIFNFTQCLLVLVIFSRRANFNPGSLVYDHLLSYVPGFGEFCLTIQPYLFWIMVSIHATETVFMARKLNRHGLTSSERIWWAWMGSCFVEGRTCWMRLDTLINEKLKEREAKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEJ5</accession>
    <name>A0A9P4UEJ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_357229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEJ5"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000119">
        <property type="entry name" value="DNA damage and replication checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="202"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="801" mass="89264" checksum="775731E16910E7EC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFK6</accession>
    <name>A0A9P4UFK6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_429231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFK6"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="96" mass="10875" checksum="E92A9CB4AE0848BD" modified="2023-09-13" version="1">MPNLTAPKLHDPFSSSLRILSYGLRRLCIFAVIDATFFLPDDGSTPSWPYLESMNIKFHMASPSGTYYFRGSRNALRDTGYEIHPETSYPPLEQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGK0</accession>
    <name>A0A9P4UGK0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_480367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGK0"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="183"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="284" mass="31757" checksum="E1625FFD1765D77F" modified="2023-09-13" version="1">MPVAKTLGVVGSIIAIVQISKTIISLCHFYIDSVDGAPQELRVILIEVSTLKAIAKSLQYLTQPNVANSTLLDQLAAISGPIEGCKKALKELEKLFPPTPTPVSGNGRNSTRRKLDAEIIQHKTTINLALTSELVHDLKDVKQKAEQIQNLLTEDERQQIQRWLVTTNPSGIHNRFQNLYEPGTASWMLRTPEWPLWIEGKHRCLWIHGIPGAGKSILASYLAEKIENYCTASSSGSSKLGHAYYYCYFGHNQDEASHFLRWIIGQLCRQYKDPRGTPENIQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH26</accession>
    <name>A0A9P4UH26_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_186967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH26"/>
    <dbReference type="OrthoDB" id="5398233at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="42"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="544" mass="60335" checksum="F59A982FA618C835" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH82</accession>
    <name>A0A9P4UH82_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_427526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH82"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="157" mass="17349" checksum="ED2D7A2583751626" modified="2023-09-13" version="1" fragment="single">MRSYFAGRCTQSRCCTALGPWFSLLINNAGIGNSSCILDLSPKLLQTLVGLNLISHWFTVQEFLPDMIAKKKGHVMATSSMASFVGMAGCGDYAATKAGLMAFHETLTQELKHRYKCPQINTSIVYPLGIRTRLSVTIQRQYGNTLKKPEDIAKIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH99</accession>
    <name>A0A9P4UH99_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">P171DRAFT_15727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH99"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2451969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="97" mass="11063" checksum="269BB19F3E360C6E" modified="2023-09-13" version="1">MDEREEASNEPLDLVRLCIDEIVVVKLRGDRELKGRLHAYDSHCNLVLGDVEETIYVAEEEDEDQPPRVRTVKKQSEMLFVRGDSVVLIAPQEGVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHH3</accession>
    <name>A0A9P4UHH3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RSE1/DDB1/CPSF1 first beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_516156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20774at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="1">
        <location>
            <begin position="65"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1422" mass="157229" checksum="5C917DB02BA03C1B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIE7</accession>
    <name>A0A9P4UIE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_142158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIE7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="75" mass="8732" checksum="54450FCD542FC582" modified="2023-09-13" version="1">MLWKSFLSILFMAPIPKPWGFLPRPHHILRTLNFSSLGFPQLSALYLPLMLSLFFDAFPREVLPGPILEEFPFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P3K5</accession>
    <name>A0A9P4P3K5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_437704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P3K5"/>
    <dbReference type="OrthoDB" id="3799282at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="356" mass="38478" checksum="D3858F4169EFF00E" modified="2023-09-13" version="1">MSPATLDAADAVMRALRAIDALDPDMASAALPTASFLAHLNIDIADATAQHAHPRRPTLDAVARELRPDKQLALQPPADMAPSASADMCTALEWADRLAEHAYSIGYTVAKHENCTTPATAVTTFGPCIVDPWLAALYEPLWDLSHAWRITYGLKVGDGCSGECDVGKCFGEYCHENVVGCILPVRTRLNADQPMHLGELFCALMLLHRQLKRNCSLGKTVTIAAVTTEGRIRVHEASVHQPTAADAAHTIRITKCVDLHITDVTSQDPVAQDGWLNVMSYLCFTHEANLPSNHPDEPDEQPLQVDVAATQQDNQDITWPEEENIQPAALDMGGKAATKPAAKAATPRKPLAPLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P494</accession>
    <name>A0A9P4P494_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_372089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1487"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="736"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1286"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1101"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1115"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1149"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1287"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1842" mass="201509" checksum="0AFF0449F708DC8B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6E3</accession>
    <name>A0A9P4P6E3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_424263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6E3"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription elongation regulator 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
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        <property type="entry name" value="WW_dom"/>
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        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="583" mass="66596" checksum="265CFF54E7DA3084" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6F2</accession>
    <name>A0A9P4P6F2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_372528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6F2"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
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    </dbReference>
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        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="30"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="257" mass="28908" checksum="B0B646528CEDB917" modified="2023-09-13" version="1" fragment="single">MSDADVLRFCCNLNRHEYPNAPPLAECTLVVCLDTEGWVSDADSTALKEVGMNTFESRDMTALTSPGPWGVNILNNVYFYFARVLKHAHLRNKNFSAGDPDTNRFGLQRFLDDTEVIQFLKSTFEWPLDKDTDDGRVCPVVLLGHAVENDVEKLEKLLQFTARNIVKQIDTQVIARDVGHWNHPANQIGLQRLVGDMGFAFRDPHTASNDAAYTTISAIQLIIDDQFKGAVQPCTLQSVINDLERNSEYHLWDHGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6S6</accession>
    <name>A0A9P4P6S6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6S6"/>
    <dbReference type="OrthoDB" id="5382058at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040427478" evidence="1">
        <location>
            <begin position="17"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="459" mass="49795" checksum="7F27115F6F1855EE" modified="2023-09-13" version="1">MLKFFSLFWLVSQSAAFNVDLSTLLVRQTAAPNQLPDGVLPALAFERSTWVKGSVSEDPFYQVAPGWADADFGTVFRVEDMDPTLYTIPPTTSISRILYQSKSFLGKKTPASGYVLFPYSPRKIKGGSVPVVVWGHGTSGLHPESGPSHLRDLWQNAQGPTPLVQQGYVVVAPDYAGLGVGKNAAGKNITHEYLTGPAQANDMEYALKAARSAFSFLGKQFTTIGHSQGGGAVWSFAERMRTNPIDGYLGGVAISPVTRLLDLPQGNPIKALLVAATLPTIANIYPDFNISSVLTPEGAQRFALEQKTGGNVQATIALLLTMAGFPILKDGWEKNEYIQRFQAATGNGGKPIKGPLLVIQGDNDFNIDVRTTTAAVEKTATANPKESISYAIYSNITHASAVWVGQQRYLDWIARRFDGEAASTGFSRDQVSSLRPWAKYQAEQNFYAARATEFYQVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7L3</accession>
    <name>A0A9P4P7L3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_371502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7L3"/>
    <dbReference type="OrthoDB" id="4181307at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="429" mass="47322" checksum="1A136AF84E7C2EE7" modified="2023-09-13" version="1">MHSKPVVIPPRTPARPGIASATQSVKVRGHNGRRPQRAHKNHAPDAIPPAVAALLAVTAIPKMPPRRRKGSTRDRRISMDELIQEWKQDDSELPASVVGSPLDLLLGRVDESEEEYGSLVSDEQEKDCAQSVTDRSISSESLYTMPPSLDTNAPSFASHWDELSTPDSYQRSLPDRRGKAVSSPPAEDCVLDHPLLHFTSDDGDDIASFDMPDPVTPSPASSERFRSFKSNLTASLQALKSAAKSFSNFTAPSVPPDDLLTRSILLPKFTSEMRPKHMQGLPSPELRRYLNPPSAPVSPTELSMQLYDALAMNVDEDPSAPMIQMQTYERRNRSRGRRKAADPSPDASRAQSEPPTVRQREPRENSDFLRVIVLEMNMRRVGKLDSKAVGKARIWLPPRKIGASKAPAVQGPAASRVPDRWVSVFADEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P884</accession>
    <name>A0A9P4P884_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase M14A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_371691</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P884"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 19" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040147807" description="Carboxypeptidase M14A" evidence="17">
        <location>
            <begin position="17"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="18">
        <location>
            <begin position="124"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2438513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="429" mass="46305" checksum="91DF3DDC533DFF79" modified="2023-09-13" version="1">MKFLAPLLATFGLASAAAVNSKVSYDGWKVYRVTVGDDSSKLSSVMNKLQLSTWKGKVGHSSVVDIPVPPLQTLQFESGIQGYSSLVMHEDLGASIAQEEIFETYASDFSIAAAAPPSATWFNAYHTIAEHTQWLKDLAAAYPSNTEIISAGKSLQGRDIQGIHIWGSGGKGSQKGVVWHGTVHAREWITTMTVEYAAYQLLTSTNADDASYKNKYDFYIFPIVNPDGFAYTQTNDRMWRKNRKTITTSSCVGTDINRNWPNHWSNAAGASTNPCAEDYKGQAQGDTVENKALRAQLDSVASSAQGAILYMDIHSYSQLWMYPYGYTCSGAVPNSASYASLAKGAVAALKAVHGTTFTAGPICSTIYQVSGSSVDYALENAGSNKGVKYSMTVELRDTGANGFVLPAAQIKPSGEETWAGLAYLLKNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8W1</accession>
    <name>A0A9P4P8W1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_457410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8W1"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2440574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="262" mass="29292" checksum="3178F103E20EBD7A" modified="2023-09-13" version="1">MGRGPKKHQKRLSAPSHWLLDKLSGAYAPKASPGPHKLRDSLPLVIFLRNRLKYALNAREVKSILMQRLVKVDGKVRTDSTFPAGLMDVITIDKTGENFRLVFDTKGRYTVHRITGEEAAYKLGKVKRVQLGRGGIPYCVTHDARTIRYPDPAIKVNDTVKIDLATGKITDFIKFDTAVIVMITGGHNMGRVGVVTHRERHDGGFNIVHVKDAVDNEFTTRESNVFVIGREKPWISLPKGKGVKLSIAEERDRRRAQALAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P934</accession>
    <name>A0A9P4P934_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SCO1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_458398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P934"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="143"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="181"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2438731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="320" mass="35490" checksum="9F0C044A33CB03D0" modified="2023-09-13" version="1">MSSTCNCIAGAARAIKVASPIHLPVQSAAARRTFATINSSRASIPSRAIVGNSAQCTFKAEQNALEGARRTNGAQGQLRTFSSSSPRHALKTIQQVRARNKSGPFNLTAAILFVATASGLYAYFTYEKERVARQRIANQTKGVGKPKVGGSFDLVDHNGNQFTHEDLLGRYALVYFGFSHCPDICPDELDKMALMYDKVKEQCGDVMVPLMITCDPARDTPEVLKEYLAEFHPAILGLTGTYENVKQTCKEYRVYFSTPSTVKPGQDYLVDHSIYFYLMDPEGDFVEAIGRNFTADQAARVISDHIKDWEKPLKKKDRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9C6</accession>
    <name>A0A9P4P9C6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alkaline phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_435560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9C6"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF72">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040123605" description="alkaline phosphatase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2440800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="660" mass="72513" checksum="B1EA5D58CF58F1E6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9G1</accession>
    <name>A0A9P4P9G1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_422933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9G1"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="31"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="288" mass="32026" checksum="964BDEFC7C00928C" modified="2023-09-13" version="1">MARQPGSVELYLPYARVGVRVTRYLQLQTGVEIIYMASITFPKIALVTLYLRIFLGRITRALAWIIIGVLVMFFISGLILALALCRPYAFKWNKTINGTCGDILAGYRWISIPSIITDVFILIIPIPTIWKLQLNKLKKTGIFITFLVGGLGVTTAIVRCTTFYQSDLFSDPTFLACSTMTWTVIEPSAYFICACLPRLRLVCKWLFEKTGLVHVITSTFGTMFSENVSSKGTLVQGGRNAKPANRGFGSNGSDDVVGFMQLDELQIDHHKSRSVHDHVLRSGSSGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9X2</accession>
    <name>A0A9P4P9X2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_436171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9X2"/>
    <dbReference type="OrthoDB" id="3785564at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="272" mass="29954" checksum="B93AAFA77CBCA68E" modified="2023-09-13" version="1">MHKFTLHTIAISISSLTLLALSTALLALESRVQDAFSNNARQYPGSNMAEFIFVPLNPSNIDAWPTVVKFAVGACSLLVSLLGLVWLGLHWWASIVHIRMLGSAVCIATVTNTAATIGFTVYLFTSEAQGRLPKLFRKWGEETFTREFYLCKAVPSIFPDTNAVYGFPACEKARAGRYLMLVICCVSAILAGFSVLQAHQDGVFAVFVKDRSRGGPDVERGRPKATKVDLPQPPETVHMPSEPPLPKYGSLQNVSPRKSQYRTSLYGYYTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBY7</accession>
    <name>A0A9P4PBY7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_393844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBY7"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2441027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="725" mass="81768" checksum="9841BFD80FFC53D8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBZ2</accession>
    <name>A0A9P4PBZ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_98355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBZ2"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000065">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="97"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="192"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2440294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="46383" checksum="7965A719E00BDA8C" modified="2023-09-13" version="1">MAFRQPLSRYGQCNSYFVETQDDGLYAARAEERDRARAIARMQQRALAEELSRLTADEYQEDIMDHMEYMESQTLPDVNSIDIQTEIQWFMRPYLLDFLVEAHAAFQLLPETLFLAVNLLDRYCSRRVVYKRHYQLVGCAALLIAAKYGDKKDRVPTIRELKSMCCSLYDDEMFTQMEWHVLQTLNWIVGHPTVDAFLQVALAEGPYDSEVEHMSLYIAEIALFHKEFVSTRPSILARSSLALARCILSRSDHKVSEWAATYDPQTVMSLSNHLYQPSQVLSRKYSSMHLSNVSTTVDEFLQRQAQIARRAAAPPTPPASVGLEEPKSMSDAYGPQTPQKTHYSASVMQHGCLTPPITPENDQYVAKSHPMPPTTYPTTPTPDHPANMHQAQYYQHTYLQPQPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC45</accession>
    <name>A0A9P4PC45_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P171DRAFT_364931</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC45"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="60"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="241"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2442270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="402" mass="45151" checksum="BC6C3A3B66116B6E" modified="2023-09-13" version="1">MADKGLEDVPEGQIESNYDETTDSFDAMNLKAELLRGVYAYGFERPSAIQQRAIMPVIKATDVHAGHDVIAQAQSGTGKTATFSISVLQKLDPNIKACQALILAPTRELAQQIQKVVVAIGDFMNVECHACIGGTSVRDDMKALQDGPQVVVGTPGRVQDMITRRVLKTDHMKMFVLDEADEMLSRGFTEQIYDIFQLLPQSTQVVLLSATMPQDVLEVTTKFMRDPVRILVKKDELTLEGIKQFYIAVEKEDWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLTARDFTVSAMHGDMDQGQRDVIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTADDVRMMREIEQFYSTQIEEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCU2</accession>
    <name>A0A9P4PCU2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_434296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCU2"/>
    <dbReference type="OrthoDB" id="5426707at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="125" mass="13446" checksum="65AA884400FC27E7" modified="2023-09-13" version="1">MPLTSTRRTHATAPRTTRTTRTKPSLKTRLMGPPRTTATRTSARRAPATTTTTTTTKTTRTTNGAGVGHHGATTTAHHKRHATVGDKVSGALMKLRGSLTHRPGLKAAGTRRMHGTDGRNARRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDJ2</accession>
    <name>A0A9P4PDJ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_81439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDJ2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="217" mass="23916" checksum="D159250B6E65867A" modified="2023-09-13" version="1">MPLGSLSSELASGRGMPWLCKRPFRLLETRDARLEISKAKQSKAKQSMATTSARGQPPRLGDVQVDAVQRDAGREYCLPHSGRAEQQAALVGELEQASRQSGWHGCNEKAFARTTPGRQDDRYLDSRDWRLHTTDAQWGGNGAAAELANVWPCMNSEQRPPAQRALSIPVGRRLLADRPARTLHASWGAADGTTTDCATTGRHDKSSRRRGDVASWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDJ3</accession>
    <name>A0A9P4PDJ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_365579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDJ3"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050068">
        <property type="entry name" value="MurA_subfamily"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="674" mass="74334" checksum="D82A515A76AC277F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDV2</accession>
    <name>A0A9P4PDV2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_392032</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDV2"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2442291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="574" mass="64025" checksum="EB650820DF311AE8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE65</accession>
    <name>A0A9P4PE65_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_330898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE65"/>
    <dbReference type="OrthoDB" id="3764549at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2442227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="270" mass="31228" checksum="651E3A51CAF74F4C" modified="2023-09-13" version="1" fragment="single">MSVLSMLSTIWRLVVRFRVSPCMGCSDWLMLAGTAMSFVCNIPFIILGVHAGVGRLMSDPFWTSHRIHTAIHFQFISICLQMNAMFLVKLSVCTYLLALNFSRRFRAIMWLVTLIVVMFNLIMPLLFHFWSCRPYYFRWHPEIVPECWPEMVGTVAEYAQIVSNICTDLIYASAPLVYLRQAKLTKQMRFKVRLMFLLALVGTASSVVKMYVLHRWLRSSEPFYDIADLSIWGINEISICIVVANLPMQRRSICRTVAFVVPNRLHSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE73</accession>
    <name>A0A9P4PE73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_523192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE73"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="157"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2442365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="314" mass="35605" checksum="3BEC8A43E3DB9383" modified="2023-09-13" version="1">MVEAADIAIVSFDRFVHGSDLDRQAVAKEVYDAFSSVGWVYISDHGVSRVDEVFGLAKSFFDLPIEEKLRWRLRDAEVNQGYTADGDEANGGVDHKECYEHRRFANPHCPSSNELPNFKETLDDFYGQCLTLALNVLKCLAMAMDLGDNFFDNITKKADPQLRLIHYPSIERKIVKQEGHARIIPHTDFGLCTLLFQDDVGGLEVDPFHTGDFKPAIPKRGTVLINIADLLQRLTNDRCRSTIHRVVSPRVAGDILPSRYSIPFFIHPDPEVLIDPIVKEEGEVKKYEPVNAGEWRTWNTKRNYTTLRESIATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEE2</accession>
    <name>A0A9P4PEE2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_392868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEE2"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000024">
        <property type="entry name" value="MIP aquaporin (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2441524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="387" mass="41522" checksum="440A6548157B2C2B" modified="2023-09-13" version="1">MAITLLPLHKKDGGPPRRANGHIPNARNRPSSTSKAQQKASAWGIPNKWRNELVAAAAEFAGTFMFLFFAFGGTQVANSAATASNSSTAGGSDNSITQTPDTSILLYISLIFGFSLMVNVWVFFRVSGGLFNPAVTLGLYMVGALTGTRAVLCFISQMLAGMCAAGVISAILPGPLNVSTTLGTGTSIAQGVFLEMFLTALLVFTIFMLAAEKHKSTFLAPIGIGLALFVAELVGVFYTGGSLNPTRSFGPCVVTGSFPGYHYIYWFGPFMGTMLAYGMYKIVKSVEYETVNPGQDFDDHEAALFNPPDNPESKEQVERPNPAAIAAQEAVRVASQSSGQHSQDFEGIEGRVSQEYHPGYENRQQSRSLERPDEPHFGRNGHAGHMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEE7</accession>
    <name>A0A9P4PEE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_393055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEE7"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="130" mass="15214" checksum="058C8BA3EDC24EF4" modified="2023-09-13" version="1" fragment="single">MYAGHGPNKYFAVNDGQHLLHCLDELRKFAFYSHYYAPRYGPEGNLPKMVAAHRSHCVGVLLDALTCQPSLNMVVWEYVEGQSTPWPDFDAWRMCYGHERFYAWQREVQVGVEMSKTWDWTKGRVKERPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEK8</accession>
    <name>A0A9P4PEK8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_446570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEK8"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF37">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="318"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="605" mass="68563" checksum="97783EF6EEB140C3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF31</accession>
    <name>A0A9P4PF31_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial folate transporter-like protein/carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_434475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF31"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="52"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="155"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="264"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2441869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="402" mass="44702" checksum="BE26F7122524A05A" modified="2023-09-13" version="1">MSADDPTPPSPNRARDRYAPPTALSPRDRPAMHEQNRSSPYSSLARQCAALPNSSVNAVCGAAAGIASGIVTCPLDVIKTRLQAQGSWRPRHQARATRVVYQGLLGTARVIWSQDGVRGMYRGLGPMLLGYVPTWAVYMSVYDWSKDFFYTRMENKWLSRVSASVAAGACSTLATNPIWVIKTRLMSQVSARASEEHRPPWHYKNTYDAFRKMYANEGMRAFYSGLTPALLGLTHVAIQFPLYEFFKMKFTGLEMGQTTSTDSNMHLAGILGATILSKICATSATYPHEVLRTRLQTQQRTMPSASHEDVAFRGSHQEARYLTRGPGTASSDGMINIPRYRGMLRTCATILQEEGWRAFYNGMGTNMVRAVPAAVTTMMTYETLRSMHQKLKQEGLEMQAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFE2</accession>
    <name>A0A9P4PFE2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_474275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFE2"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2442967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="130" mass="14806" checksum="D9F1028511A7B388" modified="2023-09-13" version="1">MVKTSVLNDALNAINNAEKSGKRQVLIRPSSKVIIKFLTVMQKHGYIGEFEEVDDHRNGKIVIQLNGRINKTGVISPRYNVQLRDLEKWVVKLLPSRQFGYIVLTTSAGIMDHEEARRKHVAGKILGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFH8</accession>
    <name>A0A9P4PFH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_433749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFH8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="67" mass="7334" checksum="A1012DC61C2E817B" modified="2023-09-13" version="1">MPHGPGLHRTHVARQHSQIAVACAGIPLNWAVFYTGVRASGQRSFTHTVDQVPINGPTCDSRQRMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGU0</accession>
    <name>A0A9P4PGU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ser/Thr protein phosphatase superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_433424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGU0"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32703" checksum="CB3909348C57C8D4" modified="2023-09-13" version="1">MKRLSGLFSAPKTTFQILSDLYLNYESQYLTFHIPVSASYLILAGNVGQLADYDAYLSFLVRRCNLYEKVFLVLGALEFQGLSHAEGLQLAHHMGEEAATRGRLQILHRTRVDVHNTDITLLGCTLWSNISESAEAAVIKKAPEFDTKEGIRQWTVFDHNEEHFRDLAWLQAEISNPRLFAGTEPSSSASSRLVIVSSFTPDLHHTLPPWQVHSPWCAAYGTDLLNGTEWNGVKYWVHGATGRTGKAKRFGLKIVSNQRGRVGEEEKGILEDGVSEKDKVDLFDVMKIIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGV2</accession>
    <name>A0A9P4PGV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGV2"/>
    <dbReference type="OrthoDB" id="3792666at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="517" mass="57403" checksum="F7CA0FC9CAEF514A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH77</accession>
    <name>A0A9P4PH77_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_25731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH77"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040481261" evidence="1">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="184" mass="19337" checksum="DFF8D9903F7B1B92" modified="2023-09-13" version="1">MFSRNFFSAIALQTLVSTASAGIAIINNHCGYDVAVLSTLTNAQTPIPAGGSWSEGLQGHQSLKIAKDPNLMWAHGITQFEYTVADRLWYDISLIDCVNFGADGGVDGANCAGYDAGIRLEATGGNCAVASLPPNTHDPTQAYFVWNDDLSTKSCQPGEIAGDITMTLCAGGGAKRSVAGRIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH94</accession>
    <name>A0A9P4PH94_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_53124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH94"/>
    <dbReference type="OrthoDB" id="3797690at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="215" mass="24025" checksum="F571A76DAC5385A8" modified="2023-09-13" version="1">MDQTVVTTNMRRVIDNVGKELANVELMFDKAVLPANIAAASIFPAGADLEKEWTAYIKTHLTTISTKAQTWANTQITHALTELKKEITVLEMTMKKLQALEKKATPAYKKNKQTAVKRLTTQIVKHKREVAVITKKIVLLEKQRKAAPSSALTKQIKAQKKAWQRKVEAQAGVERQRAMLYSTSVKKIIAGLKADEIILKAYKANVKSDLVMPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHS5</accession>
    <name>A0A9P4PHS5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_432249</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHS5"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="292"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2444177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="790" mass="89061" checksum="AAF0F3B2CF782698" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIA0</accession>
    <name>A0A9P4PIA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIA0"/>
    <dbReference type="OrthoDB" id="3784856at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="637" mass="71779" checksum="10BAEFF44EAC712E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIB1</accession>
    <name>A0A9P4PIB1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_414881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIB1"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001196">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_1G12380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="381" mass="42430" checksum="A8F985435BC7821A" modified="2023-09-13" version="1">MSQSNDPGHFFQTDAWHSETARRAAKSKNDKGNPVKLPSKILAVAADPHDDSLIYVAEAAGTVKRINPEVEKKVVATYTGPEAPLTSLAISHKSGKLFAGCWDKTIWSWDVKSRRPGQRFRGHADFVKTVLVFTLQGRELLLSGSQDATIIVWDAVTGQRLYTLKGHTRGILALALDPLEYDPAKEEAIVFSAGSDREIRRWRVGVSAGKEIKEEPFPILAHETSVDLIHFDSDGDLWTASADKTAKCLSRARNWEEDSSFEHPDYTRDVAVDEDGGWVVTACRDENVRVFEKGSGKLHHVFEGHFEEVTALVLLRQRVISVSIDGSVRTWSLKAQELAKAIQEAEDEKEGKVEEKVEEKKEGLLTLEEEEELAALLEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIE4</accession>
    <name>A0A9P4PIE4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIE4"/>
    <dbReference type="OrthoDB" id="3787418at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="435" mass="48339" checksum="938F6D90D39E4085" modified="2023-09-13" version="1">MPPKRKRVEPKEHEDEHRTPTYASEVEWLACLTDPSREVVVNEEVADGKTNTALITEACKLTYILYHNIQAQDCLPAILQSLNKSGTEDDAELTRVVKSTQSAWKAHVVNKFLLPHVKEIVRKWCVAHPYANFGSLPMSERVKMWFEAYDADPKGIVTLMWKPLIKVLDLASIFRTDLPSEDNAKAKAVRQMLRQKYFFGCECTYKYSVADQKKASSGKTLEDWALYAEFGDYASSIVPFADLLVSPKLLALASSESPAKKTKVALAEDFLESASLSSTFDRSDAATVASATSDLISGERHKMGELSSFLSSLSNSRTTSVAPTPPVIEKQEEYTEPSPSLHHLIKRPSPDTGLKRQSGQKSSSLDEFFARKDRLPVFLSAPIPTPPPAAPMNEEDRRFNEFFGIPIEASLTSTMASEDSSSEVAPEPELDEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIU4</accession>
    <name>A0A9P4PIU4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_495500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIU4"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="64"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="336" mass="38265" checksum="8C0DF7D4F2A7C875" modified="2023-09-13" version="1">MSLFVPNRKQNFSRSNHVREPRQSRHTSKRLQRNIKHIKLSGIDYFEAVAQDPADVPPPPDGVGEYKCDYCQEDFLINHDLISCCQDGIATCAAHFLCNACISAVFKQALTPGWRYFPARCCPSQDSRRGIDIDCCLSALYSDNWGRDKIRAYKSKAEEYSVMTLTPDLYVHCAKCGIWLHPCCIKDLGISAISKYQVAICRPCGTKTCMECKSEWEGFFHRCNGSEDPSVKPDWLPDYAPDCRIKPCPRCRTWIQLYDACNHMTCENCYYQFCFVCMMKWSDVPHGCPLYGDPAGGYDAEGYGLDGWGLHVYTGLDRSGRNRISILEQRGSRQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK72</accession>
    <name>A0A9P4PK72_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_266390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK72"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="61858" checksum="367BF515F4F9F00F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKB9</accession>
    <name>A0A9P4PKB9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_512471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKB9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="501" mass="57179" checksum="4357FC8ED2365B88" modified="2023-09-13" version="1">MVISYDTAQSVVATGLAVYLAYSLCVAVYNVTLHPLAKYPGPRLACAFKFPYLWSLLKGSATHETKLLHDKYGGVVRVAPDRLSYNTAQAFRDIHGTRPGKKQLPKDEEWFVDHKEPVNIIKSNDADHARIRKLVAHAFSETALREQESLLMGHTSNLMNKLSQIVDGPEEGRVDMMDYYNFLTFDVIGDLCLGESFGAVDSGEYDTWITQIFQGLKFWRVLRIGNAYPLIGFFLRIVMAAVPSVEAMRDSFFKIPKAKVDKRLATKTDRKDFMSYILRYNDERGMNHTEVIDTATILIVGGSETTATLLCGLTYYLLTTPHVLRRLQAEILDAFATEDDMNLRTVSRLPYLDVVVQEALRMYPPASSTFPRRTPREGEVIDGHFVPGNISVGVHHYATYHSAKNFRNPDKFAPERWLDDGHAEYRTDDRSAFQPFHLGPRNCIGKNLAYFEIKITIARLLWDFEPVLCEESKGWLRQNVFLVWEKGPLWLRLRHRKSDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKS1</accession>
    <name>A0A9P4PKS1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_443417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKS1"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="524" mass="57954" checksum="FFA092964EC67E74" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKZ6</accession>
    <name>A0A9P4PKZ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_243306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKZ6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="236" mass="26404" checksum="44DBA38FC37CE0A5" modified="2023-09-13" version="1">MLRYKCGVPRSQKSITRPVASEWIRLLQMRLPCMRCPRNVRSWNTSPCLTSLCANPMWSSSMTTRLSSSAPALGPAASVLCVASPAPARSAFRIALGPALSFWSAFVWIHLFLSILIPNLASIRLSDRMRVLRTRSAIRHLLTSKRLGDKRQYIGEGSQGLRCDLWAVRTLSVGYAHQTTLWMERRLQLPTNAVVLPTSKVGRTTDLLWYARRTITVVDAFLLHADHDCRAPSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL39</accession>
    <name>A0A9P4PL39_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endoglucanase EG-II</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_511244</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Endoglucanase (EG) that cleaves the internal beta-1,4-glucosidic bonds in cellulose. The degradation of cellulose involves an interplay between different cellulolytic enzymes. Hydrolysis starts with EGs, which cut internal glycosidic linkages to reduce the polymerization degree of the substrate and creates new chain ends for exocellobiohydrolases (CBHs). The CBH release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain. Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL39"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000124">
        <property type="entry name" value="Exported cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF5">
        <property type="entry name" value="CBM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040383771" description="Endoglucanase EG-II" evidence="14">
        <location>
            <begin position="24"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="15">
        <location>
            <begin position="63"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2447084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="352" mass="37324" checksum="F5A5B4F053280D7C" modified="2023-09-13" version="1">MKASLLTLTSLATFAASSPTLRATKVQYAGINIAGFDFGCTIDGTCSLTGTNKPYDVVSGANAVGQMNHFVKDDSLNAFRLPVGWQFLVNGQLGGQLNSNNAGQYDRLVQGCLNSGAALCILDIHNYARWNGAIVGQGGPSNAQLADVWKQLATKYGKQSKIAFGVMNEPHDIPDIKAWAATVQAVVTAIRAGASNHLILLPGNGFTSAESFVSSGSAAALDAVTNPDGSKNNLIMDVHKYLDSDNSGTHTECVKDNISNAFQPLADWLRTNKRQAILTETGGGNTQSCQKYMCSQIKYLNQNADVYIGYTGWAAGGFASSYELNETPTQNGNSWTDTSLVKSCIVGAWKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMG9</accession>
    <name>A0A9P4PMG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_520289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMG9"/>
    <dbReference type="OrthoDB" id="3945550at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="645" mass="74391" checksum="0F6B9D534F44BB23" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMP8</accession>
    <name>A0A9P4PMP8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_243862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMP8"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="50"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="17936" checksum="00A04ED014EEF4D3" modified="2023-09-13" version="1">MLRIKEPKYTLPQLCYNRLQVPLCRRRRVSMSAADVVKLVPFDASNAQTYDALCHCGAVQYAVTLSPPLAQQKIIECNCSICSRNGYLLVYPQREQVQITSGQEALKTYTFGPKRNLHHFCGRCGSAVFFDPQLRKRGEDHDIMGVNVGLELAKDSPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMR4</accession>
    <name>A0A9P4PMR4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_431150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMR4"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="9">
        <location>
            <begin position="54"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="335"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2445754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="501" mass="55406" checksum="0B2CAD4BE12A2A46" modified="2023-09-13" version="1">MSAETITSLLSFQPDAPELQQKREYDKEAREFVKQVNGLTPATFLKGADSPQDPLNVLDPTTNAIAYAFTLRHRIEAATKKSVDQLRPGGSLWNKLVLFLESFDPVQMRYAGEQWRKLVEYVELIARNEGAPALAIAPIRSAMFRLDPTTGTFTSTHLHFIHLCMETRSYKAALPVLSNYIHSLPTAIAKETLEDLEYSVAAADSVASGEFINLKSGHTAKISLADLQEYYVLGAMAYLGERQVHDALHFLEHVLVTPANNALNGLMLEAYKKWVLISCLADKSHKTPPRTMSSTAVKHCKNAAKAYEALAEAFQQVNNLPKLKAQVNAGSDIWAEDGNTGLVEELLEHQNRAYLSRLSRTYSAIPVSNIARNVGSSVDQVTTFVDSLIRQGLLNAHLEANDKSVAGAVLRFYLDPTQGPLAKTEKQQQQALFERTQRTNALAEQVKDADYRLSITKEYVEYLKRQKKKNGASGGGGAGVDVMDMGFEDGDLDEDIMGDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMS6</accession>
    <name>A0A9P4PMS6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_510939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMS6"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="89" mass="9609" checksum="9B1EE8877AAA9087" modified="2023-09-13" version="1">MRDKSLINIVFATQLADETWSKSMEHGESLRSAMKGVFVPPTQVNFNILKPVPGVGAVGVHCTLVERKDNTMGINAVMKDGQGTPLVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMW2</accession>
    <name>A0A9P4PMW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_519250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMW2"/>
    <dbReference type="OrthoDB" id="9984533at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF10">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="300" mass="32463" checksum="38456E4009B5C680" modified="2023-09-13" version="1">MSIKNVVIIGAGGNLGPSVLDAFLKSSSFNVTVLSREGSDKTFPDNVKVVRANFDSFDSLKSAFQGQDAIVSLIASHVLASQTQLIDAAIAAGVKRYIPSDFGSNTADPRTLEAVPLFKSKTDVQDYLKSKENEISRTIIVTGPFFDWGLKTGFLGVNAQTKTVGLVDQGTATFSTTNLRQIGIATVKALERAEETKNKFVYVSSFETSQKELLEKAEKLTGEKYKVEHLESKQLREDGLNKVKAGDFSGFVPLLQAAVAGKAGLGDHRPFGLWNEKLGLEKEDFDESIKAGLSGKNYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN70</accession>
    <name>A0A9P4PN70_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN70"/>
    <dbReference type="OrthoDB" id="4157427at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040432971" evidence="1">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="121" mass="12960" checksum="E2DCAE6F04221416" modified="2023-09-13" version="1">MGSTYGSQTRISLGLALVFTFIVGSQGSSLATFSDEKCLNSLEGIDGPNGYPNGTCTPLDIKGPAWKSFQIVGLDHGCTREEYPTIHANPARQQLWSSHTSPLATTDRGYTTASTSAIYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PND4</accession>
    <name>A0A9P4PND4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_483784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PND4"/>
    <dbReference type="OrthoDB" id="3796055at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040261438" evidence="2">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="101" mass="11936" checksum="47F8755210B83EBC" modified="2023-09-13" version="1">MAIVTLIFLPATAVATMFSTSFRNWMPDHEAKKNDSVVSRWIWIYFLCSIILSLAVYFLTYIMHRRERERRNRRLALDRRPSTAPSKRLRTLSTKDFGLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNY0</accession>
    <name>A0A9P4PNY0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_472072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNY0"/>
    <dbReference type="OrthoDB" id="3736964at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="53923" checksum="439502E5C9A97FA3" modified="2023-09-13" version="1">MMSWLAPKRASTKELCDIYPSRRHVERTLLQHLYPAGIPTPTLVRFSGYTSEGGHDISWTASTCSSFLASRLPSASEVATAAGPVLYRILLHHGAWPFKPAPEPDAPLTAERFAIAAALLMAEDRGTITFQDPQTHSHMVHERPRDWGNRCRLLFQSLCNTDWTARSTQDGSARTAADDEDLVAVLCACMPQPQKMDRARFVPVAATLPSSHSRALDGRVDITSIRALLGLLLSLPAEDAPASSAEETGGSRTAVGAVVGAFAPQDGDADGDVDWERFRSVMAQSTPLLLTELAAFISAQFPGPRRGGGLLQVQHPRTIPPAMVATSPSSTRSSLTLPQLRQLSLVLPHPLLSTFSLLHQSPPSHTTTATIARLLAAPSSRLLLIRGGTTSGPYALAACVSPGTTQDADATKTHFARTPLSPPAPGSAWNHPFSSPSTGPVDCFVRIAPTHGVFRGSFGSARVDTCGADGLSVHLGGASMWFEGGLARGTVAGEGESVGFVVGLVEVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPJ4</accession>
    <name>A0A9P4PPJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_355597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPJ4"/>
    <dbReference type="OrthoDB" id="5230947at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="71" mass="7539" checksum="3959270817B011B3" modified="2023-09-13" version="1">MGAVLSCIKSIFRTIGNVLMTIVHAIGAVCTAIINGIVALFDIIISCLTCGRGGSRRRGVKTRTTHHTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPR4</accession>
    <name>A0A9P4PPR4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_518466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPR4"/>
    <dbReference type="OrthoDB" id="3799754at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="582" mass="67844" checksum="970C029EF7BCB955" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ44</accession>
    <name>A0A9P4PQ44_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_241916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ44"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="234" mass="25704" checksum="4C1C833C367D9436" modified="2023-09-13" version="1">MKMHAELSGKLRAARKTLQDEQAALQKEREAHLCTLTVQEALIDEAARHATKEATETARRYVRGQKDRIQNARGGSIGTPLKLDEEAEMSAARENNECTATALAKHIMEDSMEEKRECKRVAPDLSSLVGLGSQSESPKSMQKSHQGSEMFSKRLDAAFGQTQNHHRLFNSSDIAGFDGSKGEEGPLRRVAGTSSPVSGLNSSAPPYSLRHRRPNNRYVAFSAVTRRRSGKSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQK3</accession>
    <name>A0A9P4PQK3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_429093</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQK3"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="343"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="12">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2447453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="505" mass="56997" checksum="1F167DEFADD2C1BD" modified="2023-09-13" version="1">MPSMVVIPTTGGPATRRVRVDKVHSIISNRIKDGEEQFLVRWNSDTTAPPLSWHSIRELARCLEVVQDYITSRENAKAPSRKRKSPDIGLEHERRASPYDRRLSLEIRTPSASRSPSISSVSTAPTVDVYNGALDTDENGFIFCRSAHGQGIAFLDVQSLPTDDMLRVARTSKIETANILIRAEYIRRLSKVVGKKIHLVNVHDYTTPSLRFQYVPEYVLREGVFRADLATQEGCQKCSPHMGRDIGCEYTKKCGCLEYAAVDVSRITTAEMKQEYDVALATGGSTLGFPKKFPYFTHGTKRQRTGTLVPFYLDSRHPIYECNDNCRCGPYCRNKNVQFGRQVELEIFKTGSGRGWGLHCKEDLFMGQFVDTYRGEVITDAEATRREQAGGMMKASYLYSLDKHQESEGLAQEDIYVVDGEFMGGPSKFMNHSCEPNCRQYTVSYNKHDNRIYDLAFFAIRDIPAGEELTFDYLDKEEADEEGDAPAGAVPCLCGAAKCRKWLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQL8</accession>
    <name>A0A9P4PQL8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_381341</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQL8"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="67"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="222"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="533"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="765"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="794"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2448606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="868" mass="99615" checksum="ED276357DCD1E9C8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRR0</accession>
    <name>A0A9P4PRR0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_222174</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRR0"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000005">
        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="33"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="190"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2448962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="299" mass="33111" checksum="26681834D8C2FE07" modified="2023-09-13" version="1">MPQEAQISINERAFIQDALKEQLRLDGRAFDAFRALELTFGDEYGVADVQLGKTRVIARISVDVVTPAPERKFDGVFQIITEFSPMASPAFEVGRPTNAEVVLSRILEKAIRRSNALDTESLCIIAGLKCFALRADVHIIDHDGGLIDASCIAVMAALQHFRRPDVVVEGEKATVLSIRERDPIPLSILHQPLCVTFSYFEEGELFLVDANLAEEQVRNGEVIITMNRHGEVCQIAKYGGATVEPYALFNLTNLALQKVKEMSKFIQTQLDEDAKKRNAGGLLAELSAENDRPFDRPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS68</accession>
    <name>A0A9P4PS68_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_426753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS68"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="33"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="404" mass="43941" checksum="DDCE6B61ACE4EF93" modified="2023-09-13" version="1">MASQRAMHNACTRRFLRRGFSTTTRRDADFTHAIIGGGVVGLAIARQLQGREGASTVLIEKHGTVGTETSSRNSEVIHAGLYYGPDSQKTPLCIKGKSMLYELCARHSIPHRNTGKWIVAQDDTQFKALKSIHEFSKQVGVPTRFLSKEEAQRREPDVRAEAGVLESTSTGIVDSHSLMQFLEGDLENRGGICAFKSPVVHVNPLDAGRGGWEVTTKTPDGEESTITAETLVNSAGLAAIPISNMILPPDRHRKPFYAKGTYYSYAVSRPKPSTLVYPAPVPGHGGLGTHLTLDMAGRIRFGPDVEWTDDPSDYTPNRANLRAALDDIQSYLPGIDREAIDLDYVGIRPKLGKASATSGGKGFVDFWIAKEDGFEGFVNLLGIESPGLTSCLAIAEKVEALLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS73</accession>
    <name>A0A9P4PS73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_480389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS73"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="66" mass="7253" checksum="5C70A9F93121DD6E" modified="2023-09-13" version="1">MAPSAPPQPPGFIVIGTLSSNVTSWTDRRENKRKDEMETGDREAVGGNGNALLDLSDENKQFMYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSC2</accession>
    <name>A0A9P4PSC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_235584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSC2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="165" mass="19006" checksum="5A0909FA01428467" modified="2023-09-13" version="1">MAFHSPARMLRRAWCGSDARCKHGTTAEMEHRHREGLVDPLSGRDESWDGSSLALTSRVHTRQRGRTGRLSTHGRRTERVGREPGTAESYDCRRAATMHSSIGRRLQWQRPRLARGKKEMRLEWAPRLAGRGGDRRSLWPWTMRRDVQAGIRTYRATGVSITFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSF6</accession>
    <name>A0A9P4PSF6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_427608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSF6"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000053">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="430"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1014"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="747"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="828"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1206"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="831"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="970"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1228"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1238" mass="137450" checksum="88BDBA7F961CE44D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSG1</accession>
    <name>A0A9P4PSG1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_461333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSG1"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="454" mass="49783" checksum="C6CF111A09542F26" modified="2023-09-13" version="1">MQGSSMEQILPVPSPVSSYWLSQPHKFSNLRSSTELPTECEIGIIGSGMAGITTAYHLFKQENPPTSVVILEARELCSGATARNGGHSKIKLSTLASQVQKLGADRVDELQNFVQGVIASLKQVAEDEELDCELEIRRSFDVQLDDEDAASLKDIYQASRKAGHTWTNNVDFALPQYLEQVTSIKGAKAAESVPCCSLWPYKFVTQLLERLVSRHPEQLNVQTTTPVTAVSVLADGTNAITTPRGVLKAKKLVFATNAYTAGLLPQFKDVIIPVRGMASHIVPKVPVHPHLSHTYNITFSSGQSADYLNPRPDGSIVVGGGGSMFKSDRPSWFDNFDDSTRFSGEVEKYWDNYMQRVFLGWENSEAVVEKVWTGIMGSTPDGWAHMGRVPGRHSQWVLAGFNGGGMALIPTGAKAVAKMVAEDSDFVDVKREFGIPEIFATSTERLREAFAETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSN8</accession>
    <name>A0A9P4PSN8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_142958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSN8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="181" mass="20359" checksum="D190C777AB52A4EB" modified="2023-09-13" version="1">MASTPPNTATRITKLLQTITKLHHENALTMQAQLARNPHPQKLYMTVIRTSRSSAKPSLGDMLISDLTQAPTTLTDATGNFFVKNISERENFHFVLTWDKYPEGAPGQLHVIDMAVDRDDAERMFKAGVAGFDGWMEEGGDGIWLDERRVRKRVYRTTGGLWVWVELVEGGVGHRRVVVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSQ5</accession>
    <name>A0A9P4PSQ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_348310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSQ5"/>
    <dbReference type="OrthoDB" id="2519291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2450654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="132" mass="15246" checksum="DF445E854774F04D" modified="2023-09-13" version="1">MTFSAIFFLTRKPSLTLEEFKSVYENKHLPLLQSLFGPAAPLRYRRYYVSQTISDIPVTPASPPPSSQSTIDETSEDPDYDCIAELWWADEKTFHDFNRMYKLPGNLARIAWSEDEFLVRGKLRAIVIGNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT41</accession>
    <name>A0A9P4PT41_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="8">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCS3</name>
        <name evidence="8" type="synonym">FIT2B</name>
        <name evidence="10" type="ORF">P171DRAFT_428039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT41"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2449911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="305" mass="34103" checksum="8094298BB1C2FD80" modified="2023-09-13" version="1">MPSGTIRTTPAARSPFFPTRLEAQLLLIYPATLLLGSVLSTLTPAFRNAPYSPELQSHDPAFAPTYFAKKKNIFNVWFVKKGWGWTTVAFVVFLLMWPGFGKGLSVKRIRAILRYSVITLWWCFVTQWFFGPPLIDRGFLFTGGQCEKLNDPSAMEDMSDTRVYLTAATCKRAGRKWSGGHDISGHVFLLIIGSALLWFETLPAITRFEGLRDGRKIALDDGKVASVTVEKSPESEQDEATRQGVPLPLGVIIFMWWMLLMTAAFFHTWVEKFTGLLVAFAGLWVVYFLPRGIPAARAVLGMPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT97</accession>
    <name>A0A9P4PT97_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_381831</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT97"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="611"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2448878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="708" mass="77761" checksum="86833E7911DB8491" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU37</accession>
    <name>A0A9P4PU37_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BCS1-like ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_219719</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU37"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="16">
        <location>
            <begin position="55"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="290"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2448826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="575" mass="64274" checksum="4890B3E376CE00ED" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV68</accession>
    <name>A0A9P4PV68_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_516772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV68"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="72"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="457" mass="51405" checksum="D9EE321336FBC742" modified="2023-09-13" version="1">MTSDAKELLETKNGGRFGKQLRKEFLFEEGFRNLNHGAFGTYPRAVRDVLRSFQDAQEARTDDFIRYQYPKRNDESRQALSKYLNVPTSELVFVPNATTGVDTVLRNLTFAPNEYILYSASIYGACEKSVAYITETTPAKAAKIEYTFPVEDDWLVSAFASKIDEIEKAGGKVKVAVFDTVVSMPGVRLPFERITQLCREKGVLSLIDGAHGIGHVALDLKALDADFFITNCHKWLHVPRGCAIFHVPLRNQPLIRSTLPTSHGFTPCPTPSFTAPPTPLPSSNAPKSLFELNFEFTATLDTSPYLCVPAALEWRASIGGEDAIMRYCQTLAKHGAKRMAEILGTQVLDNETQTLTRCCMANVALPLDNKRMFEIGTQAGLEEGEVGIAIWNWMGRVWIDDYKTYLQSMFYDGRWWVRMSGQVYLELEDYEWAAGVIKEVCERAEKGEWAEKAKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVU2</accession>
    <name>A0A9P4PVU2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_516113</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVU2"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="170"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="30"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2450168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="339" mass="35923" checksum="BBB12DD93E555537" modified="2023-09-13" version="1">MFSARQIFAQVQRRGFAASARQSSKVTVLGAAGGIGQPLSLLLKLNPRVTKLALYDIRLAPGVAADIGHINTQSEVRGYDATPSGLADALKGAEIVLIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAADHAPEANILIIANPVNSTVPITAEVFKAKGVYNPKRLFGVTTLDVVRASRFISQIKNTDPANENITVVGGHSGATIVPLLSQSGQNLTGEQLDQYVHRVQFGGDEVVQAKDGAGSATLSMAMAGARFAESLLKAAQGQKNVIEPTFVDSPLYKDQGVEYFASNVELGPNGVEKIHPVGKITDHEQKLLDVCLKDLAGNINKGVKFVKENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVV1</accession>
    <name>A0A9P4PVV1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_480793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVV1"/>
    <dbReference type="OrthoDB" id="3792083at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040402452" description="Concanavalin A-like lectin/glucanase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26880" checksum="E98F517FBA4D4284" modified="2023-09-13" version="1">MKFNIALLPALIGLATAAPTPEDQGGPPTWRRDAKAQVGRLTWRRDLEPQRADLPRGSGKRDLNAEADRPVLFRRSPESQNGPPTWKRQYNTGTIRPSFTHVWTATPGLGFFEASSTGYVRFETTETDQTFQPDASLRGQSAIVGFDFNAPRDEIKDGTAFQVFFAQEDLVLEKDKNKSNTNSTRGSHVARFVFENGVPQLPEGESGKFRVPDKTQFTLQVVGSDGAEFEFNAVGGEGLSVTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW41</accession>
    <name>A0A9P4PW41_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_346816</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW41"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="630" mass="69941" checksum="5324C0411DDFCF5B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW43</accession>
    <name>A0A9P4PW43_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">ATP synthase protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_480920</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATPase protein 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW43"/>
    <dbReference type="OrthoDB" id="3916939at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009230">
        <property type="entry name" value="ATP_synth_su8_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36101">
        <property type="entry name" value="ATP SYNTHASE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36101:SF1">
        <property type="entry name" value="ATP SYNTHASE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05933">
        <property type="entry name" value="Fun_ATP-synt_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 15" id="KW-0138">CF(0)</keyword>
    <keyword evidence="8 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2449861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="100" mass="11306" checksum="1D6F16077D213629" modified="2023-09-13" version="1">MNSARLFRPFARAAFRQPAMARASVMARPALASAQSKKTEVAPQQMTILKSAMPQLIPFFFVNETTMAFVLLPTLIYVLSKYILPQRVRLFAARLFISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWH2</accession>
    <name>A0A9P4PWH2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ketose-bisphosphate aldolase class-II family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_451112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWH2"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="entry name" value="Four-carbon acid sugar kinase, nucleotide binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="entry name" value="Putative sugar-binding, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142764">
        <property type="entry name" value="YgbK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Four-carbon acid sugar kinase N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Four-carbon acid sugar kinase nucleotide binding" evidence="9">
        <location>
            <begin position="305"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="51646" checksum="941732273D7156A9" modified="2023-09-13" version="1">MSSPSPLPLKQTLDSLPSLKSSLEETRSQTRAQIQSNARIPVLVALDDDPTGTQTCHDIPVLTTWSVEVLAQELADTKAGSGFFVLTNSRALYRPAARDLMIEICTNLKAASAKAGKPFEIVLRGDSTLRGHFPLEPEAAEEVFGQADAWILAPFFLQGGRYTIDNVHYVAEGDVLVPAGETPFAKDATFGYKSSNLRDWVVEKSKGAIPRERVQGISLSDARSGGADVIAARLMEGARGTVFIVNAAAEEDMDVIVHGILKASAQGKKFLFRSGAAFVSARLGISPIPPISAKQLDLDRTKGGLVIAGSYVPKTTAQLKVLRERSGHKLTTVELDVNKLLQSPESREKELQRALSTAEDELQRPQDVLVMTSRKLITGADEHSSLEIGSTVAAVLVAFLKKLKATPRYIIAKGGITSSDMATKGLGMKRAMIVGQAAAGVPLWRCDEPTSKHPGLPYVVFPGNVGGEETLAEVVERWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWK5</accession>
    <name>A0A9P4PWK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_134973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWK5"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF111">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_1G10100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2450131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="295" mass="31651" checksum="448DDF78B1BF9541" modified="2023-09-13" version="1">MASNATVPTSAPPARHHEGKVAIITGASRSIGASIARNLAAKGSNVVIVYLTESSDPLADKLAAELTSAYDVVAIPVRADFTTTEGVQKIITEAKDKMPVNTKTGKFQVDILVHSAAFFHALPLEACNLEDFQKVYAINVWGPINLTQAVKPYLPTDRSGRIVNISSVGSKVGLQYLTLYGGSKGALEAMTRTWARELAEQATVNCINPGSTMTDMYRNANPAAKEANALFNPLVPLSPLREWDTEEQRRFGEMYGGRVAYPEEIAGIVGMICSPESAWMTGSLISANGGQWMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWR1</accession>
    <name>A0A9P4PWR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_515651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWR1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="263" mass="29982" checksum="09D3E4B6311C350A" modified="2023-09-13" version="1">MSATTVETASLPPLNLTLQNGQKIRYHSDISIEADEIPVIDTYRDDIQARKAVAEKYNRNGKNEKDQMEAYSWGYDPKFNPEVASEVEPDVDYRELLWPKALPGFKETLYQHHSQLLTFARRLTKIFDLALHLDEDYFAEYSKTPAAGMRVTHYPPQEALPSDQLDTGAFTLIQAKPIPGSVVVNIADCSMRHTNAFFVSTVHRVFNNASAERYSCPFFFGFQQDMKLEPVPTCVSNINSMKYPIVSWGEYLEWRAEKAKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXE7</accession>
    <name>A0A9P4PXE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_516441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXE7"/>
    <dbReference type="OrthoDB" id="4106209at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="480" mass="53314" checksum="0FA4695C267304A6" modified="2023-09-13" version="1">MLVEPLSPNPPPSDAALHTHSYLQTCWRRPPWTPKGPENVRLACSSAVEVSVLVQKLAATKSQPRARTAGRLDMDTQGRRRLAARAWIAAKQLTVVTCEPCTQPPLTIELSTTIGPRPPRSLANGQLRTVTPDNTQGWAFGAFFKKREPPPSSLLLLRPVSSSHDQNTAHAVSLPAEPRHHSEWNVAPHIRLHTKPHPESGALSYTTAMHRKTPISVLVYNALFPSPSPNDPPSFSAHLSKNLVGEVRIETATFYGSLDTIEARYPGLNYAHAPHRKRLGRFPHHRKLFDAFNRLSLTDSEIQGFCRWEGTLWARERYERDEGVKVRDTTGVEIGEWVDRRRTTSARRRNGINVKTDIEVEIEEVPSSTEITDPVRPVDTEMHDSSEDDDDGDEQVLDESVGFALNQRLMQAAALREQGQDAPMDPEWEQYLKDAQERGEHSMAEHLGIAPTISGGVAGFTNMSEGPSAPTQPYPPVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4J1</accession>
    <name>A0A9P4U4J1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_315009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4J1"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2438004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="564" mass="61485" checksum="49370FBFD6976663" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5T8</accession>
    <name>A0A9P4U5T8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_167198</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5T8"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="462"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="114"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2438066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="830" mass="94114" checksum="129E61024C4F3882" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5Y1</accession>
    <name>A0A9P4U5Y1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_491208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5Y1"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF156">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="105"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="361" mass="40047" checksum="8BBCA1B9EE835E74" modified="2023-09-13" version="1">MTGTSKFDPAELAKLPAEYLQEDIGHRLLIVASVFIVLQPIFVCLFYVSRHLNKTLDGLECWLFIPMGYMGWCWPSLEAFMLQDPHMLITRSKIVKAVEFIDYEAITRSKLTILSLYLRIFSTRPYQIAAYLIATLIILTAIGAHISSLSICPPIAYQWDPTIPGGHCGNIMLAYQMVCVPNIATDIMMLLLPLPAVFKLRIGLAAKIGLLITFLTGSVGIVTSILRLDTFIHSAELLKDPTYKCIPTFTFVITEGGTYMIAACMPTLRPLKRRLLPNHSVTKLIDLTLSAFSVRTASNFSRRLPHQGGDLRTTPIKLDTSSKASDDLEFQSFSTTRLNDVGHLATTGHVSNVSSIASHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U647</accession>
    <name>A0A9P4U647_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_467125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U647"/>
    <dbReference type="OrthoDB" id="5041285at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040193895" evidence="1">
        <location>
            <begin position="16"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="247" mass="26413" checksum="E0A1E0091A6B0C5E" modified="2023-09-13" version="1">MRLLASSLLFSAAVASPLIERAAKPIYWLLAGDSTTAPAGGWGDGFLSTTVASGSTGHNYGHGGATTASFRAGGDWGKVIKDIGTYKSKYDVYTTIQFGHNDQKETSGVTLDQYKANLLKFAQEVTSAGGQPILLTPLTRRNFQSNGKVLENLATQRNITTQVATSNNIKWIDLNIASVNYVNALGKTAASKYNLASDDWTHLNTWGGVVFARIVSDLLVEKYPSNFQAYTKANATLSALIKAGKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U658</accession>
    <name>A0A9P4U658_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS quinate transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_373003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U658"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2437768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="554" mass="61188" checksum="7796045B7E10EBA7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6J7</accession>
    <name>A0A9P4U6J7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_491374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6J7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="112" mass="11578" checksum="DC007D2C12E3B551" modified="2023-09-13" version="1">MAPIAYNELLDSSGSYITGAIHQLLARIPKGGGGTPTAGAGAPAAAKPKHLHLDPCDKACKIGLGVGIPVAIIVLIVLGSWCAIKGPCGRTGYERNTVITKPQRPRRLPETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6U9</accession>
    <name>A0A9P4U6U9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="4 10">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_436984</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="4 10"/>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6U9"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2438518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="423" mass="47729" checksum="BAC851010753E067" modified="2023-09-13" version="1">MDSEEPQQGLSANENSDATSEAAQESASASPSLHEPRIRCRPISYQDIGETSNSVRFEFLAEGAANAVFRVVPYSSRGGEKSFVFVDDQGNILDKEKLAKKVLRMSKGRPKTLKYEEIMEGFETEVKPLFRKTEPSQERAPGRSTATNLSINESFEEFIMTHEGVAIAPEAIKALIAELHTHCPNNRHIEPHHLEERGILLPDMSSVPGSVTTIEIKPKWLLQSPNAPRDAYRCRTCALQTSRQSEKPYEGPWICPLALVAGNKAAIEPYIRYRSLRTLNERPDKNVMQPPSNDAVEAIVQRAVPYLITGPGHKILQHIRYLQGQLDPEGVLCRPMSSKKEDRLRLAMTLRDCSLFIRIPWADQNAPIDAKLGDLDFKSPGKMRDWFKKEEGLLHGGWYVNLESGMDECWIAQGWKKYVPHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U725</accession>
    <name>A0A9P4U725_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_524722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U725"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="42749" checksum="B883AE64DD81606E" modified="2023-09-13" version="1">MADDDNFDIDIYGDESGPTFQDAAVSQPPKQSNAAAHEDSLEPAMETTEKPTDPDAANKRDSSVTGTNGTAQYDNGTQQISSTGASANNQTFLKQAPQQQGVKRKQGEDDDRPMDPGATAALMINDLNWWISEEDIRGWANQGGCEDELNEVTFNEHKVNGKSKGQVYVQLQSPQAATALKHQIEALYKDQTHTKKPTAIFNPPHVNPFKTLPKDVPQRDKNRGDRSSSGNFGNQGGQGGNFNRFNNQRGNFNNRGGNNVGFQRGGFNGPAGNMGGNMGGFGGPGPMNNFGGGPMGGMNNFGGGNFNRGGMMGGGMRGGMNNRGRGGMGMNNMGGMAMPMGNNMMGMGGGMGMMGGNMGGMMGGGMGAGPGGFGGNQNQFNPGFFQQGQGAGDGNWNPHGAKRPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U735</accession>
    <name>A0A9P4U735_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_436685</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U735"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2438773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="175" mass="19647" checksum="B8FE020800B689F4" modified="2023-09-13" version="1">MALEGCVGSLRSSMQLLDSSINILDEATNDFPRLSKVLHTTRHFELISEPDLHSAQSALLSEIRPEVESLLTRVQNHLDKLERREQSLIAKCDLNDGRLGTQDGNAESAFTPKNRGSAGANGKPISAVQEMKYKQLRAKKQRLSYAVETLELQAKQRERQLRMSMAAPQQFEVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7T4</accession>
    <name>A0A9P4U7T4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7T4"/>
    <dbReference type="OrthoDB" id="2150628at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051667">
        <property type="entry name" value="Archaeal_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096">
        <property type="entry name" value="YALI0E33429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="62223" checksum="D8378EE95C2F0B1C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9K3</accession>
    <name>A0A9P4U9K3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_434836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9K3"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF5">
        <property type="entry name" value="DEPENDENT EPIMERASE_DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="313" mass="34248" checksum="14A94B7B08CC1750" modified="2023-09-13" version="1">MSKQTIFITGGSGYIGAVIIEYAVAQGYSVNALSRSESSDDKLRALGASPVRGDIKSLDVLTREAREADIVINIADAIASDFNISQDERWATNYAAHDALAAGVKGTNKPLIITSGAMNAQPHPNDEETDETSPGWPQGHIYSRGFESNKQTYLDQGIRISYVRLAPYVYGRGGSGVRLYMKSFVPRGAGFFILPGTARTTTVHVEDAARLYFILAEKAEAGESYNATSETDIEQKAISEAICETLGVPCEQLDVEEVKEKMGHFWAIFMTAKCRATNRKAREQLGWSIQAEKGILEDIRSGSYVEVAKEMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9Z5</accession>
    <name>A0A9P4U9Z5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_521380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9Z5"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF647">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="10"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="298" mass="32370" checksum="991B226F3EC17A9A" modified="2023-09-13" version="1">MRALIRTGDKSPQTLRLDPNYPEPTPTDHPGSYIIRTKACALTRQELTWPEPKTPDTSVPGLDFAGEIISAPKSQGEHKFKPGEHVYALTTFTWEGNARDITAAHENELALKPKGLSWEETASIPLSALSAYQGLFVHGALKPPKEGNNLGKRVLVTAAFGGVGLWGVQLAHQADAEVVGTCGTSNVEFVKSLGVDTVLDYRKVDLLEWCARERGKVVSVAEPPDPKKPEDGVADGVQGVWFIVEPNGAQLAEVTNLLEQNKCQAIVNSVYELEQFEEAFKKLEAGHAKGKIILRVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAI3</accession>
    <name>A0A9P4UAI3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAI3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="961" mass="108667" checksum="FB3BFC65FB65C649" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBC2</accession>
    <name>A0A9P4UBC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBC2"/>
    <dbReference type="OrthoDB" id="3793408at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="433" mass="47760" checksum="5DF9AA229A7DDF4C" modified="2023-09-13" version="1">MSLPLPETPKTTTFPTIGTPTSAKVPLVHSPLNASKRDIWTAHQLEQFDAAHVLFPSAGDDSIGASSYTIRDFINEAVEFLSPNYSTRQKSSISKSMRKQYEFLLVDLEAPIPSSWTEALENDNIKDALSYFLKNFAKVAYAKTLTTHRTSIRTIFNACQNLIQQHISPSETLPIQVSPFSMTSTPASKVSGIFDSSSPLQHRTPFTPFFTPLTLKMDPEFGYPLTPEDDAIQFFDRILESRTQSIINAEFKLEYLDKQCAKKDAQIADLEGAASPDVCLEGGPAQPSERDVFDGLEGDMVLDKLQHLSQRLAELRHEIEGTELLVELKDMRIAQLQVLASADDALDTARETDLALEELRVGQIQEQIERFEQAEIGGRTSESMGPSLDTEGTSSPVSSTETPIIVHEEDNSATADSQALALESESGDQTSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDH0</accession>
    <name>A0A9P4UDH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_521203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDH0"/>
    <dbReference type="OrthoDB" id="3796310at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="279" mass="31614" checksum="7974A4692271AA70" modified="2023-09-13" version="1">MRDYRKMFPPQDRSPPQYVDTSTPLIPPRNSDKRTPVEQLRRYIIEIMGFTFDTDFTLLNEALGQTALCTCPTKSILTPEERAKLLSLATLIKEVKPKMTSGNAWLTVRYAEREAIAEAVVRPAHYVGLTVGYVLEIISTYAVHQCDPSKRALSFISQKKPYFYTFWKCLAFLGPLNIVLGLYSNDLWAHAHVIGVTVPCEEVRAVLGNAMQTYQKEVLGIKQVWQIKKVFSGESWTALAGALISEDEEDVIRSGRWSRERKEAKENAKAVAKVEAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDV0</accession>
    <name>A0A9P4UDV0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDV0"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF34">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G07820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="182"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="364" mass="40673" checksum="22DD552DB8B402BB" modified="2023-09-13" version="1">MSHTLLTERSLIVAGAAIALLILYHAVLALQTRSTKAKSLQISEIYVYPIKSLRPTKLKSALATKHGFEHDRVFMLLQVVPEGYKNMTVSTYPDMTQFLTSIEDRKDGRAVVNVTFRAFGREEKSKTLSVPLTPDTEKLEPINVDMHGSPTAAFEMPNEYSAWFSACFGYQVVLAYLGDNKREVLWMDLVQTQNPSLLARIPLLGSAIPQTPKITFADCAPYLVVSSTSLDNVSSRLAPDEPMDVTKFRPNIVLSGADEAWEEDYWRQVRIGSVDLVMKHNCVRCTSINVDYETGKPGTGGAGQVLKMLQKDRRVDKGAKWSPVFGRYAFWRGRDNGQVFKVGDEAVVTDRNKDRTAFNWPGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE45</accession>
    <name>A0A9P4UE45_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_519666</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE45"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2446078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="480" mass="55635" checksum="AD64A1D649016A41" modified="2023-09-13" version="1">MTSTSTTVACALLAIFLLSFQNVWRVVQTWRFLLQGRVMMLKHAQDNPHKAFSLSVPGNRLHILSSNEHWHDINNAHTSQLSPNAASREMFQPKYTFGFDWSAPREHVSLATVRSIRNMTLQIPLFQGRFVEILDQEFQQAMATNPQEEGWTRVALWTVLQRAITRINTLLLFGEDTAHNDEFILRGLNFVNQTTLILESVRLVPFFLAPVVEKLIKGRGHDRQFVFRTLKDLIAEREAYRKTMPESSRTKPRTFLEGVVDYSQDDRTTQQHVDSINSTWVISTLAIPVVVCQLLQDLYTHTEHFEALRKECDVIPLHESSRSQEISDYLGKSPLLEAFAMESWRRNCFQSNTAHRMAMKPFQFSDGYKVPAGEMIEFHQRGIMNDEARYPEPEKFDPSRFLGKNRSLVDTGIEWPFWGVPRYICPGRWHVANVEKLVAVYLMQNFEGKFKSTKSLNFDWRDSLVPNPKMVLLMKPRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE66</accession>
    <name>A0A9P4UE66_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_431281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE66"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000934">
        <property type="entry name" value="Allantoate permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2445897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="510" mass="56294" checksum="6EF49942E98292DF" modified="2023-09-13" version="1">MASHTAQGKEIEAIEPSPPVHSETSSQFDDAYETYKKNQGARIDAAEAKRVLRKIDVRIVPILFFIYLLQYLDKNGINYASAYGLNEGTKLKGQDFSWLGSIFYFGYLVGQYPSGYFLQRLPIAKFLGCTTLGWGIILMTTPACHNFAGIASNRFLLGLLESAVNPGFVLIMSMWYTSAEQPLRLEAYYCTNGIATMFGGLIGYAVGHIKSGLPRWMYVFLIFGSCSILMGIVTLLFLPDLPSTAKFLPEPERVIAVERVAANRQGVKNRHFKKYQAWQTLYDPKTWILFVMATGAQIPNSALTSFSSLIIKSFGVDTLGTQYLQIPGGAVQFLSLLTGGIICTRFPNTRCLTMSVANLICIIGASMLVALPASSKWGRLVGLWLCYFQGLGFSMSLTIVSSNVAGYTKKQLTGAALFTGYCVGNIIGPQTFKDSEKPGYHSAYVAMLIGYSIKLLAVLVLYAYMWSVNRKRDRESASGIHLTDEEEKAAVEAGMLDVTEIDNKGFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFN1</accession>
    <name>A0A9P4UFN1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_354953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFN1"/>
    <dbReference type="OrthoDB" id="3210850at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="233" mass="26292" checksum="2377D7AE5B739D18" modified="2023-09-13" version="1">MYIAVFSFIVCSAVMVAGQGLYNYRLCFGATWICLILYTVAKFVIYVFLVERIHVVRAPFVRRSRDWLYLSCLVLMSVSFLAVAVNAYLSPIIIMEADDGRCHMGIPGKASIPFMSVDIVVDVVLTSVFIYLLRPVVKMHGLNKTHVVRVPKSPILGREEEVHGTAMRKSIRKLLWKSLIGSLLIMIPTIANMIQFYIMQGRELALICLTLCTLDGKCDCLSVYTNTWQVLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFS5</accession>
    <name>A0A9P4UFS5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_232532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFS5"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="594"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="685"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2447818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="781" mass="85447" checksum="D224C482A7B0CF93" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG78</accession>
    <name>A0A9P4UG78_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_189453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG78"/>
    <dbReference type="OrthoDB" id="4502478at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="18266" checksum="594982FE69688295" modified="2023-09-13" version="1">MGKTPFAKSSPKTALIQRLGLYGYEGDRIYLLLYNEAIYGRDRLSGDYNSLTKYSKKHGVRAPYKWDDLSETARHKEILNIVRTASVCTRPYYQMGRWMTAEEENWVAEWFLWHSFRFRDNRNNQAAAQHSTGDQTTASSGPGQEGTSTGPFWATVLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGB5</accession>
    <name>A0A9P4UGB5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_222827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGB5"/>
    <dbReference type="OrthoDB" id="3582307at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="155" mass="18269" checksum="22B8BFFA3A5442F3" modified="2023-09-13" version="1">MSKTSCRSTLLLRRWHIMLGLPRQSPTRWYRDRLREELCERRAATTYLQKLSETSDVLFSISRALHDGFPMRQLPALSLRNAPAYLYMLAKYTSRWKFYRVAAKLCDAPRRESIREVINPDKDHKLLEVALRHDIDPVAFKVAAGKLQRFWPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGE4</accession>
    <name>A0A9P4UGE4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_207096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGE4"/>
    <dbReference type="OrthoDB" id="3772810at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040502194" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="24910" checksum="0BC9695B986BB7CF" modified="2023-09-13" version="1">MLDLHTLANLLIVSFLLAPPTAASPLWPNTTTPAAPPTACSTPTCQTFYPTSYSILNSRYPTWDQTPLHGNQDFFMLLRQRADTFQVATQVQFSLPVDNGTENSSSTCILQFQLPSKDMQTVLGPAPVVNVYQVTREAGVPATWDTYEPARNASVLVPVFGAVNGSVEAQQRIWNQTGGLIDVGAGECNGTLTWQMGMAFEGGDGVNYWDFVGVEPPFSPVQGFRVVTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI59</accession>
    <name>A0A9P4UI59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_517561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UI59"/>
    <dbReference type="OrthoDB" id="2519291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="141" mass="16568" checksum="EE038082E444DF24" modified="2023-09-13" version="1">MPDKAIPLYPFIIGVEATRKEGTTRKQFRDHYETFYVPLLKKLVGKTHPLTWTRRYNLEEGEGPFGVPKLLIGTDADMGWDCYSEMTFADELHCQQFITLMHSDEVEPMLEEERKFTEPEKLRMIVLRRDITIDDSARAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ47</accession>
    <name>A0A9P4UJ47_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_401637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ47"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="110"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="253" mass="27870" checksum="6C9E5D56E3F0B7CE" modified="2023-09-13" version="1">MADAKPDPAAEQVQANPSATLQKDETAKVTTDITDAKPAEDKPAASTVTETVANAASTATTAVKDNVFSMFGGGPKKEKKEEVDDADEPSGASKPKGGDENPENEEPDVDFQPVVHLTEKVDVKTNEELEEQTFKMRAKLFKFDRDSREWKERGTGDVRLLKHKENGKTRLVMRRDKTLKVCANHYVVPDMKLSPNVGSDRSWVWNAAADVSEGEPEAQTLAIRFANSENANAFKEAFIKAQQENEALFKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJT8</accession>
    <name>A0A9P4UJT8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_478705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJT8"/>
    <dbReference type="OrthoDB" id="3778474at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="583" mass="63888" checksum="0E4E71AB1F98032B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6Q1</accession>
    <name>A0A9P4P6Q1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_171781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6Q1"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF4">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2437733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="257" mass="29788" checksum="332B0BE53875955B" modified="2023-09-13" version="1">MFDYAHSTTSTHLIPQPSDLRLNPPESYLLIQDFLILTCALLYALCYFFYTVRTYADRTCAGTPLYMCTTMAYELYYALVMTSPTARFERWGFLVWFALDVVFVSVAICSAYPRAAWRRMVGVLVVGTVAGMGVLRWLGTLWPDEREQVTAYWTGIVLQVPISWGSLIVLVQRGDTKGQSLEIWITRYLGCFSAYGVFWWRYINAPQNWAYVNNFWSWFVILFTLFPETIYPFVYVWAHVQSRKKRGVVANGKVKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6R8</accession>
    <name>A0A9P4P6R8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_490122</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6R8"/>
    <dbReference type="OrthoDB" id="5333578at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF2">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040332647" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="10">
        <location>
            <begin position="17"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2439420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="223" mass="22912" checksum="1791C3CED83EC754" modified="2023-09-13" version="1">MLATTLLPLASFAALTSAHFHVLYPEWRGDSLSLETASQWVWPCANISETTNGTRTKWPTAGGSISINGSHEFAFTYVNLGLGENVTNFNISLVDNFNQTGAGVLCLKDAVKAALEEGLKAGNITGGTDGLDGKNASLQVIQTSHSGSSLYNCMDITFSKDAKPLDDEQCKNGTGVGGSPIGASEAQEAEPSGTGSGQPGAASSVKPFVGSGVVAVVLAMALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P711</accession>
    <name>A0A9P4P711_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_437491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P711"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040190369" evidence="2">
        <location>
            <begin position="19"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="302" mass="28868" checksum="C521033EE9C3336B" modified="2023-09-13" version="1">MYFSKSIIASALLGLAAATTHMGEAASGGLATSSTSAIAASETLAATGAASSAAAPAEATSGASAGELATHVVQVGGPNGSLTFSPDNVKAAPGDLVQFQFHPKNHSVVQSTFDKPCVPIQNVMPNMTTAFFSGFMPTNASVGATSQVLTYTIRVMDTKPIWFYCSQAKHCQGGMVGAINAAETGNKTMSAFKALAAGATENLSPGQAPGSGTESGSGTGTNTGGGAAQSSTAAGGEGGAAGGAAGGAAGGTGGAGAGAGTGATSTDSSAPAQQTTNAAPSTFGSQSFFGLTLGGVVAILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P716</accession>
    <name>A0A9P4P716_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_423751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P716"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="638"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="761" mass="83220" checksum="D3921CF98A463324" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7Y9</accession>
    <name>A0A9P4P7Y9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_467062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7Y9"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="78"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="539" mass="60569" checksum="4AD2297B90A23D95" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P804</accession>
    <name>A0A9P4P804_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1793-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_421544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P804"/>
    <dbReference type="OrthoDB" id="2580323at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616:SF1">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040465860" description="DUF1793-domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="60064" checksum="A23E1402858F0F39" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8Q6</accession>
    <name>A0A9P4P8Q6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_489995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8Q6"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="276" mass="29276" checksum="B2EB5E1B4C8FD041" modified="2023-09-13" version="1">MALLIDGVALVTGAGSGIGREVAIAYAAYGARALITADLNYSSAENTARESEKLATNPSFRTLALAVDVSDPSSVNSMVETAVKEFGRIDYSINSAGIGVQKPASIQNVDIDEMNRFWRINVMGTVNSMKAVSTAMIAQDSQQATTRGRTRDIGRGVIINLASCSSYMATPDLTQYTTSKYAVLGLTKNAALDLAKHGVRVNAICPSWVETPMVEAAVAGNKELEQMMQKVIPMGRIAKVEEVADVIVFMSSPLASYVTGVGWIVDGGTLLQLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9V4</accession>
    <name>A0A9P4P9V4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_340133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9V4"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF16">
        <property type="entry name" value="RICH PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11462" checksum="D102D66F1D37511B" modified="2023-09-13" version="1" fragment="single">IVVGAAGDLVFNPSSLTVTPGTTLRFDFLGLNHTLTQSSFAHPCSNASIFDTGFQQHNPYNESGAFIVDYLVESDRPEWFYCAQTIPISHCHSGMIFSINPAGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9Y2</accession>
    <name>A0A9P4P9Y2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_369765</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9Y2"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="423"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2439543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="537" mass="59587" checksum="EDB5C7DA0ED202E7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAE5</accession>
    <name>A0A9P4PAE5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate-binding module family 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_489087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAE5"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040479545" evidence="5">
        <location>
            <begin position="18"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="6">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="6">
        <location>
            <begin position="149"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="6">
        <location>
            <begin position="242"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="818" mass="86018" checksum="3613009768ACEFCE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBC6</accession>
    <name>A0A9P4PBC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBC6"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF32">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040502708" evidence="1">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="348" mass="38885" checksum="A102ABEF74B3890F" modified="2023-09-13" version="1">MWCSTLFTSILAAAATVDAYGIKKHVNYEVVTGVFKQDDAATEASSFNFTAENFGLIERKYPSDWTYWLQKPTSWQRLNRYIESLNLKAKHNERYTLLFLGRHGEGYHNAAETYFGTPAWNCYWSEKDGNSTVTWADAHLTPKGVAQAQDVNKFWKKLLTKEKIAAPQSYYTSPLFRCLDTARLTFAGLPLPKTRPFVPTIKEYFREGISAHTCDRRSTKSYIHANFPTYRFERGFAEHDPYWTALHAEPAADQDIRSKTVLDDVFASDRGTYISVTAHSGEIASLLRVLGHRVFGLSTGAAIPVLVKATTVVGSAPATSTLPYAPQKTCAVPPAIRDSSCNDCSCCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBC8</accession>
    <name>A0A9P4PBC8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_434647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBC8"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="51"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="622" mass="69641" checksum="4FA6216B8A87CEEB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBW1</accession>
    <name>A0A9P4PBW1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_97508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBW1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040181003" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11944" checksum="16A3D2102886247A" modified="2023-09-13" version="1">MSSARLGHDFFFFLSYYFASLLFESEYAHTPSVSSRWPSHGWSKGAVQVCGRADGAGSGRDYAGRMMWSAACRRRARGEREGKVFFCVWRCYVGGRGGVLRWARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC68</accession>
    <name>A0A9P4PC68_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_489216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC68"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="451"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="745" mass="82381" checksum="B065FBC12C6A1054" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCM8</accession>
    <name>A0A9P4PCM8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_466160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCM8"/>
    <dbReference type="OrthoDB" id="412536at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000152">
        <property type="entry name" value="Extracellular endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005102">
        <property type="entry name" value="Carbo-bd_X2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016282">
        <property type="entry name" value="Glyco_hydro_5_endoGlcnase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF41">
        <property type="entry name" value="ENDOGLUCANASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03442">
        <property type="entry name" value="CBM_X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001043">
        <property type="entry name" value="Endoglucanase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040479953" evidence="10">
        <location>
            <begin position="20"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="11">
        <location>
            <begin position="83"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate binding X2" evidence="12">
        <location>
            <begin position="395"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2440733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="598" mass="64535" checksum="35EA3F2843850A04" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDM8</accession>
    <name>A0A9P4PDM8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microtubule associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_363813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDM8"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41989" checksum="C89D36DEB955B38B" modified="2023-09-13" version="1">MVQPTRPSRNGFNAFARKIYNPLGFSKAYNFILWFIFAGALFGCKYLFIFPPLLTLARFIYLNFGGVFCPSGGSNSMIGAAPGECYWYRTFDWYKTGIILHLAGILPACLLVVLQFTPVIRHKAIIIHRVSGWLVMLLWIVSLVGTLMIARRAFNGGIDTQAWIGLVGFGSTICFVLAIWNVKKLQIEQHRAWMLRGWFYVRLLHHHGIILIIATNVISAVGSYYTVWPCAKISFTMRSNEATLEAYPECASYINESDLLQQAVVHAKFGGRPTEIGAALDMCFGMALWVALAMHAIGVEVYLHLTPKEAERLRNVSYQRQLEAGMRNPGSAGLTADKLGDSETWVPQVRKEESIDGGSTLASDAHIGAPMSKLSTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE29</accession>
    <name>A0A9P4PE29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein S-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_326972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE29"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12601" checksum="8E93C72ABD854555" modified="2023-09-13" version="1" fragment="single">LNQIAVPGVYLLIFFLGYPSQILFCYLDPAPLTRNELYISNVVLVLIYITYTKSVFVDPGTIPKSFGQDDKKEHEIGSERRGDGLKRTKWCRKCDAAKPPRAHHCKECKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE80</accession>
    <name>A0A9P4PE80_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Large ribosomal subunit protein uL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">60S ribosomal protein L3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_417731</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the large ribosomal subunit. Interacts with DHX33.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE80"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000004">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 17 18" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2442501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="392" mass="44105" checksum="2DEFF7BFDA11EBCB" modified="2023-09-13" version="1">MSHRKFEAPRHGSLAFLPRKRAARHRGKVKSFPKDDPKKPVHLTAAMGYKAGMSTIVRDLDRPGAKLHKKEIVEAVSIIETPPMIAVGLVGYIETPRGLRSLTTVWAEHLSDEVKRRFYKNWYKSKKKAFTKYAKKHSENSGQSITRELERIKKYCQVVRVLAHTQISKTPLKQKKAHLMEIQINGGSIADKVQFGHGLFEKPIEITSIFEDNEMVDVIAVTKGHGYNGVTSRWGTKKLPRKTHKGLRKVACIGAWHPSHVQWTVARAGQMGYHHRTSVNHKIYRIGKGTDEGNASTDFDVSKKQITPLGGFVRYGEVKNDFLLVKGGIPGVKKRVVTIRKSMFVHTSRRALEKVELKWIDTSSKFGHGVYQTAAEKKTAVGTLKKDLTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE89</accession>
    <name>A0A9P4PE89_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_487750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE89"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="255" mass="27462" checksum="6EC152357EC4FB2D" modified="2023-09-13" version="1">MSPPTAKSTFEAPDGTSGAIMRIPDGCIGEQAELTKNGFGSNDFIDLSNICGAGGNLIVQQNLNDAWNRADQGARDNLSQCTHVSDGVVKRIDSPKDFPQLEFVRSFADGKTYVGVGAWGGSPGNANDNAQSTIRKPQGQYARDTPESVMAAAYQEPMYISSADDGSPGIVLNNASQRECEYFFYDNYWNGDGTAGANFDHPLTSVKLQPNETQFVSLSNTFKSRLQRGIELPATRVEFQVEAVDGHGAHGDILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF84</accession>
    <name>A0A9P4PF84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_22106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF84"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="501" mass="55139" checksum="71E8A4FC904FE4CB" modified="2023-09-13" version="1">MATPHTKTDMGGLAEPGIGFEHGKQVEAGSIEGSLAEVDPVAEAKLVRKLDLHIIPVVMLLYLFSFLDRVNIGNARLYGLEEDLGLNSTQWQTAISILFVTYILSEVPSNLVLKKLTPSRWIAFITVSWGIVATLTGVVQNFAGLIVCRLFLGAVEGGLFPGLAVYLTFFYTKRELALRIGYLFVSAALAGACGGLLAFAIGHMDGVAGERGWRWILIIEGLPTFVLGIATWWILPDEPATTYFLNDQEKKLAINRLKRQTGYTVSAQEFHWQDVRNGVKDWKIWAFSFAQFGCDTMLYGFSTFLPTIIKGIQPHASTALVQVYTIPCYAVGAITYLVVARLSDYQQKRGVYAVALGVVAIIGYGMLMSNSSAAVRYAGCFLVAMGLYVNVGLPLAWLPTNNPRYGKRTIATGLQLSLGNCAGIMSSFLYPAKEGPRFIRGHAVTLAMVAFASIVYAFMWFYLARVNARRARGDEDHKIQGMSDQEIRELGDDSPRFVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFI1</accession>
    <name>A0A9P4PFI1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_486985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFI1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF182">
        <property type="entry name" value="POLYAMINE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2443027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="239" mass="26263" checksum="FF0886E78E3CCAB9" modified="2023-09-13" version="1">MSGNQPASSSQPPDDQKSTMAPIEAKKNVSKNEFDWDTDGINPLNWTVWKRTYDTVLPAVFGLVVTFVSSIYTSAVADITRSFQVSQTIALLPFSLFFVGPLSERYRRTATYLISMPLFAVFLLGSGFSPTFAGLTICRFLTGVFASPPLVVDAGTNATLWLPQDRTAMTTLFALFPYLGPALRPVVGGFTAASKGWRWTQWAVLFSAVVAVHEIGRWMGSYCVRIHLRRAYADSVGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFK7</accession>
    <name>A0A9P4PFK7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_64394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFK7"/>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="244"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="305" mass="33731" checksum="7D42208DDB31DC40" modified="2023-09-13" version="1">MPSRDDKYTDPELRSEVKEEIQASDKGGAPGQWSARKAQMMASEYKKRGGGYTTDEKDDKAKHLDNWTEEEWQTKEGSGHAKQDDGLPKKAWEQMSEAEKEETDQKKQEGSQEGNQYVANTSKAKSARKDASKVDEHAEAKSKDKTDTKEAQDCTQHWEDEEHMKKGQSMYREFKRQNGNDEASSAEVQSDSGSAHGDDQEHPTPKKRGRGANASAANKKQKKSGSSEEPNGAAGDKTRVPKVGQKVQWKALPGLVDGDVVEVAYEETTIEGKAVKASKEDPRIVLRSSSSGKIAVHKPEAVYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFN4</accession>
    <name>A0A9P4PFN4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_392008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFN4"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="53"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2442278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="282" mass="31705" checksum="D62D1B7668A4C91D" modified="2023-09-13" version="1">MASIDLVNQAPAGTKLWILHVGNLEADEGWFKRAGNTSTLSNKNPENQRRKLIMLSILIEHPTDGLILYETGAGDNYPEVVGSPINDIFARVDHDKSMDLPAQIKKTGHDIKDIKAVIIGHLHLDHAGGLEPFRNTGIPIYTHELELKYAFYAVATKSDLGVYLPHYLTFDLNWVPFHGSFVEIAPGINLHHSPGHTPGLSVMQVNLKESGTWIFTSDQYHVKENYQDDVPQGWLARDHESWCRSHQMIKGLARRTKGKVVLGHCWDTIKDLGLEFAPKTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFX3</accession>
    <name>A0A9P4PFX3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFX3"/>
    <dbReference type="OrthoDB" id="3784410at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="300" mass="34500" checksum="B5DB1B4F0ECF11E7" modified="2023-09-13" version="1">MAAASTVFGSPEILQQILSELPAFDIIRYQRVSRVWHKLIADSPLLQYKSWLRNEYPDPAQHVRDTDFIPWDRKYPHGSEAARDHETKRYLSNITRHLNPIIVGRALEDIPRNAGSCFDPIQDMDKDGFGGYFNFRPVHIQALCQWYEANKDTESRWGHLSLYRPETRKISWDVPCTDDSGLPFSLKAKSNDDPDYTGNGVVVVNKRPGEPLFLTVGDLLANVGDLWEKWLDYERETHYLSHDGEGCDSSLGLPDDCISFDDNEDQEEDSKENKVLGTDRHIFEGISEYYIERCIRIASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG17</accession>
    <name>A0A9P4PG17_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_495225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG17"/>
    <dbReference type="OrthoDB" id="3792376at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="421" mass="46514" checksum="B053249E31324815" modified="2023-09-13" version="1">MALRGHGLPRSRAMTFNMLTDPELSRRSTVPGPSNSHRNSRRWNGRRSSHASSLTLRQPESPRDVSRDTTWQTVSWFSEPLFELPLFDLDFEDWCKKILEYVDREDLEIASASEDIQGNQSREMSWITDTASSLPHLDSLHWQQEQCPTRSPSLGGRGIKQQRRNAIVFGLLQASLANPRASSAGDTHEATTPSSSLTGNLHLPSGYTLISGISGGYRQSPEALGSGRNPPHHHSETLRVLEGNGPFVLDARDISRSQFRGMQSDSDDTITLGSSYQLQSMLRRDAVDGSPVEEQGDPWTSGVFNQLGDEIVSSLRNMDGAAARDLMEEQPSPDEVEDDIFSLLDEMGALGSNNRGEEQENRASPGDAQPEPRRESVDSEDRSSPAGSPLPSLPIIVPASTGSKKGRFGRLGRWWKRVVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG42</accession>
    <name>A0A9P4PG42_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Anaphase-promoting complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_521775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000400">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000435">
        <property type="entry name" value="Ubiquitin ligase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="8">
        <location>
            <begin position="1820"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="856"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="856"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2444445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2033" mass="224238" checksum="B4BDEED27DFE2838" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGB3</accession>
    <name>A0A9P4PGB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_36791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGB3"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="683" mass="75378" checksum="06862EF1E27C28DF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGC4</accession>
    <name>A0A9P4PGC4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGC4"/>
    <dbReference type="OrthoDB" id="10621813at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="259" mass="27867" checksum="05DA5ACD0FBC0EE0" modified="2023-09-13" version="1">MGASIQLAPSQADFPPVTLHFPLEGGTMGLPDGRQITFTPRGAQMPPTAQPVALVNEVVARVYGVTDSEMITRAAESEVPDEAMTDVDVDDADGGRATVEVGQLDAPYSVFGEEDTATEDGLIAFRSFSSVAVGGGEEMAGDEHADDETATADENISPHHHLPSTFTAPNRKAAKSNKPTKLHTTTSTPEPYPDAQYYGFNSDGEFEGFSEPESISEERSEYQPDEEDDEDERDGEIELVGRKRGKKTVGRIKTNTEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIB3</accession>
    <name>A0A9P4PIB3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_430980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIB3"/>
    <dbReference type="OrthoDB" id="5407957at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="236"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="739" mass="83830" checksum="53BBD18999DF7D60" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIF0</accession>
    <name>A0A9P4PIF0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_269525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIF0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="167" mass="18160" checksum="79978277F79AC002" modified="2023-09-13" version="1">MRMRASCLATRSHRRVGCAIAFLSTKQRRPTGELHCNQSNAQTHRSLARGTAHQACLTLLRWGRSGAGKDRMGYGVVLTVKMRGTALCSVASDSLELYRLRRGALQPFCHPSRGIQHKSGDSSHVAASPVTQSVDRVLGPWSLLHKLGSLTSLVPAWAHIEPAVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIG5</accession>
    <name>A0A9P4PIG5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_432786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIG5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="91" mass="10275" checksum="0EDCEEEE2F267BC5" modified="2023-09-13" version="1">MLGDHGARVEGISPSPIQIPPRERVTVLYSKHCLEREAPTLGAWQLPMASVMELYYYCGYDSSLYSVWTLYIVSDPILIGSRIFFGAYAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIU3</accession>
    <name>A0A9P4PIU3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_513335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIU3"/>
    <dbReference type="OrthoDB" id="10458634at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040399923" evidence="1">
        <location>
            <begin position="24"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="151" mass="15740" checksum="7DE4106E8CCEF974" modified="2023-09-13" version="1">MKLQIYLGLLSALSALAAPVAKAGVDNTDTSNLVLYGIAVAVTASDEDLKKAKRAAKAGVDNTDTSNLVLSGIAVAVTASDEDFKKVKRSTGSNNIVKIRAVDADPNANPIPIGVLAIVLDADDEEKREAKLINPYIDDVEKADAHAVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIX8</accession>
    <name>A0A9P4PIX8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_484983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIX8"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2444900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="344" mass="38089" checksum="5979C01272F54E3B" modified="2023-09-13" version="1">MCNLCDQLRSLGEKHDLYDMSVEETPTNGDWGSGILTTDLEYQTMIDLDEKLGLRELRAKIHKHAGLDVKKDCFLNRLSINAEFCFGEGSVEIVRNYLDTGVLQSYYDKTYGQDRCWDGTDVTKYIVLGACVLTLGCVLPEPMLPKLKALVCPIYQAFVLLRQPQPNCYIATPLARQQLLEAIKNHHPGRPYSYGNKSMYESMATGGMSMPGCTTIVKDVGPTKVIEVIAEGKTLLTSCVGVPTDDDLALTACYPYHVCGGCGASGSAYQVCSGCKDRKYCSKKCQKKHWKMHKTVCQALSKDAMDRYLQGISAIKLQSSTPLVEGMKINIPIDPDHFLNKEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ31</accession>
    <name>A0A9P4PJ31_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LACT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_431377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2446005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ31"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="639" mass="71695" checksum="9985D5105D03C780" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJZ6</accession>
    <name>A0A9P4PJZ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_411107</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJZ6"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="136"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="140"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2445347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="515" mass="59414" checksum="F4EC07B60BDE7CBA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK35</accession>
    <name>A0A9P4PK35_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vitamin H transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_512657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK35"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF15">
        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="452" mass="51073" checksum="BBE746130B102BB4" modified="2023-09-13" version="1">MASHSGVPREKWWKIQWFSDDDTPEEKKFITKLDLILIPYLFVTYWVKNLDQNNLNNAYVGGMKEELGFHGNELIRLQTMYIVGAMAAYRFLVGWFEAAYFPAVHYILGSWYRGHEISRRGGIWYTGLPLGTLTAGLVQAGATRKLDGVHGLSGWRWMYIICAIVTIPVGLAGYFILPGTVDKPNKFVLNDHDHRVARERLKKKGHKVQGRLKFNHIKQIMSSKHFWIVVLVDVLFWNAGINSGAFLLWLKSLKRYDSATVNEYGTIPPAMGIFFTLFANFSSDLLWGPVWAITFASGMNTLTNLILVIWNVPEPAKWFAYCNAGWSYALSSVLHGWVNNILRDSPEIRSFTLVFINIIAQSSTAWTGILAYPTVEAPRFLNGYSFSFSMSTSLIIGAHLLNLYLKRRRDPNATQSTPASDVEVTDDGSSQGQIEESDQSKSLHSTQIKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKL6</accession>
    <name>A0A9P4PKL6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_431076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKL6"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21297">
        <property type="entry name" value="CH_FIMB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="78"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="227"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="351"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="475"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="589" mass="65732" checksum="E858918915799890" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKP3</accession>
    <name>A0A9P4PKP3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_411960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKP3"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2445815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="155" mass="17859" checksum="0B77FEEAA477CFC6" modified="2023-09-13" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMAKKRKKKVYTTPKKIKHKRKKTKLAVLKYYKVDGDGKIERLRRECPQPECGAGVFMAAMHNRQYCGRCHLTYVFDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLM1</accession>
    <name>A0A9P4PLM1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_430264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLM1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="101" mass="11194" checksum="FFA76609D66306B0" modified="2023-09-13" version="1">MYGGVAEIGHLPPKAQAITKLSANPFIFAIVAFSRFSLLLKWPFSQLYKLFMRLSLTEEAKQSFRQLVVFATKGLLAAEICVSEATAQCKPLHSLVRTPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLV2</accession>
    <name>A0A9P4PLV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_257583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLV2"/>
    <dbReference type="OrthoDB" id="4828117at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="140" mass="15099" checksum="9C7A49534F12ECD6" modified="2023-09-13" version="1">MPINWQDPEVKDRILASIIASFGTPINCREVARIFGPEATYDAIENFLRKPKKKAKELAAEAAARGTSAPAPAKQQRAPRTPKKSDGVKSGRVTKTTPKKKAGSPVKKELLEGDEDVFGGGAVHTPQDDFEMGEVLDGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMK0</accession>
    <name>A0A9P4PMK0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_383500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMK0"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="888"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1186"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="918"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1186"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1250" mass="139499" checksum="D328CB9DBDE83950" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMY9</accession>
    <name>A0A9P4PMY9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_386764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMY9"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2445874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="211" mass="23779" checksum="54E90C8CBF76C41E" modified="2023-09-13" version="1">MSKSLAGKPIVRKLFSSSQVGVVVSAGRMSKAVKVRIAAQEWNKKFRKHFPSEQNYLVADPNSSLVEGDVVRIASGWRTSKSIRHVVTSIVSPFGEPVENRPPILSDEERMQIRIKERLLKDVRSAAKGRQTSLQRLAEARRQKLQIPSLEEAMANVRIAEQQEKAGKNEAHKGHTGQAETRKERRIEAGRERKQEKKAEAQVKRARAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN44</accession>
    <name>A0A9P4PN44_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_483106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN44"/>
    <dbReference type="OrthoDB" id="10601405at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="528" mass="58084" checksum="302501FA47B13EA7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP65</accession>
    <name>A0A9P4PP65_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_230038</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP65"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="519"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="728"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="288"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2447690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1125" mass="124176" checksum="56DD6BFF7D146D2F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPH0</accession>
    <name>A0A9P4PPH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_233390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPH0"/>
    <dbReference type="OrthoDB" id="10529390at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040411070" evidence="1">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="141" mass="15596" checksum="1BC3020BDBDB523F" modified="2023-09-13" version="1">MQHFPFRLALSNLLGTYTRALQPAPATPCTSLLCFARLFCPLHASYPKLCALRPVVTTIPDTHQRCHTPPHNSALYILPQALDTFSSLFDYIDTFVSLCCCCIAALFCLRAISCLYLCAMDCNMALASTDGICFPCCLYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPY4</accession>
    <name>A0A9P4PPY4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_383584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPY4"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="515"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="665" mass="72245" checksum="ED5B3BAC88BFB937" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQT5</accession>
    <name>A0A9P4PQT5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_441043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQT5"/>
    <dbReference type="OrthoDB" id="3792830at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="352" mass="39605" checksum="0EF407B4B9AA87D4" modified="2023-09-13" version="1">MDGAQLSIDQTFRDAQQNSIRHLKEHLPHSHTLEQLCPLQRFGHNDTNLPTEDLGDLHKLPVELRCAVLGELDLKSLLAFSKVNRCAVRAVESMQSWKKVMKCAPNAIRMAIGIQTTHLFTVDQLASALDQRKCVDCGLLAPYLDVFTLDRCCLNTGGGCGARTPYRCRVVDKDWENFGIPQNHVGRLQLSSFRPLPGYYLHGIDDDFSELCIKPEERHLVFDGDAVVKLLRTVGHSTFLSGDVVLIDDWEDGYNLGFWHLSAVFAQWPSILDGEYALSMGVFCGICRNTSKYQGLRMDNAFYEPWNPISLSEGEEKELAMRAPLFSESSELIDHMKEVHGIVGLHDCADRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRA7</accession>
    <name>A0A9P4PRA7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_406875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRA7"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040479547" evidence="1">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="465" mass="51624" checksum="52E5E3C3F88993F0" modified="2023-09-13" version="1">MGSPRFVLAAAAAFQAVAGHVASPIEASERVFSRQAVANGSWPYGPFSTKDRDIVDSRGEAVTWAGVNWPGSGETMVPEGVEWSSVEDILDLTKSVGFNFIRLTYAIEMVDQIYERNGSDVPLEVAMITGLGYENGTKVTNEIVAKNKGWTKDTGRFEVWDRIAEAALERGLYIHPDVHVGKAQWCCNNTDGNAWFDDYNFPVKNWHRGLQYVANWAKKHPNVVSMSLRNELRRAINTTAPTSTTGYNWLTFVGNYTAATDAIYSVNPDILVTWSGLQYDQDLSALTSGLNLNTAPLYKGDAIRDGYRRKPVVFDLGSHPWADKVVYELHLYSMSENLDTGNCPIIEAELYQSGFNALGINAPAACNITKDCPKAVRQTPVILSEFGSAQDSSIFNDTLQGCLKQFTTKNNVSWAVWSLAGSYRIRSGGQGVSDTWALTNYEWDGWQFEEGIEKWWKPWAKASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRN9</accession>
    <name>A0A9P4PRN9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thymocyte nuclear protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_323962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRN9"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000003">
        <property type="entry name" value="Thymocyte nuclear protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="6">
        <location>
            <begin position="110"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="274" mass="30019" checksum="24AB4F297F575C8D" modified="2023-09-13" version="1" fragment="single">MAGARRSTRQSASAAPKYAEPDSSASEDVAPKRNAKKATRRKRAREDDAEDAVNADSPPPPKKPKAPKRAPKHSPPAAKPTTPTIEAAPPSSLEPSSPSNRTPSGAQEIYWLLKAEPLPRFENGVNVAFSIDDLAACTRPEPWSGVRNPQACKNMRAMRKGDLGFFYHSNGKPSGVAGILRVVEEAKVDESAFDSKDAYFDRKSERETPRWWCVGVEFVRKFGDVVDLAAIKAHAGKGGTLENMQLVKQGRLSVNRVRKEEWDFILELAGEKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRX6</accession>
    <name>A0A9P4PRX6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_428340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRX6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="73" mass="8039" checksum="C8414587AA1CCBB1" modified="2023-09-13" version="1">MQNASRRKRIFVFHAGVSIPVSYSCMQVRNARSSSSAQHSRNIESFHEMYMAVRTGHNVASGPSLPPPSCSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSC8</accession>
    <name>A0A9P4PSC8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_427573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSC8"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="296"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2449370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="663" mass="74240" checksum="91239DAC1DC35EEE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT98</accession>
    <name>A0A9P4PT98_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_460404</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT98"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2450955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="623" mass="68245" checksum="E149ACFAE2A31C09" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTS3</accession>
    <name>A0A9P4PTS3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_137504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTS3"/>
    <dbReference type="OrthoDB" id="10401096at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="154" mass="17240" checksum="F136421220218431" modified="2023-09-13" version="1">MLGEEPNNQVFEGVVAGREPCGKGTRLRPRMECALRSQTYDPGGMCSTMTVKLIVMACPKRRSSIVYRRLPVACEVCLTPRARWVATAPKVWMRCRRLVLQYGGLDTRRMTIARMAPVSGRCALGIDRRKREKKGPHMFLCPANVGSVKRTGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTV3</accession>
    <name>A0A9P4PTV3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_469313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTV3"/>
    <dbReference type="OrthoDB" id="10401965at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="166" mass="17684" checksum="EB93DEC76D630ACF" modified="2023-09-13" version="1">MGQTVTSHVCFTFCLFIPLFGGCRICLNDCNFHKNDPKCKGKGKSELADNILNTPMIQDFWGNLGQVKTPPDMCGHFNGTFTAPGTCAFDFSYVDSAGFLRLVEGVDTAGQLCSVLKGGFSDGQCVIDLKDTTAKGDGTLEVKKGACAKLKSTWNGATCEVPGYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU17</accession>
    <name>A0A9P4PU17_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_221901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU17"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="165" mass="18552" checksum="063AD44023524A44" modified="2023-09-13" version="1">MRPDPILRKFRCLLVAARCRTRDAESPRLNNDSLAWSRSVRQNGADFRESLRPIGAPCRCYQSLDMRPREAVCHVEPGLLDELTKIPMRTQKSISLHSAAVQPSVKAEARHSGMPAPRTMALVLAMRGSGCFFGMANLVTEEILGPRRDRFLAREFGRRDACNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVD2</accession>
    <name>A0A9P4PVD2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide cyclase/dehydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_150686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVD2"/>
    <dbReference type="OrthoDB" id="2586183at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21582" checksum="8FD257993E708F6C" modified="2023-09-13" version="1">MANQSSILWPERLLPGYTDNFVSNEVIAVNLTAQQVWELLADISRWNSYYKNCAQITEPDAGSYLKEGSVFKFSTFGFPPLTCTVKESVVPKQGTAGRLAWHSTTDDGLELYHAWIVEELEKNRVRILTQEVQNGPVFKEWARDAPNKMLLGHQDWLDGLVQAARGQEVRKTNLESVNFPVRQLDAEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVV4</accession>
    <name>A0A9P4PVV4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_348783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVV4"/>
    <dbReference type="OrthoDB" id="3595619at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="348" mass="38977" checksum="E559C72E6C1632DB" modified="2023-09-13" version="1" fragment="single">MLQEKRKPWLAIGCCASERRDSIEEEDGRDASRAVESDLKICYDQPQSREFPRAEPVSPPPRPATSQSMGRHVSQWVTTSRDFASRASSRASVHTLTRPRKSHSKVRRLSISGPTEFRHDSGFDGEEGIQSMIDDAPMPVRRRRSFRPLELSIYLSDGRLSPLPDFKHDNWVEMPQMPAEALVRNQDSRTNSISSDPSTASYLVQRKPVGSGSRRSSVQSTQSVQSRPLSASLSTLPFLQEEPKRQAESIRSTATSRAGSIRSRTPSDLYRRGTLSPPRILSRLPSPSRARSNTAPARPGSVRRAKTDVDEAIRELNTIVEERRAEAYRSRNQSPALINRLPLSPSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW54</accession>
    <name>A0A9P4PW54_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_452022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW54"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="524" mass="59864" checksum="1F14C6983F45AC41" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW60</accession>
    <name>A0A9P4PW60_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_3839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW60"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="420"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="868"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111417" checksum="526CCBFC19E4CCAB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW78</accession>
    <name>A0A9P4PW78_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carbohydrate esterase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_350854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW78"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF9">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040313416" evidence="7">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="45"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="251" mass="26300" checksum="3269E6A3361E91A3" modified="2023-09-13" version="1">MGFTTLLVASLAVATSAVPLLNPIQAIQAAGPPAGQVITKCSSPGMIALAYDDGPYQYTQKLADILSNGGAKGTFFVTGTLYGCIYNQKTALQNAYKAGHQIASHTWTHPHIGSLSASALTTEMTKLETALVNIIGVKPTYMRPPYLETSGSVLSTMKTLGYRVVTDDVDAEDWNGKTPAQSQAKFQAAGAGGNGHIPLMHETYQGTVETLTPWLINWAKTNNLKLVTVAECLGDAGGAYANGTGNGQSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWL3</accession>
    <name>A0A9P4PWL3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_503277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWL3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="187" mass="20822" checksum="0B5B2DC6161730C6" modified="2023-09-13" version="1">MDISDRDESLDGESQDHDIDEEASNGGEYAQYTEDRVAAVALMHYDEDMANTGTVTPPSRTRLNQVLRLDTTVAGLGQSSIEPQANDNSAPVIPPFSPLDQGGYSPMNFRFTENPLSFPNSPTSPFYSPRFPTQSPTFLDYSPTSPAYSPVSPRYSPTSPMGPQPWYKSSTEFEVRIVRFRRSRIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX57</accession>
    <name>A0A9P4PX57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor IIA, alpha/beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_141257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX57"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000006">
        <property type="entry name" value="Transcription factor TFIIA complex subunit Toa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="138"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2450524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="380" mass="42770" checksum="A69AB330D0960BBA" modified="2023-09-13" version="1">MSNNAVGLVYQQIIERVIQASQNDFEEFGVDQSTLDEMKQGWQEKLSGLKVAQFPWDPQPEPPRQPPTVPSNVKPDHELHPPVSAPQDGNPSYPGAPIKSERAYEPPLSSYPQAANGGYAGGFNGEIAQQRAHALVAQRMHNQQQTQPQQQQQQHGGPISMQQQQQQYQYQQQQRMHAAQQQQQAQQQRASQPMQQRPPQPGHPYNPSQTDGPGDALEDWKALVAARRAVSDQDRAEADQQMRARLDALASRQDSGLMMPLNQMSKGRRRKAAVRVLQEEDAAKASLSTFATVPGPARFDGDDAKEEEHDSDAINSDLDDPEDDDNNGDDSDDETMDYMLCTYDKVQRVKNKWKCTLKDGILTTNKREYLFHKANGEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXI9</accession>
    <name>A0A9P4PXI9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_18505</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXI9"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="264"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2452085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="529" mass="58583" checksum="5DBCC395FB1DD696" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYG6</accession>
    <name>A0A9P4PYG6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_467813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYG6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="166" mass="18440" checksum="3D55542E3A51F368" modified="2023-09-13" version="1">MLDVAKTVCGARASRLGCLLIHAETGSPKTRLIRATGYKFMDVLSCSLRCPCQSEAGVSSIRSRWAYRMGWLQLQGGEVPSRVQIPAHFAPVLPRSKMPHTNSQRAGSAYRVMRTAAPLKHRTEGLEPETRENSLETRKHLSISKLEDKDAQALQRDRSLRAARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4C9</accession>
    <name>A0A9P4U4C9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_449571</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4C9"/>
    <dbReference type="OrthoDB" id="3785142at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040152480" description="CFEM domain-containing protein" evidence="11">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="12">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2437809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="105" mass="10740" checksum="7793E50048C82538" modified="2023-09-13" version="1">MRSLFVAVFAVATAYASASPASPTPTNKPTPPPASHGDDAAVSVSSVGSCPQNCWNESAVKAKCDPNADDDCLCGPFFDAVTTCVSQTCSIGENLSVLNTLEPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U585</accession>
    <name>A0A9P4U585_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_400222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U585"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040236392" evidence="5">
        <location>
            <begin position="23"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="578"/>
            <end position="579"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="624"/>
            <end position="625"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2437451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="643" mass="69536" checksum="B27F769D44770B95" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5P8</accession>
    <name>A0A9P4U5P8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_506501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5P8"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="81"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2437212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="447" mass="49129" checksum="A260788CC5F300DD" modified="2023-09-13" version="1">MTSSALPELKLPHLPQANHPAASVSQEKDINDKVNEATSDKATAAFIRRVLCSHDVLLGNGERGRNTPRPIEEVLPPLTSSNEVDLQLYAIIAVIIKEFVHTWYSKITPDHVFVNEVIQIIAHCTRALEQRLRNVDLETLLLDEIPGLLEEHLSAIRLSDRQASSQHSLVTDARVIYHTLHPHPALSPVPTDTVPSSITEQRESESMWRQLLIQGVLAVLLPTEDLENGCLRALVAEIFAEMILGNGISGKACEGWLLWEGITRIAEVLQHQGAKEEESQSYDGSLEQPLSRLERYGLLAPPVAEQDGSSRMLLGNTKHHQNAPMTANGLFWMIVQYVFLAGTALRAAIGIIATSAALPLRSAIAIGGQSAFEADHETPLAESGNRAERQLLTSKRPIVSMKLWSCASQLVELDARMPWLSGFISMLRWGVLAGPGRLGNMNGILDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5V5</accession>
    <name>A0A9P4U5V5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_181800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5V5"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="364" mass="38583" checksum="3CBADAFEE89E4419" modified="2023-09-13" version="1">MSPHNDAPSPASSFNSRSEYPIHHQAVQSIYTMNHYTEFDTSSIESGDVGLRRSLVPGIYVPTIAFFDPATDNVDVETTANHAVRLAKAGVAGITTQGSNGEAVHLSHKERNLVTSTTRKALDDAGFGYMPLIVGCGAQSTREAIELCEEAAAAGGDYALVLPPAYYQGLFSKDTVASFFRDVATASPIPILIYNYPGAVSGMDLNSDVIIDLAQHPNIVGCKLTCGNTGKLNRVAAATRAATVSDPGSGFMCMGGSVDFTLQTLIGGGSGIIGGTANIAPKACVRIVQLFEAGKYTEARRLQAVVARGDWAAIQGGIIGTKAGMMAHFGYGGYARKPLPRPNKEETNKWRESFEELVRLESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5Z4</accession>
    <name>A0A9P4U5Z4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_501836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5Z4"/>
    <dbReference type="OrthoDB" id="3801080at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43998" checksum="15F323263CE8C390" modified="2023-09-13" version="1">MIDVRAMTSQFSLTTRFVLHQAGHLRDTLTTHLVLHHAVYVNQAPPPLHLSIHHTPIMSTRVSTLKTPTMSKSAEQFPFLELPGELRNQVYREVLRLDELPNTIVVRLKTPDSSSEGKHTTAWTLTQVNKQLRSELLPLVHPTRLAAVALCDLAGYVQTFYVFRDAGPVNSEASLNSTQTFATKDPELKIWTSRKSLHYRLPAAGVDLLPILHALEHIHNVQVSFHTWCIYNWELAITHQLHKTFSQWRADIPRLGLLDMTLRTKYDGKTQYPCGRQSSSITLQCTATKHTSQKKRVLDLCAWIWKTGLRTLHKRVNGLTIAFVTPKTKREQATEVMFSVFKNSVKMEWKCRGNYCVARLVDKKTGSGFVVEKMSVEGKDVLRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6R9</accession>
    <name>A0A9P4U6R9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_458592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6R9"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="105"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="302" mass="33186" checksum="9D1D0F71D65BFBA3" modified="2023-09-13" version="1">MSWLLYTMAAPPILIVFLRALSLVLPGKLAQLASFAAFFITSMILMSCSAMYGVFASIFLRAVGYGGLSQWTTGRSFKWAMWVITGVTFRVTNSGGEEALLTRPAVFLGNHQSELDVLMLGCMFPKYTSVTAKKSLKWAPILGWFMALSKTVFIDRANRATARAAFDSAATTMHTQRQSVFIFPEGTRSYAEQPELLPFKKGAFHLAIQAGVPIVPMVVANYAHVLNVKKREFHPAVVDVSVLPPIPTKGMTAENVDALMKKTRDAMLDELIRLSHVSGQGNGAPLPRASGRDDQGELRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7N5</accession>
    <name>A0A9P4U7N5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_436025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7N5"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF18">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="336" mass="37941" checksum="2C09C2284D1AD68B" modified="2023-09-13" version="1">MHTLELHQVITVAWSLTVIALLVTLGRFAIHWHRRQRIAWDDFFNGLAMAFLLAFTATYQVYGPADYTKQLYAMGLIKEDDVIHSDETRNARYNAANALLFWCVIYAAKASFLALYWHIFAFSTKFRIAWAVTTAYIPTSFAITFMWSFFLCGNPKYFPDAQPQCHDNAPAMVIPMLSAWCTLDLIGDLLLAVLPLAMLRPLLMRTAQKLELAFIFLLVAVNMVLTILRTVYSIDVDLARFPDQNVLWCFLQASGAVIVCALPCYRGILTRKKADPLRNDDMTASESEFADIWQRYIVSIGESKDGSRTEREKDLEAGVVGGPPGTQTQISEISRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7P9</accession>
    <name>A0A9P4U7P9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_99653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7P9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="157" mass="17059" checksum="9BDB8B750E2C18C4" modified="2023-09-13" version="1">MSRSPTYQSCLSPKTPLHPASRAKAERKRGRRDVTAHAMHRVRYLLGMVVSARLATGNELGGWCGGYEGREGHEGAAGRRDIVAGLDWIGLDWGVVLYWCNRVELAELLSPGGLVMATVDIALGNCRRSDVLALTQTLVSERGEERSALASRDCPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8H6</accession>
    <name>A0A9P4U8H6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_475403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8H6"/>
    <dbReference type="OrthoDB" id="3800095at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="542" mass="60194" checksum="EB5ACCCCA8BC57D8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8Y8</accession>
    <name>A0A9P4U8Y8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Anamorsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_71761</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8Y8"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11000:FF:000002">
        <property type="entry name" value="Fe-S cluster assembly protein DRE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11000">
        <property type="entry name" value="Fe-S cluster assembly protein Dre2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="202"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="10">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="279"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2441411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="305" mass="32415" checksum="2D14D67C850318BC" modified="2023-09-13" version="1">MARTLLLAGPSIAAHPEVLDKVYEIHHRSSADLQMLDRLAAGLVQLPSSTYDVVLLLTDADGTTRESHKLLHRDVMNKVAGALKAGGLLKSQDGVFGAAGGAVKTEAILAGLIDGADGMAKPEQVESVSIPLKLRKKANGSVPLNGNGKREQAPSVQPVQPAGVGFVDFSDDLDAEIITGEDDDLIDEDDLITEEDMARPVVQPPECRPKPGKRRRACKDCTCGMKEKLEAEDAAKRTTADNALSTMKLGTDDLTEVDFTVQGKVGSCGNCALGDAFRCDGCPYIGLPAFKPGEEVRLLNNDIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U958</accession>
    <name>A0A9P4U958_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U958"/>
    <dbReference type="OrthoDB" id="3787206at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121938" checksum="1392E40B27DAF103" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U979</accession>
    <name>A0A9P4U979_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_323983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U979"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="363" mass="40888" checksum="9A466D7A3CB10BF9" modified="2023-09-13" version="1" fragment="single">KPVPRKGHTKSRRGCYHCKRRRIKCSERHPECNHCIKAGLRCEYPANIIQTLQRAPSSPSPQEMVNLRSTPGMFTMADMRLFHHFLITAYPHLPVGADKIWITVIPSFAHNYEYLIHSILALAASHLDAVSSANVAEEAISHRILAVKALNDALSVPPKTGNERDARMAAALALAFQSSHLQDGLLEFLTMVRGCNLIALQGTLDNVDSAFYVNGHLATIRTRMCASQQNFVDLDDLDLAALSIHDIELLNMTDWEKRFWHALTQTVESAYDRPIQAYTTFVQLYNIPSQWTHDEFQSFIDPNNGVAQILLAHFIALQAVLTPILMLERVGFQGIDAPTSVLGWVDGIYKNVPPELRHYMEWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9B2</accession>
    <name>A0A9P4U9B2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9B2"/>
    <dbReference type="OrthoDB" id="10411333at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="251" mass="28110" checksum="747CA1FD488E99F5" modified="2023-09-13" version="1">MGIRRKLKSAFRRIKLRGHHDRNPFSTPQSPIRDVAAFYQHPNGQIPPDPIRPVKSYIRTRSTDIQEPLNFTYKSYTTPSGVVIPPDFSYDRPKEVYRVSGILPHNGWGTDMEFDGDEDTEMHGEMDVDSEVFDGDNEASDSGASQASTAPGFSFNTLARMTELALTAHQISHGRRFAHTVSPRPLPEVPEYAGRVHSPSPPRIRILTGRAVRRVRGLRIKSGDSKPSRILRIISGGEASSGDERPRPAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA55</accession>
    <name>A0A9P4UA55_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_521533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA55"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="390" mass="44531" checksum="96C4911538B28EAD" modified="2023-09-13" version="1">MAPRPMFTTTPMKKTSNEKHNFGAVIEGIDLEDISDSEVKALADAIWTHKLVIVKGQHHVRPIKQWELVTRFDPDAPLVHSHGDLKTFNKQGGLLSKGRDVYGVPGAENVRLIGKGYQGHDHFGLKGTTVRKEPGHAWHNDPLSDEEYTKGHTRFQRWHIDAPLYARDPALFTTLRCFKRPTQPNVTIHWDDASDHTITTEPGLTAFFSNVQMYDLMTDDERRIADHSWVEYAPHPYQWMGNCKSKSTGLGLVSQGKEKTFEDLSPYEEEDVKRYPMVWVNPVTGERAFMVHGICVRRAFMRSSLDEDAQVVDDVVEIRRWLSNIQERVLRPEYIMNPKVEEGDIIMWANWQMFHSAVDYPDHWGARTMHQANVGSSRAPVGPTPIPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA74</accession>
    <name>A0A9P4UA74_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_325349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA74"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="27"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="252"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2444214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="682" mass="76691" checksum="221B10C8A17DAAC2" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA85</accession>
    <name>A0A9P4UA85_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_360946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA85"/>
    <dbReference type="OrthoDB" id="3780024at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43627" checksum="50213A448860732D" modified="2023-09-13" version="1" fragment="single">SSFKNGFFDRSILWIEAVLPDGTITRASRTRNFELLEGMVGSLGTLGIATLLQIKLVPAMKWVELKYIPVRHVSDAMDTLDRLAQDPTSDFLEALIYGPGTPSYGVVTVGKLSAASHDPQAMFSTPDSEWFYEHALRAGESTESILITSYLFRHDRGSFSLGQYCFGRVPLNNWSRWGADSALRSHALAQTMQALHWDDHLFVQDLIVPSDSTLKMLEYLDSNLKIYPLLLPPVLMRPNQTQSNIAVNISLRGWTPSTINNPTAFKKTHRQIEQLLHQLGGFKWLYSHNYFTEDEFWETYPRKQYEQLRVKYHAKYLQNVWEKSETSERKPVSPKPKSLGSGVCEDRSGGYEPRAGPCVIEAQVDVDSVRSIALIGSDKIIYAGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAN8</accession>
    <name>A0A9P4UAN8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xanthine phosphoribosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_359978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAN8"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2444709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="202" mass="22775" checksum="16E90377DAD64134" modified="2023-09-13" version="1">MVEKIYVTYNQVHKLCQDSAQRILDDFKPQLMVAIGGGGYVPARILRSFLKTPGSPNIPIQAIGLSLYETLGTDPVEQPGTKVTRTQWLDLSSLEMANLIGKDILIVDEVDDTRTTLEYAVKELEKDVVEAQKKLGREGEKTRFSIFVLHNKDKTKKGVLPEDIVQGRYLAAQTVGDEWICYPWEARDIDEHDALSKAQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBG5</accession>
    <name>A0A9P4UBG5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_443208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBG5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040511968" evidence="1">
        <location>
            <begin position="22"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="209" mass="22668" checksum="4C84E1FF1B90CF51" modified="2023-09-13" version="1">MRLSAWAALSLASFWQCSILGHGNEAGEKLRCRLFRTCAGSHGLWHRKDGRNVWRANRPMQQRVVRIQETRRSGSDPAVADSVCNAQEDAHGCGKGRRSPSHNHVSGTVPGVGKRILLHCMAFGHGGQAGDLWRHGFPWAWPHSRTRAVYGTRHDQAALDARVGGSVLGVGRAPIWMGEPEDAWASARLCLSSAGSRPRIDAIAPAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBL8</accession>
    <name>A0A9P4UBL8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBL8"/>
    <dbReference type="OrthoDB" id="3773826at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040302223" description="Kazal-like domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8117" checksum="1E24F953834A5C13" modified="2023-09-13" version="1">MKSVLVYASLAIGTSAAALQKRIDPGCPDLMPTQASLPWIFLCTAYDLSYENACDRDGRTDRGYRTCESIGPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCB6</accession>
    <name>A0A9P4UCB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_485126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCB6"/>
    <dbReference type="OrthoDB" id="5345571at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="311"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="436"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="548" mass="62838" checksum="875FD29416426907" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCT7</accession>
    <name>A0A9P4UCT7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCT7"/>
    <dbReference type="OrthoDB" id="3793181at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="560" mass="61435" checksum="BF571C66DF64B4E9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD55</accession>
    <name>A0A9P4UD55_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tricorn protease domain 2-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_431209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD55"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="322"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="530"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="573"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2445820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="607" mass="64099" checksum="56E2D4FE671ECBE5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDB1</accession>
    <name>A0A9P4UDB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-oxoadipate dioxygenase/decarboxylase</fullName>
            <ecNumber evidence="6">1.13.11.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-hydroxyglutarate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_520686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.93" evidence="6"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDB1"/>
    <dbReference type="OrthoDB" id="8300246at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.80">
        <property type="entry name" value="Uncharacterised protein PF07063, DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="HGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479:SF2">
        <property type="entry name" value="2-OXOADIPATE DIOXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="HGLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="171" mass="19530" checksum="62D407875E543550" modified="2023-09-13" version="1">MAPSAIHSPRPSQQGFIDPDDLRTKFPLAMLAMYKKEVPLYGDLIKIVIAMRNGDVASKRLDLERHGAIRLRIPLERQTVRRIFAIIGLYPVGYYDLTPAGLPIHTTYFRPICFAALKRNPFRVFTTLLRPDLLEDAQSKNLALDLLSKRKHESLAQNSFFILRLVHSTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDC8</accession>
    <name>A0A9P4UDC8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_472950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDC8"/>
    <dbReference type="OrthoDB" id="5425653at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF185">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="359" mass="39576" checksum="2EB7592A545DD069" modified="2023-09-13" version="1">MASSPDSTVIVGGGIIGLSTAYYLARAQNCGNNISIIDIPNDLVSAASAKANGVLADYDYPPTVSDLGHLSCKLHKELAEAYDGKAKWGYAETVRHYLSLKKDGDGSRGLELKPQYKLPEWIRGREKYRDEIKGNPRNCARVDPRKFVTFLRKKCTSLGVTILLRSEVVGVQMGNEGVSAIRVRGPEETYDLQCRSLVISAGSWSERIVENLFPESLFKLNFDKTPLAGGNWLVLKAPRPSGDDYCHQVYVESITSAPVEISDYRDGRIYVGGYLGDAEPLPATPSDVNRKASGLPRRKTLPCNSSISASTGRRCWKWGGAVGRCWRLTGRLSQGYRWVCFAVKGMVQDRETERGVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEE4</accession>
    <name>A0A9P4UEE4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_355601</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEE4"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="144"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2447035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="422" mass="45141" checksum="1BDC79D279123DDE" modified="2023-09-13" version="1">MHPGPAQMGVPPSFSSRRGHAAHLGNFELPPPSAHKFSSFNTINAPQSSQAPTTIASVGNLLTPPNNIHGEVLSPSSGVSTSSAQPATMSSYNHSGAYMYSPASQPSSHYGYGGAPQNQYNQARGGEFLPCRIALSMLTDSRKGLNPPPYEMNQQLPPFTPSSVPSNMPPMSAQHQPHHMMNSQTPVSSSAPQQSPAHAQEPFRPPPTPTYGYPPATTPQQATFPYSTGPSPTHQSPISGGGPMPRMSPAVSHGAVPSIPSNPAQSPHPYQRSYGNYVPAPSPVYTNVNNPNGQLALVGGVHPGMMQGFNSGHAAAMPHFLGQHQHQQPPANDRPFKCDQCPQSFNRNHDLKRHKRIHLAVKPFPCTHCDKSFSRKDALKRHILVKGCGKAANGGDDTKRESHSPDVKAESVDTKTIIHSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEH5</accession>
    <name>A0A9P4UEH5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_452594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEH5"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="277"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="431" mass="48583" checksum="CDCC0292A9760EA6" modified="2023-09-13" version="1">MSDAPDAQGPDDEQIQRQKQINEEYKMWKKNSVFLYDMLYSRALEWPTLTAQWLPDKRPVEGTNLSTHRVILGTHTSGQAQNYLQIAHIEVPDMPTPDPNNFDEKTGEVGGYGDAKKPFDFNVVQKINHPGEVNKARYQPQNPEIIASLCVDGRVLVFDRTKHPMDPKSDGSIKFEAELVGHENEGFGLSWSPLKEGHLVTGSEDMTVRTWDIKSGFSKGNTSIAPVTTYTTHTSVVNDVQYHPIHGFLIGSVSDDRTWKVTDTRVQSHKIALYSKENAHADALNSIAFHPEYESILATGSADGTIGLWDLRNFDKKLHSLQHHTGDIIELQWHPQDPAILASSSYDRRICMWDVTRVGEEQTPDEAEDGPPELLFMHGGFTDRISGFDWNKNDPWLMLGTAEDNQMQIFRPSRKLVEPIPKATNHGEVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEL0</accession>
    <name>A0A9P4UEL0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
            <ecNumber evidence="17">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P171DRAFT_428977</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="17"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEL0"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040230386" description="Endonuclease" evidence="19">
        <location>
            <begin position="18"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="21">
        <location>
            <begin position="96"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="20">
        <location>
            <begin position="97"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2449029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="338" mass="36860" checksum="A3B63D8D7A57E217" modified="2023-09-13" version="1">MSKVTLAIVAATGAATGAVATAALWSTKKESPATVVTTTTTTTGTGTGTGTGIQRASPPPPLPVGRHPHAAPQQALVDPSGIFQYGFPGPVNDLRPAASLTSSFDRRTRNPHWVAEHITPESLANNHADRKHSVFVEDVAIPDMFRAKLKDYFRSGYDRGHQVPAADAKWSQEAMDDTFALSNMCPQVGDGFNRDYWAHFEDFGRRLTKSYPSVRIVTGPLYLPKKEADGKWRVSYEVIGSPPNVAVPTHFYKVIFAEDGRQGGNVALGAFVLPNARIANNKPLTDFEVPVEVVERASGLEFAKKLEPARRKRLCQEVNCSVVVKEYAQRQKSFGKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEN5</accession>
    <name>A0A9P4UEN5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEN5"/>
    <dbReference type="OrthoDB" id="2279190at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="96" mass="9971" checksum="25313C94D69F1939" modified="2023-09-13" version="1">MSDTATRPATRPAGYMSDSDDGQASGGRKVSANVSTYPQAPSSSSLNRPAGSIVKGPVDDNGKLKDAALLLGIKLDLEAEIHLTARIRGDITIGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UER0</accession>
    <name>A0A9P4UER0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_430616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UER0"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000029">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000033">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="464"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="527" mass="57226" checksum="512751964E517266" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG39</accession>
    <name>A0A9P4UG39_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_481226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG39"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="361" mass="41461" checksum="9AF95796B1E0ED21" modified="2023-09-13" version="1">MAAENPAQSIATSALQPPFAPRPIPPKPTVTASHASLFNGAADYGQQPVLDSATNIPLTDLESLPTLTGDPYEPFLANEDIKKFLAIDLDLKRLNRIHGHLWMCGRPMRARALHRYKMLGMEALPTTQMDLHLLRFSNKLMIKPLGEYMLSHSFWLDYLCDCEELHKAACGFLLSYIWLLTTPLDLKFAHELFLIPSFVTWHWWKSFVADFTNIIDIKALDQVNKRFHFGDLRLGRINSVYRIRYAHTHFVRGYLYGYNRYVVFFQRKFGWILIVFVFFSLVLAAMQVGASVDPLQQNNAFLKSCYGFVVFSMVSVAAVLGVIGALFFFIFFFNMVTAIGQAKRWEIKRVKMAEERRIKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGG5</accession>
    <name>A0A9P4UGG5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_213967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGG5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF102">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="335" mass="38145" checksum="E6F6D5A65B0B60FD" modified="2023-09-13" version="1">MSDTHVPEAEVSNALIPESDDSSDADSAVGGLTYASSTTSARSDVYTSVEEFGRTYHGYKSGKYLLPNDEKERDRLDLQHMLFTISCDGALALAPIGKPRRVLDIATGTGIWAMEFAEQYPDARVTGTDLSPIQPSYVPTNCQFEIADAEDEWNFSRPFDYIHGRALLTCFADPRSIIQKAYDSLTPGGYLEFQDGLFPFQFMDPQPPPENPLRSFLETVAECGTKIGRPWTNVQHYKRWFEEIGFEDVEEKRLYWPCGPWAKGDKMKKLGIYFMEDMKHAFEPVAMKMFVKILGWSEEKTKKFLDEEVMPLLGARKTYMYETVCFTYGRKPLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH07</accession>
    <name>A0A9P4UH07_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P171DRAFT_452503</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH07"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="45"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2448792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="377" mass="40820" checksum="D7D81D81661AEA39" modified="2023-09-13" version="1">MFRTAPRRFAASLWRSAESIQSEAGYQTSINISKAQGIGQRGFLDAIGKTPLIRLKRLSEETGCNVLGKAEFQNPGGSVKDRAALYVVENAEKLGLLKPGGTVIEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPQNYNHQAKRHAESLDNAVWTNQFDNVANRQAHIETTGPEIWYQTEGKVDAFTCATGTGGSLAGVTRYLKEKSDGRVKCFLADPPGSVLHSYIQSGGKLADRAGGSITEGIGQGRVTDNLKPDIDLLDGSLHISDEKTIEMVYRCLDEEGLYLGASSCLNVVAAKEVAEKLGKGSTVVTLLCDGAYRYADRLFSKKWLEEKKLLGAIPQHLTKYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH63</accession>
    <name>A0A9P4UH63_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_428931</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH63"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="8">
        <location>
            <begin position="172"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="339" mass="37600" checksum="E34F67D00A84C13E" modified="2023-09-13" version="1">MEITATVVDAFASFALDSSSFALPLAVINRGLQALSPIPYPKDSQHSFQQALNQLDSVLSPKSTLYLTLRHEGSFVAITFIPYAANADDKALLLDNRQALVKALGEHQFSSSILCKEIGEITDARSWDERSGKGQSWTGNSSEYIDACEKGDPAVNGVHDLGHKKNKCRLCDRRMKNNIDDGALDALKSLAEGGDCVQLNSQQSVNISTEVLQLNFGAKNLAPVEVISRLPTDKPSFTFYRHGSNDRLYFIYCSPDSANVKERMKHTVAIPGLINIITKDNGVNVDQKLEIHDPEEVDFAQKDERIGKFRSMYLRNKFSGTESQWEGMEAQQKILDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ70</accession>
    <name>A0A9P4UJ70_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Leptomycin B resistance protein pmd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_403857</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="905"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="929"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1045"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="78"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="404"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="784"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1105"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="469"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="725"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="738"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2451027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1347" mass="147495" checksum="07F59D6BEEED5F85" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJW1</accession>
    <name>A0A9P4UJW1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_426498</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJW1"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.960:FF:000002">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2452108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="660" mass="75251" checksum="E18C05205BFF6E94" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UKB4</accession>
    <name>A0A9P4UKB4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UKB4"/>
    <dbReference type="OrthoDB" id="4158609at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="107" mass="11746" checksum="57760751161DFEF4" modified="2023-09-13" version="1">MPSPFHQKYSSQTHKAFGDNTVPIMPTAPKQDADRRPSDSSITSNSGSPTSERRRSSVSKFANLEALKRPQDESSVNRRSSLQDSYGKVGVIGTMWNNFTRGPSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4Y4</accession>
    <name>A0A9P4P4Y4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P171DRAFT_437609</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 20"/>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4Y4"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="291"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="341"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="381"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="404"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="429"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2437521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="545" mass="58188" checksum="463AD8E3B0FFA404" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5G0</accession>
    <name>A0A9P4P5G0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_449861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5G0"/>
    <dbReference type="OrthoDB" id="3937782at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="345" mass="37788" checksum="83110CCA42D8974B" modified="2023-09-13" version="1">MFVVTPVAMAHPYSCPLTFTFDMEDHILAPLRDDQKIDFMWRTAIALTHKRAFVVVFYGRDGHEGKVCDEVKISDGLSYNNIKQWTSNSLVLSGTSTSLLFQTMIALSNKIPFYNRGLTKNSIGRLVVYHMQKGVGKMPSMSASVITYKMLHMFISMWLSVSEAYANAPPSLPIALYSQFHNAVAGKGTRCEGWDVGGPPKKKSRFGAAMKDRAVSTGDTGSRAGFNAPQTPANPVTGFSVSGRIVGSVAKEPKWSSEEPQAIKNKRALEHRGERQVQDPQQTYVRKNPNGTITGHSPKSVPERVHACDRGCEGRLGVAAGHVLERHHRGQEQGLDVEPMGGSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6A4</accession>
    <name>A0A9P4P6A4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_372413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6A4"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="208" mass="22280" checksum="E83A1AF26BB25808" modified="2023-09-13" version="1">MSSTPPTDPTSPSHYPPNQTALLLLDFHTLFVDSLPAPKGHAALAVAASTKKWAKSTGIHVIHCLIDTEQTPFPTCKSIPRWTSIADSFKAGGGDEPAALREDAHGERTFLRRAGYVSALKSPGLVEYLREEGIVSLVVTGLSTSGCVLRTAAAACDDEFVVTVLEDGCADGEQDVHDALVKKVLLGRGYVYTAEAFRDGWEKRTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6F7</accession>
    <name>A0A9P4P6F7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_167789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6F7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="163" mass="17632" checksum="C9BA0C8A07DAADBC" modified="2023-09-13" version="1">MVPMFLLYAFGRNSGSLRSVIRHQTLPGPAMEALVECVQLTGQCSSTCATSTLVGRCQFPWSPITIRVYGVPHNAPACSGNHNHTILTVRHLSLMGIPPPLPDTSVPNPSHLRAGGIVGQSPYLQPLHIRTRASLRSYHAILVWSTILCTCRVHCTTAPVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7A0</accession>
    <name>A0A9P4P7A0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_437450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7A0"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2437834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="90" mass="10275" checksum="2CF8DE6C968D5BC9" modified="2023-09-13" version="1">MPSAKFNEVYKQTREIKTGPSNDDLLNLYAYAKIAQGEDIEKAPKPGMMDFTGKAKRKRWQEVVDTKISQADAEKKYIELGESLIKTHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7U0</accession>
    <name>A0A9P4P7U0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_447960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7U0"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="754" mass="85268" checksum="8313C609435C0F96" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7Y2</accession>
    <name>A0A9P4P7Y2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_449340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7Y2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="169" mass="19557" checksum="29EA48BF3935A36C" modified="2023-09-13" version="1">MSITFNDMAKTKAFCLKIRQFCEDCRPDTCKQVASEIQAHLDAIDQTRKEYGEAKEGLIQALDVPRWDDNYTEDRYWLKKYEPLYWGEDRDPGERAKAFLEIMRKMVRLEKTSVEFQKGLDAAYKGLRKVADDVHGLILTKIEGGEYGQADKEGDGEEDFWKDIPEFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7Y3</accession>
    <name>A0A9P4P7Y3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_502210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7Y3"/>
    <dbReference type="OrthoDB" id="3778650at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="431"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="489" mass="54320" checksum="497C5C502BDDD7C0" modified="2023-09-13" version="1">MDSQPPPGTASNPTAASMSAPSGVPANAVRPSMPQILQQMNTKGFHDFLVGRLHNLDLRGWPLHLRSMETASWRLEPGVPWAPEDQESLLVLSAHGVKIEDIARLFFEGRTVDECQAEIEKFKAGVPMESIEEIGQRSEGDIESSKAALPETPSTRAVLAVPSSTPSVATSFTKRLIEVSSSASRARSNKPYTDSRKDWDQADRDTVWAAVQRGLTPREIQAQYLPFRSESAIQTRMSKERALRGMQAAPTKWSNKDTNLVLKLTSEGHDFEDIAPRLSRERTPQQIEARYRNLKKQAKASRMSVEANLIENDDGDVEMGEGEGEESMQVDAAGDDGSEYTEDSPQAVQTPPKLRTARKTVTSTSDSLSKDSLKKTPLSIATIRTRLLGSIDAKYLSSDDKKELRKALNKTGWPTRFTSVEEYNSPLPAKVGLRWTEQDVEALRCIRESVPSLPYKFIENFFPGRSTTAIRNLYNTKVNPGPNYNGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8L4</accession>
    <name>A0A9P4P8L4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_501451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8L4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="199" mass="21694" checksum="AD60112D44F1770A" modified="2023-09-13" version="1">MYIRIEPKFAAERIASVWRSPKVHYIPDQKAAGSSRGTCTIAETGGSQCETRQLHNPLSHPTVSMAARLAQWSSVHRSDHCECKADQKPPCPAQFTHQSPPPSPPQPPTPRPTPPISSTRNPYTSSNPSASPSPPDSRHIVKHTPPVAPTISTIRTFQKSVPRPLRLYEENLASSAFCERGVSVVLSMYAVQDGRQGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P983</accession>
    <name>A0A9P4P983_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Auxin efflux carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_436216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P983"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF4">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2439572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="49851" checksum="274B04AD0D0AB5C2" modified="2023-09-13" version="1">MASGLLSSFVAAIQASLSVLLVISYGAIAAHLGLLDSKNGKAISKICVKMFLPALLLVQLGSEMHAGSAHRYLVVVIWAVLAHVVSFLIGIAAHVLFGMPDWITCAIMFNNTTSYPLLLVQSLDQTGILRVLMAKDDSTGAMVERAKSYFLVFSTISSCLTFAVGPRLIDTEHAPDSDEEDRGSSSSSGMLTEADEGTADVENGEEPSERTGLLRAPASRRRADRARHASVASITFFPSKPTFTTVKRRPRYIPHLRWSELDPRTKWWLLFFYDFLNAPLIGAVLGAIIGLVHPLHKAFFSDMTEGGVFTAWLTESFKSLGQLFVPLPLVVAGISLYSSYQETRHASGSSQVAQVPLYTTAFILIVRFVVWPVLSIGAIYGIAKSEGKGGLLGDDPMLWFTMMLMPTGPPAMKLITMIQVSDAGAEDEQRMAKILTISYIISPILAFTVVGALKASEAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9Q8</accession>
    <name>A0A9P4P9Q8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_113884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9Q8"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="158"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="230" mass="25673" checksum="0CA2F7CF9C4C6F81" modified="2023-09-13" version="1">MLFQRDQHADVDGRRGSRMAVIENFKNFLRHGKQARGNAAPHGEPTTNVSNVHAQHQPQRHNNHPEPHHAGISEPVMHQAHKEHVVAPHGDFSVGAVGNRNIAAKAGDVAARAAGDKQKQEAAAAKNRDIDPTVLERIVAEEREAKGKLPKYPGLERWKLVEKMGDGAFSNVYRARDNDGQHGEVAIKVVRKFEMNSSQVSMPRWNYPVIPISFYLHPPPRITDLRVVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9T3</accession>
    <name>A0A9P4P9T3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase-like superfamily-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_456952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9T3"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="165"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33409" checksum="C5A6226C4CCD23AA" modified="2023-09-13" version="1">MPSWKEATAVRKVGASTYECTLQDDWCIGTVPNGGYVTGCFIEVVSAHFATALAKQNQPHTIALHIEFLRRTQVGPATFHVEDVKLGRQTSVVHVRMSQEGREEVLAYATNSNIDTEQGVSFDTEYKLHPPPPSVVLSQLAKDEDKNWHLEDDMPFANFRKATRQVKFHFPRNGQIKPSIADEWLCFRDGSNFTNSSIGFVADMFPLIIENYRGHGQGPFWYPTLLLNLDVKKSLPPEGVKWLAIRVQTKKVMNGRMDLEVHVHDEQGDLVATSHHVAFVLDVARNTAARSKPDTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA35</accession>
    <name>A0A9P4PA35_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_97940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA35"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="460" mass="50735" checksum="F707949E719EB91B" modified="2023-09-13" version="1">MGSATEWSPSSWQSKPIKQVVTYEDQTAASAALSKLSSLPPIVTPTEIIRLKSSLRDAALGKAFLLQGGDCAELFSYCADDPINAKIKLLLQMSLVLIWGSNKPVIRLGRMAGQYAKPRSSPTEIVDGKEVPSFRGDILNGFETSQRHVDPERLVTAYFHSATTLNYIRGQLTSGIADLHNPLDWDLGHVQDDELQKKYSQIVSNISESLRFMRTIGADTSGQLQTVDLYTSHEGLVLEYEQSLTRKLKHPAGYQSSLSNDGKGWYNTSAHFIWIGDRTRQIDGGHVEYFRGIENPIGIKVGPSMKNDELVELLDIVNPNKEVGKVTLITRYGKDKVESMLGPHIEAVKKSGHVVVWQCDPMHGNTHSTTAGIKTRSFNSIFSELSSALKVHKEHGSFLGGMHLELTGDAVTECTGGSEGLEEADLSLNYTTYCDPRLNEKQALELAFLVAGHYREDNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAF6</accession>
    <name>A0A9P4PAF6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_71457</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAF6"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001834">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="33"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="236"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2441400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="483" mass="55065" checksum="947986706ACE32DB" modified="2023-09-13" version="1">MPGTNKRPHYDLEFTLRRVFGKREFRPVQREVIAATLHGEDVFLQAATSFGKSLCYQLPAVVDFGITIVISPLLALMNNQVASMRKANVRVETINSTTTAGNKKRINDDLQCGHPLTRLLYVTPEYCQLDSFRRLLRVVHSQRELARIAVDEAHCVSEWGHDFRPSFQQLSWFKAEFPDVPIICLTATATARVRDDITTTLGLDASKLKMFRMSTSRPNLHYEVRFKSDEKDHYNDFVRWLKHIHEKRAAPERASQLASQNQRPDNWPGIIYTLFRKDCESLAARLRSDGIGAKPYHAGLPHTERADALAGWVANKEGYDVIVATTAFGMGIDKENVRFVVHWQIPKSFEGFYQEAGRAGRDGKASSCILYYSREDRDRALTMLARDQQRQPKSGAVSAQQAQLRHRLSSMQALVNYCEGTTKCRHKMIANYFADDGETPCGMACDWCRDARALVRKKEAGLASEEWVSTQRDLGRYNMDEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAP9</accession>
    <name>A0A9P4PAP9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_525407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAP9"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="214"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="737" mass="80466" checksum="0020FDFBA677F3E3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCY5</accession>
    <name>A0A9P4PCY5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_77194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCY5"/>
    <dbReference type="OrthoDB" id="5966927at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="499" mass="56241" checksum="3C2E7F5FA4B6BC22" modified="2023-09-13" version="1">MHASVQSPFCERCEKNQLIVNRSLAEYLPDEDDPQYAKYEKALPQYQAQLEERYPPVCENCIERVQAGIRQAGYATKAEELRRKLDQSKKYQKETPTVRQTCTLWIIWLGKWSYIISAIVGMLWHSLGAIAYFDFSERDFDWALCLSEATYMREVHQSCVASSSVRQVVFYALVADLLTVWWNPKLGQKMKHANGRMRGLVITWMIRIVLLSLNAGSYLLLKDASIRESGIISDESVDFFRYTHMVLLTVNILAALLAWNTVTIKYVSTKELLRPLDAHLPTAPRSTQTTPRQQRTVPLPDNTSFDSMAAGFASSFPSELNAYPPSPTLTATSYADTEESDFTPYTARKSSIATNASTDAMDWTPTPSRFAPHTPSLLPFPNTQLQPDSPSPSPSKPPVNIFKAGADANPFRRRIPAAPASWHKSALPPHPEERKRNFFEEDREKNRDLGLGLRGRGVPKAVEKEALLFRAPQFKYDAGGYVGGKETGLEEGFNDLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD85</accession>
    <name>A0A9P4PD85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_488421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD85"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="42"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="293" mass="31069" checksum="6ABC3D0F6AF65512" modified="2023-09-13" version="1">MTGMNTPGTPGIGVEPLNTPRLQRNPTGYFRVPLATHRLANKVAFITGGGGKVGVETAARLIREGANVTLMDVSWDALEQALATLKDALFTGEIASSRVLTVVGDAAKEKDVIDAVERTLKMFKRLDIAFLNAGISYQPTPLLETTEERYDEVMGINVKAAFLGLKHVGKAMKALQNGGSIILTSSIAGLRGTPGLSVYSASKFALRGLALTAANELGPDGIRVNTIHPSGVESPMFREAWTDAQLEEMKAGIPLGRFAQTHDVSSVVAFLGHEDSKFITGSAVKIDGGCLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDN3</accession>
    <name>A0A9P4PDN3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_465642</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDN3"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd06006">
        <property type="entry name" value="R3H_unknown_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16492">
        <property type="entry name" value="RING-CH-C4HC3_NFX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000006">
        <property type="entry name" value="NF-X1 finger transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034077">
        <property type="entry name" value="R3H_FAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="13">
        <location>
            <begin position="838"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1109"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2441056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1150" mass="126731" checksum="D5027558233B5ADA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEB3</accession>
    <name>A0A9P4PEB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_96913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEB3"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="117" mass="13045" checksum="D45E31422C6B8B04" modified="2023-09-13" version="1">MSTATVPYTLPPSRLSKPIIACGIIMALSASRRFSAFHGQLLSQSPTLANVAYWLQTGIFWFFYGAHTIESALFAKKLKDHGVSVLSAAWWVWMVECFIGGKFCFEHFEGIVKIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEV8</accession>
    <name>A0A9P4PEV8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 16">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P171DRAFT_474927</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040439093" description="Vacuolar protein sorting/targeting protein 10" evidence="19">
        <location>
            <begin position="22"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1355"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1406"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="20">
        <location>
            <begin position="48"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="20">
        <location>
            <begin position="709"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="647"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1015"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2442617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1474" mass="165663" checksum="EA43207A264189EA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFD7</accession>
    <name>A0A9P4PFD7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_487282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFD7"/>
    <dbReference type="OrthoDB" id="4497263at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="149" mass="15585" checksum="80FE89E4A25291AF" modified="2023-09-13" version="1">MSVTAETNGDDVTSWIPLTAVFTPSSGCESAFRLNGSSLVAFDPGYGLDIDPAVKCVPSAVTTWWEQARLGVGGSEHTALSIQPLTCPYLWTTVATFIKDSTTTQIMCCPSGYSNLHATSRSVNGDCLSSVSKGMVLTYASTGAGESTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGB7</accession>
    <name>A0A9P4PGB7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_50600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGB7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="114" mass="12356" checksum="C508182128DB6B2E" modified="2023-09-13" version="1">MSFPISHNVSHEVCHYPIWGGYCSSCDTRAASIRPSGGEMMWDAGRAKGPAVRCTAAFRHRQGGEAGYWLADASNRLITCRQGGGVNLHFIGRGTTLDLHDNVSQQLPRLEGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGC9</accession>
    <name>A0A9P4PGC9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_455694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGC9"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="162"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2442653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="275" mass="29978" checksum="D195B4FF52688C2F" modified="2023-09-13" version="1">MSTQFSGAAVAVTHNPFQHAYKKSALYGQMDSGSNTPMNVSPTSPRTMSHLPAYPQHAPALRPLKTPGYIPAALRRTEKPGGRSPPNADSASDTPNTSWGSGSGSGGSSGQTPGDLTPVSRIATEDMRSIYDDTPLSPVTGPITRNHWQPDSSTIVCTASCCQQPFGLFMRRHHCRKCGGIFCYQHLQKQVRLNEQALFHPEGELHKACDRCHTQFREWEQMRSSRTNSESSGSIDSPAAVQIEQPLQAKRPECAPKASFLSQSFGGGTWNWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI18</accession>
    <name>A0A9P4PI18_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI18"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040487181" evidence="1">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="72" mass="7925" checksum="B64BB74098A7B2E9" modified="2023-09-13" version="1">MRFQALLWLSIATATATATALPVLALRQLSSYGRYHSYGHYDGSYGEYPSPPLEAEMERVKGADETNSQEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI41</accession>
    <name>A0A9P4PI41_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_414530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI41"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2444465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="535" mass="58260" checksum="D72478C98D09CF19" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI85</accession>
    <name>A0A9P4PI85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_432510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI85"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="55"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2444482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="38328" checksum="6823C92A7F2D379A" modified="2023-09-13" version="1">MQRDDSEQLSAILDEEKDNVEPNRPLLGNEKKMADSESQVPRRMKEQDANRTRTIAYLGMYFMMNLSLTFYNKLVLGSFAFPWILTAIHTGTSALGCSVLLLLGHFQLSRLSLREHFVLITFSLLFTLNIAMSNVSLEMVSIPFHQVMRATTPVFCILIYRVLYARSYTPAIYASIVPVIAGVGLATFGDYHFTALGFTLTLSGVVLAAVKTVVTNRLMTGRLKLPAYEVLLRMGPLAALQSLLSSVLTGEFAGFLTYVRQGQLDGGRFMAVAGNGMLAFALNVASFQTNKLAGALSMTICANLKQCLTIVLGAAFWNIRMNAVNGAGIVLALLGGLWYSSIEVRGKTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PID4</accession>
    <name>A0A9P4PID4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PID4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="179" mass="18359" checksum="CB65E861A3833510" modified="2023-09-13" version="1">MVRASDGNWQPQPGPMRPAMLQTASLPLHGMFCSERQGSGGSSGCGAPIGGGKHATRVSISGSSSPCARLGCESDSPVPFATRRVAWGDGCERQPSRGQAVHRTRGRGGGISEVAATPGLMRTGCQECVPFVITSPPMSASVRRGLRGRGRGRGRGQEKQSSAPAAAEAAADRSGTMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJN2</accession>
    <name>A0A9P4PJN2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_432446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJN2"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32333" checksum="C890C581D3870FF6" modified="2023-09-13" version="1">MSTKAALKAAKAAIDAKKWDEAIEQANAVLAKDPENYFAKLFIGRAQDGLGKLDSAAQAYNDATKIKPQDPQAWLGLRGLYQKQGKAKVDERIDVELQLAQIYAELDDAHKAQTAIDSLVDHARKYGTKQQYARALATQTPTSPIYSYLEGRLPQPAAVYTRLAEIYEGEETATIKHQIDERRSRLGATLEGTKTEVKNEVYGSSPLEDIYQNIVDWTGDDTLRREYEEKLLQRAYDTLLVLPAGKKDAKREKVIKLAHDMVIIRHPYPLAWQIELEWRSGLAVEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJX4</accession>
    <name>A0A9P4PJX4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_267348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJX4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="126" mass="13622" checksum="CD3D0A9CBB094C43" modified="2023-09-13" version="1">MMHAIPVESSPPIPLTGMHPDASTGSACHPGGLYAIVACQARAHMLPSTARAHIAQPRLRLHVPPSFTFSTAILYISCFILGFRLRIAPLHCMRYHFIATSSSYLYNFLSPRIYGAGCISRGPGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL21</accession>
    <name>A0A9P4PL21_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_429987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL21"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF49">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="29"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2447055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="292" mass="32126" checksum="774AF88A78090DE7" modified="2023-09-13" version="1">MDRNAPEYICEQSAAVSLRETRDCVAHIRQLAGCSDPKHALVKPILTPRFAICCTSELLRGLGDMMKTDDDLAMQTHFNEAQQEIDATRELFPKLAARSEADLYESFDLLSRRSILAHCTIMTDYDKDRLKALSCGVAHCPIANMTVGGGFMVAPVRDFLRRGIKVGLGTDSGGGWASQMLSVIRQTMIASNAQEVMSQGEDKGFTLEEVFYLATLGGAQVMCLDDQIGNFQVGKQFDASWIATTTGLQSAMTPREEGDSVRTILEKFVMSGDDRNIAHVYVRGRRVAGSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLR2</accession>
    <name>A0A9P4PLR2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_471909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLR2"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="345" mass="38380" checksum="3BB430C4B211FAA4" modified="2023-09-13" version="1">MSLPAIDFSAFRNGTEQERRELATRITGEFKKHGATRLISHGITGEITLLYGDKFFQLPGAEKVAIANIRDANPQRGYSYVGSEATSKVNKKDQKGEFQICEDDDVDQELVDAKEHFDYTRDGDEYSTPWPSEASIPGFHDWMEGAFLQDCMRLARDVLTAIEIGLDVPVGTFTSCMESHVDELRIQHYPPLAVEELKAGKIKRCHPHTDFGFITLLFQDATGGLEVEDRANGGWLPVIPIGDPTEVGVYIGDTLVHKTNGHLRAAVHHVVAPVSLKNREDGIMPERFTIALFAKADRHADVGPMSQFITSKTPQRFPNLTALELHNKRVGQLYDARPKAHMASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMD5</accession>
    <name>A0A9P4PMD5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMD5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="109" mass="11679" checksum="5960F15C8EDCA759" modified="2023-09-13" version="1">MLKVVASILLAETAPNLAARTCFGLLFEPNAKLACGLELLQALHCRGVLSSSLTAELSALTLGLSCGSPTTPGWCLVSREERALPRPTAGRMERNRQWDDNEAGLVKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN39</accession>
    <name>A0A9P4PN39_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_257082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN39"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="195" mass="22554" checksum="4148BF44BA640FEA" modified="2023-09-13" version="1">MGKGRVRIPPSFCFCSLRYFAATSSAALWRMPKEVAGCLPAMYHLFWPLASLSRLSYLFLLVQDEIIPHSNLWQFLFVLQISALYWTPQRVLPRPEFEQQPRPKQAIYFLAIFLFRGTTPTMCSFRTATTTHRRLMSSEGCFLPSYAPLNLTAILRQLCNLQDVRNTNLRMLHHPPLYIRLLGQQDLHPGRVPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNB2</accession>
    <name>A0A9P4PNB2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_247789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNB2"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="32"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="186" mass="20758" checksum="760C3202091AD518" modified="2023-09-13" version="1">MSLLTPVTDDSMPLFSASLISPEVQSQLPEGYKMRPLQRGDYAKGFLDVLRVLTTVGDVTEEQWNQRYEWLTQHNDQYFMLSILDPASRVVGTGALIVERKFIHNLGLVGHIEDIAVAKDQQGKKLGLRIIQALDFVAEKVGCYKSILDCSEANEGFYVKCGFRRAGLEMAHYYGEAKPKGGAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNL5</accession>
    <name>A0A9P4PNL5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNL5"/>
    <dbReference type="OrthoDB" id="5386682at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="193" mass="23009" checksum="C5E6BE659CB606C1" modified="2023-09-13" version="1">MYPADLPQRPQTFKDTPEYRCLSYTWGEPPEDHRILVNEHIFQVRKNLFEFLELATEVYPDEPLWIDALCISHINTQEKSHQVQRMGTIYENATEVVVWLGKRLTDERMWSKRGLRSFLETRIFSRGWTWEPGLCDGMLQLSRQYGTEYVVRAICEHPYWTRAWIAQEILLQDNIVILVGCEKIEWDRFGQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNU0</accession>
    <name>A0A9P4PNU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_483651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNU0"/>
    <dbReference type="OrthoDB" id="3671334at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="60134" checksum="ABC2B1AFA5643E93" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP16</accession>
    <name>A0A9P4PP16_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAP2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_429367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP16"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000042">
        <property type="entry name" value="PAP2 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="110"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2447751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="388" mass="43211" checksum="A351B0FC7C9D23CC" modified="2023-09-13" version="1">MNLKSLHMPSKRLILSYIFDWIVIIGIAAVGGGWNFIHPFNRPFSPVDLSISFPFEQHETIPTWLLMVIGLVIPALVTFLVCLIFVPGPTAARGTPQSLIWRRKFWEWNTAWMGLALSLATSFMITQGMKLLFGKPRPDLLSRCQPDLDRISDFSVNPVATGYNPYWVLVTSAICQNTDQDVLQDGFKSFPSGHASFSWAGLLYLTLFLASKFSVAIPFLPFRPFSTNPDHVSATARSNLKNRSILPLNTKDSNLSSYTDDRVVPDRYQAAAPPVYSLILILVPVGTAIYVCSTRFSDYRHFGFDLIFGSLIGITTAWFSFRWYHLPITRGAGWSWGPRSYKRSWGIGVGVGSYVGTEGWSPYGKSETAGTNGQGTLVDDRAETGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPJ6</accession>
    <name>A0A9P4PPJ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_429621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPJ6"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="278" mass="30977" checksum="DA27CAD397DED85B" modified="2023-09-13" version="1">MHRHAGYQYAAAPAAPTHRYSGTSSAFSASANPNEDWTKISDLAERRRIQNRIAQRNYRKKLKKRLEDLERRAASSSASPEQKPAELQPTQPSARQPFPSPASSESDFSRRTPEMHSYEERGMFSHQYTDRQLSTSPPPFSYSAYPTPESAAYPVPYTTTATPYHSIPTTISPEMTTYAYLPPLSAAYSTTLPSLAPPMKSEYYQEDDIANPFASGYQLMNSMEIPPPHAYPPSDAHTPPLLSDSFETSQANSPPEMYQPTTPDSMPRTPPMHPVPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPS6</accession>
    <name>A0A9P4PPS6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_509491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPS6"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2449065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="380" mass="41891" checksum="E73D1D0A8E720C3A" modified="2023-09-13" version="1">MSSSISAGLMAISTITTVIYGGLHLLLHLTQDAREPPPVPASVPFVGPMIDLSRKKSRYYAALWGRYKLPACTIRLPGARLYVINATSLIPAVQRQYKTLAFPPLQAKLAMNVCGSSQTANDILNTNATGDEGAYNRRRSSELFDFVKREVTLATTDSVYGDQNPFRDPAIFEAFWSAQICGYFKEGGHEGGSALIKARYAHSMSHKISVEDIARFEIAGAIAILINTSPTYFWQVYHLYSSPSALEDCRRELGTILSETASKTQGGRSGRTVTLDLTQAKTSCPTLLSSLQEVLRLHSVGISTRQVIEDHDAVTWGKDIHSFDHRRFLPNEKRPNSVPRGFGGGTTLCPGRHFASTETFAFTALIILRFDMHSVGDIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPY1</accession>
    <name>A0A9P4PPY1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_482725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPY1"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82061">
        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="78"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="226"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="567"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2448037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="787" mass="86839" checksum="D5ABA0C603C4480C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ28</accession>
    <name>A0A9P4PQ28_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maintenance of ploidy protein MOB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_429763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ28"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="220" mass="25254" checksum="FAA894F8DFA699DF" modified="2023-09-13" version="1">MSGFISTINPRTQRQPFKGQKSGRGTSSWQLKQYAEATLGSGSLRKAVKLPEGEDKDEWLAVNVIDFYNQINLLYGSITEFCSPQTCPEMKATDEFEYLWQDNEAFKKPTKMSAPEYIEHLMAWIQSNVDNEANFPSRIGVPFPKSFASLIRNMFKRLYRVYAHIYCHHYPVIIELGLEPHLNTSFKHYVLFIDEHGLASGSKDFWGPLGDLVESMLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR73</accession>
    <name>A0A9P4PR73_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_429393</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR73"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040136753" description="superoxide dismutase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="10">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="261" mass="26351" checksum="A9DF2E44F020492E" modified="2023-09-13" version="1">MRTQSIFTLLAVASAVAAEDAPVVEQNPIGAQYEALLDPTKHWGVSGAVKIASGAAAKGVTVEVALANLPSEGGPFIYHIHEKPVPADGNCTATGAHLDPYKRGEVPLCDADNKETCQTGDLSGKHGNITTGTSFSAIYNDEFLATLTDDKSYFGDKSIVVHLSNKTRIACANFKQLSPGNASTTASSFGTSYGTALPSGSASQGHNATASATPTGSTGAPIQPTASPTANPTNTPPGVGAAGKVAVSGAALFAFAAAMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR98</accession>
    <name>A0A9P4PR98_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_225294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR98"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="111" mass="11885" checksum="187A33F07A5DE687" modified="2023-09-13" version="1">MLLERNLERDELLCSSSMAAENIARTIRGRAGPLVHAATRTEEAGVGSIEMRANMYAVAFGPARIQHCAKEAPLADRRSSDSCKSLRDDGRACGTAPAEPALGGKQQRVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRL4</accession>
    <name>A0A9P4PRL4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_407169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRL4"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="509" mass="56132" checksum="E5DAA9DD331D6D23" modified="2023-09-13" version="1">MVITTTIVGALALAVAIGAFLSIASRAKVDAREPPAIYSPIPFFGHIIGMLREGPLYIARISAQSSAPIFAMPMLGGKSYVCKNPQYAALIQRATSTLDFDGIVVNMTPRMVGSHAKTSRILVESQELMKRSHGIINPPLSQQHMGSIAAIQLAHFGDFINKIQNGHEVDLFRFITREVTAATMRSFYGPRNPFAVDPSLIEAFWDWEWEIVAYMVGVMRSVFARKAQAGLERCVKGFEKYAAEDGYKDASGLVQNRKALHEDFGISPHEHARLELGLCFGFNSNASITTFWVLNNIFSRPPLLAEVRAEIERNAIVSPGTIAFTKLRDNCPLLNSIYKETMRLAAPMTSARMVHEDTLIADTFLLRKGAVVQIAGGILHQDATIWGPDVSSFNARRFEHNWTGSKTDKDGNVSNAKGDQVHASAFRGFGGGASLCPGRFIAQMEIISLAAAVVCAFDLEAPQGKTTVEWDPPRDDKRFPFSVVKPLRELNVQLKRREGLEDVHWTLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRP3</accession>
    <name>A0A9P4PRP3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_204512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRP3"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16806" checksum="26A1C51BF09B1CD1" modified="2023-09-13" version="1">MDPDTPTTPAAQPSVFRWILGFLMVGACWGLTTPFMRRAAINYTPPARPSLTDPNNSWLKRKALGIWYAVIGVLSRPAYAVPFLVNVTGSIWFFILIGQAELSLTVPITNSLAFLFTVLGEWWAEKKIISRDTWIGMAFVLAGIALCVQSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS85</accession>
    <name>A0A9P4PS85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_349573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS85"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="17"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="475" mass="51838" checksum="13EC4901D5AC8C89" modified="2023-09-13" version="1">MALVNAAIDEIGMTPFQWKLFFFNGFGYAVDSLLIVCQSISQPAVDLEFGRPVKQIAGVALASQVGLLAGAAIWGFTADIIGRKLAFNTSLLICAAFVLIAGGMPDYYSFSTMVAIYSAGAGGNYILDATNLLEFLPVKNAWLVTFMSIWWAVGYTITGLFAWAFMSNFSCPSTATGPADCPKSQNWGWRYLHFTSGSLVLALSVARLLFVRMKHTPRWLIAQNRDSDAFTVLQDLATRYKRPLSLRLEDLEAQGRVLHTEMSKWSSLRLRKHVGGLFETKVLAWSTIVIIANWFVIGMVSPLYSTFLPYYLASRGADVYGTPSNYTTWRNYAINQIAGLGGPIIAGVLVELKFFGRRGTLAIGALLTMVLQFGYTQIRTPAQNVGVSAAITAVSNIYYGTIYAYTPEILPSAHRATGYGLCVVLNRVGGISGVLIGSYTNVQTTAPLFICASLFGLLVVLSLLLPFETRGKRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSW1</accession>
    <name>A0A9P4PSW1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_349461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSW1"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="39"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="244" mass="27848" checksum="C8B05BF7D9CFE4B9" modified="2023-09-13" version="1">MTSANKVELPEGFLAGPAPNLTKHVIDFKKEGIPVYEGRWAVILDGVLSQDECEMLTKAAEATTAGEWERAMVNVGNGQQRLYEDTRKCGRIIWDDRDMVAKIWARVQDSVLDVHRLQNWADVTGIGPAKRKETWKVTRLNNRMRFLKYVGGEYFKVHNDGCYETPDGAERSYFTLHLYLSDAADQLKGGATTFYDYSLKQKIEVVPKSGRVLMFQHRNLLHSGDDVKSGIKYTMRTDVMYTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUG8</accession>
    <name>A0A9P4PUG8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_426856</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUG8"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="12"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2450495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="355" mass="38231" checksum="3DCF36EEF4B731A0" modified="2023-09-13" version="1">MENPSIVLYRAGDAKLQDTPVPEIVDPHDVLVRIAFVGVCGSDVHFYRHGGISRMVDPAVGITMGHEASGVISAVGASVTRVSIGDRVAIEPGQPCRYCRPCKSGTYHLCKNMRFAADPGPPVTQGTLSKYYRIAEDFVYKVPESMSLEETVLVEPTSVAVHAVKLGDVRPGETVVVMGSGTIGLLVASVAKQFGAHRVVLVDILARKLEFARGFLECETFVSDKEHTAEQNAAALLEAIGLDEVDTVIECSGAPSSIETGIYVLRGGGKYVQTGMGRPKMEFPMTVMSEKELLVRGCFRYSSGDYELAVSMISKGLIDVKPLISSTSEFEDATVAWEKTARGEGIKNLIRGVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUU1</accession>
    <name>A0A9P4PUU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carboxypeptidase s</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_427446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUU1"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="286"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="574" mass="63108" checksum="1657B6F7069D5B7B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVK0</accession>
    <name>A0A9P4PVK0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_427760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVK0"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.10">
        <property type="entry name" value="Arylamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="98" mass="11333" checksum="A39EBF65C1941ED3" modified="2023-09-13" version="1">MSAPQRPVYTPAQIANYFDRLKLPEEQPKYHVSRLDPEHALEYLALLQKLHLAEIPFEKPVSALFATPPDIYPPRTVVRQHHCRLSSWRRSCLAKMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVL3</accession>
    <name>A0A9P4PVL3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_196200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVL3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040274436" evidence="1">
        <location>
            <begin position="16"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="129" mass="14482" checksum="272F907E820EC19F" modified="2023-09-13" version="1">MCVLRNFLLTVKASATSLVWFRGWSQYCQIAGKRHNLTILPMHRDVGMVFPKGSSTLIEGSSNVVPCWKKWMQYSNGLTNSFEYNLIAREQSSPRSLAIVSCGSADDASPSIWLIHEDLCSAFWCVNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWU3</accession>
    <name>A0A9P4PWU3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_426361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWU3"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2451936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="214" mass="21793" checksum="EF378D7F9860F65A" modified="2023-09-13" version="1">MSRPVAKKAAAKGEYIETDSGNKVSRRSAITGTANITLGGRTVIMADVVLRGDLHSTRPTASSSGKEGTPTSISIGKCTVVSTGTVLKPPCRMSRGAPNFYPMKIGDNVFIGPNCVISAIAISSHVHIGANVTIHPFAVIKENVKILPNTVVPSAMVIAPGSVVGGRPARIVGEVGEGWGVSGGGAGGGLGVGGGGEEKWVEGGDLRELVRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWU6</accession>
    <name>A0A9P4PWU6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="14">SDH</shortName>
            <ecNumber evidence="5 14">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P171DRAFT_349874</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="5 14"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWU6"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000627">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="186"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="329"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="216"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2450374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="387" mass="42411" checksum="E61402DEA28CBCEF" modified="2023-09-13" version="1">MSFPTLHARAEGKPFEHRSCLTPTTAKKLLDAGYPVLVERSPTDPNYSRIFKDAEFEKAGATLVDTNSWETAPDDRIVIGLKELPEADSPLKHTFVHFAHCYKQQGGWEQVLARFPRGGGTLYDLEFLQDSTGRRVAAFGYHAGFVGAALAIKTWSWQLTHPNGEPLPGIETFTDGRGYYNNETELIAQLKEDVAAGEKVAGRKPTSLVLGALGRCGSGAVDLLEKVGCPEIKKWDLPETKDREGPYPEIIESDLFVNCIYLSKPIPPFVNLESLKSPNRKLSVVCDVSCDTTNPHNPIPIYNINTTFDKPTVEVSVEGNGPRLSVISIDHLPSALPRESSEAFSDALLPSLLALKDRTTAPVWQGAEKLFNEKSETLPGGVPAKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX31</accession>
    <name>A0A9P4PX31_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_403690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX31"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="52"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="494" mass="55609" checksum="D8446B2B9FE5EE10" modified="2023-09-13" version="1">MMDRILELVKDVPEVSMEKIYWMIDHACRVDKLSLKVVSILLGVLAILASIARLFFRYRSAQTLNLEDYFILVATTCLATEMGLLLSFTDTIYRIDGATLNVSVLKYLTSDPKLSKELFNSRPSILIAYLTVGWLAIFAVKCSFLSLFHKMCRNVSRKLTAYFWVTVAATGTSCIVVILESFILCPRFGADATQCFLENQYTFSISSGVVVQSLDIVTDLMIISIPLTLLKMSQLKLQDKVRIATVLCLSSICVILSISRLAAGMHRNVFGKWQFEMAWLSFMLHCEASVAVMAGSIPALRAFYTYRRSRRIETAQSEKPNEKLPENLKGKALRVLGSMRHKEQPVLPRYERVQPRASIARWRQSIVGIIPRRPMTYKGGNMNVVGPDGQRYSAAESVMIHPTLAYHNIRKQELQRDGIRMKRETIVWSDSVRSKYASVDMSEATSHTGTIISSAGSDPDMKGSELAFPARTMAGKFDYFIDAQFGHIAAEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYE4</accession>
    <name>A0A9P4PYE4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF895 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_468116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYE4"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2451588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="411" mass="45869" checksum="1816217979DC1183" modified="2023-09-13" version="1">MNGLGVGGSQSPDLVNAANALLYAFMTVTCFLGPWLTNLIGFKYTLAIGSLGYPLYAAGLYVNNRFGDTWFVYVGAVACGITAGFFWSVEGAIATGYPESNKRGRYIATWFTFRNFGNIIGGAISLGLNHKVNHKGKVGYQTYWAFIAIQCLGFFFGLLLSNPEKVVRDDGTRIQAPRGIPWRTEATQMWRLLRSKPILLLTPLFWYFGWIQAYPGTYLATYFTVRSRALGSFMSAVVGTFATWLGGSLVDIPWHKSRQFRAVATFAFIAACNSATWIWAVYIQNEYRHTRPVLDWADQKSFGRGFGVYMFERLSLGMVENYIYWCIGNLSDSPGDQIRYSSLLRGIETAGVAVGFGVQAVPTVLIATASINCGLWFFSLPFSYYATRQVVDKFNKLDAEKKQQSPNVQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZU5</accession>
    <name>A0A9P4PZU5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_479224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZU5"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="404" mass="45179" checksum="62325A024E4C427F" modified="2023-09-13" version="1">MDALDQFSPSDIQMEELAFDEVEHPAPSHPKTGNPGSPSIRWVDMSWEGTYNTEATRQDLETMGITWNAEVQDIEKTIRPANPVPGVPPFYLEVLEAGSGVFGTVVLCLPRPHAIAARYRHAQGKPQDVAELKSKLVAVKVMKSIHVKKSQDELRVNEILLRNIRSATATTVPRFATLRGQCEVVAVPKHQTTDHVQPWLALDSIVPSLTVDDLLEKHVYMLEGIAEILILHIFCGVMDAIRFLHSCSPPITHQDIHNGNVMLELTDGLPRVVLNDFDTSDIVSKDYERFDFDFECLCWMMRDFYTDVRDAGVLNDHSNFIPSKRWIEFNNTVLISAAQASSELMKKLAEPLARSILENLPAGGKSQVAECLCRASGPQEVKLLTHFKRMDLLPSTDLGRMSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4Q083</accession>
    <name>A0A9P4Q083_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_426514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4Q083"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2452126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="99" mass="10686" checksum="E8DC5EB439B7F28D" modified="2023-09-13" version="1">MAEQPAEASSSSTPPAPSPPSQACAHCAATPDSLKQCLKCHSVSYCNRECQKAHFKTHKKECAGLAQAYVKTHEPRMASRAPPRETGKGKGIGKWEYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U3Z1</accession>
    <name>A0A9P4U3Z1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_181894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U3Z1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="108" mass="11840" checksum="9872A2DD20415590" modified="2023-09-13" version="1">MSKGECATSRLRKRSRRASRATWTCGRRGRYRGEQLGRARAEERWGRLLSRTTTDFSGGGGALRWPCSPGAVQTGSVVEAGEWRRRSTHGSSRAGQGRAPSSNGQRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U464</accession>
    <name>A0A9P4U464_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_179423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U464"/>
    <dbReference type="OrthoDB" id="5426775at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF1">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="177"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="382" mass="42377" checksum="AB1570CB81E4F7A0" modified="2023-09-13" version="1">MSPPTRKRKTVDSRPHPPKHHRLGETLTPALADNSAPAWPLTAENLSRVEDPSRLAELDLDYRSNISESMASQPGEYDKLAIAGVLVDNQEPMSPPVRQFINDLFGRARDHPSPRAAYVVANAHAARQGGKELAKELLAKGIGLECFRDGGYALSTRHPNIRLDDSFLPNSPKARQDMRLKPAQPDVANGYLTRREAAGATVPFNRDEEAQIMLEMVRNPRTGQLCPLNVTPRMFFPYYTIQWKSNDAMYKATAQGACDGAVINEHLRSLYSAAQGPNNPNESDVVLTMHFSATFEGNLVILWVHFYNPEKSAYHMERVGQFVVDEQEPMTRYRRFLRNLEDYAMGPRLDAIKRALSDISAGSAPGAEQGAAGDDQAAAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U535</accession>
    <name>A0A9P4U535_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_449850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U535"/>
    <dbReference type="OrthoDB" id="10504612at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040486707" evidence="1">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="363" mass="40233" checksum="1B13F1AB4F7EDB20" modified="2023-09-13" version="1">MSLFLGIYLLLLLLAISLVGSESKSTTILHGPLDDIEAVYRSAVSAWRKDVLFQDHHANSNALTCLASRTPNPAFEFLHASAYTNEELTRTLEALGVNSQKVLEALAAADFKFTTLHRRNYAAFAKAEAQLIQTYMDAVGKAKHRHDKCKHLPSSGRKLGFRILHQLFSHIHPLFHQSLSSLCNSTTSHAPQAQSPYTEHLPKADAIVKELIDTLVANVRSESLALELHLHELTSAYRAVHRELWTLDFATDFYWKRVHLGSLVCLWYTGSTTCTSLSLEARSKSREWEGMQAVLQGLQDARAQVLGDLVVVSRLDASVGYAGEYLAELKEWERGGGPGRRLARLAAALGMVVTMECVDELPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5G6</accession>
    <name>A0A9P4U5G6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_506047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5G6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="179" mass="20666" checksum="52DA0A5A337CE61A" modified="2023-09-13" version="1">MVWPWNIIASEVEFGFWTVEDRLDKLHSATETNLRAIRTLRHILEEHIHYSRNSFEKIKLLVDHAPFLILGVLLLLRTLAVWLFPTLHHLAKHWTTPRPEPQQQVPDPRSYNYLPRSPRPKATYTVEPVLLVPVNFTKGLYDNCKVTIPAKINGKELIAEVDVSRTSKIHSSLLPPRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5S8</accession>
    <name>A0A9P4U5S8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_424063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5S8"/>
    <dbReference type="OrthoDB" id="5229512at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="423" mass="47455" checksum="C5182A9C1C70B75A" modified="2023-09-13" version="1">MADQQVEPFRLLDLPGEIRDAIYREILCCFNLVEPTSVKFGFYNQGVVPATHSVDTSILRTCRQVHREAYDVMVKTNQFIQISSIDIDLARLLLSSELPIVTMDRGIARQFQGCVMSVDLSDIHTRPAGTGPRFDFLILGRDWSSFCQMLGEGAAFFGGFEKNVKIDLKMNAYPEHIPDYKAPVAHYFTAERQASLLGSFGTVLRNFRNVVIGGTIDEQLAASTMQAVSSRQWTSPEDVIRELGIRKDIAKTAISRQDSLRMYMDAVVLMRRIYGSADFSRLVDEGDVAFISSFAELYFNILLDACQPILETMRTTLELVRVQAWSNVIHEHVSLAQESLGDFDEAGSNYEPTPVVMAQLAYTIAVSSRILGQALPQGQPAQITQWKRQAVDTILSAVRLNPTDATILAERDRILEWRSGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U696</accession>
    <name>A0A9P4U696_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_467210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U696"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF226">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="537" mass="60402" checksum="A0B07498C2B4F1A4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6T5</accession>
    <name>A0A9P4U6T5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_122062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6T5"/>
    <dbReference type="OrthoDB" id="4490227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="2">
        <location>
            <begin position="34"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="287" mass="31056" checksum="F7AEE0DC01E86D85" modified="2023-09-13" version="1">MAHHVPAPIALGTSLTLHFLVFIVACAKMVGALLGVVEVDLIFPRNETYAPTTNLPIIFAFQNSHLAPFLDPIIEIDAYLLYNANGSTQWTPPDATSLDQLRWANFTNNNTYFAYPTYQRRTFNFETEGIWQLTWTLNWATCTKDSLAKTYSKDQLMRNQSQHTTMLTIRKGAQEVDLVSGTKDKSCSGQEGVAVNITNTLQAPLSAHWEGQGDMCASTASSVPKSDLCRVSIDPTAAASISCAVSLATSSATSSSLACPEEKKGAAERLTIGGLAAMVGALSYLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6W5</accession>
    <name>A0A9P4U6W5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_458034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6W5"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="325" mass="36413" checksum="889E4B43F726767F" modified="2023-09-13" version="1">MSTSASDSPKSFHYEFETLKGYFAQSEDSTDDSKFDFIKEEFGLLERKYDTDTDAGKDQGQGQWRRFEKFVRDLNEKSAVGESVKVLFLGRHGQGFHNVAESKYGTKAWDCYWSMLDGVGDVTWSDALLTEVGQGQAKDVHGLWQKLLPKGIPPPETYYVSPLTRTIETADLSFKGLDLPHDKQYRPYIKELVREALGVHTCDRRSTASHIVKTFPHVTLEPNFSEPDVLWEADYREPRSARQYRLSQLLDDIFDNDDGVCLSLTSHSGAIGSILAAIGHRTFALQTGGVIPVLVKAKRVEGPRSKPPKEPSKAPPMCKEPPVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9M3</accession>
    <name>A0A9P4U9M3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">OPA3-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_365161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9M3"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2442146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34622" checksum="25B8AB1A45F6D567" modified="2023-09-13" version="1">MSLTLKIASLAVRTLAKPIATQIKRNAHEHERFRGICVRFAQRLHRFDMRMRLGLLQDPAVIDRQVAKEIKAAEAARKKLDQTPTVKTEAETAAEEAMTKEEKESARKKIEAEAKRQIEAATRRRPLSETKAIEMGANFVAEAFIFAVGISVIVFEQWRQRRKARNQRDDIREDVEELKEEFKSVREELAELKSYHSEPSSISLLPKFLTGKSEAQKPTEKLLSKTEEDDIKRSLRGLRRELKAVDQELETIKERHQSTSLLSRVLLWREKEVDPKSHTTEAQNTTASLSAPSTAPSPTEQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9N4</accession>
    <name>A0A9P4U9N4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_392690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="107"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="628"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1310"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1313"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1343"/>
            <end position="1356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2441413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1356" mass="151535" checksum="4C0D3FD49762A0A4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9Z9</accession>
    <name>A0A9P4U9Z9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_69202</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9Z9"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="18">
        <location>
            <begin position="76"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2442536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="422" mass="45511" checksum="33434360E34123B1" modified="2023-09-13" version="1">MGDHSKYYITGAFILGAVVAVGLQSLQQHGREAAGHQQQQHQIALRRLSKINDLDTLKKNLSDIEIASGNIKEGIEGCIGDTPLIKIKSLSEATGCEILAKAEFLNGAGNSPKDRVALSIIQMAEEKGFLVPHSGDTIYEGTVGSTGISLAAICRARGYKAHICMPNDMATEKSDLLLKLGAEVERVKPAPIVDQNQFVNLARTRAKEHTESKEKPGRGLFADQFENEANWRAHFTSTGPEIYEQTGGVVDAFVSGAGTGGTISGVALFLKSKLPDFKVVLADPQGSGLFNKVKYGVMFDPKEREGTRRRHQVDTIVEGIGINRVTHNFEVGRELIDDAIRVTDEQATGMARWLVEHDGIFVGSSSAVNCVAATKLAKQLGPGHRIVTLLCDSGARHLSKFWANKDVGGAENDVSLDRILAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB19</accession>
    <name>A0A9P4UB19_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_43821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB19"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="578"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="598"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="635"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="671"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="708"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="744"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="780"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="816"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="852"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1021" mass="111711" checksum="5DCF1F104F6A44C3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB34</accession>
    <name>A0A9P4UB34_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P171DRAFT_455635</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB34"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="20">
        <location>
            <begin position="101"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
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    <sequence length="450" mass="48771" checksum="782DED93B6DF1DB2" modified="2023-09-13" version="1">MIEQRQIAVAKHNTAESCWVVLYGKVYDVTDFIAEHPGGSKVILQLAGTDATEEYDPIHPPGILEENLKPEQHLGTINPDTLPAVEKSPVETGEAEQAGPVDLDSILNIDEIEEVATKNISNKAWAYYYSAGDDLASKKLNNTVYRQILLRPRIFVDCTKCDTSTSFIGHKVKLPIYVSPAAMARLAHPDGEWGIAQACEQYGAMQVISQNASMTPEQIVADAKDGQVFGWQLYIQTEIAKSEAMLARMKKLPAIKFICLTLDAPVPGKREHDERSKNVGANLPIKAAVQEDASVSKTSSDAKTPSPPKNMGVGQSLFWGTAADLTWKTTLPWLAQHTDLPIVLKGIQTHEDAYLASLHAPQVKAIILSNHGGRALDTAPPAVHTLLEIRKYCPEVFDRIEVWVDGGIKRGTDVVKALCLGARGVGVGRAALFGLGAGGKEGVARVLESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBA2</accession>
    <name>A0A9P4UBA2_9PLEO</name>
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        <recommendedName>
            <fullName evidence="2">UDENN FLCN/SMCR8-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_24757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of TORC1 signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FLCN/SMCR8_DENN"/>
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        <property type="entry name" value="Folliculin"/>
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        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
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        <property type="entry name" value="FOLLICULIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DENN_FLCN_SMCR8"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="194"/>
            <end position="436"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="436" mass="46946" checksum="2E83AD67563CBD6F" modified="2023-09-13" version="1">MDFTISLAHFCEVHGPTSIICTQASPSPCGSCNPCVTPPSEEPHPQLSYDGLYEQPPSALKLGSRIPHLTSPLETPPTSPRSPSHNPYFPSLPASNSSFGGRRPSSTYSTDNEVCDNCQIVVPKKVSARIPNGAPGSPSKDGRGRNGSPVLRTSHNFPVRGSSTCDDMSSSTSSDTSDTEQSKSFDSNRSHVFPDSPMYSRGMHTHTLSYVSTSQPQSPATYSLLRRTCIRTLSTETLPMGKAAGPMFFGDSHAGYTIAYVFRLRDPRARGAMRTYALIAMAGRDGMRATKAMVKITEVFESIANRIVALADRVLEKDSAASQPLHSRQASSTSYSPPFGTSASSVPLFQTSPVKDRPISSVASSPATTRNITPVSSFLSAKKVDPDGYPRISSEVMKAKNLVEIVGMEDFFVWLHGIFCGLLHSLINQFGQLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBG7</accession>
    <name>A0A9P4UBG7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_494296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0032012">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="PH_9"/>
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        <property type="entry name" value="Sec7_C_sf"/>
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    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
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    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR10663">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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        <location>
            <begin position="1436"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1577"/>
            <end position="1588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1602" mass="175003" checksum="497981DE6F4E80AF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBH0</accession>
    <name>A0A9P4UBH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_268261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBH0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="72" mass="8351" checksum="60B9CDF8B9537762" modified="2023-09-13" version="1">MQRLVRMVTLKTMPAIRLAVRYVVLLVRLACSRRSGWTIKDEVGAETGWGLGPSHTSPTRFERHGNYRRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBN7</accession>
    <name>A0A9P4UBN7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_521748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBN7"/>
    <dbReference type="OrthoDB" id="5304354at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53311" checksum="D760C3887DCB52F8" modified="2023-09-13" version="1">MALRSLPPELTITIAELLGPFSSFDLALTCKAHWNLCNTIVQKHKRLFAENRVIDARDASYPYQNHILWDKLKEILNDPNVGEYVREMNLPSSRAIYLDGDAAHDFQLTAQSAKLLQEDVDRFAGAGEQVQDLYRSVDLGHVVPGPSEWDEYVLNGSSEPIIVMLVQHMPYLKAFRFTDLEMSAVFCRCLCAAAVAYNDPVLAPQLPFQHLTTVAVAHWDTEGSCDVEWCQYFCAIPSVRNFVANAMGGDVEPGLVLPEQLPKSNATELVFHYSRFETAALEAIVSNTPFLERFSYDLAGATVDESVTPMPKQDLKALVQHVGHSLQHLLFETPEYGDDFEEDIPEVSLRGFQKLKTLRIDWHLLWPTDTILFDNEEKSDGGFYEEDHETAGADNGFDVRSVLPESLEKLCLTGSFTEEEKELVSRIRDTPSEYTPLLKKIYIRDSSVLLLQDEDVPGIYVNPLMKHLEGHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBZ3</accession>
    <name>A0A9P4UBZ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_432836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBZ3"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2443617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="612" mass="66017" checksum="DFE567A02047DCDF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCH8</accession>
    <name>A0A9P4UCH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_383539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCH8"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="510" mass="57883" checksum="F6FBA9398AFDAF60" modified="2023-09-13" version="1">MEVQSFQSLAHSAQTVAIAALIFVACYYYPKLSFRAQVAKLPAFTENGEKQRQEFLKHGKNMYLQGYERFKNQVFRMTGSDGRETVVVSPRFLPELRKLPDTVVSFPKAIEDLMEVKYTGLIADEPLGVHAVRADLTPALARLNPVVYSEVLQALEEVMPKCEDWTAVNIYSKLVSMVATITGRILVGADLCRDKEYQRLSIEYTMQLITAQLEIKKIRPLFKLWSAPRLPSVQRLCKARKDLAEFLEPIIQARRDAEKNDPNWQKPDDMVTWLMSRQGEFGVKSTHHLAQLVLGLIFASIHTTTLTATNVLYTLAVSTEYVEPLREEIREVVAENGGTISTRALQQMMKLDSYMKESMRFYPPGFTSFQRKVIRGFTLSNGQYIPAGVTIEVASHAVYQDPANYSNPEPADIFDGYRFYKLRQGGTATDHARNQFVTTNEQNLMFGYGKHACPGRFFAANEIKMILANLILNYDFKNEDGSMERYAQLDVGRQSSPDARKNLLFKAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCN5</accession>
    <name>A0A9P4UCN5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_432410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCN5"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="147"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="359" mass="39500" checksum="AA339BC0B2C8A424" modified="2023-09-13" version="1">MATDPRKRKAGPDQRDGGNRKKSKGRQKWTVPGGENRGIQAGDTGIWVTCAMNKEAPSVSDLRNLFEKYASQLYGDTQTAEAAEGEDSGASDGDIENEIRKEVEGIRKPKVAPLFKNVKLPGQCLIFFKTRSPVEPVSFLHKICQDTADGVEPQRCRFVKRLTPLSAIGKVAGSGLKDIATEVLAPHFHGPEKTGKKFAIRVNIRNNKQISRDEIIQQVASLVGKGHKVDLSGYDLLILVEVYQSVVGMSVVGSDYDKLKKYNIAELRDNTISNDQKELAADNTISNDQKEVTDDNTKPKDQEEVAEDNTNPQDQEDVAEDNATSNNQKEAEDNATSNDQKEAADDNAISEDQKQVTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDQ4</accession>
    <name>A0A9P4UDQ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_517697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDQ4"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="274" mass="29916" checksum="C4D349F8A1F813BE" modified="2023-09-13" version="1">MPSYVITGASRGIGWGFVKHLSEDPSNKVIGLVRNAPPTIERVKTELSDRKNIHILQADLIDNAAIKKAAADTATITSGSLDYLIGNAAYTDGFDQFDSLGGLLAKVSPEELTRQFHNFMDTNVLAQVFLYDAFLPLLLKGTAKKVMSISSGMGDLQFNRDYDLDHAIFYSSSKAALNMVNIKFGAQYKKDGVLFISMCPGVVDTGYADKILPEQVAKLQEILDKFHAYSPTSTGPSQPAESVKKMLSVLDTLSIENGDQGKYVSHTGTDRWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDR0</accession>
    <name>A0A9P4UDR0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_411247</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 16"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057030">
        <property type="entry name" value="TPR_Rkr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23280">
        <property type="entry name" value="TPR_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1565"/>
            <end position="1611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2445417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1617" mass="178500" checksum="523A359E1118684D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDS9</accession>
    <name>A0A9P4UDS9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_265942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDS9"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="194"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2445477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="435" mass="49303" checksum="12BD41F37AD63ED5" modified="2023-09-13" version="1">MPPKRNATDDLSDLRQRSRFDYLEKREALKLAELQKDVEEDEREREKYGSKLSKRELAEMDKRKMTLRLTLERNQIDDTNSGFFMLDSTLTDKSEVLTKRNKKENYKSEVQLWEEEQTSKAKAAQGQQRVRESEDEYEFVFDPSTSINFVGDGVEFDADKQRLQAQLDEAESRAKSIADVRTSLPIHAYKKELLQAVDDNAVIIVTAETGSGKSSQIPQFLREYFISRGEPEKSVYCTQPRRVAAMSLAQRVAEEAGCRLGNEVGYTIRFEDKTSEKTRIKYLTDGTLLRMFLTQPDLPEVGCIILDEAHERTLSTDLLMGLLCDVIKYRTDLKIIVSSATLDAQAFSNYFSQAPVLYIPGRTYPVTTYYASQPEASYLSAAITTVWQIHASADAGDILVFLTGQDEIEVALARLVAPQIMMASELTRTVSKKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDZ5</accession>
    <name>A0A9P4UDZ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_520116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDZ5"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000013">
        <property type="entry name" value="TRAPP complex subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="172" mass="19278" checksum="D2C6F83B9C09C68F" modified="2023-09-13" version="1">MVLYSFYIFDRHTECIYSRRWTPTPTPTRPSSSSSKAARPPSTASTVSSSPTAAAAARAKAVDDEKLIFGLVFSLRNMVHKLGGTDDTFLSCRTAEYKLHYYETPTRMKFVMLTDTKLNNLRPYLHQIWANLYVEYVVKNPLAPVEHPGGIGVANELFERALELFVSTALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE59</accession>
    <name>A0A9P4UE59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_409457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE59"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="77"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="256" mass="27895" checksum="7C3A040578FD306D" modified="2023-09-13" version="1">MLQSSITAWLKKPATVMKADQPTPVAAPPPMPLAQQAQPAMSPSEPSSAPTQERAIELAPSPPTAPLFSTPPLPENVELAPLAEELIPSFKRILSLTLPVSYPAVFFTESMEEPFHSITLMALWHPAPVNDGARNSSTEKPRLVGAIRCRILPSANLYISTISLLAPYRSHGIATHLLQKVAAKAVGMHGVRCVTAHVWEANEDGLEWYKKRGFDIIGKEDAYYHKLKPQGAVLVRKWIGVADLLAHPDAVSVLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE80</accession>
    <name>A0A9P4UE80_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_483550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE80"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="63" mass="7582" checksum="6667B2B22DCB053A" modified="2023-09-13" version="1">MPSHKSFRTKQKLAKAQKQNRPIPQWIRLRTDNTIRYGSLDALHARDAYNAKRRHWRKTRIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEE0</accession>
    <name>A0A9P4UEE0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_481842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEE0"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04433">
        <property type="entry name" value="AFD_class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="615"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1250" mass="135974" checksum="EF1FFBFDB63504CA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEE2</accession>
    <name>A0A9P4UEE2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_250171</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEE2"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="153"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2447351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="303" mass="34070" checksum="35ACC9BC82EBE2AF" modified="2023-09-13" version="1">MSEITLVVRPRGRPIKNLPETITVQADGVASQIHQKIADASRFSVHRLRVTKGSDGTPIANTKEATVHDTGLRNKSAIDVKDLGPQISWRTVFVIEYLGPLLIHPLVYYGRPLIYGSSEAPSELQKITLIMCVLHFLKREYETLLVHRFSAATMPARNIFKNSAHYWLLSGLNLAYWAYAPWAPTAGKSNPLITYSGIALFAVGEVLNFYTHIVLKNLRRPGTTERGIPRGIGFNLVTCPNYFFEIMAWIGVALVSWSLGTVVFLVVAATQMGAWGKKKERRYRKEFGDKYKKKRFAIFPGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEM1</accession>
    <name>A0A9P4UEM1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 34 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_430167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEM1"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000149">
        <property type="entry name" value="Alpha-1,6-mannosyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF10">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2447260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="322" mass="36078" checksum="604DBBFFD9544B56" modified="2023-09-13" version="1">MHFAMPPRKTSRPPPYAVRNQSSLPIPPALKNLLRGGKLRTIVVGILGFLTLIWLLRRTGADAGANIPKVAVGSGPPVVIVTTIDPRADVAWAAKIKKNREDYAKKHGYLTFFPENTQYPLNKSPHTWAKVPALRHAMTLFPGSTFFWYLDSSALIMNPSIDLQSHILKPSRLEELMITNEPVVPPDSVIKTFGNLKGDRIDVIVTQDKEGLVPTSIIVRNGDWAKYFLDAWFDPIYRSYNFQKAESHALEHIIQWHGTILAKLALIPQNLFNSYATGPFNPKFGKYTEGDLVANFPGCARDKPDCAAEQQPYFDILDKDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEM7</accession>
    <name>A0A9P4UEM7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_520086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEM7"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053212">
        <property type="entry name" value="DHP_3-monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054707">
        <property type="entry name" value="DhpH_subs-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469">
        <property type="entry name" value="MONOOXYGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469:SF2">
        <property type="entry name" value="OS06G0597600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22607">
        <property type="entry name" value="FAD_binding-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2,6-dihydroxypyridine 3-monooxygenase substrate binding" evidence="1">
        <location>
            <begin position="210"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="401" mass="44669" checksum="6833A02118969DB0" modified="2023-09-13" version="1">MGSDAVIIGGSTAGLLNGVMLKHHGYNVTILEQFSGTRDGYDAGITIGPDVKSFLAKHDRVQRPFALTCTPPLKFNIQGKPRLEHKQTMVMTCWALFSKILRVNYDGTTSTAVPVAPEPSVTDGTVEYRSGARVTGVKDVGDRVEVHYEDTNSHVSTTISAGLVVVADGSTSSIRKLLAPDIERRYAGYICWRGTISESSIKNKEFNENYSTPTDDGDLDQGKRLYNWVWYMNLPENSSDIERLFTDVNGKQHQGTLPRGLVRPENWEKQKSLALSVLPPGLAEVVSKTTRPFLTRIYDVTSSKIIFFNSKLFVVGDAAMSIRPNVGMSTQLAAYDCNMLERVIEGKITPSQWEKVFLRYKYAQRRFGLTVAAYGLRSKFTAVWEGLKWLLLLLLQKVGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFF0</accession>
    <name>A0A9P4UFF0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_236849</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFF0"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="372"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2448040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="476" mass="52222" checksum="C98BB68B73FEAC9F" modified="2023-09-13" version="1">MADTLPSTAADNAVRASAKRTREIFAADTLQYPSTGVDSTRVSTRIHQEYHHVQELPAALAAKMATAATTAAEKRRKIKNANAEEQASDPKMRKMIAASSEKAEKAKEAQSMALTVRTGKGAAPNAQGPTPMRDTPSSALVRKDTVRAVKPEWHAPWKPFRVISGHMGWVRSLAVEPDNQWFASGAADRTIKIWDLATGTLKLTLTGHISAVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYSLSLHPTLDVLVTGGRDGVARVWDMRTRTNVHVMGGHKGTIADLQCQEADPQVITGSMDSTIRLWDLAANKTMAVLTHHKKAVRALTIHPSEFTFASGSAQSIKQFKCPEGAFMQNFNGHNSIINTLSVNEDNVMFSGGDDGTVSFWDWKTGHRFQQTDSIAQPGSLDAEAGIMCSTFDKTGLRLITGESDKSIKLWKQDDSATEDSHPLEWKPTLGRQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFG3</accession>
    <name>A0A9P4UFG3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_351254</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFG3"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12296">
        <property type="entry name" value="RRM1_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12299">
        <property type="entry name" value="RRM4_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000632">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="826"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="900"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="990"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="1105"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="747"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1189"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="767"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1078"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1205"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1237"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2449974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1258" mass="142019" checksum="ABD8389105927E10" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFT5</accession>
    <name>A0A9P4UFT5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_440770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFT5"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="199" mass="21459" checksum="1746562D4DD1F2E5" modified="2023-09-13" version="1">MRVPTTSTTTEPYGSLVITQRLPQPTLSRTNQPRSAPPSSSIAATTPSASGTPPHTQPPAQTLYSPITGKPGKPTKPSRNPSPRVPKRPTRSSTRKGLFYYDFSFVDCAKDIAYRQGNAERCPGWDAGLQIQGTSGCKEMICGKGERCIHNGQGAYYIDESVQKWGLGEPVGTCPNYKEGIEIGFVLCSSAPPLTKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFU2</accession>
    <name>A0A9P4UFU2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline phytoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_429465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFU2"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="316" mass="36593" checksum="BD551A641ED060D6" modified="2023-09-13" version="1">MVFDFLKRLPSVEYPPAQEGWWSPVTSTLNWCEEDYYATVYSAELINTLTNIWFMYLSAKGIHNCLADGHGTAFLVSYIGYLLVGTGSFLFHATLKYPMQLVDELSMIYTTCLMCYVTFSFGKTSIYRSVLASSLVGLSLFITLYYHFLQDPVFHQTVYAILTAVVFFRAVYVMETLLRPKFRTEPIGKREEQRNVRILSEMWVLVAWGLGIFLGGFFLWAMDIAHCSALRRWRREIGMPWGFFLELHGWWHLMTGLGGYCYIVWGIWLRHCLNGRQDEFKLHWPRLTTMPVVVRTHNAANGHASDHTNGLAKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG12</accession>
    <name>A0A9P4UG12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_429640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG12"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="261" mass="27211" checksum="00E2046DB614177D" modified="2023-09-13" version="1">MRTPHVLITGGSRGIGLSIASLFARHGHRCTLLSRSEAPLRTAVVSLNEQHPLPSASAQHAYIAGDIASPAFWSASGIGAQLPAKEEGSRLDVLVNCAGITQGSLFVATEADRIQNIVDTNLTGMMVGTRFLLRGRYFGGAPRKDVREGKGNRCIINVASLLATHGGHGAVAYAASKAGVLGFTRALAAELGRQGVRVNAVVPGYVETDMTGGLDHAALSQRIPLGRLGKPEEIASAALFLAQNEYAHNCVINIDGGLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGC0</accession>
    <name>A0A9P4UGC0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_205952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGC0"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="214"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="409" mass="44053" checksum="A9F3713665E29C37" modified="2023-09-13" version="1">MEIILSINAGSSSVKISVYKAEPSSPTPHQLAEATIEGLTAPPAKLKYSRGDENIKGKELEDIASQEDAFKYILSHLQNDADLPELSKTDDIHFTCHRVVHGGDYPHAQIIDKETFHHIAELSDLAPLHNAPALSIVRAVSEILPNAKNVAYFDSSFHATIPRHISTYPVDQEVAERNKLRKYGFHGISYQFITDAVASHLKKDPTTLNIIALHLGSGASACCIKNGVSHDTSMGLTPLAGLPGATRSGSIDPSLIFHFTHSAGSLSHAAAGHMDITQAEQILNKKAGWKALTGTTDFADISSSGEEMKMLAFDIFVDRIMNYVAPYFAKLVGEVDALVFAGGIGERGARLRKEVVRGVECLGFGLDAERNNQPGDGVVADISAGDARFKTLICKTDEQLQMARGVAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGE0</accession>
    <name>A0A9P4UGE0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_480042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGE0"/>
    <dbReference type="OrthoDB" id="3798920at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="171" mass="19511" checksum="BA4C21B5C30212F6" modified="2023-09-13" version="1">MSPLNSTLHLLSAHAADAGTTKHTGIQVQWVPLLVLIVIVILIVIIVVTPKGWMINVYNRIRSAKKQGSATPQPPRRLFFLFSSHSRADDEKCRLKEASHQRPEHDASFIDVHLREIRAFKKPDLQSVQRHESNVLEEVGLPLPVLHRDKRHERVQQCVMSWLKDDKGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGL3</accession>
    <name>A0A9P4UGL3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_217369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGL3"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="30949" checksum="F855F6FD4ED1B333" modified="2023-09-13" version="1">MSQLARSTQGAAPITPRTPSSAPATPSAQREHESTPGRWKHPQFDEIARRQYATTFDERNVRMIVTNGSLLVGTVVAPAVISQISLLRILSKPVLGLLHQLPYHGDEWTLFLFRLIFLVNLVRAFMPLARRYFPDDIADIALTPSQRHAMGLKPGVPVPQSPASGYASPNYVTPPRYQKSTPRSSFGAQGSQSPLSGSPRASLGMSTSNSPFSPSTGSPLFQKAVNGGSVAKRMSFGGSTPGSSFFGESSSSATPSTPTPSTGKASVGLNNKWLYEKRRDSPRSSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH27</accession>
    <name>A0A9P4UH27_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_407109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH27"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="13"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="373" mass="41193" checksum="58F7DBF7A5559B18" modified="2023-09-13" version="1">MVAAEDSGIGSDVQLSLAKSIVIASFTAIAWYNVLELTVLIHSFFKRRAGFYYYSLLAATYGIFFHCLGQFLKFFHINDDGSQARDIGYTVIAYTGWIAMVTGQSIVLYSRLHLVVQAPWVKWILVYIIVDGVILHGITGVLTFLSNCAPDPTPYIPIYSVVEKIQITMFFVQECILSGIYIWKTSVMLRTEGPMFNAKENARGSRGRKVILHTLLMSILIIVLDATTLGLEFAGLYDVQTSLKGAVYSVKLKIEFTILNQLMNLIKGALRDTNTSISHTQTAKSRPRRSIRAADLGHSAGAYSRMDEEGYGPGGIKLQPLKAGEINKTTTTEVRIDELEIEKGEVYSSAGKKGDSSSRGSSEVYIIEGRNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH80</accession>
    <name>A0A9P4UH80_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_478929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH80"/>
    <dbReference type="OrthoDB" id="5383057at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="205" mass="20125" checksum="6C57D960BC66787D" modified="2023-09-13" version="1">MSSSAGTKVTDPTASTNESTGLITSDSLAAESLNASGSFAANNPHAAASQQPSASTTSNTTDTSGASRLPPAPDAEARDAQAAWQETSQLNAAQGLGGKSALNGSAESFSPAGGVPVTGGYAGAVEQARGQGEGRPHGTNVTEDPGLTGKSVFGAVGTKQDPSRVAELEFAKRDALPGGATGAGKDLSSQTGDSKFSGLARDESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHP5</accession>
    <name>A0A9P4UHP5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHP5"/>
    <dbReference type="OrthoDB" id="5424021at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="171" mass="19256" checksum="81C390A6BC5274D2" modified="2023-09-13" version="1">MATPTVWANYVPPRGQCNYKPSIMSAKCPCLRFMLHPLKSTSSFECDGCGHHASFHSMENKEEDEIRKRWEQEARDKALREQREGLDRPRKRPREIEYGRGNVTSSQVRTIEAGIVTPDEETASETGSARVVTKGKGKGGKAAPQVSKRGSRTKGKITEIPEDDEYFIELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHR1</accession>
    <name>A0A9P4UHR1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair protein rad50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_148674</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHR1"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="164"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="277"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="389"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2450906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="86381" checksum="57C94BECF1A4E825" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIJ0</accession>
    <name>A0A9P4UIJ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_478283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIJ0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="56" mass="6196" checksum="58DBCF3444E71904" modified="2023-09-13" version="1">MSPFTEFILNSIYLLCVAYVALSALEILLSESLPLKIAFLLGAAVGSFIIRHLQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P485</accession>
    <name>A0A9P4P485_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_437143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P485"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="612" mass="69586" checksum="B5CF0B9EC733AA18" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4H0</accession>
    <name>A0A9P4P4H0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_437245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4H0"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2438190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="271" mass="29917" checksum="666F730AF10041C4" modified="2023-09-13" version="1">MSRTQALSSFIESAPPGELHDVTKAIKNILGEDSVQSELEPAFQKHNEEQFSLVKLPGSNENVIVSPYNSLGDGRYYDTENQSSFAYDHASLAATASDVRSHVVESNHEDLVKSLLKTLRSHGTEHYPKYHIGVYPTNDDSQIALVTVASKYSPANYWNGRWRSSYLYTPASSTLTGTIAVDVHYYEDGNVRLLTNKAVTSTINGSSAGDVVKAIAQAERAYQENLNKAFGGLAEGAFKSLRRQLPITRQKIEWEKISGYRLGQDIGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P586</accession>
    <name>A0A9P4P586_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_178270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P586"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="223" mass="23416" checksum="4F8966197B9DA4F3" modified="2023-09-13" version="1">MRNVWSLLAGAGSVVAQYNTGSAPAISSSSSAGYVVPSPSSIEYETPSPSPSPSPTSETPPNVSYSSGGYETEAPPPSSIEYETPSPSPSPSPTSETPPNVSYPSGGYETEPSSSGYVIPSTPPGYGTCSAVTIISTTTKTPRPVYVTTTTTKTPRPVTSTVTTTKIPRPVTTTTTKTPRPVTNTVTQTNWSTTTFWDTVTFWRNSTTTSTETTVSHRDSVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P640</accession>
    <name>A0A9P4P640_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_477886</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2438002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P640"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="731" mass="82049" checksum="432577446D9E8476" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6F1</accession>
    <name>A0A9P4P6F1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_370586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6F1"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2439240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="176" mass="20471" checksum="043DCA6C81D70984" modified="2023-09-13" version="1">MPAVLRKKSTVERLDKASSYASSKNRRRNQNRRDGQREREPTPEDEKLKDATTLYVGNLSFYTTEEQIHELFSKCGEIKRLVMGLDRFQKTPCGFCFVEYYTHQDALDCMKYIGGTKLDERIIRTDLDEGFAEGRQYGRGKSGGQVRDEYRDEYDPGRGGYGRAIQEEESYAKEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6S2</accession>
    <name>A0A9P4P6S2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit Ten1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_436097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6S2"/>
    <dbReference type="OrthoDB" id="5275361at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13150" checksum="9643AB19DC3CD3DF" modified="2023-09-13" version="1">MNGPVASTLVLLGELDRCTPGTKVRFLGCVDEYLLKSATLRLKHAYPPAGAPKIASVNIEHVLESIKRHEIEVGSWINVIGYTERRKEKGIHVQAIAVWSAGNVNLDAYQSAVEKRKEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6V9</accession>
    <name>A0A9P4P6V9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_526793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6V9"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2437561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="396" mass="43173" checksum="BC4D6244C7CE9E33" modified="2023-09-13" version="1">MAIIVIVGINGRQGTSVAEAFIDAPGIRIRGLTSSPNCPASERWKKMGVEIRDETFDDEEHIKESFAGADVIFALTSYHRLLEDRRLKLAVEVGLRPSAQFAAMRREVFVGRILLDAAAATPRLQRLVMSTLPVTNSGARYASHTAGATYLAKREHINYMRACLPGLAAKTVLVKPCMRMEDYQATLRMSEDGTLSFGTTAPAHVPLHWINMKEDFGIFVRTIILKLPVASLAVAAYSDRVSGENICALISKISGIPCSYRQYTVDEMEGLGKNLASDLLPDPPGSVLYDGNVFTPASINEAMGRYNVSVQQTSFEDYLKAVLPGHIASLKVRNDKEQGAPGPVAPLAKEEGGLLLLVPSSQPDRDPDAQSAVLSDVFMGFHRDAPDRIIAIYFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7P6</accession>
    <name>A0A9P4P7P6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_477231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7P6"/>
    <dbReference type="OrthoDB" id="4107213at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="321" mass="34877" checksum="8DCFB991D78C5488" modified="2023-09-13" version="1">MSDELSTLLAPLLAPTLRHLLAPIPLTPLSRLPPSRLLTTALPHIHTIELVSPPAFAAAYAPLYTTLFHGPEREHPSLIVSRLRHAAEGKRAGLAPYRVVGLRGEGGKVLGAAQFSVLLLNDGLAVPYLQYIYTSPEHRRQDLSEVLHTLVLAVSLAEATNHINDTAHVAVPFTLFETEPPTHGADDPARQKAKTRTTIHAQSGSRALMLRRLSTPSASPSSSHTYLSAHVQPGLELNDPPLTLIWVVRPNPDPALHTEDLDVGEIGPALMAAVYRSFRDEGFLEANIALAEEMARRRGVGAEFCLMELGRVEEGMYVGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P891</accession>
    <name>A0A9P4P891_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_133109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P891"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2439200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="538" mass="60401" checksum="BCE5CC215D88C657" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9Q3</accession>
    <name>A0A9P4P9Q3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_446915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9Q3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="194" mass="22217" checksum="6B2E7C1BECF27F17" modified="2023-09-13" version="1">MHTRNIELLHGAQVVLGYFIPPHTTTNILPTSLAHPQVIPSYRTMEYTQPQLPSTPTPSTPTFTVSSAHPSNLKSTQDISSSGRGYSDAGLNRKRKNSDEHEESESQYPEQKRNISFTRADSPRPATRRRLEDYTTEAERFRVCLAACVSRLEFAQEASRMQRVREWVCEQRRLREGSSVVRRGDIREFPIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB11</accession>
    <name>A0A9P4PB11_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_318907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB11"/>
    <dbReference type="OrthoDB" id="5386682at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="78" mass="9206" checksum="7A7C6303B804530F" modified="2023-09-13" version="1" fragment="single">HHIEDEGTSCNAASYEWGTSDAHSPIIVNDHLFYIRRNLHEFFQVLRLSDFEDTPIFVDAIYVNQEDTLEHNSQLRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBQ2</accession>
    <name>A0A9P4PBQ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_475460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBQ2"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="353"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="746" mass="84155" checksum="6030A55CA13F71BF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBV9</accession>
    <name>A0A9P4PBV9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_456979</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBV9"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040323239" description="beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="9">
        <location>
            <begin position="64"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="169"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2441077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="709" mass="78509" checksum="F685E4D8084BDDAC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBY0</accession>
    <name>A0A9P4PBY0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Williams Beuren syndrome chromosome region 22 protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_465710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBY0"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="10">
        <location>
            <begin position="51"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="9">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2441165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="280" mass="30136" checksum="23024ACE14D88660" modified="2023-09-13" version="1">MSRPEDILPPDLFYNDSESRKYTTSSRIQRIQSDMTHRALSLLDLHSPSLILDVGCGSGLSGEILSNTADDGTPGGPHVWIGFDISSSMLGVALEKEVEGDLFLADAGQGVPFRPGTFDAAISISAIQWLCNAETSEDSPLGRLSRFFGGLYASLRRGGRAVCQFYPKNDEQKKMVSQAAIKAGFGAGLLEDDEGTKNAKTYLVLTVGGGDLDGDITGVVRGMDGVDVMARPGVARGAKRGQEAKGSKGWILKKKEQMERKGKVVKASSKYTGRKRRVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC37</accession>
    <name>A0A9P4PC37_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_499258</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC37"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2441255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="321" mass="35269" checksum="BDD11BB29C5A6E04" modified="2023-09-13" version="1">MSLVSGPGRGVASLPAETRLVVDKHVRYVQSLDTRKDELEYWLTEHLRLNGLYWGMTALHLLGHPDALPRKGILEFVFSCLHESGGFGAAPGHDAHMLYTCSAVQIIATLDAFDELEAHMQDGRRKIGQWIARLQDPETGTFAGDEWGEMDTRFLFNAFLSLSLMGLLDLVNVDKAVQHINSCANFDGAYGTSPGAESHSGQVYTCVGALTIAGRLDLVNQERLGAWLSERQLKNGGLNGRPEKTEDVCYSWWVMSSLAMINKLHWIDGEKLTAFILGCQDPDLGGLSDRPGDMVDVFHTHFGIAGLSLLKYPGLAEVDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC67</accession>
    <name>A0A9P4PC67_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-lactate dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_94089</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC67"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00300">
        <property type="entry name" value="LDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="150"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2441300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="327" mass="34914" checksum="83485EB2EB157001" modified="2023-09-13" version="1">MAEQRLKTSIAILGSGDVGATLAYTLLQNPICSEVILVDPKRELLEAQVRDLGDATYGGRAATKIRAGTHQEAGQADIVVITAGAKQKPDESRLSLLRRNLQILSSIFTSMSPISPHAILLLVANPVDILTYFARKLSGLPESQVLGTGTSLDSARLRGILAQKAQVSPSSIDAYVLGEHGESQFVAWSNASIGSTPLRLALSQHLTDEFKTDIETHTRGAAGAIIAAKGCTAYGIGNVAASICKYILFDSRTVRPLSFYQTSLGCCLSMPAVIGRKGILRAMPIQLDGDEQKLLEVCAEGLRAVIEGAEKELKADDELRHALEKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD28</accession>
    <name>A0A9P4PD28_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_456913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD28"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="468" mass="52635" checksum="5435F1A672F835A7" modified="2023-09-13" version="1">MTDVEKRDIQMQEYRKASLEELEQVPTVDTVHQDEALKVLAQYAGDQAWSPEEEKKLTRKVDRKLIALLYVTCGLQYYDKAMLPALFGLWTDLQLEVGDRYSFSASIFYLGSIVGSYPAVLMAQRFPIEKVASAIFPVWGVCLMCSAACTNWQGYYAQRFFLGFLESGISPMFMLVVGGWYKRQEQALRMVSPLINYGLGQISGGGLNRWQYMYLVAGAITILWAVVIYFFMPSDLICAKGFTDTERYIAVLRTRANNFGVRNTHFKAEQLWESLLDIKFWLIFATAFVMMIANGPVSSFIPIIISGFGYDRLNSLLLTLPASPPCDTCAPYLAYRVPRIRTWIIAICQLGTVLASLLLWLLPRGAEGGFLFACYILASFGGGYAVLMGLQIANTGTPNDLPNYAPVYPPGFTAVLITSIVAAALTIVYRYICIYENKRRDKTSAEGFENAFEDDLTDKKNPQFRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEA6</accession>
    <name>A0A9P4PEA6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_523181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEA6"/>
    <dbReference type="OrthoDB" id="5793281at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38599">
        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38599:SF1">
        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16314" checksum="814E7273ED7CCCB6" modified="2023-09-13" version="1">MSNPNSPNVVKVDGVWQIEGKPREDFKILQTFHPSNLPGKTMIVGTVEMAPGSAPPSPPRRRSHRCRTYRGHFFEPDDGNEPITSSVGEFWYEAPGCHHQRSENDGDKKANFFVTMIVDDEVIKDGYGSVFVLDKEVEAGEKPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEM3</accession>
    <name>A0A9P4PEM3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_434077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEM3"/>
    <dbReference type="OrthoDB" id="4657524at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="3">
        <location>
            <begin position="63"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="288"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2442605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="44922" checksum="D37722CC9A31DB29" modified="2023-09-13" version="1">MKYAITPLAFAVGSSALAIRQSQQCVQLQASGGASGTLEQLSDGQNRVGGGHDAACYCLDGNGGFTDSNGRGCILTPPTTQFQCDVGASPTNGFSVNGGSVTYNGNPKFYACPVNDNGEYNVYTQPAPGQAKCVEITLGAGQSCGAGNGGGASQSASQPAQSQPPQASQPTASQPGYSVPPKESQPPKETQPPAPAPPAPQPPKESQPPAPAPPAPQPPKESQPPKESQPPVPSQPGYPVPPKESQPPKGSQPAPSKPAPSQPAQSSPPSNGNGDSNGCPANLNGEYQYPHLIVPVSSSQPSSAPGTSYNGKANGDVCSLFNFDIPQSYSGSSCSLVFLFPQQKDLETSSYTVSGSGGLEFSKCETNASEKSSWDNKGTCTTVKTVDNVTPGNSYTVLSESCPAGQTVTFQMCATGGLSLDYFQDYNPSPIGAYVREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEU9</accession>
    <name>A0A9P4PEU9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_70320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEU9"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000022">
        <property type="entry name" value="Dynamin-like GTPase Dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="27"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="719"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="533"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2442602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="806" mass="89425" checksum="25CCAA80E62D0DF0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF76</accession>
    <name>A0A9P4PF76_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_361226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF76"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2443919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="201" mass="22304" checksum="053351C3258F0A02" modified="2023-09-13" version="1">MPVPYVTETVAGGWKTSDIFSRLLSERIITLNGEVNDPMSATVTAQLLFLEADNPSKPISLYINSPGGSVTAGMAIYDTMNYIRCPVTTICMGQAASMGSLLLAGGTPGQRYILPHSRVMIHQPSGGYSGKASDIADHAKEILRVRDQLNKIYQKHLTKPRTLEEIEKYMERDYFMDATEALEFGIVDQVLEKREAEKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFA0</accession>
    <name>A0A9P4PFA0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_432056</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFA0"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040538036" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="335"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="486"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2443965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="545" mass="59056" checksum="598CD3DAAFAAE811" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGF4</accession>
    <name>A0A9P4PGF4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">N,O-diacetylmuramidase</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lysozyme CH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_434003</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGF4"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2442514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="226" mass="25100" checksum="F8EB005A184386F3" modified="2023-09-13" version="1">MKLLDYMPFLSTLLDRGTPYRRTIQGLDISRHQNKPNLTEAHTVGLSFVYIKATEGPTYTDPKFNEHYREATDAFFMRGGYHVARTDLSDGATQAQFFLSNGGGWTTDGKTLPGLLSIGLEDNCAGLTPKETQEWIKEFVETYEEATKRAPVIGTRNEWWVECTGNTPEFNEKSALLLANWGDGVGMIPGGWQFATIWQYKEGGAWGGNSNIFSGDANALRKLADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGG3</accession>
    <name>A0A9P4PGG3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_432766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGG3"/>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2443522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="490" mass="52219" checksum="A503489C7620A8D4" modified="2023-09-13" version="1">MQTVLSPLVGRLSDVLDRKLFASIPPLIAVAGSIICAKATSMQMLIGGGILVGFTLATISIVQSIPSEILPLKYRALANGFAFLGGAVGGLVGGLGAGAVTNVDPTGWRNIFWIMAGLHGATSLGFFAFYWPKKRTEYPSMSFKEYVWACDPIGSVLFIAGATLMLLALNWAGGAYRWSDPHVCANLVLGIVLILAFCVYEWKGRSDGMVAHVFFSTGPNFWLATFAFAVEGWIFYSAVNSVTPQIILNLGLETNSWDIAVRQMSYQIPSLTFSLVVTWWATRFKDLKSPLVFTYVVFLVTTICYANIRPSWNVPQIVFAVLAGIGTSGPLTLLVACIQFTAPHAFLSTATGLAFSARAIGGAFGSAVINAIINGRLNSHYASDVGSAATAAGLPSSSLPALLEAMEAGSFSGVPGANEGIISAALEASYWSYARAYRLGWWSVVPFVALAIASVACMSGVKDLMTEHVEATVERDVVEDQGKEKGLEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHH9</accession>
    <name>A0A9P4PHH9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_416785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHH9"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="600" mass="66775" checksum="54445702C887CB56" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHP2</accession>
    <name>A0A9P4PHP2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_521502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHP2"/>
    <dbReference type="OrthoDB" id="3788551at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="362" mass="40325" checksum="E7558273314D7537" modified="2023-09-13" version="1">MAQGTSASRAGKASMRTRAHSDSDPAESDISDQRPVASQSKGKKPVAVARGNPTANLDHGQASIEGTTDILTDIYEYVRGVDKGHDLLGNLPLTEDYSFDEAPAERPPNYHAEMLFLGEANGVQSWANLRENHVGEGVVLYNYHTIAVVWIRQHSLDQLHLMYPFRVLKVYGVKGTDCLAGLVRFIYRETGKVDSTFAIMARQNLVTALRHIHNDYESQGGARFVEDMQQPSVLPSARYVRAEASTPASGAVDSVFTSAYSTPRSSIAGEKRPHNSDESDMSEEDESYTSEGDNAEAMAEYRELQEKRRIGREKRAKVKAQIRTLEGEVLSTKQEFDGLVEEDDELRERQKEILRATGRWCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHX9</accession>
    <name>A0A9P4PHX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_35168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHX9"/>
    <dbReference type="OrthoDB" id="4924482at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="179" mass="19952" checksum="1DEC97D26D9EFC2F" modified="2023-09-13" version="1">MSNKTRVFVAVYTRPTASDSSTISASKSRPTAQKYHWGLWLEPKGSNGNGTSFDLEDAAAYSSVSSPFGWRLHFDEHKSLPSHMLGRVMIGKMVEGSTEADVANVLMQVQMPCEAGSPVGDAVEWIKRVIYELQEMGCAEMFSIDAFMEEALSHAITWHGKKGRKEPEKVNFTWSRTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHZ9</accession>
    <name>A0A9P4PHZ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_473464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHZ9"/>
    <dbReference type="OrthoDB" id="10688757at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="211" mass="21717" checksum="2E440C4FCAF84BA6" modified="2023-09-13" version="1" fragment="single">SSSTNVTSSTATTANTTVTSTSSGTASSGTITSTTSCTGYWNTTTKSINPTSFSSSNSSVVPSSTATNFTSSFSTTSANSTTFVSSTTSTFTGPTNHTTTLVPSTTSTFTTGPTNRTTTWTSFSNTTTAISTSSVDTTCNTTSTVRPTTTTKCSSATIVETLTTATFSCEPRKGCSSVYVTRLFTRVVELLPSSFEAFGTSYSSLPPPTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIM8</accession>
    <name>A0A9P4PIM8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Taurine catabolism dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_432807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIM8"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF20">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="45"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2443576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="359" mass="39922" checksum="85E8FFF67594A63B" modified="2023-09-13" version="1">MPSVKRLHLDAQNDSNSSIMGGSPSARSRLLEPLAYTGSLGSFKNQDLTPVIGREYEGLQVTDLLKWGDNMIRDLAVTISQRGVVFLRDQQVTPHQMKELMLRITELSGCPESSGLHVHPLTEEGSELGDQISVISSEKQKQGGGLTHQLSDVSRFASAGWHADITFEPVPSDYAMLKIHTLPATGGDTLWASGYEIYDRLSPAMQQFLEGLTATHDAKFFLDEAERLGNPIRKGIRGNPLNFGEALTAIHPVVRTNPVTGWKSVYVNKGFTKRINGVTKDESDLLLGYLFNIVTQNHDAQVRFKWRANDLAIWDNRSMWHCATYDYHDPRAGDRVCSLGEAPYLDLKSKGRREALGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIP0</accession>
    <name>A0A9P4PIP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D123-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_432820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIP0"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="393" mass="44965" checksum="AD4D7700622CA054" modified="2023-09-13" version="1">MSTAHADSAASVVAASPDLPKQLPFPPVTKQHILNCSYHIWHPKYRAITPKARLVPLPDAFLDYLRTDGIVLPPEDNDNPEWSDADSGIFSGADNDGDDEGPGQDPSTHWRETHEAVEAAIEELGGKVAPKLNWSAPKDATWIAATNSMECRTPNDIYLLLKSSDFITHDLQHAFDDTTEGDTPTEGDAAIPYHLVLRKWIVLNPSVEFRCFVRNRKLITICQRDLNHFEFLFKMEDKLRQTIQEFYDVRLRDTFPDPNFTFDVYVPPPHDRVWLVDFNPWALRTDPLLFSWMELLTLEEPLLPEAEDAPDKNFEEDEEDEVVELWQPEFRLIRRDDPEAYGFSTPQYSAHKLPRDVVDASSGGEGMMREFADQWKEAQRLAEQQANEASEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ12</accession>
    <name>A0A9P4PJ12_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_431830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ12"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="166"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="546"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2445066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="728" mass="80199" checksum="B6BAE2E456C00E93" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ34</accession>
    <name>A0A9P4PJ34_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_432179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ34"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000058">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2444093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="297" mass="31888" checksum="217E02AAF79653AD" modified="2023-09-13" version="1">MPLLRPAVRLYTLRIQRRAYSSAPSPVINVTNVPAPHSGSIRILSFNRPAARNAISRQLLAELTHQVNSIHNEGEKGSTRALILASDVDTSFCAGADLKERATFTQEDTTNFLTTLRGTLNSISQLPIPTISALAAPAFGGGLELALTTHMRVFASTTTVALPETRLAIIPGAGGTYRLPALIGLGRARDMILTGRRVSGPEAYFLGLCDRLIEITQEEAQTEGAARKKVLAESVNLARQICEGGPIAIKAALIALDGCALGEKAENPAYELVVKTKDRDEALAAFREKRKPVFKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK07</accession>
    <name>A0A9P4PK07_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription initiation factor-like protein TFIID subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_432402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK07"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="8">
        <location>
            <begin position="97"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="440"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="494"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="536"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="578"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="628"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2444344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="738" mass="80828" checksum="9A4431EB7C36CC4A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK79</accession>
    <name>A0A9P4PK79_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_484235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK79"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="172" mass="19965" checksum="B7EB96C308842F04" modified="2023-09-13" version="1">MVGLYSHYSVYIISRYKISKAYLAARDETPEMHTTHHVLDSVHDAAKSVQRSDAGLLVVDDFHVPDNYYRVIHSLKATQWTQARALEHTRQILAPRGMHNRPTRDRVGIAAFHTNSTKIFKCVESKEEGKYPGLGWTGDLEGEEHMWQFWRMEEIEYDSHETVVTNHATWEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL69</accession>
    <name>A0A9P4PL69_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_483182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL69"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="124" mass="14562" checksum="50A40A57F81431D6" modified="2023-09-13" version="1">MYVERESATERPVAHAAIGSERIVTEIPWSIRPEEPAKLQNITPPTDPHQHTHVKVNKEHLAIDTLLYYDIPYEVDGVDSDYISILREMEPAETEVLFEHTRRLRSRLLIEERREEKVPRTLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLY2</accession>
    <name>A0A9P4PLY2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_431118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLY2"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="77"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="223" mass="24197" checksum="28DF61794CE14A5B" modified="2023-09-13" version="1">MQTNRKGAPAKTPRAGGAGLSTKQSQQLPKNWPTHVPYLRLPSYSKGLTDDAMSVLVLAKADLPSGEEARQVAAPYSNVKITSIGDESHPAHGQYGLFASQNLQPGAFLLPYLGYVHDHSETDEKSDYDLSLDRDYGLSVDASLTGNEARFINDYRGVSSAPNAEFKDTYIDLGNGKIEKRVGIFVLCAGKSGKNSRGIPKGQEILVSYGKGFWNERTATQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM70</accession>
    <name>A0A9P4PM70_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_262237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM70"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040371706" description="alpha-L-fucosidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="8">
        <location>
            <begin position="316"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="781" mass="86752" checksum="A0E23F79C7A880E5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM94</accession>
    <name>A0A9P4PM94_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_263246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM94"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="93"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="361" mass="39147" checksum="D4AD2137F05C74D9" modified="2023-09-13" version="1">MCDFSEYGGPSEEWLKIEKALPVPFFDFGSDPKAARDMVNAGREDASAKLMEQLGPHVRMTDHSIPTRDGSTIEARSYRAASKSDDEVLPAYLYFHGGGFMFGTLGTGDAACANTAINTGAVVVNVNYRHTPEHTFPTAWNDSKDAFIWLHKNTDKLKIDPLKVVVGGISAGGQLTAALVLEKHLGKNEALNGLPEIAAQVLIIPALAYHETYAEGALKWMKSPEISSIVENENAPILPMSTVRYFMELLKIPKLDLKDTRLNTLTAASAENVKGLPPTMLGIAGLDPLRDEALLYGKLLSEAGVPTEVRLFKGVPHGHRTFGPALKEASAQWDKAIEDGIAWAHKKPAAIGKFDIKVVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PML1</accession>
    <name>A0A9P4PML1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_429490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PML1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="68" mass="7782" checksum="56BE22781BC41DD1" modified="2023-09-13" version="1">MYMLKRQLASSDDIFHDAIKRYSRISSLALAAALYTKCPRELRDMVYYYLLDGPGAMVARAAAQVQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMM7</accession>
    <name>A0A9P4PMM7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_472321</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMM7"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000059">
        <property type="entry name" value="Inositol phosphosphingolipids phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2445601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="481" mass="54318" checksum="769B9C862A274269" modified="2023-09-13" version="1">MHERLESPSMIDETSRPPSSLRILSLNCWGLKYIAKLRNERLTEIANQIAAADPPPEIVGLQECWTQQDYDVIREKTKHFLPYGKFYFSGIFGGGLVILSKWPIEESSMTQYPLNGRPAAFYRGDWFVGKGVAYARIRMGPTRRDIAEVFCTHLHAPYETEPHDSYICHRTAQAWEIAKLMRGAAERGHLVIGLGDFNMTPMSLAHRIIETHSRARDIWRVLYPNSSIGAAKDKVEQMRNVPMPNAEYNLTKNGATCDSALNTWRWNKAHSQRLAKGENVQIDPTVDDPNAKRLDYIFFSSGSHHDATNGRPSAEWTLQEANVGMTARHPTLYCSLSDHFSVEATLVRNLDEPLSTTSNGPYALPEAYLPIAIYDEILATISKYDARERIQRRLRLGHFGYQFFLTVGCLIGVWWVPHNYVAFILMLISSLSLSVGVIDGLMGGLFVSSELRALKEFEWEVRNTKERALARAGKEGPPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNF4</accession>
    <name>A0A9P4PNF4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_406249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNF4"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
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    </evidence>
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</entry>
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        </recommendedName>
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                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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        <source>
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        </source>
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                <person name="Castanera R."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
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                <person name="Cannon C."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP97"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="452" mass="50460" checksum="21932B410EEDDD93" modified="2023-09-13" version="1">MEGLVEHNYATHAFLVASRVLECSCICTNCRQPSNHFKEMSNEFHMSAEEVLKACNLWGFLPYPARGYASFLPAAYTALPQTQDTISKSSDVEDCLGRNVLIRFVDYLDEETACSRVRQFVDSNNATACDEANDRTRAAINHQDILGRSILHPLHFAAAVNFISICEILVHDYMQPVNLTHKFGFTPANYANGKRFNKVAQFLYLSALASTNKLHTAVEKGDLAEAQYALNLGADPNSKYGNTHSALEKVICRHDLLLLQTLGDCPRTLFDLRSDDSLTPLLKAVDQGFTKGVEYLVQCKSMNINAMSAEGHTPLWLSILRGNTAIARILLGRHDVDVNGYDAAARLTPLMKAALIPQPEIIDLLLSRKDMNVNALDHDGRTALHVAAGLGYAEVLERFLKRADVDIHVRTRQGQTAVEIARVRNHLDVVRMLEVWTTQKEDERRLELVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPU4</accession>
    <name>A0A9P4PPU4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_511336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPU4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040271823" description="Secreted protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11395" checksum="9A6BA23A81CBC443" modified="2023-09-13" version="1">MYLLPAPHSLSFTLILATLVGSKLSVQMEQANRLVSLHSRTFPSHTVSAPTPRRSRYEAMARSPRSARQKGKKSMGVDKPRLNSNGGSLARRPRRNWVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPW2</accession>
    <name>A0A9P4PPW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_441973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPW2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="200" mass="22171" checksum="69A86C2CDD812392" modified="2023-09-13" version="1">MTTPEHVPNGAGYVLPPSGLVYQGLLLGTEYLRVDWACKWGDSLPRPGKPQRNGCRQQRARTPEAALAERRKSTVLHGFERESEAQDAARADDAALGTRPEGTRHNSPMVLVSDPKAVAHRIQRGASPVVSFRCAPFATNTHAAGTLSSYHVALRRTNWPLSPTHRTSEDRNRNFESHKHEGTFGEKHRAKFVGTCTRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ53</accession>
    <name>A0A9P4PQ53_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_470138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ53"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="48"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="363" mass="40473" checksum="372687BFF653677C" modified="2023-09-13" version="1">MPAVGSLTPEQVVEAEERIRNAGRIPMISLELSLGILFGLAVLTCTGRMIIRLSSRGRLALDDGLLIFALFCLAFSTGIMYKIAPNYYIVQALIRGDPAAKILASTQGYRRLTAHYNWSFANIVLSWTTIFFVKGSYFALFYPMMSVMSKHVLWFYWAAAAFSAASWFVLAFGSNFILCKELGTAAVKCYFNNSRHGMLTLLAVTATLDGLTNLTIVIIPIFILHKSTMRGMVRLGVGIFLMLSVFMLICSIVRAAGVYYQGIIDCRWQSYWCHVEACIAVIMGSLTVYRSTLVGSNEVPNKMQSYLYKWFGITADQSQDDMSVLMQNAAKKGMQPEQDISNEETLVGTYNDERKSTVSVKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQK5</accession>
    <name>A0A9P4PQK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_480565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQK5"/>
    <dbReference type="OrthoDB" id="4775599at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040499546" evidence="3">
        <location>
            <begin position="30"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="268" mass="29486" checksum="B6546FCAF4488CC3" modified="2023-09-13" version="1">MLSDSLSGFLSLPSSLLSLITLLPMSASGQSTTATSGLTAEATPSIPTSLSRTEHTRSMTTSFISSALSNTAASATSTSTPISTDILPGTTSTEDAHESAFKYYWLILALFGVLVTLSLWWINRRRTKRKERMRLSGRNALARDMEGWVNTRRWYHGAWRPNETRLFTRREEGLNEQGEAPPPYQPKGDVTVAQDPATMISIPLRTLSREQVDAGRPPEYHETLNRDGENAVRPATADSYTNQSATGSPPRTSIRNPIQDRNDRGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQR6</accession>
    <name>A0A9P4PQR6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_483330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQR6"/>
    <dbReference type="OrthoDB" id="5206740at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="293" mass="30598" checksum="6FBF376733228119" modified="2023-09-13" version="1">MATSTAQLPILTPRQPALSQRPSLRLDTQQLRTFGKGSSLRLDTLSAVSPTARNTFSNAYAPPASAAPATGRPSKLRLSIDSSCNAPTSASTPSSASTLSSALTSASTDSAAIIIPYKQPHNVRSILSNGPTPRKMASARPLFPAEKRVSFRAPLEEEIKTVKYTLAHSDIESSVSTISSLATTSSEESETATPLSINTKPTSTASPTLSIPSSSSSSSSSFASLQTSPRPGGPRAGDKRDSSDSDSDSCPETPVAGRRKRRRDWRWTLGPLPSDASTSPSASTSEATSEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQV1</accession>
    <name>A0A9P4PQV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0047-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_352153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQV1"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="210" mass="23506" checksum="D5DA98F80999F43A" modified="2023-09-13" version="1">MPPAHPQGTISHCTTFLILCGFFLALFPSLFIRLTWSPYNYIFPPPPPHAPPVWCSAPNICAPPTTMSWFQKTLTLPSKSRGSYLITDTIVRDLPELKTYKTGLLHLFIQHTSCALSLNENWDEDVRADMSDALDRIVPEDRKGGLYRHDAEGADDMPAHVKSALVGASVTIPITDGRLNTGTWQGIWYLEFRASRHSRKVVATIQGEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR67</accession>
    <name>A0A9P4PR67_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_218030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR67"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2448697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="910" mass="99613" checksum="3E45F72DA9B9F2FD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRB0</accession>
    <name>A0A9P4PRB0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_482020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRB0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="241" mass="25725" checksum="A9079DC5916F67F8" modified="2023-09-13" version="1">MAWKTKKQEKAQDDLVARKSSLHLLPKASPPPEDPTPPSYAPSTTDQPPPLKSPNAALSDPSLHIRSTTSTSLPLLHNPDPPLYRTTTDPTPLSPTAPLYSPTTTSPIPKKPHKTLPRIQALKTTLSDVKTSIKDSPAPSVVKAAWSGGLEARSSFAMVGPAAATGVPGLVVGAGLVAWKVGKGARKVYKEEERERGERLVREGKAWRDGQGRVRRGGEEVEVVEVEVEGMGKKGKKGGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRF1</accession>
    <name>A0A9P4PRF1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_428870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRF1"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2448875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="242" mass="24268" checksum="E9B5525296E9E399" modified="2023-09-13" version="1">MSFTPPGMNPNAGMSDQEAQMVKMMQGAMESCAGKTVMAGVMGGGLGAMFGLFMSSMRYDTPMSQPLAVPNAPAPAAAAAATNATSTAAAGAKPTPTPTPAPAAASAASSASSSAASSTITHPSFAGQMVQTPTGSVPLTDLPLRQQLKHGLRDMYRSSISSGKNFAKVGAIFSGTECAIEGLRAKNDLWNGVAGGCLTGGVLARNAGPQAAAVGCAGFAVFSAAIDAYMRMPEDERSRPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRU7</accession>
    <name>A0A9P4PRU7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="2 7">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ALG13</name>
        <name evidence="9" type="ORF">P171DRAFT_186121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 7">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="2 7"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRU7"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052474">
        <property type="entry name" value="UDP-GlcNAc_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="196" mass="21494" checksum="00A9C40627923C9E" modified="2023-09-13" version="1">MSKLCFVTTGATAPFTKLIEAVLSHASLDAFLQCGFTHILIQYGTAPDVYQSSAEAARQYLKQNGTEQKLEIDGIDFDSSGLFEQFKLVQQTQGLVISHAGSGSVLEALRFQLPLVVVPNTALLDNHQEELAVAMDRAGYVIHGNVDHLAPAIKDSERFRTQMAQFPPVTAGKERKVKSFANIMDETVGFTDFNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSI3</accession>
    <name>A0A9P4PSI3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Heavy metal translocatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_460687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSI3"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056236">
        <property type="entry name" value="HMA_PCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF4">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24534">
        <property type="entry name" value="HMA_PCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="832"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="PCA1 HMA heavy metal-associated" evidence="10">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="9">
        <location>
            <begin position="382"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2449402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="897" mass="98138" checksum="B386083A48CF9843" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSK6</accession>
    <name>A0A9P4PSK6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 25">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="4 25">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">P171DRAFT_403048</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="4 25"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSK6"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 25" id="KW-0288">FMN</keyword>
    <keyword evidence="11 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="15 25" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14 24 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 24 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="285"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAF2450579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="744" mass="83851" checksum="4EF8381037D5EBD9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT28</accession>
    <name>A0A9P4PT28_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF567-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_451867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT28"/>
    <dbReference type="OrthoDB" id="97518at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF161">
        <property type="entry name" value="TUBBY C 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20161" checksum="FC59039AEBBF99D3" modified="2023-09-13" version="1">MKPYPTTIVLKEHVLSLTGDTFSIKLEDGTPILQVEGKIMSISGRKKVRDMSGNHLFDIVKEHLHIHATYACEDPQGQKLMEVKNSFKIFGSSATATFTDKKGIQHVLKMKGSIFDTHAEIIDEARNGATAARINRKLLSGKDIFFGKQTYAVQITEGYDQALIAAMCICLDEKNNESRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU72</accession>
    <name>A0A9P4PU72_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_346860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU72"/>
    <dbReference type="OrthoDB" id="4078573at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF40">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="578"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2451434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="667" mass="75941" checksum="30CB1B6EF6985342" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUX8</accession>
    <name>A0A9P4PUX8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LNS2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_144617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUX8"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="417"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="625"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2450707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="755" mass="83378" checksum="3B886D9857DF166D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVB2</accession>
    <name>A0A9P4PVB2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FMN-dependent alpha-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_450719</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="25826at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF143">
        <property type="entry name" value="FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASE PB1A11.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
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    <feature type="binding site" evidence="5">
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            <position position="299"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
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        <location>
            <position position="302"/>
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        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
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    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="330"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="353"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2452050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="404" mass="43862" checksum="D5DC7A9743B30410" modified="2023-09-13" version="1">MVRFVGFFGIFGMFEIYFNHTLYNQTPIASTNYAKLEASAKNLLTPEAYDYATGGAGLETTVAANRAAFDRWQIRPRVMRPVQPKRNLTTTLFNRTVPAPLVMAPIGVQTLFHPKGERATAAVFGQEDLPYTQSTASSTGFADVAAANGAGKPRWYQLYWPSDDDLLRPYLRTAKENGFEVLVVTVDTWDLGWRTRDLDRGFFPFIGGVGVQIGLEDPVAHEKLGFDALAANATEEQKQMAALYHTIVSSRGVSPVWENVGKLREIWADGPIVLKGVQSREDAELALGYGFDGIIVSNHGGRQIDGAIGSLDALPGIVEAVKGKLTIGFDGGIRSGADIFKALALGADFVQIGRPILWGLAHEGEKGVRHVLKSMLADLEITVGLAGCASLKDVNQNLLVARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVK4</accession>
    <name>A0A9P4PVK4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TeaA receptor TeaR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_205374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVK4"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="39"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="62828" checksum="5CE2C61D0D4E8D18" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVU3</accession>
    <name>A0A9P4PVU3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_440283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3772546at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="241" mass="27567" checksum="C054ACD74912CD09" modified="2023-09-13" version="1">MSLEFSDAQKQALAGYGKPFPANADVRRWAFQDRMDLLFSYDLITIFLEAEASWGPVCSEICVVPKYTLAAVSPIFAEHLLQKPELESFVFDVGHMDKALQEEHRKALNSLNTWLLNLATHTISDLKAPTFYSEISLRHIARQLGMRFYLTDRSHELVCGAQTHTLQPWQITELLYASSVDIDATFPIVMENDPLLGYLARKTVATADLLWGDERNEAYNWLRRKENKALESAMQRLQEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW02</accession>
    <name>A0A9P4PW02_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_450355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW02"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF92">
        <property type="entry name" value="OXYSTEROL BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="471" mass="52434" checksum="B1252C66925CF65D" modified="2023-09-13" version="1">MSNSITSNRSTLKEFLASIATIQGDLSNITAPPFVLGEFSTVELPQYWADHPSLFVAPALEKDPEKRALLVLKWFLGSLRNQQYASRREEDGVKKPLNAFLGELFLGSWKDESGETRLVSEQVSHHPPVTACHLWNDQRGIRAEGFTQQEITFSGSVSIKQKGYAILHIDEYEEDYLIPVPNVKVKGIVSGTPYPELVSSYSIISSSGIVSEIKFEGKTLLGFGSGSKNGFEARTFRTAAPAVEMYTAKGSWNGQYSIQDARSGEEIERFDVGAQRSVPITVVDRSEQDPWESRRAWGGVVDALRKGDMKGTADAKSIVEEGQRQMRRDEDARGEQWQRLFFRRQDNDPIFEKLYAADKDSFTVDPEGGIWKIDSDAIVNVKKPYRGDLLPTGQVGQDIPKAEQQLHSEQFAVASTSPESTGGIQPLKLENETGDSQEQVTPDRKIGISPEEIQDTQVEAMLRAKYQSAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW61</accession>
    <name>A0A9P4PW61_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_515562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW61"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="53121" checksum="E1DA110EC53EEA15" modified="2023-09-13" version="1">MQQEFCFVNGTHVDKLTKKRMRRHVMMGKNAGRTIQRKSRRDIVPYQVTKIAAVSSVAICQQPAFDRYAYVDNFREDSIYNDVLFGLSFPVQLTSHFAEVISNFFLFIAHKLYPIALGISMEKSKYTWMSILMSDKAAFYCNLALMQACNELFLGGGEKSPEAMYHLSNSLKYVRKRLESEEALSDSTMGIVMSLITQEQCRQQHKAARIHLDGLSQMVKLRGGLDSLEGCLPILLKACKTDLMYALQCEDTPRFYRSKMPHVISLLRALDLPFDREAARKQVQHPKLDPALLDVLIDIICASTLFSDLPSTQKVDLYLFQELLVSICYRLLAIPYSHHPPRIEDSYHVGLMIFMMSLFLQVGSQRIMSYRNVTRRLKRVLESDFLDGEDDLRLWLLMMGSVWVADDEDADWLMPMVCAQTRKMELRSWSEAREVVERWPWIGALHDALGRLVWERARCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWB6</accession>
    <name>A0A9P4PWB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_493082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWB6"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040352908" evidence="1">
        <location>
            <begin position="17"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="111"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="401" mass="45469" checksum="0C600FD0A960EE94" modified="2023-09-13" version="1">MGPLHLLLLCSPLVLCTHTKATSQCENPAHLFSQHQTICAPTISGLRPDFEWSLEPTCSKGATRTYCAHTLMRYRNNRGLSIIGTSKAAQGVLKAREHLLDEEERFLDTEDWFEVRSIRGKGKGVIAKREIKKGDMILLDSPAIVSSARLPLHVTPSEGSELLETAASKLPREDYDTIMALDKPSEITGLDTILKTNSFSCQFNDGGVGDEYLCLFPQVSRINHACQPNANAKFIPRTLLMEIRALRDIPPGQEITISYGKVDLKYAERQRLYNENWGFKCTCNLCASGIYKIAESDWRRERFAQLHDQLETLTAETYDTERIIQWENEVFEISETEGLEVLVTEDMERMAYVYASLRKQSEAQAWGHKAKKNLLQWKLGPNDTSDDLKRVEELLVELQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PY54</accession>
    <name>A0A9P4PY54_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_439542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PY54"/>
    <dbReference type="OrthoDB" id="10488840at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="330" mass="36163" checksum="DC2576EC05CF0B1B" modified="2023-09-13" version="1">MFSTKGESYAFLAILIVVIVVSSATTITWVILFRNRNRLSDNAPPTDKDNTIGRYWPFERTPKSDVENATPRISPGQISEPSDVRRLNLEERLVVESSDKETYAQAQRTEADKTRSLRVFGVVDGRRETTSLAVDCIANRPILTQEKMLLLNLAFISAPAGSCSNLSSSHTATITAPKIRDPPATNDTLPEKVRNERFHARDITSLVFGSSIPSFTSPNQDATTSAMSTTSWTLSATPSVTSTPLPEISYEHHSDGSAITLAILVSIIGGALLLTLAGWAWRKQKNKKSFGPDHHGTELAKLKILNAGSAPSGARRHYNRDTVELDARPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYI0</accession>
    <name>A0A9P4PYI0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_1488</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYI0"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="468" mass="50983" checksum="6EA35CA89C44B0C3" modified="2023-09-13" version="1">MSVETITTISPVTNKPILTRNGLSDADLLSIPETAARAFESYRRTSLSDRQAIVKKALKLLDERQDALGKELTEQMGRPINYTPKEVTTAVARGEYMLKISEEALKETEGEAEKGFKRYIKKVPVGPVLILFPWNYPYLTLVNSLIPALLAGNSVVLKPSPQTPTSAEQIKQIFADAGLPEGVLQIFHSGSITQIEAIARSPKIQLVCFTGSVANGLAVQTAASDRVPIRVGLELGGKDPAYVRSDVDIKWAAEEIVDGAVFNSGQSCCSVERVYVDEKIHDEFVTALQDVLKGYKLGNPMEKDTHVGPVVSSRSADSIRAHIKDALAKGAKDATPDNASFKSPPADGNFVAPTLLTNVDHSMAVMTEETFGPVIPVMKVKNDAEAIKLMNDSQFGLTASIWTKDTDKGHELVDDVEAGTVFVNRCDYPAPDLAWVGWKDSGKGQTLSKFGFDQFVKLKSFHVKDYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYT6</accession>
    <name>A0A9P4PYT6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_515380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYT6"/>
    <dbReference type="OrthoDB" id="3790858at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="382"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="532" mass="60813" checksum="058DB26D0A13A9D2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYY5</accession>
    <name>A0A9P4PYY5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adaptin ear-binding coat-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_425941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYY5"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000465">
        <property type="entry name" value="Adaptin ear-binding coat-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="269" mass="29316" checksum="4B3D092EC1ADC1AC" modified="2023-09-13" version="1">MNTDPLTGEPLPPTAIQRILYLAPKVHVYQIPPLTSTKGYQASSWTADPKRQIFTARLRILETSIPSPTATDDSAEKVSTTLLLEDPSSGQLFAAAPYTAPNIVEQALDSSRFFAITVVGEGRKAVLGMGFEERTEAFDFNIALQDARRALGFEPNPNAAAPGRKAASKAAEEPKRDFSLKEGQTISIKLGGLKGRRERREDDSKSPEQPKSEQDALFSIKPPPGSGGGFLPAPPSAKSVKEERRRSRQSFEPKPEDLGFDDGEFGEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZ53</accession>
    <name>A0A9P4PZ53_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_426055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZ53"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="200" mass="21584" checksum="AEE3023447799618" modified="2023-09-13" version="1">MPSHPSAASPNFATTRSILAHIAAAMPVQFLRRLVRPSVLFRTSLAPAQPFRPSIASRLPKSPAFGPLPASRAHKCTLIQVLRNGRTQQRARKLRSPQLAGRPELKGVCLKVGTTKPKKPNSGERKIARVRLSSGKVITAYIPGEGHNVQQHSVVMVRGGRAQDCPGVKYHLVRGALDLGGVGNRITSRSKYGTKKPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZJ7</accession>
    <name>A0A9P4PZJ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_493915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZJ7"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000331">
        <property type="entry name" value="FAD/NAD(P)-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF187">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="125"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2452203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="440" mass="48902" checksum="3E9C30E52C4029CE" modified="2023-09-13" version="1">MAVPETNGARPKTGIKVIIVGAGFGGLTAAIECVRQGHSPVIYESFPSLKILGDIISFGPNAGRIFARWENGDIARAMRKISIDLQAYGFNIHKWDTGEVVINQKSPPRDETAPVFNGHRGELHEIVFNYAKKLGVEIVLDSRVDNYWETEDAAGISLGDGTRVEGDVVVGSDGVRSKARTLVLGYEDKPKSSGYAVWRSWFSNEDMLADPETRQFCENGDTFNGWIAGPDVHFLFSTLKGGSDCCWVLTHKDEHDIDESWSFPGKLSEVKEVLRDWDPLCTKIISKTPEEKLVDWKLVYRDPLPTWVSGYGSAPGHGRICLLGDSAHPFLPTSAQGATQALEDGVTLAVVLRKAGKSNIKGGLRAYQDIRYERVRKVQKTGETTRDMWHNTDWEKVKKDPQSIAFPREDWIFSHDAEKHVEEVGDEIIAKTSTSVEQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZW7</accession>
    <name>A0A9P4PZW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_401823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZW7"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="712" mass="79904" checksum="C56D00D33300B4EA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4N8</accession>
    <name>A0A9P4U4N8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_506495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4N8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="188" mass="20160" checksum="B73FE638F2E3CB6E" modified="2023-09-13" version="1">MTVMFSSLTLKRSWPKRADSGGSVVRGPSERAPDIDTSVESLNFTVHTVRVEKVKRDKLCAYSGESFNINLNWCIMTVSDMKEEAYPASVSYVTGVVSGERGTARPVRVSTLAALAGVSFNALEIILMKEEGKPGLSEPCIGPGLDRSLKTRQTNPGFEGRTVVAAISFGSGSSGAGILYSNKFSLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5S0</accession>
    <name>A0A9P4U5S0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_181801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5S0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="117" mass="12814" checksum="C65BD6819AB75722" modified="2023-09-13" version="1">MGATVATTGLWAAWTGLQEIVTRHATLPNTSGQDPTRPTDYPSCDRNVMGKSKPVYPVLHVTAIGRPRACWPGRKQPCLTWVLRLQSHRPFGCSSASLSFMGTFLCTLLCPRPLAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6P1</accession>
    <name>A0A9P4U6P1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_436578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6P1"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="174" mass="19191" checksum="7D5A6F4182981037" modified="2023-09-13" version="1">MTITPATHADAPSIAAIGSATFTTSFAHSMPEKDLQAYLLTSYAPSVIHAELSDTRENSFYVACLADGAVAGFLQVKHRTSDPCLPPELKLVEIHRVYVATEHHGRGIGGKLLEHALEVVRRDGESQGAWLGVWEENLRAQKFYAGFGFAEKVGRHAFTMGECVQWDEIVLFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6Y1</accession>
    <name>A0A9P4U6Y1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_501842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6Y1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="427" mass="46228" checksum="C15E959525BB25AB" modified="2023-09-13" version="1">MANTQPDDALRIALDMVVILHNVDLVEQMLEKELSPAAKAIIERVATGRLDVSTADQHIRRLLSQRGGEADLAVTSALDLLSTGKGDLELTEAILGVSMTTQMRIILNLVISKQLTPPYAHPLLMRLITMSNGNNEEHSPRSHEMEQDSTPNGSETATATGNSVIKTESETNVTTRAGAEEILRGREFGPLPTVKVNKIPHSAAHEPPVGFLPNPFLPNPFLPSPFPPSPFPPSPFLPSPFLGAATTNTSSANASPPPIAMKTAPHWTSHPPARLDSNQLAPAPRIQGPPENLLVEQRKRARSDDSDNGRRDIKRAAVPTHRRKDADWNFEDMIQHIIQLTRKYPSAEQQRMKIVPKEAGNFVNCDFAPYSSAHPDKSGKVCALALGAVSTDSALLARTAPGVTTLTSTPSDSFGEMARTMKAISSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7T3</accession>
    <name>A0A9P4U7T3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7T3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="134" mass="15393" checksum="DD36D018427A20EE" modified="2023-09-13" version="1" fragment="single">MQTERTCGSVVPLQATQSPIEHRPFKHACTFTKTLLANASHDARRSLHAYPTPRPNLHEINPLEISSNEALAQAPQTQRRVHHPPTLTHGPRPARRQSYHLGSEVVIKRELRYRKPVRDPSTRLLYRWSAQNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8K0</accession>
    <name>A0A9P4U8K0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_86195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8K0"/>
    <dbReference type="OrthoDB" id="10523692at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="176" mass="20242" checksum="8F63F110761FF8C4" modified="2023-09-13" version="1">MSLHVSSCVLVGYEQLRSSPSKLSAVDESDKDMAPHRGSTESLCCSRIYEVRKERAGNDRKEMETRERIDMEKPRKWSQIKDLKVRNCRDRRPRRSMKLATGEPCSWAEKEPLVVLPQHRGVGGEPRAPHTVSPHHHLPEFCFLSQVSVLGDPLGHNWHQHRSWTPTTLHKPMVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U969</accession>
    <name>A0A9P4U969_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arad-like aldolase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_487058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U969"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="310" mass="33734" checksum="DFEC9F84C42332FD" modified="2023-09-13" version="1">MAPSAISTEVLPSLKAKQPIPKSKDDPAKPQTALQAISQGVCLPGIPTFPSFEKHRAWLLAHMAGAFRVFARKNFTEGMSGHISVRDPEFPHTFWTNPLGRHFGLLKASDMVLVDYDGKAVGGNQSRPANAAGFLIHSAVHRARPDVHAACHCHGIAGKAWSAFGKPLDMINQDVTYFYGDAQAVYRDFGGVVLSPTEGEKLAAALGPRGKGLILQNHGLLTVGGTVDEAAYLYTLMEKSCDVQLRVEAAAAAGMKKIIVDGEAAEYTFRMASDPEALYWEFQPDLEYEYEMAGSLFEDYTAPKNLLTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9K0</accession>
    <name>A0A9P4U9K0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_495284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9K0"/>
    <dbReference type="OrthoDB" id="3799798at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="280" mass="30637" checksum="044C9F5018D1CA0C" modified="2023-09-13" version="1">MEQQGNMNEGVTDIANTTILSSPSTPDPVCTPSFSEASTAISTDALPNVDSLSLDESDSTTNAPATLMEDEAPIVTDSEPKKGNKSKLSLNRAAIIAKAQAAKNDRVFAAPSAAAKRSARLKTPNYKPILAAGKGSLTQHEQLRKELAEKMAKKKEEADARAKQGKTRQFLDYQAKKLLQDLPDEAVEELPDNFYQLAMEEKLSVLLEAHMKYRREGKAKGQESGRILGEIEKLEEFQDIERSIRDSKEHEECICDECKESQGDVGGVGRIVGKMDVPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9P9</accession>
    <name>A0A9P4U9P9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_434147</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9P9"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2441458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="141" mass="15960" checksum="ADBE0DC7B69AA45D" modified="2023-09-13" version="1">MLTVLVDIVINLETCDRKTPKADTALEALKHVSLVFSALFMLELLASIWAFGIAYFKSKFHMFDATVIVASFIFEISLQGVEEEVASLIVILRLLRVVKIVDEISVGAEAQMSDLEQRLGSLEEENKYLREELRRRRTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9Y6</accession>
    <name>A0A9P4U9Y6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF1242-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_73863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9Y6"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2441562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="114" mass="13236" checksum="740B70E558E6CA4B" modified="2023-09-13" version="1">MRMRLRTAPHPNERQHTLQNFKQPLCPSQHPPQGTHNPLGTHPYKSALFDFQKLVVVILLLVCTCTYAHHYFPGFMDRNRHNYVMGIFWKCARIGERMSPYIALGLVFMAVSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA00</accession>
    <name>A0A9P4UA00_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_485457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA00"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="297" mass="34674" checksum="361392758086ABC4" modified="2023-09-13" version="1">MPPIRSRAGKNRAVQRRFTPYFGNKIADIFLGDSSRHFTIHADLICKSSPYFRKKLQGNRKEIAGSCSICFDDLDTGDQQLTYCTTCGGNFHEECTTQWFKQSRGRLCPLCRGLWSKRCKNQSVRLLSLCQNDFAVYRDWLYSGHVTYDHAVQQDDFKPMVRAYLFSMYVGDVKFGTAVLQAMLDWYEDKGSYPDQDAVALAYGTYYDEDAIDRCYKENAANNLPGLHRLQRFLVDTYMAVAHATWFEDEDWHAYPHEFLRDLVVAMYYKHPAKNKWNIDTWKAELEAEEWSVQEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA10</accession>
    <name>A0A9P4UA10_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ureidoglycolate hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_432109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA10"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2444019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34234" checksum="ADB9DC2E683FD736" modified="2023-09-13" version="1">MPTKMPAPSIRIPIELLAQPSFSQFGTVIENPAHSPLPRSQLGPLPTTVSANQGSALKILDVTHMSNLYSLAPSKKPAKAIMNMFVCAPRDLRPHEPSESMPSSWGDLDFDEDDYGNADRELFDVRILERHPFTTQTFIPMGLGVQERHTQYLVIVAPTLPASSSRLHIGRPPPYPTPKPKKKNSIKDILARARPSPFTNENAPPPSQFSRLHPSARPKGPGLPDLKNIRAFIATGNQAVTYGAGTWHAPMVVIGARPIDFVVVQFANGVDIEDCQEIELETSKTAEEGIVVMVDSDSSGKVQVQAGVGSVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA53</accession>
    <name>A0A9P4UA53_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_446715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA53"/>
    <dbReference type="OrthoDB" id="10670880at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040430123" description="Secreted protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23957" checksum="DE07DB47ACE1DE85" modified="2023-09-13" version="1">MPPSAEPRAPLLCCAVLCCAGLHAVSPGAAPKGKIPIIVVVKLLLRDVRVPPRAPGVMDRYLREHLHQGPDAIVVTRTSMAANCIVQHNRRYLAPRPSPHAIRPAAAICVLFASYRVSDIRGTRDDHNRLLSCYRATATIVYVARFGPSSSPVALPSSSGPTTSNLLPGPSNYWQRTEPLFVPYRPRSTMMDSASNKRNEGMPARHDRSPYAAKESLCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAQ6</accession>
    <name>A0A9P4UAQ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GCN5-related N-acetyltransferase Rv2170-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_65461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAQ6"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCN5-related N-acetyltransferase Rv2170-like" evidence="1">
        <location>
            <begin position="244"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="348" mass="38638" checksum="A59220C276140D5D" modified="2023-09-13" version="1">MQVYEHPASSPPLQAALTRRLPYSISLSYRIKHPNRTPDAHILATFPSNTSTDSIPQCWAAAYIDRSMRPETELWIFTTGEIPDHHASPNKEGNEFCTECKKAVLSLIDYMGSLPIPPLHPENEPAMELARQHEKEHPQTGPEARYPPGPGLYMRHLLIPTVVTLGGCHQKVVKILAEAGVLCKEFPGHEADLNKFWFKVSDLPKPRDLPEELQWGEMREKDLAIVQARTSIPRTTRTLLSLKSVGVFEKATDEPVAWTFLGLDGSLTTLHTEPEWRGRGIAKAVAVKIFKEHAPGLAVDAEQNAWAHADVYSGNVQSETVCRSLGGKPSVKILWVRIDIGKESISGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAZ5</accession>
    <name>A0A9P4UAZ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_432804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAZ5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="16"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2443571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="544" mass="60442" checksum="0CF4B67659DB505F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAZ7</accession>
    <name>A0A9P4UAZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_49366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAZ7"/>
    <dbReference type="OrthoDB" id="3799195at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="269" mass="30607" checksum="81870FB0814698FA" modified="2023-09-13" version="1">MAGTLSATAKGKARTDDGGAPSSSAVSPPRTPPRRPQPPAQPATPSSSAFPATPSSKHKQSRITSFFPNRKRRLDTIPFELSPAEKRAEKRAKKQEEADVKVLIKDIEKEEREAKRAEIEAERQLKREEQVAAALERQKKARIRANWNSWCERNARPNSKFEIPKADEKRLWKLHRSMTQCDKEFGLKRLELHCLEHCSRPNWHTDGATEMLLYRLDDVERLAWRKEAMLAGVECDNEEELFAKGRSLFLQKQIAKTASKEASTIQADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCA1</accession>
    <name>A0A9P4UCA1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_431767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCA1"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06408">
        <property type="entry name" value="PB1_NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034892">
        <property type="entry name" value="PB1_NoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="464"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2444995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="549" mass="62576" checksum="FA0F8525E8108C48" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCD4</accession>
    <name>A0A9P4UCD4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_29005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCD4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="181" mass="20045" checksum="11849E29039E87B8" modified="2023-09-13" version="1">MLSRIFRGTWFGGNIEVSLGVGPVLNVEDVFECSDGTVVDKNGLHYYCCTTVTRKAMGTQRITTASLRTAKRKPGTDLVQTEAIEEVAAAVATMWLPSRTRVYRGSRRFLWLGNGCIDFAHETQVGQDVEPVVSGTRLLDQANSWSSEGALVRPSPLVARQTIWLRKRICMTRPRASVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCP0</accession>
    <name>A0A9P4UCP0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_482996</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCP0"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2446929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="156" mass="17833" checksum="078359E606E688C0" modified="2023-09-13" version="1">MPKNKGKGGKNRRRGKNENDNEKRELTFKEEGQEYAQVIKMLGNGRLEAQCFDGTRRLGHIRGKLRKKVWINQGDIILLSLRDYQDEKGDVILKYSADEARSLKAYGELPENAKINETDTYGDQGDEGIGFEFDEDRDDSDDSDDKDGKELDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCZ2</accession>
    <name>A0A9P4UCZ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_431158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GLYK kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCZ2"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001691">
        <property type="entry name" value="Probable ATP-dependent kinase TDA10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2445761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="305" mass="34639" checksum="1915766984887FD8" modified="2023-09-13" version="1">MSSLDSNVQQVLELLVPKFRAHKQQSPHPVVLGITGLQGSGKSTWAGKIVDLLSSKYNLHAITVSLDDFYHTHDNLVARKDQDPDNKLYRTRGQPGTHDQQLAHDTLQALRSWDDSSAQGVDIPAFDKSRFNGEGDRAPRPTWPHCASKPDVVVFEGWCVGFRSVPDATLQSKHQAAKAAPPDDNPECIVTLPDHDFAHIQEVNRYLAQYNETFMGPRHFDFFVHLDTEDLRNVYRWRLQQEHAMWKAKGTGMSDESVRTFVRGYMPAYELYLEGLREGFFGEVSGRHVRVVMDRERGVEKAEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UET8</accession>
    <name>A0A9P4UET8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRM8</name>
        <name evidence="11" type="ORF">P171DRAFT_354269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="9"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UET8"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="294" mass="33213" checksum="21E94CAF611BD4DE" modified="2023-09-13" version="1">MAAEPPKRQKREEYKRSLAADDGALPKKKFFRQRAHANPFSDHALTYPKSPAEMDWASVYPAFAVKKPAQGEDVKEIDESRADGQAAHKEEQKKTRAITKDVEIADIGCGFGGLLFALSTTFPDTLSLVTEYVQEKIRALRSQNAENQAYQNIGCLRANTMKFLPNFFRKHQLRAIFLCFPDPHFKQRKHKARIVSSPLCSEYAYVMKPGGYVYTITDVRDLHEWMVGHFAGHASWARVEGSELAEGEVGQCVATMSTETEEGKKVTRNNGQKFIAVFRRVEDPAWLGEEHGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFQ0</accession>
    <name>A0A9P4UFQ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-fucosidase</fullName>
            <ecNumber evidence="2">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_440689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFQ0"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="7">
        <location>
            <begin position="53"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="366"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="491" mass="54720" checksum="390D7534290865C9" modified="2023-09-13" version="1">MWLACTVAAEIAPASYLRTPSARQLAWHQLEYYAFIHFGPNTFTNEEWGRSQSTPDVFNPTALDTDQWAKGFADAGMSGMILTAKHHDGMALWATNTTNYKIGNGKWAKDRIADGLSADVVRMAAASAQKYGIKFGIYLSPWDIHRDPAMPKPNLTGTIYDEPQIFGDNTTGDYNDLYARQLTELVTLKYDNGSQGPLFELWLDGASSSDTVQTFDWARFRDIIRENQPDAVMWGHQGVDARWVGNEDGYTLPTNWHTISRTQDQTHYEGEELQTGVRDGLYWTPAEADARIRDGWFWHANEKPKSADALMKMYMECVGQSVSLLLDVPPDTTGQIAKEDLEVLQQFKEQRDAFLKRPLLTPNLNVSASSVRGGDNTQFGPANVLDASAGTYWAMNDNETTGVLEIHLDNVYIIDAIILQEHIALGQRIGGYAVDAGVDGAYSRIVNGTSLGYKRIWNLTTSVEANEIRLQIFQANATPLINSVQALGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGV3</accession>
    <name>A0A9P4UGV3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_427737</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="11">
        <location>
            <begin position="903"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="373"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="659"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="842"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="983"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="604"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1071"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1111"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1149"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1172"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2449540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1998" mass="211272" checksum="870D33FAAC860129" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHH6</accession>
    <name>A0A9P4UHH6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="11">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galacturan 1,4-alpha-galacturonidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_346894</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="11"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHH6"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF14">
        <property type="entry name" value="EXOPOLYGALACTURONASE X-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040452416" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2452194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="442" mass="48591" checksum="A8D4867F19B26D1C" modified="2023-09-13" version="1">MRSFEQPLLAALFLLAHAVQGASLDENFLSTLRSPRPFHARAAPQRNRTCIAPSHGDSSVDDASSILLAIQDCNNGGHVIFAEKLTYTIASPLNLTSLNAVDLDIQGKLSFTDNITYWEKNSFDLIYQNATSFFALGGKDVHVYGAGEIQGNGQAWWDAYPGNKKMKRPVLFAVVGLEGGSVSQFKLRNAPFWHNIVMDSKNIAYSGLDLFSSSNNGNFEKNTDGWDIYRSDNIVIENSTITNGDDCVSFKPNSTNILVQNLYCNGTHGISVGSLGQYSERVDYVENILVRNITMENSSEGARIKVWPDAYSEKSESLTGGGGRGLVRNVTYDGMRLSNVDYGLTITQCYGQDDEEECFKHPSKLNITDVTFRNIRGRSNRVFSPIVGHLVCSSPHTCSGILAENVDIRTINGSNLVTCRNLDTRTLGGLNCTEWSKGYNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI80</accession>
    <name>A0A9P4UI80_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_5839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UI80"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="182" mass="20889" checksum="0E621E0633527CF5" modified="2023-09-13" version="1">MVVSVSSVFASTKGTWPGRKNVSISHGHWSFEMFRSRGVMNILTSSPFTILHMEMLIQFFILVTISTCCSKQYYLYLIIIHTRFLHVFCIPPSHFFSVDTATCHLASSQPHMYPCPPKKWLFEQSMKDRSSLIYCRHSIDATQPTPGSQRSKYPNKTNRASQNTSSWPVRSVRGNSHHDNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIM4</accession>
    <name>A0A9P4UIM4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADPH oxidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_349149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIM4"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:superoxide anion generation"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADPH oxidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
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    </dbReference>
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        <property type="entry name" value="Riboflavin synthase domain-like"/>
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    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="241"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="549" mass="63302" checksum="BCA9D2F4BD6D97BE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ17</accession>
    <name>A0A9P4UJ17_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_426213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2451745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="690"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2451745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1210" mass="132316" checksum="88A802AC6F5D7FFF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P563</accession>
    <name>A0A9P4P563_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_437691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P563"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="772" mass="81785" checksum="D6A44BF0F3588275" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5E3</accession>
    <name>A0A9P4P5E3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_449778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5E3"/>
    <dbReference type="OrthoDB" id="3797230at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="386" mass="42123" checksum="1E1F9B772E915EEC" modified="2023-09-13" version="1">MARSIRHKNDGVAPKARGAATTQTKWGRRKTTEQARKPAVKRVPRFVQKRASRSKAGIQNVGGRGQEADAEPAKLVDNTLPKDDKDREAWARKLYYALLNGPNLFPEAGATAWQVSRSTEKLFREGPSAAFLKANTAPAIVQQLKSVTFSQHFEDLVSFVEEQGVKSAVIACSAEELLMKVASAKKSTKAPTATELDANSELTRAMETTADCIDLTVELSEVDTDEDSSDEDSSDEDSSDDDRSDGDGSDGNGPDKDSSDEDSSYDDSSYDDSCAEADEAGSVGQGWENGDTMMLDYVSPREDAATALPIRTASRNAVIEHLAERSQRKGGAAVSSTSAAYKRTDARVPADQVTVDRASYFDPDPFWMVHLETMKNKRRSAVMRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5I1</accession>
    <name>A0A9P4P5I1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_491671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5I1"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF5">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="340" mass="37743" checksum="A45AB0FF28BC7BDB" modified="2023-09-13" version="1">MSTGSEELRQIRQPSVQETAAGAATSEKRKQQNRAAQKTYREKRKRKLQEFDELTSLPGPSNPHANASTSMSLVEPQSSTAFSPPEMDTSNITQNADWLFDFISPAAVDLTPPSSTSTTTTVTHRLAFPSLPTASQRALLAARVSAAYTRTRTQNPWAGFNPYANNLTISTLSFAACFFANALALGTTDHMYCTPYAQSSFYRAGITDSPYAETMLLAVQRSFDGLKPDLRPTPTQIVQSHHPAIDFFPFPNIRRRLIEGLAADPPALSEAEFWEDVRADGMVCWGGASAEVGGGGVPWDARSWEAKEWFLEKYVGVLGDEEDELWRASRWWREMRGEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5I9</accession>
    <name>A0A9P4P5I9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_173719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5I9"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="290"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="750"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="856"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="965"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2437821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="994" mass="107839" checksum="2413EAB0AA44B8F4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P626</accession>
    <name>A0A9P4P626_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Las1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_525624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P626"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="432" mass="48426" checksum="35F27F92A18ED97D" modified="2023-09-13" version="1" fragment="single">MAPQFVVTPWRDATELLTVRRDLFAADDDVARERAVNKIIAWRARKLELPLLLESTADIVEAKLRDGKHGVPSHALRLVYATAISRFVTGLLDTQTDLARLSLPSQSTPQFPVSLRETRHRIVHRHLPSLAELKRAANESLEWLWEHYWSHLDALLAPAASAQQLDEREVKERLQGVLKSYVKERKAEIKSRRKDARAADNAVGSWFGIGAAGSVKGKVLVHLLVAERNILPVAKKLGSSMEGAYLIWAPFVTALGTIDSMFLQTLTERMINVLSSPEHSMGRVEDDPAREGMCAWVVSMFGPAEQESREHSRRKLLDDVLGLCLMTPTFWTLKLAEELLKDGSVPGRKSWLAILEAAKEDIDEDDEDDEAHVLPPRPETSPDEMEVDDIESGLPVSESSSEAKQIRGPQKYLGLWRPRPIGWVPPGWSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P745</accession>
    <name>A0A9P4P745_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_167344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P745"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040454924" evidence="3">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="256" mass="28673" checksum="93EC08DAD9EA37F0" modified="2023-09-13" version="1">MEVGFTGVVFCALLLQGAKGDEKQGGAILHRALRRWGRVHAGKHSSALSLPVAEMNTWRCYTCLTSILLCDVWVLLPRLAQAREVSHLMSGFVHQGLSGLALGSRNHAQFTQFTQSTQLAHRPSLILQSSLALFPIGPSSLKLRSSRKPGDWSQRRKVQAPARPDMSPLKEPLHTKQHRLRNFQSLVELKKKKFGGLEGLRLRLRLRLYAWRLAYKAPCGSPAFVPLLDGTACRQSSWSVWVGFVTLCFAVLWIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8N7</accession>
    <name>A0A9P4P8N7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_504793</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8N7"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2438584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="248" mass="26742" checksum="0DF6BC3ACE5008A6" modified="2023-09-13" version="1">MGRQFFIGGNFKMNGSAKSVTEIIDNLNKAKIDENAEVVIAPPSLYLLLAREHLRKGIEVAAQNVFDKPNGAFTGEISAQQLKESGITWTLIGHSERRVILQEDDAFVASKTKAALDGGLGVILCCGESLEQREAGKTIEVVTNQLKAVADKVKDWSKIVIAYEPIWAIGTGKVATTEQAQEVHAAIREWLKKEVSSEAAEKTRILYGGSVTEKNSSELAKQADIDGFLVGGASLKPAFVDIINSNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9L6</accession>
    <name>A0A9P4P9L6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Retrograde regulation protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_368862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9L6"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF67">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="18"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="460" mass="50508" checksum="AA1A2D1301AFE8F2" modified="2023-09-13" version="1">MDEKKRRRRLLWKLDTHILPPLALLYLANFIDRSNVGNAKILGLATDLGLSNHQYATALSVFFVFYVVSELPSNLVLKRMTPKFWLPFLVFTTGVIVMCIGFVRTYGQFTALRALLGIFEGGLYPGSLLVLSSVYTREELALRVGIFYASASLSGAFGGLLARGLSSINTTSVVDGSWRWIFIIEGIITSGVAVGAYFFIPNSVDTAPFLTPDERAYAKQRLEASYQTSVLASGKAEQFQWSEVRRGLFSLQLFFTGTVYFSICCALFSFSLFLPSIIQSLGYTANEAQLLSVPPYAVASAVGVFTAFISDRLRVRGVISLFALPVAIVGYAAIARVESSVTKYGLTFLMASGVYGSVPPILVWILNNSAGHYKRATAGALQVCTANMGGIVAAFLYPNDEKPNYKKSHNIILGVLCYAWIGTALNVLHIWKINKDKAAGKYDKYIGYGDDREPSFKLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA74</accession>
    <name>A0A9P4PA74_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_476653</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1002"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1308"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="567"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="628"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1394"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1449"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1678"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1729"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="572"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1407"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1478"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1729"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1758"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1794"/>
            <end position="1811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2439473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1925" mass="216591" checksum="6F835836639B68A7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB26</accession>
    <name>A0A9P4PB26_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_367478</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB26"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="64"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2440642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="483" mass="53419" checksum="607CB61DB6FBF5D2" modified="2023-09-13" version="1">MSDAPFLTPEEEFAQLQKLSNEYEPEVTGPLVGDRQSSSAIATEYANADPVYRVKTQALPAKYAFFRTCRGDGHCGWRAIAFGYFEALLHVGDVAKFDVEEARLISMNNLLNLAGFSEDVYIDFAEEAYDLLRKLGGSLQLGNGPSLLLEAFNDMGVSMAIITYVKLLASAWIQSRAEEYQNYLQTDVKSYCSQNIEAAVCEIDDVAVAALSEALVKPAGIGLEILYLDRSIGDEVNAHAISQPMNFNGLLPMIRLLYRPGHYDILYKAEDLPAPPQQAPIHVALAYSNNHSFEAASPDANLLSMIPGMYSHNRFQTMDQSFGQRWAPATYDFDPTPAPQPQITPVQPYAPAPPAPVAPISVPHQDFMSPLHASPISHHSPGSHHSLQMEQQPVSLPFHSAPPPPVSIDRTPITVERGGPFRPSMYELEPGFGTGEVLPFQTNIFRNSHFNTCHFMNPSFQPEEWSPHEYRTGNKGKHKSVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBG3</accession>
    <name>A0A9P4PBG3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_488369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBG3"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2441939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="601" mass="67336" checksum="B62337C2458A2940" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCF5</accession>
    <name>A0A9P4PCF5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_364432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCF5"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="243"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="352"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="461"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2442450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="559" mass="61500" checksum="80BE5E236791A198" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCG2</accession>
    <name>A0A9P4PCG2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_104971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCG2"/>
    <dbReference type="OrthoDB" id="10352218at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="18367" checksum="988EB4B82ECDD2A9" modified="2023-09-13" version="1">MSASLHTRLQAASREDDEVTTKTIDLHGCQLEHTRISGISLGYTFINIILFNHSRLHTSTNIWYARSLLVFSSLPTQMPFGLYRCNWQSAIKRDRVTLFTSLLQQCLVRIEPSRSLFQRALDPRLNTDVTDILRKFKALEKATYRRLGHRCPNRITSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCL4</accession>
    <name>A0A9P4PCL4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_366512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCL4"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="8">
        <location>
            <begin position="149"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="400" mass="43249" checksum="E490B48FFBFB3C5D" modified="2023-09-13" version="1">MSAPKTIRWGILATGGIATTFTKDLLVDPATRGVRHLKHTVVAAASSSSAARAQDFLKATGAPADAKAYGSYQELVDDANVDIVYVATPHSHHYQNTMLALEAGKPVLCEKAFTVNAAQLRALADKAREKGLFLMEAVWTRYFPLSVYVRDQITAGRIGPVARVFADNSVASNPEVQWKDGSNRMVNPDLAGGALLDLGIYSLTWVFQTLYHTQPQEVRKPPKVLAAMKNYGPTKDADETTTIVLSFPRPADAGGDAHAIATTSIRVATSPAGNQDIPGIRIQGPDGEIQVFPPAFRPTRTRIILKDGTVEEKNWSQPGPGEGSGWHTGFGGSTNAEGEGHGMFWEADEAADALINGRKEGRYEGLDESILIMDVMDETRKQGGLKYPDKIETTKYPTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCN7</accession>
    <name>A0A9P4PCN7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_73065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCN7"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="332" mass="36852" checksum="2DC5540D610C6172" modified="2023-09-13" version="1">MALLSAEHLAGPGYIILNILRVINIITLSSVVASSIVMLVKTFIVSKFFFFDATSHVVTALAGMFLVVSECSLFRGYFARNWPLLSPSHGFVALGCSMTVLGLNMLGNMNKEATSQKSLGLPFWRLLLASGILAIVIGFFNVVASFVFRDKARHITARRVRSKGAITLTEEPPMDWETESKLKAFTISTHHTGTTSRTGTPPMRIGTPPVDMGSPQPASPEQNRFSQFDFNPLRAFRTARQSVLPSYHSGSPSKLPPFQAHRRRSSSLYSRSTSGQTKRSFWLKRTNRDSDVPHVPEISAPLNVNPQFAHLVKPNLAHHPSQRRFEADFDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCR9</accession>
    <name>A0A9P4PCR9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_71132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCR9"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000193">
        <property type="entry name" value="Ab-hydrolase associated lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="267"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2442629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="768" mass="86807" checksum="9D9C7CABD6F7F314" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD40</accession>
    <name>A0A9P4PD40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_393661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD40"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="613" mass="70573" checksum="8ACA5F86EBCBCBBF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDB9</accession>
    <name>A0A9P4PDB9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_456724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDB9"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="34"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2441777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="342" mass="39107" checksum="268A9FA4FD721D87" modified="2023-09-13" version="1">MATAYGAPQQSVYPESYVGFDSITKQIEKKLVKRGFQFNIICVGQTGLGKSTLINTIFASHLIDSKGRMQPEEPIRQTTEIQAVSHTIEENGVRLRLNIVDTPGYGDLINNERCWDPIVKYIKDQHSAYLRKELTAQRERYLQDTRIHCCLFFISPSGHGLKPIDIVVLKKLSEFVNVVPVIAKSDSLTLEERAEFKERIKEEFAFHNLRMYPYDNEEHDQEEVALNTSIKSIIPFAVVGSEKNIVVNGQQVRGRQNRWGFINVEDENHCEFVYLRNFLTRTHLQDLIETTSQIHYESFRAKQLLALKESSAVGGGHSSRPISPAADRELSRNSQRMTMNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDM0</accession>
    <name>A0A9P4PDM0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_433728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDM0"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="658" mass="71579" checksum="B9555C6A50C520E4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE20</accession>
    <name>A0A9P4PE20_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE20"/>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="365" mass="40521" checksum="75A285CCD5AF569B" modified="2023-09-13" version="1">MKTTNAKARAFQTPAPLSASAKTQKASPRLRRPKVKVQPDIQHAEEHDVPEVEYMPPKEFPLPDDMEDYLPRDWKIPKFENGGVDDVYHNPLEDDGRTKLQRQFEETLKRDIRKRDEEFDRVLDQQMERDHVDAARHFGVALPKKVVPKPTLSAAEPLRQRPTGPSTLKAKSAAAALSESRRPTYAAPAATIKSRLPSRQVADNKSITNSSAARHAAAAAASKSTIGYAQGRENAASRVQPRKPLSNVIKPAPFSITAKRTTTLPSTHNRNASTSSVNSKSRRAFSRSSSTSTNATLVAPPRDAPTYRTAEEIERELELMLLRDDDNDDEEAWANSFNSLLGGGDPFDEDVNDFQFQLPEDSEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEI1</accession>
    <name>A0A9P4PEI1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_69355</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEI1"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11774">
        <property type="entry name" value="SH3_Sla1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000256">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.700:FF:000001">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF19">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="393"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="132"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="460"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="709"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1089"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="773"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="809"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="862"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2442545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1163" mass="126223" checksum="1884CBA44AC985E9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PES1</accession>
    <name>A0A9P4PES1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_432888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040297444" evidence="2">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="184"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2443694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="347" mass="36341" checksum="D11E24129E0920D0" modified="2023-09-13" version="1">MRSCTSILLASALALAAVAKPLEKRVMVTEIDLEIVTVTKYVTAGQPAETPVSKEAITSSRNHGYQTPKASSTPAATSSQTPPKPSFPSSAGYSAVPIASSSSKSTPAPKPSTSSSAYVPAPVPSSSSPVYVPSPSSVYVKPSTSSAPHTSATPAPAPSAPSTPAYGVEHKPGDDQAYLASGVDYQDSMLWHHNRARANHGASNLEWSSDCESAASTAAAYCDFTHHVVDGQGQNLFTVSGDAYNATAGITESWYKAEADIYGAFGANPNMDTFHEWGHLSQVLWKKTTHVGCVTIDCGSKMTIDGAPSELSLYTVCNYSPPGNYEGEYAANVAPPINSYQGYSWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEX4</accession>
    <name>A0A9P4PEX4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_433170</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEX4"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009220">
        <property type="term" value="P:pyrimidine ribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000242">
        <property type="entry name" value="Dihydroorotate reductase PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="15">
        <location>
            <begin position="123"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="15">
        <location>
            <begin position="511"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2442755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="564" mass="60289" checksum="C687D61F7519E2AE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF22</accession>
    <name>A0A9P4PF22_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_48298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF22"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="150" mass="17192" checksum="86295121D1179F21" modified="2023-09-13" version="1">MQFLARKCPRVCFCGSLCCWWARVRVCTVEQQRQNMDRQRLITDEPHAPLGNNRGAKWQQGPIPRQGVFEASLAVSLIWSTSDKFLKALRRVVEQTLGLSCHEHERWRGRGVGWRHVSTVVRGLYSVGCQIQRMESSWQPVTSSYGQACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF99</accession>
    <name>A0A9P4PF99_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P171DRAFT_22680</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF99"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="80"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="260"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="429"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="481"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2443964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="519" mass="58019" checksum="76436B2534220A0D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFD9</accession>
    <name>A0A9P4PFD9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_432114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFD9"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58607" checksum="2DD9F2DAB69CA780" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG09</accession>
    <name>A0A9P4PG09_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_389472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG09"/>
    <dbReference type="OrthoDB" id="5278984at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="405" mass="44806" checksum="36CD96CD393AF61D" modified="2023-09-13" version="1">MAANMGFPADGEDDQGWKLYLTSLIMILSAGLCVVARVLTRVRIFELKADDYAIIASLAFSIFLSVAIQLAVVHGYGKHVRDLSTPELRTCLMFFWLAQTPYKVVVCLNKTSVMLLYMRIFIGKRFRHLCFAALTIVIGSGAATVFSTIFQCIPLERSWNKTVEGKCIDSAAFWVANAVINVSTDVIVLALPIHEVAKLQLKLRDKIMLHSVFLLGGFVTVTSILRITAVANSVHNLQDQTWGFIRRGVWTLIEANLGIICACLIVLRHPLARLCSKVFGTTKTGTSEGYRYGYSGGGATLGTTGSSKRDLRRASTRQHARLEDKYDCEDAHESFDERRRRVGTEDMWAGGDSFKMTAVAWCGAAETARKSDERYILPASATEEDFSQISIKSSGRGAGWAFDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHA9</accession>
    <name>A0A9P4PHA9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_432105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHA9"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2444015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="139" mass="15208" checksum="9E87ABF9E80D72E5" modified="2023-09-13" version="1">MSFRGTPRGGRGGGSRGGFTPRGGRGGFQPSFGPPDTVYPMGEFMHDVEGELMCTSVNEKIPYFNAPIYLENKTPVGKVDEILGPITSVYFTIKPSEGIQAKSFKKGDKFYIGGDKLLPLDKYVFFSLVVSCPVFALFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHJ8</accession>
    <name>A0A9P4PHJ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHJ8"/>
    <dbReference type="OrthoDB" id="3771763at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="214" mass="24603" checksum="594727A76ED0C5B5" modified="2023-09-13" version="1">MSQTTANTASQSEDIDGIETQLSRITMNAQDPVSQDPVEYMTTRAVSEATLAANWIRIFEHHHPTQMHVLDTYRESNQRIISFIRGYFAFSELNSFLQLDAIASDPHLGDFYDFLVDGESFATGPGVSVEYPDKTYASFEDWYSDPEKPQGWVFEKETQRLVPCIYWLTSNNARTQTREQDKHKENARSGDQDEEVKQHDADLSPQLEHMEIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIW9</accession>
    <name>A0A9P4PIW9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_484970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIW9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="109" mass="12050" checksum="11C6955A2426ADA1" modified="2023-09-13" version="1">MGHKNSKPEPPPQPPPPSQPWLPGNCPTLFECHPNSKRSEVIKHALVKAYKHNPGAARCLMCLLFLMVVVGIGITGWRVLSKRQARRKRMQAARVEAEKGGTDGFADDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJR8</accession>
    <name>A0A9P4PJR8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_473544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJR8"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2444468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1230" mass="139410" checksum="784853B8FDDA16C8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK16</accession>
    <name>A0A9P4PK16_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_512676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK16"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="1">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1113" mass="125190" checksum="B32CDFE9C5670C84" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM08</accession>
    <name>A0A9P4PM08_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carboxypeptidase</fullName>
            <ecNumber evidence="14">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_410639</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Extracellular serine carboxypeptidase that contributes to pathogenicity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="14"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM08"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040541758" description="Carboxypeptidase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="621"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2446427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="685" mass="75009" checksum="D7BEBF8544763DFA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM28</accession>
    <name>A0A9P4PM28_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate esterase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_512261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM28"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="77"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="329" mass="37862" checksum="D0E333CF754270B0" modified="2023-09-13" version="1">MSPAYTPHPEYDYPRDFQGYGEEGLNPKWPNNAKIAVSFVINYEEGGERSVMTGDGIAEQNLRENPLGGLRVNERNVSVESEYEYGSRAGFWRLFRLFNENKMKFTLYAVAQAVEENPSVVKRCVDVGHEIASHAYRWVDYHDFPVDKEKEYIKKCIESLKSLSGYAPKGWYYGRNSPHSRSLVPQVYQEMGEELIWTSDTYADDIPYWTDVNFEKDSASPKGQLMLPYSYDCNDFKFHVVGSGFRDPTGFYDHIKGAFDVLYEEGEKGMPKMMTIGLHCRIIGRPGRFAALKKFVEEIGKKEGVWVATRTEIAEAFRKEYPYRKGQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PME1</accession>
    <name>A0A9P4PME1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cip1-like core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PME1"/>
    <dbReference type="OrthoDB" id="5313668at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048955">
        <property type="entry name" value="Cip1-like_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21340">
        <property type="entry name" value="Polysacc_lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cip1-like core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="128" mass="13778" checksum="FBFF6BC0C4C72F96" modified="2023-09-13" version="1">MPDSAQGSKKHLRIGGQSKILMYNRESDDATLPDLSPNGIAASKALPTGSWQCFEYHLGADGSIETWLNGDAVAGLTTKNNANAAQWTRSSLKPKITGVYFGWESYGGDANTFWYDDIAIASTRVGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNB4</accession>
    <name>A0A9P4PNB4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNB4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040314182" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="52" mass="5485" checksum="947E0D32215442C2" modified="2023-09-13" version="1">MCTTVVLVSLLLRALASAVQSSFGLASYASGLRGRSSSDRADRYTIARAGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNZ9</accession>
    <name>A0A9P4PNZ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteinase inhibitor I78</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_452822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNZ9"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9022" checksum="41C645E4755CCA93" modified="2023-09-13" version="1">MPLVVPGIQSKGGEQIDEWTNKLMGKKIGDNHDEVTFAKKDLPSVHRVLQPDSMSTMDHRPDRLNVHVDEQGTVKNVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP28</accession>
    <name>A0A9P4PP28_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NRPS-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_453237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP28"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="564"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1078" mass="118929" checksum="DBCB08949F735247" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP58</accession>
    <name>A0A9P4PP58_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">POPLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_429765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP58"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="52"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="533"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="785"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="728"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="850" mass="94814" checksum="F7B9FD2A4F4BA87F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPB7</accession>
    <name>A0A9P4PPB7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_352724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPB7"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040357238" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="36"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="505" mass="54094" checksum="5AB3616F5A7BE3DD" modified="2023-09-13" version="1">MKSITTLSAAAALLSGTAEAFWRMECHSRSGLARIDPIVTPGKLSTHAHAIHGGGNFGMSATYDDLRASECTSCRATDDKSAYWTPALMFQHENGTTQVVRQVGGMLAYYLLLANEGEKIETFPKDFRMLAGDMNLRNFTGPVPDPEKSLWSESDKSQLLLGQKGIGMNCLNYGKDPEPSMYRHFLPDKQYLDDNCIDGIRAELFFPSCWNGENDSDNHRSHVAYPDLVNGGVCPEGFDKRIPSLFYETIWQTYEFKGLPGTFMFANGDPTGYGYHGDFQNGWSDEILGSAIQQCTNPSGQLSDCPVFELQTEEEGSKCQFKMPEELDADNCEGPAPGLCGNVPVQFGPEYATGLLKPGETGSATAAPTTVASSDLPAVPTLSYTTAQSAPAPATPTPEAPVPASSAAQAPAPETSVSAEAPAPTSPPADAPAPAPPAGNIVSTSIYTSAGTVYEVAIQQVEVTVTVSGPAPAENTLAVEQPSPAILPRAQLHRRHSHHMHRRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPL0</accession>
    <name>A0A9P4PPL0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_408364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPL0"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36508" checksum="30BD18D0B458E991" modified="2023-09-13" version="1">MLARGALCRLAADVPKTSTHDLPRISQLLRTSLFARHGASQPTVGAIARAFRATILEGRRAYATKSATEPTARVKREVKKAVATKKTAKTTTATTAKAKTSDPKKPKKTAAKKDAPKKRAKKVLTAEEKEAQTIRELKKKALLKDSPKRAHASAWQSFASEALKASKNIDDSQSLMKEAAVKFKNLTPAEREHYNQIAIQTSEARTAEYSRWILSHTPEEIVAANLARAALKRKLGRKTRHDKLVDERHNKAPKTTAYMIFTTQRLTSDEFRGIPAVERIKLVANEWKALSPSEKKASASPQAPYAQQLTTMQVFEDQYQAAKAAAAKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQZ4</accession>
    <name>A0A9P4PQZ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_508727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQZ4"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="598" mass="66387" checksum="CB80A43B8026A8EF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR13</accession>
    <name>A0A9P4PR13_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_518282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR13"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF57">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="370" mass="39922" checksum="BCA8CE140C3DECEC" modified="2023-09-13" version="1">MPVFPIKTHDQKAVLGVALSFSILAVLAVALRLTAHAIAHKPWTVSDYLIIVACTFAVGLQSNSITGVFQAGIGYGHVADIALEYGLEPITTLSQLIIPLQFLWVLSLSCTKASILFLYLKIFPIPWLVWCSYATMSIIVAWTIATILAGCLICRPFAYNWDKTIVGGYCGDQVTSFTVTGIINLITDAMVLLLPMYPLYQLQMATYKKVILITVFGLGIVTCVISALRISVLSTMDFADITYTIPKANIFSGLEPCLAVVLACIPMMRPLLGRSAATPLGSSKTRVNSGSQSTGPKVVGEDGFERLDDDTNRLWLRPIGLQHRANASALGDTMHGDIAGSQESLDGRRGLNSGGIKVKQSFEVSDRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR18</accession>
    <name>A0A9P4PR18_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_225101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR18"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="140" mass="15598" checksum="D1BB9E4738BC9FAF" modified="2023-09-13" version="1">MPCPYPQLAKMDPGFGIVIIIPVVLLAHILREIRRIRQIAEATHLGDQILGEPPPCPPPPFLTILSHGPRPSLGQIPQRPLRHPHFLNLRPAQLLHEPHHVHGRQQGRMGDAAEDAGRVQRHTRGVRGATGEAGYIYYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR20</accession>
    <name>A0A9P4PR20_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_350264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR20"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="277"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="339"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="850"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="950"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="852"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="883"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="971"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2449724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112122" checksum="CF146530D37877A3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR88</accession>
    <name>A0A9P4PR88_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_407569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR88"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000020">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="391"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2447431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="520" mass="57503" checksum="3CCD8A55C365B45E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRE9</accession>
    <name>A0A9P4PRE9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_482344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRE9"/>
    <dbReference type="OrthoDB" id="3799720at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040511734" evidence="1">
        <location>
            <begin position="21"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="672" mass="65290" checksum="E80FDF3CE615D32F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRJ4</accession>
    <name>A0A9P4PRJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_518336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRJ4"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="298" mass="32951" checksum="80C20051A8160578" modified="2023-09-13" version="1">MANVIKTVVSTGATSGLGFEAIKQLLAQSQSYHFILGTRDLQRAEKDFGDLSYDRQKHSLTFLPLQLSDLRTVKTFATQTLEKLGSSKIDLLLLNAAINKPADEPGVNGSKWCETYVVNSLSQHYLTHLLRERVTGRVVVTSSGAMQGVSGPARVELLDKELTANSGADSIRTYENTKFTQLLTTHWWRRELQGQAQVVAVSPGFIPGTALTRDAIEKLGKGIFPEAIMKSAKSVPEGAQSILAAYTRQDLPEDQRQIFLTSWGEWWATEVLEVSLDTALQDKWSASLAQIEREEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRQ2</accession>
    <name>A0A9P4PRQ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_354788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRQ2"/>
    <dbReference type="OrthoDB" id="5415072at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="129" mass="13251" checksum="8F0F54DC210AEEBB" modified="2023-09-13" version="1">MGNICGKSSKEDNFQGAGRTLDAAPAPTTKASIPTHVANAAGSSPKPKPKVTGPGRTVGGPGGSDGTNDPRAAAAAAAEARANKPVSGDLAKRLEEQKKQTRTQTLQQVANENRAQREADAATETRNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRV8</accession>
    <name>A0A9P4PRV8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_468584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRV8"/>
    <dbReference type="OrthoDB" id="3762808at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="347" mass="39977" checksum="ACC37CBEF0902D4B" modified="2023-09-13" version="1">MEDQHAEMKGDDPKTSTTEKHTQCSSCGNDASRACTACRVHVYCNAACQAADWKVHKRICAFEKILRDMMEDVCINKMPNDNVLYAQTEALWMSAPEWGCLVKANRAFMEGKLHCTPYHMGPIFPETKADLADFLFLHDYGIITTDSQAWMQEEVKQGSFWIQERQRPYVCLSFPTQHPKFSEDNAFRFVQALYKFAEKNSAVPVIIWNTYQHPQSAKFVRTKAQLLEWKTNIHDVQGWDFCPITQWRRGVTLEDLEMAEWEVETHLGLDPDDPGLIDAFCDGPDYRSSKRYPGSKSADPVAVSITTQSWDADWQDLMFVVEQAMKEADLRPVFRTRKMDSPDRLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSM3</accession>
    <name>A0A9P4PSM3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_428229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSM3"/>
    <dbReference type="OrthoDB" id="5400774at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39689" checksum="268C4A6878EC1A63" modified="2023-09-13" version="1">MPHTREASLNTRVSRFRDGYDHDESFATNEQFLRSRDSSPAATSPGRTSCFREHNESALGTTLFSANAMAHSDSDSDMDLSRPETHYDPHTNRDTAALLAPTIRVEKARGTSQERDDAPPSDEERLLAQARKHADAHVDAYVQQQRRKEAGQLPAPQLSSSRGVYVTRWLLRIVSCGVSIAIVAALLDTLNTHSKTKDVKQAFRNGDGGGIMNVWPELMKMHPTLLLLCVAATAAALSLLLSVASVNQRVRRMTKTGNIATITISAVCLALWIATTAYYASWDTEETHWDLMSWSCKHRAPDASYNHVNYGEICIEMRFAFWAAVGLAGLEFVNLMLFVVWYVKTRRARKYARLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSM9</accession>
    <name>A0A9P4PSM9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_353651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSM9"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF14">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="90"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2448618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="615" mass="68632" checksum="8A40515130BB9492" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSP2</accession>
    <name>A0A9P4PSP2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF159-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_351522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSP2"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="373" mass="41789" checksum="51A283CDC0C300D0" modified="2023-09-13" version="1">MCGRYALALRPSEVRQQLEQSQMPVDSAPDDDDVRQSYNFAPGYHGLVYRADGPEPRTSTSNNQHHEEQGKQDDSTSVPAAGHVDSTKYKLQAMKWGLVPVWTKRNPDYGSMLKTINCRDDSLYDDRGMWTSMKKKKRCIVVAQGFYEWLKKNNGKEKIPYFTKRKDGQLMCFAGLYDCVQFDDSEEKLYTYTVITTDSNKQLKFLHDRMPVILDNGSDAIKTWLDPDRKEWSTDLQSLLQPYDGELECYPVSKEVGKVGNNSPQFVVPVNSAANKSNIANFFGNQQKVAKVRKDEGIKRERSEAEDGGNTASGAPQQKRRIPAMAGPGSSQSPQKRGTKAAAKKATRSATSNGSAAKASPSKQRRIESFFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT03</accession>
    <name>A0A9P4PT03_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_351094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT03"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="6">
        <location>
            <begin position="54"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="364" mass="39947" checksum="AAC6775C618A03AB" modified="2023-09-13" version="1">MSLHFGKLGDWNWYWETLAPTIAQKTQAQHFFTKSASPRFLQSVGVFRGFPESDVPEIAFVGRSNVGKSSLLNAIVNADTKALLARTSATPGFTKTMNLYGLGPQGGVHYKKQPSGHGKIVGKGGITIVDMPGYGEGSLVEWGTEIMKYLQGRKQLRRVFVLIDAQHGIKDKDRSLLASLRLGGVSHQVILSKVDKIYLPEAKSIKRFDGKRLDKLRPKGTLQGLRQTMEKLREEIKPPVGAGAIGEILACSSDVLVDERRLGIDAVRFAMLQAINFPFRGDQSAVELAKKEGPKIRTMKTNTPPIAASPEKPLFRTVVPNIPEKPRPEPSAREQRAARRAGRKPSARGPSAMEMLERMSGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT47</accession>
    <name>A0A9P4PT47_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_198584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT47"/>
    <dbReference type="OrthoDB" id="3770722at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="231" mass="26611" checksum="FE57EA4461D0B1D7" modified="2023-09-13" version="1">MSDRSVSPFTVNPDFNPAAAPPAPAHVVHNPPVPLQIDDIDPENEYLNNLRNLFAPPIDMSNPFAQHTIHRHMPFTIASVLPRTAYKEEWEPKERRSDAYLAMQIQILTYLTTHAADELHPAQAHFFTENAGTKTHAPTAKQAVELCYFMRSHGFDTYVRLDPRGEKLRFYIADRDAGERRGQDSLYWQQDMKTGAVVPMEELARMGVRQRGRPWRRNALPYIFQDVETVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTC2</accession>
    <name>A0A9P4PTC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_353263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTC2"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="145" mass="15975" checksum="7605066B44511286" modified="2023-09-13" version="1">MADAKTFQSHINYQFHNCSLLEEAFLSAGASVSDTNVQGPKKGNKRLALVGDAALRLAVIDEWFKDDSDPAAGHQRFLTIGTNDRLKNIATNWEMEKFLVKNPCQQGECPKETLAATVEAILGAVWVDSDRNLEVVQNVLKKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU13</accession>
    <name>A0A9P4PU13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_427543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU13"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="131" mass="15199" checksum="03C61F13ECC5FA45" modified="2023-09-13" version="1">MMYRLTYKDDEEWTRFLAYFKRRTHKNLDESGDEDLILHIAWDVHEDPAMEGASSSQVRAHFRERVESLTTVRRFGDQLHESKGIDQWSGGIPRNMACLAINQVYVDRSIKDAELDDATASEKGFMMLVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVN2</accession>
    <name>A0A9P4PVN2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_479274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVN2"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="232"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="450"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="499" mass="54814" checksum="42E1CB57B6F7052B" modified="2023-09-13" version="1">MAKATDADTKTEPIRVGQRSEPRVGCRATNAPSSVDILFDATVPGIAKTHVSIRNRAPRHLKPEDLGTKEVPIPDPNSVPTTGVIRPYYFTISRSDVAPDGVHRAAILVNDRFPGPTIEADWGDIFEITIQNNITGPNEGTAIHWHGFLHKGAPNALGRHSHYSSQLIDGLWGPMVVRGYTTSYHASYEDNIRDQFSVPSNLVIAGINLINGKCLSSNLCDSRLTMFRSYNHTKVPEGTACQADAPIATFNFQPNKTHLLHLINTSGEGTQVCSIDYHVITIISNNFVPTEPYEADHVILGPGKRLDVVVTGTGGTNTYYYAHASVGPHDPVFHPNAVAVVYYPVADQTKPLFSDSAFSMNTSYCQNAGSKYTHSRRSYPPTCQQGALSKAVPAFAQNHPSQPEVTQEIRKGVKTNEPGHTILYMNNIPFRANYNYPILPLANARTTSYPDDPQWNVDHLRSNSSIRIILYNTASLFHPIHMQGHNIWVPAAGSGEEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX02</accession>
    <name>A0A9P4PX02_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_147895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX02"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="183" mass="20057" checksum="DB902FBC0B611AD2" modified="2023-09-13" version="1">MGCRKLICKILSANRHESCKILHFICPRSCAGFFSPAVCELSAQGYVYHRLALTLATHADGLAKPEKIHPQTGTDFSLSTAGFLGICSSAILCPYPFPRTVRDQSCTGHYCSRPGSQESDSSRSAEPSGGLVRVIRSVRATSNPLVDCRDSRRMKIECAMPSKPCLCEISETNYYFTDRIVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXB4</accession>
    <name>A0A9P4PXB4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_468351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXB4"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32813" checksum="3BDD30653E7539A0" modified="2023-09-13" version="1">MPQSNSKQPITGNGEQYYTIYVGKAPREAFAVDKDSEKLLRAASPFFAAKFDEQKRIIKLPSFDPETFRDYKDWLHTRRSNPRLQADSPERMKEWRPVCQAYVLGEHLKDYGYCNAMADVLAKYAGTSSEGSVKDLLACVENVFSRTARTSPIRNLLIDTIDGRILSTLPHAKLQSRLEALPQFTAGLFMRQKSKKIQSQWSDTCQYHHHKSGESCHADTETSIWTDIRNMFHDWSFFISTNAQGINDSYHAFQPCVSSTYTVLEKLREKCKAAFFWCKGFVKAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXE1</accession>
    <name>A0A9P4PXE1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_349903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXE1"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="271" mass="31577" checksum="43BB7A98F3FC6804" modified="2023-09-13" version="1">MSSMRNAVQRRNHKERAQPEERKKWGLLEKRKDYKLRAHDHKAKQARLKILKEKASERNPDEFSFGMMSSTVDKAGRKVTDRGNKSLDMDVVKLLKTQDAGYIRTMLQMVRNERLDLEKRLVLEDEEVRVLRDGENERKGMHTVYVGKKEEQDEFDDDEWFGKGAELPGRGAGKEPQVEDDDEEGAPKKQKRPSKKQQEAKELAQKQEQLFMSKRDRAQQRAAAHLEAVKARERALMAAEEELEMQRAKINHTVGGVNKNGVKFKIRERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXV5</accession>
    <name>A0A9P4PXV5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_400678</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXV5"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="45"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2451288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="314" mass="33117" checksum="CF7AD8BB7F31F37C" modified="2023-09-13" version="1">MAANTDRRRINAPSGGTSAPVFAKPVKEYGYLQSLRPNRTRGPDELRKTFLQTGVVPSASGSAYLEVPTTTTSSQPSLIPPTSSLKIAASIQGPKPLPRSAPFSPTLVLTTTVKFAPFATRYRRGYIRDSAERDLGVHLETALRGVIIGERWPKSGVEVVITILEGDEDTWWGDSKAEGGAGSGWGLLNVLAGCITVASAAIMDAGIDCVDMVAGGVAAITGDGQKVLDPCPAEHQDIVAACAVGYLASRDEITELWLKGEVGADPDTLIEGATHAAMGSVSVLREVLLENIETKTKAAKEGSKRKLEDVEMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PY62</accession>
    <name>A0A9P4PY62_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_439567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PY62"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2451034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="155" mass="17287" checksum="3622124B6841B273" modified="2023-09-13" version="1">MFDTINLSIASLPFTLLLSALPHWYTIYLATSQKVQGGWTNQNPRAFVARLNAKAASGKKLSDVEETILRGQAAQQNGFEWWGVWGVAVVFGYLMKEPKASMDYYTMVHVGARIAYNFLYLTTSRRRSSLLRTAAFQVGLYPAVAIMCRAAKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYV5</accession>
    <name>A0A9P4PYV5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scavenger mRNA decapping enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_425886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYV5"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000016">
        <property type="entry name" value="Scavenger mRNA decapping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="328" mass="36875" checksum="934FEBE49E294C97" modified="2023-09-13" version="1">MSSTTPPDVAARVEAYIPRFKLTRLLNQDQAGRRISLLGTIDDQDALLIAERAAFATDHAHLSTFPTSLTHIKNLGANDIYAWFLANSNPSSTTSPIPPDYKLNLIYPCTGKHIKKYSAQGLRIVTETPSIYTSYIRPWITSQREKGTLNWVFNIIEGRTEQEDVIYRERGPRDGFLLLPDLNWDRKTVGSLHLLGLVERRDIWSVRDLKKGDVPWLRHVRGKLVDATVGLYEGLERDQVKLYVHYQPTYHHFHIHIVHVQLEAGATQSVGKALGLDNIISTLENLAGGDDAGMQDVSLTYHLGEASELWEKVFGPLKEGRVPDVGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5N0</accession>
    <name>A0A9P4U5N0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_458839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5N0"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF25">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="168"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="323" mass="37368" checksum="11483A6485981639" modified="2023-09-13" version="1">MSSNSKPSEGFADKDGHFRRKDSAFRNHISSDPASAFPAESGRYALYIHKGCPWAHRTYITRVLKGLEDVIQLIVLDDSEKRDGKMLWYFSGENRDPLYGFKYLKELYEKSEPGYDGRYLVPTLWDKKSEKIVNNESSEIIRMMYTEFDAFIPEHLRESTKGAKGLYPPQLRSEIDAMNEWVYDTINNGVYKTGFATTQESYEANVYPLFKSLDRIEEHLSQPSHQPYLFGENLTEADIRLYPTLIRFDVAYYPVMGCNLKMIRHDYPHIHDWLRKLYWDEGEKTNGGAFKKTSHFEVYKANYAAARGVAIVPVGPVPDILPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6B1</accession>
    <name>A0A9P4U6B1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydantoin racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_371473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6B1"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12500:FF:000003">
        <property type="entry name" value="Hydantoin racemase (Dcg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26145" checksum="BDA8CD98466BBF8F" modified="2023-09-13" version="1">MRSILIIQPNSTKLMTDALRPLVDLLGFKDTAHDYFTAPSGPKSINDEDDAAESVKHCLPELEKVLSQHDGFLVACYSKHPLVPILKELKAVKFGRKAVTGIFEASVSTSLQIIHPDEKFGIVSTGKVWEKILSEAVVDFLGTGSDAGKRFAGVETTGLNATDLHDAPPEEVRKRMKDAVKRLLKKGNVGAICLGCAGMAGMDAMVREACVEELGEDDGNRVRIVDGVVAGVAWLEGAVRSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6E5</accession>
    <name>A0A9P4U6E5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_373041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6E5"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="50"/>
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            <end position="84"/>
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        <source>
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        <source>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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        </lineage>
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    <reference evidence="3" key="1">
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            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="77"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4U7Z9_9PLEO</name>
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        </recommendedName>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
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                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040424528" description="Ecp2 effector protein domain-containing protein" evidence="1">
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            <begin position="17"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20068" checksum="D5CB8A494394CA44" modified="2023-09-13" version="1">MYTILLLSSFLATALGTPLVARQNDTVWQPAEGTFATCDVTADKYISLVTGPEQGDVIFEHACAGILPDCAYPENLAEGTICTQTINYKLDGPKNKTLNALVEQKDNQNKLSEWAVNFAVTPVKQPEDSAGVFLTKADCIGYFQELLLKSDPEGCTIQGLGPSTGTLTVGGTTSLKDAVFGLSFVKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U818</accession>
    <name>A0A9P4U818_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SecE/sec61-gamma protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_435503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U818"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="69" mass="7613" checksum="D02399A7FF365E23" modified="2023-09-13" version="1">MDQVKELADVPQEFVKDGLQFVNRCTKPDKREFIKISQAVGVGFLIMGVIGYVVKLIHIPVNNILVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U852</accession>
    <name>A0A9P4U852_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_435316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U852"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="191" mass="21550" checksum="7EF73D4065C306FC" modified="2023-09-13" version="1">MSAPEPTPDEQKRLDAEAKANEDAEQAALPYKWSQTIKDLDVTVSIDAKYKGRDLDVKLTRNHLKVAIKGQDPIIDGDLPHPILVDDSTWTLETVPGGKEIAVHFEKVNQLEWWAHVVTTAPKIDTSKIQPENSNLGDLDGETRGMVEKMMFDQRQKEMGKPTSDEQKKLDILKQFQSQHPEMDFSNAKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8K2</accession>
    <name>A0A9P4U8K2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_421581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8K2"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000762">
        <property type="term" value="P:regulation of phenylpropanoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044595">
        <property type="entry name" value="KMD1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46407">
        <property type="entry name" value="OS02G0208700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46407:SF3">
        <property type="entry name" value="OS02G0208700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040336887" evidence="1">
        <location>
            <begin position="18"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="329" mass="35007" checksum="14FD865BAD079428" modified="2023-09-13" version="1">MHLLALFAPISASFVVSETWNPLPSIPIAPRQEHTTVFLPPNNVVVIGGITNGTQSTTSIVQSYSIAHRKWTSLPPLPIPLNHPNAAVISGTLYIFGGLAQTNTSWTAVSDSWRYDAKRKTWRPIADVPNGGIGSAAIGVWDGKIILAGGLQEILLVSPYTQSTVPNVHVYDTVTNTYLALPSAAAKLPDARDHACGAVIDRRFYVLGGRERGQLTGKSSVLVLDLDYLDKGWSVADGTMPSPRAGLACGVVEKRVYTFGGEGNLKVESGVWNSTEVYDVETDGWETLGEMKVPRHGGGAVAVGGKIYVPGGGDVIGMSPMSYVDVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9U1</accession>
    <name>A0A9P4U9U1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_523305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9U1"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF10">
        <property type="entry name" value="ELONGATION FACTOR EEF-1B GAMMA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="68"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2442505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="212" mass="23449" checksum="2CA915E57724C92E" modified="2023-09-13" version="1">MAPFGTLYTTVNFLHARVTKILAAANLNNLDIQIAPDLQYGITNHTAAYRAKFPHGKIPAFETPSGFHLAEGSAIAYYVAECGPRREQLLGRTPEDRALVQMYSKEDVEVHETQFVRCLRRLEEQLAGEGKVWLVRDDELSLADLSVASGLLWPLKMFMDAEFRAGFPRVMEWWGRLMAVEGVGKAFGAPVKLAGRRPAADGSEAEARRGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAL2</accession>
    <name>A0A9P4UAL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_65964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAL2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="100" mass="10977" checksum="E2FF740AEE76ED40" modified="2023-09-13" version="1">MVFQQATEYQHAAVALRQPIGRTPLAVVCGMPSSDKSTRAPQTPGPALSQQRNKQHGSLEVPHLSHLYHPEPPTVKPLAFVDGEPLTACQQRPDSPNMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAM2</accession>
    <name>A0A9P4UAM2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Antiviral helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_520788</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="328"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="606"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="528"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2444664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1286" mass="144262" checksum="D7076316A4136AD1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAQ5</accession>
    <name>A0A9P4UAQ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_433980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAQ5"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2442493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="292" mass="30804" checksum="8CB29F5847736C22" modified="2023-09-13" version="1">MATVQEVTSESAFQSEISSLPQSTVAVIYFHAPWAAPCKQMSVILSTLASTYPADAPIKFVALDAEELPEIAEQYDVSAVPFIVLQRGGQALETVSGSDAAKVRAAVEKYAGAGSGAAKTSLPPAQTVSKPPQTNGADTNGAKNLAGYAPNASDPNTAPEYSSGDAETSKEELNARLGELVKAAPVMLFMKGTPSAPQCGFSRQTVALLREKGIRYGFFNILADDEVRQGLKEYSEWPTFPQLYAEGELVGGLDIVREEFENDPEFLKEHSVTGQKGGPGAASAQTQAPIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAS4</accession>
    <name>A0A9P4UAS4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_434031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAS4"/>
    <dbReference type="OrthoDB" id="5419542at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2442553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="357" mass="40218" checksum="AE360552BB393237" modified="2023-09-13" version="1">MADHFRPSLLYTAPSRVSSEAPPQRQKDSTKRKHHLHRHHHRHHSSRHHAKEIVQSAFPSQPPTSFGDLLKQAKESITSSPADSRRASVAVTDGAADKAGQTDGTGGLDVPPLRRPGRPEDLVREQRRVELREDALRSSLQNLSDQSLKTSRRLDDTYYSLLERIATCRQTIGSLQELSNLTNELHHNFETDTQELAEDVEGQFKGSDNFETHQEQVSALELRIKAGKEKAEALEGRLAEARNRVNKRMKLEAELEVRNTRHVRILWGVVGALLGLVLLSILFQQLRPVHPDTGHTRALDFASREQILNAPIPDIAKEAIMRPNQAKEQLDVRIESPSARASAALPEDDRLRVFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAU6</accession>
    <name>A0A9P4UAU6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_364160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAU6"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="330" mass="36521" checksum="98BB4E5D4D9A49D0" modified="2023-09-13" version="1">MALQQFPDKSKSFKTSDGTTYAYVVVAAKDPSKATFLLLHGFPSSSYDWRHQINSLTQLGHGVIAPDLLGYGGTDSPAELERYKFKTQAGHIAEILKEEGVPPVIGVSHDWGSGLLSRVYNYYPELLKGLVFLSVPYMEPGQFSLDAINGLTEQLFGYPVFGYWLFFNRDDAADIGNRNNASFTSLLYPSTPEVQREHLCPYGAAEAWISSGKQSDPPSWLSEAEVATHNKIIGDKGYSGPLSWYKVTIRGLNDEDEAAIPDDRKKVSLPTVFVNSDQDPITRVEVAGQIAQSGKLTDVKLELVQGSGHWIQLEKKDELLKILKTFAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB30</accession>
    <name>A0A9P4UB30_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein-like protein L2/L8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_390854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB30"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="5">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2442898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="254" mass="27416" checksum="FC98F1261C8AF6E1" modified="2023-09-13" version="1">MGRVIRNQRKGRGSIFTANTRLNKAPAQFRTLDYAERNGYIRGVVKEIVHDSGRGAPLAKVVFRNPYKFKHDTQTFIANEGMYTGQFIYAGKHAALTVGNVLPLYSVPEGTVLTNVEEKAADRGALGRTSGNYVTVIGHNPDDGKTRVKLPSGAKKVLSSQCRGMVGIVAGGGRTDKPLLKASRAKHKFAAKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISREAAQGQKAGLIAARRTGLLRGTQKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBB8</accession>
    <name>A0A9P4UBB8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_53231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBB8"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41481" checksum="F338AC6EDD9035BB" modified="2023-09-13" version="1">MYEKETSAAWLCLPRHLDTTPAVEDSESEQEEHTAYPFDGHPSAAVSGHDANDNSSSQKLHRKALTQLVVVRMYKSPAALRNESDTLSIVNDSEGSEDFVGASVLRELHSGIPTDSWLCLRPIFGKNLEAFGQACLATNRIPTYFVWHIVLRLVSALEFVHTAGIVHGDLGSANVMLRCSLPGREDRDWPDVVLTGFEVEVDMDLYEDERREDVRRMSEILYTDVICRWSDAGTLIPFLNLTISQPDQLMQFAAALKTMVEAPLGEEVPSLSNFKVWKAVAVAEMAKGPGTCPAWIKIAAYDALVTEKELEKAMRPPLVLNFGPDSEKFKRWVRARRTPVALRKKGTRGNRIGLLVVKFKIRRERFANLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBQ3</accession>
    <name>A0A9P4UBQ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_520577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBQ3"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="102"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="196"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2445849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="304" mass="33193" checksum="60D2420739DE4E70" modified="2023-09-13" version="1">MSADFWAGYTSGAVGILIGNPLDLVKTRLQAGNAAPQTEPTGAVIGPARAAPQSFRQHFDRAGTLVKGTTAPLLGYGALNAILFMTYNRTLTFFNDSPELPTSLAKVWCAGAAGGLASFVVSAPTELIKCRAQVSTDHATSSWTIVRDVWKREGIRGLYYGGGITSIRDAYGYGWFFWTYEWSKQAVSSPTDTDRETAIKVLLCGGLAGVVTWASIFPLDVVKTRVQTQLINAPLYREGERETLLQHQAHGKRLSTLQVAQKAYQAEGAGVFFRGLGICSIRAFVVNAVQWAVYEWMMRLLRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBZ4</accession>
    <name>A0A9P4UBZ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_280963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBZ4"/>
    <dbReference type="OrthoDB" id="5295250at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="418" mass="47433" checksum="4CAEA36F7DD255AA" modified="2023-09-13" version="1">MATPPAFIDAFRALHTSTARAAAIAALADELSPYEWRQLQALVGAKSFHLDIVGTLPAELVFHIFSYLDISTPVRLQTVSRRWCDLLRSSELLKPALRAWYDNTVALEDASYADCLQRAQSIQRFRTGRCVQVAASKPTLEPSKRIALSEDFLVDVPHPFRQVRITNLRTGEDRRVGTEGRDMIEKFIASSELIACWNQAQTCYIFDYSATQRAKLRLPPSMNTFRACRGQTFICGGILNQHIELYLWDAQSQKGKTVRLNQPPFDSAITSPQCLDVQILPNPRSKTFTLFCTKTCEARWCGHHVSNMSIDYYAITFDGQLVQQNTFMIPLPAETTEFAGASITSIHPVDRNGGHRISVFCRYNHNGFTHMLHFDETLQTFSLPKQPTDSAEDVRTAWWKDSFYQIFWAGLQENFTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCK8</accession>
    <name>A0A9P4UCK8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_389251</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCK8"/>
    <dbReference type="OrthoDB" id="263957at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17487">
        <property type="entry name" value="MFS_MFSD5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040248546" description="Molybdate-anion transporter" evidence="14">
        <location>
            <begin position="23"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2444473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="462" mass="50961" checksum="4FEFF1190E7ED641" modified="2023-09-13" version="1">MDLYRSTFVGLLLLNSVVFVRSYRSKTGSFSETPSNSEKVEHRGREDDDAERIRQLKWKFLPVFLLVNGADWLQGPYIYPIYKDEKGLPESMVALLFMVGFLSGGISASFAGTFADRFGRKAGCLAYCVIYSCSCLTLLTDRIEVLFLGRILGGISGTLLYSVFESWLVAEYNKLMIADEGSALSGIFSMMTTLNSFVAIVAGILAGWLVDHVGTAKAPFMASLGCMSIAFIAISKTWSENYGSRREDTAEATSLLAEEAKEDYVQVPATSALKLILADKNILTLALTSCFFEGTLFLFIFFKFPALKLCHELSGSTTDLPFGLIFAILMCCMMFGSMLYNNVSTSASSLPRKQILIYTLVAASLCFFVPAHVREENVVLWCFCVFEVCCGIYYPSMGSLKSKLIEDGMRASVYTILRVPLNAFVVLALSMTQEGEHHRSMMFTLCSGLLLAAALAVYRILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD18</accession>
    <name>A0A9P4UD18_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_250514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD18"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000046">
        <property type="entry name" value="Nudix/MutT family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2447349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="160" mass="18295" checksum="009B2B3C58685E83" modified="2023-09-13" version="1">MAAAQQLPMQSRTGRTNQRYGSQGERLVAGIVPLSSDKHYVLLIQSTRRGGWVLPKGGWETDEATAQDAAKREAWEEAGIIVKVTYDLGLIAERRRPDQLTAQAPKASYHFFEATVEKQEAQWPEMHKRSRQWFTYQQARQALGDRPELLDALDRCTMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD51</accession>
    <name>A0A9P4UD51_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-2-hydroxy-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_485100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD51"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF140">
        <property type="entry name" value="FMN HYDROXY ACID DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040266497" evidence="6">
        <location>
            <begin position="17"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="7">
        <location>
            <begin position="44"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="314"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="337"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="397" mass="44096" checksum="A1E9B08E72AB50DC" modified="2023-09-13" version="1">MRSALFFSGLAATALAAEPFLNEPDTGLETFLQQSNNWTEGTLPALKDIRGFNDFDFAARQKLSTENYFYYRTGSAGEWSYRNNLDIWKKVKFRPRFLRDTTKVNETLGVTILGYNFTSPVFIAPAPRAQYCNERGELNYVEASADEDTLYIAAMYAKKTIEEIAAAKSNNTINGPQVIFQQIYTNANLSVTWDNIARAERTGAKAIVWTIDAPADAVRHRAARFDTTNANSATSALTWDLYDQMKNRTSLPIIPKGIASVEDAQEAIRRGVKAIYISNHGGRQLDHSPPPLEIAYEIYRNAPEVFTQVEVLADSGVRYGTDVLKLMALGVKAVGLGRPFLYSNCYGREGVKKAIQMMKKEIVLDAAQVGIADVRKIGPSVINARELEETVYIGTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEW3</accession>
    <name>A0A9P4UEW3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_429159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEW3"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="105"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2447530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="603" mass="64695" checksum="065CED872BCCAAF7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEW6</accession>
    <name>A0A9P4UEW6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-carboxymuconate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_319808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEW6"/>
    <dbReference type="OrthoDB" id="10006285at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="37839" checksum="A1526856EA5A1335" modified="2023-09-13" version="1" fragment="single">GKAIYFITNEAENAVVALPIKSDGSLAAGRSTKTGGAGAVMIQAASGNPQLPDGLASQSSLTVVGNNIFAVNAGSNTVTMLAIDPRDPLCLTTVGQPIAVPGEFPNTVAASAKNNLVCVATTGAVAGVSCASFSHHGIGPMDKLRPFDIGQSTPPKGPLNTVSQTLFSGDETKLLTLVKGDPPNNKTGYISVFDVQHERRRPSTLATQGVRSSPNSTAVLFGTSRIPGRPHSFFATDASFGAAIIAVHRNGEATTSHNQTIDGQRATCWSTISTSTGSAFVTDVARDLIVEMDVNDASIIREYDLSANRDPGLIDLASGGNFVYALSPGNATTDAAITVLDVSDGKGAGKQTQRFSLAGFASSAGQGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEY3</accession>
    <name>A0A9P4UEY3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore assembly and biogenesis-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_441830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEY3"/>
    <dbReference type="OrthoDB" id="3559694at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17935" checksum="A449D23044134C23" modified="2023-09-13" version="1">MDVIQNYLSLLHTLLPSTLTNPLISAITTLYGLTKTLQTHFAPLVTQVITQPDIASVLALLAILWFSLQIFGMLYRSVMFWVKLVWQLVKYCVIIGLSLWIWNRGVDGAVKDAQELVGFWMGEYEKFRGEAKAWKGAEEAQIRMQAKQRAAGGGGFGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEZ3</accession>
    <name>A0A9P4UEZ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_471113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEZ3"/>
    <dbReference type="OrthoDB" id="5374569at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="413" mass="46129" checksum="38F2D2FBD31C83AF" modified="2023-09-13" version="1">MPPRRQLPWAIKDGGKKTVVKPRAAKRAVQSDIDDDFFDGTVLESSRKGKERANGAEPDEELPGLSSRFAPTTRKGRETSRGDRLPSSSPPPIDADLPPPTTEFMLTGVDKFDLRDDEWMMVEDELLQTAKLFTQHLHLAEYEALKRKMEELRKETAARPVVPNAIPSVEGHFKRKAQEQAKKQKKALREVISTRDNDSEGDEEPRRAVQDRSAPSFPPARPLSTARAPATSKPLQTSGDVSHETASDSDDLDAPKRPPMKKPSPVKRPEVFAKPALPSKTPSKPARGQRRNLWDDWDELTANPKPSIAAPSPSRTPYQVSSPTNPVGLSANQQLSSPTTSFHTAVTQRIDNATPMPTKRRTTTFDDDNANTPKRGHLDKETADRLAKRKADKDREEKTKKKQKYDDIPTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF81</accession>
    <name>A0A9P4UF81_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetylglutamate kinase</fullName>
            <ecNumber evidence="6">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">P171DRAFT_519296</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="6"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF81"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000046">
        <property type="entry name" value="N-acetylglutamate kinase / N-acetylglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 19" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 19 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17 19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 19" id="KW-0521">NADP</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="21">
        <location>
            <begin position="341"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF2446962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="894" mass="98787" checksum="8DA26655D0DE8EF3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG65</accession>
    <name>A0A9P4UG65_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_380766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG65"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="428" mass="45984" checksum="4E2BDE041D3B9CC9" modified="2023-09-13" version="1">MAGDSQNPLVSNTRASDTSPTVQLHPLVLLTITDCITRHTLRQQEGPIVGAILGQQNGHEVTMEVAFQAKLVSNEHGEVVLDDEWFMKRLDDYKDVHKQPQLDIVAWFTLAPLTGPTPQILPIHNRISELTDSPILCLFHPSDAYSEATTAGKLPLTLYETVYESAAGGPNDKAMDIDGAVQNKALKFRELVYTVETGEAEMIAVDFVARGGGNATAVEGSSAASKGKAGKAVEEKDKKAKGKQKESPKEETIDESAVLTAEDEELLSTLTAKINAIRMLGRRISLLRTYLASLPPSYLSDPSLTLDPTPSNDHPLPLNHSILRSVSAMLARINILAPPDVEAFTLESQQEASDVQLVQLLSSITNSVSAARDLGKKSQIVESGKSQSRRGAGGMGSIMGGGYEGGGQYFDTIMGGGTSRQFSADRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGH2</accession>
    <name>A0A9P4UGH2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_440068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGH2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="292" mass="31526" checksum="3158A55CA2BB3441" modified="2023-09-13" version="1">MLPLAIAVQHRALRVGCRGVLAEGEGDGGLSFAPLQAGDGRECFAQQRQIDPCRSVPPPLFWHRGAYRPEARGGLPVARGGDAASDCRFCPVPARKRRHAPRLTTNTNSQLQSGRGTGIVRERDRGGSVARAPCQASAWARYSKLRNPTGDAREHFTAARRAAPPSSAHLAATPPSGSVNGEPDLRLGHRTIAETPVQERPQTSSEKPTKPHLQHLLLWSSPPSPSPSPTPDRRLPRARDLLCARRACRGASPSNHRYWLLAHGLPPSLSILLTTAVPTPTEEATQSTMPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGW6</accession>
    <name>A0A9P4UGW6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_507876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGW6"/>
    <dbReference type="OrthoDB" id="3788444at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="59247" checksum="7186ECAD8A1D00C7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH23</accession>
    <name>A0A9P4UH23_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_426201</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH23"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2451729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="239" mass="26840" checksum="B208491B2E59EDC8" modified="2023-09-13" version="1">MKTKLKGAQIGHDLLKRKSEALTKRFPEITRRIDEAKRKMGRVMQVAAFSLAEVTYAVGGDIGYQVQESAKQARFRVRTKQENVSGVILPQFESYTSDSANDFALTGLGKGGQQVQRSRETYARAVETLVELASLQTAFVILDEVIKVVNRRVNAIEHVIIPKTENTIKYINSELDEVDREEFYRLKKVSGKKQRDAAEADAEREASKKDAEAEERDNAGAEADTQDLLGDQENEDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHE4</accession>
    <name>A0A9P4UHE4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_428210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHE4"/>
    <dbReference type="OrthoDB" id="5369447at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2450125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="294" mass="32363" checksum="5E4D497287B95E3A" modified="2023-09-13" version="1">MENFSASAKQLIDLCEYGPYEQLVSVLQDTLVMKTVLSTEVLQPNPYSNSTEDFLILERMLEAAVRGEQFDHIAALLELGRQYGIAVPYLVTARVVLAAINRPESTLDLFHALERAHSDVWAITLPMGGQVIDGAWISARLFPQARLSLLRHLLARGIDPEQLVGRMVFARHSLLFQMVFWGAPCEMFECLLEHGVVIARSRAQHAAARRGRIDVLEVLLRHGANLDERFGKSALFPDGTALHAAAAAGTMSAVKWLVANGADTTLRNCDGATPGDLLPVDCNDDIAQLLHCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIQ1</accession>
    <name>A0A9P4UIQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_478991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIQ1"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="347" mass="38841" checksum="AC01E559B3458A74" modified="2023-09-13" version="1">MSDNVEMLQTLRDSGFFPNLNQTTQEGSVESVKWLIDNHVDINPLTRTCRSTPLHFAMASGMTANVLTLIEAKAQFLQKAEGKTPELVVHPKSKSGLVELLPYCEIHCHYENAITRRELARTRNRSWIDQQNLYRIGNDRLESVKTLLQHGANPNARDVLGRTPLRLAARASTTDCSKPLIAHGAKIRSQDVFLNTPFMEACKSSESNAMLLMNLKVNTYMINKWGQSALYLVSDVRLLSQLHDVGWDAHLKDAFSNTPANIAAWNFPQLATYIRSSTLHAIHVEELPNLVKPAYYGFYKSSKNLHGTDGGVFSLSTAAALGDIKKWRFFFKLAPTVNILNDAAVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIX9</accession>
    <name>A0A9P4UIX9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_427323</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIX9"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="405"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2451103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="769" mass="88934" checksum="FE789A7D29EBBE1F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ76</accession>
    <name>A0A9P4UJ76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_401747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ76"/>
    <dbReference type="OrthoDB" id="3913483at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="109" mass="11010" checksum="FF8C7390B70C6AA9" modified="2023-09-13" version="1">MASKQEIIDERKAALPLPEDPPVASDFNSADARTVNVGSGGQASDLSHSGLGGETLRSPATTDAVGSTGRQAKDGLDGIPNDAVTRDAKDKAGLAQTTGKDYGTPSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJC1</accession>
    <name>A0A9P4UJC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_478233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJC1"/>
    <dbReference type="OrthoDB" id="10556001at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="278" mass="31016" checksum="C200EC5514081CE7" modified="2023-09-13" version="1">MAAALSLEAQQLLDTLSTAFPTSTGIDQSAALSEIESNSIVDEFWAGPWDAVVPVGFPNPDFQKANKAPFLRMHGCHIVDESDCPRQTMVGFVAEWGHGILTLIHPEGDDMTHNATYNVINTPDEYSRMQLTGIFAPLILADRARDISAWILDPASVRRGWRCLAIFIEYVFLTQNVPSLLLNWGIQEKSTRLREAFERVANGREMQRPIQGQESFLKKRKWSDATNENSNSKQRISKMSGLDAVQVKKRSGGKPHLLVMVPVPPAQLAQVTRITHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4S6</accession>
    <name>A0A9P4P4S6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_423509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4S6"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="49"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="628" mass="68280" checksum="5D800D4473813F0F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5L9</accession>
    <name>A0A9P4P5L9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_437373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5L9"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="148" mass="15827" checksum="DDAA239839FB8A15" modified="2023-09-13" version="1">MAQTAPSPPELTLIYSMQALLGDRFSLGPIPNGQERIVIPIVGGTFKGPKLSGKVLNLGADWRLTDANSAIRPDARYNIQTDDGTHIFVQTTGLPPGKDGRTMLRGQFETATNGMYAWLNDVAAVGVLTRSGTSSVTIDMWEATPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6A6</accession>
    <name>A0A9P4P6A6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">magnesium chelatase</fullName>
            <ecNumber evidence="1">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_370877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6A6"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF132">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChlI/MoxR AAA lid" evidence="3">
        <location>
            <begin position="274"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="369" mass="40355" checksum="F68770C71FC5C5A8" modified="2023-09-13" version="1">MDDSGDRIADKVQALSDIELAALLCLITDQHCIIEGEKQSLDELDQEIRLVATNVFGLTWAVLECSESTTVDEFGAGILVDETAGDYFSLANESTREEYAARAGSPKKFNGRVPRSARPFTPLGSRKIASVVIAKNLNLASNQVQVQALELIRGKRNFTRTAVHAAPKPFLFIALNAAGTASLSLHLNDQLFISHTHQLGDGFPNLEELQEKKPIYEDDASTSSVVRFPPEAIEKREGTIMFTEADLNELSTLTAKVSTSTEVRAYLHNIVIFMRQHRAVGGGISAMATRHFDVLSRALAPLHGLSYITPALVALAARKIYPHRIQITSPENERSLQWGSSLDAVRAVLEGVTPDDVVEEVLQSVEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6U3</accession>
    <name>A0A9P4P6U3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_491773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6U3"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="425" mass="47971" checksum="C22AA719D065606A" modified="2023-09-13" version="1">MHHFATPLRPAQQTNLSRNRNHDGASPQDKSPDDATDHPQPDVQSAPLYNRWEREQRRVAGLSADDAFPVPAPPFPHAPLREPRPKFTSARVQQELAGLSPALYAHAASSKDGSVASKAVTPALRTSHLNVLTTVMHRCLLEGDYQRASRAWGMILRTQAHGTRIEPRYNGLWGLGAELLLRRKSGDAIFGEGEQDGPLSDDYLYSEEGFQLAKDYYERLILQYPVRNFQPHAIDATTFYPPLFSVWIMQVLERSRRTRRQLKRAVRRSFDASMALDADDTTTPEGKRTQEARIQHEELAGAREICRRLEELVQSPPYDKSAQLLVLRGHVGLWVSDLLLGKTVTLEPDDESDYGSDSDEQDVEVDPTEMSTKRAEGVQQVKEAKTFFEQAIKLEKEASDSSAFNLEKELRDITKRLAELGNPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P737</accession>
    <name>A0A9P4P737_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_162851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P737"/>
    <dbReference type="OrthoDB" id="10538676at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="98" mass="11057" checksum="1FB6293BACFDAC1B" modified="2023-09-13" version="1">MGRLLFNACGSKCLSMPRGSCSLGTRKMLLTLLVTCSPLRVYLQSTRCGEHFAETSRRVGQDVWGSAWHHLTRHHAVSSCSRLCSQHEWGAFGKQRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7N5</accession>
    <name>A0A9P4P7N5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_369118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7N5"/>
    <dbReference type="OrthoDB" id="3761576at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2439929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="398" mass="45011" checksum="8B3C8320FDCDCCFE" modified="2023-09-13" version="1">MGSFFNIDPWFFASYVHQAWRKTSSQSPNNCSLPSRDKKQNFLSLQYHRIVTFDQKDTEMKSLTLNRNQPRKAVILPTMRGERIGLIQHGCSVLKVDGPGDEWTGIVLLDAPISHNYTASKNHGFSPTYLASNPFFGGCEDFATSPAASIHGLTYNPATVSNRGMLDELVHYWTQETPQIFTASKPTLRAISYYPLKIVAAEWVNYIAVMGMSVREYELSTTFSGDLIAQLEKLNTNLRILQGWRRRVLSTQAKLRRTIRFIENHVDHKHPSEDWDVLVEDFEFIRTGVAEHGERLEAMVSVVTSTAALIEGRRSLTEKENVTRLTILAVVFLPLSYIESLFSMLDDFRPGGPHFWVYFAIAVPMAFMVGLIAKPPVSTVKNMVGRIGEKIAALVRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7S7</accession>
    <name>A0A9P4P7S7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_490863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7S7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="345" mass="38226" checksum="5C94FDEFD6135965" modified="2023-09-13" version="1">MRNTHHRHLLEPKVPQGNNLELVGINIEVNSTKIILDELVGNVEVEGPVSNPSSSLNVWAYLKDPQELKDPPGHDLELMDVSIEVGVPPNHVGVFPNHVNIKVEGPPRPHGDLELMVPAEVCWAGEPGKPALFVVPRDPMGSRAVPEDTSRYLELVDVDIDEEVPAAPFFYLSSPSSDLTDHSLIVLQDILVSHVWAHIRFAPYLLINSVRLPYGEAQAFVRLRFTGHIRGDGRRVSGLRVYVPGLVDVSIGGEVPTPMGSSNRHPVLCSFAFPDRHHLLLSVRFIFALTFIQRWSICADTLTVPAGVIFIAKHGNELVDFSIEVEVHEPRVGYSRHSAPWMILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7S9</accession>
    <name>A0A9P4P7S9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein-like protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_421332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7S9"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2439990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="151" mass="16866" checksum="FEA240D32D69F4D1" modified="2023-09-13" version="1">MGGVSVKDVDAQKFISAYAAFLKRQGKLPMSTGWVDTVKTGHSKELPPQDIDWYYVRAAAVARHVYMRKTVGVGRLRKLHGSTKNRGSRPSHHVDASGSVDRKVFQSLEKIGVLEQDEDKGGRRITQAGQRDLDRIAQTTLEAEEEDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7V9</accession>
    <name>A0A9P4P7V9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_448538</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7V9"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2439020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="780" mass="83245" checksum="855DA7C42A5F6D73" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P898</accession>
    <name>A0A9P4P898_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="13" type="ORF">P171DRAFT_394550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P898"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="174"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="395"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="395"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="434"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2440260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="573" mass="64094" checksum="AD5F7878B16B2B6B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8E1</accession>
    <name>A0A9P4P8E1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_397864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8E1"/>
    <dbReference type="OrthoDB" id="3141857at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039965">
        <property type="entry name" value="C3H7.08c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="152" mass="16319" checksum="C3B4662361E50440" modified="2023-09-13" version="1">MSSIVGRTALRAAPRLRTPQLPRRWNSSVSSDASTAGQNDRQAGKDALKAGAKRDPELYVLLAIMSGIFGVAGWHFSRSPTSASSERSVSQAPNSKPWEEGGGEGKYQYHPGGDTSAPKKDAPSALNVVIIPNVTLPKELHEAYNKWGKDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8X9</accession>
    <name>A0A9P4P8X9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_122106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8X9"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="227"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="655" mass="74040" checksum="7449B837C9D6B83C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA76</accession>
    <name>A0A9P4PA76_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_419523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA76"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2441279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="220" mass="24252" checksum="7778A0EE47F695A1" modified="2023-09-13" version="1">MSDTDMDGGIALKAAGAMDTTSPLEAAMSMTDSTLATRRPVTVDKPTPYTFDLGNLLANDPNPVARDADEEALAANARDAAQVLVNQLLSTCEIKSSADGVHLVLPPCTTPLPREKPIPAEKPPTKWELFAKKKGITKNKNDKTKLVYDEATGEWVPRWGYKGKNKEGDNEWLVEVDDKREKETGEAHDARADGRAARKEKIRRNERKQRANERNAKKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAK8</accession>
    <name>A0A9P4PAK8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_475002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAK8"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="283"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2441474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="543" mass="59599" checksum="0D3A8030839E3EFB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAN7</accession>
    <name>A0A9P4PAN7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_394849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAN7"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="367"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1188" mass="134682" checksum="9206534909D646B7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB62</accession>
    <name>A0A9P4PB62_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhamnogalacturonate lyase</fullName>
            <ecNumber evidence="11">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_489322</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="11"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB62"/>
    <dbReference type="OrthoDB" id="114708at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000102">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000020">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011794">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040556997" description="Rhamnogalacturonate lyase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="15">
        <location>
            <begin position="282"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="14">
        <location>
            <begin position="367"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR011794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR011794-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2440622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="535" mass="56934" checksum="D877077D15FFBDA6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCN1</accession>
    <name>A0A9P4PCN1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_434045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCN1"/>
    <dbReference type="OrthoDB" id="3713693at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="163" mass="18728" checksum="84E0A80B2498178B" modified="2023-09-13" version="1">MDPKKLPVPAGWQAPAPLQYKHLTATILNEEDVQEDLAAVNSSRELIRRTRGGSWPAAELTEKDNLRDLQWHAREARDGGSFAYAIRNTEGEYVGCFYLYPFGMKTKWTEELSRYDVDANWWVTADAYSRGDYEVLYHGLKGWMEKELAAVGRPWWSNAEIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCP1</accession>
    <name>A0A9P4PCP1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_85860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCP1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="182" mass="20059" checksum="7AA018A84333D8B6" modified="2023-09-13" version="1">MLCKEGGSSNTSDAKTNRRISGKDLFVGDGVPYSSIILLLPPTLPNPIVTGICTPSSISRLMLLGPTEAVLILSFSLVTQPIHIHTDIFSFFHSSVLPAGQHISITILHSSFFGSARRTTHSYDIFHILSFLPSSWFPHHRILLFFLSTSTYARYTISPLLLHRTIAAPRLPVACKARFGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCQ9</accession>
    <name>A0A9P4PCQ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Heavy metal translocatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_434084</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCQ9"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000068">
        <property type="entry name" value="Copper resistance-associated P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000043">
        <property type="entry name" value="Copper-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1143"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1203"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="206"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="281"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2442614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1238" mass="134406" checksum="D8B210B3360821C0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCS2</accession>
    <name>A0A9P4PCS2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4F5 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_523475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="58" mass="6302" checksum="D696DB1B150B805C" modified="2023-09-13" version="1">MARGNQREKAREKNLKEQAGKKKGTNLTGAGFAKVKEDTAAIMRAKQAAADAKKTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD02</accession>
    <name>A0A9P4PD02_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_523631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD02"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040291716" evidence="1">
        <location>
            <begin position="17"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="450" mass="48483" checksum="52C3502DA1879554" modified="2023-09-13" version="1">MGPLYLLLGLASLAIAQLESTSIEIVTITGSSAISSGEAPAATVPSDFDGSTIATASLTRAVSGSTGATNATASGSSSGVSSEATYTQLVGGTRSSSTSTVLSATVTTSTAAPPVNTQPCNNYPEFCNRKYSNITEVCAHNSPFLRARNVGSNQELTVTQQLDDGIRVLQGQAHYINGTLYYCHTSCDLLNAGTVEDYLRTVTEWIAAHPFDVVTIIFGNYNWQDTDKNGNRTVTSKQFAEPIEASGLKQYVYQPPKTVMNLKDWPTLGELIISNKRVITFIDYNFDTAAVPYLLWEFYNIWETPFSPTSENFTCEIQRPDGLSENKSREMMYMANHNLNVQVSIAGLNLLIPNTAELNKTNGVNGSSSLGEMSQNCTGMWGRPPNFLLVDYYNYGSPMNGSVFEVAARANNVTYDRACCGKAASLGVILEMPSPKYLALAIAVVAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDC1</accession>
    <name>A0A9P4PDC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AIP3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_365607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDC1"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="3">
        <location>
            <begin position="458"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="887"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="971" mass="106473" checksum="DA7ADEADDF914B0A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDE5</accession>
    <name>A0A9P4PDE5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_85558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDE5"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2440921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="318" mass="35157" checksum="DE4D146F452DF7E7" modified="2023-09-13" version="1">MWGISYWAVPIFSSLVWLAMLIAMLTTWSVQGSPYYPSMDPNQRIAYISGLKPLFIAMSAITVVSLDLAFILERWLRHTGKLAPNTSIYQKIYSVCSIIASIAGAAGLILLSVFDTLRHPRMHDGFLVLFLAGYIVSAIFICWEYQRLGIHFREHSILRYSFWIKLTFILVELALAIAFGVTQKKELYDTAAVLEWTIAFIFFFYVISFFIDFMPAIRSKHHQSRETEMDMAEQGGMASMGDGAANDGQYFRGNTNGYANANGRANGHANGYTNGNGHANGYTNGNGHTNGNGFTNSAGGPGHIPKPAAPAPLPSRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDQ0</accession>
    <name>A0A9P4PDQ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_474389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDQ0"/>
    <dbReference type="OrthoDB" id="4652505at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="179" mass="19086" checksum="50CBF30DBBCBD074" modified="2023-09-13" version="1">MLVAGGWQLHYFSGPGATIERIQLFGGVVDNPEDIVEKTSETQVTFHTRTSGDFDGADIFSGFGLPRMISVTGSLGGYIKVGNVLAGNPYKPQPQFNLALTATADDAQFESKEISITGGVDLFVSAETLPDVDPRNVEGTFTVPARAQKAGDQKSVYFVGRKHVGGKVITSPVFVEFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDR0</accession>
    <name>A0A9P4PDR0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_419554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDR0"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="470" mass="52440" checksum="5532FE9567F19E67" modified="2023-09-13" version="1">MEKHTLAPGDVEQAAPSPIPTRASRATTKRLAVAVLVAVFLQLGFFFRHPLSHLLQSASCHQLLGQLTIEQRTQKILRENPLIDGHNDLLISLRMRYKNLIYSHDFKEKFEHGGFPQHVDLPRLDQGMQGGAFWSAFMPCPPGNGTDFSDERYAPIVKMTLEALDTYNRLGLVYPKYFTLTPDSYAAEQAFKAGRLISPVIIEGLHQIGNSISTLRLYHKLGVRYATLTWNCHNKYADAALESDENFAARIATPYWKGLSPAGRNLVLEMNRLGMLVDLAHVSTDTMRDVLIGNGTEEWKGSIAPPIFSHSSAYAICPHPRNVPDDILHLVKKRNSIVMVNFNPGFISCQPGKTPRDLPEFDPGNSTLDHVVKHIKHIGKLIGYDHVGLGTDYDGIESTPKGLEDVSKFPDLVAELLRQGISEKDVGKIVGRNILRVWREADEVAAKLQLTATPLEDDIQTPWSSEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE06</accession>
    <name>A0A9P4PE06_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_434910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE06"/>
    <dbReference type="OrthoDB" id="2884623at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053832">
        <property type="entry name" value="DUF6924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21962">
        <property type="entry name" value="DUF6924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6924" evidence="1">
        <location>
            <begin position="64"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="210" mass="24045" checksum="B1319200BB48A6D6" modified="2023-09-13" version="1">MPGIIIVTAEGADAPLINRLLLHVRDWEFMGGDLDDSDMFTVLTTQEELPKPQQAGNELITRPPIQDFSDNEWEGLSLEEVERIMIDKDTEKDGCTSLFLLLDDEGVENQTILVFNRGGNDPEEDSFGYVDEFNKMRVPWECVYSMWCNLDIANMGFDEFSTEEEGLDSTKGGAPRRWWTYKNFMDEGHYEPFKAKAEDAIKELKKLDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE26</accession>
    <name>A0A9P4PE26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_93532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE26"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="205" mass="22361" checksum="A4E06720AF3A9A0A" modified="2023-09-13" version="1">MIKRHHPCRDLASWHTGVHGIGLGGVASKLSCLIHHDDWQAVYPGLHLRPLYFGTCREPYLSLPASFVFEWKLFHVSTWAPTSRQTSHLPISGEVYGSIVNAVVAAPVSSPWFALISRGRLQLHWLCGSERAAHAHDRVVRMATNICHGLPPRLKSVGAVVLPSIPHCGADAGPSERVHTLARESTLPAHSSTGLRFLTSPVSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEP8</accession>
    <name>A0A9P4PEP8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_433574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2441973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEP8"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040225178" description="Acid protease" evidence="3">
        <location>
            <begin position="24"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="62332" checksum="B960AA8271A41A97" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF86</accession>
    <name>A0A9P4PF86_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_51232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF86"/>
    <dbReference type="OrthoDB" id="4364131at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="93" mass="10468" checksum="B3DD3FCF0FE24B47" modified="2023-09-13" version="1">MSLALRHVDQALLLSCNFNFRSGIYTSFFRLLPLQHVFLGLVVMISACHRKITSAGDRGSIPRGRVYFCDPVLCCSSSMQWVGMAVTFWSFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFF3</accession>
    <name>A0A9P4PFF3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pathway-specific nitrogen regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_474287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFF3"/>
    <dbReference type="OrthoDB" id="5369448at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="424"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="99615" checksum="53CB22A8CBCBF5D1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFY7</accession>
    <name>A0A9P4PFY7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_414887</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFY7"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2443416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="513" mass="56333" checksum="5BE7DFC7D49385E2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH22</accession>
    <name>A0A9P4PH22_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucooligosaccharide oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_433038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH22"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF15">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040144723" evidence="5">
        <location>
            <begin position="20"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2443880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="494" mass="53889" checksum="C5239B370C839C70" modified="2023-09-13" version="1">MKFLSTFTAGLLAAGHAAAAPSKAADACLKGKKVPASYPGDAAYDELAEPFNLRLQYKPAAIVLPETNTHVQDAVICASQSGLKVQAKSGGHSYASFSTGGKNGSLIIDLQPLQNIELDKTTNIVKVGGGVRLGNLAQGVWDQGERAISHGTCPGVGIGGHFTHGGYGHTSRNWGIALDHIVGLDVVTADGKLLHATATENKELFWALRGAAESFGIVTNFYLRTQAAPEVITYFQLQWGDTLFKNKKAFTDTFLHIQTFSQNASVVDNRISYGIYLDGNATYNLGGTFFGTSAEFNSTILPELRRGTAPPTHITVQEYAWIPYLILMSDKTDIKEPLTGYDDHDTFFAKSITVPEADGGLTATTLNNFWDYISKPAPYSYFVIINLYGGPGSAINTKDTKFAAYNDRDSLWVFQNYGTNPTSLDYINGINDVIIKSQPQTHFGAYLNYVDPSYSAKEAHELYYGEELYSKLATLKKKYDPKQVFWMPQAIGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHS3</accession>
    <name>A0A9P4PHS3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_415189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHS3"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000302">
        <property type="entry name" value="MFS siderochrome iron transporter MirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF50">
        <property type="entry name" value="MFS SIDEROCHROME IRON TRANSPORTER MIRB (AFU_ORTHOLOGUE AFUA_3G03640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="78"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2443578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="595" mass="65866" checksum="7409BF717B60A179" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHU2</accession>
    <name>A0A9P4PHU2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_445668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHU2"/>
    <dbReference type="OrthoDB" id="3758860at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2443171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="514" mass="57978" checksum="25DDF15CEE72559D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI29</accession>
    <name>A0A9P4PI29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_522227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI29"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="798"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="863"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="926"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="863"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1150" mass="124932" checksum="3FBE8CF51E1BDE96" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI36</accession>
    <name>A0A9P4PI36_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_473600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI36"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="341" mass="36543" checksum="39E6B5C31B925A07" modified="2023-09-13" version="1">MPNPLISNHHGKNGKYTKAFLEQNGPGDARPTALDILKDNGRVGTMKDKVFLLTGSSGGIGIETSRALAATGGKVYLGVRDLEKGQQALEGILEPGRVELLELDIGSMESVRTAAKTFLSKSNPQLNVLINNAGIMACPEAKTADNFESQLAINYLGHFLLYKLLEQTLLSSSTPEFQSRVVNVSSAGHHMSSVVLDNINLDGEYEAWKAYGNAKTACIWMTNEIERRYGSKGLHGLSLMPGGIATGLQRHVDIETLKQWGSSEPAQKYGKSPAQGAATTMTAAFGKEWEGKGGVYLEDCQEAGPIPEGGTLAVGVAPHAFDPEGEKKLWALSLNMLNLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIT8</accession>
    <name>A0A9P4PIT8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_432038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIT8"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="255" mass="26439" checksum="D795DD79DC2493BD" modified="2023-09-13" version="1">MPPKKSSTASTKKAAAAAPAHGSYIDMVKDAIINLKERNGSSRQAIQKYLKANNSLGNPTEAMFKSRVNGAIRKGLDSGDFSFPKGQKSGSIKLAKKDAKEAKPVAAKKEKAEPKAEKKTEKKTVAPKAKATATKAKAPATKKAPAAKKTTKAAAPKKETKAAAAKPKANASKPRKAAEAPAVPKEDFAVLSKTKSGRVTKTKAAVPTTKAPAKKAAKAPAPKKKTTPAGKASKAAAEPTKKSTPKRATPKKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIV2</accession>
    <name>A0A9P4PIV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_26305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIV2"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2444118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="338" mass="36310" checksum="59C19641F093B1CA" modified="2023-09-13" version="1">MAGASKLEKLPPWGNAVAGSAGAVLANALVYPLDIVKTKLQVQVKRAPGSYAEAAASSPDDEHYASTLDAITKIVKAEGVAGLYAGMTGSLIGVASTNFAYFYWYTIVRTLYLNYSAAPGTAAELGLGAVAGAVAQLFTIPVAVVTTRQQTTTKLERKGLLATGKEVIDSEDGWTGLWRGLKASLVLVVNPAITYGAYQRLKESLFPGRTALKPWEAFALGAMSKALATIATQPLIVAKVGLQSRPPPARNGKPFKSFIEVMQYIIEHEGPMGLFKGIGPQILKGLLVQGFLMMTKERIELSFILLFRYLRQVRAEKLQKLANLAAEKAQQSRPVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJZ0</accession>
    <name>A0A9P4PJZ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_443092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJZ0"/>
    <dbReference type="OrthoDB" id="10525860at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="107" mass="11547" checksum="97A1799A16056F6B" modified="2023-09-13" version="1">MQMYQWGTPTRSPGRTPRRAERVRIASTLWIVALAGRLSRVSLPYSGQQFTTSSVELSMVTEESQALVHPTGQMPGEYTIEVSESGKAGGKQLGVKAPGATNHCVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKA9</accession>
    <name>A0A9P4PKA9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKA9"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="197" mass="21708" checksum="50F2E51BC711C359" modified="2023-09-13" version="1">MSGLEAALFNLKFTAKSLNRQALKAGKEETTEKAKVEKAMKQGHHDIARIYAQNAVRKQNEKLNLLQLASRVDAVAGRVQTAVTMRQVTGNMQKVVKSMDVAMKSMNLERITAVMDGFEKNFNDLDVVDEFTREATSSATAVGTPQDDVDRLMAQTADKVGVELSADLEEATPAKTKIGPTEQEEQGLNERLRALRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKR6</accession>
    <name>A0A9P4PKR6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_272771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
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    </dbReference>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
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    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PFM_jacalin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
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        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
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        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040373531" description="Jacalin-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="633"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="174"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="633" mass="68801" checksum="BD9EEE56772625D1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLN5</accession>
    <name>A0A9P4PLN5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_430971</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLN5"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040206645" description="tyrosinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2445573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="622" mass="69590" checksum="D93FE0835FE62150" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLV8</accession>
    <name>A0A9P4PLV8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLV8"/>
    <dbReference type="OrthoDB" id="3690848at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48766" checksum="0559014C99743DE9" modified="2023-09-13" version="1">MRSNASLRCCDTEESGGADDINDSSAHFGTNDNPNASEWLALVVDKTEKAHLEWVAEHGYTKWRELPVEVVRLPLVDLSTAAVLSWRWDTDEADHPSRNIVSAILVAKKMGFRYLFIDVISIDQRLTGDALLERVVEFSTLYRTIPVIAAYDRIGADFKTTIRRPWISSELQAYRRNPTRIIYASHNDQGAFRGRTWFYGGPDESKSNFAFPLVAQRVWTTNFATTIIMVLRGWITMASLSDLSRIMPAYAPALTAAYDKMSRNDYLLAAAMLAQTEPMVTDIVNDDSDMQNIYHPGEEKLTSFRFVKTVSTMKQDSWDIVIGDGEHEVIVGSWTSRHNFYFNDAYYCRLTVNDKTEHAICCMALGMTESEFESYLERKKALQTSLSRMEGEDEVFSKIEVVTVDLEQGRCYNDQDHSPVPPVAAVESLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMM4</accession>
    <name>A0A9P4PMM4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_513481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMM4"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="58"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2445938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="490" mass="54382" checksum="EDC527C4628E2E91" modified="2023-09-13" version="1">MVSKSEETDIGVASSFESDAQPARKENAWIRFMTTLKWYPKDMPSEEKSLILKLDLSILIFGCLSFFTKYLDQQSLTNAYVSGMKEELHLFGNEINYLTATFWASYCTFMIPACYFLTHYPANLILPILEVGWGLSTFGLAWAPNVKTVYAMRFFTGIFECCSFTGTIYVIGSWYKPTEVGRRVALFFISSPLGTMFAGYLQAAAYKNLNGAHGLSGWRWLFIVDAIITLPIALLGFFVFPDVPSRKKPRFLTESDHLFAQKRIAGKTAPPQLRVSRSIFRRVFSRWHWYLFVAQWSIMDQNFLPSSSPFSLYLKANSHIYSVVRINTLPTIATAVSVVAAVTCGIVADKTGRFWLPSYVVTLPVIVGCALLVAWNVGESGRLAGFILTGFEGALSPLTMGWATVTMAGDAEERAVVTASMNAIGQGIMAGTQVVQYAATDAPRFKGGFVSNLSTSVVQLVLISVILWLSSRDKRKVHGEVEVGPSNRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMW8</accession>
    <name>A0A9P4PMW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_508144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMW8"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000080">
        <property type="entry name" value="Aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="40"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="460" mass="50132" checksum="16A46F76E809E1F1" modified="2023-09-13" version="1" fragment="single">NMSAVPSGDVINLQLGWPSPHLFAGASLLQGATEVLSSEAELAKALIYGPHIGHPPLRESIAQWLSEVYNVATSKNRICITNGASANLSNILQKFTDPIYTRCIFMVEPTYFLACPIFEDNGFRGKLKGVPESAEGVDIEFLRKALQASEAVAVAEKNNSPNLKAGKTYLRVYKYVIYVVPTFANPSGKTMSLDLRKQLVSLAREFDALIVSDDVYDFLSWPVDPMVACHASGSIPPRLVDIDSAMQGYSEFGNTASNGSFSKLIGPGVRVGWTDCSPAFAIELSEVGSSSSGGAPSHLTSTFVDKMLRNHHLQAHIKDVLIPEYSRRYYALMRCIAEVLLPLGVVVESNALTGVAGGFFTYIRLPADLPAAKIVAAIAWKKRQLRVAFGHMFTVSGDLGSLMRGEQAQGFTKCLRLCWAWHEAAEIESGIRRLAETISEARSMARQGLGFEEYTTIGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNI4</accession>
    <name>A0A9P4PNI4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_252924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNI4"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF7">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="280" mass="31968" checksum="5DA5CFED790EF97E" modified="2023-09-13" version="1">MRSHDTPPCIDRATFFSLPKELRLAIYSYILPHTESFDVRFQRGDGEAKPPTEYNLTFVLEKHDSNGVWKMQKTLPRSDREVGNEIVWRLGCISLLSTCHEIHDECVDMIYGENTFVIDVSFDTIKFRQRWRTANNLTPGRSYAFLDHFSQRNLMKIKNYIVNVEHVDDYTGMIKFNCGGRGLTAGIRGRVQELVDLLVAVPNLHRLHVHLIDGAISRVRFPSGRLHRVQDVQTFLTSQTVLDPFKGLYGVRTARVTGVSEAYAEVLEAGMAETRGAPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPC2</accession>
    <name>A0A9P4PPC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CIA30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_429293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPC2"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="3">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2447672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="245" mass="27793" checksum="0DE6497BF18D451D" modified="2023-09-13" version="1">MIKDKEHVFFGDDKSWKASDWTASDDRVRSGKSQSYLEISGSTARFHGHLDIKTLGGAGFASQRTVAEDGTWDVSHYDGILLNLGKSDGKRYTFILKDELLPRNPDNGREQATISWEYDFVVSEDAAQAESSFVYIPWKELKPTYRGKEKKGVKDFDTKNVKRFSLMMRSFFGDQQGDFSLSVKSIKAVSRPKDLEKSPTESERKATLRAPLLLSLLATTILAYGLCAYVCPWVMNTHTMKHWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPJ2</accession>
    <name>A0A9P4PPJ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_385594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPJ2"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="27"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="406" mass="44563" checksum="497E73FDC5B16397" modified="2023-09-13" version="1">MFRSVLPSPADPVYQLSQRVRADTASEKVDLGVGVYRNERGQYHELGALKAAKRILARQDANHDYEVTTGNAGFLANAAKVLFGWEADVISSGRATSVQAISGTGAIHLGALFLARTPAFKGKKVYVGTPAWGNYVPLFNLVGLEVVTYKHYDASTGTVDFTSVLDATRTADEGSIFVLQGCCHNPSGADFSRAQWDELADAMEARKLFPLFDMAYQGLGASLDDDAYGLRLFARRGFELLACQSFSKNFGLYGERVGVLHAVSGDREVAAKVYERLRCLIRWEFSSSPAYGARLVDIVLSNDELRQDWQTELATIQKRLADNRRALYAELVEKREAQGNWGSILSSTGLFCFLPLSPQQCERLAAEFHIHMLQNGRINVAGLSRSNIEHVASALVKVTSSPSSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQI4</accession>
    <name>A0A9P4PQI4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_193214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQI4"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="72"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="175" mass="19277" checksum="1435FEC05B93B8E5" modified="2023-09-13" version="1">MTSYYDVDAILTDAQKVPCTFELSVPALGFLEGNMSGDVKQGSKVELPLWLGEMLAISQSPSLVSLDHPSALSQRVLNALKADARTVDLRALAPHFYNLGARVLELFEEEEMIEVLSDAFKSRAAVIADQAHNPRGALGEGADFMRGLDENERQLFRASHDSAKAVRTWMNDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRY1</accession>
    <name>A0A9P4PRY1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_206823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRY1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="294" mass="31374" checksum="FB16B277ACE0885C" modified="2023-09-13" version="1">MPVDEATRRAVGGLEVRGARWRIGRRSRACDSAAGGAGFAGAASVCAVSSLAGVNFERAAVAVWGVERAADGGRACRRRAKPSAGDPVFIRGEGQNEPRFRLPQLSTHAPTHPRTTLHASQPNSILRATSCTSSALPVCTHHHWPSCCGGGLALRHAFLLPGEAAGAQRNSVCLYGRLFVYQYICYHGEAISRGLDCDSGLALTLSFMHTWPSSASREITVRCNFDTPKVSMTTSPHAKITARQPLRSHAKTCAATRIQCLFHDGPLTAAATPMWVRRASRKFPAALSDKSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS11</accession>
    <name>A0A9P4PS11_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear architecture-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_354924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS11"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="7">
        <location>
            <begin position="119"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2447821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="610" mass="65348" checksum="A8C54EC1AE5B3710" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSG0</accession>
    <name>A0A9P4PSG0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_426865</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSG0"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000377">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="149"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="284"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="307"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2450505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="394" mass="45556" checksum="DF13D7A9355977DC" modified="2023-09-13" version="1">MATAPAPDDPDERFASSQFIITLGTNIDFLDKKAAIFGQVVEGFDVLEKVNGAFIDDKGRPLKDIRILHTVVLDDPYDDPKGLVEPPESPIPSAAQLATVRVGHDETLDEETDPEALEKVRREREARAQALTLEMVGDLPFAEVAPPENVLFVCKLNPVTQDEDLELIFSRFGKILSCEIIRDKNSGDSLQYAFIEYSDQKECEQAYLKMDGVLIDDHRIHVDFSQSVSKIADDWRDNANMKRRHAAGGGFGGIDNLQRKKQYRGDHGREIVSDSVVNNLIIDRDAPSNSAKDRPRGPDSRQNGGRGKYEPQKDDGRRRDRREQSYHDDRWKRDRSRSPRRERRDRNGDGRHEDRARHEDRRRERSSDRYRDSRRDRSRDRPRRDDRDDRRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT09</accession>
    <name>A0A9P4PT09_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_427997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT09"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF8">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="106"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="481" mass="52711" checksum="43D062859E6BBB91" modified="2023-09-13" version="1">MLAQLAWKGFAFVYAAANLLAVLVLAGLRDGAFFKRPSKEAAREVQTAQKQYWSVGLNPLPGFSHRFFTLRNGVKLHYVVKTDSLLGKDSSGLSQDGTVNPQNVAVFIHGFPDSYLLWKKVLGAPSLDAQILIAVDLPGYGGSEGIKTYNANEVLEAMTEFILGMREKYLKEEAKMVLVTHDWGAVIGARLAAEASQLADRWVIASVLIPEHAYSHATAKAASAKQMLRTYVREPVRVSLLKNAYNTMKPVLSQFRRSFYVFIFSLPYPLAPIFPTFGNYWFLRLLHKAGHGRVAPNKYRKLTSKEAGDAMASSAGPGLAQLDEPNGYAASLKNRLPNNGMLEKFRIYREGLFRGPWEKSIETVVALSEIQSSGKRGSRSSGAGLFDIGPPGALKAPATIVYGADDPAFESRLALGGVGDYLAKDSQVLVLEDSGHWLPLEELGSSAIEEVVAWAMGGEEGALKERFAGKWKEKVRFHVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTE2</accession>
    <name>A0A9P4PTE2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTE2"/>
    <dbReference type="OrthoDB" id="5345625at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="382" mass="41178" checksum="DBB940569D84CB22" modified="2023-09-13" version="1">MSVSHANSPSTGTPRRVLGDLTPKALNTPSKRADPSDNTRAHSPLKQMQTLSPQLFGGKENVSTGALKSRKRSIDEVDDAERIDAKVRVGGSTTGHVGLSAAAMRLYTSNTTVDLPVPGSPTERNTPTPEPEPHHEPVNSQDTHDTQGTNNSFSALVNYDLCASQQSVQPAPSRAPSPPSPVVEGKKSRAELLRTRLGFGIYKVKTNQIAKSGSDIISSWETSYYDPTDASTPMVIPSFDGSRDAYQVPDITISSAKRDPQPVFIKANLDPFRPIGNLKLTPAPILLPTATSSRILHDYDMPSSPPHVILPEQLRSPVKQRLDYATPVNQSPRSDRAEQGFSDGSAQSGLRKLQRFQEGDLTSSAVKGNAAKGLMQLMAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU28</accession>
    <name>A0A9P4PU28_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_427495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU28"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="2">
        <location>
            <begin position="261"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="578" mass="63911" checksum="DDBC91E5250F5FBD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUH6</accession>
    <name>A0A9P4PUH6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_460797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUH6"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="19"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="401" mass="44485" checksum="2DB811A1030713C1" modified="2023-09-13" version="1">MIRFYNGPWDPVSNPDGLVNLGTAENSLMLDDIATFINGQQIQFTGEAFDYSEAWGSLRLRKAVSGFINTHFKPHTPTQAENITISNGCSALFNALGNVLADPGDGVLLTKPCYIAFGSDFGLLGGMTPVFIPSKDIDQFTPDILPQYEAALKSAKDRGIKVKVLVLCNPHNPLGRCYPPSTLTDILSFCNTHKIHLVTDEVYAMSVYSEDGTPFTSVLSLDWQKYIDPTYFHHVYGMSKDFASGGLRIGSLWTLNTELHRAVSALANFHHSGTVNALLACRILEDTSFTTSYMAKSRQRVAEAGLLARALLDEAEIPHAPANAGFFLWINLAPWLREEDGDDGWARERRLMERLIGERVFIAGGQMQNAEEPGWFRFVFTRKENLVREGVKRLKNVCGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUJ6</accession>
    <name>A0A9P4PUJ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_426894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUJ6"/>
    <dbReference type="OrthoDB" id="2328572at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="472" mass="52431" checksum="041B90089FD69E82" modified="2023-09-13" version="1">MNTIEFNQQTPEWQPPLTPSQPIPPTSTPRPATTTPKSANDRRPKLRASCDACAASKVKCSKEHPICARCRANGSQCIYGVSRKHGKPGRTRKRNPDGTPFIKASKQRPSPDGSEFSKFRVRPEPIISSREDTPSSNWSPTPSWPATPEFEFEMTPEPFYLEPSSDFNYMGDMSAYMPLQPEFQSFQPIQSELTFIDPFARKQSVRLDLPDIQAIRDFVTVDTVNPVNPLEVPFPESMPVDNGFLPPSNTVSPHSPKSTASYSQNPLRFSISMPTQHCCYTLAYQTLESLRIINPQNSTNVELKSLDSVLSITKEAVANVLQLLNCPCSSDPHLAMLYSSITSKILTWYQIAAGVQPTVPSTPPSLSAASSPSSSVFSSPLSTPSADNTTFNIAVQPITIGLFEFDEDMQQTLRRQVVLRELRKCGTLVEALANWGSPQKSTQAEYLYDVLGAWLKTELYKTLREVEGEQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVQ4</accession>
    <name>A0A9P4PVQ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="3 21">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">P171DRAFT_425823</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="21">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="21">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 21"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVQ4"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000002">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="23">
        <location>
            <begin position="134"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF2451306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="232" mass="25099" checksum="0B5A6D0DE5C6FA7A" modified="2023-09-13" version="1">MPALANTTRAIARSWTQHSLPVARAGCVAMQSRDASTSTFESPFKGQGSTKIPSFGHYKKTGGDENGPKVLSYFMVGAMGALTSLGAKATVQDFLVNMSASADVLAQAKVEIDLAAIPEGKNVIIKWRGKPVFIRHRTEGEIKEAEDTKWESLRDPQQDADRVKKPEWLIMLGVCTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPAYDFPEDGKVVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVQ5</accession>
    <name>A0A9P4PVQ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_152479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVQ5"/>
    <dbReference type="OrthoDB" id="3798144at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="218" mass="23917" checksum="0FB6BA9BEA21D43C" modified="2023-09-13" version="1">MHVPPTGAPPPSSRPPAHHLDSTRTATPRQVHTVTVRDFLTARHGFTLPSSHAYVASYDAARAHACRSLFRNGRAFGVHFHLSVNEDCDGGEEGGIKREEWEGVIKGQAGGGGKVVVWAHFERRRGVGLFGEVLGEGVRAAGRKKKKGREEGRRRVRVREGYALPPLNASPWVYFSRYTEIVPRPLPLPLRTVDGGKVSYLFLAGVRAQHTAIETIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW53</accession>
    <name>A0A9P4PW53_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_478362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW53"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="44"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="276" mass="30964" checksum="48683770E7C5A44B" modified="2023-09-13" version="1">MKSESDDSDDETKSDESDEDEAETNTKVQHRAAPRRGPSPPKGKSTKHSRSKVTLGGLLDVLDGPGAKEGRLVVCTTNSPYSLDEALARPGRIDRRIFLGKSSKLVAAITFSCIFGTDPRLRGKFSKRELNRIAKEFGDVVPNNTFTPCEIQQFCMKWQGKPERAIKEMPQWAKDKLSGAHVSSTTSLDIISEGDEIDTIYKRFYNLSHPDFAGLRNMYPYGKPLKDSDDENEKIVLLEVMDPIPEPPSPHKEDEPTLFEEDFSQKYAAWFGGLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWT3</accession>
    <name>A0A9P4PWT3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_459760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWT3"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000171">
        <property type="entry name" value="Glycosyl transferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="318" mass="36060" checksum="DEF3A7787F3DD877" modified="2023-09-13" version="1">MASSTVPHNTSSDAPAGGSKKVWTTLITNTAYLSGLLALDYSLKKHGTKYPLVALYTDTFPQEGHEALDRRGIPKKYVPYLLPKMGKDYANDPRFYDCWSKLTPFSLTEYDRVVQLDSDMLALKNMDELMEMELDPPSAAGKGQKVFAASHACVCNPLKKPHYPKNWIPENCAFTSQHDKPDEAQKQGAAPGFGLGMPNGGLQVVNPSHDVYQLILDQLAKETSMDYDFADQSLLGDVFHGRWVALPYIYNALKTLRHKGVHDKIWRDEEVKNIHYILSPKPWDEKPGEEKEESHKWWHAVNQERLAEEKKRNIKDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXS4</accession>
    <name>A0A9P4PXS4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_375280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXS4"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="448" mass="48656" checksum="1E6B0068A6185BB1" modified="2023-09-13" version="1">MCPFTSLPAGEGPARFSPSAVQDWIPRRKSVSNACERCRRRKIRCDGDTPCATCKRFSLACLRTQKPKEVVASEHQAALETRIHHLEAQLAAHVNAPMHGMGSIDENLMASTPTSFDWGQSPTSLSLDTTFASTFTSEPLQMDLGSFSAGGVGARLPAIAITKCELVPRAAIVSSPVPSFWSGTTRASSPDVPPTSAPSYPPTVLPVSTKSYTSSPDPPHATEWDFMSRRNKLKPEAPQSGSISRATSISSNSIESEEVGIEDEKDVLPLAPAPHLPRPGLFAAHTESPPPGSSRSTFTDRSRALTTTPFPSRFEAETLTSEFIQHLESAEQGRYSVSPGIFSHFCESVYPDPKNRGIALDIPVSTQMARFHVFMAMAIGMKLRIKASPENTNSLLDTCYDLAMQQSSSPPFWQENGGVEATQLLHIFASIRKEPQLAPKPLQSSMSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYA4</accession>
    <name>A0A9P4PYA4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_426040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYA4"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF5">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27863" checksum="13E99389CBF1967F" modified="2023-09-13" version="1">MASNTPTTPTIRPEVSALFQSVEQAFTTTSLGENRWYLLTLAALVGGTEPLLADQLYLYIINKPNCQQSDQRQKLVRTLRETLVKLVSIIGVCKPLEGILAIAKVERPEDRDYSFSRKDWANNSENHDRGMDWLRKIYTHNTDKTLSLFDAHKDFRWISTEITYGLYLSDRQVVDDIDTEVVVLVGIMIQNLPLETAWHIRGSRRIGISLEDVKTMMDCVRKVGDFMGTKLDRIPSADDIEKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYH0</accession>
    <name>A0A9P4PYH0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_346508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYH0"/>
    <dbReference type="OrthoDB" id="2421327at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018839">
        <property type="entry name" value="Tscrpt-silencing_Clr2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10383">
        <property type="entry name" value="Clr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="3">
        <location>
            <begin position="89"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic loci regulator 2 C-terminal" evidence="2">
        <location>
            <begin position="409"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="71829" checksum="75876AA93BFCB11D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U3T3</accession>
    <name>A0A9P4U3T3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_459286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U3T3"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF4">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2437209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47364" checksum="C20EB5B7B449C0A5" modified="2023-09-13" version="1">MSHTMNDPEKDEGALKDDLYSQANPPREGFTKADQKHMGLFDGGLAGLFWGFIWTFIAFSFVGLSLAEMASTAPTSGGQYHWVSEFAPPSIQKFLSYIVGWMSTGNAADCFITGTLTQALLQVNDENYVPKRWHGTLFTWAMALVLYVVNLWGHDFWPRIQNLLMVIHMLAFFAVITVLVFTGFSNDGGWNSMGMSLMVGQISAIYSILDATHDPSGYPFLYVFKGAMGPAGVNNLTIIVLLIVSAANINFGASTACQTFTFARDKGLPFSSWLTRVHTSKEIPANAILATCLITVLLSLINIGSLVAFNAIISLQIVSLMFTYFCSLSCVLYRRLYYLELLPVARWSLRRWGPLVNAVGLAYVMFAFFWCFWPNGTPVNAETFNWSVAMFVRVLVLALVMYAVEGRKVYVGPVKQCRMARLEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4Y9</accession>
    <name>A0A9P4U4Y9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0052-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_436942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4Y9"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="460" mass="49828" checksum="D94D3F030E153E55" modified="2023-09-13" version="1">MSSSKPKGIVVFSGGSAANNLVDVFKAVREDKKCQLSYVIPISDNGGSSSELIRVFGGPGIGDVRSRLVRLIPDDPDHDDSEKAAIKIFFNHRLPKDQATARQEWMRIVDASHSLWTNISTSKKELMRAILNSVNLEILKRMRPSSTFDFSGASIGNLFLTGARLFTGSFESAIYLLSSICSVPNHTSVLPAINTNFTHHISAGLTNGAIITGQNSISHPSETTALDTTPLTAHEDTERHDAIEDANLPGTLPTLRKQYINFSKAAEDDLPARIQRLWYINPYGQEIRLAANPAVLAALGAAQAIIYSIGSLYTSLIPSLILKGVGAAVANPAVKYKILILNSTNDRETGPSSAPFSALDFVAAIAKACAESRGKDGAVAREEYCDYVTHVVHLTGPGTPAVEREALKKIGIETIKVYGRRGEGEGFVRYDEKGLVQALEVTMGRRDPRAEKIRRNTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5X5</accession>
    <name>A0A9P4U5X5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_370272</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5X5"/>
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            <begin position="14"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58349"/>
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        <location>
            <position position="82"/>
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        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
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        <location>
            <position position="87"/>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <begin position="99"/>
            <end position="105"/>
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        <ligand>
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        <location>
            <position position="114"/>
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        <ligand>
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        <location>
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        <ligand>
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        <location>
            <position position="256"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29035"/>
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        <ligand>
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        </source>
    </evidence>
    <sequence length="415" mass="46590" checksum="739083D1F2B3DB3A" modified="2023-09-13" version="1">MASSSIKKIKVKNPVVELDGDEMTRIIWQEIKDRFIHPYLDIDLKYYDLGLPYRDETNDKVTLDAAEAIKKYSVGVKCATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPIVIPAIPRLVPGWKQPIIIGRHAFGDQYRAKDRVIPGEGTLEMVYTPKGGKPEVIKVYDFPEGGGVAQTQYNTSESIAGFAHASFKLALDKKLPLYMSTKNTILKAYDGKFKDVFQDIYEKQYRKEFEAKGIWYEHRLIDDMVAQMIKSEGGYVIALKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTFEAEAAHGTVTRHYREHQKGKETSTNPIASIYAWTQGLSKRGELDGTPDLVTFAEQLEKACVDAVNIDGIMTKDLALASGKKERSAYVTTNEYLDAVERRLKSSLKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U607</accession>
    <name>A0A9P4U607_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_449470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="MU001513">
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            <begin position="1"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2438276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="396" mass="43895" checksum="5D69C36C27332A0A" modified="2023-09-13" version="1">MAPQSSSTNQDAGSSEHSDAGPSADSDDITMSGGLTFSFSELDQMFPLPAPLFEPFAAADPGPPASPGPPPPEFRPENILRVAERLMNDPFATVEESLTREPSEEPLADFDPDEDTGMDAEIEDDPEMWDDKDAEGESDDDDAESESDDEDAEGELDDSLSVGEAAGSMRDGESSVKRGKRPRSSSSSEEPDDENTPILAGIRPNMVAIKAELIDMNNINIGGVICNTIPYWCRSARTQVHVVRYERDELEEADWICRNCAKENRLFVNRKEETNLTTYEQSIVSQTGCRIAHCKHPQCRMLINVENRFECEIVYNPRIRNKHVVMSYPVAKQGQLAMAWICGCSTTQSGKNAVIYRPHEKICGLPNCRRPRRQPGNYPILAPRQGENSKINRVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U621</accession>
    <name>A0A9P4U621_9PLEO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">P171DRAFT_492008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="249" mass="28094" checksum="CD9A3B56AD74AA39" modified="2023-09-13" version="1">MNPPESDPRLVAKSRSTSNNRVKHQPGKSSTVSNFAKLEDPANTTKQLKHHLASTFRPAPGTTMMLELLRSTAVLFFLTVTFCGFGWLLNPARALMSFCHKYLVLYVETVDRAINYAFINMLLFTVALFTPFYETFGILTLTAYLFLRSTYYHDNPEAILFRPLRWADHDQSWVYSRAGPTCLKKFSASILQYCRYLTLCLAGYVAFFCALPPVTVTLATALEPRASPAWLTPTRPTNPVVYIGLAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U642</accession>
    <name>A0A9P4U642_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U642"/>
    <dbReference type="OrthoDB" id="10601179at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="171" mass="18737" checksum="267E78BDD1998B03" modified="2023-09-13" version="1">MHAGRRKQAQASCSGPSLHGYTQVPGHVYGQCMRPLPRRMNACLKPSHDPCCCGGLILLPHVPLRDTGSRLHGTLSGKPSLSGAQRGGRQARPDGWRGETHSWMTTWHKQRCGVQLIVLRQIGSHHTGGLSGTCDSSSRWSTHMILAVAWDGQRQQAACPFRSLEARTKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U716</accession>
    <name>A0A9P4U716_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_397831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U716"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="871"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1276" mass="145982" checksum="858CC7FD3EBE9BF0" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U752</accession>
    <name>A0A9P4U752_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_320985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U752"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="115"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2439431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="236" mass="26197" checksum="A7D78B0C4C52B672" modified="2023-09-13" version="1" fragment="single">PNWPAFAPLIPESDLSLRETLSGQIVTMPNFFTATLCKTYVSFLSLLPLATTPGKPKRGDAVRVNDRFQIDDPAFAERLWSGTSLRKLVLGTAENDGLGMDAAQRRELWGGEVVGLNPNIRIYRYSKGQFFDQHYDDSNNVTLPGSPSVPARTTWTLLLYLTSPATGCVGGETVFYPELDTGKKKSKEPPPEPFVVELEVGLALLHRHGAHCMLHEGREVTQGEKWVIRSDLCVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7W9</accession>
    <name>A0A9P4U7W9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_501858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7W9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="178" mass="19568" checksum="FAA83F6B4F00DABD" modified="2023-09-13" version="1">MRQQTMSAATWMVAIEGEIPEMGVCAPSLARRSRRGTSPFSRPNTLVASGRATPQPSSRRYSCSRRDRRVGASAAEDFDRVMASALTANRRQLTDPQLDTKVRPASAANERSIVCTLGKTARIVSYVTSQHHQWPTCAKSDNGRAKKGTLTSKVFRVTDAVPPHGRREQAYCIPKVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U855</accession>
    <name>A0A9P4U855_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_475337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U855"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="33"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="302" mass="32994" checksum="7CBDA63910696F4B" modified="2023-09-13" version="1">MGLSEQDVEFKALDGTVLRGTLYPTSDRGPAIVMSPGFNCVKEMLGLPDAAARFQSAGYTVLLYDPRTTGLSGGEPRNDIDPIAQVGDYSDAITYISTLPSVNPSEVFIWGMSFSAAVGLCVAALDPRAKGIIAVCPLTDFTYTEEKLPMVLKKCAQDRASQVAGNDPFYLPMLDAQGRNPAGFGVGVDSEQYSKIVEAGKEIAPRHVNRTTVQTYYRMVLWQPFGLWRMIKTLPVLFVVPELDRLSPAERQLGHWDSLSCPKSKVVVPGVGHMEIMEGDHVDGIMTEMEKFLRDVLAGTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8G9</accession>
    <name>A0A9P4U8G9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8G9"/>
    <dbReference type="OrthoDB" id="3786440at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="486" mass="52668" checksum="AD6BFD915C71F4D2" modified="2023-09-13" version="1">MTVGREITTPSGSGMPRRLVNEHMTDNHVAEDMRPLIIDTVNDNDDTPTFTPQSGSPAMMVTPPGVSTFTMFSERKHQSSEITITPVVQRPRLRRHANTAPSGIVPMFPGAKPQFTPQPPRRAISSTTAHAFSRSGSRERRRPSKALPLTQVEMSKLGRTKTRSRMSRQKSKRNSGGRMGPKAKPLVWRMSSPPKAFELPPEIKPSFSGRDRVKVKLKSMEMIKVGFVNTEPRGLPSASASSIVNTPNVFYKRPASVKTETPPSPAGSSTPLGSGAPPRGSSPLKNAISPKRSSPSSSLKSAECSTSGTLFTRAKHFSLPLSPVAQCVPWRRSMVVQGPWRNRTPVPEESKPVYIPGPIQLEEKIFATPRRNTGANVEHLDDGSVPQAKRFSDLVVLDSITMYFEAFGVATEASDADKGEKCTKGYACCASATYSSAAPRWHSNHSGGDISVSKGIARRRIISNGFWSSGPSQTSVATAVKGQPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U922</accession>
    <name>A0A9P4U922_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_487976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U922"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="327" mass="35356" checksum="B0C0D62D7990DB11" modified="2023-09-13" version="1">MASPNEPIPPRRQRNSPDPNPTALLLLGPPNTGKSSLLSHLLPSNASSAPALHPTTEPHAYAAALPNGERVLLIDTPGFDPGAAGSTAKVVEVVSWICAFHARNPTRVRWGGVLYFASVTKAGVVTPGVVRVLEQLVGADDFSAVRVVTTEWTDEDPEGREAGVERDLREGFGTLIEGGAGMVRWDGGAGGALRIVRGVVNGCCDAGVVFRILREVVEERKMLVETGVGGLLSVALDERERVMGETLEGVEGEIERRGGLGSEDVLDFWVRWREDLEGEIGRVEEGKGLLGVGLRGMLRASGASWEEDEVGERRGRRYSFEWWRRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9I8</accession>
    <name>A0A9P4U9I8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_60161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9I8"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2442041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="645" mass="71874" checksum="4A4B8DA3F4A10420" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9Z2</accession>
    <name>A0A9P4U9Z2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_434233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9Z2"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="315" mass="34709" checksum="6DFD03AC4A26880A" modified="2023-09-13" version="1">MVRIAVAGGTGNVATEILRAPIASGHEISILTRSPPTTRTPGVTYKTVDYTDLAALTTALRGFDVCLSFLVVHLDTDCTAQKNLIHASIAAGVKRFAPSEWGIKNGSDVPPYANKDAIAGYLEELKAKGELGRMQYCLFQPSIFMDYFAHPRPLSPGLITWPFFVDFERRRAMVLDGGEQPIVLTAIADISAVLDLALSDTDVWPAVGGMRGARTSINELLSLGKKLRGGEWSVEHVRGEDIERGVLTASWVPIMSHPVIPQDDREAFSREFVIMFFKGIMRGAWDVSAEWNEKFPGYKFTGLEEYLSRAWDGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAK3</accession>
    <name>A0A9P4UAK3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_365243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAK3"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2442313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="315" mass="34009" checksum="D2F3861F7C540322" modified="2023-09-13" version="1">MGGKKENKAAYFDKLKALLEEYKSIFIVTVDNVSSQQMHEIRQSLRGEGVVLMGKNTMVRRALKGFVGDFPEYERLLPHVKGNVGFVFTNSDLKEIREKILLNRVAAPARAGALAPLDVFVPAGNTGMEPGKTSFFQALGVPTKIARGTIEITSDLKLIEAGSKVGASEATLLNLLNISPFTYGMGISQIYDNGQTFDSSVLDIEESQLLKAFSSAITTIASISLAVNYPTLPSVIHSVVNSYKKVLSVAIETEYEWEEIKELKDRIANPEAYASSAPAAGAASGGEAAAPAAEEKKEEEEEEDSDADMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAW2</accession>
    <name>A0A9P4UAW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_446159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAW2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="348" mass="37400" checksum="8AD1E0A7DA4948F1" modified="2023-09-13" version="1">MSILGGSAGIRGLRMQGPHGGVPSALALRKDNMVDISFGAAQDGYDSRSGARYASGLRREDSQCRRRRPRVASRPYYTWKCNMRRTETIQEGGFTIGGPTYNGSEGLQGGRTVAGLSHSRRCNDDGGEGRFRAASVATGGVRFITPRMHPLAYTPGEGEGHGSCLTGVGVEEREMHNDEGLYRRNGWARSASELACCAHPMADQQEKREAPSPPPAEMGGMPVTTFATFGQQCQQATDTLEPARTRSDRENRRTWAPPSSTVGVVTDGKEFESTAGVVPLPMSAGRVPTDSASTLGRAESVQLECGAKPDWSGMEFFARAGTATAFRSARALAQAPYWVQDTMARDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBG4</accession>
    <name>A0A9P4UBG4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_522740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBG4"/>
    <dbReference type="OrthoDB" id="3799276at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="450" mass="50673" checksum="D92F1CF763AC7333" modified="2023-09-13" version="1">MAIEIAKDATGLGVTLTLGLSMQVALLIVPLVMILAWFKGIDKMTSGFQGFSVLAFFALTIVTVILTGLIGALVLQVFVIIALATFYIDTVVVFDEEPAYEGRYEEGVQENHQLDKLHAQEDNSGTNVVTGTVNNNEDIHAFLYDDIGDAQRHYDSLIDMSMVKFILQPYKCTVCQQPTSLPLPTQWSQRICTTCQTSLDSDAPLRFLHDIIGKMYAFWISMRREEHCDRIDRIIIPGLPTYIGINKGDPKHKTTLPQITDVLIHTRKGTQAAMRTLLPEQRNLLEEVLLTTKQCHISLTVFTQLFQRLVSAPDTPIATVQELSYNPKGIADVICNSHCVHIVALADARRFAVSLTDRQLGWYPLVVPWEEYRAERVGFVAPDGNGKEFVPDLGYVYARNAYRLRNPQFRLPNEPERNGTLQWIRGLELADEIVGRWEEWLVKEGVVLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBP9</accession>
    <name>A0A9P4UBP9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NIF system FeS cluster assembly NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBP9"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="127" mass="13980" checksum="731DB863820B768F" modified="2023-09-13" version="1">MEAYRERPANLLLLLDHYNRPRNVGSMSKADTDVGTGLVGAPACGDVMKLQIRVDPNNNTISDVKFKTFGCGSAIASSSYLTELVRGMTLEDAAKIRNTEIAKELCLPPVKRESLLPCEVCEYRSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCJ5</accession>
    <name>A0A9P4UCJ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7626 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_454843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCJ5"/>
    <dbReference type="OrthoDB" id="5321209at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056043">
        <property type="entry name" value="DUF7626"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24625">
        <property type="entry name" value="DUF7626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7626" evidence="3">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="511" mass="57236" checksum="16D860587A8083AE" modified="2023-09-13" version="1">MAPKGQPDIEFMLELSVYPATTINTSKIKDEDVGGDNQSVASFGDDIAPDEDINFAHYDEVPPSDPMTYDNAQPAHFYQTTLAAERSAQRVTADDSVNYHIEDDAEIAYTAPSRVAGTFGRVNREKGSTLPAYHKKVSHELDSDDELIMAMREKGFSDKQIAQRLAKEGRIKYNSKSVSTRIQRIKVVQAQRADFELENGIIEWQLEDDQLLLRAYDLASIEIAYEIERLRAWRFKKTAEWMRRMNKDSVFSGRACHARYAALLDGTATIPCDVDDDPPARHAALDAFRRAKEAERDTERDAKEALAAAQERIKLEAAARQAQLNLEKATKQATKKAAANARATKRATKKTLEARQAEDHLKKKTAAAADKAARHAASEADVKFRADFALKHFRHVTDATPDPRRVLDLQDLRKLCRARKMNDHVRRGEGEVKKVLLGRLREADEALRLTQLRALLAERGIPGGGTKVQMKYQLALFAARECDSYVRDGEDEEEGDGGDEAEGMEMDGGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDB2</accession>
    <name>A0A9P4UDB2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_431771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDB2"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="173" mass="19133" checksum="2372370734275BA0" modified="2023-09-13" version="1">MSQVVGKTRLAYARAWHHVDVASDERALGRLASSIAITLMGKHKPIFDPSTDCGDYVVATNCEHIHVTGKKRAQKLYRTHTTRPGSLQEISLENLAKKWGGGEVLRRAVSGMLPKNRLRKGRLERLKTFEGEGNPYKQNFLKVSNGGGQGIIDFAEVRKTLQAAKEEKVAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDB9</accession>
    <name>A0A9P4UDB9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-splicing factor cef1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_429282</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDB9"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="387"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="669"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2447664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="87198" checksum="53150C586E89E8B5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE25</accession>
    <name>A0A9P4UE25_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pro-apoptotic serine protease NMA111</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pro-apoptotic serine protease nma111</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_358301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclear serine protease which mediates apoptosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2446018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE25"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06786">
        <property type="entry name" value="cpPDZ1_ScNma111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF8">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="313"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="886"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113872" checksum="14EE86F57106449F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE51</accession>
    <name>A0A9P4UE51_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_430318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE51"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000005">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2446093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="231" mass="24946" checksum="B40F7453429FD278" modified="2023-09-13" version="1">MPRTASLNRDTNETKIQVSLNLDGGALPALEPSPFWDAIDAAATAADKDKDHASQQSTSQAISVDTGIGFLDHMLHALSKHAGWSLRLRCRGDLHIDDHHTAEDSCLALGAAFKEALQGSTGLARFGYAYAPLDEALSRAVIDLSNRPFCVTELGLRREKIGDLSTEMVPHCLQSFAQASGTTLHVDCLRGDNDHHRAESAFKALAVAIRQATTVVKAWEGEVRSTKGVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEV5</accession>
    <name>A0A9P4UEV5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_427533</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEV5"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="6"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="380"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="609"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="764"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2449329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="940" mass="104154" checksum="041147D94E36E870" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFL2</accession>
    <name>A0A9P4UFL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_228706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFL2"/>
    <dbReference type="OrthoDB" id="10569772at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="163" mass="17405" checksum="CF0D471AF811617A" modified="2023-09-13" version="1">MARPPSLFRSRYSARHFPCLCFMMSFPDHVAVLSSCRLTFPSAVATRVAKIKVAMSLVSWHPAALAHQAPLGLSWSGANLRSIVRTAQHLRSRVCHARRTTGFQCSRSRGHATHMNGSGTTRASGEGGTPNVALSRAEGGASRHQAIGACICIACTSSLHHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFN4</accession>
    <name>A0A9P4UFN4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_428360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFN4"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="133" mass="15255" checksum="D0D276633CC0B554" modified="2023-09-13" version="1">MADSQVTLRTRKFIRNPLLGRRQMVVDVLHPNRPNVSKDELRGKLGELYKAKKDDVSVFGFKTHFGGGKSTGFALIYDSAEAMKKFEPHYRLVRYGMASKIEKASRQQRKQRKNRGKELRGTAKTKSGDKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG68</accession>
    <name>A0A9P4UG68_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG68"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000018">
        <property type="entry name" value="RNase III domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="106"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="268" mass="29229" checksum="DE0E3537789D1AA5" modified="2023-09-13" version="1">MASPRPLRSLLSTATSALGAAQPAQRALVRTSACAFSTTAPSRGPEYDTEAAVRPRWQQTPPRMVAPYRVRPKPQGPEFKVNQDPRRLDEAYSRMLGPGGDKVLSDEVKWLAVTHKSFDHGKRGFNDRLAYLGRRIVSLQTSQALLNAPQVEAWPRKSDGLPLTDSYGRMPFVHPALNGLPGLTGEAKGRVLDKSRLAGLAERYGLDKVTRWTPKRADNLQSSGLESVLNTSLYAIIGALALERGGEVANKVTQDKILAPLGFTFTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGE8</accession>
    <name>A0A9P4UGE8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_404781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGE8"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24751" checksum="3367BF880461297B" modified="2023-09-13" version="1">MARQPGLVRRLWWSWKMLPLPWRRRTLAGFDLDGNTYWEWKIVKHARRTRRIVEYPGGAYNSDVHVPPQWAQWLRQTRPEAPTMAEQQAEAMRQERIKILAAQADARWAAKPSAVDAPDKQQPVQMLESRDPDTSIRQMNTDQETRDRAESRSPVTDNGIQEEAPQSDAAPALKTRKPMRTEPKDSPWKQAAAKGNPGDEWQPASWSPAPARKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGF3</accession>
    <name>A0A9P4UGF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase get3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_427711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGF3"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="10">
        <location>
            <begin position="27"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2449511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="341" mass="37990" checksum="5D2FEAB26BF135F2" modified="2023-09-13" version="1">MANAAVLNDDDVMEPTLQSIIDQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKHRKNVLLISTDPAHNLSDAFNQKFGKDARKVDGFDNLSAMEIDPNGSIQDLLAQGGESAEESMAALGGMGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIIFDTAPTGHTLRFLQFPTVMEKALSKISQLSRQFGPMLNGFLGASGQLPNGQNMDELIEKMETLRSTISEVNEQFKNPDMTTFVCVCISEFLSLYETERMIQELNSYEIDTHAIVVNQLLFPKKDNPCEQCNSRRKMQKKYLDQIGELYEDFNVVKMPLLTEEVRGSKKLESFSEMLVKPYQPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGY1</accession>
    <name>A0A9P4UGY1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_8922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGY1"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2451594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="167" mass="18873" checksum="7B09B85F17D05D75" modified="2023-09-13" version="1">MDATSQPSLDTVGATFGLLTSWALRTPTSYGIAIVLLFTLGLLGRFLGAIKWQLERSWRMSQRNTNMDHRSYLDLNDNDGESQPLSPEHSLAASEKRRQVRQFWSADEDRNMKQDGIRALLEFARAVIAYILMLAVMTYDVGFFFSITASVLAGEFLLGRYSRSSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIV0</accession>
    <name>A0A9P4UIV0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_144107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIV0"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-Gid-type" evidence="11">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2450682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="428" mass="48497" checksum="E5F5CB16CC972FAE" modified="2023-09-13" version="1">MAPPPPPTGMLELLEQLDVLEKSANLSASIHDVQSVIDLLTAARDKVAADPQTAPLTLAKLQDPVKRSLEQAQKDIKPIYSGLNKYGKALDKKFKDKPIPPASNDALSSHPRLVNRAISMHLLREGEFSVASTFIQEAHRHPPRPEPTASTPNPSMNDSREADLAEESFNSEKLQGQFREMYLILHELRQERNLEPAIRWARQRSDLLEARGSNLEFELCRLQFVCLFVGHGLVADDDEPMEEDPQGPLEAYKYARREFGHFRGRYAHEIQQLIGAMAYWQNVVDSPYRRYFYNNTAWEEVATSFTREFCSLLGLSADSPLYIAATAGAIALPHLLKLQNIMEKTRTEWTTQNELPVEIPLPPTYHFHSIFVCPVSKEQSTDANPPMMMPCGHVIAQESLDRISKGTRFKCPYCPMESHPRDARKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIV1</accession>
    <name>A0A9P4UIV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_426508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIV1"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="589"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2452121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="648" mass="71846" checksum="D0F141871F555737" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIV3</accession>
    <name>A0A9P4UIV3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_324365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIV3"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="36"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="154" mass="16988" checksum="065206D3E1CA1E47" modified="2023-09-13" version="1" fragment="single">MFAPSTSVFTRTLLTTARARTATNIVPVTAATLYRPLFTPKFFSNTATMSKEGVHNLTSKPDWEQALETQDTLLVLDCFATWCGPCKVIAPQVVKFSNTYPEARFYKIDVDEVPDVAQELGIRAMPTFLLFKNKKQVGEVVGANPKALEAAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UKA4</accession>
    <name>A0A9P4UKA4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_20229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UKA4"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF118">
        <property type="entry name" value="CYCLIN, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="69066" checksum="03727A7B64A4EF3F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P3E6</accession>
    <name>A0A9P4P3E6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_491931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P3E6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="175" mass="19875" checksum="39D9B501AB92FCE3" modified="2023-09-13" version="1">MSAPKDVQRPTQRLTLQDFEIHGRAGSSQGLRIISKVKYVANNHDVSLLDGTTVEKFCVGVGGNIWAFVDGGKLPYCEDIFYAQYPDSELGEYIMRQIPQFPRSPHIGIRYPFNKATTYDQIIALLHYIHLKVVLILSPLKTKPLVDELDLDPQVLQYFADFCKQVASEEQNEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4T7</accession>
    <name>A0A9P4P4T7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_437774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4T7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="90" mass="9788" checksum="DF748101DF854AF4" modified="2023-09-13" version="1">MSPALQSAALQTATVARSRSGDNPSVSTRPCCNWAAYAQQPARSIQLALFVRRGIFSHPLLPRSSRPPRLPTFTVLALQSLTAYSRLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5Q4</accession>
    <name>A0A9P4P5Q4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_400455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5Q4"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040167054" evidence="1">
        <location>
            <begin position="20"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="464"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="833" mass="88740" checksum="4B3525074163CA51" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6Q8</accession>
    <name>A0A9P4P6Q8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_526165</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6Q8"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2438496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="504" mass="54704" checksum="E663EA532BBDE44A" modified="2023-09-13" version="1">MSGPVEGEAAAPPAVTPQAPNDPAAPAKTDPKETKPADDGASKKPSGAELKKLKQLEKQAKRAQAKAIVPPATQQGGPPKENQKQREQKQSQKKDESRPLPIRRRPSQSNAVPQQQAKKESTRGQKNLGLFFGHLYSQPRQHSMVGASKDVHPAVLALGLQYSSYVICGSTARMVAMLLAFKAVIESYQTPVGTSLARHLTNHHLSPQIDYLRSCRPLSISMGNAIRWLKDLIIKIDPSTPEAEAKRDLVEEIDMFIRERVTAAQKLIRDQAATKILPGDVILTYASSSIVEQTLLQAHKAGVPFTVIVVDSKPLFEGKTLARKLANQGITVRYYLITGASHAVKDASKVFLGAHAMMSNGRLYSRVGTALVSMLARSHSLPVLVLCESVKFTEKVALDSIVGNEVAPASEILSEAERASLLPLEPHLPATHPSKNKAEDKHAADDAKSGPLDVIKWVEGSDNLHHLQVLYDVTPAEYINMVITEYGSLPPSSVPVVHRLSTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6T0</accession>
    <name>A0A9P4P6T0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_491859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6T0"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000636">
        <property type="entry name" value="Serine peptidase, family S28, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF109">
        <property type="entry name" value="PEPTIDASE, FAMILY S28, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040282331" description="Peptidase S28" evidence="6">
        <location>
            <begin position="23"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2437516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="62963" checksum="D72D16ED62280C28" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6W2</accession>
    <name>A0A9P4P6W2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_173433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6W2"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="287" mass="32700" checksum="8642E15B7F148F5C" modified="2023-09-13" version="1">MTRRTSPSEDDWRNVQDAKERKKIQDRLAQRARRKGILSAACTFGYREPKRTGIEANWWRYLGQRLREAKIQAKRQSEEGETRGGVVAQHQQDESSALLRPGADCWLVTATGVQEMAPLMPDADTSASTSSASPSFGFEDFLPYHLTNIPISDTLTNPLPIPEFSSISPEYPLTLYGSLYINGMYLRIPCSTVVPAKSDPVGPEVPESLRPTEVQMITIHPRWIDRFPFPKMRDSLISLSGVIDYEEFMRDLALMPSFEIIQGKPPWDPKSWKIQKPFAEKWGYLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P781</accession>
    <name>A0A9P4P781_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P171DRAFT_155934</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P781"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2438766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="454" mass="49714" checksum="BD07C68FC81FE066" modified="2023-09-13" version="1">MTPIWHPEYVVGPDVKDKQTILNFANMSEDAYKPSRDDPEWLDVGKNFGSSLPFGWEDTGIRGHVFSDDTNSTVILSVKGTTVAMFEGNGTSGRDKDNDNLFGSCCCGQNGPYLWRKVCDCMTGTYTCDEQCVKDELLQPNRYYEATLELFDEVIQLYPKANIITTGHSLGGALASFIGLRHGLPSITFETYPQALAAARLGLAVRGQDSPLRENTGAFHFGHTADPIYMGTCNGGSSFCSIAGYAFETVCHTGKRCAYDVVKDWGWRQSTQYHRLRYSIDEVYAKYDEAAPCVDEDVNCVDCYLWKFENGTKKHTTTTTSSSTSTSTSVTRTETCKTPGWWGCRDATTTTPTTTTSPTTTTTSTPTSTCETPGWFGCKDKTTSDATTTSEATTTTTCTTPGWFGRCLDPTPTTTTTEAAQVYWRTSPTATQTARAGAAYAYRHTEPTATQTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7E9</accession>
    <name>A0A9P4P7E9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phospholipase D/nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_437447</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7E9"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09194">
        <property type="entry name" value="PLDc_yTdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000038">
        <property type="entry name" value="Probable tyrosyl-DNA phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2437831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="601" mass="66681" checksum="8E9334EE678F0A5C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7G8</accession>
    <name>A0A9P4P7G8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_448934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7G8"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2438886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31349" checksum="183863DFA6A3EFBC" modified="2023-09-13" version="1">MSDKLKDVVKEEIEQARVLAVDAARSAAYLYPLKGIAFFFTHRALWRPLADKLVPTISLGLGVTVFMFAVTYVPQAAVLSVFNGPLAIVSTILLVLSEASTVFNVLSKNFLIDDALIDTFDGTLLARDQQALVSQERQMKGGSDYMARLGKITKKPFERFTPKAIIRYFLYLPLNLIPVVGTVLFVILQGRKFGPTAHARYFQLKQMSKHQKEEFIESRKAAYTSFGIPAVLLELVPVAGIFFSFTNTVGAALWAADIEQKKAPGETTAPGLRSQAEAASRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7N3</accession>
    <name>A0A9P4P7N3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_423510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7N3"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="292" mass="31998" checksum="C7C651CEA955295D" modified="2023-09-13" version="1">MANPVYSSPEWYLNAQDKDVSSDIGRLTIYHLGFKQAAEGTLLFAPLDFSNAPRAVLDVGTADGLWMREVQSSIPAPPQGEHKFIGTDINTSFFPSTATKNITYVKQDIRDATPKAWDNAFDLVNLRMILIAAGSGSAQRAVVNEHIKLVKPGGWIQIGDCDRVCPTPEAENPRYHEMFACIRAVCQSSGLDPLEAPKMKSWLEEAGLEQVQERTAMRAVGKRNGDEALGKLGIGADLMIAKGFATGAKGLSLSLKPLPDERLNSLVQDLETELTETGAYFPMRFIWGRKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P806</accession>
    <name>A0A9P4P806_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_491510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P806"/>
    <dbReference type="OrthoDB" id="3777306at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="160" mass="17354" checksum="0D70104B460207DA" modified="2023-09-13" version="1">MLSQRGTDIAVRAGAIDFSALTGLAAPSLAARASAANTTRRIWIITGVVILVSLIIIGAFCTVVLCFMHKKKRQRQKQQLDLGVSSANHRYRPVDDMELGYGGVQELPAENSFGGGGGKAELRSDFEVQRVQQLDGFVAPPKPSAQPVELPTSYKNDYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P887</accession>
    <name>A0A9P4P887_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_159410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P887"/>
    <dbReference type="OrthoDB" id="5393606at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="374" mass="40560" checksum="E7254CA1B546271C" modified="2023-09-13" version="1">MAYDNPHGLIAAAVIVQTLVLLMIGSRFASHKMKALGFHTSDYLIIVAGILSTALGIEQVYCAANGLFSVKVAPLQKADPAAAVDFLYRLRMHNYAFVVTGILAVGFIKTSVSFFYLQIFSVPKYRPYITTWIVIMTLWTVSFFTAFMAICGDHGIFSSRSHMNPAVQKKECGSTQKLDFGVLISDTVSDLITVLIPLPMIFALQHLPLSDKISIAAILLVGLLSVGASAARSYIGIYTKFAPKDKIMDPGLGVTATCVWTLIEIQVGILAACAPTIRPVIRELVHNGLFSGLMSAASSIVSRKISRSNIQDSDHAHSQYESRLKGGADEEEIIQLHDMSGANSSSAEHVYGPEVHKNGTIHVSKGYTVDEGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8J9</accession>
    <name>A0A9P4P8J9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_490879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8J9"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11605">
        <property type="entry name" value="RWD_DRWD_ELF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="226" mass="25005" checksum="CCC2CBE71EA5AD69" modified="2023-09-13" version="1">MELELVEAMYPDQVAYDSKSRDFKFTADSGALLQLRIPESYPESGFPDVLGARDGQKNDLREQVRSAIKDDVGLTEGEEALDAIVAAFQSVVDAKSATVDAENNVNQPSDTSKQPAPDKTVIVWLHHLLALSKRKLALSPTSISGITKPGYPGIMLFSGPATAVTEHVNVLKAENWQAFQVRYEEAELWKFEHGTGIREVETMAEVVKGLQEEKKRDEFLKAMGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P960</accession>
    <name>A0A9P4P960_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_106504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P960"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2440710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="361" mass="38185" checksum="E472508E7DC741D5" modified="2023-09-13" version="1">MSTTPTPYKPSPLSFNSPRTSPFRRPSTLAQSPGNSPSTARPTTPSSSPLKPTPDSTPLQAALQTAAPLRKPAASNASQRPPSWLNTRGTSLEPDIPKSPSRQVPTSTQHTIRASNTASIAARFDGGARTPPLERTTSRELPVERPIERTSSRDHLPALSRPANIDPPPPLRPATRPAMAPRTTSTDALSKIPPPLLHSMRESFSVMDRDNSGSVDAADVAEMLSQLGLSATPSTLNSYFTDGTKNINLATYLNTISDLLSGLSHPNELNAAFEAFDDGDDGQIDLGELKDALLHTAPEPGEHKLTEREIDMVVEGFSGRRAFGKGGKGLGRGEVFRYQEFVASVTGGGNAENGGGAAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9F1</accession>
    <name>A0A9P4P9F1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_395682</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9F1"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF4">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="11">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="204"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2439757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="389" mass="41628" checksum="C335D010504F1E90" modified="2023-09-13" version="1">MSPAVTTTNGVATNGAVKPNKTTISTPLPNPSLQVTADHNLKQVEAPVYAPGIGEVLLHIKATGVCGSDIHFWRHGKIGSLVVEGDCILGHEAAGIVLQCGEGVSNLQPGDRVAVEPGVPCGVCFLCMEGRYNLCEDVQFAGVYPYDGTIQRYKCHPAKWCHKIPDHISFSEGALLEPLSVVMHGINIAGLSLGRGAVVCGAGPIGLIALAAARASGAHPIVITDLEPKRLEFAKKFVPSAITYQVQKTLSAEENSKEIRRLFNFEHVGEYGAPEVILECTGVESSVITACYTARRGGTVMVIGVGREIMNNLPFMHLSLAEIDLKFINRYRDTWPAGLQCLGGGVLDLKPLVSHTYPLEKALDALHTCADLSNGSIKVQILDEEENVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9L5</accession>
    <name>A0A9P4P9L5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_85808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9L5"/>
    <dbReference type="OrthoDB" id="2305901at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="643" mass="71696" checksum="52DC2495A8A42F5F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAD9</accession>
    <name>A0A9P4PAD9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_329353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAD9"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="127" mass="13448" checksum="97FE45AE8DEBBF59" modified="2023-09-13" version="1" fragment="single">GSPAASTQTVAVGKDGLVFTPDTIHANTGDEIVFEFYPKNHAVVQADFNNPCNPSASGHGIFSGFVPSPAGRAVSNKTFTVKIEDDKKPIWLYCPQNNPKSHCASGMVAVINPPQYSPNTLSAFKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB42</accession>
    <name>A0A9P4PB42_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_489585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB42"/>
    <dbReference type="OrthoDB" id="4790878at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="366" mass="42552" checksum="E37FC7DFEEC49D95" modified="2023-09-13" version="1">MTEPLVNDKETESRGERATTDVATSMAGLLIDKVDPSQPPPDGTCHFFRLPRELRDLVYEYSLSEPFGLYWFPRPGDFVAKIKVFEDTVYFEGDMLADDNKPWWDWYADPGDNHFQLFSCFDDTQKKEGMEANQLKYVCRQLHEETSGLGLKFNNLHFENSDISVPITQCFEEFIKSCVPKRLAEIGSVGLTDCYFYCEDEYWEKELEKELRGNRPDPRDVHPKIMFDFLAAYPQAQLCLTTGPSNESWKFGDLFHKGCYMRYAIDGSKMEHLLVLPSEFQEDIETVGLQLRRGATLEELNRPNFNLYPPRRMKFDEEKIRAELTTDQHRDFSLWVQNSVRGGVDGYVAELKRWFVKGIRSDPGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBC5</accession>
    <name>A0A9P4PBC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_435543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBC5"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2440777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="256" mass="28735" checksum="5263CF68166A3450" modified="2023-09-13" version="1">MADVATAPNPNQQVPLDTIPISPSDETSSESKDQGSTTATSDGEIRTVFHDSENFNVKHPLMNTWTLWFTKPPSGKGDNWNELLKEVISFDSVEEFWGIYNNITPTSDLALKSDYHLFKQGVRPEWEDAQNKHGGKWAFQFKDKKAVNIDALWLHVMLAAIGENLEDEDDNEVMGVVVNVRRGFYRIGLWTRTVGKALPNDQNKGRTFDQGKETLSKIGKRFKQALQLKENDPVEFSGHTDAAHAGSTRAKAKFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBQ0</accession>
    <name>A0A9P4PBQ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ER-derived vesicles protein-like protein ERV14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_435276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBQ0"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="138" mass="16213" checksum="A75BC60BF509B647" modified="2023-09-13" version="1">MSGEAWLYLLAVLINAVNLFLQVFFTIMYSDLECDYINPIDLCNRLNTYIIPEAAVHAFLTFLFLINGYWVALVLNLPLLAWNGKKIFENQHLLDATEIFRKLNVHKKESFIKLGFHLVMFFFYLYSMIVALIRDETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBW4</accession>
    <name>A0A9P4PBW4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_62743</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBW4"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000026">
        <property type="entry name" value="Zinc/cadmium resistance protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="317"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="395"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2442165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="535" mass="57571" checksum="2B9D4DBE3D8A234D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBW7</accession>
    <name>A0A9P4PBW7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_99607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBW7"/>
    <dbReference type="OrthoDB" id="5425130at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="629" mass="67449" checksum="BCBA2AB2C8AFCAB5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCC0</accession>
    <name>A0A9P4PCC0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1748-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_420388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCC0"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="76" mass="8529" checksum="A36E56046E34D332" modified="2023-09-13" version="1">MVLGKVAHYAFDAVLISAFLAGVRRSTGLTPSVKPDNFTETPGLKKWIDNYLWVGEWTMDQSVAVFGTSGYFERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCE5</accession>
    <name>A0A9P4PCE5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="17" type="ORF">P171DRAFT_364228</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCE5"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="16">
        <location>
            <begin position="10"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="729"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2442435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="965" mass="108082" checksum="197068F20B7D2BC8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDE9</accession>
    <name>A0A9P4PDE9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_90257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDE9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="200" mass="22460" checksum="17E5787F2A8BD37C" modified="2023-09-13" version="1">MQTNVPEGRERGSRLPRGTIGSWPCQVDADLTTGIEPLQWIVWNVLDETRGQSRERRSRVWRAPDKTEDRTQRRKAVRTGRRRWAKAGGARWMDNGGRTVYETRGPVGTLCMAHCMWEGAGLTMTQFVDGILLLPRAAPNEAPCPRTRSNSNDMRRPMVRASALARPSTRPLRLFGQPSSGQGREGMGTGLEHAIAVWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDP1</accession>
    <name>A0A9P4PDP1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_487924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDP1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="193" mass="22492" checksum="54809EE98BFC77D1" modified="2023-09-13" version="1">MSESVAEYATELYVFARNHGIQLLSRRTRRWVMAVVDVKRVESIPAITFAYVKEWVGIPWDTKVELPNRLLQMCLRALTNPEEVRIVTDQHGGGKVRIYYGEYHPQDPRYSESLRVLQSLIRQSQCILWVWENKEELVRLCDWFTGREEWEWWVDAELEVMERALLGHGNAMVYFVDDGWGGPLPALVLGGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDS7</accession>
    <name>A0A9P4PDS7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_496523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDS7"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="62"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="418" mass="46715" checksum="BC0B10B67E6657E8" modified="2023-09-13" version="1">MADVTALRRHANLFRRGGGLDIPADVIISWPAPNYINPEIHSDSGPIVVIVFLALSILVYLARMWARVVTTKTAGLDDWIMTSAIIPLIAAAIAVVLACQEYGYRRHTWDQTPDILMSTRKISILSFYKRITTGSISKAFIYWTWGSIAFVIAYFFAFSLAIIFSCSPIEGYWYYYDITWRVTHELKCNDEGALTVSAVVIGTLLDFYLCALPVLLIWNVKISKRQKAALCGIFGFGLLTCLCGVMRAYYAITVYYTTYDITWYAWYGWVWTALEAQLGVMCACAPALKGFFKRYFSLNTARSNDTGRKSSSGRVPGYGKLSAGDSLATSALVEEHVRLNRIKVSTTANMVKDGDNRASIGSSESTRYLTALPMIVLPLPVHGDERATSPSIWNGNRTVITTYQEEHEFDMEKNARDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDV9</accession>
    <name>A0A9P4PDV9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_434931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDV9"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="338"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="700" mass="77273" checksum="537AA1CC4AF008A9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDW8</accession>
    <name>A0A9P4PDW8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_522969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDW8"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="357"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2442077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="515" mass="56578" checksum="8377ADD06FED86B2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PET9</accession>
    <name>A0A9P4PET9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_366166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PET9"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="79" mass="8565" checksum="9EA1DB2A23EE613B" modified="2023-09-13" version="1">MSEHNYKFEVAMSCGGCSGAVERVLKKLDGVKSYNVSLETQTAEIVTEDSLSYDTVLEKIKKTGKTVKSGTADGETRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF18</accession>
    <name>A0A9P4PF18_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_415595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF18"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="765"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="876"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="877"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2443830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1078" mass="117717" checksum="6754E0636C298707" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF28</accession>
    <name>A0A9P4PF28_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apc15p protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_45458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF28"/>
    <dbReference type="OrthoDB" id="5320532at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39552" checksum="8E7B7D35566F544A" modified="2023-09-13" version="1">MLSLPTIPPRADASLWPSLRKPHQTFDSDAPSQTHPHRRAQAHAHAHGAPTRSLFTQLLLDENKQKQRNANIRHFGATWIRPPGIQKTYQAMIDEEKEIKEQEALAMREQQMMDLAAAQQDAANAEARDAADEEIDEEERDLDDDVPEAAASGSESEVSASGSESEEGSVSGGEEEESRADVTFNEDSFIEGSMIEGRVGQMLAMEEASMEGSLLEERDLDDDVPEAGEYEHTDSSLLDSSDEDDGSFVQPGSRSARSRRSSGAVRSARSRRSSGVRSVRRTSGLVLAHPMGPTLMMGQAHAMGQAQAMGQLQAREQMRNSRFSLELEGSSSLMEGSSFLVSSPVAARGNVRARLFGARNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF55</accession>
    <name>A0A9P4PF55_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_46317</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF55"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="518"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="540"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="576"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="612"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="648"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="684"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="720"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="756"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="792"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="871" mass="96184" checksum="84D8083AE98538B7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFW1</accession>
    <name>A0A9P4PFW1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_523040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFW1"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="293" mass="32543" checksum="8D1516AD38CA50AF" modified="2023-09-13" version="1">MESTCVVPASEPASTPKKEQTKLPIFKVTKPGVKRGPRKLPKALQRPVRSAGKVSPVKIKADGLVDARDPPSYLVPAVKRNATESPLLRLDASIRKKIWEYAMGGLTIEIKARKVQTAEESAPATPTSNTGSAYYGKVSHHGPKRTQPKTAFRLPEVSRSIYEETATLGYSTNQFAFVGEVDTKFGREDGPDGALEGWCRELVPAQINAVKSIRPHWHDLQEYVNKSNMRAFKQLFPHLKQIRVPSRAVNCNAKWPCRGDPMRKHLRQQAKGRISALVKRQEGDDVEVVFSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG58</accession>
    <name>A0A9P4PG58_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_487778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG58"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2442548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="186" mass="20673" checksum="8F53C622E8512115" modified="2023-09-13" version="1">MSPPSAHTRSKGAEPENYPLKGKIGGKTSLGRPKKPFKDRTHKVTEAKIQKPTAGSRTTAKRPPAAKIEPVADTQSTAESEPVATSAHICECLGECKNEPTPVCRKFLQGKCTKKCKFAHPNDPALFERHMRLLEIEEEEKEKESAERDDTDADEKAIVVQENDGPRHACRYGSQCTNARCRFSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGE8</accession>
    <name>A0A9P4PGE8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGE8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="174" mass="18239" checksum="7137326850603E30" modified="2023-09-13" version="1">MLGSRNAGDQGRIARGAGGTRRSAATAMIRCTGTGGAGAGSRGSESLFPASNGRSFVAAGVGSAPPQNRSKSKDKLQGPPRCISLGQVAFTSRRSSLVARCTRCPHPPPTPRPSPEQQPRHAFEARDRGAAAPIGVEQLRPLRTATTTTTARLKTREPRTGLLQLPPVHQLQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGL2</accession>
    <name>A0A9P4PGL2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_280717</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGL2"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="577"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2444699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="691" mass="75489" checksum="ACC6832341555ABC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGW5</accession>
    <name>A0A9P4PGW5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGW5"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="498" mass="57311" checksum="D21FE27EF18ED95B" modified="2023-09-13" version="1">MPSLPAELWEHIFTYLECRMPIEKWWYYGEQYDVSSLRDLASLSLVCRAFHHIAQPFMYRTIPADGFQNLNKCKALLARSLIENPRLAAYARNVCLDSSSSWDVEPVEFEGLLDRGDVGEREKRWLNMTMMESSKLRRNAQLFALMRNLHVVDVSVFSDASHIAGMLSGRSDVETIVQAEANLMSETGYSYKRGKEELRKNIPSTLTNETLADNALPRLKELRIRHGDCEDGSISISDIEAVLLHPGLERLYLLGFDWSSFGLRKARWPLHPNPTLQILDLRDCLVDTQGLRNILERFESLHTLHIILGDSRRENPSFDMIEDTRDVSLTDIGAVLRKHARNLVSFELHTTGYRQCSGVEGRLRSLKEMTSLRHLKIVEHDLRVRRTRYGVSTKYDTLPLEDVLPAGLETLYLHYDDCYFGPCAPDTHLFEILGRMLRSGKVPELREIKVERYLNDSTKELKPEIEGWKVCMKEEHLWGGPTSSGCMRLVIELTRLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH51</accession>
    <name>A0A9P4PH51_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo-keto reductase family 1 member C13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_432986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH51"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="298" mass="33088" checksum="3998A14EA2BD1C35" modified="2023-09-13" version="1">MANLNVTIPALKLNDGASIPMLAYGVGTAWGKKEESKLDQAIVDGVKTAIKLGYYHLDGAESYKNETELGQGIKESGVDRSKLFVTTKVWEPTGEAGDIERALKQSLKKLQLDYVDLYLIHSPFWAKSEQDLQNTWAEMEAVQRAGLAKTIGVSNYRPQDLEAVLKTANVIPAVNQIEFHPYLQRVETLEFNKKHGIATTAYGPLTAVTKAAPGPVDDVFPGLEKKYAVSAGEISLRWCIDQDVVPITTSSKEQRLSDYLRATTFKLTPAEIKQINEAGQQKHFRGFWEKKFGAESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH89</accession>
    <name>A0A9P4PH89_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_22278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH89"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="94" mass="10560" checksum="F47469FD5A9A0523" modified="2023-09-13" version="1">MCRTHLPVQDRRSRSTPTAHIIRTPTQPCNPKVRGASRAAPPDAPKTLHPQQRVHPIPTPHYTCTRRRTARISLYPAHTHSTRNGVNTLVFIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHN5</accession>
    <name>A0A9P4PHN5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_56590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHN5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="240" mass="26620" checksum="89D0BAB4771FA1A8" modified="2023-09-13" version="1">MASARNCRRRAGDALSSYTVPIHRPHTKHLQKRMRTNDVHPPSKFPVATSPSPTLSQQPTAHLTHDFHTTQSPSSPLHLTGTYSHTPTQPPFARKTITTTFHPYTVLHLQKTTTISTSKDEAWDTTASISHRKEKTLISTTPAQQEVPVQFQSRSEQKRLEYHSNYLALEGLGVCNASIQFNSIQFNSIQFSPCTQAGLHGTLLSPIFPILLGPKSKKSKMEITVCKTAAQNSSRQGRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHX3</accession>
    <name>A0A9P4PHX3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHX3"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="229" mass="25268" checksum="C51EE2726530AEE0" modified="2023-09-13" version="1">MTNFNINIVSDTVCPWCYVGKKRLEKGIAAYKAAHPDSDDSFSTNWFPFYLNPDAPKISIDKTGFYRQKFGDQRAAAAFQMLGQVGRDEGINFKFGGKTGNTRDSHRLIQLGKTKGPQMQTRVIEELFAAYFENEKDITSHQTLLEAAEKAGLDKSEAKEWLDSGKGGAEVDKEVQDAYAQDIHGVPNFTINGQFEVGGAQEPAAFVQLFERLKRQDGGAVAIDAGSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIE7</accession>
    <name>A0A9P4PIE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_464104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIE7"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="401" mass="43811" checksum="0E1E1D6F6EDAE81E" modified="2023-09-13" version="1">MFGILRIGSEKDSVEFIEHAKGKAASQLGGYVFSHSACGGCRLKKVKPSHSSEPADNHSSRPKSTPHSQANISDTSGTSGIRNNPSALNNIGVDQEINGWEMAEIVPTTSNLNDLRQGSRFSGEPDYSKNELDDIFSTIAGLQPEDMQTNVFMLEDIGGIEASQPPSADAQSSFMDFGHARTSPSLQSHQNTDAAASDNVVTTGLSRARSSTDLSSCQCRGSILRVLAEIESKILSVSPSNMYAMLSYQRRTTAASNEILTSRICNCSKKFFGLLEIIGEKITSLSEAIIAAFVCRVKAQNDYVDFDESDSFDKCLDRNSAIRLGEFQVQTLQELKVVSAAVIKLQLKYSLTFVSRTRELAISMNLLAQAQNLEKLEHRLEKLSTKMQRTASDVESDICKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIJ3</accession>
    <name>A0A9P4PIJ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_279562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIJ3"/>
    <dbReference type="OrthoDB" id="3793221at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="179" mass="19419" checksum="9B41C139D05B19A2" modified="2023-09-13" version="1">MQKYIFKDRAGYPDVATLDSREVNIAPDGFHDDIPQEGLTFGLGPEIAAEMKKIVEENCKDRKDLQVCIEKVHDTLTNTQLNTHSKRFVLLTAGTVAAVVPWIIPVIAVVGIVAWALASEDGKPAKVYLPHEKNGPLAQIETLGDDVDYVAFSIGEGDEANVVANVTITLTPTPTPNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJK4</accession>
    <name>A0A9P4PJK4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_345523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJK4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="31"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="261" mass="28337" checksum="1B3127D5CB64DEF6" modified="2023-09-13" version="1" fragment="single">IPSSDRTRKIKTHLYTPPSGPGSRDSPKPVLVNWHGSGWTIPFHGSDVAFCARIAKELDAYVVDADYQKAPEHPFPAALEDVKDVLDWVASQPERFDATRVAVSGASAGGSLALVASSTLRASLGVNIKAVLAHYPVADLSLKAGDRVIPNPVNPLPPPILELFYSNYVGMDVAMRKDPRVSPMYARVEEYPRTVVIIACEGDSLSVEAKRLAEKVDDGSRKVVKCVLEGMNHGYDVGARPGTKLWDSREKAHALMIEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJP6</accession>
    <name>A0A9P4PJP6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_34682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJP6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="129" mass="13863" checksum="80BD1840C7CC05E1" modified="2023-09-13" version="1">MPCSGKLFAERPQRLGVVRRPNAEAGHKGAWASRAETASNKHTTSGCRYRTTVLLTLAWRGAATSETVSIVVILAYTAAHRSISSVYLRPHVAGSRPGAYLVVWLEGGIVPGVYVRALKSRLETNAGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJW0</accession>
    <name>A0A9P4PJW0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_431444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJW0"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="245"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2444643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="407" mass="46509" checksum="1560D563196B6340" modified="2023-09-13" version="1" fragment="single">MSIVRYIASFYPPLSERTPYPPLYQLLTFTLSLIPFFFHARRFVAILILPLLLTLCLRAPFYTFGDPSSNYYNTSIFVATPIWLVEFAILRPEEGGEAPVWVGRHIETEGEGVKGKGVHDMTTTWEKLSWVISLMIPSHRGMGWNWQVSRLPDHPDANLPKWQFVGRVLRKAIMAYVYSAIMLVVYGFAFALEKEILPEHTVRRFVANAIIGWSGAFWILNRMLCFYDFCAAASVALGVYDQWQWPPLVGRLQDAWSVSQMWSVVYHQTMRVMVSQPARRITRALGIPKGSMASRIMQLHISFVISCLVHEFEMFNVTRKDMGEFVFFMSQPVAITLEIWVQLAWKKATKAKGVPKSVGVWTGYVWVVVWMSISLPWYVKGMKNAGIMNDAIFGRRPLDAGASLMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK55</accession>
    <name>A0A9P4PK55_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zf-DNL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_430935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK55"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="90"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="213" mass="23199" checksum="ECDD8B2A142E0BF2" modified="2023-09-13" version="1">MPPAPSSLLRCLARPAAPRAARASLPECIPMPMSKRLFHAPRTATSTVLRPSPILARPHLPRTRVRYESTPSSNSPGTTTAAPESRLDRDQVPSYELTFTCKACTTRSSHRVSKQGYHHGTVLISCPGCKNRHLISDHMKIFSDKSVTVEDLMREKGSLVKRGTLGPGGDVEFWDDGSSSPRSAHFHPNANIKGEDDAPEGTLTEPPNPSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL22</accession>
    <name>A0A9P4PL22_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL22"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="130" mass="14021" checksum="7E903C0665E323D6" modified="2023-09-13" version="1">MARVIVRTSQWRDVSLCSGSPWSMHCAGSGCTVSPGADFKADSQSSSCKRGGELLPPYAHSIRKLPAHHALARLPTVAIPSPHSLPLLHPRQPVNPRRNQTLPSPPYTESTSPHGISTPSARRLARVHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM00</accession>
    <name>A0A9P4PM00_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_453957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19537">
        <property type="entry name" value="C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="923"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1419" mass="159367" checksum="10F54C7E34C5D490" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMA8</accession>
    <name>A0A9P4PMA8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_231112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMA8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="200" mass="21493" checksum="8812B0E7F2B89594" modified="2023-09-13" version="1">MGDVTSGGYNPLHASTEPKTEAGSSPHTYSLIRYRASMLTPVVQFSRCMLHVHLGYTASGQPNTKARLHVRTGTLLLGQRRSAACLKSGNERRNSGLQLAVLNKLLPDGFDDGSVARHGAVVSTPAAQSCGAKLWHSRSVLLVADANDGMRVWWQRAGAESSSPQLVCIETAGIKSAVRSPQDELISPSIAICRERNWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMG1</accession>
    <name>A0A9P4PMG1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_430904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMG1"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF9">
        <property type="entry name" value="PEROXIREDOXIN PRX1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2445496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="256" mass="28325" checksum="4EA3A4DD9A0E3A2D" modified="2023-09-13" version="1">MAAFLPRAAPRALRFAARPVLRTHVFHRGFATPPVAEQPRLRLGSLAPNFQAKSTHGDIDFHKYIEGSWAILFSHPADFTPVCTTELGAFAKLKGEFEKRGVKMIGLSANDLTQHDEWVSDINEVANTTVSFPIIADADRAVAYLYDMISQDDLDNIAARGIAFTIRAVFIIDPSKKIRLTMLYPASTGRNSTEVLRVIDSLQLGDKKGIATPIDWTAGEDVIVPPSVSTEDARKKFGQDNVREVKPYLRFTNVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPL1</accession>
    <name>A0A9P4PPL1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_352607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPL1"/>
    <dbReference type="OrthoDB" id="3758675at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004991">
        <property type="entry name" value="Aerolysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03318">
        <property type="entry name" value="ETX_MTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040298272" description="Jacalin-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="39940" checksum="D723CC9FFC0D541F" modified="2023-09-13" version="1">MFFNPRSLLLGSAALFLSGLANAADCANGPWTNVLYIGGQGGGEWCHTKYDAGIVVTGMEVWASKKAVRAVQLYYSDGSNSGMVGKLDDIGEHQRIDWDPSKDGISQLKTWGNGNGKYLGRVYLRLKSGGELNVGKDTDGQTTYETDVQSGIMLGAYGRGGDSIDGMGVLFLKSKVKKVTIENVNLNERMQGLNTMIIDYADHKNNQVNASDDFSFSKKQARTVTKTYTTSAALSFGITEAVEVSGELLGIGGKSTTTLSFETTLTDTSSQATADTAELTYQTSTTVPPGGKVYCRATAMSGVYKGSYDASVKIWLEDGSDFSFSQGGELDQVTWSQASSECQNDPFTDDMPTAEAPISIENLDKRAIKFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPN3</accession>
    <name>A0A9P4PPN3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynamin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_409472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPN3"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF66">
        <property type="entry name" value="INTERFERON-INDUCED GTP-BINDING PROTEIN MX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="58"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="657"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2447088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="84519" checksum="C84A74BD0EFCB64E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPS2</accession>
    <name>A0A9P4PPS2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPS2"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="251" mass="28019" checksum="725B5754E52F063F" modified="2023-09-13" version="1">MSTESTQSQACCNTPAVVSNGYQQKGEYIEVQGMKTYATGPKDAKRGILVIYDIFGFFPQTIQGADILAHTDKDHPYQVFIPDFFDGKPADISWYPPDNDEKGAKLGKFFETAAAPPKTLERIPKVIDELKKSKGVEDWGIIGFCWGGKIVNLSSFDGTLFKVAAAAHPAMVAGDDAKGVVIPYAMLPSMDEDKGEVEKWQKNIKTPNIVEWFPDQVHGFMAARGDLEQDKVKKEYERGYKLVLDFFHKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPW4</accession>
    <name>A0A9P4PPW4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_519497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPW4"/>
    <dbReference type="OrthoDB" id="3797690at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040448019" evidence="3">
        <location>
            <begin position="22"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2447208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="682" mass="76853" checksum="30C822DC9068CD31" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQZ0</accession>
    <name>A0A9P4PQZ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_517350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQZ0"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF123">
        <property type="entry name" value="RIBOSOMAL PROTEIN ARGININE N-METHYLTRANSFERASE RMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="305"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="508" mass="56698" checksum="A689B4EA2717BE72" modified="2023-09-13" version="1">MSDTESDTASSVGEILEDISEADTSTFKCLFCDEQWSRVQDMFAHCTKEHGFDVENTIKKLGQDIDELTVIKLINYLRLEAQKSIAPAEIKVDTETLADDKYLQPTLTDDALLFELGDFMPDADSKAIDYDEYEAALQKNVGGNVEKLSLDNDRDTDYFESYKGNAIHREMIEDRVRTEGYRDFIEKNAELFKGKTVLDVGCGTGILSLFCARAGAKRVLAVDNSDIANRARDNIARNGYSDKIEVIQGRIEDFHMQRKIGKEKVDIIISEWMGYGLLFEGMLDSVLRARDLYLKEDGLMVPSHCTMRIAPISDREWISDASGEKFWKDVYGFDFTSMIPGGILNQREIGVFDVPSKSIGGEASTFYQLDLKHIQIRDLDFTAPFSTKLGSSSASIDAFAIWFDTFFLPGEKSQDATAIDVAKWGDHGEAGLGFSTGPYSTYTHWHQAVLLLGDEDRKKEVKGSSTLKGKVTYKKPRKDDRGIDVTVEWEAEGAQGPVSGSSKLTMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRI8</accession>
    <name>A0A9P4PRI8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_469260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRI8"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="3">
        <location>
            <begin position="118"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="436"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="948" mass="107900" checksum="EE48E3B54DD8B19B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRM9</accession>
    <name>A0A9P4PRM9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRM9"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040482947" evidence="1">
        <location>
            <begin position="18"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="197" mass="21603" checksum="3E307ACEB6D499C1" modified="2023-09-13" version="1">MRSFATLLLGALPLTLAYPGQANSVKCAGENTLIWTPTYGTKDAVFSVCATIKIKGTVQKVSNAILDFPKYKNWNNFVVNAVPPAGVKSPSDLKIGMGISFTSVGIPAGSNNTATDYITWLEPPYFAAWKNTDYEEYIGHSEHVLLFAPLPNGYSQFTHWQTQLGAAAVNLLSTKPDFQREFTQEANDLKAYVESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS64</accession>
    <name>A0A9P4PS64_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_426742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS64"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040445016" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="324" mass="35713" checksum="F84C00A19D1912C4" modified="2023-09-13" version="1">MLHLLPLSTLLLLRAVLATPTPSSQPLPLLIWHGLGDNYAADGLHTVGDLAIATNPGTFVYYIRLDESPDSDKTATFFGNLTEQIAQVCDDLANHPILSTAPGVNALGFSQGGQFLRGFVERCNVPPVKNLVTFGSQHNGISKYQICGASDWLCKTYIGLLKANTWGAWVQSHLVPAQYFRATNDSTGEPTSDYLDYSNFLADVNNEREVKNATYKENLAGLDKFVMYVFEEDTTVIPKESGWFAHVNASSGEVTGLRDRKIYKEDWIGLRELDEKGGLEFKTTEGGHMQLSDEVLTEVFEGYFSPANGSWEGPKGQAHEQVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTV2</accession>
    <name>A0A9P4PTV2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_315371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTV2"/>
    <dbReference type="OrthoDB" id="4490227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7136" evidence="1">
        <location>
            <begin position="2"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="1">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="197" mass="21704" checksum="87DA9F748C190D94" modified="2023-09-13" version="1" fragment="single">TGVLELDLVFPRNETYAPEALFPLTFARNYSSYNPYFKYHSIRTFSGEGHWQIAWEVSYTNCSRDRMPGMSFNRTSYVLTFTTKKGAQEVDLLAPTTTKSYEERNGVALEITETMKTPLGADWYGGETCAAIAPTRPTPNPCRVSIDLDTASSISSSMERTLCKATSTPFDCEKDTDEKGAAGQLITGGVVTAFATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUH4</accession>
    <name>A0A9P4PUH4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase I-specific transcription initiation factor RRN6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_426100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUH4"/>
    <dbReference type="OrthoDB" id="4090074at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048537">
        <property type="entry name" value="RRN6_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20640">
        <property type="entry name" value="Rrn6_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="104"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 helical bundle" evidence="4">
        <location>
            <begin position="573"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="3">
        <location>
            <begin position="855"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="932"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2451599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="981" mass="109590" checksum="12511482FDA76BE8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUK0</accession>
    <name>A0A9P4PUK0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUK0"/>
    <dbReference type="OrthoDB" id="10427701at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040352050" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10420" checksum="F321090FB00A972F" modified="2023-09-13" version="1">MRASRNRGQTLTRLPLCIIRLIAIGLEADTKPHHIHPIIIATVTLCGRMGAKTDEHELQMTYQMEYHQDKVSSWAKPKEPRTCWGIKRGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVP3</accession>
    <name>A0A9P4PVP3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_196994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVP3"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="420"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="639" mass="68322" checksum="1EC35E603D154223" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVQ3</accession>
    <name>A0A9P4PVQ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_205157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVQ3"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2450108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="298" mass="31650" checksum="B890104A33235636" modified="2023-09-13" version="1">MESESGAKIAIRGKGSVKEGKGRSDAAHTSNQEEDLHCLIMADTEDKVNKAKKLIHNVIETVRTIEALIMSHTNACRRRPSPKARTSSSATSSASLPPSTVLSVTTRTKPARTVARSVTASTTVPRSKITRQASSAVSVDKLDTWLAIVPSARLDSPGATTTATETALKPGSAVPRTSSTASSTRWVVVAMVALLEQSNTMAMEAARVERNRALRSLGNSAQLARLLLGLVATSVTMIALKAHLPRRGPVPARTRTTREATEAVQVLLLGRLLAPTRLTATEAMATTNPLLRVPLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVS8</accession>
    <name>A0A9P4PVS8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ISWI chromatin-remodeling complex ATPase ISW2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_375186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVS8"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000114">
        <property type="entry name" value="DNA repair protein rad8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="261"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="657"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1127"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="113"/>
        </location>
    </feature>
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            <begin position="130"/>
            <end position="144"/>
        </location>
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            <end position="1140"/>
        </location>
    </feature>
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            <end position="1159"/>
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        <location>
            <begin position="1177"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1242" mass="140601" checksum="BA9BF05CB5F5752D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVX1</accession>
    <name>A0A9P4PVX1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_468610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3728558at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="219"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="378" mass="43653" checksum="3F0A2F6E42F76E47" modified="2023-09-13" version="1">MDRTSLPPEIQFMILKHLASGNNIAQYATSYDCSECNQYESEYEHRTTAVAVKDGIRTMFQTLRKSSHSGDMTLDLSIYSPSDAEHYFKYIRFEPANVLSRNRMREQATPRCSTQHVAMPPCCQQGLWRILFMDFDASGHETSESGGEFWASVPQVSCVTRLLLRRETRRLWDLIAISRLSAHFPNLEDLVIEPWSAGVNEIEMDTDKRWTDLVFPSLIPNNLRRMTLFEDFSEAYDPRNTLYVLEHQVYPAFGTEIAQLVDLFSDYQYTRAIRIVSARLTRALAEASLGLQHLSVAFMTDARLFWGVRRDWVWEHLQTLALTSQDLEQHNDPRKIEHVLYSAAGAVKKMPKLQTMELWNGGKGHAALFRYNSNRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW46</accession>
    <name>A0A9P4PW46_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_515399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW46"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="270"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="667" mass="74399" checksum="2C18C8CAC3531A59" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWU5</accession>
    <name>A0A9P4PWU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_10958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWU5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="82" mass="9587" checksum="00B16DB644F7CD7C" modified="2023-09-13" version="1">MRRSQQVTALILLTHWVPKYRVIFKMSGGFSQALFSWLLVVFSATTRRSHLELIPFDVPYLSQEGEHRRCSIKLWIQIGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWX4</accession>
    <name>A0A9P4PWX4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_438444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWX4"/>
    <dbReference type="OrthoDB" id="10290206at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040441583" evidence="1">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="169" mass="18325" checksum="ACE3D2E77106FAD2" modified="2023-09-13" version="1">MPLTSVKLIVLLSLLGTNAQRTIELNPRVCGPKLGRCPIGSYCAANGKASGSGICIPRFCTNGVCPLYSTCDYSGVGRAAIEGRCIQDLCNTRGKLKCPQGWICDMSNVYPYIADSPGRCTRQICGTGDYFLCPKGWECDMSRVNPNIVDDPGVCVENMVELFELEQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PY08</accession>
    <name>A0A9P4PY08_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multisynthetase complex auxiliary component p43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_347203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PY08"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000199">
        <property type="entry name" value="tRNA-aminoacylation cofactor ARC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="5">
        <location>
            <begin position="256"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2451378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="454" mass="47942" checksum="909132E6BB6748BE" modified="2023-09-13" version="1">MATATLDESLLTFLNTHAPNNASSETDAVKASQALFPSVTYTDAEKAELSKWLTSAAHVAAEGEDAAKAAERLSSLNTHLASRTTVLGGKPSVADIALYQKLAPVVSNWSAEERTGEQGYHHIVRHVDFVQNSPLFGLKLDDKVNIDLDSVIFKIKPVDAKAEKERKKKEKEAAAANAAASGGATPTTLTGDQAAGDKKSKKEKTTDKAEAAGEAIASTVAGKAGGAPEGAPTQKKEKKPKQPKPQKAPPAEKPLSPCLIDLRVGHILKAERHPNADSLYVSTIACGDPAGTDNTSEYEGQVVRTVCSGLNGLIPLEEMQNRKIVTVCNLKPVTMRGIKSCAMVLAASPKVTEGEDSHKGPVELVNPPADSKAGDRVFFEGWEGEPEAVLNPKKKVWETIQPGFTTTDSLEVGFNVEDVPQLLGEGADKKTGVAKLKTAAGLCTVTTLQGATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4E3</accession>
    <name>A0A9P4U4E3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_491713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4E3"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040265770" description="Cytochrome b561 domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="9">
        <location>
            <begin position="201"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2437854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="395" mass="42931" checksum="F38C1142B499D96C" modified="2023-09-13" version="1">MARVLIAAAVAAFAATAFAAVSTRCPLLDVCFRVESFDATRAVAGCDFLLGISAPATYNITLAHHNRERGQDDLFHVFANAGMSDLVTSRVVVGREIDNHDKACERLPSSGVKDGKMAADIRCSLCDAKSSGSMDLSTPVQSWNWTYSVTDVAGHVLDSGAVSFDSPTPPLLTQLKSRQAPAAGRAGGFKIPARTIHMAMAHGVLACTAWALVFPLGGILVRLCSFRNLVWVHTGLQIFGLCLYTAAVGLGVNLGLSPWHRWIKDKHAIIGLTVYGLFLTQAASGYIHHIMFKKYISRTTWSHIHLWTGRLCITLAMVNAGFGFQLRQQKIGSWKVVLYTVCAGLMWCAYVASIVVGEWRRNKQMKKAASSLETRPSPADSGVHMPMVREIPKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4V4</accession>
    <name>A0A9P4U4V4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetoacetate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_423520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4V4"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="122"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="702" mass="77064" checksum="6EDADB22417684E0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U570</accession>
    <name>A0A9P4U570_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_437798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U570"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3990:FF:000001">
        <property type="entry name" value="26S proteasome regulatory subunit S5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2437406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="293" mass="31093" checksum="A58DA54843F3EA8B" modified="2023-09-13" version="1">MVLEASMIIVDNSEASRNGDYVPSRWEAQADAVNLIFSAKTGANPESSVGLMSMGGSTPEILTTLTTDIGKVLDGLHRTKIKGTSHFSTGINVAALALKHRQNKSQKQRIVLFTCSPIEEEEKDLVKLSKRMKKNGISVDIIAFGELGDETTRKLEKFSEACQSAEGSYLAIIQPSSNLLSDSLITTPILGGDASSGGAGASNAGGEGGDSGGNSFEFGVDPSVDPELALALRMSYEEEKARQEKEKKSKEAADGKSELESVAEGDEKQPLLDDQGKASGSKDKKDDDKMDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5K8</accession>
    <name>A0A9P4U5K8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_448644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5K8"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="535" mass="56868" checksum="FB8536FDF0FEF88D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5P3</accession>
    <name>A0A9P4U5P3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_478182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3794420at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040441114" evidence="1">
        <location>
            <begin position="23"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="432" mass="48151" checksum="8E7F707E94E4246E" modified="2023-09-13" version="1">MAFAPLMAELGLGAAFTMIALAPMVPEWVKKPEGPKMNVKILAGSPDDNSDNTFGGAVPQIALFDVNGERLGYWRNEGGKELLGKGNTADKQVGYIKEKDNRKPEYITLTASGFEGICITSVVVFHPESSDTFAFLPGEIAAQCESVWDEHDGESLLWSNQVTNIQFQSPAGKKGTARPKCLWIDSPDENGKTTTKWKGLGTHLPDFKLDNSTYKEWERDPFQMCGSKARFGLYEKINEMMCPPVFDKAPMEGARIPMSEFPTCAPGLFPDANGNVQEDLCKDPAVHGAERKTLSDAFGLNCENFDDEDGDLHGQCPRHIRQRDPVACNGRRRSEPSRKKKENLQNRFLGKLVKSYDIRQSARELCNSKGSVGPNFYSYHEKQFCDMGKKKLFSLCEDDGQVECFDGLLNTTRHSPTKGNRSVTHDSVQDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U774</accession>
    <name>A0A9P4U774_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_500725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U774"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="237" mass="27000" checksum="2B6801DA700A420E" modified="2023-09-13" version="1">MYSTRLTRPGLDFTSLSTTTASLTPEDTRTDYLEPSYLKHNGKPLVSTFNDETISNDAWASFKSSSPAQTYPPPVAPSVRSSTGTHSPPPKQGRQKSPPQHNLSLRRPQALDSQPDMMKLQTWNDAGESHYMGNWWEDPIAGTLILEYVRDYDHKKSICRFWGLSFRRGNGGYYYREYSAERQVVQGAFWHHTLAGNGDCGSDGFGSRKPSTMRRMLLAYSCRGFWEDETCCIYKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7M1</accession>
    <name>A0A9P4U7M1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Reducing type I polyketide synthase 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_457894</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="20"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="928"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2269"/>
            <end position="2347"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="928"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1077"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="960"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2439283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="2370" mass="254787" checksum="AD8F272F98771614" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U845</accession>
    <name>A0A9P4U845_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_498652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U845"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF65">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="4">
        <location>
            <begin position="164"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="66"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2440810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="270" mass="29473" checksum="2299A0B4078890EB" modified="2023-09-13" version="1">MATWIVKNMLRNTSEASRVSKILASVRTERSADRLRHELRDHSKRIDIRVQDNVGVASASDMIMLACKPYQVQKLLAAQGLAEALHTKGIISILAGITPRQIRETLTKDRADGNYDIIRAGPNVGARVGECMTVISEPHDVSTKLVEDTTWLFEQIGRVTEVVETAYDSAFVMVGSAYSLPTVAIEGLIDGAVQQGLSRAAATDITVQCLKGLTKMLENGDQAADIRNSICTPNSVTIAGYLELERRAVRAAFADSLRVAIERTKSYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U891</accession>
    <name>A0A9P4U891_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_367605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U891"/>
    <dbReference type="OrthoDB" id="5377599at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="94"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="234" mass="25777" checksum="F4EF6B877C92F62A" modified="2023-09-13" version="1" fragment="single">EHMPPIRRKGKMKEGGPASISGTRTADPGAPPKESIMTAPIVDSATSPTFLSPGKTPPRKVLRLKCAKCHEHPEGFRSEHELRRHTNRVHRKTRKVWITIDTSPDKTFLANCKACQTGKRYNECYNAASHLRRMHFHPHKRGERKMSAAEARRGGKPGDLDPPMDVLKANWLREVEEVVGEAEDSPEEGEPVDASSTQLQPAVAQADGKAPPTPATPSMRTMAIDSIVDKIDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8B2</accession>
    <name>A0A9P4U8B2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_487372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8B2"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="194" mass="21659" checksum="4C453EC6715FCC87" modified="2023-09-13" version="1">MTSTNALKAPGDSAMSSAMTRAITVRNQTVSPLLRLPGEIRNKIYAYASHNNALYVNTRSGRLQNHENSRGLIFACRQTLAEAKQICMEEVVLQFPPGKGLFIFRKRVPASTLAPIRRISFPMEVTRLILDCHDHTNAASVIGSRLVSLDTVFVCAYWDSRIPNDQARREIITDRLVKVTGNQSLKVVFGLCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U910</accession>
    <name>A0A9P4U910_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_446572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U910"/>
    <dbReference type="OrthoDB" id="5139943at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="418" mass="47134" checksum="EA4F8F57DAD51797" modified="2023-09-13" version="1">MAHLSGLPVELLQRIAGFLNCSSALHLARVSRKLHNACNHRVVFRDIALYSLAHDFNDPRAETLLWPEGYDILKSVSLSDTVRVACAVERAVERAVGRAGGPYEPVWIAKANSADSRDVVCPDIDEWLPQLLAWHHPSCKYMLDTSLLPAHLQLGKRLDYRNRATFINVGFCLAYFALQNVSSMSGDVYTPFEIEDSIAKMSTEYMFSLCWGLKPPDVNQSFSSFDPVQGSTCIIPFLYSVLGSGLFGRIPLPVPSRIPFSSFMDIPWVFKDSAEAFARCHVQKMTEPDFLTGTWMGYYTDQRLVNHRHFALVGPPMNDINIVAEPSGEPSNRSEPKGHIHCSQSSGFDSYGPFTICGDFHHDGRVEFVKHYTQLLWDWQYSGIVIPFGIVGRWSDLEGNFGGHFWIWKKDWCDSQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9P1</accession>
    <name>A0A9P4U9P1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NPD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_434949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9P1"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="358" mass="37468" checksum="63F0FDB67EED2406" modified="2023-09-13" version="1">MEGARQLREDYPWIHTPLVVGAPMRLIALADMAVEISKAGGLGFIGVGTDTSTLCSDLQAAAKLIDKSSIKTGHSVMPIGVGFINWGADLSTAIPLIAQYQPAAVWFFAPTSMSSLSKWTTQTRNASPRTKVWVQIGSVKEAVEAMQAARPDVLVVQGTDAGGHGLAQGASLITLLPEVSDNVSPKCGEGRYPQPILIAAGGIADARGVAAALALGAPGVVLGTRFLASPEANISKGYRDEILRANDGGQSTARSKIYDNLRGIAGWAETHNARGVINKSYVDAMAGMDEEENQKLYEEEVKKGDAGWGVEARMTTYAGSGVGLVRDVKPAGDIVREVREGSRAVLEGLSGGAVVGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA75</accession>
    <name>A0A9P4UA75_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_455854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA75"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="7">
        <location>
            <begin position="12"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2442925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="182" mass="20731" checksum="7857EF6B9666B1E6" modified="2023-09-13" version="1">MAGKNSIWNRKKDLVYLVFFLTHIPVMLAFDLTSYYPVAVKPSWMTDVRTWYVATYGDRFFYNAPPWFSTFTLLELLYHLPLSFWAIPALIRNDPRIPLALLVFALETSITTVTCLAEMLSWDELTPVQRGVQGLGGMYGAYLGSDNANCNKGIFMAVDCYARLDQILSKQKGIKPITKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA83</accession>
    <name>A0A9P4UA83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_486920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA83"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040226009" evidence="2">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="104" mass="11558" checksum="FC9EF85430B9ABDC" modified="2023-09-13" version="1">MLDLFVTLPLATFKQLASALLDVNRTSPKPTDTLAIKDTHTRRQSRIQTPVTKPTHTLRQSLTQTRASKPTDALTSKPTNTLAIENTNTTLSHPTAVHHKRLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAK7</accession>
    <name>A0A9P4UAK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_523166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAK7"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF2">
        <property type="entry name" value="HYPOTHETICAL POLYSACCHARIDE DEACETYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="129" mass="14909" checksum="B76D02FE5D71A67A" modified="2023-09-13" version="1">MHPTPSFLELPKSSLVEIPCNGYMEDMIPLQFFSNVPNSAGYVDVRVVERMWMDGFEWLVKEVERGRKDMVGYSMVIHPDTSGMAHVIGMVERFLRWILSFGEEVVEFRTCGSIAEFRRREGEKGVEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAS8</accession>
    <name>A0A9P4UAS8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_473673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAS8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2443376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="424" mass="47548" checksum="0DD890296A5456E7" modified="2023-09-13" version="1">MAFHRPNTTQVPNPDPHPPKLNIPTYQEGPYVSIAPHEVAIADIQAYRIIHRIGSNFNKGPWYTSQAPSQYNDETCGVFGILSNKTASRRRRLFQAAGTKNIVAEWEPQFIKLFDLALQRIKADLQDGQYNFVKWWTFLASDVTGGLAFGEPFSNLKNGVISAMVQDIEAAMPIIGVRAELPWLKPVLNYTPTWCGNTWSARFDRFVGYGWDAVHATLDDEEEQAVPDNVIVSEAANVIVAGTNTAAMTLTYLTYAVLKNETVKKKLVAEVSKLLTDPRWNELENSPYLNNVIQEALKLHPGVPASLLRIVPTSGSQVDKHVIPAGTQICTRAWNFQCDPYVFEDPLRFNPDRWNNPTPAMKEHMMAFGAPARMCLGHNIARLEILHAVSKLFRECPQTALHPSTTEASMEMVDYFAIKPKAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAU7</accession>
    <name>A0A9P4UAU7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_71093</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1065"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="289"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1328"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1328"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1346"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2442628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1423" mass="152354" checksum="E36AE25B7BA5331A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBE9</accession>
    <name>A0A9P4UBE9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_432135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBE9"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22676">
        <property type="entry name" value="FHA_SNIP1_DDL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="381"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="483" mass="55980" checksum="566B7335887A5554" modified="2023-09-13" version="1">MPERELSPYSARVALTQKLQQGPGNQSAPPVEHKSRPWDTRGPAPPQRRQDGFGQSSMPHRGMGRDGRLSPPTDRGRERKDKSRSPPPTSVRDRSPAERLQKAKPKDVSVEPALVARNREASPEPYRKPREASRERERKRDRSRQRDPPKDRHSRRDRDRSKDRDTVKDRDISRERERTKGRDRSRESHRSKDKERSRERDRSKGRDRSSDRHREKRRERSTERRRDSSRERKRSRDRGGRRDRSRSQNRDRHRRRSRSPCSERTSKRRRKHSPSPSRSPSPHPRSKRALPDQEVSFRGSDNSALPPTKYGGAPVNLEKPNFKPTGLLAKAANKVEGTKISLKYHEPPEARKPPPSQAWRIVVFKGDDVVDSIELGSKSCWLLGREAKVVDYVLEHPSSSGQHAVVQFRYVTKTVEDEYGVKKTRGKVKPYLIDLESSNGTVLNGERVETSRYLELRDKDILKFAGSEREYVVVLPPPEEPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBN2</accession>
    <name>A0A9P4UBN2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_389097</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBN2"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05522">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromatin structure-remodeling complex subunit RSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000048">
        <property type="entry name" value="RSC complex subunit (RSC1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048047">
        <property type="entry name" value="RSC1/2_bromodom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="48"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="258"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="11">
        <location>
            <begin position="371"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="537"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2444395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="885" mass="100257" checksum="B71E38ABF990535E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDR1</accession>
    <name>A0A9P4UDR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_431049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDR1"/>
    <dbReference type="OrthoDB" id="4790878at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="129" mass="14852" checksum="C62399756161AA4D" modified="2023-09-13" version="1">MDPASPLLKLPGEIRNRIYALVATDDEPVKIRHLGTIRQTEKEDEVEDVNDVEHVEGNCAGLTRVGRQIREEYLPIYRQHAVVVMPAPQVDQWLMIFNEAHPIKGFMVNVSFTWDGTDDFSAQVKWDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDW6</accession>
    <name>A0A9P4UDW6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_357633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDW6"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="77"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="386" mass="44471" checksum="6D2E849DDF2740BB" modified="2023-09-13" version="1" fragment="single">MQELCSQVRKTEITTKSQSNVILLTLEKWFEDHENAKLQRQCLQALYFPRLDSRENDVKDAHTKTFGWILEDSQPGSSLSQQSNFKQWLQSQDQAANVFWVSGKPGSGKSTLMKYLKDQPRLCEHLGTWLGDSTLIIVECFFWRHGDRVQRSIDGLLRSLLYHILKKCPKLVPTAFPNPEWLLGGSSYQFSRKALVDAFNRIINTLSDERLRLFIMIDGLDEFDDKEEHGSTSYDQHHLVDLLSMFCGKDLIKLCVSSRPLPIFEQEFGQDPARRICVQNLTANDIRIYVKEELENNPAFQKLVENDRSYAVLIDEIVDAAHGVFLWVHLAVRSLLRGITNEDGISSLRARLRLLPPELNDLFKHILNSIDPTYRKTSALMLLAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDX8</accession>
    <name>A0A9P4UDX8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IdgA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_520388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDX8"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
        <property type="entry name" value="YeiC_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="7">
        <location>
            <begin position="432"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="7">
        <location>
            <begin position="725"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="786" mass="83088" checksum="A164BFCE2F93DECF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE29</accession>
    <name>A0A9P4UE29_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE29"/>
    <dbReference type="OrthoDB" id="5213630at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="188" mass="22187" checksum="A229859ADD595D1F" modified="2023-09-13" version="1">MEYSEQEYLQAMDQAENRRIRQEETIRSLQHQLKHEKQQVASVKQLADQIHMEKDSSMVMFAPQPMDSNVCEDFSSLLDDIRTWSTKFSCDTGRMSDFKSDNTSNYHQVVPLCNDAAGIVSFMDQYRNDQSLDEKSRKQLDKMRKRHFVRGRASFVMIERCFQSSDIWLRTAYLEAVHRIERVLSETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE32</accession>
    <name>A0A9P4UE32_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE32"/>
    <dbReference type="OrthoDB" id="3945200at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040273060" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="70668" checksum="E077FFCE1DB3010B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE33</accession>
    <name>A0A9P4UE33_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_213403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE33"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF31">
        <property type="entry name" value="HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="373"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="524"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="819"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="984" mass="108978" checksum="11652B3AD0735CCA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UED5</accession>
    <name>A0A9P4UED5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_406981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UED5"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="294" mass="31997" checksum="884B75BA455AA680" modified="2023-09-13" version="1">MAHPRSLLAPLGRITAPSIASARPSLPRLAALPLYQTSIRCKTTKAPDARKRKARKHYLQSDLRKADQFSLVDAMHYIRAFEVGRGATSSKYEMHVRFRTLKNGPSVRNRLRLPHPVKTDLRICVIAPPDSKAAADARAAGASLVGEEEIFAKIKEGQIEFDRCLCHMDSLQKMNKAALGRVLGPKGLMPSTKTGTVVTNVGAAVKSMVGASEYRERDAVVRLAVGQLGFTPEEMQTNIKAFMETLKKDIARLNGTPKEIHEVVLSSTNAPGFTLNGEFKGADSVSARVLSGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHC2</accession>
    <name>A0A9P4UHC2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_427402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHC2"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18246" checksum="F2367136E091DF83" modified="2023-09-13" version="1">MRDGPGKTALKQKALKVLQQRKMYDAQRDQLQQQSWNMEQAGMMQDNLKNTMTTVDAMKTTTKELKKQYGKINIDKIEQLQDEMADLMDVGNDIQESISRSYEVPEDVDEAELDAELEALGEDVELEGIGESSSTPAFLLDDAGPPQFIDEPPEHGKVKEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHH9</accession>
    <name>A0A9P4UHH9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_427769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHH9"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000010">
        <property type="entry name" value="EH domain binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="12">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="248"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="355"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="537"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2449588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="575" mass="63992" checksum="3BADF9417C230D3D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ95</accession>
    <name>A0A9P4UJ95_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_316318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ95"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="65"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="351" mass="39743" checksum="4A41F466DEAF635E" modified="2023-09-13" version="1" fragment="single">MSTLEAHNHISPDSGKPTVLHPNFNPKIRNWNPTDPIREEITPPKDRAHFADPDKKRLLSVATATDLTEGIGTLLEGVQLSQLDGEQLDDLALLVAERGVVFLRAQDLTTETQVKLFEHYGILDKHPAQKDAQHVIIKGSAGDWRQDAAYTPWPQAGWHADTSFEVNPPSYSLLRMEAHPEVGGDTAWVSQYGLFDALSPTYQKLFESLHAVHTSRLQYDTILDLWGVGPNRPPIDTHHPAVRTHPVTRLKAWNVNEGFVTGFAELKKVESDKLLDFANYHIHSADDQLVRWKWDVGSVAMWDNRAVIHRVIPGRYQQGSRRGVRTTVFGEKPFLDPNSETRDERERRVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4U5</accession>
    <name>A0A9P4P4U5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_478115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4U5"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="29"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="433" mass="46056" checksum="EEF3E51B282472BD" modified="2023-09-13" version="1">MPPTLNSQTASTLHAHIDNATSGPNPTLPGAIVQILDARGTELFTHTSHKHTPKTLFSIHSCSKLIGAIAFMQLVDAGLATLDDASLIEKWLPELAAKKVLTGVKDAADGTKEHVFEDRKGAITARMLLDHTNGTGNTFFNVELRDFLGEGAATENEGTAYYDTLLKSPLLYQPGTKTNYGQGLDWISVLVERLAGKSFEDVLREGVFDPLGITHGGFRGEMGGSVVSSTPGVDFWPASLRLGDGDGGFMSIPGFAEKKVERGDAWPAGKHHMQSVATGLVLSVADLGRIYSVLLPQNAGVDPVTGTRILSAASAAEFAKVVHPVEIRNDSRNIPAANPVFLPYELQAPNVDPAGCFGLGSAIQGDDRVLVDGRRGRSKGSVYWVGAANVAFWIDGAKGVVVVAAGNFFPFMDGKWLEFVEGLEGLLYEGIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P560</accession>
    <name>A0A9P4P560_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_182678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P560"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000013">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="515"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2437442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="578" mass="63168" checksum="76FCC0F687FBDEA7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5S3</accession>
    <name>A0A9P4P5S3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_525979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5S3"/>
    <dbReference type="OrthoDB" id="4140442at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="285" mass="32501" checksum="7DEA3F1C168A843F" modified="2023-09-13" version="1">MAACSRGVTSFLHPHAFRLPSTLRATLLNTRLQATRAHPPTRQFSASIIHRYAAPTHSSTSSYVQNDPVLRSVGQTKEAVLLYKEPPRQKYLAKVYSWATVTTGIGLYNFYWVSALPPGLSFFVAPTYVVIGIAFCAIGIHLYQRPVRRLATLEVVPGYRGGRLQLRLTGRKEPWSKDQVIETDIFNATISEKTVPMLKEMVEAERARRQNIKQGLEHMSILPKIWEIMARWVEQKWTSFFLRFKFAVLQFGIIHVEVDGVKWKIDCEGYLREQGAAVDRILPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P635</accession>
    <name>A0A9P4P635_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_459206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P635"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04401">
        <property type="entry name" value="RhoGAP_fMSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="42"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="982" mass="107437" checksum="787C242AC23E1185" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6K2</accession>
    <name>A0A9P4P6K2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyisourate hydrolase</fullName>
            <ecNumber evidence="5">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_436012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="5"/>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6K2"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2439314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="162" mass="17666" checksum="C3BE3CE6E0CE9C8B" modified="2023-09-13" version="1">MPHPSSQAAQRIEAVSAHLSPNPPPPTMSTEKKPPITCHVLDTSLGRPAASIPVTLTLHNPPSSLSQSGLTFTGTTNSDGRVTSWTPSSPFSADGLDVIFKRAGDQRYSLTFDTESYFGERDVKTFFPEVEVKFVVRDDAKAEHYHVPVLLSPFGYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6P8</accession>
    <name>A0A9P4P6P8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_504659</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6P8"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="24"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2438481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="433" mass="46843" checksum="7FF3AE343BCA96CA" modified="2023-09-13" version="1" fragment="single">IGILAEIEDRPTPPSVYNWRVYVSAATASFASCMVGYTTSFIGTIVSLQSFKDEFGLSSLSVSQSSLIQANIVSLFQAGAFFGSIFAYSTAYHLGRRITLWTFVIMFIVGACVAFAAIGGHIGPMYAGRVISGFGVGGCTMIMSRVVPIYISEIAPPAIRGRLVGSYELGWQIGGLVGFWINYGMTQSLPYGRNQWLIPFAVQLIPAGIVLIGSLIFLCESPRWLWTRGRREEGVATLCWLRKLQPDDTYFFEEIEMMDLQIQGLPSGFLKPIRLAVTDSKVTWRLFLGHMLFVLQNFSGINAINYYSPAIFETMGVTSIKTVDLMTGLFGGVKCIMTILWPTVLIDKLGRRTLFLVGGTVGAACMFVIGALIASNSSSSTTDSSLSSQSIAISFSSTSGPVSTSPPGTAHRGSSTPRCSARRAATWGRSARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P763</accession>
    <name>A0A9P4P763_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_478002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P763"/>
    <dbReference type="OrthoDB" id="5398388at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="106"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="242" mass="26660" checksum="0901ED8E23A630D3" modified="2023-09-13" version="1">MSGTPQTTSTPPDAPIPSPSTTTLVSVIIVFLDLATITLGLRVYCARISARDKWFTVDLMLIIAALIVTYGCILTTIMGAATLGLDYTNNKMDPVQGAQLLFEIQFFSTNPISSAWHPERQLVDLNHDYPTALLAIFDIGIVLDFPVLCPSLRPIWQLQLLLANKIEVSLILWLGNFCVGASSVRFYYSYRQFNVVFVTTAQEKGTIAVQSSLWSRIERAAPSLLHSCPPMAGYSRTAAWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7B9</accession>
    <name>A0A9P4P7B9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_437139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7B9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="58" mass="6975" checksum="FCE7CC882EA0CABC" modified="2023-09-13" version="1">MAMMTAQRQLSPMLAVQAFSTAIDGRRVYQRQHICSRNVEHSNEGMYRYIKRHHYHHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7L2</accession>
    <name>A0A9P4P7L2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">P171DRAFT_476298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7L2"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="257"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="659"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="713"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="770"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2439885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="979" mass="106543" checksum="A0FA599D44FD72B3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7L4</accession>
    <name>A0A9P4P7L4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_155455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7L4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="201" mass="22318" checksum="826499559C2565FE" modified="2023-09-13" version="1">MDANVLSARAVIVPGSSFSRSSRATSQKTEWCRQVRQGGCMLIRRHWHGGRAATGVLVRLASGSWYVYQAPLTCRTCVVPRRKLLGTYCGETTPSIRSNRPVNTLTRCPPPLQLQDVPPMNRAIWIYIIVAVANTGSQARHGVASRKFPPREVRPLASTLEAADDHMKGPRRNAHTAGCIDKLHALGWARRGPRRESWSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7W2</accession>
    <name>A0A9P4P7W2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_423701</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7W2"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00443">
        <property type="entry name" value="ADA_AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000033">
        <property type="entry name" value="Adenosine deaminase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2438478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="348" mass="39137" checksum="BA81E15FF935BBFB" modified="2023-09-13" version="1">MANAPPVDLPFARRLPKVELHAHLTGSISRACLHAIWETRRQQDPDLQLDDPLVAIPPGKVDYHVQTFFPLFSSYIYKLCDDLPSIVFSTRRVLEDFQADGVVYVELRTTPRAIPSRDITKDDYVKTILDVLREHNEQKSNTMRAFLILSIDRRNTAAEAQEVVDLALKYRNGGVVGVDLCGNPAKGDVSLYTDAFNRVKAAGLKITLHFAEIADSGTDDELNTLLSWQPDRLGHVIHVNSSFQERIKKENIGVELCMSCNVHAKLITGTFSDHHFGFWRDTSVPVALCTDDVGVFCSPLSQEYYLAATHFGLDRAQLIELAQRPIASIFTGASERRRLESTFKHWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7W6</accession>
    <name>A0A9P4P7W6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_436320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7W6"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="274"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="316" mass="34551" checksum="8A0BFBAAB834EF67" modified="2023-09-13" version="1">MPDTTKVVPLTCHGHSRPVPHIHFSALQDEEQYYIISACKDGNPMLRDGLTGDWIGTFLGHKGAVWQARLSSDASLAATASADFSAKVWDTHTGEALHTLTHDHIVRAVAFPNQPQPQILATGGKEKKMRIFDLNNPSQPYEIGAGVHGDTIKSIVWTADPSILVTASEDKRIRWWDLRTQSTIGEYAVEGPVGTCELDNTTSDGVLSVAAGNSVYFFNGNSPASLIKSIKTPYELASVALHSGQRRFVTGGSNQNDTWVRVWDFDAETELETNKGHHGPIWSASFSPDGKLYATGSEDGTVKLWKFTNGPYGLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8B4</accession>
    <name>A0A9P4P8B4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_436436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8B4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="84" mass="9400" checksum="2D403A0A2226855F" modified="2023-09-13" version="1">MSWLVSLPVSRKRRLLTTMVCGLWCSLAVHRTERCCMPEAWFAISDDSCGPQWDAGGRALLKAVVVLVLTVMKSRRTYSLPANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8L7</accession>
    <name>A0A9P4P8L7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_367702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8L7"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040150600" evidence="4">
        <location>
            <begin position="18"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="24"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2440439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="345" mass="38321" checksum="99679D3155C867F7" modified="2023-09-13" version="1" fragment="single">MFSRSVALGLLASTVSAFDASASNNVAMYWGQGSNQISLKELCNDPSVDIVNLAFVNQFPKKRGEYPATNFANACDDIFYKDDFGNESGLRSSCPTIIQGMQTCRDNGKKVLLSIGGGYPTDYYLKTRDIAEYLADFLWGAFGPPDAQWTGPRPFGNQYVDGFDLDLEAYMTPEPFTGYLSANYEHLVNRWKNVLFPTKAGNFYISGAPQCVVPDVRLSDAISRSHFDFIFVQFYNTPLCNARRAYEGVSASNGVVTTFTFDTWVTWLKQHSTVNPNVKLYLGLPADKGAAPNDQTSYLEPSEANTVLKYYKNKYPSVFGGVMLWEATFNAKNTCNGPTYATNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8P0</accession>
    <name>A0A9P4P8P0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_435267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8P0"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="109" mass="12643" checksum="4EDFA64CDB201461" modified="2023-09-13" version="1">MAQSLTPMEDVMRAKLTEAFKPTTLEIHNDSHLHSHHKAMQGVTSKETHFRVLITSEKFKEARMQPARHRMVYALLKDELAQEGGIHALQLKTRTPEEDERQQQKEQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8Q4</accession>
    <name>A0A9P4P8Q4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_436048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8Q4"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="674" mass="75641" checksum="E270AE9CAA57E0F6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P931</accession>
    <name>A0A9P4P931_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_435441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P931"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="886"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="890"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1154" mass="129966" checksum="8E47B9668F47E851" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P990</accession>
    <name>A0A9P4P990_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_490617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P990"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040367851" evidence="1">
        <location>
            <begin position="18"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="233" mass="23337" checksum="75C9C55B33193A35" modified="2023-09-13" version="1">MVQTSFITLLLPALAFAAPWGGHWAPASSVAATTEVAASSSEVPAVTVTSAPASSAAYSTAVAEPTSTSSPSTGGSGGKVTLKNNCDYDVTYEQLCPCGSSDGSGTISAGSTWSDSISDCAGGNTALKVYSASTSKPMQFEYGLQSGNIWYDMSFIDCISGSDDFSQCAGSAWSIGAVGTCQTYACSGGSECCIQGYCDPTASAAAVQPAFGCGAFQGYSVSEVGISIELCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P997</accession>
    <name>A0A9P4P997_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lysine-specific demethylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_490862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P997"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lysine-specific demethylase-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="105" mass="11713" checksum="A089752C850A2EBF" modified="2023-09-13" version="1">MAPKYMSVLIEQSIELGIPEKHPEMHSLQDKKVQGELWESKAKELIDIKGAKRAREKANADRNIARGAVKLKSEDDDDLVYTKTKRTVEEACACARTVADTSTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9Z6</accession>
    <name>A0A9P4P9Z6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9Z6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="115" mass="12606" checksum="08688DED5C46D67A" modified="2023-09-13" version="1">MTFPFVPLPPTPPDRAVHIASSASPFPSHPIPRGSTPRYLPLDLDSTPRHHISPITQQRSNFHGGREGEGEGGGCLALPVPRTPPPPPWGFVSRGTLAFFVFDMLRYAMLCYAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB96</accession>
    <name>A0A9P4PB96_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_465554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB96"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="7">
        <location>
            <begin position="756"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2440851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1037" mass="117329" checksum="6883EA3DBCBDD6DA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBE1</accession>
    <name>A0A9P4PBE1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_114711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBE1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="309" mass="35434" checksum="3F6104226737FDEF" modified="2023-09-13" version="1">MAELVMVQNQSSKLVLLENSMELAQKFLKLALDAIKERIYARTTISMGYTKESIWQAAYEQMSPTASVSSFLPIYLFTKMTVASMQNFVRDSWLTYLSIRHLQMGENIRRWRGLLCAVLDMLETDLHSSQRDRELRMQTLSTTWHIHEWATTHVAENNQDLVIEVIARLLCHFQQSTVNVATPDGKALWAFSATAHVYFHLLESISHVAKNSGGVSIRMLDDHPWDPLTDDLSKMEQWVRHARQSQVCRLYAGIPTVSRPRLLAQGGTYGGRHHRNQGLGAEVRSALPSTLRETVQRRLRQILSSWWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCG9</accession>
    <name>A0A9P4PCG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_101350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCG9"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002838">
        <property type="entry name" value="Uncharacterized ATPase YjoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="228"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="540" mass="61501" checksum="BE7C1CDD03C283D5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCK7</accession>
    <name>A0A9P4PCK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_446470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCK7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="178" mass="19491" checksum="1A63162BBDDE6FCF" modified="2023-09-13" version="1">MSGGLYFVTSAMLAAAQEAQAAQSHAILQPQKLVVVVAEWPGEGGAGVVQDIGTRRRQLMSCAIAFAAPEVSKVQASVIDEESEFAEHVNHPTVSMFQELFNSSHLTLRDILSGTRMHQYIAYSAALERTLHVSLVTNHNNPTKGPLVSRDIEQLRVLRFAFTDIVAADRAIRHQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDC0</accession>
    <name>A0A9P4PDC0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_88955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDC0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="218" mass="23568" checksum="A7E3361ADA58383E" modified="2023-09-13" version="1">MKPISYLNNGDILTLHMHRISDVNDSPCTHQDGLSRSIPHPRCIKPGDLTHPSCIASHRIASPRTHRALIRSPSSHHTASLPCTTTTTTTAIDKPSHTQSNPRPHTRADGSAVLTHSTHHVPGRTPWPAFPFPPSLPPSPPTTPTYALSSRTPPSPCWPNSTRNRGAHARARGQGCQGELASASFTGEGWPIPTVRNLPALGLANQRARRPWGRGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDI9</accession>
    <name>A0A9P4PDI9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_419194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDI9"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF5">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="47"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="345" mass="38415" checksum="E6003F7192CDA849" modified="2023-09-13" version="1">MVSDYILLALHIFRVLPEFAATIIRQRISNFFHGRSYKALPDDHVKNVVVIGGSFGGYQAVKRLTETLPTGYRVVLVEKNSHLNYVFAFPRFSVVTGNEQDAFIPYSGLSKGALEGIFHHVQDTAMDVTERFVELKNGEKFEYEYLVIATGTSSRLPSKVASTESRDAQQELRGMQEKIQHAERIAIVGGGAVGVELASDIKDFYPDKDVTLVHSRAQLLNSFGSRLHNHIVKTLTDMGVTLQLNVRPKFSSQTNVLKFANGEEKEYDLVLLDDRFPHIFAFGDVAATGGPKMGRAALFQAEIVIENIRKLIKRSKSLSTYKPNIALEGAIKLTLGKVSLRRVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEP6</accession>
    <name>A0A9P4PEP6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="14">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_433171</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="14"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEP6"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040433457" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="18"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2442756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="400" mass="43964" checksum="4FB0847D4DBA8C94" modified="2023-09-13" version="1">MLLTWTLLTLFAVPALGGMNKTGTLCTVTPSGSKDDSGSIMDAFKQCGQNGQIEITEGDFTIAKVMDVLNLKNCDISIKGKLTWNDDINYWTKNSIGVSYAQRSTAFRLGGDTFSIRGHQKALFFGNGQKWYDVNRNGSNMAGRPISLTLWKAKNVFIDGITWRQPQFWHTFVAYSENVTMTNLDMNATSTSQWNTVNTDGFDSWNSKDITIKNWVVKCGDDCISIKGNSSNVYVKNVTCYESGAACIGSLGNNAIDYVDNILFEDFTAIHSSNAAWIKTYPGQGHVRNVTFRNFNFQDVNQPIYISPCIYSYSNCDASRLKISDITWENVTGTSRYNVAAGIYCSKGAPCTGLKFKDINIKPKNGGTAKVLCSNMNSDSGLSCTGTCPSGWKQQLSGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF57</accession>
    <name>A0A9P4PF57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_433225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
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                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Mondo S."/>
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                <person name="Goodwin S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Culley D."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
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                <person name="Lipzen A."/>
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                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <dbReference type="Pfam" id="PF25289"/>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Henrissat B."/>
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                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="485" mass="57261" checksum="8D6DA1C706E0755E" modified="2023-09-13" version="1">MPALDLKNHMHRCIRLPPIPKVKLGLETTVHFSPGVTLRSYSLFTVGSQAVANQTAMPLIQALKPDPTPTSQNQEPEPLDSTLLLKAASTPNTHKDKALAKFVVDINSPDISHDHYAKAIEDYITGAVYRRDDSTKVIDDYVMSEHQRLQRIANQQDKTSLEQSIKSIQNLIILADNSLRKDKYCLDDLATLTKAIQEYYMNKDPRLDDAIDTKLLEKCFEGTKHILRRVANHDAREDWTPSLPWHLPSHISLYATGPCLICWHEWDCLGGSEVQPYESTHGMNTNPDPEVDPGVIPDRSAYGKGPERLCVVCWNTPGGCELCKWCSPPSHWTFEEQRRQEGQRRQEEQRRREEERKKIKRKEKKRQRKQNKQRRQEEQRQEEQRQEEQRQEEQRQEEQRQEEQRQEEQRQEEQWQEEQWQEEQWQEEQWQEEQWQEEEQRQEQRRQEEQKKHAKTAPTWAEIFDWQRTDEGLPDEFLGTGYGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGL7</accession>
    <name>A0A9P4PGL7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_39888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGL7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="84" mass="9771" checksum="D15EA6940214C478" modified="2023-09-13" version="1">MRDVRYSQWLTWVVCSGRNLHCRGRSCIEWRHVLDRIRRAHGGRGNWIACITFNSISLDVQPPRICRINLPQHHPPSQAFGPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI02</accession>
    <name>A0A9P4PI02_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 131 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_430832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI02"/>
    <dbReference type="OrthoDB" id="5283326at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF4">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040159671" evidence="1">
        <location>
            <begin position="16"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="223" mass="25342" checksum="5C94A49D20F09A65" modified="2023-09-13" version="1">MWKHLFTANFALALATPQLYRRDPVQCPIIFDGRVSQNSTPVSFNIADVSPYSTQYVKGENLTWSQIIFLPNTTTSRFDTLGVHRSLEVTINDHSLFRSGQRLQYGFRRAGLLLKDDKNAAGADAADQGVVTFHWSVRQDVSKPMNLSHEYMNVWHEKADYSGNQFTFVGGVVLPVDAAPAIDAPEEKNAWRIQNAKNEFLFRTPIRNDAWQNFAVQLDYTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJQ5</accession>
    <name>A0A9P4PJQ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_485350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJQ5"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="264" mass="29424" checksum="70AB58B014AF7041" modified="2023-09-13" version="1">MSHLHHKCTQCDRTFAKLDSLWAHFHLEHPTSSRYSCPVCNRLFLTATHLDEHAGYSAAAPSDKVIHAHYCSGHGCGKRFCSFQARDMHESACKFLPKESKIEDNEDKYAAEGDKTVAKTMKKTEHRELFRAVLEADKVIEFVPVAGRSSNTVFPGEQPATGTMHKKETGYTRSTKKRKGKATAHPAQANNLAHKSRSEANTSNYLDAGAPSFTGGVVDLDNWFADIANDPRYALCSWTNCGNCGRCMEGLYPDSHQETYYAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJY9</accession>
    <name>A0A9P4PJY9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_430619</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJY9"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000003">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2446470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="359" mass="39221" checksum="BCC8B7F7397F61B2" modified="2023-09-13" version="1">MSPANQAPPSNATDAVLRPSEPVPADAREVQGIEFNDYAQRSITVEELMGGYARMGFQATAIGEAVRIVNDMRTWKDTETGDGTTIFLGYTSNLISSGLRETLRYLVQHKHVSAIVTTAGGVEEDFIKCLGPTYLGAFSTPGASLRAKGLNRIGNLLVPNNNYCAFEDWVLPILDKMLVEQEESKKTDEPMHWTPSKVISRLGKEINDERSVYYWAWKNDIPVFCPALTDGSLGDMLYFHTFKSSPEQLRIDIVEDIRKINTVAVRAKRTGMIILGGGIVKHHIANANLMRNGAESAVYINTAQEFDGSDAGARPDEAVSWGKIKADGDSVKVYAEATVAFPLIVAATFAKGRPDSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJZ5</accession>
    <name>A0A9P4PJZ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_30920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJZ5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="133" mass="15273" checksum="D9670CD58663B717" modified="2023-09-13" version="1">MRRWLTRRGHLGACCCGRRDADSSPAAAHRRWRRACSVDKLMVPKEQRAYHAHAPERSTACRCRLPRYHTRIHDRQISRPCTAQLGCLCHSAMEASLSSHHEHMPASNQQPPRCPKPPIAQMPPSWLHGWCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKN0</accession>
    <name>A0A9P4PKN0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_510840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKN0"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="285" mass="32527" checksum="9323599A29379835" modified="2023-09-13" version="1">MTSRIRENSNNVSLRNTSRRAVMDQDPETDPRASASPPGPRDTAVKMKLNISYPNNGTQKLIEIEDERKLRVFMERRMGHEVPGDSVGDEFKGYIFRITGGNDKQGFPMKQGVMHPTRVRLLLADGHSCYRPRRTGERKRKSVRGCIVGMDLSVLALSIVKKGDADIPGVTDTVHPKRLGPKRATKLRRFFGLSKDDDVRKFVIRREVQPKKEGAKPYTKAPKIQRLVTPQRLQHKRHRVALKRRRAEASKDAANDYAQILHKRINEAKSAHDEAKKRRASSMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLB6</accession>
    <name>A0A9P4PLB6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II transcription factor SIII subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_430822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLB6"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33994" checksum="88ECCBE328AE0ED8" modified="2023-09-13" version="1">MPVPTLFHLAKKRLVQNIHQLDDIGDLPYAFLAPILRQIQIPDQLVQLEANCPQIQGETGEIWLRLIKRDIPGWDKKPHQPQDPKSWSKVYKKLKKEAAAEEEAQQAALKQRMQALQKDRNGHQTTIINASLNLPSARRSGWSFGGGARSGWGDPAAPKKTGKVAFDKLKRGIYDAKRARPKASMTPQHVLNETKRTVTQVPARMVRMAEAEALSQAPRRKLVPKAPPAPVAGANTTRRPIIRQQPMPRINDAAPERAERPRLPAGQQFSAPRPVPKPQPVSSGPSLKRTRAGPNILVESKRRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM29</accession>
    <name>A0A9P4PM29_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 transcription factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_472173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM29"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2445394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="632" mass="70880" checksum="824A3584228FACD8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMT2</accession>
    <name>A0A9P4PMT2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">XTP/dITP diphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_384868</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="11"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMT2"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2446158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="191" mass="20945" checksum="EA3F349AF155DADC" modified="2023-09-13" version="1" fragment="single">MGSPAAVPKHLNFITGNKNKLAEVQAILEGVIELKNQNIDLVEIQGTVEEVTTDKCRRAAEAINGPVLVEDTCLCFKAMNDLPGPYIKWFMLALGPAKLHHMLDGFDDKSAQAVCTFAYCEGPGHEPVLFQGRTDGKLVASRGPTVFGWDSCFEYEGTTYAEMDKSEKNKISHRGKALDKLKAWLASKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN05</accession>
    <name>A0A9P4PN05_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 1</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_430451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN05"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2446263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="246" mass="26949" checksum="45267FF772071FCF" modified="2023-09-13" version="1">MSSNRARRIAKELAEIQNDRLSQITAEPAGAGDDLTHLRGSFPGPPDTPYESGTYNVDIKIPSDYPFRPPVMRFETKIWHPNVSSVTGAICLDTLSTQWSPVLTIKSALISLQSLLSTPEPKDPQDHEVASMLIRNPSEFAHVAREWAVKYAGAPKREIAEGSGGATAESLRKKSQDAKANEAKVALAAYHGYNKDLVDRFIAMGFDVEAVVSSFEYVGIDRNGGEDYELEEAYMGDITARLFGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNH3</accession>
    <name>A0A9P4PNH3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_462512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNH3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="529" mass="59946" checksum="04217D4C5B1A42E1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNW5</accession>
    <name>A0A9P4PNW5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_482783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNW5"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="99" mass="10992" checksum="E616315EEE5ABC75" modified="2023-09-13" version="1">MFAVVILAAKHPMRLPKLELKTLTLILNKAPPNNYHAAAIEKEGGFRTDLKPINITQPEGVSFSLGGHRRRADAYVARIGREESPALEHIEQCSFRVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNZ0</accession>
    <name>A0A9P4PNZ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNZ0"/>
    <dbReference type="OrthoDB" id="5291209at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="346" mass="38621" checksum="5F84DFCCA4D266DB" modified="2023-09-13" version="1">MGVHHPHQTDAVDANNTPSRAVTRAYSQTYQTYQYHLFVVAFVASLYGLYYQISNVYREYATRHSKHHQHDMYFSSSIPSTSSALASSETKYTRSVFLPYVHKFGTRGVPLVWVTIHSGKQHVRIDMPVDTGSTGLLIGAPLLPGIDPNAGTRGRQYLSSSNIVYVGRYLDLNLTFHGIGDVVAEARVPVLIVDKSWVCPWYDPLKHGFECPLGPEGQEPVERDVSGITYMGVGFGRNKNAEGQRTATSWGNPFLNIDSLNGTRLGPEDMKAGYIVSTRGIQLGLTRENTRGYNFMRLERGIAHAADARDWAMPRMRFRVNGRKSIPGSALIDTGRRSSMCRDIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP89</accession>
    <name>A0A9P4PP89_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_482938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP89"/>
    <dbReference type="OrthoDB" id="3729788at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="131" mass="15049" checksum="5E4F75BF5301EC4E" modified="2023-09-13" version="1">MYDHIIEGRRQGLASKQIEIEIKISATSATSRWHALEQQNRVPEDVLDIGRRKEEVAWCEENEETILKAWKEGQDDEKVAKSVTLEGRNEGDIRERLVALRFERGPGYKRVMDMEGKRSPDALKQALSGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPF9</accession>
    <name>A0A9P4PPF9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_453874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPF9"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30896" checksum="30183C3590D580DE" modified="2023-09-13" version="1">MYLRDVHAEKHKPTLYQFIKENPLGLLTTALDSKTFQFLQSSHVPWVLDTPEGEDTTKSGTLRGHIARANPQAKSIIEAAKEAQDGQTNTDGSYCLTRDVLVMFNGPAHHYVTPKFYTETKPATGKVVPTWNYSAVQVYGRATIFYETKADSTHAFLDKQIRDLTNHNEVETMGNKEKPWVVEDAPESYVEILKKAIVGIQIEISDIGGKWKMSQELPVGDQGGVVNGFAKLDTELGKEMSETVKARTTLALREVKLTPSGISRTTMHRASASTATISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPX0</accession>
    <name>A0A9P4PPX0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPX0"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF46">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="345" mass="37733" checksum="BEA53437E8E2918C" modified="2023-09-13" version="1">MDIIRSLLSYLIPSLAPTAPTPITLRGHTGRYPTGTDHDYTFTLPDGRTLGYAQYGSLSGKPVFFFHGLPACRIEGVYLHEVALKHGARIIALDRAGLGLSSPHPGRKLLDYPKDVEALAEHLRLEKYAVMGASGGGPSVLACAYLLPATHLVATSLICCIGPSNLIGHHGGAWAHKLGFPYGWRHAPVPLLAYAMKSFLLGPVGRVDLPAENRVRKMLAPSFLAKHDPRDRTIMTDEDALWTMCAAADSAYGRSFEGAAQDGAITCGDWGFRIRDIRGDLPVMMWYGKYDMNVPVSHGDYIAAELGMRHREGKGVLDYRVSEDTHTSVFFNMKEEALRAVLGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQC2</accession>
    <name>A0A9P4PQC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_452180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQC2"/>
    <dbReference type="OrthoDB" id="3599883at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="305" mass="33521" checksum="B152FF5C52AD6F9D" modified="2023-09-13" version="1">MATHTRQASHTKRPLPAHARPSKPAPLFKRSNSYGASKKAVPLHNKDEELDDEDLMATSFLQFCTTCEKQIIVPCNSVLYCSESCRKKDTEKQFVFPPDQSPPLTPFSQLSNFSFEDLHFRDIVPPRSPTQLRSNRSSCAFSDLSSDDNAVSGDEKPRQHSDASRYLRHCQLTTYSDAAATVRTRRPHYSRASTSHVNYSAAPSLSHTPASSISYSLPYTPSTRPLPPRTNPSSSYTHKSIDLVTPLTYASTAPSSPRQYSLKSHAETATSASTIEGEILYAKTPIASMSPANGSLGRLLASSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRC2</accession>
    <name>A0A9P4PRC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_482643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRC2"/>
    <dbReference type="OrthoDB" id="10473518at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="164" mass="19092" checksum="BA5689DAEC32C405" modified="2023-09-13" version="1">MQFARCGEEWKVLAEQTLYSGFEFKIKRCAFGVLMPPKMHIPNIRLLHVYLDVYGEAAVLRRLLEGLRDNRLGFWVKRMVVAVERLYRDVGEEVKEVLGQQWELCARRGRVCFVRPLRSSRKRFDDGITLEAVEKARACLEELEVLAKKNIKFSPALIGDTKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRI3</accession>
    <name>A0A9P4PRI3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_220189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRI3"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF33">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="630" mass="69868" checksum="DC91CD3A6D3DB328" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRL7</accession>
    <name>A0A9P4PRL7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_186737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRL7"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="263" mass="29696" checksum="29D539837C4280B7" modified="2023-09-13" version="1">MTRAKNIAAHKIDKSIWHLQDSDRVLKRGPNVKVTESDALRFIASSTQVPVPEVLGAYEKDGYGHIFMSRVIGTPLHDVLHILDEVQIQTVTEQLSGFVKSWMHLRSDFFGSIGFKACRDVFFQHLPATNMPEREYGPFRSRTEYCEGLIDALQNSRPGGQFDTNDAHLIERIRGLGEGPAVFCHGDLTPDNILVDDQLNVVAVLDMGVSGFSIHEREYFEAKSRARNPVWSSMIDRIIPKIPGDIYVLLSELERELVRYSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRP0</accession>
    <name>A0A9P4PRP0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_352101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the wetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRP0"/>
    <dbReference type="OrthoDB" id="2575228at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
        <property type="entry name" value="DEVELOPMENTAL REGULATORY PROTEIN WETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2450070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="516" mass="55211" checksum="8FC8279DD688272C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSJ2</accession>
    <name>A0A9P4PSJ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSJ2"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39064" checksum="53B6737552A72EB1" modified="2023-09-13" version="1">MPADRVGRKTKTKTPSDVPQVGDPDRKRVLNVLAQRRYRERRKAKFATLQAQAQGAKSTTASSATPDSVNESHGMQNPNAFDQSEKLPNVSTVPGSLIDETEVIEEIIRDAMPQEESGFDLTGGFGQEVFDFGAQLLEDISFGLPASSLTSRSRGNTPGLTSSSSPSSSSSIDLLNPDGSLLEVPILATIRAFTTIANMLDIMDKVWNPGFTHTLPPIAPPGLPPNLHPTTAQMTIPHHPFLDALPWPSVREKLICMFSLPSMFRPPVAQDDEEEGISKAIMRLVTDLDDYRDGVRIHGNLVGWEASSELAEEAWEIGEAFYRNWWWCLDGKIIGITNRRRRERGLEPLIKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSK3</accession>
    <name>A0A9P4PSK3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cutinase</fullName>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_452156</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSK3"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2448184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="106" mass="10655" checksum="0ACD12F368CF3166" modified="2023-09-13" version="1">MTNLISQTASRCPSTKIVLSSYSQGAQVVHNAAQRTSAANAAKVAAVVVFGDPKGGQSLGSIASSKVLTICHSGDNICEGGASITPAHLNHQNDVGTAGAFVTGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSQ4</accession>
    <name>A0A9P4PSQ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_517200</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSQ4"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040504047" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2449502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="521" mass="57424" checksum="C59554A922792C0E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSQ8</accession>
    <name>A0A9P4PSQ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_481624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSQ8"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="393" mass="42297" checksum="840FF36CFC8BD582" modified="2023-09-13" version="1">MADQPPPLTGIRVLEFAGLAPGPFAGMLLADYGATVLRLDRPSPTPHPTSDQLTRRKTSITVNLKSSSAIALVKKLLPNVDVVIDPFRPGVLEKLGLSPQDVMLKINPRLIVGRMTGFRRDGKYSMMAGHDINYIAVSGVLSLFGRKGEKPYPPGNVVGDFAGGGTMCFLGILLALLAREKSGNGQVVEANMVDGSAVLATMPRLGLKTEVWKRERGTNMLDGGAPYYDTYKTKDGNGAIEPQFYAALLKGLGLKPLDLPGDRDNRADWVKLTDFFTKVFKKKTRAEWESIFDGTDACCTPVITNAELEAQGFDQRPAVTLRSTPGYAIQEGDSGRPAAVGQDIGIEGSGWDEKGLVPGAGGEETLGRWLGWMKGRQYDIESGGLVLKDSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT55</accession>
    <name>A0A9P4PT55_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ap4A phosphorylase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_428443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT55"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="142"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27672" checksum="C901E48D35087E08" modified="2023-09-13" version="1" fragment="single">LEFRICPAFSRKPHSIGEKLDPTYTNLPQWGPGSDLFCPDPRMKLAKLNGTHDLAFNMFCVDRPQFLLLTLDSYRRQSELLDASDFQAALDMLAIPGIGSELYVIFNGGQEAGCSRVHKHLQGLRGPPPAFGNFVDEGRRGSVPFRFFAHHFAEGFAGVRGERVVGVYLGLIERAKEALGLPGSASVCPHGLFMWRDWLVVIPRRRSGIEGTKASAATAGMLGSVWLSDEGPVEDWVRLGLRDVLGQLGVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT62</accession>
    <name>A0A9P4PT62_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_353869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT62"/>
    <dbReference type="OrthoDB" id="417125at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="1">
        <location>
            <begin position="56"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="320" mass="35849" checksum="FD4738E23B031765" modified="2023-09-13" version="1" fragment="single">KGWSNPAADAYFKTQPKVANEINERFFYGKMQGIAQEMHQRTGFSFAIPKGFGDDPAILDMCMAPGGFLTTAMTMNSSAQALGISLPVSDGGDKVLIPEIRGASYKFLDINMLAVDMGVNDIPLGHPDVEKFLPQQFDPNDTFNLVICDGQVLRNQERAAYREHHEAFRLTAAQLAIGLEHLRPGGTMIIILHKVEMPKSVGLLYTFNKFSSVQLCKPENHHTRRSSFYMVVKDVQSQHPEALSAIAAWKRQWKAATFGTDYEFAEALRAEYFDVEKVLKDFGPDLLRMGREVWAIQARGLSTAPWMKEQAETQGQESVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUI2</accession>
    <name>A0A9P4PUI2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_516937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUI2"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF6">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2449174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="625" mass="69193" checksum="8A715D86A37534B8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV28</accession>
    <name>A0A9P4PV28_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_380053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV28"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF58">
        <property type="entry name" value="LOW AFFINITY HEME TRANSPORTER STR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="643" mass="70354" checksum="5E1B153145EA48B2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV35</accession>
    <name>A0A9P4PV35_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor Pcc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_468347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV35"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000011">
        <property type="entry name" value="Transcription factor Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="105" mass="11320" checksum="94E7FF61FB8B7FF8" modified="2023-09-13" version="1" fragment="single">MAKKESAPQDFPCTLTLSIPFPTAHLAHTASRALSVDAELSPLVRRSFSTTTASPSESADETILRVDYAATTNRMLRVAVNGFFESLGVVLGVMRELDVDVVHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV93</accession>
    <name>A0A9P4PV93_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_16514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV93"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF6">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="286" mass="32147" checksum="E46382463DBFAC12" modified="2023-09-13" version="1">MSKLRIAMFNTDTPVPTVRSKWSTYGKMFEGLLVAAASRFTPGLAIETDEYDIQRFQYPYSLADIDVILITGSAAASYDADEWIRRLDDYVLDVYKNHRHVRMFGSCFGHQLICQSLLREYGVRVEKDPNGYELGVKELLLNKRFCETLGNGSVFSRKTPDSLRVQMIHGDHVVVPALESLPDSWIILGATQHCAMQGMYDPARIFTLQGHFEFDRFVNTELMKVFGAKGKWSSQMIQDGLEAVDADDDAEFIGEIVLQFMLEKGGSEGAAHRKIGGLLTPPFGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVB3</accession>
    <name>A0A9P4PVB3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_17606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVB3"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="11"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2452049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="309" mass="34272" checksum="ECFC892522594275" modified="2023-09-13" version="1">MAIKKTLVYGAVVNVVTLIIYFIYLCIAVWLSIRQGLGHNFPWICMIILSLCRLTQVALDLAATVIFPETKLTNTTLETGVAILTEISLTPLFMSTANMLNMTSGPKGRRMQWVLLLLYIPLIISLILIVAGGIDPASRDSPTFAATPSTKAGIVLYCVCFAILIWATTIIAARLYLASSLEVKILTTVVLSLPFFLVDVVYMMCFAFERESTHMRFNVISGDVTIQLCMQVIMEYIIVGLYLGLGLKIPDKAAKLKEIVLGDRDYDQLRETFLWKMYEAGSATVAIIVMPGLRFAHWMLGRILRAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW20</accession>
    <name>A0A9P4PW20_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">YAF9</name>
        <name evidence="11" type="ORF">P171DRAFT_402755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW20"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="YEATS" evidence="10">
        <location>
            <begin position="120"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2450388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="297" mass="33154" checksum="91F443C73E99E2C3" modified="2023-09-13" version="1">MAEVAPPPETIAEDDLCPICHLVFYSPVRTTCAHILCRACMAQWAAASQTVPMHPSSLDMDMRDFDPDYDPSYDLEARCPMCRTPTTTQADVALARVLEAKYPQTYAERRSEEEVARLAVSGEGVEHVAILMGNRHKLVGGRDEPGNRHDWTFFVRLSRPDLVSHVKVNLHPTFNPPSLVLRDPPFEVRRLGWGYFSISATVVLKEGWEWIGGSEVRGELSDRKGALGLEWMLDFEGGGNQGRVRAGVRRVGGYADEAADSGVESPLREPSPVEEGSPVRDVSPVRWPHMDAEDWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWB3</accession>
    <name>A0A9P4PWB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_380526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWB3"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="416" mass="45683" checksum="4CC35E08C42BC34B" modified="2023-09-13" version="1">MAVKAVVPFLVAMMLLTGVCNTLLTKYQDMQCVKNCDAPSKKYREHFEQPVLQTLQMFIGESGCWLVIGVFSAWQRFKSRRAGYEAIPEGAATPASDGSDTPDVSNPLLPAHPDDEGRVALTGTNVLLLALPACCDIAGTTLMNVGLLFVAASIYQMTRGALVLFVGLFSVWFLKRHLGLYKWFALFVVVFGVMIVGLAGAITRDDKATPSHAALAETAMSILRREETAMTAPSQAAMTIIGVLLIAGAQIFTATQFVLEERIMEKYSMEPIKVVGWEGVFGFLVTLLIMVILHFAIGTGYFNAREGLYQMTHFPAIAISSILIMISIGGFNFFGLSVTRTVSATSRSTIDTCRTLFIWVVSLGLGWETFKWLQVLGFALLVYGTFVFNDLVRPPLKSCVERKPEPLLPEEPIEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWU1</accession>
    <name>A0A9P4PWU1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-protein ligase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_348179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWU1"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16616">
        <property type="entry name" value="mRING-HC-C4C4_Asi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="920" mass="101816" checksum="E35F1360D7375292" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX82</accession>
    <name>A0A9P4PX82_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_349547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX82"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000409">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000511">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="505" mass="55901" checksum="8B54B2BE8BE32F63" modified="2023-09-13" version="1">MLEDVERTPTKTSDEVDYESEFTEREQRKIIHRVDRRLVVTVGVLYCISLMDRTNLSSAAIAGMNLELMLVLPFPAGSTVSRYSVVTLVFFTTYIFFQPPSTVLIRKFGPRLHLSVITTAWGAVMIGMGFVKDWQALAGLRVVLGILEAGFFPSCVYLLSTWYTRFDVGKRYSVFYMLGSLASACAGILAYGLMQLGGKASSCAVPPCKGRAGLTGWRWIFIIEGALTCALGLGSYVALVDFPDKAHKSWKFLNEREAKFIIARVDRDRGDAKPQPFSASKFFRAGLDLKIWGYAMSVLTLALIFFNTTTVTYALAYFLPIILREKMKFSVAASQCLVAPPYALAAMLMYATGWVGDKYRIRGPIIIFNMLLCLIGLPIMGFHKKASVQYFGVFLTTAGANSNIPAAMSYQANNIRGQWKRAFCSATLVGFGGIGGIAGGLVFRTQDSPNYRPGIYACIASSILTIIIVGLLTLKFQRSNAKAERGEVELEYDDENDQRGFRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX83</accession>
    <name>A0A9P4PX83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stem cell self-renewal protein Piwi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_376416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX83"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="319" mass="35853" checksum="04039F2CDAFF07DA" modified="2023-09-13" version="1" fragment="single">MASNLALKVNMKYGGDTHHLPKAELEALLGATDIETTAVFGADVAHPPVGGREGAPSVACLVGSVDAEFMSYRGTMRLQAGRQEKIHDMRSMVKELLMIWKDKNNGQLPTSILFYRDGVSESQFVHCRDYEIVEILEAYRDLIGKDKEHDKSLKLTFVVVGKRHNTRFYAKEAAHSYVNGNLKPGLLVEDVVTDPSPYNFYLQSHQAIKGTARSAHYHVLRDDMQLGSAKLPSITHLLCFAFGRATKGVSYVAPAYMADRLCDRGQVYLRPWNDVAKEPAPRFQLSNNDKKNLSKEEINTKKQKFAEKLQRRLVRDVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXI5</accession>
    <name>A0A9P4PXI5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_347721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXI5"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2452057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="56925" checksum="B8B3452070C33E90" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZI8</accession>
    <name>A0A9P4PZI8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_11415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZI8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="92" mass="10383" checksum="BB8FCBBD612B4BC0" modified="2023-09-13" version="1">MPRARPQRVYCGADHDDIRFSRSQCLTAVIPSVARSERDERTRTSRNALQRLQHELHSIWARASTLKQLQCCFVSGILVLQGCPVGKTMEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4K5</accession>
    <name>A0A9P4U4K5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADPH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_437140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4K5"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="55"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="442" mass="48539" checksum="9D1BD28553E926DF" modified="2023-09-13" version="1">MTTTQHAHHGLAKTVEGEDHLINRPAPGISYFTPLQDPPAGTALGMKDGSEKIPKIFQPLKIRGLELQNRIFVSPLCQYSSEYGHMTDWHLAHIGGIVQRGPGLTFIEATAVVPEGRITPQDAGLWQDSQIKPMARVVEFAHSQNQKIAIQLAHAGRKASTVAPWLSMGDIATESMDGWPNNVYGPSALAYNDRHPQPKEMTKQDIETFKAAFKGAVERSVKAGFDAIEIHNAHGYLLHSFLSPASNKRTDEYGGSFENRIRLTLEVVEVVRATMPDTMPLFLRVSADDWLQEAGIEGWTIDQTVRLAEILATKGVDVLDVSSAGLHEKQKIKGGPGYQEPFAKAVKDKVGDKLLVSTVGSITNGEQANGFLEKDNLDVVFAGRMFQKNPALVWAWADDLGVEGRWANQIRWGFGGRGSKSGPKTKTSNEAEFQEHKKQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U567</accession>
    <name>A0A9P4U567_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_437348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U567"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="548"/>
            <end position="549"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2437720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="617" mass="67093" checksum="241FD0806BF4E5EC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6G3</accession>
    <name>A0A9P4U6G3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_490498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6G3"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="556" mass="62425" checksum="B516E68ABC3A9FB1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6W3</accession>
    <name>A0A9P4U6W3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_491221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6W3"/>
    <dbReference type="OrthoDB" id="3796798at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="504" mass="53942" checksum="99BF93BC377A0663" modified="2023-09-13" version="1">MGLGTDAPAGYCTEGYGSFRCADPINCTAITGEVSCCEYSREVVESKLSRGGCGFRLNEASRTCLTSITCSPLSTHYMAILPISRSHLPNPSFIVAPHVSTRVDSTVRETQTQTATQEATAPTTTSSATIYTAATPLTLTAASPSVSITVSSPTLTTAIATVSPRSSTTSLSFDDVQGHKPMEGSTIGGTIVGVIAGGSLLILVLYLLFRRWKTRRANCNPKIRGVLAGPRIPTGSTVPASVYRRDGSDGWHTLPKSESSHPGGGDLEASVEQHDVGLQYYSESAHSQIDGQASSRRTAKERSSAIVEDNLTPSGSPARQSLAPISPPWSAENESSTLHSRRSNATIHWPLPKSTVSSPALLMNAREPPTISPLSPLSPFGDYDTVKAEVEEHIEKEQHRQDAYKKLSGEISDAALTKKPGSVSRARQNMTAAHEAPKKPGSVARARQNIEAARGATEQPRREIGARQNMGALRDFIRELDAQCGDEEINETGTVIRRKSKRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6Y0</accession>
    <name>A0A9P4U6Y0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_436556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6Y0"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="435"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2439236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="797" mass="88377" checksum="D8AD325F8B16242D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U775</accession>
    <name>A0A9P4U775_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="9" type="ORF">P171DRAFT_436150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U775"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="339" mass="37793" checksum="6570E8A82BE38547" modified="2023-09-13" version="1">MRPILLSGHERALTQVKYNPDGDIIFSVSKDHVVCAWYSHNGERLGTYHGHQGALWTVDVDPTSTLLATGGADNTMRLWEVKSGKLLKTWDFATSIKRVEFSADGRQLLGVTEKRSGHLGMIYVYEINPDIEAQQSDEHVLRIVCEDSKPTVAGFSYLAHYIIAGHEDGSVSQFDAKNGELLYNTQVHEADALITDLQWSQDRTYFITASKDKTAKISAADSIEVLKTYVADTPLNSAAITPIKDYVILGGGQAAMDVTTTSARQGKFEARFYHKIFMEEIGRVRGHFGPLNYVAVHPQGTGYCSGGEDGYVRVHHFDKGYFDFMYEVEREKAQELANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U862</accession>
    <name>A0A9P4U862_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_446824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U862"/>
    <dbReference type="OrthoDB" id="10543261at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="196" mass="22435" checksum="385010A726CFC078" modified="2023-09-13" version="1">MGFLSKLKSAFGSKSRQTPKQRNVTCPAERMKQENPEHFTHMRSAHTVPPVRHWTQSREVDYLDYWRGCDEIDIPTSEHAEYLDYWHDFDGTHIAASDDLDHCTYDISEAGGVPSNTPVGIDLFGPRKRGYQSSHVEELVNFELKRSNALRKKPSPSVVYAEYATVDRSVSEPAARLFSWMLHADEPFPSFEDIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U899</accession>
    <name>A0A9P4U899_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_476354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U899"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="223" mass="25709" checksum="A76A53C8AF816843" modified="2023-09-13" version="1" fragment="single">MFWFLPRARTAMALPADPSVPLPNGRCMLLELPAELRLEIWKLALTPAPRALTYRTILDEEYRVVRSGLSSMRLDDVSQRPTYTSPLEAYKDPLKVFTKPSQVRYLCKQIFSESKDIPLNLNSFTFSSSSRPTVGFAMKHFEQLIQSPPARNMWSSIRVVTIRCEKLRGLVEKTTSDDPDSQLSKPKEIFENRHIPFYTRKFLRQNPQTTLRICVPELGTEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8N1</accession>
    <name>A0A9P4U8N1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_394752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8N1"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="74"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="341"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="621"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="894"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2440363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="951" mass="107211" checksum="78FDB4317F102442" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8Y1</accession>
    <name>A0A9P4U8Y1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_489345</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8Y1"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF131">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040419775" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2440648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="265" mass="29538" checksum="37917E4763FF4CCA" modified="2023-09-13" version="1">MESRKLLAAVLFLWLGSVGAASLNETHNLELRALSIADIPPCGLACLFKTVPPTGCALTDYDCQCQNAELAQTLSACMLSNCTMHDSLSTAKVQQDICNFSDESRQHDNYVYTITCYTIPTIFVLLRMIGRPVALRFAFDDYIVVVVLFLTAVPLGLVLKMAGIGFGQHLWNIQPGQLLENLRFFYVAWTTYTFVLGLTKISLTLFYYEVFPSGGACMDSLTLLGWIVINTMVLVFLTIFNCNPVRVFWDRDIKNAKCLNINAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U963</accession>
    <name>A0A9P4U963_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_75757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U963"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="99" mass="10931" checksum="E34D9B479E19E9B8" modified="2023-09-13" version="1">MCIAACLSTHCSFDHQSTPLARITNPRPVRKLVKDGDMDETSKSGRKLPIVITRAFAQELHDCMIRPWEPRIVAFAAAPAERLSTRGCGRASVLAWLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U967</accession>
    <name>A0A9P4U967_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_393097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U967"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="181"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2441666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="360" mass="39996" checksum="12DC61ECE318BE4B" modified="2023-09-13" version="1">MNVTTRMLEIEGNDGKGYHPFQILFARMSITVVCSSWYMWWAKTKDFPFGTREVRWLLVARGFFGFFGVFGMYYSLLYLPLADATVITFLAPSLACWACSFLINEPFTRMEQIAAYVSLFGVVLIARPVTLFTSLSRNNDPVPPASGDSDVEFIPANGTDPAHRFGSSYDNVTPAQRASAVGIAMLGVIGAAGAYTTIRWIGRRAHPLLSVNYFATWCTLVSIVMMLALPDVGFLLPQSWIDFAYLIFLGVCGFIMQFLLAAGLQYEKSSRATNMVYVQMLFALSFDKLVFGTTPSALSIVGSSLILGSAIYVATHKEAPKKEERGSGEEERGLMDVEGDAERVDYDYDNDNEIQMRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9A9</accession>
    <name>A0A9P4U9A9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_456942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9A9"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="269" mass="29911" checksum="B282D880A6D86D0A" modified="2023-09-13" version="1">MANETFLARLCEQAERYDEMVTFMKIGGELTVDERNLLSVAYKNVVGTRRASWRIISSIEQKEESKGSDKHVSTIREYRKKIEEELEKVCQDVLNVLDDSLIPKAESGESKVFYHKMKGDYHRYLAEFASGEKRKIAATAAHEAYKTATDVAQTELTPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDSLSEESYRDSTLIMQLLRDNLTLWTSSDGAEGEAAGDAAPKEEAKPAEEAAKPAEAAATTEEQPPAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9R6</accession>
    <name>A0A9P4U9R6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_455566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9R6"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000266">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040547565" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="41"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2443719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="588" mass="62952" checksum="67870F9585FD9053" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBQ8</accession>
    <name>A0A9P4UBQ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_358202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBQ8"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2445864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="148" mass="16558" checksum="D848895AC0283632" modified="2023-09-13" version="1">MPTRLSNTRKHRGHVSAGHGRVGKHRKHPGGRGMAGGQHHHRTNIDKYHPGYFGKVGMRYFHKTQQKFWKPVVNLDKLWSLIPVEKRDAYLAKKSDKAPVIDLLSLGYSKVLGKGRLPAVPIIVRARYVSAEAEKKIKEAGGVVQLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCK4</accession>
    <name>A0A9P4UCK4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_482888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCK4"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="234"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="708" mass="79162" checksum="81BE124E0076DC5B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCR3</accession>
    <name>A0A9P4UCR3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_462296</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCR3"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="226"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="540" mass="58602" checksum="03C0A3812CE7B6D9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCS5</accession>
    <name>A0A9P4UCS5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCS5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="96" mass="10794" checksum="12EC9EC94576D9DC" modified="2023-09-13" version="1">MPPTIPLHRNAAAGWLASFPFLPSRLLPRPTAWHVRPIYGRHPHDHRARNLSPHAPQTPSALVAQEPSSMHASTVWINWVPERLFAGQFLQLAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD97</accession>
    <name>A0A9P4UD97_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_276446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD97"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF127">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="691"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="748" mass="81449" checksum="E08671E103A4ED60" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDZ8</accession>
    <name>A0A9P4UDZ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_519221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDZ8"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="320" mass="36515" checksum="17C322803A51618E" modified="2023-09-13" version="1">MVTLNVRSKRQSNRASCTFIRKQWTCLILSTDQPIERSIDLANHTEAFFWAVGQQLSGVRRKFRSVSEEIASLAIPSDEFLFNEAYRDSLIFEDASYSNSKTYFWALQSLRTVNDSISHLIAAWESFETCNLSDFLNGQNEKDSIAQQQPAGNNISFLEHINEEIVKLKKVQTLNLERQEEIESLRDGLFNASTVLEARTTVLQGRNIELLTYISMVFLPASFVTSVFGMDILISSVDIRDFAIIFVAVCGMTYATILLFRLANPFRHSTGSWSKGDEDKDHGTNTSRGPFDWRSRKPFRWRQNAGDRIAHADLETNKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE40</accession>
    <name>A0A9P4UE40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_430300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE40"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF14">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="23"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="3">
        <location>
            <begin position="422"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="539" mass="60735" checksum="845C358BCFA4C487" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE42</accession>
    <name>A0A9P4UE42_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE42"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF7">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="254" mass="27319" checksum="740397E5337AEF59" modified="2023-09-13" version="1">MKVLLIGATGNVGLRLVASLLTHGHKVVAHVRSAQKLESLLPESVYRQLSVIEGSAFDANAIKIAILENECDAVVNSAGLAAVTPWGKSDLPQIVAAIVEGARQAGVERKKPLRAWFLGGMSATQFPGTNSLLSDHIPILLDHGRNLALLKALPPNTLDWSMLCPSNMNPESSDFSVPTKSSHARLTASAQTPPLWKDSWLRHIPLMGKVLVIAMNMSRYGTTLEQNADFIANDLETLESPYIGTQVGIIDASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF94</accession>
    <name>A0A9P4UF94_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_427925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF94"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="360" mass="40637" checksum="D2680D8F1BD044CF" modified="2023-09-13" version="1" fragment="single">MPPAAQPRLNPTLKSNVRAELLKPWRPPKTRPKLTRTTAYKTTQYTHERHQSRYTHNPSQTHSWILLSPAPCLHTSSSTQSCFFSIPPRSAAALLSLRLVCKTWNSTICTSRTIRRVTWHAEYLLPTGTEWPPSAGIRGGLYAPTLRVTSERAVYHYFDAEAPRRELVALEPNPVFRRHLGVVSDQPVCLLQDGIAVEISSAFWATMHASRPSTPSWHIEIQRKGARRYKYVLTSADGPILVGDVVCVLNKLRQRHAIVPGAGDVEPWEGLAFPGTYTKEGHMAPEQIPNRYGHLGMGICYNRMGADLIVTDYKMWRTGRNLFVLNRPDFTGPGPWRYEHIACEVEAEDWSEGFDILFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHG3</accession>
    <name>A0A9P4UHG3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_480623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHG3"/>
    <dbReference type="OrthoDB" id="3650389at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="540" mass="59089" checksum="691F48726033E2E4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHS6</accession>
    <name>A0A9P4UHS6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_480002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHS6"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="433" mass="48277" checksum="BCA6112EAB5B0236" modified="2023-09-13" version="1">MTASAQVVQYLLSMDLDPTKHNYKGRSPLEEAALAGNWKTMSVLLPWKSDETSYRTTPLGTCLVESGNLDAITAFIGHCGQQVIEHGQQPMLHVAVNMKSLAVIRLLLGYEGLDINGRDYEGRAVIHCAAKIGDTDMLRLLLAYPGIDVNAPRTTCTSPWKKSALFIAIRLGHEGAVRILLAHESIEFGGAYSWPANEIKYCMVHRRYRIGQIILEDDRVQKNQSVDPLLRAIMQAHEDEAIDLLQDFLISTYIPENNDMVHLHWAIALGRTAVAKRLMDVPAIDVNYSRCKFAPIEVAAATGDSDSLRLLLDHPRIEPRLGKSVYEAVKGGHLQALELLLLQPMIDPIESETLITAVKKDSAEMVKMLLDCPRTDVNQKKYDWSETALFGAVKRGNHDIIWLLLKHKGQTKVDINAVVLYFPEATALDIALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI85</accession>
    <name>A0A9P4UI85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_6122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UI85"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="222" mass="24510" checksum="F9A975F709717573" modified="2023-09-13" version="1">MSRQTVRRRHCTHPGTLNHQTPSTCSITHNLDMRLCGPPERSRFASSGDGASRGAAGALDIVSSKLGALRCPYRNARLCPPLASVQAFSAADRGHSRRRCPRTLRWVGTFTFCCRCTRTSQCLPACPSHFICSDPYPLHLLDVSLGRQHVLAMRCGLPLPSAITMCAGCQAPPVPVDMWKHSGTARNRSPPTWDTDTRLLLHQSVGPFLFFLRLGFILLNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIB7</accession>
    <name>A0A9P4UIB7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_426047</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIB7"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="14">
        <location>
            <begin position="55"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2451536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="424" mass="47137" checksum="ABCD85C369BA5C91" modified="2023-09-13" version="1">MPEDWRVLAAAEQGSRNHELVPTPLIVQLSGLRSGNAVHKSISNLAKIGLIAKLQNAKYDGYRLTYGGLDYLALHTHTKSSTIYSVGNQIGVGKESDIFVCANETGMQQVLKIHRLGRISFRTVKANRDYLRNRSSASWMYMSRLAAMKEFEFMKALRREGFPVPEPLGQNRHTVVMSLVDAFPLRQISTIDDPSALYAELLSLIVRLAEVGLIHGDFNEFNILIEEKPEDDGKAALIPTIIDFPQMVSVSHANAEFYFDRDVDCIKRYFDRRYGFTSDEPGPFFKDSTKNIRKRLDVEVEASGFSKKMAKELAAYMKEHGIDGDAGGVERDEEDEDEDEGLSGEQEEPLGVELETEAPLEQTPAEEVASDSTATPATLASQMTILDIRDNDPLPDLSEIQAMKAKQAPTMSTKAAKTKAGWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJG3</accession>
    <name>A0A9P4UJG3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 17">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P171DRAFT_347308</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the RAD18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 17"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJG3"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="20">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="99"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="341"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="433"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2451673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="470" mass="52678" checksum="A12B513CC245E497" modified="2023-09-13" version="1">MESTFELIDSTDWLATSLPAFEPLEAALRCEVCKEFYNNPVITSCAHTFCSLCIRRCIAIDGKCPTCKSACQADKLQPNIAVREIATKFQEARPKALELARAEGKDDGETATLPSGRKRKREVADGEEEGKRTTRSRQTRRSTRLGNESITDDMPVVIPDSEEEKEDEYIPEGMVPCPICKKPMKEEAVFNHIPVCPAAQEDIGTRKTRSRKDTVFPNPLQARKKDNGPPPTRLSGLHYPMLNEKALRKKLQELGIPTWGTKQQLIKRHQEWLNIYNSNCDASDEARTSKRELLRELDEWERTQGGHATAKESHIMRKDFDGQNYATAHKNQFDDLIANARKRAKDTSKASERTVEATPAGNSGTDPQPPQIDNPEPTPDPPHPYKNNEAALSSIRQKVEDANRTDSVFPPLSHNTKDANMKAAQDAGMHQQDIPLGFAPENPLGSPTRKMPMFRVPEEPVMDVESSTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJH1</accession>
    <name>A0A9P4UJH1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_468522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJH1"/>
    <dbReference type="OrthoDB" id="10422528at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2452180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="188" mass="21739" checksum="D0C6567965F667C1" modified="2023-09-13" version="1">MNTNDASSRTCGNLHVGARFLFKMKPAEALKDTRVETQQTGQMIRRKTWAPNSHMSSHSLGSMVTSGISEDTKKLLEGAIEEFREFKREEEQKRIREEENRKSWRRLKRLWRLSNSGDWTFFGPFGDLRVHHGTAAWIPASLTPAFCTTISALKEEMLLGRRPQQLRKIMISYMLAAFPSILWLQRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJK3</accession>
    <name>A0A9P4UJK3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_346407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJK3"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="3">
        <location>
            <begin position="121"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="410" mass="46830" checksum="BF5BB74DE8CDD708" modified="2023-09-13" version="1">MPPPRAKKLTAQPVRTRHFAGKPAAAEVEEHDSSDQSESEQEQKPKPFVKPKAAPLASSFPKSALKSQLAARKKPEEDLKHLEDDFETESEGEEVGDGSGNGSGSGSESGSEEGSSEEESSSEEEAPKKLLRPVFLKKGQRDKVAVHVKTAEEVAAEEEQRRQEQTKALVQEQIEQRAAAKAAGKKDWDDDVEEADINAVDDTDNLDPEAEYAAWRLREFKRIKRERLAIEEAEAERAEIERRRNLTEAERDAEDREYIEKQKEERGDRGQMQFMQKYFHKGAFFQEDLAELGLDKRNLMGARFEDQTDRQVLPEYMQIRDMTKLGKKGRTRYRDMKSEDTGKWGDFGDARRPRDKGEFGLDERFRSDGYSGRDRDEGATGANARPLGERKRFGEYNNRESKRPRVDDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5R9</accession>
    <name>A0A9P4P5R9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca2+ regulator and membrane fusion protein Fig1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_467685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5R9"/>
    <dbReference type="OrthoDB" id="3550957at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28868" checksum="6EA8C5BAE038C190" modified="2023-09-13" version="1">MRFAVSLPRFIPFVGFHHVLMMLQTFSIILTSIVLAGCSSYSSMTNVYILGLSYTNSTTSNLIPDEKSLPRIMSEFKGDSQLDVRTGYFGMCVHQRGVVWLCSSDASGLAIQVGQDNDPLNLIGAAEKFKGDVIFSGLLFMAIVLAFTSILLLATFPGWHQEIDRETGSEVDIKPFPSRPISYVALACSFVATVLLLISSLWQHIGSVGAAAMAEIAYQGNVHTDIGTQAVSMTWASFMATLIVTLGLHAMIWSLAILDRLTDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6V5</accession>
    <name>A0A9P4P6V5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_422043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6V5"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040308217" description="Concanavalin A-like lectin/glucanase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="23804" checksum="83A89F80843A83C2" modified="2023-09-13" version="1">MKTFALALSATALANAAAIRRQNDYGWQFSNALSTGPVADNSFIREANTTLILPATNTPQTGNLALWPGMGTSGNDLIQGLAISVSDGSAGCEKSSGKWCIVASTLEDSQQMGGFVTASPGSSVTFHYKYNDATAEYDQTVAVDGTVVSTISTDSGKALGFGTAVECQQAACGTVPAHKYVDTTLIMDVADPHYDQTRGVTGATGDMVTADGGKTWTIKTIGIEPHTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7C2</accession>
    <name>A0A9P4P7C2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_369166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7C2"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2439749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31688" checksum="60F781F59FD802B7" modified="2023-09-13" version="1" fragment="single">RIWHNWRRKNTDGLPGTMLMLWASCAVPFGVYAVVQASFLALQLQPQCFGGLTLIAWGQTLYYGNKWRAWTAAAATVGMVVAFAASEAILILTLRIPYYKGVEWPMMMMAILASVMQCLGLVMPYFELAKRQGRVIGIDFWFLLIDYSGAFFSLMALVAQHTFDVLGGSMYIVAMTLETGIFMSQAIWLWRVRHIRDEAKKLGMTYDEYVDAHPTKKLSRKASLETVADVEAAHAEEPAVPEKCLSRTPDTASAQEPTGTNTNTSTAQLNEQALEAPEKAVTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7F9</accession>
    <name>A0A9P4P7F9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_424727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7F9"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000165">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000527">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031558">
        <property type="entry name" value="Vps36-NZF-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16988">
        <property type="entry name" value="Vps36-NZF-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="11">
        <location>
            <begin position="6"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2437846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="596" mass="64273" checksum="660F864ACFA86D4F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7I6</accession>
    <name>A0A9P4P7I6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_399594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7I6"/>
    <dbReference type="OrthoDB" id="2017497at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08589">
        <property type="entry name" value="PI-PLCc_SaPLC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032075">
        <property type="entry name" value="PI-PLC-C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16670">
        <property type="entry name" value="PI-PLC-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42319" checksum="2E8BEDFC9EB6121B" modified="2023-09-13" version="1">MLSKLVPASLALLADGAATQYNTDSSLRMNHIQVIGTHNSYHREISLAEREIFEKYVPSPENFYYSHSSLPNQLSHQAVRSLELDLHSDEKGGLYYPPLIWTISNLTNATTPFDDSVLLKPGIKVFHITDLDPNAVCHTFVDCLTQLKDWSDKHRRHVPILIDLELKTEAPACDAGGVCPGEATNWTLARLLNVDAEILSVLPREQLIVPDDVRVGNLSLEESVLQHGWPLLDDARGRFMFYFDNDPSSDPNSPAKLYTANGHESLQNRIIFTNGVEGEPAAAFIKHNNPLGNNTADIQRQVQKGYIVRTRADEPITTVLSRDTTMRDSAFDSGAQIVTTDFPVYGMAARWGWDYAASLDGRVARCNPIIAPEGCVDAHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8T4</accession>
    <name>A0A9P4P8T4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_435319</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8T4"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2440529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="165" mass="17668" checksum="5035424B5AF93CFA" modified="2023-09-13" version="1">MSSLRIARAALRVRPQAIARPIMRRGYADVASDKIKLSLALPHQSIYKSQDVVQVNLPAETGEMGVLANHVPSIEQLKPGLVEIIEESGGSKQFFLSGGFATVQPDSQLSINAVEGYALEDFSAEAVRNQIAEAQKVAGGNGSEQDIAEAKIELEVLESLQAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8U7</accession>
    <name>A0A9P4P8U7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalase</fullName>
            <ecNumber evidence="6">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_422092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="6"/>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8U7"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000026">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="730" mass="84010" checksum="A1A3F99E1DBDCCD7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8W5</accession>
    <name>A0A9P4P8W5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_457411</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8W5"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="15">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="14">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2440575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="370" mass="39917" checksum="FFAF7AE91317FDD7" modified="2023-09-13" version="1">MDAEHFTSKTSNFPKKKCGVLGATGSVGQRFILLLALHPHFELHAVGASERSAGKKYKDAVKWKQALPFNERIGNLVVKKCVAEEFADCDLVFSGLDSDVAGQVEMDFLKANLAVFSNAKNYRRDPLVPLVVPTVNLPHLDVIPHQRKHHGLEKGFLVCNSNCAVIGIVIPFAALQAKFGPVDQVSVVTMQAVSGAGYPGVSSMDVIDNVVPFISGEEDKLETEAQKILGSVNGEVTGFVDQPMKVSAACNRVPVLDGHTACVSLRFQRRPPPSAEQVKEAMREYVSDVQKLGCPSAPSRAIAVMDEPDRPQPRLDRETDRGYAVSVGRIREDEAGIFDIKFVALSHNTVIGAAGSSILNAEAAVLKGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA57</accession>
    <name>A0A9P4PA57_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_477035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA57"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="292" mass="34093" checksum="1816327B057C2458" modified="2023-09-13" version="1">MTPDELANILDQLLVELDEGMMMRNEARNRPQVNPSYEFPQDRVQAVQRVRNAVKNLDAKDVAIVYDNAQSVEMMDKEFLCRSSRYFEVALNGAFKEATTRIIRLRYDFPWAVYAMLDFLQNGCYYMYPLLCKQYPHITMLDLHVHGYIIADKYEVRALADYAAKNYLRIAADTLVLDWKFDDPDSYDDSLSMPCVYYLPWDFCAAAEVSRFLDSVVLLWRNTASRQDALRTEVLEMIKACFIKLMRLKSFQFLLANLPDFLHDLYESFGEDGVHIKMLARKHKGFRVTFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB29</accession>
    <name>A0A9P4PB29_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_368505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB29"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2440700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="446" mass="47919" checksum="6B7151FC82175353" modified="2023-09-13" version="1">MVALGVAGVSADTCASVASSSSIHIKKRFDIGYATEQANYWSDGGHNPNQGFSSIDGGPLISTRELNEVIYDAGNGVVRVGPGNDWEDVIGALDGTGVTVVGGRIGDVGVGGLVLGGGLSFLSTQYGWVANNVVEYEIVLANASIVTASESHNADLWKALKGGINNYGIVTAYTLKAHPQGQVWGGNIAYTADKSAEILAAVRGFTEYYPDDKAGIIMTAEVTQYGVLDIWLMFLFYDGPTPPAGVFDNFTAIAHLSDDTKSRSYSDLLTHNNFGVIKTEMYTIATETIPLPSVDVGAGFLGAMYDNWRNATESVIDAAGLVGSIAFQPLPKRVARKAKEAGGDLLDLDDDIDRIVLEFDLSWLSKVDSNRMDVATQKLYTGSKDLVEQYQASGKLAEAYLPLFANDAYYRQDYFGRLRTAEFARRVRDGVDPSGFFASRTGGWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBH2</accession>
    <name>A0A9P4PBH2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_434547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBH2"/>
    <dbReference type="OrthoDB" id="3993201at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26386" checksum="2D3176099C7F585B" modified="2023-09-13" version="1">MQAARVSSRAFKAVAAGSKQSRSLHMTGPATYSNLLTSERPAMNHPQSLAGLRYECQVLKLSTTGTKEELRSRLSAHELTNGARTFSSTAVDNSKRPLVGAPVTGHAFRHFNTSRELKSPNDSSTIDFAFVPDFDPDLGAAPVAIRVPILPTTTTPNPSYAFASPVEVDEEYSARVPRIHTVSSHHVHAPAAMSEVHDNNTIDFQGMAFEAVNKLKRPVEEGASMAKQIWGGLVDDVLGPKGKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBX5</accession>
    <name>A0A9P4PBX5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_433737</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBX5"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2442180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="301" mass="32493" checksum="4C97CA40FA9E023E" modified="2023-09-13" version="1">MLSRAARPALRAGLAAAARPAPLNAPAAATYATLREIEGRLKSIRNIEKITKTMKIVASTKLTRAQRAMTESRQYGQTSNTVFEQAETKPLEGDGKKTLIVVCSSDKGLCGGIHSGMSRATRKILLEQPEADLVVIGEKCKAQLSRSNGKNILLSFAGIGKDVPTFADASAIADQISTLPTDYASVKIIYNKFVNATSYEALPIEAFSEEAIQQSPNYAAFEIDDEVLGNLREYALANSLYWALAEGHACEQSARRNAMDNASKNAGEMITKFQILFNRTRQAVITGELVEIITGASASED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCQ4</accession>
    <name>A0A9P4PCQ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_76700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCQ4"/>
    <dbReference type="OrthoDB" id="5426982at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="513" mass="56862" checksum="413902FED8C454F5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCR5</accession>
    <name>A0A9P4PCR5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_476143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCR5"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="514" mass="56609" checksum="38450131AEA17662" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCY2</accession>
    <name>A0A9P4PCY2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_434298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCY2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="110" mass="11571" checksum="CF576C1B0F1B64D4" modified="2023-09-13" version="1">MLPFVCTCVRHCPATSLRPMTALTPAIDLPPTSTGVRVPGPSSPRTKNHPVQSTSHIPRTATTSLFVLSRSPFPLKQTSSSPASALASSTQHSSRTLIPAFVATPTHASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD32</accession>
    <name>A0A9P4PD32_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_434294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD32"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000023">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="501" mass="54497" checksum="D39D31143353AAB5" modified="2023-09-13" version="1">MGSGQKYELPFKLNNPDLLHSLSFVHGEWKESKSGKTFEVVDPGTGKAWTECPTNDASDVDAAVQSSQRCFEEYKKISPRTRAQMLFKWDSLIRENKEDIATILVYETGKPRAEAYGEIDYSTGFTWWFAGEAERIQGSVFTPALPDRRVFTIKQPLGVAAALVPWNFPIAMILRKAGAALAAGCTMIVKPSPETPITILTLAYLADKAGFPKGALNVLTTDLDKTPELSEALCRHDLVKKVSFTGSTRVGKLVAKICSDNLKKVTLELGGNCPVLIFDDANIDQAMGQIFALKYRHAGQACITANRIYVQSGIFDNFLERWNAESQKIVVGHGADKETTMGPVTTPRGIDKALALVNDAKSKGAKIHTGGNKISKNGGYFFEPTVITGVTPDMDIASEEIFAPVCTFLKFDTEEEAVKAANNTSMGLASYCFTKNVDRLWRLFENLEAGMIGLNTGNSSAAESPFGGIKQSGYGKESGKDVAVAEYLITKTGTFTLEGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD78</accession>
    <name>A0A9P4PD78_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_92118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD78"/>
    <dbReference type="OrthoDB" id="5426872at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="197" mass="21483" checksum="353A86B98C20E28B" modified="2023-09-13" version="1">MHAETLAPHRLVSSQSITLENAASILDRYLTNSEVHSHLHPDALITPSGTTFGAQGGSTGGVIMHNLRRVAAGLKGNYMEPEPTPEPEGEEQNALNGANNYKDQSSGGKTDGTAAEDWQDMSEFEREEGAIDVGELGDRSNFVQQEEIEPGHLSGEGKKRKKDDEGKLDKAARKKAKKAKDREFRAQKEKTRAEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDJ5</accession>
    <name>A0A9P4PDJ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_522927</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDJ5"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="367"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2442020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="582" mass="65874" checksum="9075790EA8CCC955" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDS0</accession>
    <name>A0A9P4PDS0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_366862</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDS0"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="389"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="255"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="658"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="894"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="937"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="998"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="78"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="664"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="722"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="937"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1038"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1056"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2441318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1072" mass="116635" checksum="B8C5C4DD0ADDE9E1" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDX9</accession>
    <name>A0A9P4PDX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDX9"/>
    <dbReference type="OrthoDB" id="5398685at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="80" mass="8651" checksum="17A4FCA633BC50FF" modified="2023-09-13" version="1">MSGERNANTDGHVEPDFAQAFKELARGEGAATAMENHLDALEKKIKEMLAKAEEDEKALDSRPKSSANDPSTSEEHKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFL9</accession>
    <name>A0A9P4PFL9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_433376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFL9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040236013" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="83" mass="9196" checksum="28F3BA7698C7EF25" modified="2023-09-13" version="1">MRSTIVTLLSLSLATSSAIAAPVSPPCITNNGMIYCNAQNVPEGYKWPRMERRGQEPTCIMSNGMLYCNTKNVPAGYRWPRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG75</accession>
    <name>A0A9P4PG75_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_33553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG75"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="416" mass="48319" checksum="D879C5C65C55AC90" modified="2023-09-13" version="1">MNWERSVPNQYKEIWKAFFQLSHKEKCQRWVLGPDDADFPRDFHWIGDNINPTLEGNSVAPMSVTWKSRDFPRSSHHHDIISWMKSAFSTLWKRVLESLDDVHGTQRDPKVDERAWDTCAERFAWVLTAGGRLIQDLSKEQQRDLLQSPISIQKEDNYRSAVQHPNPRVSRRILETGKDGDIDNMFISATLFSGYVGKSWRHVKWWHINSMIRALLCSTEQEVDSKDLPSPVLPLVEMTMKDNCLFTCDVDWKPYDALVGDIMGIGAIMTKVGDMILSISPSKKEDMAETEMVQCWTHPILVREAYSHTTEHLHRAYQNLVREHDALEKYMTTPRQTEGMQRVRRVKRPAFPPVYELVGSCFTTAAHWQSPIRGLHLQRFWKLNMVGSEAKRKGPLNYHDYDDRNSDVGLLDIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG99</accession>
    <name>A0A9P4PG99_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG99"/>
    <dbReference type="OrthoDB" id="5385910at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="227" mass="22774" checksum="7DD8AB89D6A42C85" modified="2023-09-13" version="1">MPPIQLHKNAPITAAKADGITPQTAQDTPQNLPPTRTTPASIPATTTADASLPPPPQPGARPLAPTAPSNTYTPSDAPPAPQPAYTATHLTTETRLAGPPPQYSIPPPSTAQLAGRSTIPSTTASGPGPTSLDTSGGVPKASPFQQPHAGGAVSDLRNSLEHPPGYQQAPDNSPYAAGGGSLGTGGVSGAGANEGEGVGAQAWNMLSRAGEALKKGEEAVWKAVREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGG7</accession>
    <name>A0A9P4PGG7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_48216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGG7"/>
    <dbReference type="OrthoDB" id="10646574at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="161" mass="18024" checksum="A7FACB7110CF5819" modified="2023-09-13" version="1">MRHWKAILPLFEAFATTSRRRDPRTRYRVRRGGPEAPPELATPPVVIIAGRAADGNVWRANVGVAPETPKRPPLLRSSAAGPTRSWMQVSRQRASLFALLFHKARPITRPWRDSEHHAARGNHPTSPSQNVHLHHHAQLRSRLAAGPPSILLEPMIIAAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHH2</accession>
    <name>A0A9P4PHH2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_414113</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="795"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="516"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="614"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="674"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="948"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1106"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2444241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1468" mass="163739" checksum="EEF6A4425F21C31F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHQ1</accession>
    <name>A0A9P4PHQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 ClCP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_389517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHQ1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="513" mass="57148" checksum="980179AFC55F723C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI62</accession>
    <name>A0A9P4PI62_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI62"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="410" mass="46349" checksum="4524230FAE7A9640" modified="2023-09-13" version="1">MEAGPQDKSPAMAALETAKNELKKNHPDQSTVIEAFYSDLTILPDHDIVLMKGSSSSTSALVGLTTLGTYEVKTKNLLLVHVKGKTKEVLATDSGDLTVSSDKGTVNFYHRSITKRDEHRLIYKMSHADVFTLREHYTCHPAFGALLEQLETAGSDVIPKALHFVCRALMAHSEDEEPHPKLAQDIHRLYGHVKHHYIEDAQDAKKQAKTGKGKSDKKTEQQGVINAYAWIPHSGKIAKHRSTSKATMSVEVDAVDGQVKSIYLARVLVPRPIAEDAVYEGMNRHDTLCVQVYTDCAYEPRYEELLPMEGQTYRDWQEYLITTGDPIFWGEYEQYTFVAPAIANSGIAIKGNETGEWSLFRNIHELRQQKVKSLERDLFLSEAFTITNLEQACKVWELGDLMLFRYRKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIC5</accession>
    <name>A0A9P4PIC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_431511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIC5"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040134996" evidence="1">
        <location>
            <begin position="22"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="418"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="785" mass="83302" checksum="E787C4AEBAF4AA15" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIP2</accession>
    <name>A0A9P4PIP2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_431673</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIP2"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2444886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="262" mass="28370" checksum="BE37D44DB20867B6" modified="2023-09-13" version="1">MQQPPATHDPKAPTIEMSLREHLLAAGAGQSSAPQPMQQHPHPSPQQHAIDPAIAGQQYQMTQGETAHMGDQGQGNAKGRRELSTSKRAAQNRAAQRAFRQRKEEYIKQLKDQVKEFEQLCELYKTLQTENYQLRDYIINLQSRLLETQGEVPPAPAGVDLSRHGEAPNPNMNQAPPQPQPDQQAQSQQNANNNSNNGGLSDRQIGELQMAAQAAAAAQHGGPSLSNGKHPNDGSPFSGDYADKRQKTGDSPASGATDPNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ26</accession>
    <name>A0A9P4PJ26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_432946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ26"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="68" mass="7252" checksum="CD33A2FC4FE764F9" modified="2023-09-13" version="1">MLDLLGPSPPATICHGRRRRRAKSGEKRSGAEHEAVTSSLVGRQLSAALQPAREVRWPGPGHVDMVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJV3</accession>
    <name>A0A9P4PJV3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphodiester glycosidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_430772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJV3"/>
    <dbReference type="OrthoDB" id="5188439at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040204481" description="Phosphodiester glycosidase domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="56801" checksum="4722EB11476338EC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJW6</accession>
    <name>A0A9P4PJW6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_430936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJW6"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000061">
        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000011">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="442"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="830" mass="95904" checksum="9FB3FD89723CB374" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKE0</accession>
    <name>A0A9P4PKE0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_431600</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKE0"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="17">
        <location>
            <begin position="251"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2444798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="330" mass="37523" checksum="FA0DCCF552F14168" modified="2023-09-13" version="1" fragment="single">MSRRQVNGYRNESPEPPVYDDAHRAFLQAFFSHSVFTIDKLRPVVAAILSAQDPERPRLEGDITEPMIMSLVQNTNAKISHFDFEIHSARDQTKGDRTFALVNTTSDTFTQLATAFTPDEIAYIKRLLDAMFEENNSRTREIMAVKQMRANQLAKAPARNRQSQAATQLDADADEPTQVESNIKSINHGECQRVLQMLVSQGFFQLSSHHYYSLAPRGLLELRNYLKETYNELPAEDDDEESEPIVRIRDCEGCQEIVTIGLRCDNRDCGVRWHTRCANQFFGRQGSARRCPKCKTAWTGTTYVGEKADRVQPRSSTAGRSSRAQHNEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKF0</accession>
    <name>A0A9P4PKF0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_520913</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKF0"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2444813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="173" mass="19075" checksum="C9DFA4F81618124C" modified="2023-09-13" version="1">MMGIANMQPRQLAAQVLNFALVLSTAFMLWKGISVVSDSPSPIVVVLSGSMEPAFQRGDLLFLWNRGMDTQLGEVVVYNVKGKDIPIVHRVVRRFGGGKSPLRLLTKGDNNLADDTELYAAGQSHLNRREDVIGSVVGFIPFVGYVTILLSEYPWLKQAMLGIMGLMVVLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLC7</accession>
    <name>A0A9P4PLC7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_472182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLC7"/>
    <dbReference type="OrthoDB" id="2558704at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01094">
        <property type="entry name" value="Alkanesulfonate_monoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="45"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="396" mass="43447" checksum="F34A1CCF1B1A9124" modified="2023-09-13" version="1">MAKTSVRPGGPPLKSPLDYPDSPLSRAISTQPLLLGVFLNLQDIHVSSQPTSNSWTYDYNLACVQEADRQGFELAFSRMQWLPKGGYDGEASLDAFIALGAMASATKNIHLISTLHVLYGPLHPLHLAKWGATLDHISKGRWGINVVTGHRAIEHEMFGGGRIEHDQRYARSGELFDVLNSLWAEDENLSYDANESGKGNAWRLKDAFITPKPLYGRPVLVNATGSPAGIDFASSYSDIVFITSPGGAHIDSALETLPAHIATIKEAAKQKGREIKTLINPIVVSRDTPEEAEAYAQAIWEGKPKQEGAKSFGENKHYESDAQAWKGRKDARHKQGLNIGGNIEIIGSPEQVADQIEALHKIGIDGVQLSFYDFLPDLEHFGKKILPILKERGLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMD8</accession>
    <name>A0A9P4PMD8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF887-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_382923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMD8"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="67"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2447789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="318" mass="35583" checksum="BD8A701C3CE519FA" modified="2023-09-13" version="1">MRDPIPAPALSIELTKPLSNELSLTTLPYHAHEILLGFLFYHFILCYLSPTLSRIVCPQRYNGFDKRTRLNWDIHWVSMIQALFVNAAALYVIFSDPQRKEMDWKGRLWGYTPASGMVQGFAAGYFLWDLQISSQYLSISGVGALVHAIGALAVTCIGFRPFGNYYGLSFVLYELSTPFLNIHWFCDKLDLTGSKIQFYNGIALLATFFGCRIVWGTYQSVLIYSDIYTAMTTSPSDPLVSMLDEGKCETNASSTSPGYMSGCEAGGLPMWLVSIYLVGNTALSLLNFYWFSQMVKAVRKRFVAQPGSKTNGDTKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNB5</accession>
    <name>A0A9P4PNB5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_409978</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNB5"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF124">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="50"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2447361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="422" mass="46449" checksum="CDC65E9C307A709D" modified="2023-09-13" version="1">MTTINDTTAILPPPDGYVVDFDNPTIQYVTESYAVVAVEMTLCFLFLVQRLYTKIAIMKSFQLEDGVVILAWVFCMGTQVCGLLGLVHGAIGRHAWEISVEKYVFYSKVILASPLLYAIGTCAAKMSLALFYRRLNPNKVFQGFVWFTLFVCPAAYISIFFSLLFACKPIAASWDPLLLALPTTVCLNRGGIYLSQALIGIITDVLLLMLPIPTVLKLQMPNKQKLGLVAIFAVGSITIVTSIVRLIILIPSLTTPDQTWVIGEGFLWIFVEANLLIMCCCLSTLRRFFKHFAPRLIGESSSGNTSKTHSRGFSRNNAHRTFGSAGAKRTLDTLMHTNNDDGIPLSSIDEMYKHGANVTTNARPMCRDSDSEEAILFERSVQVTYENRDDSTVAGGGAAGGYEGRQGNQPRIWTGKRAPGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNI5</accession>
    <name>A0A9P4PNI5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_429110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNI5"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001067">
        <property type="entry name" value="DNA mismatch repair protein MSH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2447466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="703" mass="77522" checksum="590029056A45A155" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNR4</accession>
    <name>A0A9P4PNR4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent mannitol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.138</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_381181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.138" evidence="4"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNR4"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00069279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="266" mass="28605" checksum="4D64D2EC313BA610" modified="2023-09-13" version="1">MPSAIPEATELKDLLSLKGKVVVVTGASGPTGIGIEAARGCAEFGADLAITYNSRSSGAEKNAEELAQKYGVKVKAYKCQVGDYANVEKLVQDVIKDFGKIDVFIANAGKTADNGILDASVEQWNEVIQTDLTGSYNCARAVGLHFRERKTGSLILTASMSGHIANYPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSISPGYIDTGLSDFVPQDIQKLWHSMIPMGRDAKAKELKGAFLYFASDASSYTTGADLLIDGGYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNU5</accession>
    <name>A0A9P4PNU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_411043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNU5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="276" mass="30376" checksum="6EE9D9F560559DBA" modified="2023-09-13" version="1">MARFVPKQCLPPDLAFFTQISGDTTEQVARHLLDFIPPIPPGSIIHDNACGSGAMTVALMEAHTKNIVIHATDKVPSLIDTMSKKATSLSWPVLAEVMLSEALSFPPAKFTHSFTNFAIMLIKEDAAVAEGIHRTLRDGGVAVLSIWDAPLPVQVVKAAHEFLRSGQSALPPAIARGSFNAEDLRSLLEGVGFTSRGLSFGRTKAVLEVADLRFWATAVWSFLGCPQNGWIAQDEQRWDEVIDFIVDWVQNWENYRKLDSGAVRLDMEAHVVVAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPI4</accession>
    <name>A0A9P4PPI4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_430748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPI4"/>
    <dbReference type="OrthoDB" id="3783332at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Leucine-rich repeat" evidence="2">
        <location>
            <begin position="320"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="529" mass="59522" checksum="7AC5E61545A827F7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPM7</accession>
    <name>A0A9P4PPM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Stress activated MAP kinase interacting protein Sin1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_353470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPM7"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000263">
        <property type="entry name" value="Stress activated MAP kinase interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="339"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="721"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="833" mass="90979" checksum="5A5BD05956F30B45" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ01</accession>
    <name>A0A9P4PQ01_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_187726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ01"/>
    <dbReference type="OrthoDB" id="3775757at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="310" mass="34675" checksum="D0C74B71CAFA034E" modified="2023-09-13" version="1">MKTPAAKSHAHKMTMPPTPPSEKPNPSSPAPPALSNPVPSSPTPELHTPRERRSISNRFWDKNASRAKNGAAGVDLASDSSDPDDDSEAARTKKHNHLHSKIKRLLALETGAVRIKTLESNETVRAYTKLLEAFAHKPKTKRKRAKYTEALRVFLEEHDQILDLYNQYAVLDGDVRKDRILPEFMLDEASAASLKKDDKERGSDVRRAPAKHALNGGDDSDEEGVVTQTVKSGEDFDEPSVFNTRGLTVPSIFNRKTSATAEKNQRRFLLHRREGPWTRNGEGSEHLDERAVRNEDETPTRPLSKKRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQS1</accession>
    <name>A0A9P4PQS1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_227295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQS1"/>
    <dbReference type="OrthoDB" id="2307332at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF5">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2447558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="430" mass="48914" checksum="6FA66BCD4DA04A14" modified="2023-09-13" version="1">MSSDHRQNEPRKFCRSPPTPRSSTEIEDTTRRTRSGRTVVPSSSPMEEEKPRPKPTPKSKKAKTGKSEKPKTPKLTAPLSILTKGMVNIPVRNMEEWVNRSAETRKKEVEKRNGYVTRPMNSFMLYRSAYAERTKQWCLQNNHQVVSSVSGESWPMEPPEVRELFNEYAKIERINHQNAHPTYKFSPSKAAAPARKRKREFSDDDPSDVEDAEWNPSSDRSRSRSSKRMSQGPGFPMNGMSPEFFDQRFGPNVVGMNRPGWEMTNEWRPMPMPMEDPYGQYYQTSVHPGMGMHQGLMEDMRMRRADTPISTMQLSQDTALLGLPGGNASELLQQMHSHSDTSLSGEPQVDPLLMSFDGGHHELGVPASHPEFRNGHMAMMDGELDGHSVDSFIGAEAAHEEYRTEAWHPYANMGPMESPESEFDKWLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQZ9</accession>
    <name>A0A9P4PQZ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_231514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQZ9"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000614">
        <property type="entry name" value="Zinc finger protein 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="484"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="644" mass="70558" checksum="BA608A5019A4874D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR25</accession>
    <name>A0A9P4PR25_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_428633</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR25"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="14"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="586" mass="63551" checksum="3699C820F564ACC2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRU8</accession>
    <name>A0A9P4PRU8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_480362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRU8"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="28714" checksum="75E812811B47A1D0" modified="2023-09-13" version="1">MGYHKKKPSDRKNSWVMLAEGSGYTPLPGETTLYQSPPRTTLSLQSPSQNTPAGTYSQQCKSGVIYLTNRRIIYLPVSPTPTFTSFAVPILNVTDSRVTAPWFGANKWEAAITPVYGGGIPASHSALELVMEFKEGGAFDFATTFERLRERLRQAVDVAAAAGDGVESDGRGAGALGGVNLSSVHLEDLPAYEDTRGHAKVPEGMPSPPVGRGSVGTQGTGSTANRSSPPLGSPRQEGFQAPPSEPPPGYEEVQRGSVADELERRLRGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS41</accession>
    <name>A0A9P4PS41_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_428414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS41"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021601">
        <property type="entry name" value="Phosphatidylino_kinase_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11522">
        <property type="entry name" value="Pik1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="693"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="987" mass="108967" checksum="101D727CF4C2765D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSL5</accession>
    <name>A0A9P4PSL5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_451708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSL5"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040155845" description="Sushi domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35362" checksum="CF0968E7F32C1E7C" modified="2023-09-13" version="1">MGLPLLLRVLPLIALRSSASGDTTAAIGTFADVNTECKTCPHSLCPNILAYEQGESANVTCWTRGTRIIDTTLWLRSTSDCYVTEYDLNDNITDYTSALPYCGPDSEDEVLTLEDATLKYKTECRICPSISCDTVTFLKEETDVELTCWTPDGQVIIDDPYWMRTTNNCYVAQKNLYSKPDITNLDPCGPIPYLEIEKHFNENGTSDIDKRDAAPEPEVFAPSYLINATVGEDYALCRSCAKETCRVKRRYMFDQEVWLQCLVNTNGTWWSETTDFCYVKNSDFWQSPEGDYYRNPLCEYFEEPGTGPGDGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT19</accession>
    <name>A0A9P4PT19_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_480939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT19"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="173" mass="18930" checksum="17B70D8E88236C30" modified="2023-09-13" version="1">MAFPWHLGPREHSHCFRQLFDPLAALDRKPSVCARLQSHLVWHKGDRVTNRILVLLPLYSGRRNCVCPDVPQAFVSGHAYCGISTTQQPPLPHALLQHDTSLEQLQDLTQGSATIMPLPATTATQSSGTSAPHNDGRSLQTATCVSASPIHMHPICAVYAVAPYSHFAQASRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT21</accession>
    <name>A0A9P4PT21_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type III-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_348679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT21"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="184" mass="19709" checksum="73093C520B2E80BB" modified="2023-09-13" version="1" fragment="single">FGTGLHYTNFSSSIRSNTASSYAIADLMTTCKNSNAKYLDLCSFGSPVQVEVTNTGKTTSDYVTLAYVTGTFGPAPHPKKALVSYQRLFAISGGSSDTAILNLTLGSLARVDEKGNKVLYPGEYTLLIDNKPLAMVNFTLTGDQVMLENWPQPPANRTGKGLSGFEGYFVGGYGSDQKPISMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT30</accession>
    <name>A0A9P4PT30_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_440334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT30"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="192" mass="20295" checksum="2C64D8B4ADD3124C" modified="2023-09-13" version="1">MTQRGDGSRHSWHASNSFAGPLPVVVPGGLQRGIATTTAPPIEKRASSRSTERRLSGGIRPGRCILSMRLQGAEEGLRACGDARKPRHRSSIFSLGCRGSQSTSHVKLEIGTSGVTAEVVRAWYIVGAMSVQTPTYYCETAADEGEIAALFASGRSAVASHAAPARFTTLVGWCESATPRKPSSDLAIDLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT91</accession>
    <name>A0A9P4PT91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_336276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT91"/>
    <dbReference type="OrthoDB" id="3789852at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="167" mass="18764" checksum="3A22F162F9ECB941" modified="2023-09-13" version="1" fragment="single">RKYIKLDNSYYSKDTPEVQIAKVLEQQKNMNGGDDLKKWSLSARKALKGGRSAAILVPKRGLSVFEAPKLAMVVSSPVIRNYFVEHPESTEFPALNPHFKAKAIESIAHWLRIAITVPELQNIRIPKLGPKMSDDDLKNGLNVRVAMLILGMGKYVDDFPAKYQDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTW9</accession>
    <name>A0A9P4PTW9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_138801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTW9"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="102"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2450361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="589" mass="65072" checksum="98F5D03051EF3BD6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUP2</accession>
    <name>A0A9P4PUP2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_378081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUP2"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="492" mass="54318" checksum="4A2C824B45F02493" modified="2023-09-13" version="1">MAKDYKQLKTQHVSGHVGSSLSDINSVSLSMPLTILLWSVLQSRMRQFTPYTASAFFIDLLLSCGITLVATTVYSSSLWLLNTLLVAPVAMIYLTNSRPTMPRQRSARPPKNSDDAEQAKLDSLPIKPFLTNYRGSMMVITCIAILAVDFRIFPRRFAKVENWGTSLMDMGVGSFVFTNGVVSVRSSLKTETGKLPSLPKRVFASLRHALPLIVLGTVRLISVKGLDYAEHVTEYGVHWNFFFTLGFIPPFVAIFQSLFALVPSYAVLSCALAGIYEIALDNTNLSAFILTAQRTDLLSKNREGIFSFFGYLAIFLAGQSLGTYALPRQVPLNKDAAITTWLRQSILGKLVLSSVLWTALFHLSISYYGLGLGVSRRLANLPYFLWVCSFNTYHIAICCAIETLIFPNLHKAATRGEEKQRCREATSQILHAVNRNGLAVFLLANLLTGLVNLTMPTLDMGVVSTMAVLVAYITCIAGLAVWLDRADVSIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUT0</accession>
    <name>A0A9P4PUT0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_427124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUT0"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040207430" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2450826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="567" mass="63408" checksum="A4FDEB3CD79A0B0F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUU4</accession>
    <name>A0A9P4PUU4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_440195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUU4"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="119"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="332" mass="37562" checksum="2461FD8AAF54F96A" modified="2023-09-13" version="1">MLDLLAWQHPLNMCALNKQPRFRPYPHGPNYQTQSKKYDASFAKSSPAKRYGSQGVRLAKKRALFDGDAQKVTTTDRMPFLRHLFSYHDNEDVEPCCRSQKFQLFKSPASGCQPCNNVAADARPIVVVAHSIPEDLHSLTKVGFEITQAAPVAAFMDTQKIARELFWKESRSKNSSLKDLCALVGFRPVNLHDCGNDAAYTLVVLLSLASRILGDHTRGNVEELIQAALMSAKTARRKIKEMEQEERVVGDWADNLDVMGWEVCASAWGWSRLRPYAPCMRKKRLNMLGTYRKFVRCAENDDVAGGLLQTWASVRIWRYRRTGYGIRGSNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV76</accession>
    <name>A0A9P4PV76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_517532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV76"/>
    <dbReference type="OrthoDB" id="2012566at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="450" mass="49985" checksum="D1972C411FF522AF" modified="2023-09-13" version="1">MLPPRGSSSMGFSNSNSSSNSWVYYITAGLASLPEETLHHIITCKEWEALEHGEIGEKEAVQRIAASLTLPPEHEYKLMTLFYQSAVFNLGISPQATELGSHVLRGKAWLRANARHLLNQIESSEIFEDTFSQFLIMEATNDTSLLHLHPYEDAETNSDIRNTTNLAKQWNYFLGKPVGTTMTFPADVDSTSYALLAFTPTLAVNDILDSMLANRNHDGLVQTYWDQTRPRVDICVLTNVTRTFYKYNRSADIQESLAYVGKALNAGTYMSGTRHYCTAEVFFFFLSQLIADHPYAPEVQLLRVPLAKALAGRMGVYENEVTQAELDLAEASRAKGEKYEAYVPEVDSLAIAYRVLACQSLGLRPQGIEDDIKRLASLQCDDGGWPLGWVCRYGRSKLRIGSRGVVTAYAIKALGTEAKMSAQIVDVVQPDIYQYLNEHHGMPIAGSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVF0</accession>
    <name>A0A9P4PVF0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_427706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVF0"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2449501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="278" mass="30316" checksum="A8F3E19269EA27AF" modified="2023-09-13" version="1">MAEGYKYEYFNVTFPAEYVAHVEINRPEKLNAFVEQMWLNLSAIVNRLSHDPNIRSIILTGSGDRAFTAGLDVTAASQGTLSQNNSDAARTATSLRRHIFEFQDCITALEKCEVPIIAVLHGISYGLALDLCLACDIRMCAADTRFSVKEVDIGLAADIGTLSRLPKAVGNFSWVKDVCLSARIFGSSEAEKVGLVSGVYGGKVEVVAEGLKLAKLIASKSPVAVQGTKEILNYSRDRSVEEGLRYTAVWNQAMLQTTDVKDAMLSGLQKKTPKFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVS7</accession>
    <name>A0A9P4PVS7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVS7"/>
    <dbReference type="OrthoDB" id="3782435at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="184" mass="20222" checksum="51EB1569C0F10170" modified="2023-09-13" version="1">MDPASAHPMPQSDLISSWLLSTQNSCFLPSPPPDEAALEPFPAPPKRKRAMSLPTTTPVPSSHRSDTQKRRRIEYSDNVLPEQSASQLGSNTPLTLNEKNTFSSRSRLFSKRSSSPARETPIILRNVWPPVIAESLNGVRDAPLKHVERLSDRLPEGVDCGFIPKGLEVCDSNIVAGPRMLLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWF2</accession>
    <name>A0A9P4PWF2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">P171DRAFT_204253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWF2"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="136"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="302" mass="33681" checksum="19B94181351115E4" modified="2023-09-13" version="1">MLPGSRRKSAPRLRLLVQGLFHRGSRPLHIVTFSVYNTAIAIHALATSTMADSTKPEHLNTSALGTRAYWDSAYTTERTNFALDPADEGTVWFSDAGAEERMLAFLESLADVDVLHKEADGEVAQGEEESDFALPTRFLDLGTGNGHLLFALREDGWEGEMVGVDYSAESVRLAEEIKASKGAEYEDVRFREFDILKGEAEKEWLGEGFDVVLDKGTFDAISLSDEKDAQGRRVAEGYREAVEKLVKRGGRFLITSCNWTEEEVKGWFEGSELEYEDRAEYPSFTFGGKTGSSVCTLCFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWT2</accession>
    <name>A0A9P4PWT2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_426151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWT2"/>
    <dbReference type="OrthoDB" id="3889716at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="776" mass="90222" checksum="2DBC47B1BBD30D63" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWT8</accession>
    <name>A0A9P4PWT8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_138770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWT8"/>
    <dbReference type="OrthoDB" id="3801246at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="529" mass="59443" checksum="795E5B9A76F5F1B9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXH8</accession>
    <name>A0A9P4PXH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase/serine esteras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_426464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXH8"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000223">
        <property type="entry name" value="Lipase/serine esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="4"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2452070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="445" mass="50299" checksum="FDAC79FBCC68081D" modified="2023-09-13" version="1">MAGKADHLCVLVHGLWGNPQHLDFLRNSLREKYTDDKIHVLVTKRNAGSFTYDGIDTGGERVAHEIEERLDELAQTGHAIQKISVIGYSLGGLIARYAIGLLYSKGLFERITPVNFTTFATPHLGVRTPRRGYFSNAFNVLGARTLSTSGRQMFLIDSFRDTGRPLLSVLADTDSIFIRALAQFKHRSLYANVINDKTVAYFTACISQTDPFERLDEVTVNYLHGYEDVVVDPQHPVDPKEPEALPVFRQRLSNGTRAFFGKIPTIAFFIIFVPIGTTLLLSNAAIQSVRSRQRLRLHETGMAGIDVKGYRIPLMITSARQEMEDMYENMNNRQGQDYLDAAEEELASPTQQRSYSFSKQAAPADFEANLAVAEKSETQLEFPTLALTEHQFKMIEHLDNVGFKKYPIHIKKVGHTHAAIIRRMEKPSFDEGHIVARHWLDNFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXR4</accession>
    <name>A0A9P4PXR4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_427122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXR4"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="94" mass="10958" checksum="445891B192547D8F" modified="2023-09-13" version="1">MIYQILFCSQEPIHISGHNPKSSKVGEDESHELGLVVPCLRTCRQVYWEAVSILYGNNTWLITRPRDLHDQIYHQIQYAPTWMRGIGSNFDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PY12</accession>
    <name>A0A9P4PY12_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_425797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PY12"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2451278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="195" mass="22269" checksum="8F5BD36070ABB536" modified="2023-09-13" version="1">MTEHDDLHAEPTEGFKVGEKKTIDEYQQLDQNDESLRKWKESLGLGGGKTLSDPNDPRKCIILSLGLEVEGRPDIIIDLKTPGALEKLKDQPFRIKEGAQFRMKAQFKVQHEILAGLKYLQKVSKGPLSNKMQEMMGSYGPNTEEKPLYEKKFESETAPSGLLGRGHYKAVSKFVDDDNQTHLQFEWSFDIKKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYQ2</accession>
    <name>A0A9P4PYQ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyltransferase family 62 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_347329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYQ2"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="513" mass="58839" checksum="4D6C8391A91F4CD7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZ34</accession>
    <name>A0A9P4PZ34_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_426024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZ34"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="103"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="442" mass="50512" checksum="A0C87D1733D58612" modified="2023-09-13" version="1">MPNRVLLRSPRRKRAFPKFVLRFLKRGLVLECVLVVSAVLSRVKAVSAASLLLSSFCPTMDSFAAIFENPPDPSDPVPIYNKPSIIYGATLPFHILAWFAVALRVYTRLRIVRAPGWDDSLIIISVLFNLVSLITFYGGFHHGLGKHLYYIDPNELVTLSKFLYVQNAAYYTCAGFIKLSLLCQYLRLFQKGIVRQICIVLLVLTGLWTFFWLFQGWFPCFPVSGSWDRGQIPPAKCWGLRSDNIQNSLATFVAFAATNMVLDTTIFFMPMTLYFKPTTTGPRQVLALLMLFMLGSVVLLMSVLRLWATIRHNRNDVNSLDFTWWYPLTMILASLEIDFAIICASIPIFWPLIVNALPQIFVTKEVRVTHHQRLPDNTNTDYEMERTYSVKSSGGDSQENLRDLHEHPKTDYSDPFVVDHVTGQLENNAQVVSEKLQKRRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5T5</accession>
    <name>A0A9P4U5T5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_448207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5T5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="182" mass="20138" checksum="4E66C34127958B6D" modified="2023-09-13" version="1">MSRRYDLIHQDPPLQTSTSRMTAIAFLRPHVRSKLCLTMHHVVPLPRGSAINTRGSTTAIQASPRTPHVKSGAGIAGTVQSRRLRPGREKHAMSSPRRGLHKECPWTHRMLQSGARIKRATFPRQPRTRARQAAVGLKLDMLDLSVTDASRLRAAIGALDMQVPFACSRTGHPELHGQTIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6G4</accession>
    <name>A0A9P4U6G4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc-binding loop region of homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_525869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6G4"/>
    <dbReference type="OrthoDB" id="5386048at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.75.10">
        <property type="entry name" value="Homing Intron 3 (I-ppo) Encoded Endonuclease, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008704">
        <property type="entry name" value="Endonuclease_Zinc-binding_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044930">
        <property type="entry name" value="Homing_endonuclease_His-Me"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05551">
        <property type="entry name" value="zf-His_Me_endon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-binding loop region of homing endonuclease" evidence="2">
        <location>
            <begin position="427"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="508" mass="55946" checksum="669EBAA77841E72B" modified="2023-09-13" version="1">MEDEQARQAPPRKRFFDYLLSSTNNERPTKQRKDELARNKDGKTSGENPVYGNDDHGLITPHNSDLLSGLDDEILGKGTPDDPVRFLSWETGNVISRKHHGSFIELSDDEDEGSKATSQDALKSFGENTVESIRGRTSFVRRQSSPGNKRLASSNDSRSFVLSPSDLGGCPTLLPPPPPSPAHTAAFTKPISTAPSLQGEVLLRNESEHSEDPGGLVKLEEYDLEISDDDDFFEDALLGCDTLTKGGSWNPSCGGVSKEAQTKTWWKQPTSTTVAVAAEEDLFSVPTTQGRNDLLHMPTIASVADEHSESISSTNTHLVASPAPVKLSESIKPNKSLDLSSRKRLFFDNYYHLRRARLDKVLQKYYSGIQGERSPDGCWLYTGGRLPKPPNQGLSMTVTFRHDGHKESLCLNVLVVKKLLEGSLSQEHIDGIVENSWHASHLCGNWTCFNTQHVVLEPGSVNSNRNACFRAIDGPCNHDPKCQKHLKLDKSRLRPVADPVSLGANESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U778</accession>
    <name>A0A9P4U778_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_525978</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="616"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1349"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1595"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1351"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1366"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1395"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1421"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1438"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1468"/>
            <end position="1478"/>
        </location>
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            <end position="1493"/>
        </location>
    </feature>
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            <end position="1616"/>
        </location>
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            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1645"/>
            <end position="1654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2438893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1663" mass="184394" checksum="F74D5FB1A677C7CA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8H8</accession>
    <name>A0A9P4U8H8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_65418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8H8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="140" mass="15137" checksum="A8DCE13AE428F2BF" modified="2023-09-13" version="1">MMLTSDVANKKGHSIVCDQRDYVVTGGIVGTARLESKYMHPCRGKQSNSWAHLKPLSCRASATCVQFTHLSQARSTAQPRSTPSAISARTRDFAWQKEDQVVGCELPSISVSGVPWSYTVAQANRARKLVSSNTDGAVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8V0</accession>
    <name>A0A9P4U8V0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_489136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3763456at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="214" mass="23938" checksum="1DF30F01BCA7B29B" modified="2023-09-13" version="1">MDIPSAGAHFARDPCLYPMDPMEMSCFDIRAAHVPTVPAPRRSQDAKAKERRSTSSAPRISLAGYTNGKGYWIASSSLINKSSRLQPTQESQLEQQMHQSTCLNLNANVNSAESDLWILPDFDDWEVDNETPQQEHFQAEKKQGAWAPLVKRAANSNRERLRRRLEGDGWDFVGGRYGEDDAVLKEEAEASEGSQESVDEEFDVVVLPVVRVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U939</accession>
    <name>A0A9P4U939_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_465310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U939"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040538091" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="19"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="536" mass="59011" checksum="1F05F12A7A87829D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9Z7</accession>
    <name>A0A9P4U9Z7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc knuckle-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_366312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9Z7"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8433" checksum="F4675516CD5B7678" modified="2023-09-13" version="1" fragment="single">MFSRRGGHGGRSKATPNTTCQKCLQKGHYSYECTVSAQERPYKPRPSRTQQLLNPSLKPKLTEDVPSDLLRSKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA35</accession>
    <name>A0A9P4UA35_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_464546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA35"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="57"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2442775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="522" mass="57567" checksum="8AB056F0C082A3C1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB14</accession>
    <name>A0A9P4UB14_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_522385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB14"/>
    <dbReference type="OrthoDB" id="4850726at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="690" mass="78609" checksum="89E49977E1C4431F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBF2</accession>
    <name>A0A9P4UBF2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_445570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBF2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="688" mass="72967" checksum="005B23307E6186F0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC37</accession>
    <name>A0A9P4UC37_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_323611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC37"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="237" mass="25988" checksum="BDB9D586B436B4D4" modified="2023-09-13" version="1" fragment="single">KLRILCLHGFTSNGAVHAHQLRRLTSQLPDYDFLFPSGPHQVNIADQMDMTTPANQAWSSIVTSASASGHRAWWFARDGDTKSKTGGGFVGIEESLAYLAAYIQERGPVHAIWGFSQGACLAGLLCALLQSKHAAHPLRRYLEAPVDLGIPTPLAGVVFSGFRARYARYDDLYEPGIDVPVLHVLGEQDALVRSERSEALLRVCKSSERIVHPGGHGIPKGEADMAKIVEFTRKYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCC7</accession>
    <name>A0A9P4UCC7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_430709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCC7"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="480" mass="51073" checksum="1BDFAF57567416F9" modified="2023-09-13" version="1">MGDISLTQVLETLGKAFPHTVLRPGSPRYEEENGKFWNRDNADVRPAGIVAPESAAETGAILKVLSDTKTHFAIRSGGYMPVPKYNTSPAVLISLSRLSSIELLPPTSPSPPLVKFGAGNTWGPIYDVLSPHGLVVPGGRSRDVGVGGFLLHGGVSHFYASLGWACESVVEFDVALASGDVVAANASLNADLFWALKGGSANFGVVTAFTMRTAKLEKMWGGVRVAVGTGETASRVFTALHAGIQGDVDEKAHVEVISFYNPTACAGGDALFVLSLAYAGEVEKEGPAALKGFMEVEAVNDGTRVTTQRELAADDKVNVGYDKRGLFRAFSYRGGPQVTLDIYTEYYALVKASGVFDADPSAMAALLWLPVGQKLASGTGVMTLGEDAEPYLSCNICIRWSSPSVSERIHAIADGIADTLKKKLQDAGVFVPFTYGNIAGVQDMTFAGLPETTRRRLREVAGRYDPEGVFQKQVPGFKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCH3</accession>
    <name>A0A9P4UCH3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_408832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCH3"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040516698" evidence="1">
        <location>
            <begin position="19"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="515" mass="56397" checksum="BB4FF304A177D9ED" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCJ4</accession>
    <name>A0A9P4UCJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aflatoxin B1-aldehyde reductase GliO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_429726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCJ4"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="328" mass="36465" checksum="0C5F8ABFBF2179A7" modified="2023-09-13" version="1">MATSTPNRLILGLMTIGPDTHLGARITSLDTYKQCLDYLSQKGYHELDTAGSYVGGKQESFTRDAAFQQRGFEIASKVYPVQPGDHSPAKLRSKWLASLEKLGVDSTDILYLHAPDRATPFETTLECVNDLHQEGRFKKLGLSNYAAWEVAEIVGICVRRGFVRPSIYQGMYNAITRALEPELLPCLRKFDIDLVVYNPLVGGLFSGKYSTLEAPAEGRFSDTAGSGKMYRERYFKESVIEALALVEPVAKEHGVALIEVALRWCVHHSKLKMRSEGGNDGIILGISSYEQLVQNVEACEKGPLPQAVVDVLDKAWERTRGDAATYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCU7</accession>
    <name>A0A9P4UCU7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_430044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCU7"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="6">
        <location>
            <begin position="93"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2447109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="232" mass="25172" checksum="3398A500A0D5D99E" modified="2023-09-13" version="1">MSYDPNHPQGGPAGAQPNMNISFNQMLQRSQQDQRPQEAPAEAPGHPAQAIGYRGVYNATPPPQQLPPNALGGARAPSAQPILPVDLPPQAFLTSSMLLDMVDKKVDVLLRDEKEYIGILRSYDQFANLVLTECSERIAARNPEASTDSPTPKWLICDVKLPGLMTIRGENVTICATVDLDREDEPKGVKFAPEEEVRELANAQRNQKKASEGRKAKAFKAAGIEAGFGMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCX2</accession>
    <name>A0A9P4UCX2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_454154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCX2"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000037">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="518"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="628" mass="69595" checksum="D2B1EAB911B5D929" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD96</accession>
    <name>A0A9P4UD96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_286586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD96"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="183" mass="19920" checksum="8B16BE6DF9C8D7D2" modified="2023-09-13" version="1">MQSCASVATIANRNDIAVPGSLPETIPARCSSVDTDTTRSIITRSDTTRSDTTRSDTTRSDTFNAPKRAGTDPYSSRSNTLNAPRRCGTDPQVTRETKRSNTDFHLALNGLFGFSEDQEYQDRRQLRLRSNGPRNTRKSMHSSDSGSDLRSDASTGKEIVYMEGGGCAEEVEAGSQSCTHLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDE7</accession>
    <name>A0A9P4UDE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_430446</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDE7"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="221"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2446256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="465" mass="50095" checksum="A15730E3CE8A09AB" modified="2023-09-13" version="1">MSESTLFSTPEIASHSTRDDCWIVIHGKVYNVTEYVRDHPGGVDVLIDMAGKDATEGYDDAGHSEDADEIMQSYRIGIAEDSNKARKTKAVKLVQQSSPLPTNTRTSPAATTALKAVLASVAVAAPAYYASQRGFFSQIPFDKVPSLALVGGASGNPQSPFLKGFAIATFLSSIAFVVAGKELAKFAHVEEGFGRHPPYRKAQPRVAPANPHLARGFLDAKEYKPLKVAKITKLSSNVFKYTFGLPAPRDIIGLPIGQHVAIKATIDGKTVTRSYTPTSNNIDTGVLELVIKTYPDGALTGKYFANLKVGDEVLFRGPKGAMKYTTGHCKNIGMIAGGTGITPMYALIRSICEDPRDTTSISLVYANRTEDDILLRSELETFARRYPKNFKVWFMLDSPPAGWTGGSGFVTRDVMEEKLPAVGPDTKVMLCGPPGMIGAAKKGLVELGFKEPGAVGKMADEVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE64</accession>
    <name>A0A9P4UE64_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_245537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE64"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="220" mass="23537" checksum="1D3625876D9A2C5D" modified="2023-09-13" version="1">MQEPPVPSGGLRPGKGTGALSSEHGMPPSASGASCTGGEAGRRRRSRSRRWPVMGEGAGAAAAEEGPVVKPRDDMVVSWCAAASEPCHGVRMGCDGHRRRRVCAVCPWHVHPLGTTARITMMSERYDRLRRSAPSTPPRPTTASLRAPSPRAITAALPATAREHGVAAAEWHCLRCGGRPASTTQPHNHTATPRRPPRNRSARQPARQPSAEPAREQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE76</accession>
    <name>A0A9P4UE76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_484584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE76"/>
    <dbReference type="OrthoDB" id="3763763at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="312" mass="35851" checksum="0118DE41CDA7EB33" modified="2023-09-13" version="1">MRHEATVANSSSRLLSLPGELRNKIFKYALTADDGIIYAYHFLGADHLYLYPRRPGHQTEGDLTRFSGPVLFNRLKHVCKQIQEEVKDVELKYNTVDYPYYADEEHRYPDDFIRLLRSYPQQYSWLTSLRLHTTPNILFGRRSGHRHDGFADIGAYLAPLVQFYKTIPHIKIHMVIANWMSDPTSLANVALGSSIVAACGLDAMTNALFNHPCYSMWGANKIFCTELIKEREKSGLAGACDGLDNLTFFPDMTDEEVEHMETTQGEQFVSRLPPQHPTLPHYEEWKKVWARMAVSWARHGIKPFQDEGSWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF25</accession>
    <name>A0A9P4UF25_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_471454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF25"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="41"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="583" mass="65595" checksum="B0C5019640C96296" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG52</accession>
    <name>A0A9P4UG52_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_406983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG52"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2448790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="294" mass="32123" checksum="34AB16B0FDD0E7E3" modified="2023-09-13" version="1">MSRFYIDDSSSPTSPTHPTSSNPSDSDSENDDTLPYPAPLSRTPFLAPSFTPQSYLSTLSNRHQTLEDLRSDLRARSALLSRELLDLVNTHYTDFLTLGASLRGGDEKVEEVRVGLLGFGKEVGTLAEGVGAREKEVAALVRERERVGRGVVVGRRLVGFEEGLKGVEEGLGIVEVAGSDSEEEDEEEDEEEDDDDDDEEEGVVGGVSIAKLRRHMLQWRVVREAEKGLAEHPFVVAQAPRMAKVRSMLLLDLSTALRQAKAAGAAGRVMRIMKVYADMGEEGEAVRVLKGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGF5</accession>
    <name>A0A9P4UGF5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Emopamil-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_353863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGF5"/>
    <dbReference type="OrthoDB" id="5415655at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="62"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2448192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="274" mass="31210" checksum="068712884472E2AF" modified="2023-09-13" version="1">MGLGFWGSKAAPPPPPPPPPPVHSSSLQIDATTVVSLLFFLSLLGAAYAGSVRFLPSTSTKKTRVLFVWHLFDALIHLFFEGSFLWNCFFVSYSLPTTFNVAARKHPRIKLLTPPDVYWLGREDRIYGASYGEGLFSKLWQEYAKADRRWGGTDLGVVSLEVLTVFVGAPLALWICWHLRRDERKGALKRWFWMIMLATAELYGGWMTFAPEWFTGSPNLDTGNWMYLWLYLFTFNGLWVVFPVWILYEGYAAMSSAMSHAEVVDLVNYLNKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH33</accession>
    <name>A0A9P4UH33_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_478783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH33"/>
    <dbReference type="OrthoDB" id="5357734at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37576">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37576:SF2">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="675" mass="74093" checksum="D6C3F3F50680D596" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH81</accession>
    <name>A0A9P4UH81_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_479461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH81"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040105342" description="Acid protease" evidence="1">
        <location>
            <begin position="24"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38525" checksum="7904034FEA6E2E05" modified="2023-09-13" version="1">MHVLQPIFITLVLAYSQIKGVLGIPGSAAPLVISSSGGWDGPDGPWSSFDLGAGSNIQAFRGFPALSQSLYILPHQTSWCGGTDQIEICERRGSYQAGDSTSWKEAGVYDLGDDLSPFTLSGYPPIAYLGLDTIIWGKTSIDPQFERQWIAQIVSEDFPMALIGLGTGVYHLPNGTDGGDVTSPIVGLRENGTIPSITYGYNAGSFYRNQTASLILGGYDSARIKNLSASASFSMPSNQNTTLIAKISSVGLNTNLSGNPTELDTPFLARIESAVPQFYLPLNICHAFEEAFGLTWDSTLLYYTVNESSHKINIQRNSSVTFSIGENDQVTKLTFPYQAFDLQLSYPLIKEVNTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH86</accession>
    <name>A0A9P4UH86_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_439041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH86"/>
    <dbReference type="OrthoDB" id="10542628at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="458" mass="49549" checksum="19D500CE043EA930" modified="2023-09-13" version="1">MSSNRSCECTYRMQFQHAVSTDPPGSIPSLYSPSEISKATAPTNKPETSRQTPGDGVLIEASSIVNKPRHEHAPPKEALDAAKTSYQPSVGTIHNRATDGSQLAMPELGEWVVEEITSDDDFESATWSDAETDIDGKAHASSATLIAPLKMSQVKVKPGIEGKASAPDAALIASPTTPQVAAKNDVNGKAPTSEPSLIVSSKTLQGVAMEDIDGKPHATNAATVAAPKTRKVTVKQDKLISSSKVSNIGVAPGKSPDFNTATNASSKTSEVEVKRYNIFSDSELRHTFEEAMRKTFPTNIFNAMLADLKGDAALDDGTSEEKTIRRVLDGIDESHRNIGLSTLAELYPKWLSKPKAEAEVKVKTLKERFADLTVKREPAELDQRGEKNTPAKDTAKDLVQAGILLKSSVDRGTTPKKPFQDVKLRYLELSPKARVPVSKDDKENADPKAKLEREKNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHG5</accession>
    <name>A0A9P4UHG5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_450879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHG5"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF34">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2450200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34878" checksum="195A67C0D843D89F" modified="2023-09-13" version="1">MGAGDPIPLSLYIYAPNKVAPILFTFLYAISTAIHLHQCHRDTSWRLLCLLPLSALSFTLGYILRTANAFDAYLYSPSNPTNLIIFILTQVFIYIPPPLLELANYHILGRLLSYVPSCSPLPPKAVVRVFGGVMLAVETLNALGVSLSANPTAGEATMKLGKGMAFAALGLQLGVIVAFGVLAAMFWVRLRAAGVRVRAVETALRTLGASMTLIFVRCVYRLVEHVGNTEADLGDVEKLRELSPVMRYEAFFYVFEAVLMLVNVGLWNVWNPGKAFSRHVWTADGSACEAVNSISRANIIWTPHDQRYSSPRGLVSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHM5</accession>
    <name>A0A9P4UHM5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxysterol binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_451650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHM5"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="215"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="884"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="986" mass="107842" checksum="15B97CB9750F2CE1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI93</accession>
    <name>A0A9P4UI93_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_425962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UI93"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="846" mass="94326" checksum="B020CEE384528E97" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIM7</accession>
    <name>A0A9P4UIM7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_426332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIM7"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="450" mass="50304" checksum="997021A266143D67" modified="2023-09-13" version="1">MSSEDAFRMPNFGDEEPGARESGDLGSDDVGHDQVVFQEPNFDGEHHQEHPHPEHTADVPPESAANYVMIAKGADGDADLVEDPSSNKRLDSEAKNDTLAHNPSLELAPTQSIAQGEAHKVVEKRTYLHKKHSERIQRHTFLAKCLGVVQNIWSMVSTFPYWDMAFWSGFAYAVGSAMFIIDGAFAFGPLASPNKHWPEGEDKYAGPMLFFLGAVICYQTGAVMAYLEAINDGCFAGVAMKRFWIEGSEEDKRKLLDAKLHTFFGHIIPHHHHNDSGDVHANDMIGEKTRADTGGEQDIEAMRRTATNREPEAQPDPLQPAPSRRQAVDHGLADQEGFHEYMTWRWWPTWHAFRTYHIREVGYVACSIQLLGATLYGVTGIVVLPGVLSSLAWWQKIAAFWVPQVVASVCFLTAAIMFTIESQDVWYKPIPWTVRWWIGGWAAIGSVGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIZ7</accession>
    <name>A0A9P4UIZ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_503564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIZ7"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF51">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="598" mass="67931" checksum="C1A2303EAD559812" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJA6</accession>
    <name>A0A9P4UJA6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_401032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057068">
        <property type="entry name" value="IML1_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24438">
        <property type="entry name" value="IML1_N_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="DEP" evidence="8">
        <location>
            <begin position="1370"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="779"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1470"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1712"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1477"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1712"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1772"/>
            <end position="1790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2451478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1927" mass="215130" checksum="CCC74FBA836DC6C1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P3S2</accession>
    <name>A0A9P4P3S2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_172271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P3S2"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="656" mass="73208" checksum="D480FB2EF9CF4EC3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4I8</accession>
    <name>A0A9P4P4I8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_372217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4I8"/>
    <dbReference type="OrthoDB" id="5387413at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="227" mass="26295" checksum="B1DBCBC0EFAC2DB2" modified="2023-09-13" version="1">MSSKLSSGSKKERNVGFMRDPVSAVSRPVNTDESWAAHHFETHAHKCAYCRNPYEVHRNHEQLCEIGHRLAQDVASFLYQRADGKTYSTVEEDNKLVQIEVPSGFVQVRSLLKAIERSLRHRSRAPFVSMDRTYYVAARMPVRSHSVKVDQEIKHKSRPRSGEIVEWPSSSKPQKATVAVDKSSSKRGSLYEQDLELQRRNAKNYKIEVREPSPRDRREHRLSGYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4K0</accession>
    <name>A0A9P4P4K0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_373923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4K0"/>
    <dbReference type="OrthoDB" id="3783825at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="33"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2437235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="354" mass="39240" checksum="27FE85B7B3680EBA" modified="2023-09-13" version="1">MPSSELPVAFVNAREIVAATITLSISGIIVVLLRFWVRVSHKMCIRADDWLILAALVFVVAMAAVSLYGASKKAVGYPSVELPPEEQMTSLSPEQRLVELTYWLSWMLMLPATGCVKLSTLYLYRRIFPVDTMPTFDVVSKLLVVLCALWTVAFFFSNVFGCGIHFQCAWASFAEVSTCCTNKFLNRDVLLISDLITDVMVWSLPIPVVCGLNISIRRKLGAVAIFMLAACSLAAAVVRLLIQLRLHKRGLMAWKNVNLTLSTTLYWLFIEADIALIACCLPMVPLLFDLIPISRGLSSLRSKLGMPSAPSQTETQGSEDELCKRSSLSIHIEHAFDLGSEIVLPIRSRDDCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4T3</accession>
    <name>A0A9P4P4T3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_183003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4T3"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="290" mass="32034" checksum="53A0D1ACCA8456B1" modified="2023-09-13" version="1">MTFLTTITRFLALSTGESIFYREAGAPTSPTILLLHGYPSSSHQFRNLIPLLAPEYRVIAPDFPGFGFTNVSTSYTYTFDALAATVSTFLSEIHDPPTKYAIYIFDYGAPVGLRLALEHPDRISAIITQNGNAYASGLGSFWDPIRTLWNSNNSGPAREALVPFLQSGTKGQYTDGEPDPAALDPAAWTLDQALLEREGVFDIQLDLMYDYRTNLELYPKVQEWFRESQVPLIAVWGRNDVIFPPVGAEAYKGDLPGAEVNFLDAGHFAMEWHTGAVAGLILEFLGRKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4X9</accession>
    <name>A0A9P4P4X9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_180485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4X9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="121" mass="14218" checksum="6AC3B872362A0892" modified="2023-09-13" version="1">MSNVRLVIRSLGLDLVSSEPSGEPLERERPHYFPGKPKQLQVDVCCSTWLERCRYQRRIVISEISCVCPYVFLAHALRPSIIYWLVWSDHIPRAARIMATDWHRQYQFIQSMSCITAKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5J4</accession>
    <name>A0A9P4P5J4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_458424</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5J4"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2438774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="357" mass="40557" checksum="218B00CF50F70770" modified="2023-09-13" version="1">MTTMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVLDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGSLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGFPNEFAIYLNYTRSLRFDDKPDYSYLRKIFRDLFVREGFQYDYVFDWTVYKYQKNAQAIAQAAGNQGQGEEDDKARGRHVTTTAAANAGTGTGTATKGGRPVNARQEGTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5Z0</accession>
    <name>A0A9P4P5Z0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor 5A-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_490451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eIF-5A family. Hex1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5Z0"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140266">
        <property type="term" value="C:Woronin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04469">
        <property type="entry name" value="S1_Hex1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000033">
        <property type="entry name" value="Woronin body major protein HEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037318">
        <property type="entry name" value="Hex1_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Translation initiation factor 5A-like N-terminal" evidence="10">
        <location>
            <begin position="625"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="557"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2438999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="772" mass="87424" checksum="F55C30DF92CE7ED1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P636</accession>
    <name>A0A9P4P636_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_130858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P636"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="101" mass="11623" checksum="B85DF952B04512B6" modified="2023-09-13" version="1">MPKYSPLVARFMPRQLLLPRPKANRFFLRSGLSSQRCVEMTWALDISSDDWPVFFVELSELETALVFVGVHVVVELVPEGQSRELVELELVDHQCYSMDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P650</accession>
    <name>A0A9P4P650_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_448597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P650"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040318613" evidence="6">
        <location>
            <begin position="18"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="493" mass="52723" checksum="9CEFB9995773B249" modified="2023-09-13" version="1">MLAAVLKAFFLAAVASAAAVGDLSKGLRPKLAQAAEIYTPGTPAFDDAKTRWAANINPTFDAIVKVTSEADVQATVAYANAQNVPFLAFNGGHGFSKTLNNFKGGIGINMRGMKKVTISNERTSKGPVAYIQGGAKSGEVIGTAWAAGKTLVAGACDCTGFTGVTLGGGHGWMQGQYGLAIDNVVSYRVVLANSTAITVSAASNPDLFWGLRGAGHNFGIVTQVHYQVYDRTTPADEGFSTKVYIFTHDALEPLFTLLNTWLRAESRPVELTHFGVLLNIPAISPKPIIQLLVFWQGPSFPRKYSDPLDALNPYSVTSNYTDLAGANALVGSNLDGPNCAPGFGRQTFPVDLVEWSPANLRTVLNLFAELPGTGLDTSAMLLEAYAVNGVKLVDAASTAFPLRHGNILAAPTFTYDASNATQDALAYSYGKKVREAMLAGTGQKLGAYVNYAIGDESNEAVYGYEEWRLERLRGLKKKYDPQGRFGFFERIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P651</accession>
    <name>A0A9P4P651_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_527081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P651"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2437201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="301" mass="32902" checksum="A5DC106353F0C537" modified="2023-09-13" version="1">MPQPPLRRILVSGATGKQGGALIAALTAHPTPPFHIYALTRNPKSRSAQALASNPNITLIQGDFSNPPAIFAQIPHPWGFFSVTNPLNAAREEAQGKAMTAAAIAAGVSHIVFSATDRGRDADTDATVVPHFASKFRVERDIVARAAESGGTYTILRPVAFFENLSDDFLGKGFVSMWRVNGVGSRIKFVSTRDIGRVAAEAFVGAGTEKYRNRAVALAGEDISLGEFESVFREETGRRLPETFGVVGRGLRWALREQLGIMFDWFESEGFGVDVGEVRGTYPFLKDFREWLRTESAWRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6F3</accession>
    <name>A0A9P4P6F3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_399945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6F3"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="355"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="678"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="845"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="800"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="898"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2437598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1002" mass="108863" checksum="FECF23B8862E2D5F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7F8</accession>
    <name>A0A9P4P7F8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_371198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7F8"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF7">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="72" mass="8278" checksum="0C7BC3284F536E7A" modified="2023-09-13" version="1">MLDHCLDILRSATLCHGDTTLTTFGWTNKSKPQLNTRPINHQCVDWKKVEASVEDRVVQREEVEAMVNLNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7G6</accession>
    <name>A0A9P4P7G6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_504214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7G6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="168" mass="18781" checksum="E2A2E985DCEB5951" modified="2023-09-13" version="1">MDYVDEGCGGSIHFDALLQSATHTWDMAVKLANGPRRYKCSNGRELHVSAEDMRSVASDEWMRGSLVNVFASIAVDTSAGPRKLRVVEDPPAATVETQMEDIARYPLLLPICEKHHWMMFVFHLDTQTACPRFSEITDILVLTATCSVAVMTRMPTPKPRVKKLVCIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7P0</accession>
    <name>A0A9P4P7P0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAT family amino acid transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_458838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7P0"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="135"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="523" mass="57981" checksum="03E7E9F3D6808626" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7P4</accession>
    <name>A0A9P4P7P4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_436691</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7P4"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2438777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="385" mass="42450" checksum="C0FE0C15395CAC14" modified="2023-09-13" version="1">MAGDAPAARKCSGKDCDNDASQLQCPNCQKQGKESYFCSQDCFKRNWAEHKKSHKSQTTGTFNPFPAYPYTGPLRPVYPLSERRKVPASVQLPDYAKDGIPHSEQKFVGRNKIAVLNAKEIEGMRKVCRLAREVLDIAAREAKPGVTTDYIDEVVHKACMERNSYPSPLNYGHFPKSVCTSPNEVICHGIPDQRVLKDGDILNIDVTLYHGGFHGDLNETYYIGEKALADPDSIRVVETSRECLDKAIELVKPGTLFREYGNVIEKHSKAQNCSVIKTYCGHGINQLFHCAPNVPHYAKNKAVGEAKPGMCFTIEPMISLGTHRDKTWPDDWTSVTADGTRTAQFEHTLLVTEDGVEILTARLPDSPGGPVARIEASNGTVAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7T1</accession>
    <name>A0A9P4P7T1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_399197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7T1"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="316" mass="35554" checksum="F6B9703B91A42054" modified="2023-09-13" version="1" fragment="single">MVKIALAGGSGDVASEIIEVLVTTQKHDIIVLSRSSKPKREAPTGVTLVTVNYDDAEQLVHALQGVHTILSFISEGEDPQSPMQRKLIDAAVRAGVQRFAPSEWGPSKLDHLDWYAYKGATREYLKEINKDKKILEYTLFQPGFFLNYLTYPHASTKHLHLMDTPFNLNDRRFITLRGADESRVNWITVQDVAQMVAKAIDYEGEWPIDGGIKGTEISMGNLVLLGEKIRGGTFDVTKLERSDLLAGEWKASWAPVIDHPSLKKEQLEPISKHISGRILLAIEAGGYVVNNMWNRLFPDYDFTKLEDYLTQAWEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7U7</accession>
    <name>A0A9P4P7U7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_158540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7U7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="110" mass="12926" checksum="2695048CFA112B20" modified="2023-09-13" version="1">MRVERFSPPRNKCDMTILTCSHYRFNRRLSLRNCDCLPHSVLDGEALWKFRCAYALVTGGVSGIHDQIPCRRDYDAWLWNDSATVPQRFLTDASTRKNYPQLRNYVQDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8H5</accession>
    <name>A0A9P4P8H5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2264 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_475860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8H5"/>
    <dbReference type="OrthoDB" id="5150166at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF4">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="161"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="779" mass="86319" checksum="3B7A835B63AD1DB0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8P1</accession>
    <name>A0A9P4P8P1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF862-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_436987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8P1"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="153"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="300"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2438521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="606" mass="66012" checksum="7A4F05AD3AB86AB4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P942</accession>
    <name>A0A9P4P942_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_395680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P942"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000012">
        <property type="entry name" value="Transketolase, variant 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="381"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2439756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="712" mass="78552" checksum="97686E53BD89F21D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9B6</accession>
    <name>A0A9P4P9B6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_458232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9B6"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="323" mass="35660" checksum="F4BFA1215EAB7CE6" modified="2023-09-13" version="1">MLFPWKIFALPGFGWFVANGTITIVSVALVQREFNVKRIAFLTVANGRRIAFNMTLLISSVAGFADAGSPRFVTVCPVDLVMLLFGQAIAILVGWPLIANYSCPSTTPKAYWTFGGPTLVMLLLRLFLGNYEKRSQAEWITPSCFEAIYAQPTIACSNNPVTKAPSSNIVKRSIAKVHPEKIKVLFLTPHFALNTTLLIFFWCSIGVAYPLYNSFIPFCFENKGVERAPHPSLLWNFGFTLGGFTVEMKCVGRKGTGTLACLCAGLILSLFTQAKSSASVLGFTCNNVFFQTLVYGLLYLYTPECLPAPVRRMRELMASIIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9V8</accession>
    <name>A0A9P4P9V8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_436005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9V8"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="682"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="858"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="898"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="189"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2439308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="930" mass="105685" checksum="3A4100003EF3C6CD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAL0</accession>
    <name>A0A9P4PAL0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_476790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAL0"/>
    <dbReference type="OrthoDB" id="3800309at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="445" mass="48598" checksum="0C7FDAF59093A30B" modified="2023-09-13" version="1">MDSNKSDPSPSDIAELQRDCHPFPAYIDYMQGRPTEYERLMENLELAVSDDQDENRSFPQKLAMGNPMAPADGSGVSAPYKYSDPPAPVPAAGSYPSPQSMHAAPPSSMLGNTMTSRIPSQPPGLRMNKQSRQNQQSRQKPSLFGSSTTTTGGGLIGGAQQNHVHISGAFGQNKPGGLQRLNAHYGSPPSLFAAGPGPTQLPAGGQANRPPMMRTNVTETQPQPMVMGTSQSEISAPLSAPPTNHAPKTSSASAVPKPPVLILQRDDLLKPAFNWMPQQARASTNDKVGHLRDIIASGDIPMSTRNSARIELLSLGAQVTEALFMLIHLRLLRNIHQTMPSLYDAKMVTRHYPNDHPENIKANGTIQRIRQQFSGPAQDYMKRLFEEMIKRASQGKMAYEAIPGWLEQWNREHAPKAPKENAAVQEVEMKQSKGESSPLPQWRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAN5</accession>
    <name>A0A9P4PAN5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_99404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAN5"/>
    <dbReference type="OrthoDB" id="433414at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017:SF0">
        <property type="entry name" value="METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34274" checksum="B2C9A6003AA566BB" modified="2023-09-13" version="1">MTAPHSLPAERRRIIWHRVYKELLKHAKPDSRFHYDFLSFTPDFHGSSAAVDRLVQLPCYQAATTILATSDGSLEELRYRALKDGKKVLVGTYRLRRGFVLLSPQRIPEAELRVASWLDGMERPGIGRHLSLAQLQEEGIKVDLCVFGGLAFNTQGVVVWEGQGLFEVQWALLHDTKVMREQVPVVAVAHACQVVDEAELGLERIKPEKAVEVQCDYVVTPEKTFEVQDAVKPSSGVDFDAVDAAALENIPPLQELKGIRMMESIMKEGGFKEDKKEEQGPTAEELTGIDMMEKIMKGFKDKTSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBD2</accession>
    <name>A0A9P4PBD2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_456798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBD2"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF3">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27605" checksum="BC571E68AD48EC9D" modified="2023-09-13" version="1">MNCPYQLSETLTLQPCNKANSPCLMELFRLRTTPTPVYNGAQPSVPKPDTELQVIGAGLPCTGITSFSGALRILLRDPVYGHRSMRRKTSLDTAVNTLLVESLAGYAAVTEMAAAGLVKDVLELYPDAKVICTVRDPDAVANAATLWFLGVLLLPHPRMRHFPSYIDILRKQCVRLYGEHDPVKTVPAERLVFFTFRKEVPSVPFTNINDENVVDGLVEEMVKEGLTKRALVLVTIGVGVVLLLMMRKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC60</accession>
    <name>A0A9P4PC60_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_106233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC60"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="177" mass="19147" checksum="CDC20D8D1F24D5F4" modified="2023-09-13" version="1">MHNSRTLHSMYTTESTWRDVPCPPPPAGPCLEDSDLFKARNHARNRQVESTASSTWLTWIPTFANPTRHLPVASGKGDKQWTSPGARGGAVATLSALCLHPISRRPALSTLPSQSRTESPFLQFIGSDAPIGLWSAAAPVPISDCPCCLIGCLLVCGRNTPVESMMFSALYLARAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCT0</accession>
    <name>A0A9P4PCT0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_86773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCT0"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="157" mass="16800" checksum="577CB6B844A212A4" modified="2023-09-13" version="1">MLTWNSGFKIQLQAMLIDTSFNSVPTVLANLYQSFHEAAVRCFEYARSLSKARPIHSSLLISTVASIMALAFVMLQRRTRSRAAQNAEKAGIEGFPHCVSAQTDTAPHSAGVPPKRTGGSPTASQCGKAHARGRRPLGVHIIQRADGSEAGGVQVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD64</accession>
    <name>A0A9P4PD64_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine deaminase</fullName>
            <shortName evidence="7">ADE</shortName>
            <ecNumber evidence="7">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenine aminohydrolase</fullName>
            <shortName evidence="7">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAH1</name>
        <name evidence="9" type="ORF">P171DRAFT_50951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="7"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD64"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000039">
        <property type="entry name" value="Adenine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF6">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2442854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="353" mass="39399" checksum="D3C0D40B9C0B07EA" modified="2023-09-13" version="1">MPGSPVRDFLRCLPKCEHHIHLEGALTPDVLFSLAAKNKITLPQDDEAFKSPALLIERYKRFTSLDDFLHYYYIGMSALVTASDFEDLAWDYFQHASADGVAHAEVFFDPQAHTARGIKYTTVLEGFDNACKRAERELGITTLLTSCFLRHLPPKDCLELFEDEDVQESYKSGVVRAIGLDSSEKPFPPENFTELYTKAKALGLKLTAHAGEEAPASYISSALHNLGVTRIDHGIQLVNDPELMQKIASDKTMLTVCPLSNVVLRCVDTIKDVPIRKLLDAGVQFSINSDDPAYFGGYILDNYVAVHEAFALSVKEWEGVVKAGIEGSWCSAERKEELLQRLNRVIADWEGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDA8</accession>
    <name>A0A9P4PDA8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_362921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDA8"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000050">
        <property type="entry name" value="Dual specificity phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="30"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="165" mass="18482" checksum="6DB1A2ECBCAA85E8" modified="2023-09-13" version="1">MSNITLGSLSYISCEELAEQLHASPLAPSFPSNLAIIDVRDSDHVGGHIRGSTWVPSNELDYKTPELVRNLKDKDVVVFHCALSQQRGPSAALRYLREKERLDPGSKSVTKEGEEIKEGGNKEDGGEESQKVMVLRGGFTQWQEKYGPDKTLTEAWQKDIWEFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE27</accession>
    <name>A0A9P4PE27_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_433916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE27"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="45"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2442411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="174" mass="19408" checksum="485A95F147CEA558" modified="2023-09-13" version="1">MDDEPQDQPAQVAIEPPTFKAPRMVSRPKPQQQEEEEIGSELKLGDFEGEQPLSISEARAVVTAVHEKRKLKAAEGHGVLGDRTHNDTQSIQQFVDYLEMFARYKELNNLTAMGGVLDANPQFTMAERAMLGSLCCDTADEAKTLIPSLASKMDDDSLQPVLDELQKYQDRLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEP5</accession>
    <name>A0A9P4PEP5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="7">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_42221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEP5"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040234205" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="4-O-methyl-glucuronoyl methylesterase-like" evidence="9">
        <location>
            <begin position="117"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2443665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="404" mass="42914" checksum="5DE66B6CC57BCCC7" modified="2023-09-13" version="1">MHLTYIAFALCAATVSGAPTPGSSFSQLLDLLPRQSNVTCPKTPSPMPKAADLPAVKTMPDPFLYLDGKTKVKSKDEWYQCRQPEILKLLQEYQYGYYPDHSQETVTATRSGTKLDVTIATGGKSATISATLNLPSGSGPFPVVIAIGGIDNNSYLKAGIAVVTFDYGKVAADSNSKTGSFWTLYSGKDIGVLTAWAWGFHRVLDGIELKVPEIDAKKSGVTGCSRLGKAALAAGLFDKRIAVTMPMCSGVQGAGPYRYSLSGQGENLENSKSGAGWWTSSGISQFVNHATQLPYDAHTIVAAIAPRAVILEQGASDQFTDSKGTATVTFPAAKAVYSWLGVGDQLGMSIPKGGHCDMGGYADVLPFVQKVLQGKTTNRNYDDLGSWKAMPEAYPWATSLPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEW9</accession>
    <name>A0A9P4PEW9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_60913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEW9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040173595" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8907" checksum="BEF27C78B6A8D3D0" modified="2023-09-13" version="1">MGGLWVRISLMLGRGGWGCAWITLYGAREHVSVSAPAPACSNPSSRARRGDRLFLVQLFSFAHMQGMEYGQLSQGHPRLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFJ0</accession>
    <name>A0A9P4PFJ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_496364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFJ0"/>
    <dbReference type="OrthoDB" id="3685058at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="114" mass="12739" checksum="24CC2CC4AC182953" modified="2023-09-13" version="1">MIETFKDMKHGKSSYESLKLERTASELIHRMQETASEDSLESSRARVLANAKAIYGPARCLDIITYGNTSSRKIAAAIVEHNPTGRSYIHCCSAKEDTRLAALEHLLVIQEDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFN1</accession>
    <name>A0A9P4PFN1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integral membrane protein S linking to the trans Golgi network-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_414002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFN1"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2444175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="21978" checksum="A75B485319D23C57" modified="2023-09-13" version="1">MPRRRRPPRPGALADLSPTRIASQIVLLQLAYYACAAVLIVFTALVFGKEISTDLLFSWRSLRGDTTVGWTLGLVWVLNSLTCAVFILLLIARSKLVLDFALTIHFIHLVVTSLYSHAIPTNLFWWALQACSAALMTSLGVWACQWRELRPINFGSKTVARQAAGAVEENAGESRGRGRGRGRDGAGDYEMVGMAGGDDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG02</accession>
    <name>A0A9P4PG02_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_64137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG02"/>
    <dbReference type="OrthoDB" id="4148662at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="412" mass="41190" checksum="CE6CA4CA37A78D5B" modified="2023-09-13" version="1">MSDLDIFVSNGTCYTKAGEKLDKSFIPCGNSAFGFQTCCGAGDNCLADNACFGQHGDGYGSQLTYQAGCTDPDYKDKSCPDKKGIDQPWIALTRCDDDDSVWGACSQEGNPSTLQPGSFCSCTEVAKFTPSAFSDSPSLALFAVLPTGTGESIKFETGHVPTGDPTSDSSPAETGSASAGGSGTGGSDPSASQTGKGSATQGGSGNNATPSHTGAGLLSSGTSSGSDSLSTGGGSNNGGSNNGSSNDSSSGLASGAKIGIGVGVAVGLLLLIAIIAAILLRRRKRRRTHATAAAAEVEKGDRKDASPLAGAAAGRVSDATGADPRISDVTGATGATEKTNNISEADGKPLSGAAKPGVTELDSEAVMEVSGHTAHPWDRGAELDGRQLRKPSSPKELPGTLAGESPPSWVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGN7</accession>
    <name>A0A9P4PGN7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS peptide transporter-like protein Ptr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_464280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGN7"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2443577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="613" mass="67664" checksum="7545C32A987987AD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGQ2</accession>
    <name>A0A9P4PGQ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_412563</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGQ2"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2444760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="136" mass="15237" checksum="1E9D52070003FE0D" modified="2023-09-13" version="1">MAHRIITQVVFTGVRIIGRAVSESYRQAAASQKYAAAGQQAGGGFSSSTITMDEACQILNVGPSKMGQIDEAFVTERFKRLFDLNDPKKGGSFYLQSKILRARERIEREVQGFKQMAEREQELSEGFKPKWTKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGV8</accession>
    <name>A0A9P4PGV8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_464392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGV8"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="274"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="756"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2443775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="816" mass="90415" checksum="F1E32119798D4124" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIL3</accession>
    <name>A0A9P4PIL3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_513752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="38"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="604"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2444677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="694" mass="77755" checksum="16B01E0FA5380D8B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIM1</accession>
    <name>A0A9P4PIM1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_23781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIM1"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="99"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="427"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2443998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="62272" checksum="A903A7975674E959" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIR9</accession>
    <name>A0A9P4PIR9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centromere protein H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_359631</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIR9"/>
    <dbReference type="OrthoDB" id="2274804at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="8">
        <location>
            <begin position="44"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2444810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="242" mass="27013" checksum="EA4C615DFD2C95E9" modified="2023-09-13" version="1">MATPNHVLMGDGATAKAIDANDYTDLLQTPHSDAFAFSETEQFALQLYDQLRELELEKSLLEAHVKDDVLHEHLMTAEREALEAKAKLEIRNRISHNVLIMDPVLKAVHGGQHHTVEKRLLPLISENDALSMVHGMLTTKLANTQRALSVAERGNIVLNEENRDRSRTVLRLAEEVKAQSIEDIGNPSLREQVEKAEKNVKESRKRTATIKGILSAMIVGSGINWAADEELRELVMDDEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIY1</accession>
    <name>A0A9P4PIY1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/FMN-containing isoamyl alcohol oxidase-like protein MreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_472934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIY1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040452800" evidence="6">
        <location>
            <begin position="20"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="152"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="650" mass="71609" checksum="6C2893EA97ED675B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ75</accession>
    <name>A0A9P4PJ75_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_412966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ75"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="347" mass="37767" checksum="19EA24CCABCF8D29" modified="2023-09-13" version="1">MSDVTIQPGTTILVTGVNGLIGSYIVGSLLKKGYHVRGAVRDVEKSSWLLDHFNGTQDAKLDLVSVPDMTIEGCYDDVVKGTSGIIHVASPLSGADPESTIPIGISAALNALSAAAKTPSITRVVYTSSSIAATFPTYSAPKPLDQSSWNEEGIAKGWQHPADEPASRKGLYIYAALKASSEKTCWKFMHEEKPGFVLNTVLPNCNFGRVLVPQKQGAPSTIEWAKYAWEGANLEAVTKIITPQFYISTQDSALLHVAALLNPAIASERIFGFAERWDFNKLLAVYRARYPERQFPADIEGLVDDKCVPPSERAEEILKWIKDDGKGWDTLEDMAGEMAEQFASGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJM5</accession>
    <name>A0A9P4PJM5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_485968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJM5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="197" mass="22372" checksum="B48416F6E1FBF35D" modified="2023-09-13" version="1">MLTYEEELRWKFADMAKACLTFVPENMAETVQAAKALVSVTTGEDPKLWTKIPKDECPFTIRTRLFTLVHHVLGNAQAYFVGELGSEAREVEGLKGAFDALREAAHRDLLRQHIQLGDSMAVRLGVANLSTDTAEERVRELIEQSAYPRFKRQLKRKRNLKDEFDGYDAGEHEPGESNDEPRPKRTDLGNNGKDRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK75</accession>
    <name>A0A9P4PK75_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-ketoacyl synthase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_359015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK75"/>
    <dbReference type="OrthoDB" id="3934956at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-ketoacyl synthase-like N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="84" mass="9032" checksum="0A7698E767567174" modified="2023-09-13" version="1" fragment="single">NLVLTPESFAGLSNLGVILPVGICYAFDGRANGYSRGEGIVCLIIKPLKTTLMDVNPVRAIVRDTGVSSNDRTSSITRPRLNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKE7</accession>
    <name>A0A9P4PKE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKE7"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="618" mass="68707" checksum="AD58DCC83D954210" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKH3</accession>
    <name>A0A9P4PKH3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_494958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKH3"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="304" mass="32396" checksum="1A0132B32BBF005A" modified="2023-09-13" version="1">MADTDWGSGGAPSFTKILFSDVYPAIDPSNTTLPTGFSVCVIGASRGIGAGIATSYAKAGASLIILAGRRTSGLEDVSQQCKQVGKVKDMQVQVVRCDLTIPSEVESIANQTRKICPGGLDVLALNSGVTEFVAKIIDTPTEQILNTTAVNYVGTFLVAKHFVPLLLGKDKGAKMFAVVGSMASLLVRGPIANAQYCVSKTAQLRLVELLHEECHVAQGLHVFCAHPGAVASEQSIAKSPEVFKPFLTDSAELCGSFFVWLAARGEDVSWLSGRLLSATWDVIELARRKDEIIANDMLKLKLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKM0</accession>
    <name>A0A9P4PKM0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_510824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKM0"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="222" mass="24513" checksum="4B0EF5492E5C04A0" modified="2023-09-13" version="1">MSLPRTFCLSSASAALTPSTALTSFTNHYEVMKLYPSASTEDVKTQFRTLRAEYFASDARRYRQLQTAYAVLVDVEARREYDELYRASTGLSAVVSESGGADESSRSAGSSGSARSALVKAAVSRIDAQTAEGKAEEARRCTEEELLRRVEEEEQRCAEELRGREADPNWGLKHFSPVYAPLIGSEPYHSFVPVAVDYEVGEVKRRARRPTYVGEIAAKAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLK0</accession>
    <name>A0A9P4PLK0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">chitinase</fullName>
            <ecNumber evidence="1">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_453705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="1"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLK0"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000159">
        <property type="entry name" value="Class V chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF378">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="363" mass="40575" checksum="6FBA9C2DDCD81B02" modified="2023-09-13" version="1">MYLTGQHPIVPSPRLVKDVTHVAMAFMRSEIFNEHGRDEWQLFTSVEETREKFAKDTKIMVAIGGWGNEEGFREAARSEKGRQKWAEGVRNMIDKTGADGVDIDWEYPGGNGEDYKRTPNSAHTWELTNYPLLLSALRAALGPSKLISAAVPGLPRDMLAFTPAYIPSIMASIDFLNIMTYDLMNRRDNVTKHHTGIKNSLEAIDAYIAAGVDPSKANLGLAFYVKWFKTDPVARRNCVAHPVGCPAALMEDPENGADLGKAGAFSWHDEVPAELKVSFDKALKEGTYDKDGYFYFDAEEDLFWSFDTPDAFRRKVSQIRKKRAIGGVFAWGLGEDASEFVNLKAANKAVQLWRGGRVDRTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLX5</accession>
    <name>A0A9P4PLX5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pre-mRNA-processing factor 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_382431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLX5"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="247"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="571" mass="61424" checksum="CB72BF7C73BA3E53" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM85</accession>
    <name>A0A9P4PM85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bli-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_386498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM85"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="29"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="204" mass="22011" checksum="0A723EF7A5F017FD" modified="2023-09-13" version="1">MSSYSNADTGSKQADPYTAQNKQEPSLKEKVEDLFSFIDKTKICLLTAQTAQSDLLTSRAMALAAKEDNGFDLLFHTNTESGKTDDLKTHPSVNIGFINNSGEWASISGHASIEVDRNVVKKHYSPALKAWLGDLGDGTHDGGPEDPRIGIIRVKASTVTYAVSNSTTLGSFVELAKGVATGQPPNVNKLRELTEAEISQWKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMU1</accession>
    <name>A0A9P4PMU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Soluble quino protein glucose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_408647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMU1"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF4">
        <property type="entry name" value="LACTONASE DRP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040452039" evidence="2">
        <location>
            <begin position="21"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="3">
        <location>
            <begin position="41"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="485" mass="50655" checksum="35FA137838D27AF1" modified="2023-09-13" version="1">MATSRLLALAYIALGVAVRAQSSTASASACASSIAPKNAAPSVASGWRAEVVANGLDGPRAIVFDSEGGLLVVEGKKGISRISFGKGEGGCARGEGDREVVLNHGLELSEDGKTLYASSSSAVYAWDYDASQGRNTSGPREIIGGFGSTAGHPSRTLLLSRTVPGLILVSRGSLENIDETTQNRSTGVSTIKAFNLTNLTDSSSYSFPDDGLILGWGLRNSVGVAEEPVTGAIYSVENSVDNFNRSGESIHQNNPGEELNFHGYLNGTQTDEQGGNYGYPTCFAAWNVDEIPDNEGVQVGTQVAIGEQNSSLNDTFCRDDRIPPRLTFQAHQAPLDIKFNPNGTAAWVTFHGSWNRDEPIGYKLSYIAFDGAGAPVANATSNSSTIDIFSNSDLSKCPDECVRPVGLAWDSEGRLFMSSDATGEIWVVTREDGSSAEDASPSSGLPPSVTESAPPETSSPGAATVGRVDVGLFAVVGAAVLAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNE7</accession>
    <name>A0A9P4PNE7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_246776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNE7"/>
    <dbReference type="OrthoDB" id="250836at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2447162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="220" mass="24649" checksum="C89FABCE571E22E1" modified="2023-09-13" version="1">MPSAADRRAKTGKKMKEQAKLALARKDSMMADASQGVIAPIVEIPHVFVDPNNNNAPDASQGAITTPVEALIGEIGKKTFKSIAAVFEYWADQPMEEDSIYNAADPNSSYHAEWLRHQRAFRKKDMKEYAPTSVPYNLQVAKENGIDVSSHLEEPASKNSRARDCLYWSLGTCRNGDDCRFFHDPTKAPKSGVVQSNVCWRWKKSMCFKTAADCPYDHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNU8</accession>
    <name>A0A9P4PNU8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_343895</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNU8"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2446553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="331" mass="37273" checksum="C4D5CF650CB6ABA0" modified="2023-09-13" version="1" fragment="single">RTIVSGIQPTGVPHLGNYLGALRQWVKLQDEEGHPHDKRFFSIVDLHAITVPQDPRTLPQRIKETYASLLAIGLDPQKSTIFVQSDVAQHSELMWLLSCHASMGYLGRMTQWKSKTGVADDADPLESAPNKPALKLGLFSYPVLQAADVLIYNATHVPVGEDQAQHLEFTRELAKSFNHVYAKKTRRQPGDRITFKGFNIPKTILSPAKRVMSLQDPTKKMSKSDPDERSRILITDTREQIQAKIKVALTDSIPGISYDRELRPGISNLIDIMYYMDESRYDSPEAIAQEMSSADLSMKALKEKVATTVADKLEPIRERYNEQMARSAEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPL7</accession>
    <name>A0A9P4PPL7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_511133</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPL7"/>
    <dbReference type="OrthoDB" id="6038816at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 19" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040233372" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2447058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="264" mass="28012" checksum="2BB4DCBAF2665091" modified="2023-09-13" version="1">MRWQSTFATLIAISSIALAHWNYESVLLNGKDPGAYQYVRSPKNSNSPVTDISSKDMVCNAGGNDADVLAKTKSLSVKAGDQVGFRINSVFGHPGIQQVYMSKAPDTAATYKGDGDWFKVYSLTTSNLTNDPIFWAPFPGSVGIMDFTFTLPTSLPNGQYLMRAEGLALHGASTVGGAQFYIGCAQLDVTGGASSGTPGPTIKFPGGYSTNDPGILVNMYWPPLRSYTTPGPSTWPNKCEDHSPNLFGETSDGDCTPLAKGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS98</accession>
    <name>A0A9P4PS98_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalamin synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_452270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS98"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="7">
        <location>
            <begin position="316"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="544" mass="61161" checksum="5F3760095870325B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSR3</accession>
    <name>A0A9P4PSR3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_143689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSR3"/>
    <dbReference type="OrthoDB" id="5377213at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47118" checksum="25AD8767C4073A31" modified="2023-09-13" version="1">MSSSRPPIGVRGPSQHGRLHRRGHSASSMTSPLSPGQFAFSRSETPVTYEEPWTDIAQPMPAATSHAHKIKPYLRKLSSKDHNDLDLSRPAAENERLAGLGIVEYGRYTRTVGDVNFASVKSRNHARSTSNTSQFSTSSSLQRPMPSIRQSPLPYTPPISKSTPAATLLNAAHEPEDNIMTDDEFRRRQAAYDPARKSGSLSSSTPGQTAPALRIHTTGSSSFLAGSYSPSTVSLTSPIAQSRSRGDTVKSMDTTSPSSRTSFDKAFGFIRPGRDSPVDAQSRAASIRAARQAFEEKEAAKERKYDREVHKKVERETKKQYKKDENERRKSDSNDKKRSRSVSDSNSYERTSRPSVGARQYSDHREAHTSTLPNLVPSADPEKSGYAPTPKVTKSRQAKGRWLRFLIWFKTRFLRMGTKLHVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTG0</accession>
    <name>A0A9P4PTG0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_481148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTG0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="204" mass="22844" checksum="28211D2B7D926006" modified="2023-09-13" version="1">MAQWVQSLSEEELSSTTPAIHLPSSYLDPETNEYWDFSSSGSENFSDGEQGMAGNEDVSPLDLKPSCHRGPCVLNDLSLPLEPDPNLLPEHPHLPPNQMRRVPIVTFVTLSVRPSSSERSHQTRCKRDPDVSLRDEEWGFVNGTIEKRRADHQDTSLPHSTLDGGPGNDIPSDGHGHGHRHDHDQSLNRYSTLELLRLKRGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU27</accession>
    <name>A0A9P4PU27_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fermentation associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_516201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="139"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="596"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="4">
        <location>
            <begin position="2495"/>
            <end position="3128"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="4">
        <location>
            <begin position="3194"/>
            <end position="3262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2461"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2551"/>
            <end position="2572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="2970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="3190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2463"/>
            <end position="2484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3139"/>
            <end position="3170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2450285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3263" mass="363251" checksum="E5F66625D579446D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU89</accession>
    <name>A0A9P4PU89_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_460670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="ABCG_PDR_2"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="PDR_CDR_ABC"/>
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    </dbReference>
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        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="705"/>
            <end position="723"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="844"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1265"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1379"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1414"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1532"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="229"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="930"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2449373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1582" mass="176688" checksum="32BFEC5D62464A71" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU95</accession>
    <name>A0A9P4PU95_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_509469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PU95"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF2">
        <property type="entry name" value="ALPHA_BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="149"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2449054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="391" mass="44479" checksum="9E92B528EE7003F4" modified="2023-09-13" version="1">MILSQISYLDCIVFLIFLVPQLLIQVGLIRTATWVLGALPSLTLQVFVLPFQFIRERYFTPYEHRSAFVQRATPFQDFVIRCVRYAFAFMPASLGRVFFSKGVSLPFLRFRMLRHGIVTSPLRWNEINRPDLKGIWITHNKQEQPDIIVYYCHGGGFAMGSGFFYMEFLLAWVNLLKEAGYRNPALFALEYTLVPDAVYPTQLQETLAGYEYVLSIARNHTRICVGGDSAGATLMLSFLLYMTDHPELRHQRPGLAVMISPWVTIISKNNRNTQSDFLNATSLELYGRQYIGPKVPSDDPLVSPGNCKDIKKWTAASPEKGWFFLYGSEEVLGPETRALISLLKKAGTNVDHYEQPGGIHAWPVASLYLGETRDARLHGLRDIVQTIRSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUA7</accession>
    <name>A0A9P4PUA7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_482104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUA7"/>
    <dbReference type="OrthoDB" id="5361354at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="379" mass="41134" checksum="BCED5E61E7FB5523" modified="2023-09-13" version="1">MGNWFGNLDLAYKYTVVFVALLLLAILAGLVKVFFGRRKLKKLTTKQNEHVQVKEERMELTGREKDEGDYFRVRALEAGFYAGVAQSAPTSRAGSVAGSPFMSRSTLVGGSVGNLKDPMNNSVTTLPLAHTKKRNNSNSGDSDSLPWPQSEDPPRRKSPPAIRLAPSTAELTGRHRFSATADMNLDVPLSPSASRGPSFPTFGGSDNDDSDGALSPRSQLSPTSTMGHYAPDPPPLPMPQPDGFRASFVSVYDRYKSQTASMLMASPITSAHPSMAMPGITLNDGDAPPRSPVRLLPRTYQPSHNRDDSDSSSIYSEGRHSMPEKDGKHKWTIAPLPAEKEKRSTLLPPAGGDNRYSDMYEAYYRHSTINGGQSATGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVG1</accession>
    <name>A0A9P4PVG1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVG1"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34823" checksum="8ADCC0C1581C6938" modified="2023-09-13" version="1">MQVLRTFQCIVKRIIHTLTTLLVHIATLPYYRLYQFNTRSPMRNIAKLASETPPDDAKLLRALLSWRSRKISELQFTTVSCTVLAAAVIGAFSWTTVEEAHWLTHGMWHSSLILAVLGILLSASEVTVLYILGPTEMTVKPYRSKPILQRYHPLLLSRSNDSTQAFVLRRKMMFTWQGPLMFMSYSVCTFLGGLTVLVCTPLIRYKKGDRWISGHNVAVVYLVVLVLAGALFVFCSFWIYHYVSAGLDGGDYFAGNSLWDEEDGNEMSLGKLSFRNVLAPFGEEGPATTTAIHYRQRAPQDDGSRAGQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVM8</accession>
    <name>A0A9P4PVM8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_427342</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVM8"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2451125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="311" mass="35212" checksum="4CA84369DD07D58A" modified="2023-09-13" version="1">MSLTNSRFYEEKYPEVESFVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVGRNEVVVVLRVDKDKGYIDLSKRRVSPEDIIKCEERYNKSKMVHSIMRHVAEKTNTPIQELYENIGWPLNKKYGHSIDAFKLSITNPDVWKDVTFPNDVVKEELQTYIGKRLTPQPTKVRSDIEVTCFGYEGIDAVKEALRTAEAKNTQETQVKVKLVSPPLYVLTSQCLDKSIGIQVLEQAIEDIKASITKAGGDCSVKMAPKAVTENDDAELAALMEKRERENQEVSGDEDESTSDEGGVAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW19</accession>
    <name>A0A9P4PW19_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_438959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW19"/>
    <dbReference type="OrthoDB" id="5430580at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="411" mass="45252" checksum="E8C63262EC2282FD" modified="2023-09-13" version="1">MPQNSPSQRGRNEESRDYTPLATARQLPASQIPSSRHAALGTSRQLPAASASSSRATPVGTARQLPAAESSGASRQLPFRTSRQLPAAESSETSLQLPFRTSRQLPAAESSKSVEHSPLKTSRQLPAVESSHVQSSSRGAESSPKESYWKKSTHHHEHDDYSRHESSRKESTRKDHYYNESSQKDSSHKDFSHKESSHRDSSHKESSHKDSSHKESSHKESSHKDSSHKDSSVKHTSRKEPPRAPEPSRNTGASRITHPSNKKASSKAPTPATPTAGASRITKLVPSSSSKKRPDYEKTMPTGAVRNTSAGGVSATKSNYPEYATRGLTEHQLKVHDVLMIKVPCPQGYIWLKQDVGWRCEGGTHWMWDKQADRIARGEDPAIVDCQRGAGPPGSDTNWGMRGGPRNFRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW70</accession>
    <name>A0A9P4PW70_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_516334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW70"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="80"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="430" mass="47057" checksum="2D74E67F6DE5AC6E" modified="2023-09-13" version="1">MIPLVLTPSCRPHSRNAKYQGLLSKHASPNDVTIMQVLYHICPSQSRYSPLCNITLHASLPKSKSSEPRTITNPTMLPTSSAQLTCLCGQISLPGTSLSHPTFPLPSTICHCNPCRYTSGGLLPAFACLDSAPPLEIKEKLAKYQFTPSCVRYFCKKCGCQCFVEHPQAEEEWFCTAGMIEIDGKEEGRAEGAKEVVQLTGHMYIDDLRDGGVVPVFLPITATGASEPELYCARDGTSKLSQQDLDNAVQTSHQHPTPGPEDRLEARCHCGGVDLRIKRAEYDAEPEGVRNLMSRDDPHRYLARFCACRSCRLSMGFSLCPWTYVALSSVINAKTSQPVLFGADAEKEGANEGLKLQHHQSSDGVWRSFCGGCGASVFYYTSDESRSNVVDVAVGILRAKSGSLAREWVRWAEGEGKEMPNRSNAGSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWH6</accession>
    <name>A0A9P4PWH6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_426010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWH6"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2451502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="438" mass="48442" checksum="84677EC6CE19D46B" modified="2023-09-13" version="1">MAEERYREYLADRVLAEGQPITYRLLSRALKVHVNIAKQMLYEFHVEQTTKQPKSVHATYLLTGRERSSEHSNDDNAHNGDDTAMRSSPFMSSLPEPENTPESPVPTTSIVLVREEELEKTKSEFEDITSIHVYSLEPGPIENMNLLAVCNQEIASNYASGDPLERWRVYGSIQNPYIKRRTTKYAPVVAKPATKATVKSTAAVSAAKEGTKQAPAVAAHKESTPEESKSGRSTPQPGPAASLKRLDSKTKAKKDTSVGNLFKSFAKAKPKAKEAEKPKDEDEAMQGMSEDEGDADDEPAVKFDEQKAAAARKAREEREQKLQEMMEADVDMPDAPTGEKTSQDAPIDKETPSQPVETEETVTVQGGRRRGRRRVMKKKKVQDEDGYLVTKEEAVWESFSEDEPEPKKAKPTPKSTAAKGKKTGGKGQGSIASFFKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWI7</accession>
    <name>A0A9P4PWI7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWI7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="55" mass="6241" checksum="57E77F34F270040D" modified="2023-09-13" version="1">MPTVATPSPPRRNHARDLHMSRGNPQKQRLAKHLPHAAIVEVLKDPRRTGYPRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX32</accession>
    <name>A0A9P4PX32_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX32"/>
    <dbReference type="OrthoDB" id="3705926at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="491" mass="56027" checksum="7C8691957223FA36" modified="2023-09-13" version="1">MASFLSCPTELADSILKQVSFRDLATVSLVNKKLHKFATPHLYSQVNFNIYRDNPRPIIHLARTIFNKPELAKLVKSVCLRDGEESIQSMWEPGDWYGQYKVPLASPPHPATDDGLPEFVSFVAESGLSYADIWIDNLQVGDLNAFVALLISKLPNLARFRVGYAVVLPFLGTRTSAITKPKIVYNDAFLGKLFQSAVFDTSNHGLSRFEYLEEIFFPGPLESDPGPNPDFCNQGLFAFLNLPSMRSISGWCFNPKTLPFTWPSGLPDLTNLTSLSLKYVHIDFLAQVLERTRNLKTLSWEWFYIPDYGDQFNTDTLDLDKFVEALMPVQETLEDLTIKFTNCMGTWDPDVQRINVLGSLNGLQQFTGIKRFWAPFQLLLPDWESGANWARRLEDSLPRNVEVVTVTDSVASTEGYPYDEPDEFAFLGRWLHETAATRTPHLSEVIVYMSDWSGFLKFYESFDMVHQAFEGTNVKYRIIDEDKEVRLWEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXC0</accession>
    <name>A0A9P4PXC0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_21294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXC0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2452206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="153" mass="18189" checksum="82E2E54ED5F0D01F" modified="2023-09-13" version="1">MRSPPHCMEAFSYSSPSDPSPVHIRAECYADSVYLTCRQTAYFQPFIITWRHWLCLRLHFYKITRTRYCNCRHLTTIPMVAMRRVKYARHHRTSMNQSLDYPRDHFGHVSRSSLLSLNPNRIGMTTRLNCVFALGSKQQEKLSKMYLNQKHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXC2</accession>
    <name>A0A9P4PXC2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">URM1</name>
        <name evidence="7" type="ORF">P171DRAFT_15858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXC2"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2451977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="110" mass="12345" checksum="7DA259E1DEF6B68D" modified="2023-09-13" version="1">MSDAKDEGMIKITVEFSGGLEMLFSNERKLSLTIPAKDEDGTRSNIAFLVRHLCDTVMKDPRKELFVLDDTVRPGILVLINDADWELEGEDKYEIEDGDNILFVSTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZQ9</accession>
    <name>A0A9P4PZQ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_14285</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZQ9"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="210"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2451874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="384" mass="40580" checksum="1E776B7FBC5BED2F" modified="2023-09-13" version="1">MPADTVGKTITCKAAVAWEAGKDLSIEDIEVAPPRANEVRIEIYYTGVCHTDAYTLSGKDPEGAFPIVLGHEGAGIVESVGEGVTNVKPGDHVVALYTPECKECKFCKSGKTNLCGKIRATQGKGVMPDGTSRFKCKGKDLLHFMGTSTFSQYTVVADISVVAITEKAPMDRTCLLGCGITTGYGAAVITAGKGGLEKGSNVAVFGAGCVGLSVIQGAVKNGAGKIIVVDVNDSKEEWSKKFGATDFVNPTKLSGQSIQEKLIEMTDGGCDYTFDCTGNVNVMRAALEACHKGWGESIVIGVAAAGQEISTRPFQLVTGRVWKGCAFGGVKGRTQLPGLVSDYLNGDLKVDEFITHRQPLDKINQAFGDMKAGDCIRCVVNMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5G3</accession>
    <name>A0A9P4U5G3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_177343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5G3"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="73"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="331" mass="35193" checksum="4A4179880D7C9B92" modified="2023-09-13" version="1">MSLSPTDVVLPRPGQKSVEVKPPIPGPTESAFTDTFGSLLPPAKYLQTENGKAAYYEILPSTPATSLTTLDRVLLIHGVQTPALGLLPLVRALQKAFPQTHFVLFDHWGHGLSDTPFLPHEPSLFHGLIDALLDQLNWPTVHIIGYSFGGTLTPAYVVSHSTKVKSFTLVAPAGLMRLSYLSAEEQGHMRGGGDEDAARKWVHSWLEGGGELIVPGNWEESVSKGEIVAPAIKRWQLQKHAGHSASVVGILRDGGVFDNHDAFAEVARTGIPSLAVLGELDGIVDAQTLGDVGITNVEVVSGAGHGVVRGNVPEVAAAITAFWNKIGPNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U609</accession>
    <name>A0A9P4U609_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_437071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U609"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="42"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="142"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="254"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="528"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="784"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="818" mass="89881" checksum="2ADE96F884FC2D24" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U612</accession>
    <name>A0A9P4U612_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="4">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_437339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="4"/>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U612"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="11">
        <location>
            <begin position="8"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2438291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="367" mass="39678" checksum="9B9111C03BCF553B" modified="2023-09-13" version="1">MATPQKLKIAVIPGDGIGKEVMPLGVRCLKAAASTFGLSLEFTEFDFASCDYYAIHGDMLPEDWHSTLSAYDAIYFGAVGMPDIVPDHVSLWGSLLKFRREFDQYINLRPCRLLPGIPSPLANPGDIDFWVVRENTEGEYSSIGGRIFEGTEREVVVQETVMTRIGVDRVLKYALKLARSRPKKHLTSATKSNGISITMPYWDERLKALTKEGGYDDLSIDKFHIDILTAWMVLKPSQFDVIVGSNLFGDILSDLGPACTGTIGVAPSGNINPEGTFPSLFEPVHGSAPDICGKGIANPVGMIWAGQMMLQHFGYGDAAEGMMRAIEDVLKEGGEHVITPDMGGSTGTTESLGAAIEKKILGGVGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7N9</accession>
    <name>A0A9P4U7N9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras guanine-nucleotide exchange protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_72289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7N9"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="82"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="770"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="952"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1202"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="707"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1204"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1245" mass="135775" checksum="16AF88221523AEFF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U856</accession>
    <name>A0A9P4U856_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_369149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U856"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040177571" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="34"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="335" mass="37162" checksum="0A65A7151A62EB45" modified="2023-09-13" version="1">MRWTTSTLVALALASPISALIRFQCSQLVVERLDPLVTPGQVPSPHVHQIVGGNSFNATMAPSKDMPGESTCTTCQFSDDFSNYWTAILYFRARNGTYKRVPQRSNAGFDGTTGGGMTVYYMTDPLYDSQPKSKVSAFKPGFRMFVGDINARTKEQAVRFRQLTYTCMENAGSREHEVVHFPQKPCSYGIMTSVRFPTCWDGVNLDSPDHMAHMSYPESGTFESAGPCPSTHPVRVSQVMFEVIWDTSKFSDPADWPEDGSQPFVWSFGDPTGYANHADYVFGWKDDSLQNILDTSCYATSCGGKQQSIAAMNKCAGLKKTVDENIGEDTCEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8C6</accession>
    <name>A0A9P4U8C6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translocation protein-like protein sec66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_464928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8C6"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2442159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="243" mass="27418" checksum="F4A3A20AFD0F8797" modified="2023-09-13" version="1">MWPFDAVDWVMLSIPIAYLFILVGSLYTFSSIYRKRKAYRAASLEPWFSQHLQRDVYLSLLHQENPKVPDSILKAALLRRATEDISRIIQVRSQKQALQVLLQRGSVGDDLWQRFQRAEKEIEDELRDVVQEANAFAPNWGQSIFQSASELSQNNLLRERLNEILATADSERQWWDKRRSEIQAELLGELDADKTKSPTEGSVAGSIAGSVRGTKTASDDDAVLVESGGPAEKTGKGKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8S6</accession>
    <name>A0A9P4U8S6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8S6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="318" mass="35782" checksum="D5A9D0E6FFE4F268" modified="2023-09-13" version="1">MEPSRKRGRDANDRSSYYARRRQDMLDVRKCVKELQTADDGTIYKIIERWADADDTVAMDLHKAYGTLQARQQEHGINFDHHIKAVLYKLHKDDLWPQRPKHEAAAEVPAFIEKTIETIGRKATRHSSYETKLAGLRTLLQIGKIICGCVNEGVEQAVRQHFQKEATLGDAMYNIAESMGQSQLGGLCSEVNGEPTFLENMEGLVALEEETQMEMGLAEVLNLFTDTEDATEGEDESEDGDGEDAGEGDNEDRDEDENGDGQDEDEEEDDSDSEGFDSDGVVKAPRREVRNRRSRRTVVPSNSSKGKYTSLPWLGNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U981</accession>
    <name>A0A9P4U981_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_395508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U981"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2440782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="222" mass="24326" checksum="3FAFEB31076A97ED" modified="2023-09-13" version="1" fragment="single">MSQYAKLKNDELQAMLRERGLPTTGKKADMVDRLTKDDEKTSEPAPSNAHPEDEIDWDDGDEAANQEEKADKKTASEEPAVTTQSETVAKAGGTGQPPNPQAVPNQKIDIDPSKTDDLSVKPAGEETDGAVEAKEEENKEPAPSYAAGVAATDLDAEIEKRKKRAAKFGLKVEDDETLKKLERAKKFGESGALKGLDEALPERKERKRGREDNEDAGRNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9C7</accession>
    <name>A0A9P4U9C7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_418693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9C7"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="718"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="990" mass="110122" checksum="2B630E48024B64F8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9J8</accession>
    <name>A0A9P4U9J8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_90396</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9J8"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="85"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
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        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2441142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="583" mass="62453" checksum="C3E11FF491C657DF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAC2</accession>
    <name>A0A9P4UAC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_486865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="141" mass="16143" checksum="4FC2482CEC1CC2FA" modified="2023-09-13" version="1">MSSPSRSACFDRSDRPAVATRMLVPGDTRPISKVKRLQKARFSRVSADQDDKVTRPTVWAQKTSSLVEEVKIDLLTHDIDYWNWDLPETWWEGIRDWLDRPISPLARGQVKKMDRRLIVVYHGHVRDSGNIATSTRVDAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4UAG6_9PLEO</name>
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            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
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            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
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        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">P171DRAFT_416375</name>
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    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000328">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="201"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2443031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="282" mass="31104" checksum="449543EDB1FF804B" modified="2023-09-13" version="1">MSPVAGRTDWAEEEDEDSLVLPQQQIIKNKDGTETIITYAVRDDGKKIKTTRRIKKTVNKIVVNPRVAERKHWEKFGQEKGKAAGPQTDTVSVAENIVFRPVAGWKANTEEKSQEEKSKADALKSAKIKCRICQGDHFTTKCPFKDTMGEGEVAPADMPDDAPQAGGTGMGSGSYVPPHLRGRGAGAGEKMGGKFERDDLATLRVTNVSEFAEEQDLRDMFSRYGHVTRVFLAKDRETGRAKGFAFVSYADRTDAAKACEKMDGFGYGHLILRVEFAKKPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAT9</accession>
    <name>A0A9P4UAT9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2443406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAT9"/>
    <dbReference type="OrthoDB" id="3691606at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="570"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="918"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="530"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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        <location>
            <begin position="1067"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1129" mass="124334" checksum="67E0F47647FE7433" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBL7</accession>
    <name>A0A9P4UBL7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">P171DRAFT_513069</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
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        <subcellularLocation>
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            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="181"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF2445729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="257" mass="28156" checksum="85D131AE5D6EF898" modified="2023-09-13" version="1">MSLLDAHLEQISLCARSIAELPFPPPKIFTNALLQSHDITSLIRDTESHERALFSVPPAATAPKAQESAGSSNRRNTIFNANGPTAGIAGGGANAMRAPKRNTAVAAVLGTELVERIRRGGGGGAGSGLGYRAYDGVNKNDIDVETLLEGAEKLLGVYTIPGAHDRIASMRQRHGRLEASIEYYESRIAEQTAQLSKLNRSREYIDREPEVVENVAPVMTEEDLRREEEEVRQLERRKRGLEDHVNSMGRDISGFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCN3</accession>
    <name>A0A9P4UCN3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10430096at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040197226" evidence="1">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="72" mass="7599" checksum="F5C1C73E96B116DF" modified="2023-09-13" version="1">MTPLLFLALVFSTATVSAIPTFAQNPNTTFHGGHERACDRRCAQSDVGLECAPGFAGRNGVCGILSSLFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD72</accession>
    <name>A0A9P4UD72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_429146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD72"/>
    <dbReference type="OrthoDB" id="5397557at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="403" mass="46569" checksum="8D01E6BFA0FD7DD0" modified="2023-09-13" version="1">MVRAVAYGNWKQLIDAGIFGIECTWQGELRIPFACHIRQPNSTAPSNVSFHQFARLPAELQLRVLRLCGKPTLFQLMQTSHLIRTEATKLFFSDPEAWYCVEGEWLEMGGHPSDGLHDIDFLHCIQRLHVDFAMMIEETLTDGNIRKFWRRVQCLFPQAKYVLVGGGTEDGLYHPVGSGTATSPPPTVCRRVCQLCPRDINVFVSILRRGDRVKRTLWRRVTTQEDSNETQELVECEDHPGPGIIVPHKPFRGQVGTCQYLWSQGSAIARQNLALLVLRTAAIERYHLHGRHEAFVCRARGCDAWFERPEEFTIHVVGTGEQHDRYVLPEPYQSLFADGEKRLEQVKQRHREIKEQFLKWWGEFGSEERKVAQEEFLRELEHDSLHVQGESPSKRRWLSIMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDB3</accession>
    <name>A0A9P4UDB3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_384851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="3"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDB3"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04901">
        <property type="entry name" value="ACT_3PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="412"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2446151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="482" mass="52351" checksum="E91E64AE0AD1F27E" modified="2023-09-13" version="1">MSPSSPPRQIPVPTSNMSNLSRQVSNSVNLSTSPNLSFHSPPTSFRPPPSYTGSNGAAAANAKQLKPFDTKDVKVLLLENVNLAGVSILQEQGYQVEAIKSSLPEDQLIEKIRDVHVIGIRSKTKLTERVLKEAKNLIVIGCFCIGTNQVDLNYAASQGIAVFNSPFSNSRSVAELVISEVIALARQLADRSMELHNGTWNKVSKGCWEIRGKTLGIVGYGHIGSQLSVLAEAMGMEVIYYDVVNLMGLGTAKQVKSLDDLLDQSDFVTLHVPETGDTKNLIGKAQLDKMKNGSYLINNARGKVVDIPALIEAMRSGKLAGAAIDVFPNEPAGNGDYFNNELNDWTKDLQGLKNLILTPHIGGSTEEAQSAIGAEVSTALVKYVNEGTTLGAVNMPEVNLRTINLDEPNCVRVVFIHKNVPGVLRQVNGVLLNHNIDKQSSDSRGDVAYLMADVSDVKEDEIRNLFQSLEELPSSLRTRMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEB3</accession>
    <name>A0A9P4UEB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Glycosyltransferase family 57 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_461453</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
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            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
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            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
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            <end position="243"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
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        <location>
            <begin position="487"/>
            <end position="614"/>
        </location>
    </feature>
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            <begin position="945"/>
            <end position="1008"/>
        </location>
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        </location>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2448714.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1545" mass="176629" checksum="3C85E1AF422561CB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEK9</accession>
    <name>A0A9P4UEK9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfate transporter family protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_227320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
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            <end position="435"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        <location>
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        <location>
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        <location>
            <begin position="675"/>
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    </feature>
    <feature type="domain" description="STAS" evidence="8">
        <location>
            <begin position="745"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        <location>
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    </feature>
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        <location>
            <begin position="875"/>
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        </location>
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        <location>
            <begin position="55"/>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="180"/>
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        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="892"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2447561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1105" mass="121572" checksum="3861F8DF3D3BCFC5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEW0</accession>
    <name>A0A9P4UEW0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_460651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEW0"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="11">
        <location>
            <begin position="63"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="495"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="801"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="806"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="181"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2449344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="853" mass="95002" checksum="17936018EF4EC0BC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFC1</accession>
    <name>A0A9P4UFC1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_337432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFC1"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8959" checksum="A6A750179027814A" modified="2023-09-13" version="1" fragment="single">KKQWIACFVAYAGPLSALISFIYPQALYNITQDLHIDSTMANISVTAYMVISEFPRSLLGNMADRLDKRQLYIGTCAILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFD0</accession>
    <name>A0A9P4UFD0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_236047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFD0"/>
    <dbReference type="OrthoDB" id="3783802at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="233" mass="25791" checksum="240E982EBF7EBDD6" modified="2023-09-13" version="1">MAPLPADDQKQTIDQPSTNEGGKSWTTATIAIGAVFLFLFLALIATIIVFCLHKRKLRKKLPAEHRPRPYHPFRTGSTDKSSLLADAQTPEEERSSMFSHERSSVSVYVDVEPTNRRVSSQSMETVSLIPLHVAPPERHESLTGEISNRSGVSASSSRYTRQSISLSPIQQEDGDLGTRPNRPRSTSTSSVRYYGKKEGRPDSTTWKTSNSPHTSLAAQPLPEIPRIVHTLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFV7</accession>
    <name>A0A9P4UFV7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_452602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFV7"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="217"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2448941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="321" mass="34621" checksum="14F5C659BF10C88F" modified="2023-09-13" version="1">MSAKSVNGPGGKKPASAATNLIAGGGAGMMEALACHPLDTIKVRMQLSRRARAPGAPKRGFLKTGQEIVKRETPLGLYKGLGAVLTGIVPKMAIRFTSYEWYKQLLADKDGMVSGRATFLAGLSAGVTEAVAVVTPMEVIKIRLQAQHHSMADPLDIPKYRNAAHALYTVVKEEGFGALYRGVSLTALRQGSNQAVNFTAYSEFRAALQKYHGTTDLPGYETMLIGLVSGAMGPLSNAPIDTIKTRLQKTPAEPGQTALGRIMAISRDMWKQEGSRSFYKGITPRVMRVAPGQAVTFTVYEYLKGVLERGREMLPGGQYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGI5</accession>
    <name>A0A9P4UGI5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGI5"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9793" checksum="4E9D6D8F70BF8F78" modified="2023-09-13" version="1">MKSNNDGAQPPDQRRRPHQGRPENINNTPEDISHAASGHKANLSNPTMFSLLAGSMRCMKGIQASKEKSKEALKELGGEEAFYGKQGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGU5</accession>
    <name>A0A9P4UGU5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P171DRAFT_492837</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGU5"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25880">
        <property type="entry name" value="WHD_CHMP7_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2451474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="612" mass="68099" checksum="0FA90CA61606A9AC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH30</accession>
    <name>A0A9P4UH30_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_427913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH30"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2449750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="202" mass="23138" checksum="8B1AB039B2AA1962" modified="2023-09-13" version="1">MSSFDPVIVIDGKGHLLGRLASTVAKQLLNGQKVVVVRCEALNISGEFFRAKLKYSAFLRKQTRYNPTRGGPFHFRAPSKMFWRTVRGMIPHKTPRGNAAMERLKTFEGVPPPYDKKKRVVVPQALRVLRLKPGRKYCTVGRLGHEFGWKYQDVVSRLEERRKANGAAYYEKKKQARRQLGQAKKDAKVDTKVTEQLAQYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHY4</accession>
    <name>A0A9P4UHY4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_379896</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHY4"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000016">
        <property type="entry name" value="Membrane bound cation transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="146"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="600"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2449737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="782" mass="82913" checksum="0034203662356C06" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ85</accession>
    <name>A0A9P4UJ85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_480112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ85"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="128"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2451072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="434" mass="48271" checksum="653C8EAA2D7F7F28" modified="2023-09-13" version="1">MASRQEAEQQLQKMTSGLIEKLTPVLFAPVSMQKMVTSRDTPAKGPVWVSRTVFDKPEDSHELRSMLEDAFKPLDLGGDSTYDFSIEDVDVQWTAYRSAGKGKEPEPEISEQDKFDGLMKDISTDTVILYAHGGFYYTGGPASVRATTLALARETGGRCLVPAYRLAPQFPFPAAVVDLFLVYLSLLRPGKGALHTPVSAQNIVFAGDSSGGNLVLSLFALLHHIRDHAGGRVRFRGHQLDVPLPAGIATLYPHCDHTSSFDSHTSNKPYDIFILDALLHLQPTFPSCDTWPTKPPREDIYCDARTLIHPLVSVAIAPAWSAKDMPPMFIATGQEKLTDEQYYLARRVERAWCNGAVLPHVVRSWGRFCREVVARPGVLENAWVRYAADDVEFRGMELQSPVDVDEDVDVRREKMKEKVAGRKVWTGPTETAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4M9</accession>
    <name>A0A9P4P4M9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_459306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4M9"/>
    <dbReference type="OrthoDB" id="3912456at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="249" mass="26936" checksum="11A391B190553F63" modified="2023-09-13" version="1">MCYANFTQHSGCGHIGGSSTRPLTLCDDAIQRLYSLRGPNSPPISSPTQQNTFFPPPRRSASKRRFFSLSQTLSRTSSIASRSSRSSAGTGVDGRPAPRSAAASFSPSTTVAADIDYASLPVHQLNAVKCREPIRRSQVASDMDVCPECKKALVDMRSMLERYDKSGSIRGTTAFEQFLRFGDDRNYTADGDVTIPVRDSVAGEHGAMQAIVLGHASESPNLRERGGTWGDVDAETLSDHHVNHISFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5D3</accession>
    <name>A0A9P4P5D3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_179880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5D3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="134" mass="15309" checksum="0E8C7088AD9A493E" modified="2023-09-13" version="1">MDVFEWNTGWFLRHWPTYCPCRRSCTHAYGPSDAQHHHQIVPHSLPTTNEASAVHTPNPPFRRFHALAAFPQMMLSLQQGWAGLTSLPHQVPRTRYNTVTRASRSAQKQHTAPSLTTQASTLCRGLRLQRPFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5U5</accession>
    <name>A0A9P4P5U5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_437892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001517">
        <property type="protein sequence ID" value="KAF2437298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5U5"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
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        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
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        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IBN_N"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1045"/>
            <end position="1073"/>
        </location>
    </feature>
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        <location>
            <begin position="1045"/>
            <end position="1055"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2437298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1073" mass="122819" checksum="CE66FDEE3FB07C11" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7C5</accession>
    <name>A0A9P4P7C5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_155705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="101" mass="11102" checksum="515A0D1B63A95FC8" modified="2023-09-13" version="1">MPKQSTCACTIGVPRLVGLLRGARADDHGLQSCLPGVLVSRMSWRACGVVEACVSRRETYTSRKSVHTCCVLFASCSCFCRPNHEVKSSEPRNTRMRTPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7S1</accession>
    <name>A0A9P4P7S1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_477644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7S1"/>
    <dbReference type="OrthoDB" id="10674158at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="610" mass="69708" checksum="CE5F1A7D64F68E2C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P897</accession>
    <name>A0A9P4P897_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_504156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P897"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051670">
        <property type="term" value="F:inulinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.560:FF:000003">
        <property type="entry name" value="Extracellular exo-inulinase inuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF1">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="61"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="151"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="299" mass="32506" checksum="97396CC044C07A99" modified="2023-09-13" version="1">MILAHGGQDKMTFWTSPDAKEWTWQSEFTSNDTGLPHDTTGWEVPDFFSARCRGFHREEMGHFTADSASLDTLWLDYGRDFDDALSWENVPTSDGRRIIASVMNSYGDKPSTTTWKGMLSFPRTLKLKSVGGKLHFLQQPVQELDEISTTIIKITNQTLAPGQTLLSDIHGRALDVRVSFIPSAGSTLSLSVRKGEPEQTVISYTQSDGTLSVGRRASGDISWVPAAGSVHSAVFTADTNGVVRLRVLVDICSVEVFGGEGQVVISDLIFPADSSDGFSLATSGGTTELAEVQVLQVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8F7</accession>
    <name>A0A9P4P8F7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aromatic prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_501454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8F7"/>
    <dbReference type="OrthoDB" id="3354387at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF4">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="447" mass="50511" checksum="137E0EBFBBF2E514" modified="2023-09-13" version="1">MAPSAVSVESSIEHAVNYLTKTSNGSISTLKRKVLTSQVISRTGRTDTKQPFDIISSTIHFRKPEHQFWWDKTGSQLAELLKYAGYSKAEQYNELLFYAIQIVPELDPTPDANGHLRWKSPQAPDGTPLDLSWEWGLEGKGVVRTFFEPIGPMAGTEADPFNRNETNAWIKHLDSQGWVSGLDLEWYNHFTATVLPSELGRVKMPKKLHFELAPVAGTFVTRDIDRNGPIIKLYIFPGLRAQELGVSNLDVVVRAIRSLPAEQYASLRCEPMLEYLHEVAAKWKMDVGIFSFDLVSPQQSRIKIYTRAPNTSVEYLMDALMLGGRYDMAMYTAEAIADVKDLWHIFIGDAPAELPSEVERAGPGFYFTVKAGKPTTPMVYISPASFCKNDAKVLRRLRRPFATRKNADKMLPQMENYVEMLRKIYGEEFLESTGDIYFYVSCALAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8X4</accession>
    <name>A0A9P4P8X4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial genome maintenance protein Mgr2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_524607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8X4"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12365" checksum="CB3B55B37D2B986B" modified="2023-09-13" version="1">MPVPVGAMPGGQHGPSTLDKLKMGGMMGGSVGLIIGFIFGFTNIVRFGPGPNGMLRTLGQYMVGSAATFGFFMAIGTTIRTDSSPIAAEAFAKINRRPMILPRQYQYPQASHEEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P968</accession>
    <name>A0A9P4P968_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HlyIII-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_157547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P968"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="317" mass="35442" checksum="98AB79894C3D8B1F" modified="2023-09-13" version="1">MASLAIALRLPLLLFRKPSKGRKHTTSKSPDADDTPQRLLTYNELPDWYRLESSPFITSHYRPPSHSVTKSLHSLGHLHNETANIYTHLIPAIVLAFSLPLLQLNISAAYADAPWLDRFMLTLTPIAALFTFSASANFHTLNNHSSTVSLSCLLLDFTGILALILASLLSGIYVGFYNHPFQQRLYWSIITGLVATSALLVLHPALQGMHYRPHRTAAFVCTTLSGLGPTVHGMYVHGVARGWHECGVKWWVAEGAWYALGVVFFVSRWPERWAWRGEKTRGRFDVWGGSHGVFHCCVVVGAACHCWGVWEAWRNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9G7</accession>
    <name>A0A9P4P9G7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_111512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9G7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="173" mass="18921" checksum="1B887AC5C3DF925C" modified="2023-09-13" version="1">MLCGQLKTIDGSVVRHSGATSLAFARHVPGYGLLEGRFGRQAGGRFGRRAAMLRSCRLAGCSTAGRLQRAIQAALSAEVRECWRAGVCEVGVHWQLGGTRWWSRLQAPFWRGKSNPAANQTVLSTTVRGSAHQHRMHASGQGINNGRQPWKRNESRTRDGRGTSTTPPARPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9I9</accession>
    <name>A0A9P4P9I9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9I9"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01709">
        <property type="entry name" value="RT_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="958" mass="109946" checksum="12E30F5E631AC423" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA38</accession>
    <name>A0A9P4PA38_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_501213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA38"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="352" mass="39774" checksum="454F274D46DEF1BC" modified="2023-09-13" version="1" fragment="single">MVRVVNTAKENIKSPYLTLSHSWGPPNFLQLKKENEGRLMGEGATITELTPNFQQAISVAKFIGIRYIWIDSLCIMQGPGGDFKSEGQLMHKVYRHSHCNIAIADSLDSEGGLFRQRNPANIVPMSIEADGTGKLPRGNWRILEDDLWDEELLATKIYTRGWVFQERMLSPRILHFAASQIFWDCSTLSACEAFPRGLPHALDAKASIDRHWRGRMQRMLSDTPQGYGEPVVGANDDSIENFWLSALLSYTSCNLTNQDDKSVAIWSVAKLVRDILGEQYGGGLWENNLEEQLAWHSYNMTSEGCSRIPELQSRYPSWSWASIKAPIIAHSRLSKARQYVVTNHAGDAIRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAF2</accession>
    <name>A0A9P4PAF2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_419735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAF2"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="349" mass="36627" checksum="E350341D208B2B2C" modified="2023-09-13" version="1">MSPPTLQTSLSKLLGIQYPIILAGMARTSGGPLAAAVSNAGGLGVIGGLGYTPAQLQSIIDELKSNLSDKSLPFGVDLALPQVGGSARKTNHDYTHGQLDELIEVTIKNGAKLFVSAVGVPPARTIKRLHEAGIVIMNMVGHPRHAVKALEAGVDIVCAQGGEGGGHTGDVANSILIPAVVDVARKYTSPLTGQPAMVVAAGGIYNGRSLASSLMQGAQGVWVGTRFVASTEAGCSQQHKENVVSARFEDTDRTLVVSGRPLRVKLNDYIKGWHARPEEIKALTEAGVVPLAKDMEDEKEFDIPFLMGQVAGEIRDIKPAKEIVGDMVSEAVEMLRLGQTFIAGPSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBC2</accession>
    <name>A0A9P4PBC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_435881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBC2"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000006">
        <property type="entry name" value="Autophagic serine protease Alp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="42"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="175"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="538" mass="57945" checksum="E2FB510D6C71243D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC11</accession>
    <name>A0A9P4PC11_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arad-like aldolase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC11"/>
    <dbReference type="OrthoDB" id="2932980at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="321" mass="35151" checksum="8F59A3F67DA2BFBF" modified="2023-09-13" version="1">MSAGYFPRREKVGLEDLFKGLVTASHILHHHGVLDAYGHLSVRSPDNPATFWMPCNMPPALVSTPDDLVEYKVDDASAVEKDAKKGYLERHIHSEIYKRFPNVNAVVHSHCSEVLPYCISGVPLKASTHMAGFLGSNVPVWDISSHYSSGAKHDLLVRDSQLGASLSAAFKPATSAGFLYSKVRSALPTQIGGSQEPDKEPNYSTVLMQSHGFTTLAHGIEDVVYQAIYTKEAAQAHTTALTIRNAHFGHTIEGNIDVQGGGKIKSAKVKAESDLTFLSDREAHDAWESNQGTVHRPWALWCREVEVCPLYRNGCPGCEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD08</accession>
    <name>A0A9P4PD08_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_330253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD08"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2442765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="167" mass="18726" checksum="B16FB8A0C1C30A8C" modified="2023-09-13" version="1" fragment="single">HFTIKFAFLAFYVHLSPGRTFRVLVYVRAALNASVFITNELLIVLRCQPPKEVFSPGSTPDAKCMSQAVTFWSPVVFNIIVNVYILILPIPVIWGLCMPARRRLAVLAIFSSGFSAILTSAFWVFAWGKMRAHQTSPALAINTIISFVELFFAVVAINMPTFKPLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD68</accession>
    <name>A0A9P4PD68_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_434888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD68"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="242" mass="25716" checksum="78F6DA6BD3F609E6" modified="2023-09-13" version="1">MSARGVDYYKVLEVSDKASQQQIRDAYKKQALKHHPDRVASDSPERSARTKRFQQINDAYYTLSDPARRRDYDSTRSYQSFAGGAPDPATPDFEEEIPRQSNAGGGGAGGGGAFGGFPWSAFGFGSAPGGDTEESHNRFSNDQFGGVFEEMLREEGMAEGADAHPTGKFWSMIGGASGAAMGFIVANFPGAVAGAVAGNRLGAVRDARGKSVYSVFKELPQADKARMLSDLAAKVFAHAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEZ6</accession>
    <name>A0A9P4PEZ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_77655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEZ6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040489334" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25639" checksum="68BA50BFFF040EDC" modified="2023-09-13" version="1">MWWGGSWLKTILARGMCCLWLAKCMTKDEVCGSGLAWVAVEKEKKISACVGLVVCRKHQSCSACVHCLKRIRIASNVLVFGTVAGLQTITRKDIHHHPKGHGKTIRMGGMGGINLTLVRGLGLHTSLTSSSKTWPHQLSCGLVVLQKQLLEKSMARGGVKAVDEGGNVVPRVGVLSKAPTGSMRSNPSTKCTHVLLLCLSQTHAQDGLCVALRRLSKKHNNHFQGRAERDFGCGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFE3</accession>
    <name>A0A9P4PFE3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_445532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFE3"/>
    <dbReference type="OrthoDB" id="10451512at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040434746" evidence="1">
        <location>
            <begin position="16"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="178" mass="18412" checksum="3D11C591FA5A9FA7" modified="2023-09-13" version="1">MRSFIVLALAGASVAAPFKYYHLQPNPSKPYPPGGWPSYTTGSPVIPGPTGTGIHLPPIPTGVSPPEPPVISTPDIPSISTPSIPSGTGIFPPIIPTGTGTPYYPTPAVDRRGLEIDYKLAPRIPDGSYGAAYHPHPPPPHGTGYPHGTGKLPGFPFPTGTSGFGIPTALPTSPVHIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFM7</accession>
    <name>A0A9P4PFM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_362858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFM7"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2443037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="551" mass="61232" checksum="F01FDEBC0CA5023B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFV1</accession>
    <name>A0A9P4PFV1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_494555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFV1"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="41570" checksum="95AE94BDA4EC3096" modified="2023-09-13" version="1">MDIDPPKSSWTPEMALRSKAQVRLEEWKTLDIQEAWRKQSEYMHASAPADLRTWTTLTLPYQAHSNQPLPSMKEIRGASNLDAINGGHHEAENLLFLAEKRPELRIPTVLAVWPTTEEGPRVIYCLMINFIEGIPLDDEKFAELPIHAQDTICAKVSSQIRYLRELPSEGYYGRVHGQGWLCPPTGIELMTSTSDVVRGPYKTYEEFISAIYLAHQVQRAIANISPEWHPKEVERTAKFRSIFPDWNPHEPKLTWIDPKIDNMIARQIKGDDGSEDWEVFLIDWECTGWYPAWVQGLQFDFRGNILIRDYTQPVIKGHGPSFKSHREPAIQQMMTKDFDPNPDRERLDFIQEVDWHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG96</accession>
    <name>A0A9P4PG96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_49432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG96"/>
    <dbReference type="OrthoDB" id="10450499at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="377" mass="43115" checksum="7B27881024085026" modified="2023-09-13" version="1">MIDAALAEFFASDGKDTGTVYQCKGSNDQTLRAFLPPFNGFPSHVVLYEVESVASGPMLKREALRSVPLLKKSKWVWEQYLEARKRDSRYGRDLALDELLDRYRNELKNWRERNGNGLNMLGFDVEKAVKEQLEADNAQDKPMRDFLLDVLAVDHQLDLDDQTKQIAESHSPPYSCLDGATNADFCARYHTHGDAPCHTTFPPRATPEYNAWHFYENVAPSKPELWDGCQNVAAAREMFRGKMQKAFAEIQSDRWYRATYRLARLPVLPKIELEPIGHTYKIEPIGETLASGLLQNNLEGRFGVPLRDMELWVGVLSGYAEDLDKNRKWNPSLTGDFNNVQKVLKLFREVRDKGEVLQLDQPFPDPYALVDLNTLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH16</accession>
    <name>A0A9P4PH16_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Linalool dehydratase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_455921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH16"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041411">
        <property type="entry name" value="Ldi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18566">
        <property type="entry name" value="Ldi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Linalool dehydratase/isomerase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="505" mass="57746" checksum="515168D43D7069C0" modified="2023-09-13" version="1">MSRFEKYAKLTREQCGHIRHFHNLASLPPGDWAHMGSQEPGQEWDTAYRYQLATMAYAAGAAHYHRLPAMRSMFKEVLLKLIGKMMRREVWGYWYLSSQSGIRLNPDLKELRKPWADPVRKENIMYSGHLLLMVSLYTMLFADDRFDKEESILFDWNPMFWGMGPEKFSYTRRSLQKAIIDDMERENWMGVCCEPNLVFIVCNQFPLLSMRYNDATDEAAWAKKNGFVGDNGLFKLFYATGQDWVVESNNISHTVWAMVFMPWNLDLVKALYPQTGYGYLQRRGDRLNLNSQTLANKIRELNQTEGADPESSATIERAKELVAGQPQSSMPYLSPTFGYIAQWLSEIENGNDLAALLRHADADQGWDGDGNYTHGEAYTGNAGIGYGRPNVKEGQRKMWEKPWTKTEVEARPWVDGVALESGVDCLRGVWVEEERAMLLSLRTWDGHKEDVRVSVNALPDTTWGVYVDGQLVRIVDVSPKNKTVTLDVEVSGEPVDVVLLELGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI24</accession>
    <name>A0A9P4PI24_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_39984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI24"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000007">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="61"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="353" mass="39008" checksum="7C4ADA884AF41F81" modified="2023-09-13" version="1">MAKAESSKAAASNGIKANPNAQGGANYELPWVEKYRPVFLDHVVGNTETIERLKIIAKDGNMPHVIISGMPGIGKTTSILCLARQLLGDAYKEAVLELNASDERGIDVVRNRIKGFAQKKVTLPPGRQKLVILDEADSMTSGAQQALRRTMEIYSSTTRFAFACNQSNKIIEPLQSRCAILRYARLTDAQIVRRLMQVCEAEQVQFSDDGVAALVFSAEGDMRQAINNLQSTHAGFGFVNGDNVFRVVDSPHPIKVQAMIKACHECRVDDALTALKELWDLGYSCHDIISTMFKVTKTIDSLSEHAKLEFIKEIGFTHMRILEGVQTLLQLSGCVARLCKINMQPQLFVLPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIN0</accession>
    <name>A0A9P4PIN0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_463390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIN0"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="10"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2444750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="475" mass="52670" checksum="8E22BE29AD9F56AD" modified="2023-09-13" version="1">MAADSYTLGIALFAAIGTFLFGFDTGIATTTIAHQSFLDYMDHPTKAITGAVVAVYIAGEAGGAILQTLIGDQLGRIRFMQLMCIIVTIGTVIQTASINMGMFLAGRVLAGLAVGGLVSTVPIYLSEISAPQSRGMIGGISGCGISFGTMVSNWVGFACSYAPYGPQQWRLPLGVQIPWGIIMFVGLTTFMPNSPRQLIRQGKVELARSEFARMRRDLSMHEANEEFAHMDAQIKFEMEREITSYREIFRIYRHRALVSIAYFQTINYKSLGIEAHMILALAAIYGTCAFVSNAITTRYLTDQWGRRKMILWGLGGIVVIEIYAAVMQREFQDTNNRIGKGFAILGIYLFVVWYYGLLNSTTWLYGSEVLPLALRSKIMGCAAASHFIVNVAITEAAPTAQAKLRENYYYVFVACSFFFFIVAYFYFPETRLKSLEEIAAAFGDEVVSVDEYTVEAEHQKMVENGPEGEFVERMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ89</accession>
    <name>A0A9P4PJ89_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_519678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ89"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerases I and III subunit RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="46"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="134" mass="14990" checksum="03E2F71ABE76E55B" modified="2023-09-13" version="1">MSAKPIIQGQEFPVITPTSIKDIDEIPVSVDQARVTVLPGSTKSAASFQFEGEDHTLGNALRYIIMKNPDVEFCGYSIPHPSEAKMNIRIQSYDDVDVHDILDKGLQDLMDMCDVVTEKFTIAKEEFHSNKMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK14</accession>
    <name>A0A9P4PK14_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_268846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK14"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="334" mass="35826" checksum="D8E565EB276CA4E9" modified="2023-09-13" version="1">MATMSTKVMSLSSTSGAPTPPTTTPYTESASSSDNVAQPDFDAVGRILGPIQEDLNEQADVAMLPSPPINTPELFSPAPSVVYRPHRSRGFSLLGDRLAQLKLHERGSPRRDSDCASSNYSIVTSVEDETENIEDDASSTGRSVTWSVPGYAHSINKNVAPLISPTPGAIPIALGSARLNPRIEEYVQFSSKDLPVTGPARGNTSSTQAIPANNGSHTRDGSFDTIKSDGAVSGVTEKSTWAEEVEEAAERALLRLEQLAFDECARNPGRSMEEHFTERLQRLLAKRDRKVKLTVSYDNYVVKSASSSTISTEASTEVPEEPTNDSVIEAVATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKN2</accession>
    <name>A0A9P4PKN2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKN2"/>
    <dbReference type="OrthoDB" id="5280080at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="17085" checksum="C0B1D156AFB61C6A" modified="2023-09-13" version="1">MPSTAPTLPPNVTIFSPKNPAAAQNLLKASRFTRLSASASTTPEQLSKALSSHNGINETFYSSHGHAILIFDGGREGADLEDAHHEHFRAVCLALKDADIGLDVAKCVHDAESVLQAGYQLDAMKDGSVLVIDLMHAEDDDDDDDSEEEEDENNAKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL47</accession>
    <name>A0A9P4PL47_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coagulation factor 5/8 type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL47"/>
    <dbReference type="OrthoDB" id="5186230at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040339408" description="Coagulation factor 5/8 type domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31300" checksum="EBEF73D0599A0D87" modified="2023-09-13" version="1">MYLYYLIKILLFELLLRPAFCANIRAIYLFKDVLKSNTTSLTTSNFNSLIIFGVGILDDGSIMYYSNTPGSTDVKVASNGAYTGGAALAAKMQSLKAAGSSVTRLEISMNSQHVKELMAKPGPGTGTPLYKNFAALKTAWGLDAVNNDDESLYDVASTAAFAKMLGAVGYKYTGAPYTNAGFWKALIAQANAGRAEPDLLFDRAYLQCYDGGAGNDPSAWASSLGLKVVPLVWVTNDSKPSYGTTAAAAKTKFQGWKERGGVVGGGYWNDYDIEKMGLSYREYGDALGSVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLF7</accession>
    <name>A0A9P4PLF7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLF7"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040261897" evidence="1">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="331" mass="37205" checksum="882A432E4DD1476D" modified="2023-09-13" version="1">MKLSLVVSYAFTACVALAHSHAKITLPAPTHRLSRRFDADELASDEDWKDASCKGGRLIGLMLGTDEEAGPKIESTKDNNPPSAKSEWQGDLKQELKTWGWHDDYVEDVYADMDYLDVTSVVEALRINGKPKGDGGNNIAYHIQHMDPNANPKDKLQTYKVDGKEYRATNARHIFVVNPIDGVIMGQFLESPASAARMAWYRQPTSEELPKLQRLSDLFWGYWVRDNPNIANIRYFWMVDIANEDTEEILARALSEANKKIGKWPGVTFDMDSDAGKAILGSANGAVFAWFLIQHKKQLGDKWIPRVTVFLNDIGRSFSGAHILFYVEDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM83</accession>
    <name>A0A9P4PM83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_462905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM83"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="37"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="213" mass="22878" checksum="7884C6CC00B7B552" modified="2023-09-13" version="1">MDKLDKTVNQDLVSRLKLAATVYDKHQILAKDEDWMYDFNSAHPTESFKPGSVKNANAATFPAMVGHGMTIAQLNLGPCAMLPAHYHPRATNMVIAITGNTTTWMVNENGVRTVSTTLTPGKMTIFPLGSIHSMQNNGCDDAYLISALNSEDTGTMNIAGGLWSIRDDMIRAAFGNPTMDVQATGKNIPGVGTGSVYGSDECMKRCGMSKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMD7</accession>
    <name>A0A9P4PMD7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_386182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMD7"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="904" mass="101702" checksum="69D43A226DF6253A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMH8</accession>
    <name>A0A9P4PMH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-C2HC5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_429711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMH8"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="238"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="536" mass="57975" checksum="4C1CD90AAAE99083" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PML4</accession>
    <name>A0A9P4PML4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_482613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PML4"/>
    <dbReference type="OrthoDB" id="10653028at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="235" mass="26728" checksum="F2C17AF684392118" modified="2023-09-13" version="1">MNDRSAVVITPQVNLDGTDEGFDDLLSTPLTGKDLTANVQKLSFAANSWSGKLTLYKRAPGLVQQVEAVITAITKRLPPYFTKRWLQSASDQPTHDAILALIFWLATDLEQLDFTFTKEEEFPLTKGILGWDWRLVSPNLTAPRPFWKLENFRLICNGHLGDETYSMRSCISITPSLEHVSLNRISTGQDKIGIYWPLLTYYLHAVLGTLLKTLEIHNVNFKMKEIELLFDRLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMP1</accession>
    <name>A0A9P4PMP1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_518955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMP1"/>
    <dbReference type="OrthoDB" id="2430277at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="502" mass="49864" checksum="65B6CB12BCAF4BE8" modified="2023-09-13" version="1">MPAPPPPPPPPMPPMGRGAGGPPPPPMPGRAPGGKPPSGAGRGALLGDITKGARLKKVTVVNDRSAPIVGKVSDGPSGPPVGGAPPIPGMGKAPAPPSGLAPPVPGNRGRSNSDTGGDGAGGGSAMASAPPQLGGLFAGGMPKLRKAGGVDTGRQSSPHLSDPETTRGSAPKPPQGAAPKPPGAAPPIPGGRPPPAPGIAALRNNLRPASVTSTHSMSDIGSKPKPPLPGKKPPIPPPSSRKPSGLAPAPPATPARAPPVPGSAPPAPPPPPPSSSPLAPPPPPPPPPASTPSAPPPPPPPTAAPRAPSRSTPPPPPPAPPPKVQQDDDDDDDDSDDDDEYDPYRHTNTPPRPPPAPAPPAPKAPTNGTPSLAEQAARNVFGRSSPAAPPPPPPSSAPTPHSAHSVSAPPPPPMSPPARSTSQALRSMLDPSSYTLSNGGSSIKSPTSPAPGQKGKIIPVHDLRWRFVDESQFPRPREFLGGPKKYRAGRGSSVPLDLSAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMV0</accession>
    <name>A0A9P4PMV0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_429842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMV0"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="312" mass="33987" checksum="DE689DC8D888F133" modified="2023-09-13" version="1">MAPSAQFNPAADIPSLAGKVILVTGGNTGLGKQTIAYLAAHSPTRIYLAARTASKAESAIADIQREVPSAVIEYLPLDLTSFSSIAEAASAFKSREQRLDILVNNAGIMMTPFSLTKEGYEIQFGTNHVGHALFTKLLMPVLLQTAEQPGADVRIVNVSSMGMMLAPSGGIIFNQADLEKEYTWRRYGQSKLANILFTQELSARYPQITSVAVHPGVIITDLYNAFVSGPILKGIFWFYQQLVPILPGHFKDTKGGALSQTHLATADKSTIQNGEFYRPVGIVTKGSSYSQDLGLARKLWEWTEEEFGKHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMZ5</accession>
    <name>A0A9P4PMZ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_519804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMZ5"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="175"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="352" mass="41659" checksum="444A3FE5B2C9B63E" modified="2023-09-13" version="1">MDLVLEAFDTFLFDPLYATFLPAKTPGLAPNGTYSSFKEVPTAAPYTAQNTWTYEPASQYLSFEPGKYAYMSQWPRDDWRRQLVTLFLITWIFGLLIYYVFATLSYVFIFDKATFSHPKYLKNQISLEMRQTNTALPIMAVFTAPLFLLEVRGYSKIYDNFDEAPGMWYNYMQFPFFLMFTDFCIYWVHRGLHHPLIYKHLHKPHHKWIMPTPYASHAFHPLDGYAQGLPYHIYPFLFPLQKFAYVFLFIFINIWTVIIHDGEYVAENPIINGAACHTMHHLYFNFNYGQFTTLWDRLGGSYKKPADELFQKELKMCQATWKKQNEDIDKMISEVEGSDDRNYMPDEPKKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNH5</accession>
    <name>A0A9P4PNH5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_409699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNH5"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF5">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040514909" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="42"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="489" mass="51358" checksum="8E0D68C9D4ED2A14" modified="2023-09-13" version="1">MHSNIFAITAALAATASAFDCHGPYFSFYNRHGPAMSSQRLDPALFPGQQSPHMHDFDGGNGLSADVSYESLQGSDCTTARIKPDKSLYWRPALYWNGNGTGMYPVPNSFLKVYYKFGDNDNTKAKNISEFPEDFAMLAGDPFRRSEDEKNEAGIDWTCIGEDYSRITSKGFPTGFTSCGQGLTTQLTFPACWNGNAIDPKNPNAHMAYPTGGGAGIDACPEDFQAARFPSIFIEFWWDVKAFDGQYSANDNPWVLAQGDPTGHGMHADFRNGWAKGVLAKATSDDGYCNCGCGCGDEQMRECFGAENVNDDNDISTCAAKSAFADEAGVVEKLPGCNPIQAGPGEATAVSGPDCTAAAAPSAGEATSAVASATSAAASVISSAASEAISAVSSIVATIADVESTIIPESTASPTPATTLVSKSRHGHHQYHTAVPGNASEALPADAESSGCTNAATVTVTPPPVTVTVTATISGQAGYIVDKRRRRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNR0</accession>
    <name>A0A9P4PNR0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_429213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNR0"/>
    <dbReference type="OrthoDB" id="5403091at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="106" mass="12469" checksum="4E4639521DF69848" modified="2023-09-13" version="1">MLKIRIAVYQALESRNYFPPPVQGSKRLVTIQFCSRSFHVLIAKAHLDSGRMFVKPEFGKRSPTGFTPWRWMFWFKQSTGFETTQQKRMINSRRGIPAMQSIRTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQG6</accession>
    <name>A0A9P4PQG6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_352774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQG6"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="7"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="359" mass="39036" checksum="C40CA335A206630E" modified="2023-09-13" version="1">MKAIKIEDKKAVFVTDAVLDSNPRPDELLVKVVAVALNPTDWKHVELGITTRPTVGCDYAGVVQEVGPEVVRFKKGDRVLGIVHGSNQVRPDNAAFQEFVYAKEGLTAHVPDQMSFEAATLGVGIITVGQGMYQEMPIPWPDRPLKEKVPILIYGGSSATGALGIQFAKLSGYEVITTAGKSNFDYVKSLGADAVFDSRSPTVGEDIRAYTNDKLYYAWDTIGEHGSPETSAKALASNAPEGQKLYYGTILLKDIAHFIERDGKFEARPDDVVLSMSLGYTAGGEAFKYGDLEFPVRPEDYAFAKKWTPFASDLIAQGKIKPHRAEVREGGFKSIASGLEDVKNGKISGVKVVYRVAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQT0</accession>
    <name>A0A9P4PQT0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_352204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQT0"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="337" mass="36366" checksum="7056EEE939571299" modified="2023-09-13" version="1" fragment="single">GMFTGRALDAGFFHWVVVPGMLLSALGIFLTSLCSTYWQFFLAQGLMNGIGNGCQFAPSMSLVTTYFARNRSAALAVMACGSAIGGLLYPTIVRQLLPQLGFPWTVRVMGFIMLAVGAIYSSLLRPRLPPRQSGPLFELSAFREAPYTLYAIGLFLVCLGVYFAFYYISAYAVNVIGVSYGTSINLILVLNGIGLPGRLIPGYIANRWLGPYNTLIPLTFITSLLMYCWAAVKTKASLYAFTVLYGFFSAGFQGLFPAVMANLTKDLSKVGTRNGMGLSVVGWASLCGPPIAGALIQRGGGDYFTAQIWAGTVMLVGSCTILAGRVCITGWRLRERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR04</accession>
    <name>A0A9P4PR04_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_428611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR04"/>
    <dbReference type="OrthoDB" id="427960at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="241" mass="25464" checksum="83EF61BB83E94AE1" modified="2023-09-13" version="1">MRMSNGGSAASTPGAPSDREIVQSALAAEEKKREEALARAYAHTGETKWVLNYKDPHAGKRPPMMQVRQAGFAVIDADGDSDEEEENKPIRMKFGGGLKKKKAVKPDIDQAEGSGSGSGSESGSESSSGEIDSDDATGELIRETKRQIAAKERHARNAQKAAAVTPVRRAAAPIDEDMDLAGLTSLSGGRPSAGRDMSKVECYGCGKRGHTKADCPNSGSRSSGPPGMRGSQGRGRGRFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR11</accession>
    <name>A0A9P4PR11_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR11"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542:SF2">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="167" mass="18656" checksum="692E603090539477" modified="2023-09-13" version="1">MTTAIHVGPLPSGIILQSIAACPPKDRESLAAKLAKLEKKIFPSSEAFDYGSELKKKNVGIILAVKEGTQELVGYLVYQRQKSLAWLHKLATIEQERRKGIAKCLVDFLCQQMKKGGCRTISLWVDEVRNPARALYASCAFQQIERLPEYYGPGRTALKLELNIAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR65</accession>
    <name>A0A9P4PR65_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_351966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR65"/>
    <dbReference type="OrthoDB" id="2285533at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF9">
        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2449785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="379" mass="41601" checksum="027F0C4695D44EBD" modified="2023-09-13" version="1">MSKSPLTRSKIYATSEERKQRNRQAQAAFRERRTEYIKQLESTIKHHEETLQNLQQSHRSAADECLMLRYKNSLLERILLEKGIDVQAELQAKTGSPNLGPTRQSAPATASPNQPPLQQRAMLNRQQQNRRSLGGLSKPEGVHSLPMIQPDGAIPNRSPLSQPTPGSHLPSPVASATRSPNFIAQGTSVSPNFGSIPPQQQPQRHQQLQPQPPRSQFTPILGPQRPSVITNQASSNGLSSASTGSGASVMTQSSTAGGPQSYFPTPYSEHMTQLGKLSQQEYDEQNDMLDQEDPSDHSAGPGPYPHPFQSNSMQSQSMQPPMPPAQNPPYTNNGPVSANDANHAFNGMNHLFDPYDPMLDADPFGLSASMHFPTMYESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRW9</accession>
    <name>A0A9P4PRW9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_479297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRW9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="157" mass="18338" checksum="7B9FB924A38747CD" modified="2023-09-13" version="1">MAHPYENWEYPKDFEGLVTKIGGQAQVDEVHYDREAFRRWKESSQARNSKRAREECDVSDEDNERKKLPGFSRNEQARESETKRARKDPGDDDLGGQLPEFSMEAQTRVGEVKRTRKESEDGDDDDDELAELSKEEFHHNLHIKSEVPEEEEGDQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSU7</accession>
    <name>A0A9P4PSU7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-dependent metallopeptidase Hfl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_469578</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSU7"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="354"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2449562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="791" mass="86211" checksum="7E429B107EA0688C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT72</accession>
    <name>A0A9P4PT72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_406490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT72"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF203">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040313782" evidence="1">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="239" mass="25498" checksum="E25CC7550DD1E239" modified="2023-09-13" version="1">MSIRSFLPIALALALLLPRALGHQHHIRSDSNALAQAPLAINGIPPSTRAHWMRKANEALQHVHGDPCPFGAFGAAIVNHTAPGLGELVCIGANSNRQTGDPTLHGEIAAIQNCTRVLTSPSGPYNLTSPAALAAFSQLSLYTNAESCPMCASAIRWAGFKEYIYGTSIDTLVEKGWGQIRIGSMEVFRESFDLGTATRLIGEVLTNETDVYFGWQYDLEAECPEGCGRVGSSCKAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTJ8</accession>
    <name>A0A9P4PTJ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTJ8"/>
    <dbReference type="OrthoDB" id="10532594at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="447" mass="49133" checksum="A54FFDD1EDEB37F0" modified="2023-09-13" version="1">MPRDEMPGTSDGTREFKGTDKRSNRATEVFTSAPMDDMTSQLSATSLKGCPCCCDDCECAYCCCGNCSERGQCNCTEPCKCAGDHCPLPCGGCCPDCTCPMQKPLKKDRRWSDNMFCLVPGPGRVRLESYIMKDIGVADWRNGQRRGRSHSPRTDDDHRSYRNCDHNYGLWERGSCQSPPPPVQATASHQICKENSTDKLFDALYLSKDLPFPREFPVVFPVYRLNFPWRGRRRTGIDSRWNRFPFSRSRSPANQEVEMPAGGGSDEPTEADTTHHGSPPVPSGAGAHQSHHRDSPVPSEAGPSTTAYHSAPRSRTETIVLLLAGIESIQAQIDNLGSDTLDPIQDQVNILRRNTEYLALQMGDPARSPASTMVTLPIIDDVPEIPQDGTSPATRSAGSLPERPRYLRTPSPPTPNESSASHSSTSKCLPPARYGAWFDETGQAYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTP3</accession>
    <name>A0A9P4PTP3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_377191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTP3"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
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            <begin position="7"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2450241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="452" mass="50171" checksum="FCDEE078CE0AC698" modified="2023-09-13" version="1">MLKKVYCTYIPTIVGFLVCFASATTVPAEAQFVSEFHVSSRVALFPFSFFTLGLAFGPLLAAPISENYGRRPVYLLGLLAFSFFTLGAGFSPSFTSLVLCRFFAGAFGGAMLVVGFGFLADVWTTKQLPVALSIFNVVPFCGPAAGQLVSSYIIPQKTWAWTQWPTLFLAAFIYLTILPMPETYRTANNSTIQTLNEVKQKRFGEYIKSLLAAIPFVRPLHMLIHEPVVCLFSLYIAFNFTAIYCFSASIPFVFKTQYGFSLQSQGLVFTGLIVGYLISGPTMIFPYMKQMQKNQAANSSSANIEPFENGTQPESLLWPALIGAVALPVSFFWFGWSAEAQVHWACPITALGLYSWGNNLLYNAAQLYLLETYGSRYGASATAANNLLRYIWAAILPLFMTTMYSNLGTGWASSLLGFILVLFVPIPWVLRYFGPKLRSRSVYLQTDEILQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PU40</accession>
    <name>A0A9P4PU40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_516214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2450300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="702" mass="75488" checksum="6953786E9C1341ED" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUA9</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="165" mass="18359" checksum="9779983C6B2AA8A6" modified="2023-09-13" version="1">MTSLLNKLFHSITASGKKQNPYTDPHHVYHPSTSQPAPTSTTAGHVFSTSPPQAWQPLPPRPTSPREPYDYLAEAREASGRDAVTGQPGNQSGGQSRGDREEERGQRSVYQETSEGRSKTHGTKYDLFVQEMKARKVGRWRAPDGGFYAPERRLGEFYQPERSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUC1</accession>
    <name>A0A9P4PUC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenazine biosynthesis protein-like protein PhzF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_460067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUC1"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="311" mass="33675" checksum="9B3DF31444219BB2" modified="2023-09-13" version="1">MSPTSENLEFAIVDVFTDKRYEGNPLAIVRLPASSKLTQEQKQNIAREFNLSETTFLHEPTGGESCVWTVDIFMTQAELPFAGHPTIGTACLALSEAAEKDNAEGIVRGTFNLKAGPVQLQYDTASKTAKAAIPHDVHVHKRVWTRDELLAQQPALAEFAGDNQKIPIVSIVKGMTFVLIELESLDALQKVQLTTTVTVDGLDQGWNETFVGTYFYVQTSNSGGVRQLRTRMIEGSLEDPATGSAASDLAAYLSLLDGKPGQTLEFAITQGVEMGRRSEIAVSVLMGTEKGIETITLGGGAIPVMEGRLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV82</accession>
    <name>A0A9P4PV82_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_151519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV82"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="173" mass="19560" checksum="52241A70FB53A003" modified="2023-09-13" version="1">MRVSRKAIDKCGRGRFACVGLAFYDRVSRWRAEQDKTRQDKTRQDKTRQAKPSAYRDAYPSHQRRRMPKRTAGPRHASRHASIHPDEPGHAQAAVHLHRAPQRRSHLGAENPRPAAAAAAAAAPSQRSVPKNNTRVLERLDDQRCWSPSWRKVQSCCRVKGGQRRASGVCART</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVA3</accession>
    <name>A0A9P4PVA3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_426436</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVA3"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040534606" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2452034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="460" mass="48946" checksum="B9976DA810CE72CB" modified="2023-09-13" version="1">MKTSAITVAILAAGAAATPAAPLAPRASSLPTVSVKGNAFFAGGKRFYIRGVDYQPGGSSANEDPIANAETCKRDVAKFKELGLNTIRVYTVDNTADHDECMQALSDAGIYLALDVNNPKYSINRSKPARSYNKVYLQSVFATIDAFQKYDNTLMFFSGNEVINDDKTTECAPYVKATDRDMRSYINARGYRKIPVGYSAADVSENRMQMAAYMNCGPDGARSDFFAFNDYSWCDPNTFEKTDWGMKAKNFSDYSIPLFLSEYGCKTNTRTFNAVSALYDTSKMTPVYSGGLVYEYSEEADNSGFGLVKVQSSTEVKDKDDFKALKKALSENPAPTGDGGYKTDGKPSECPKKSSTWDVDLDDDKLPAVPEGVEDYMKNGAGKAPGLTGGSQDSGSDKVDTAPAASGAVTTGASESGGASKPTDSKGAAAGALAPEFSFAPIACGLVVLVSSLFGGSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVJ5</accession>
    <name>A0A9P4PVJ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secretory phospholipase A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_322717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVJ5"/>
    <dbReference type="OrthoDB" id="5120271at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015141">
        <property type="entry name" value="PLipase_A2_prok/fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09056">
        <property type="entry name" value="Phospholip_A2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14977" checksum="41D8C3C65F275A4B" modified="2023-09-13" version="1" fragment="single">LSTIAVLVSSVAAAPTPPLEARETAVEATDRLVFRATLKTFISARNAQSPATLDWSSDGCSSSPDNPFGFDFLNSCYRHDFGYRNFNAQARFTDANKLRIDDNFHNDLYNQCAKQSFTSICEGLADVYYAAVRAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVZ9</accession>
    <name>A0A9P4PVZ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_451965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVZ9"/>
    <dbReference type="OrthoDB" id="509690at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040210067" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="353" mass="37443" checksum="00CF442B7CFAF491" modified="2023-09-13" version="1">MLFTAAFCFATLALPLHASTIDYKKAWTTKGDKIPNFSFAGYHESERALPSLSTSAKKTLSPGSGDQHAAIQAALDDVSQDGGGIVALKAGTYPLSSGLLIHNGTTLRGAGIGKTILTVKDLREDVVTLGKTSGKEKMGKSIKITDDYVPAGTGTVHVADASGLSQPSEIGIENLSMRVKPSCSGRILNDIACSSAAVLVPSWTTNSWVRNLDLTGFNNHIGVLESASRITITMVTMNRDGPTDNRKGYALDIAIDGTQVLVHNAKTLGKKDARSYSVATQSVTPGPNVCIGYEAEQAVESIEPHQRWAHGFLNEGSKVAAVFYRNRGGAGSGHGWTINNGQFIFILSSKFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX46</accession>
    <name>A0A9P4PX46_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX46"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="260" mass="27596" checksum="0C9AD9FD0280080B" modified="2023-09-13" version="1">MDSMATMSALMDATAATGGAEVTTLGTDPAHAVATDALSSTSPPPQSGLSLNPALAPSSTARTHKRNPSLSLNPELSPSLDAKSRNSTDATLSLGATHLASPTTADAPTTPPFSPSSTTPVLENPELDFEGTVEVNNDIPSEKDMKRVDDLLVLDSSGESRPFRDLYKGEGVAPRQLIIFIRHFFCGNCQEYLRELSASITPESLLALPEPTFITVVGCGRPELIDMYAQTTQCPFPIYADPTRKNPTCSSPRCSPSCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX55</accession>
    <name>A0A9P4PX55_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_427143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX55"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="329" mass="35513" checksum="52D59F16AF7FB8DC" modified="2023-09-13" version="1">MAPANPPKTIAGKPVGSVGFGMMNLTISGKITHEEAIKPMKAALENGANFWNAGTFYGPPTANSLHLLKYYFTKYPEDASRVVLSVKGAYDMRSQVPDCSAEGLRAAVDEALRVLNGTKTIDLFECARIDPNVPVETMVSTLLQLIRDGKIGSYGLSEVSAATIRRAYAVHPPAAVEEELNLFSRHVLDEGDVADTCRELGIPLVGYSPMGSGWLTGQFKTLDDLPTGDYRHHFPRFQPGAFEQNVKLAEAVGTVAQKKGCSSAQVAIAWVVRQGVLAIPGATKVHRVEENCNLVELTDAEAAELQEAVDYTAVAGDRYPEAAKKHLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXG5</accession>
    <name>A0A9P4PXG5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXG5"/>
    <dbReference type="OrthoDB" id="2587563at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="669" mass="72698" checksum="624FC211BCC0235D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZP3</accession>
    <name>A0A9P4PZP3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZP3"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000008">
        <property type="entry name" value="GAF domain-containing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="154" mass="16580" checksum="24F047A22C3348B8" modified="2023-09-13" version="1">MVHADSSHFTQGMSKKEVYAQVLEQATALFDGQRNWVCNFSNAAALLWHAYHSLPAPSSAVNWSGFYFTDPSNPRKLILGPFQGQVACQAIAFGRGVCGTAAETKFTQLVEDVEKFPGHIACDGASKSEIVVPIVKDGKVGSTSREALESGRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4N4</accession>
    <name>A0A9P4U4N4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_432203</name>
        <name evidence="3" type="ORF">P171DRAFT_437938</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001587">
        <property type="protein sequence ID" value="KAF2437195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4N4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="326" mass="33629" checksum="C96F2E216DE15DBD" modified="2023-09-13" version="1">MTLTNTLIYPRAFFLMCLAYIICAFHDIKQIPASSRDIHITALVASVLFTPSKGLPTARSLAKMPPKIAVSKPRARASASTPNPTPTGGGAIHRNEHDETYNSLFDESQPPISPSNSGSVRNGDDVGAGGHVGGKRLPNYDDGNGDGDQQGGDGVGQAGAAQVEQTSADGDNGDADQQDDPGHGQNNASGGSGGANPVEGGLRRSTRNKKATQSGVVPENVDEGPSKKGGRKKETGKGRAKSKKATGTTKQKNAKAPAAVESDDDGDEEDGGLADDVGVLLDDTITWLSDAARIGTRLGDSRDALVNVLKRRGAGGGGPGRKRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U588</accession>
    <name>A0A9P4U588_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_156243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U588"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="124" mass="13975" checksum="A16D3919709700F6" modified="2023-09-13" version="1">MVRSSQMADPLHETNLSRLSRSRLRGVRPRIRYRKQHPWSIVHSRFSWLRLLLAPGGASARGTCGVSRCCANMNGITYPRGILTTTRPSMRVGRVAMIIRLKQQVADIQSLSMLDLSLARCDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U618</accession>
    <name>A0A9P4U618_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_436604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U618"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="176"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="410"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="669" mass="75852" checksum="5D80E80CA0E147DF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6R0</accession>
    <name>A0A9P4U6R0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_436400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6R0"/>
    <dbReference type="OrthoDB" id="3911301at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="70" mass="7475" checksum="04064F3869DC0CF3" modified="2023-09-13" version="1">MFSCSNYERGCRGRCNHQGGRCDSCITLNLQAIRSNSASSMSSVNGREQAAYSAMTSSFASLAAASNRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6Z0</accession>
    <name>A0A9P4U6Z0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_436236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6Z0"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="18"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="374" mass="39919" checksum="5514F215DE84F079" modified="2023-09-13" version="1">MATKLPETMRGQFLEAYKQPYQLCTVPIPEPSHPDDVLIRVDAASYCHTDYVLAEGQMPGFPNSFPHIGCHEFAGTIVSHSARPSPDAVRFKIGTRVGVTGRAFHACRECFECQGCKDPIAEDEKGYSVHCTRAENNGISKDGGFAEYAVVDSRQLAPIPDKLSAAETAPLMCAGITIYAALKRCQLGSGDRVAIMGAGGGLGHLGLQYATKMGFKVLGIDAADGPLSLARSLDTGARIIDARSEKAADVVQQLGVEDGKRDLGEKGVDAVIILPESQAAFDYGMTLLKSHGKCVVVSFPEAGFHMSSRDIVFRDISIIGSLVGSNRTLREMLNFSADHGIRAVAKSFPLSGLNTLVEDYHKGGGGKLVVDMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7A2</accession>
    <name>A0A9P4U7A2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_434686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="871"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1205"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="760"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="807"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1120"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2440974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1433" mass="161489" checksum="2A8EB77B7D2825F7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7B5</accession>
    <name>A0A9P4U7B5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">chitinase</fullName>
            <ecNumber evidence="1">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_476851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="1"/>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7B5"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF337">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040426163" description="chitinase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="18"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="527" mass="55463" checksum="0125ADB65F684268" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7C4</accession>
    <name>A0A9P4U7C4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation chloride cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_366687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="138"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="628"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="1291"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1025"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1089"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1171"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1241"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1252"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2441049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1358" mass="147944" checksum="9CB158724DFA1265" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7D3</accession>
    <name>A0A9P4U7D3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_436803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7D3"/>
    <dbReference type="OrthoDB" id="5223508at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="304" mass="33838" checksum="B29CF0674F56A8D2" modified="2023-09-13" version="1">MPPRIPVRFPWAAREAPIINASLAARCFSSTAPTLALGPESPNYIEVPKPAQPTFALNSPVKGHLPVPRDVFKTRSPLSKASDDFIAQTTQDPKKVAQPGPWSKDAEYRLYKQRLADARKKAFREGVQELHVRKVTTDQAFTAQIEQSNAERRRLAMAPPRVVDVLTQTSVSKGIRDFLGDTLPSTPREVFVAQRKRAYQKRLLRQERVRRSRLHDLYTNAREFIVSEEQLDEAIEKAFGTDELPVRWHVGGQTSPTGTGASPWEAGVPEGVMERLQKLKGGEGVGLAKERVKKVAEALTGGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7I6</accession>
    <name>A0A9P4U7I6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_93359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7I6"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="569" mass="64056" checksum="9103045E99C5AB9F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U828</accession>
    <name>A0A9P4U828_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_368226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U828"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="580" mass="66885" checksum="11C2DE51470A50A6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U841</accession>
    <name>A0A9P4U841_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_525494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U841"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="218" mass="25150" checksum="DF650F2E95DEC525" modified="2023-09-13" version="1">MNNPERWFTTMELQNALSTLRRTSRVCRRRCERLLFRSISLDDTSTELMLKSRGLFKRLQDPNDVLSEHVPELLLGPFDNDGYFGTFRKALRSQVASEPRSWASHMQDKKTTEVVPVDLTPRLLSSIQQLLCEPENNSSESSFGAALWNNKGYKSYNEYRMVKNCLAQGNSIKRLTIAYHGPHVFLPPDDSAGGSALLHWNRVTQGPINFDWQEWCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8B7</accession>
    <name>A0A9P4U8B7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_106418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8B7"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040460406" description="Vacuolar protein sorting-associated protein 62" evidence="1">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38493" checksum="6FF217C25B1ED27C" modified="2023-09-13" version="1">MFGRKVFGLVALATGVVSAPTKRQAPSGVPDYVLKYAPVVYLHGSDPYMPSDINTHISHTTPRVNFNTVAAPNPLDLNSINQLGGDVYLTSNDDITTQPEWLKGVRPDGNGKTEGTTAAVIVNDKGNGDVDAFYMFFYTYNWGGEVLGLSSLNFGNHVGDWEHIMIRFKDGQPQAVWYSQHANGQAFKYSVTEKHSDNLRPIAYSANGSHANYAIGGTHDHTIPNFNLPGGVLEDHTAKDIFWDPLQSSLFYKYDAGANSFTAYDGTSPINWLSFTGRWGDQEYPESDKRQFKIFGQAKYSGGPTGPADKQLNRNNVCPDNGNDCILRGILLPRSAELDAQVFAEDVVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAB3</accession>
    <name>A0A9P4UAB3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_474339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAB3"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18687" checksum="7A163506B0299B4D" modified="2023-09-13" version="1">MTTTTPEAPENASQLYKTLFSTATEFIRCQDRDDSQPTRMNLDRVRAIRTPNHTHSFGHNHLVSTKPMLQGELGVDAFLAHVDKMVPKLDTWAARITDIVVDETRRMCIVRASYFMQPVGAEKAVENDVVWWLWVEEGGQKVKKAVEFVDGAATGRIGELLMAAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAJ0</accession>
    <name>A0A9P4UAJ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_433444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAJ0"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="2">
        <location>
            <begin position="115"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="284"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2443106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="512" mass="59025" checksum="2D0A468550442FE9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAT6</accession>
    <name>A0A9P4UAT6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_446099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAT6"/>
    <dbReference type="OrthoDB" id="3788617at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="319" mass="36199" checksum="ACE5E19A7E47681B" modified="2023-09-13" version="1">MSQNMLPEASIDESNGWTEHTETVARSPKATAPKSLLNIICGVKITRSRAQTVLEELKFMHDTMSMSLESIEEFKLTKPLAVNDKNKYLDHGEEYENGRVWRAISSFSTNPGPKAAIKAKLSVASAHVLLHENLEVLGLPSSVASSLWNEAGRIFRDYDFRDCRNFFSHAFLRTVYGNDLKYYQKVQTIYTSCVSVLEVLIEKLQAGLSDENAWKTEESELSHSERPEYGMDTPEAEAEAEEQRQIKASEVPVAAQQPGWVTEEEAIESSGSLVDQDPIAEDSIAAWLAETWDWNPSYGIERRQSWSHFYVDTHRRSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB86</accession>
    <name>A0A9P4UB86_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_51158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UB86"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="269" mass="30017" checksum="EF8653067ADECD20" modified="2023-09-13" version="1">MGRGLASWWREVVQEERWWVHEEERWCSWCSGRLLREVQRSEEGAASRGKKARPAEGGRRDQQRERAALLRADRQARRHAGRKTDDGCRAFQGPSGVRRNGHRLRCSTASCHLPPATATPLHYGIWLLASGIWHLASARCVPRGRGGVAALDSVPLTGLRAPRFTRFVPPGHAAESLAAGQPAGPSYYAPSSSPSPRLRAHCYTEVFSPSHVRFSGPNCCSLVSTTCPRLHLVSLHWLLRLRNHLTLFEHSLVPRYLATSSSRPEKLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBU3</accession>
    <name>A0A9P4UBU3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RCC1/BLIP-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_389324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBU3"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="284"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="348"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="424"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="605" mass="66739" checksum="FAC703D5F71F8684" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBX2</accession>
    <name>A0A9P4UBX2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_472687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBX2"/>
    <dbReference type="OrthoDB" id="3789824at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="234"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="711" mass="80266" checksum="B2687C016A71AC07" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC12</accession>
    <name>A0A9P4UC12_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_45447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC12"/>
    <dbReference type="OrthoDB" id="3693506at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1110"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="757"/>
        </location>
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        <location>
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        </location>
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        <location>
            <begin position="882"/>
            <end position="891"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="921"/>
        </location>
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        <location>
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            <end position="931"/>
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            <end position="942"/>
        </location>
    </feature>
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            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1171" mass="131462" checksum="2CFF9AC4049CFCDF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCF2</accession>
    <name>A0A9P4UCF2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_361404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="139" mass="15440" checksum="6AD8BDDC77B0D76D" modified="2023-09-13" version="1">MSEVDTGRTSTEGPSSPATSVSGPHVNGHLVYTGKYKGDKKVQRLFIHEKSPSTKQHSCRVYSYNVANQEIDGAPGESARTTVIEHGWFRDLAIFEQICANHPTPNGQAPQDEIFSSWRDSLLTFLDTHHSGSLWTRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCG4</accession>
    <name>A0A9P4UCG4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_387954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
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            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2445160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18802" checksum="83AEDF61FA10DD94" modified="2023-09-13" version="1">MTFKVEAANDADIGEILSIIFKCYRGKNEYINAVFPRALTEKGYQLNVERMLFIKSVAPSVFWEKVVIIETGEIVGGAMWNLCIQQKPPPYDIDGPPGTWETDDDKAYAQALQRSFAEDENKLWEENDLPLLGLAMMAISPDCQRKGAGSALLESGLKIADAKHAAGSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCH7</accession>
    <name>A0A9P4UCH7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_485298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCH7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="334" mass="37008" checksum="D4F8DEBF956BD106" modified="2023-09-13" version="1">MEATVTWHFFNTIYNTWNKNVPDGSQQEILWPVYGASTVTDEGVACFYGDYLKYLGPEMELRSFMLNSLISFKTQTNKWTNDTGPTPRAEGNIHYIPASEKAEDYSSYNFSVIVSSNDIGNLLTFAQLRLWWYFRQCSALADGTILTLPSFEWISSERQGHFDSVCVGLADKRSQRAPTRAILTRPPPPKKQKTKKTHTQTKAIAGGAVEGVVALITAVVIALCLRRRQRQRRNQTSPAVQNEQRNPSPIDHDKYLTSPTTASYPSPDVLSGHAAAGTAGYLGGLAKGQQAYYAVPQDPLQGHKYAHFGEASAELPGTEGVVSEFPERESPVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCN2</accession>
    <name>A0A9P4UCN2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_443026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCN2"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000008">
        <property type="entry name" value="C6 zinc finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2445340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="725" mass="79867" checksum="1DDA5C8344E815A3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD05</accession>
    <name>A0A9P4UD05_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD05"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27542" checksum="09E87640846D4675" modified="2023-09-13" version="1">MASSKPKPDPLSIQRGNYARTLAGPLLLGLGRTISIPLQHWVLTAHPLSRFGIPRPPIDGVLNLPLVGAQPQLSTIFLGMTATLILKQNAWIWGYCNELITTEFALFGVLVPAVYECLIALVFSGAFSNPLWRKEFLYVGAAVHFLAAAVELGSELARAAFKGRKENKGKLYKGGLFGVVRHPNYAANVVYGTAYGFAAGGPVGALFTGAFYWSNLTGNATPAKEKYLAERYPAEWEQYKKEVPYKMFPGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD23</accession>
    <name>A0A9P4UD23_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hexose transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_462506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD23"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2447364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="456" mass="49759" checksum="07E7697D0AECB394" modified="2023-09-13" version="1">MGFGVVEDRPTPPEVYNWRIYTLAIVASFGAEHFGFNDMSASAGTSTMSNITSTHLVAGFFGSLFAWPSSEALDRIRAMQLTCAVFMVGAVLMTATTSSLPMMYAGRVLTGFGVDALTGIIPSYIAEVAPTAIRGQLTGHFDVGSLVGFWINYGITKNMGVHSAIPFCIPLAIQIIPGGVLLLRTLILRGSPTLLWRKEVGRLEEEQRLSGGQTGCVALLRGSTAEMKTSSIRYRLAVTVGMFVFHNWSGSICMNYYSLTLFKSLLISDVALYTGIYGVCRSTAATAFYSFIVDRTGRRIPWLISTSTCSLTLFAVAMVMLYGIFWSLGGNGLPWIVAAEIFPARLRPITGAFAASLQWLFSFILTLAPPLCFLTAVFTFVWVPETKAVPIECCEALFSGKMRHAAWRAKKLFPPNGIPPLLNHIAEGEAAYIQAHRPSSPSDIKTKNYREEIESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDF1</accession>
    <name>A0A9P4UDF1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_483629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDF1"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="423" mass="46260" checksum="9F37E6BAB9A704F1" modified="2023-09-13" version="1">MTLDSCDGTDTEAGPALSASEQEKVAYQLFDEISESCANIAKEPNPPDTVNNGDYSSQDQQQDVGGQPLARGSSTVVHDTTTAAQRSGMTLARCENINTEADSALTTDHPDRELNRSLTLRDDPLALTQRAAVKPKETNSTSIAEEKSPNPTSSITLPNQGRGVGDQQQKKGENSAADPRLICGKCKRVPRKSGVWTVHCSGCKDVWYCGSSCQRAAWKSHAAACKKTEQPQSPLLNISTEAPELGARYDPDDEFNTALMPLSENVPCMICEGTQDHQPGCMAAEFQFGPVPEYNEVMLEEIRRRVEYFDPEQWREHGHRDILDPIDPVGPPEEESARDAILGLNSIIRNESSYQEDAFLHGVPDEWLPIMWALRTSENVRMQLVTENGEIYDPNHPVWDENGDVSGAGATDVAGSGSRDKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDG9</accession>
    <name>A0A9P4UDG9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_429430</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDG9"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="15">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="213"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2447829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="393" mass="43525" checksum="3831AE2EC5BC5227" modified="2023-09-13" version="1">MADDALLGDLCSICNTVQFKYRCPGCSARTCSLPCYKRHQQWAQCNGKRDPAKFVKKSQLATPAGIDHDYNFLTGIERGLEKADRQLEGQGLGSRPDPRRDGKGRLPSDQHFAEAGVTVIRAPKGLSRQKDNKTHRSKKQKHIVWTVEWIYEESDRVLTQSSSADTILQAQPFKEKNKKRKRATEQPTSALTSEPIRQDVSLPVILDEAASSVEAGQAQPDPAPTGGPKPERVDAGATAGHETASDASAKEEEVEGAKDHDGSIRSNGPDPESVSAKYAFYLLRPRTSSKRLVLIRLDPKATFAECLRGRTVLEFPTIHVFPESTSPPPEKFMLEAEYLQQEGEEQREFDDLLKQVGPETLRALKEEQGHDDMAGEPIDSDRILDVLKQDIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDM3</accession>
    <name>A0A9P4UDM3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_483834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDM3"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="437" mass="48529" checksum="B9AAD3CEF2739D8D" modified="2023-09-13" version="1">MPSDHSNILIVGAGIFGTSAAYHLSLTHADPSSITVIDRSPFPPHQAASTDINKIVRADYTTPFYMDLAYEAMHAWKTWPILQSKDGQRFFHQSGWVMLSDAGSDLAERIRTNLRARGSDLTSDVEIDGGIRERWGGLLKDTRFDDPKIEKGYWNPEAGWADAGDAVTKMLEEAVGRGVKYECGDVQSLLMGENGVKGVQTKDGRVYEADQILLATGAWTSQLLSEVEGILNIKDRDTIGKQVMAAGVCVVHYKLDDEEYERLKDMPVIVYGDRGEVLPPPSGSRLLKFTNARSFTNTARTTDRHRISIPPEAQQTVVSSPLQSETLDCIVSKTMPSFAARDPAYWRLCWDAITPTQDQLITRHPHPRLGNLNIAVGGSFHSWKFLPIIGKYVVNVLNGISNGEEKDGRWAWKDGTTHGRGAHEKVVPKRELNELET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDU8</accession>
    <name>A0A9P4UDU8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDU8"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="307" mass="34755" checksum="6CA87561E05FAD3A" modified="2023-09-13" version="1">MVEPSPGKGLGVFAAHTLETGSIIMREAPVITIKPPKDTPGTGYPLPVISQLVHAEYNRLSEAQQQDVLDLTYSVLPTDIQRYGDNLDILGIIFRNNAYDTGTEIGLFPKIARINHSCRPNAAYYWNEKLKRRFVYATREIEAGEEIFVSFISLLLTREERQKKLARYGFVCTCPACSQHPVDLHDSDRSRVDIEQALRAFSAQMNLTAPTHPSGVRKARKNAESSLLLAGLVEKEGLADYYAQTYRIAAISHARIGDWEKATVWANEGYKRRVMEDAESPWTMEMYELTRRLVEEWEAELKGTRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE78</accession>
    <name>A0A9P4UE78_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_429809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE78"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="204" mass="22754" checksum="1E81397BAC759FC3" modified="2023-09-13" version="1">MGQPRSTPQVEHSNAPLANPTVLLDTPDAFLQTLTPAELAGYLNGWHLFPDDTTPTDMGTLGAIPHVTYIARRASFLADDISIHSSPPSPAPPIPPVLLHCWNCHGVHYPTRQDVPWPIAPCQSIWGYDYSDHVQGAGGAERVGLLEQVQALLRWETDREMEGLKVQRVVRRVRGRVERAWGFVVERKGRWGGVLRSRLEGFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFL5</accession>
    <name>A0A9P4UFL5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_428313</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFL5"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="71"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
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            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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        </location>
    </feature>
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            <begin position="190"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2448205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="243" mass="28136" checksum="4A6661BB4B8C9979" modified="2023-09-13" version="1">MDGIASAVVLPDQDDDSPPPAATSPTGTKRRQSSISEQDAKRARLNDHESPSNRRGSVSSAKAAAVAPKGRERGRERRLFGAALGALSQNSATAGQKRRLEIEKRQRAQRKLEEEESEHRKQERQAKRKEQRWREHRRFEKDALRIRHDNLLAVAHFLQTRTEPRLYYKPWETTPEEDDRIRDQIAEAHETIRREREDSEAAQRRHAERKRDATHDVHMDGDAEDTRYARNKTAILHKPARPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG50</accession>
    <name>A0A9P4UG50_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2450724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="90" mass="9860" checksum="2638958B647DC7F5" modified="2023-09-13" version="1">MYTVSPMPRCCPCPNASGIPASASTLMMLALYRSARHGTHASRRLSRRAGRLEMLFTPIFGASATLFGGFAEAQWPGGVRLRTEVRYLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGW7</accession>
    <name>A0A9P4UGW7_9PLEO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">P171DRAFT_8320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4152802at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="889" mass="98946" checksum="90E6AB7B47B730E1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHM0</accession>
    <name>A0A9P4UHM0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_480493</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHM0"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051254">
        <property type="term" value="P:positive regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000257">
        <property type="entry name" value="CCR4-NOT core complex subunit Not4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CNOT4_RRM"/>
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        <property type="entry name" value="Mot2"/>
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    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="16">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="725"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2449407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="823" mass="88946" checksum="E8A5D0C4B349AA46" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHU1</accession>
    <name>A0A9P4UHU1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phox-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_428044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2449918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="314"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2449918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41227" checksum="E0C21FB19F89B2BE" modified="2023-09-13" version="1">MAPLRLSIPTTHTESDGGKEFTTYEIRIEHPFPRASTSLRKRYSDFAALDSTLRSQVGATPAPLPAKSWLGGFLGLGSTLGSPEQIEKRRQALEQYLQAIETGEDGRWRVTPAYREFLGLGSEKDKKAASLPGAQFGKDRVRDSTDWLDKYQEVKSNLQDARRWLTSREQATAATAQHEAGANAKKGLVRAGTLLSALEEGLNRLGSGGDGWGGDKLGDGEIRRRRDLIGTSRKERDGLESVLNTMAVKAAASGSTSSAPSTNSAAATNEQKAGLFSRANQGASGRSGRVLGAPAKETERTRELDNEGVLQLQEQIIAEQDQDLVDLTTVVRRMKEMGVQINDELQYQNELLNQFGDDVERVDGKMKIAKKRIAKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHZ9</accession>
    <name>A0A9P4UHZ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_467820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHZ9"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF32">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2451176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61802" checksum="5C85EB2C21D96F4D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI37</accession>
    <name>A0A9P4UI37_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_349353</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UI37"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="360"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="509"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="810"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="946"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2450845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="967" mass="107065" checksum="7DDBD9923C95581D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ56</accession>
    <name>A0A9P4UJ56_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_478359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ56"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="379" mass="42387" checksum="F9E95B06FFC7CA97" modified="2023-09-13" version="1">MQYRHSHLIDPSSYPTQGLCTGIPLRCHRNSDIDEHGTIRLRSDWQTHVGPLPQTTHGGLGPHYNFTAVTIPECRPDRLEIVAYAMEFAFLHDDLIDADETGNGVALYEGIMRDIGVRSRGGNPGGSVTGEGRLLRGIIEEMARIDAGRTREVLGYWKRGVSLPRDRTRFGSFEEYLDFRLVDSGAFLLTGLMTFGMALTIPPEEKDECVNLTRCVWLAAFLTNDVQSWEKEREEYKTLIAASDGEDTPHMVNGVWVLMQQDGVDVEEAIKRVLQKVKGFVADVVRTVEDVRSREDLSEDSRCFVEAAQYMVSGNLVWGIDSPRYHADRTLNALQVARMESTVCTWPHHVAPVIKDPNLLPTPLEDGARVGGGEYVESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJN6</accession>
    <name>A0A9P4UJN6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Poly A polymerase C-terminal region-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_468058</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJN6"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="12">
        <location>
            <begin position="145"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="13">
        <location>
            <begin position="323"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="CCA-adding enzyme C-terminal" evidence="14">
        <location>
            <begin position="529"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2451507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="976" mass="110216" checksum="605BBB890379B749" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4D0</accession>
    <name>A0A9P4P4D0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_458797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4D0"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2438129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="524" mass="57598" checksum="B3D3BC0FFAFF9DB2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4G7</accession>
    <name>A0A9P4P4G7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_437872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001517">
        <property type="protein sequence ID" value="KAF2437266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4G7"/>
    <dbReference type="OrthoDB" id="5423564at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="436" mass="50681" checksum="73C270023F48C31F" modified="2023-09-13" version="1">MEPDISLWLLADDPWNTDSLISWEDSNDFDPDDDWWGGCSCCAMLTRSFYVADQQADDLFAADFDNESYMNAAGRTTMHPYRDLRSASYARKRSSKKAKSRPRTQSVGGRKWEHAQCRRENKRKKRDTLRYEIYENQRRDRVCWCSPGKQKNLDIVVWDVNLEEEFDQELVAEWSHYEKFHKNAGEFESPEPYKETDEAFSVWAQRRIAEMRAVKESRMQTQVAPRQQPMVYKTNHYRPMRIGVDIFSYNIYCGSPLTTTQPTNAYDAYGHTLLRAALTPSRWARKRTRFDPKISLFPRIYNYSWFGEYTWRWHRNASGCWQIGYGECDGCAIPFPCSNTGGYLSNFDKCYCEEFEGEVAPEEQQRCSLVEWVGAEGRRLIRADEARAQANGHTRDCDNDFAGDSDSEWSFVDEYCGVRSCSSVASSIELSDGTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4W0</accession>
    <name>A0A9P4P4W0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_425565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001517">
        <property type="protein sequence ID" value="KAF2437292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4W0"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="5">
        <location>
            <begin position="28"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="813"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="853"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="902"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="942"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2437292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="994" mass="108643" checksum="6F9249B42D0AEF05" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5D1</accession>
    <name>A0A9P4P5D1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_437671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5D1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="81" mass="8717" checksum="ABB26A03F7C82764" modified="2023-09-13" version="1">MAHHLTGLGPSILLCSSRSVYQEHDGPLDDDDDDVLTQASLSQVHHIFCAGSKSSNATYLASHPSCTVLPLVTTQIERPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5E8</accession>
    <name>A0A9P4P5E8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_490753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5E8"/>
    <dbReference type="OrthoDB" id="5431013at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52763" checksum="DC0AAC6EE416B6CA" modified="2023-09-13" version="1">MIDPFSVAGLLASIIQIADALTRLSLEFERCLHTVRHAPQEVKSFHRDLSNFSASLHWFYEISESCLRDLEQSPKRKARRRHISGVIKECEVVEEGFHALLSRFIGKSTQLPGISSPVDRLRWYFRKPSVVGLKLSLESAKSTVELFMLLYICEDLQKKIQALQEARVEIPDDLKRRFDSLERQVMQQVNTTEDNYKRLTEHLERMPYSYHVLIPGMQSILVENRALERNATRSLRKENRKVWQGLSSARQPQTSQRRNPSPGPMSSVPGPRTPRPSPPAPNGVRVISTETPDPALRVSKELPKYFQSANPQPSVRPRGVEAVETSTTAQIDPIPSITSKRRSPITRSPKVPPINTNGSTIHKNAKETPESFVQRRPEASGSFIPSSHRQAYIVRSSSSSPKKGSPPVDRDSPASHSSEGNKQQQGIVKTEVEHIEGGKRSSIAGASPYRALPPFLDEDWKGVRRRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6M6</accession>
    <name>A0A9P4P6M6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_437835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6M6"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2437456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="614" mass="66996" checksum="9BF8C85E0C0E4A4B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7K5</accession>
    <name>A0A9P4P7K5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_114172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7K5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040481707" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="13929" checksum="A4EC54EA0E5B1A17" modified="2023-09-13" version="1">MAGRQVLLAYLTLLSTHNASFCITFGRQSVHVCLSLYGTLLCSSSQQSENHQSPSSTFRPQTKLMPTPPSVATSKNTRATAFPICDIDSIASQWKCAKRMHVLLHGSSGAHQHGKTSGVGRLRCLTGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8M8</accession>
    <name>A0A9P4P8M8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_491171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8M8"/>
    <dbReference type="OrthoDB" id="3791545at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040404657" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="82" mass="9571" checksum="560F6EA9267150C6" modified="2023-09-13" version="1">MPQALLLCLVSSLASIFVMVQQQAYGRYYSRDGLLKYLKSIFGENRTFKIKEVSDACFTFEAPRELTNQQWKDAKDPKWRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8S9</accession>
    <name>A0A9P4P8S9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA 3'-terminal phosphate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_466748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8S9"/>
    <dbReference type="OrthoDB" id="25029at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.20:FF:000013">
        <property type="entry name" value="TatD related DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="320"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="409" mass="44556" checksum="60E1859D0423696F" modified="2023-09-13" version="1">MAMPIHLEGTTLEGGGQLLRLATCLSALTSAPITITNIRAKRSGGGGLKAQHLTSVQWLGNASNARLSGVGLKSKEITFTPQSRTVSRLEWSNEGDVHIKQSTPGSVNLVLQAVLPYMLFANVGSADVEVGKEIRVKITGGTNVSNSPSCDYIEQVLAPMLSLIGIPPIKTQIHSRGWSQGGARLGSVTYSITPLSKPLPAFQLCDRGDVKSIRATIIAPKDAELRFRDELDVMFERREENIFRNTQPDVQVTFEDSMHEKRYYLLLVATTTTGVRLGRDWLYDHAVRAGKVDTVISNVVKKVSEDLIEEVDHAGCVDEYMRDQLVVFQALAVGKSNVYGGKRKEVLLEPSLHAKTAHWVAKEIIDVDFDNDGGCEGVGFGADQNYNTAESVVEQNLAHGLEKLEVAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P914</accession>
    <name>A0A9P4P914_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_457597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P914"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001138">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="474" mass="51200" checksum="93C769C0FE410F0B" modified="2023-09-13" version="1">MGHAPSSKASKHATCPRLRMIACLFSVYLNNLLGRRLSLIVTGFVSIVGVLIELTSSAGGGPARFGQFVAGKVIASIAMGLAANIVPIYLSETSAGERRGFAVTSYQNIMILGVILASGVVYASSTMATKAAYWIPIGMQLIAPSIMILGSPFLPESPRWLVWKGRNEEAKAAAQKLFSTPKNDFDAAEYVNAIEIALDSDRASGLESSWGDLFRGPDLRRLLIAVGIQSLQQAQGSSYMNNYVVSFLQSTGVKNVFPVIMGLYTLYYFAILTGHFLPDMVGRRPILMSTGAFCATCLITVSALVVAYSNPPEAAQKASIALIFLWQIGFGIQSPLIWIVTAESAPTRNREKVQAIAVFFGFGVSLLIASVSPYMQDADYGNLGGKIGFIWGAFSVVTVFWVFFMVPEMRGFTIEQLDFLFNTRIPTRKFAGYSFAVTEGEAVFDSTGDVQEELGKDDAKASVVATHKAVKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9A4</accession>
    <name>A0A9P4P9A4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_477166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9A4"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="40"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="473" mass="53284" checksum="DF5C0E133F633877" modified="2023-09-13" version="1">MTAVPHKPALHPLTSEDRGALIIIIAYSWICITVLAAVIRFGLAWTNRLHLKKDDGTFALGVVLAVASSVCFHIASNNGLGKRMAKVPLYDLDVYYKTTYTGDILGLAAQYWAKVSFLQLCERVAPRKERHYNIIFGLITFWGVFSVLAIAFQCGLPDPWVFKPDDCPTAGAMYYPVIIMNIITDLILGTWILPTLWKLLMDQDRRILVVMLFGSRIIVACVAAAQLSSVARHILDPDVTYQSFGRVLWALCVTHLSVLQATIPRTKRFIAALNMRTHATVRLTAFELQLPTNPTTFTVPGKDMDDTFSSSEATASRPEEAHTRSRSWTLKRSDSDRRSSSHSLPRSMQSERPLVPLQLTPSTELGFTTEIIAEPDPAAKDAGRTSKRYDSMDWKKYIRRSRNEDDMALSSMFSWKSRTSMARERIVQTKEVTQKVELVHQPKESRWNFRRQSERSKRQSVAGQGEGQGQGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9G8</accession>
    <name>A0A9P4P9G8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9G8"/>
    <dbReference type="OrthoDB" id="5366531at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="103065" checksum="8FB3F8CAA318C5BF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9K1</accession>
    <name>A0A9P4P9K1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_397269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9K1"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040201813" evidence="1">
        <location>
            <begin position="27"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="127"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="440" mass="47894" checksum="F1EED67B2986BECD" modified="2023-09-13" version="1">MKLHPHPFSALFSLFISLATTSPTEPDPIGQSPQIQDGLLVRAPTACPVVQDGLTSTTFPWTHAPTCLPLVLPVEPHGGRHGTYCVYTNAAFNDGRGISIVSSPESAAELAREVWETGVGRERAEGGLWEARDVEGKGVGLFAKRPIDSGETVILESPVVVVAREVLGSVSSSRRRVLLERAVGQLPERTREMVTALSRRGGESEVEDIVNVNAVGAKVWDGTSHLLVVPEAARINHACRPNAYYRFSDATLTLTVFALAPIPPGHELTFSYGFSLSPFSARTAALKETWGFTCTCPLCSSSPTNISLSDTRLADIAGLKTALPTSLEDIPQYIALIPRLVALLEEEGLYAELPMYEEILAYAWSAVGEEGRARAWAERAGVHWGIVAGKDSWEARRCEELAADVKGHYTWGTWEGDIWEAVGKGHPWDEREGDDHDHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA92</accession>
    <name>A0A9P4PA92_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_97951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA92"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
        <property type="entry name" value="HTH_put_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="202" mass="21536" checksum="1C78DF1E3B0286B0" modified="2023-09-13" version="1">MGSSASKGARAAGANLRKYPSRPAPGTTRAPAPAPPTQSGNVGPTVHPPPQASELRTQAIDPDARDPGLASRLSTIGAVQPNPHFSPSSTSSFDPRRNTSTTQPSDSYGMMDELPQSAFPDPGSNPALRILDARQRIQQEAEEELENVGRKSFRGRKYIDASTIALALMRRQRGEPDARIEQALGIKKGRLSALKEGMVTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAT7</accession>
    <name>A0A9P4PAT7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_457758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAT7"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="114" mass="12556" checksum="5A191B3B85D9A219" modified="2023-09-13" version="1">MTSTIGIPIKLLNEAAGHIVTLEITSGEVYRGKLIEAEDNMNVQLKDITVTARDGRVAHLEQVYIRGSHVRYFIVPDMLRNAPMFRSRGTRGRGVGLARGRATVNRARGARGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAW1</accession>
    <name>A0A9P4PAW1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_446488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAW1"/>
    <dbReference type="OrthoDB" id="4227097at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="173" mass="19272" checksum="F64AF48F1D61A810" modified="2023-09-13" version="1">MHKEFWDAPPDKRLALTFWSNRFTKPEPSTSQDFDSSASIEALKYLSILGKISPRIRALWGLMADICVCQERKVVIFCLSPLEQMIVAIVLRVVGLKAKALLSTFMALPSVFTSTNAIEPPVSSPVSTLLYAYPNPGVMCAPSQIYEQLRTMSLIKHSAASELSKYIESIIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB16</accession>
    <name>A0A9P4PB16_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_435928</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB16"/>
    <dbReference type="OrthoDB" id="2505961at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
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        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="351"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="116"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="202"/>
            <end position="350"/>
        </location>
    </feature>
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            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
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            <position position="368"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2440128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="411" mass="44621" checksum="4040FF46B568A8F9" modified="2023-09-13" version="1">MANPEDAATVLEQFIHDVANLPAEITHLFEEVQAKDELIQEARRTIATRDNSLQKFIKLNGSLVQNPKEEPYSKLIVEQYERSQILQEEKIGLVEKAAALLDRHVKRLDLKLKNLQDDGSISTDPQLPSLLRESPGNMVPPSSLSTTGANTPLQAVSGNQGPGGANLAHAAIARIANATNLSSRINPNLQNMTQQALLNQQRLTNQQSAAQATTRQEREMSASSDSKRRRPNLNTGPLPGPPSSLGRASSMGPGTPKPATPGSRAGSVGPSRSQKHPLMVKKAKPQQPLRKAALTAKSGSNKKRRKGGSRASPSTTADDESVASEAGTEDEEMSGMGNGEGDDEEDETDNRKYCTCQRVSFGDMVACDNDNCKHQWFHWECVGIKEEPVGDWLCPECSKLPPTKIKRAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBG1</accession>
    <name>A0A9P4PBG1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_117341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="84326" checksum="B88155FE3690F612" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCT6</accession>
    <name>A0A9P4PCT6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_47272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
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            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCT6"/>
    <dbReference type="OrthoDB" id="3945111at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="509" mass="55784" checksum="F91DB3F0569306F8" modified="2023-09-13" version="1">MDVPPETFPSSSASIRRDTMSTISSDKQPSPPSGSWPVTIHGNCARCGHYHKAAVVQIHLVEGMCEASDVVCDRCGQKWLTVGGLNSTQISLLSTVTTELDYGEINFRYTLLSMVRSTVSIASPTALANVPEDPSPTPSRKSSARCDRKLPDDSANAERGINRNYRTNASPVFNVEARPTLKNEPMARSSLPSLSKNGTPALKVIRRKLKNAFESEGSVPNTEMEIQRQSTSLEVVASASLGNERPSRPAKYDDGGPAKTTRQIIEDLKSVDKEAIRNMTPKQRDMWIRERITAFKQSKRRSALQCDCKRRHSTSSIGDYYSLPPHRSATTSTFQRYSLEQMGSQFDALPAGALFTHTGPLTISATRISEADTAVELPEGSSSPRSSLHAHSRSPRPASLFRSRLSWQQPRYARTQRDSMDSVLAGTARSSWRGVDRLSLASVAPQDISTGSDAPETSRSADPVMEEEVSTTSRRSGVPVPALLLRTTWLQWALTVTCTNYSISFKSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDX4</accession>
    <name>A0A9P4PDX4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lccl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_433716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDX4"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23057" checksum="62236AC8CF04B156" modified="2023-09-13" version="1">MAAPANKNIKDLNGKWSINKTHSDSTDPVLALQGIGWMTRKALGIATVTQHTKMYTKTPEDNTAAGDVIHIDIDQMVTGGLKGTSEHRALDWKYRSHSDWLFGEVQGRTRLTTLEAVRKEAQEAGGVTASDAEFVTQGFLAETEEGETIEGFVVNDGKKWTAWQIWGFATVNGERWLVRSFAVRRKDKDEVVRVRLCYEWVGELDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE13</accession>
    <name>A0A9P4PE13_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_433764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE13"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="275"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1147" mass="131359" checksum="C1C5673C9774B6AA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE94</accession>
    <name>A0A9P4PE94_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_433905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE94"/>
    <dbReference type="OrthoDB" id="10590663at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="123" mass="14088" checksum="0961A66D6E172C3B" modified="2023-09-13" version="1">MHRLQLENAQASREAEIAYNGLAAAYREMLSACDDYKAEVDTTQATVDEMEGRLQAVKARVDALKEQRNVFQQREKVLEEDLLHSKADRDAVLEKLVVALEQKKEALESQLEAWKMVDRLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE97</accession>
    <name>A0A9P4PE97_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_391993</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE97"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2442272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="421" mass="48361" checksum="4028AF49B7F3DCFA" modified="2023-09-13" version="1">MAEDFSEGRLETFVDTPQKELPGTKDAYVSYLVTTKSDFQSFQRPEFSVRRRFTDFVFLWKQLTKEYPQCAVPPLPDKHKMEYVRGDRFGPDFTQRRAHSLHRFLKRITLHPVLRRAMLLISFVESPDWNQHMKGRSSRAASGSDAGGGGFMDAVAESFVNTFTKVHKPDKRFIEVSERATKLTEDLSNVEKVVVRVARRQGDLDSDYNELATQCHKLQTLEPGVEGPLTSFAHSVQTNSQGFKDLRDKTDQNYLTSLRDMDAYVLALKQLLRAREAKQLDFEALSDLLARNASDRDSLASSHGTGMSASGFLRQKVEDFRGIDHEQARRNRVRKLEIDIERLTGEVENAKKATEAFDEHTVKEVADFERIKAFEFKDTMGDLADAHIEFFNNTVETWEAFLAQMRKEEDERKKAQEQDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF78</accession>
    <name>A0A9P4PF78_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_474677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF78"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="355" mass="39990" checksum="A14C3CC3A85895A9" modified="2023-09-13" version="1" fragment="single">MKTWLHVHGLRRQHSDAPLSTQNDSSSATKNAQPGQWLPSRALTDSAAKIAASKTASRMSIERYLQAPLEDEPASVPAINAALKDKSSPAWSKHNQPRRVLRQAHSRETSYDANSEGRRTFYTSASGQESTGTSFSIGHRSNHHQRSNLHLMMPQLPRLRTVSLMHGSVHSPEEPTTGKTLNSERTLTDQHETIPLGKSVDSAYRARIESELALIQEKARRLEEEVQRFDERKENEELLVPRITDERAHQQMALNPKLAWILGGDSTNTSGMERPMTSTSITVDTLSDMPSRPATSGRLTRPVLEKLLRRSKSSSVLLDESHWSSDRRRAVLVGRTSSKRPRFFCTFCQKRFHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFN9</accession>
    <name>A0A9P4PFN9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_27522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFN9"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="214" mass="24962" checksum="A48C60F3A557F31F" modified="2023-09-13" version="1">MCASIVDTLNQMSSKDDPIVVVKFFFDFRARDHQDACAFLSSMLVQIQKAKCEVLLKLSSLHGYHSKLSQPPSEVELLNALRIVLLEQNRVYTIIDGLDECRVHGRVIETLEEICKWQMPHHQSKLSANFYITNSCLLYLQYFDRMQQSNPTSYTHLPLYPYCISHWFHHYKFSNRPAELTVHSRGHRIYLRHRFLALSEPDVDQTGSSMEQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGE2</accession>
    <name>A0A9P4PGE2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGE2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="216" mass="23654" checksum="2554FE7EBFFCA526" modified="2023-09-13" version="1">MDTDASALLARQAGHEVTPGSTRKTAQSAANIRPCYGFGLAPWTAARARLKARTWAAWAASWVRINRHAAANTRPFPSRRYGRRQEHVQRDAEQHAPGKPIRGENIPSSATAENERICSSLATLRGCERGCQSHENSWPAAGAPMPPRTPAAGTIRLPLQSNRVGVVEEHNTKSKFPELASCVRSEAQPMVSAHTSKWAIVALPLFVPQIRLRKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHG0</accession>
    <name>A0A9P4PHG0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_289996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHG0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="174" mass="18608" checksum="7F6724CA8677CD93" modified="2023-09-13" version="1">MVPIHVGWEALASKWTVVRGGPEDQTSSPAHRRTHCTLYTVHCTPFTVHCRAVMLPALRIMSGSCPCGEMGAGRAGPMATGAVRCGGLSSRARKRMQHLAPSLQRPPSSSLFAATISMRPDHHHDQPLPACISHMAARPSTGPSAARAPTHTRSGRPSPVDALSRPSPYLRQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHK7</accession>
    <name>A0A9P4PHK7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_413320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHK7"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2445194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="389" mass="43329" checksum="1941021689E9CA74" modified="2023-09-13" version="1">MALDTFYHNKIESMKLEIIQGQAVLRRLEAQRNDYNSRVRLLREELGLLQQPGSYVGEVVKVMGTKKVLVKVHPEGKYVVDISDSVDIAKLTVGKRVTLLSDSYKLEKMLPSSVDPLVSLMMVEKVPDSTYDMIGGLDQQIKEIKEVIELGLQHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHADCKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFEPTKNIKIIMATNRLDILDPALLRPGRIDRKIEFPPPSVEARADILRIHSRSMNLTRGINLTKIAEKMNGCSGAELKGVCTEAGMFALRERRVHVTQEDFDLATAKVLNKHDDKATSLSKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHV4</accession>
    <name>A0A9P4PHV4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_360624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHV4"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040353719" evidence="2">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="237" mass="24934" checksum="0EEF3530029587DF" modified="2023-09-13" version="1">MVNWVFGAALAGVASATVAPGFPVKGSPDLNVTWANNNVSPTGELLSLADTAEAPSQISAPVWTQGGHAVLMLVDLDVPRNNTRVQLLHWLTANVTMPSTDTQTLKLEDPSKDLAPYRRPSPPLHDIPHKYTLLLFAQPENFTVPARFKSLLQSRVGWDTAAFVNATGLGNALAADWIRVQNTGNETLNATASSSATSTASSAPTSTSTDYTGMAGAVEPRAWMGAALVAGLMAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI67</accession>
    <name>A0A9P4PI67_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_266622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI67"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="246" mass="27357" checksum="B9E4280F64059AB4" modified="2023-09-13" version="1">MRMRRGRATQAALYRRQDKSWTRMISREYVEGRLAEKNHRLYGWPIPSHLTATVAALASEPAPAPAALSPPAAPSARTKSEDPDDEKSRRIAAGMGKLEEIDLGPASTSRAEAAWKKLQGGSGQQEEAAKVRLGRDGKPRRQPKRRNSEDIRRDAMVEAVLREAKLDYFDSAPPDPSTSTTKTNNDEALVEQFRQEFLDSIQERQQRKPAAPVRGEKEAPKGPKLGGSRSARAKMHALEEVAKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIY9</accession>
    <name>A0A9P4PIY9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_463890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIY9"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040183487" description="MICOS complex subunit" evidence="3">
        <location>
            <begin position="28"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="245" mass="26630" checksum="228110E3E35AF792" modified="2023-09-13" version="1">MAFRPLLRQRFAPVWAVAVAAAPISLSSPPVDDALTDAALNRKPIYDEAPLDTTAPSPTQPAAPSTPASDAVYRPTPTDRLAVQIGKARLAMYQQAVRAEDGVNNALTETLRLEHSFTSTIRSLAPPRESAERVFPGVLYVLVASMAGSIITRNRNILLRATVPAAIGLGAAYAVLPLTMKNVGDLAWKYEERYPVLADAHLRTKERVTSLWETGKAHSAMSVGMIQDKVAETRSNMEDWVKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ67</accession>
    <name>A0A9P4PJ67_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_522314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ67"/>
    <dbReference type="OrthoDB" id="3945961at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="182"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="704" mass="80251" checksum="F613761978B0071F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJG4</accession>
    <name>A0A9P4PJG4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding module family 50 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_289894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJG4"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="257" mass="28401" checksum="24C8ED342AE89D78" modified="2023-09-13" version="1">MELCCYPRAGEYLLFQCGRERDRITLTVCSVLQVLPGDFICIGPPGGSYVAELVPGATGGKPVYTTTALPAKETPPGTIKNCGHYYDVVSGDYCQMIAMNFSITFDILRTMNPQLDADCSNLWANASYCVATVRGSTLTPVSVLVQSRDCYLTLSRISDNFIIDVGVFGNCDQASIVVDIREVNVIRYGVLIGQAVFQCDTQGDNRASGANAIWSIQSMLSMVYSRRWGLLLPYIYQVRDYVRPIESVEYSARCRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJI6</accession>
    <name>A0A9P4PJI6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_255698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJI6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="134" mass="14892" checksum="A28E1CF36211D3BB" modified="2023-09-13" version="1">MQGERVGRGRAAMQRGIFGTAKSGHLPPTDLRRCRHAEDRPGCWDHLLFPLTMHRIAARACATPERERPCLSSLCIAVPHASIVGVARTIAAHPAMPCKKSKPFRHGATRRPRPLEPQLHPPARVFRHVPSQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJJ4</accession>
    <name>A0A9P4PJJ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Golgi apparatus membrane protein TVP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_290766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJJ4"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2445172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15454" checksum="9FEB7BE4E260A4E1" modified="2023-09-13" version="1">MVSLDSFIVLSQASTGVICIFLCFALGISNLFNAHWVIAFSIVCLVYAPVILFLEVPLLLRICPTSPKFDVFIRKFETNFLRAGLYAAMSAIQWASIAARVTSLIAAAVVLLFAAVFYALAGLKGQAFQGSKTLGGQGVAQMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKB3</accession>
    <name>A0A9P4PKB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_473559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKB3"/>
    <dbReference type="OrthoDB" id="3049701at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1870">
        <property type="entry name" value="Fic/DOC protein, Fido domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006440">
        <property type="entry name" value="Doc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053737">
        <property type="entry name" value="Type_II_TA_Toxin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01550">
        <property type="entry name" value="DOC_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426">
        <property type="entry name" value="HOMOLOGY TO DEATH-ON-CURING PROTEIN OF PHAGE P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426:SF1">
        <property type="entry name" value="HOMOLOGY TO DEATH-ON-CURING PROTEIN OF PHAGE P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="153" mass="17244" checksum="5ACB3A443AAA0565" modified="2023-09-13" version="1">MASNIPKFRFLTAAQVRRLHGTLIANAQPTQPALLESAVQSPLNIKYYNNEQNLFQLAASLPEKIMKNHAYQDGNKRTALVAADMFLKINGYKLQETPLQTGNVSQDLENAHVAVCTNAWTAEELGRFYEQSAKAIEEWTPEILAYRNEATEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKS0</accession>
    <name>A0A9P4PKS0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_484753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKS0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="189" mass="20972" checksum="F693DADFAFF09704" modified="2023-09-13" version="1">MAADTATNTISTLNETISTLESKIEELQAAVTELEHNLATEKSKADAAARASDNMTRRLRDAEATPEAHRLKAEAAFKTGTELQVVVTELETQASKANDKFSKLRAEAHDKILKLRNHIKSSELDAAHQKAKTQERDSSEKFSKLRDEANDKLSKLRDDIKSIREEAKAQASSLEAEKSTLSTRIDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL45</accession>
    <name>A0A9P4PL45_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_284734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL45"/>
    <dbReference type="OrthoDB" id="5389823at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="228" mass="25975" checksum="B590ECB4B79E25B1" modified="2023-09-13" version="1">MSFNFLEPSRLPFRPRPPQMSNLPRPPMPIPMGEQLHRAMPGSPFVDMDPRDPRVMSAPFDSRLGMEAPDYFSALGSPMGIGAFGPCNQRNSYPPGFEPETMMSGPGQYIDELVRRTNLMVQFVNSQIRPGARYCQLQPKMCHDAKFPPEFRIPKTVDEVRAMDPSSVDRVLRAYNLPTDLRSFRTMTQDTINHRTAHQAKLCTLFDFLGATQISERQRNKRNNGPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLQ6</accession>
    <name>A0A9P4PLQ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-dehydroshikimate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_291684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLQ6"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="27"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="366" mass="41380" checksum="DF138A7A6CBD4D96" modified="2023-09-13" version="1">MVCRPGISSMSLGRCYAGHSMEHKLSMAAKNGLQGIELFYEDLADLAQPPTPSNLLSAAAHVRTLCTSLGLEIICLQPFMHYEGLLDRSKHAKRIEEMHLWIQLAQFLDTDLIQVPSSFLAAEEISDDVEFIVSDLRELADIGLQHSPPIRFAYESLCWGTYVDKWELCWDIVRRVDRPNFGICLDSFNILGRIYADPTSPTGCNAGAEEEVQASVRRLVEQIGPHKDKIFFFQMVDAERLEQPLLPGHAFYNAAQPARMSWSRNCRLFYGETEHGAYLPVRDVAHAIIKEIGFEGWVSMELFNRAMERKDEGVVEELASRAGESWRRMVVDLGMEAEAEEVRTKSIVRTDSGTDIVKREVDVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMN2</accession>
    <name>A0A9P4PMN2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_235059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMN2"/>
    <dbReference type="OrthoDB" id="5360701at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="431" mass="47532" checksum="C9E997552FC1D4C8" modified="2023-09-13" version="1">MKPGSLPLRAPSRPVCQLCDYLLQQPASRRSFLAAASTFKPPALRRQTAKQHAILPRAPMRSAATVRTPPAQASGAENHQQWAERVAVLKKKLAEVERHIAWINSSNKVEPESATLAALEALEAIARQAIAIRSGKPPPPKIEIKQSSAGAILSMGREDDAPVAQPPTSRAPSLNELPSPQYISRLAMDLLKHPNVFISSEILGAYIRLQRLIGCPRAIPEILYLYANKPVPQLGSSPPKFSKPSPKAVKQAIPVDLAQQALGAAIEAKDMPLALDIVEVTYCTPAWRRHRMLTKMGLPGVIAAITPLAIYMLAQEASVYSGYIEPRTFKLYAFAGISTYVLCTGTLGFVALTTHNDHHTRVVWRPGTPLLDRYMREDERAALDRIACAWGFKEEWRRGDEEGEEWEGLREWVSLRGMVLDKPDLMPGMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMP5</accession>
    <name>A0A9P4PMP5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMP5"/>
    <dbReference type="OrthoDB" id="10590145at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040505309" evidence="1">
        <location>
            <begin position="16"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="168" mass="16726" checksum="CE2EB082148661FF" modified="2023-09-13" version="1">MKSFAIAAFAAVAVAFPQYEVAPPAYNTTSVETPAYSTPAIPSYAASSSSAEYSYSATTVECSGPTEVPVGPSYTFTYTGTETTTLTFSYPVSAPAGEYTPAPVVPSVPSYPTANGTLPAPVGTAPPATGTGSYTVPSPSAPATEFPGAAGKTGLSMIAVVGAIAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNL2</accession>
    <name>A0A9P4PNL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Linear gramicidin synthetase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_482249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="538"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2447511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1286" mass="139755" checksum="48A522F2E4B65600" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNW9</accession>
    <name>A0A9P4PNW9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Het-C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_518629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNW9"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040255054" evidence="2">
        <location>
            <begin position="26"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="806" mass="85533" checksum="AB67BF5E12EEB037" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPB8</accession>
    <name>A0A9P4PPB8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_354275</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 15"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPB8"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="161"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2447916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="462" mass="49383" checksum="998CE5815AFEA849" modified="2023-09-13" version="1">MSSSLALQPQAVSAPGKVFVAGGYLVLDPKYTALVFGLDARIHVGIEPIQTKSGVILSEIIVRSPQFRDAAWEYGYRLTEHHGGIAVTQLRASHTSSLNKNPFIETALTYALTYISTLESTPIPPSSVSILADQAYYSNPGTPLSSNSRFLNFDVTLADAHKTGLGSSAALVTAFTAAILSYYLPRDVFDVDSEHGKKVLHNLSQASHCAAQGKVGSGFDIASAVYGSCLYRRFSPSLLSSLPAPGSASFAPQLRALIEGDTWDVEIAKAKVKMPQGLRLLMCDVDCGSQTPGMVRTVLKWREENPELANRIWGELQSGNEAFAAELTRLATEDGRGAGAERFAKLKGLFKANRALIREMSKASGVPIEPPQQTALLDACSAVSGVVGGVVPGAGGYDAIVLLLEDKEGVIGELRKVVQGWKVDGESEDGVTIGKVGILGVREDMVGVKREDIDIYREWIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPF6</accession>
    <name>A0A9P4PPF6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_242533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPF6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="226" mass="23986" checksum="0A35496CBC3E3BC3" modified="2023-09-13" version="1">MAHLKLPVVSSRRERLRNPAGEKPRMTVTDDGYTAGDGSSTLEGRTRLDALGLSPAHAGGSQQMSSNKCFAVSPDLVEGASLRSPGAGLCTSPRVIAYLRRTLCGCLLPTAHRDTQRTAQARQQVETSHKSTPYTTVCRAAQQGVSARQMDGHWAVGVWRAVLTYATGAPGVDTFGLGRAVCLLGCRSRMRRVGPCARAASPGCARCSLTLRAASFPETPPASSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPS1</accession>
    <name>A0A9P4PPS1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_518961</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPS1"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000005">
        <property type="entry name" value="Exosome complex exonuclease dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="17">
        <location>
            <begin position="87"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="18">
        <location>
            <begin position="523"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2447947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="990" mass="111666" checksum="E936FB7D32BF5CEE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQV2</accession>
    <name>A0A9P4PQV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_508684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQV2"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF124">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="263" mass="27720" checksum="B3E1ECBEBD7155AD" modified="2023-09-13" version="1">MTGPRLLNKVAIVTGSSQGIGREICNQFYEEGALLVCSDLRPIGQGEEVATHEFIVQKGGKAIFVQTDVSKAEDWSALISKTVEEYGRLDILVNNAGICTEANNPQPIDEVDEDAFDAHLRINTRGVFLGCKYAVRQFKKQDLHPSGVRGWIVNFASMVANIGMAGLSGYTASKGAVAALTKTVALDVAKQGIVANSICPGSMLDNALGGALSSARDAVLAALPRGRFGEAKDHARAAVYLASDDAAWVTGINLNVDGGLTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR28</accession>
    <name>A0A9P4PR28_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_353969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR28"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2447449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="344" mass="37420" checksum="E0803F3B3094E9AC" modified="2023-09-13" version="1">MPRSDDQSEQGGLEFHKETPPEEPAFTLSPLRTYTSPQVLHTSTSPPCIRDPPTTTHLLTPPQAIGQIRSTASMTHNLTQCTTLIQRASALGAAALFLPEAADYIASSADETLSLARPLTTSPFVLGLRAAAKKHNLPLSVGIHEPTPSGAKVLNTLLWIDASGTIAHRYTKLHLFDVAIADGPTLQESASVERGVRIEDPVATPLGKVGMLICFDLRFPEVGVALRNRGAQVLVYPSAFTVPTGKAHWEALLRARAIETQSYVVAAAQVGFHNEEETRRSYGHSMVVDPWGRVVAELGGEEDEKGRGLDVGEIALAEIDLEYLEKIRREVPLLRRTDVYPELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR84</accession>
    <name>A0A9P4PR84_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_429403</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR84"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2447798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="183" mass="20969" checksum="CDDC2ED59A2809FB" modified="2023-09-13" version="1">MGLTFSKLFDKLWGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRVVEAREELQRMLNEDELRDAMLLVFANKQDLPNAMNAAEITDKLGLHSLRQRAWYIQSTCATSGDGLYEGLEWLSNSLRKAGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRY9</accession>
    <name>A0A9P4PRY9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_404462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRY9"/>
    <dbReference type="OrthoDB" id="2153847at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040345921" evidence="1">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="105" mass="10605" checksum="D773BEF5E2BB483B" modified="2023-09-13" version="1">MKFTTAVVLFSAVALTNAIAIRQSNAQTFTGALGGIAATPVEDSGDAKRPFSVKGGTFVNLSAAVQRSCDQQFNACANLANGGSQDVAFADCTAQKNQCDAAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS46</accession>
    <name>A0A9P4PS46_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_427443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS46"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2449192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="409" mass="45052" checksum="0260758C9B300506" modified="2023-09-13" version="1">MVYDLLCIGFGPAQLATAIANHESRKPANVLFVERKPTFSWHSPQLTRTRMESPFIYDLATTRNPRSAFSYTNYLFVRDRLVEFTNSDRLNPLRLEFEDYLSWAAGHFKDNVRYGSEVVGVAPEKCDGPVRRWNVAIRDAKGQTQVVQARSIVGPSPSGKHDQKPLSLTSVDFLAGQRIISVDDYKSRRNDLRGNNEPRLNIAVVGSGEQTIEILDDLLTCPRLGNITVVTENESLAPLRILDGEQEPPQPRLCSIWAKPSCEQKSPITGSSELVQDIYARAYEKQVASKGEYTLRVVVGSRDAGGACSSANVIIAEQAQRSAFANNGLFHGLDALVLGCRQKGDSLEEVQFKRGAVAESCKVWMLSAHSEGGRSLAKDIAVRAGEVVKALATTEEGRERDGVTIAARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PST7</accession>
    <name>A0A9P4PST7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_210147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PST7"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="109"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="406" mass="45324" checksum="72BFF00FD30C646F" modified="2023-09-13" version="1">MAFKFGLKNKLSNGPNKPSLGKPSLGKKKPLFDEDDEPKPKPKPKAADGAEEIAEFNFEDTLAAPSKAEKPAPKPKSKPKTLEPPKRKALAKEDDPTRVANLASAKESERRAKEAQELDASIYDYDAAYEAIHARQLAKKAAEREEAADQTPKYMEALFESAEQRKKDQLRARDKILQRERETEGDEFADKEKFVTGAYKLQQEEARKAEEEENKRQEEEEEQKRKYGMQNFHKLRLMEEEKRHQEAMEAAAELAKSGVKLEEQPKEKTDAEIAVEARAQGKDITVNDEGQVTDKRQLLSAGLNIIAKPKKPTTTGPTAAKPAAPNTGFQGRNAARNDIRARHTQMVAQQIEQAAKRKADEEAEEAGKLQHASKSQKTATDISSAKERYLQRKREAAAAKAAAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSU5</accession>
    <name>A0A9P4PSU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_353162</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSU5"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF283">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040255056" evidence="12">
        <location>
            <begin position="29"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2448723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="369" mass="39803" checksum="C3FEFFC967FC7BE6" modified="2023-09-13" version="1">MFVASIGEWVGTTLFLFFAFAGTQVANAHSKTSDESTTTNATAGFSPIVMLYISVSFGFSLMVNVWIFFRISGGLFNPAVTLALWATGAVGATRAVCLFVSQIIGSITASALVLAMFPTPLNVRTTLSEGTSLAQGVFIEALMTAELVFTILMLAKEKHKSTFIAPVGIGLALFVAELVGVYYTGGSLNPARSLGPCIVTNKYDTEHWIYWVGPGIGSLLAIGFYKFIKMLEYEMANPGQDGDDDNDPTKNPNHEVREKQRLTTAKVLQSLGYPNLGDGQGQASLDTMRQAEEGGFYGSRTPSVLDMADEPERRMNPGLALSTVASMSDMQSPIRSDMHSPVRNDMHSPAYTPSERTSSDKKTNSGVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSY7</accession>
    <name>A0A9P4PSY7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_481338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSY7"/>
    <dbReference type="OrthoDB" id="3794059at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="196" mass="21768" checksum="39CD0CBC7E37E370" modified="2023-09-13" version="1">MAFQPQLRVVSTSTAAQNCTTTPCHAAQIHHRILSQVKSILFNGPTSPGEAWIYEYAKCIRGDLDARNMKFQVSILQKGFEASSLVFPPAPGFLHDVCQLIAMLPLKVGTVIERKLVIDLLLEAARQCNMAWWDSTREVSAVVFGVVHACMIYRHLEAEKQGDAELGMIMGKMDLEADHIETVMQLAESLEEGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT87</accession>
    <name>A0A9P4PT87_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT87"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="126" mass="13653" checksum="E83545B056BB53C5" modified="2023-09-13" version="1">MLDHFTFTVPPAQYDAIVTWYLAALAPLNYTKQFDFPGHACGLGPDKAQAVFWIGAGEGATARGFHLAFKAEHHETVDRFHAAALKAGGEDNGGPGLRERYGPHYYGAFVLDPLGNNIEVVDKAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTB4</accession>
    <name>A0A9P4PTB4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_405342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTB4"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2449807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="783" mass="87797" checksum="8C391F6DC2354209" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUJ7</accession>
    <name>A0A9P4PUJ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_351433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUJ7"/>
    <dbReference type="OrthoDB" id="5426978at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="767" mass="83934" checksum="C723878BA135ED0D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUX4</accession>
    <name>A0A9P4PUX4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_404333</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="11"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUX4"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="18">
        <location>
            <begin position="28"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2449246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="181" mass="20581" checksum="15BF86231043D7EA" modified="2023-09-13" version="1">MMKIWSMKKQQKDAEVAAAASGKKKFSAADLRVIKDLEHLSLSDTMELKRELDNYKNFTLAINPDEGMYKGGHFEFAFEIKPTFPYDAPKVRCTQKIYHPNIDLEGNVCLNILREDWKPVLNLNAIFVGVQYLFLEPNASDPLNKEAAEDLKHNREGFKRNVRAAMGGGTVKGESFDRVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUY6</accession>
    <name>A0A9P4PUY6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_427007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUY6"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="428"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="633" mass="70188" checksum="AF7B0EAC20548500" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV10</accession>
    <name>A0A9P4PV10_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CSN12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_427064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV10"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000366">
        <property type="entry name" value="COP9 signalosome complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="250"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2450752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="457" mass="52201" checksum="6BF1AAF5BBD2FFF6" modified="2023-09-13" version="1">MSMEAALTGFQQAYYKHDALDLANCLKPTPVDRLYDFWRSTNEVRVEHNVKHAITYGLGGIERAEAQGWIDVFVHFWRASDKIIKADQAQNQGRLSERHAVEVYEAWKDLVQTFQKYIGNGTLPHWIIFTLYFVANDLRKFAIKADTQLAKAKPVTFSAGLSDDVVATTPKNQKLEEAARVFSRIFALCMSDRNPNLSESRKWAVYCIANLQFKTYFKLKTITLCKNLIKSIEAQADMPPWNLYPKAHRVTYMYYCGVIAFLQEDYNKAETALFNSWAYCYKGSTKNRELILTYLIPCRLITKSEIPSAQILQEFPHLQTLFGDLVSSIKRGDLAGFDKAFAEGEPEFVRRRVFLTLERSRDIALRNLLRKVFLAAGYEDLKEGQTEKDRMRRTRIPLAHFATALRMGSGGGQTVDDEEVECLLANMIYKGLMKGYISREHAMVVLNKKGAFPGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVI8</accession>
    <name>A0A9P4PVI8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_428113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVI8"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2450003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="531" mass="56620" checksum="B1CF6FB57D29FA0F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWR3</accession>
    <name>A0A9P4PWR3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_438547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWR3"/>
    <dbReference type="OrthoDB" id="4588275at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="499" mass="54173" checksum="54C8EB108DCBDF5A" modified="2023-09-13" version="1">MAVVTPTPTFAPTGVYVPPPSHSVTLFTPAPSCSPEKLWLVSTQLCDVNGGNQFNGRFPSWAECALTLAGDPHSPYRNIDCYPWNLEAEDGTHVFISECPVGYTTVWESQGRQDLYDTSTITQGGTIATSVEYRDIVAHSAVCCPDNALGGFHYNWDSKPDYIDYIQTADPNGNPEKVNLYVPPRCVANSICAVPPTVTLDVIFNSEVSDKKRRRQDTPPDNISPVGVVTRPWDANKNVVFAHSVEFGYTVFHGTYTCFENCYDYASYSYHNTDPNSPPSSIGPDDLETTADFKPEQTQCSASPTDSGPSETSPPDSPPVGTGGSGYSTPSTGHRYNATQTEGGYFAPSQPSGDYSTSPSKTDAGYEVSPSETNIPHYSPKPTIIETIVISTHTFGESAGWNATATGPGYSTTEGTGEPTPGAPEESETGAPLFPVVMMKNGNAVEETYLPLLCVFFVSADVSQQRQLYLTKNGFAYEYNFFLHHNDCPMSLSRLYRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX11</accession>
    <name>A0A9P4PX11_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_146665</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX11"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2450798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="96" mass="11080" checksum="9548041707E670E4" modified="2023-09-13" version="1">MASEKDLPIKQEAQIKSADMSDEMQQEAIEVAQSAMDQFSIEKDIAQYIKKEFDSRKGATWHCIVGRNFGSFVTHETKHFIYFYLGHCAILLFKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYQ6</accession>
    <name>A0A9P4PYQ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_3704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYQ6"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2451304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="239" mass="25903" checksum="A122D16006D5A4A0" modified="2023-09-13" version="1">MPYNNTPIAPSKEVSGQVSLPLARVQKIINADPERLHTSKNAAFAIALATELFIQHFATATHNVVKAETQKKPRRNVQYRDVASAVSKTDNLEFLVDVVPKTKLYKEVRERREKKKEEGEADGAGEEGAEKGNALERLMANGKKAAEAEKEKADGAVEAMDVDEEADKAEEAEETPAVEVEDSEPEEDEAAMQIEMEMRGPRTNGGAAVASPKAPVESPPAPTHRPTRSSGFTAINGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U3Z7</accession>
    <name>A0A9P4U3Z7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_449989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9368434at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1026"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1055"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1085"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1199"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1271"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1301"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1341"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1376"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="928"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2437404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1428" mass="156830" checksum="8BB8E3AF80952F17" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4N3</accession>
    <name>A0A9P4U4N3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD dependent epimerase/dehydratase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_458804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4N3"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2438139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="227" mass="23933" checksum="9FF816E6A0709A55" modified="2023-09-13" version="1">MASAPLTNPYAPQGSHILSTLLAHPSIASVSAYARRAPPNPTASPKLSHIPSTTPSDWPAAFPKQPLPSIFFSGLGTTRGAAGSVAAQRKIDVDLNVSLAQAAKDAGVECYVLISSGGANAASMMAYAQMKGELEEKVKALGFKHTVILRPGLIQGAREESRPAEAAVRSLAGWMRKISPRLTDFWVNEAEHIGKAAVVAGLKCVQGEREAGVWEIGQGEIEKLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5S3</accession>
    <name>A0A9P4U5S3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_372554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5S3"/>
    <dbReference type="OrthoDB" id="5407894at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="570" mass="61597" checksum="D7E83A95CECD63A8" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6A6</accession>
    <name>A0A9P4U6A6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-alpha--hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_421201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6A6"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF45">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="249" mass="26321" checksum="1A527560B25D97D6" modified="2023-09-13" version="1">MSLKDKVIVITGAASGMGLGTARLFASKGAKLSLADVQEKPLKDLEAELQASGAEIMATVVDVSNRKSVDDWISATVSKFGKLDGAANLAGVIGRQNNTAGVADLDDDDWDFIFNVNTKGLMFCLRAQAPVMNEGGSIVNAASILGLIGSARSMPYSASKHAVVGMTRSAAKELGARNIRVNCFCPGPIDTPMFRKSAEIRGNEMNTDFLALKRTGDQKEVPPLIEFLISDASSFITGVAMPIDGGWFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6I6</accession>
    <name>A0A9P4U6I6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_437232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6I6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="84" mass="9902" checksum="5D4AC4C973138CF3" modified="2023-09-13" version="1">MKRNIRSPHRKIINRRIYLPTKPRHHLHRPRRPPLPRNWNPSKHPRLAVRKPPCTSIPLTLIHMSKSLEIITYQGAIASKINPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7H7</accession>
    <name>A0A9P4U7H7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_434904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7H7"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2441229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="205" mass="22439" checksum="BE8174656CB6E5C0" modified="2023-09-13" version="1">MSSPFSINGGACVAMVGKDCVAIACDLRLGMQALTVSNNFPKIFQYGDVFLGLTGLATDVSTVSDLFRYKVNMYRLREERNISPQTMANLVSSSLYERRFGPYFVSPVIAGINQTTGKPFICGFDSIGCIDFAKDFIVSGTASDQLFGTCEGLWEPDLGPEDLFETCSQALLNAVDRDALSGWGAHVYIIEKDKVTKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7J5</accession>
    <name>A0A9P4U7J5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7J5"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="283" mass="31529" checksum="26BE8C6D6D72B18E" modified="2023-09-13" version="1">MSQIRFPTGLKMSDCLGGGLTGMVYLDETSNTVIKFPHEGDEPAINVERQIYERFQQHGGHEGLLQYYGTSEIGIKLEYTSLHNLRQYIQIHDEINAKHRLQWSQQITSALAFVHSMNVIHGDLTCHNISLDNSQNAKLFDFGGSSIDGSDPLIGVTASHRWPGNDDKSTQVDLFALGSTLYEIWTGKPPFHGLPDVEITYLFKQSEFPKTQSLGPIGDVIRGCWQGRFASADDVLKAMNFCDRTSLVTSVMDYVSAPPVRETTIAVSVLGLALFLVHRLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U7R8</accession>
    <name>A0A9P4U7R8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_436096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U7R8"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2439433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="225" mass="25194" checksum="8C03F2F980A45A77" modified="2023-09-13" version="1">MSGWGLGWFGGGTQKKEAPKKAILQLRGQLEMLNKREKHLQNQMDEQDTLARKHVNTNKTAAKSALRRKKQFEHSLEQTQSQIMTLEREVYSIETANINKETLDAMKNAGAAMKHIHAGLTIDKVDDVMEGLREQHAIGDEISEAITSGVATSAIDEDDLDEELDELQREQLDEQMLNTGPVPVGDKVGRLPQAPNAELKGKAPLRVEEDDEEEELRKLQAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U872</accession>
    <name>A0A9P4U872_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_110562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U872"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="124" mass="14165" checksum="EC6E1613EB982169" modified="2023-09-13" version="1">MKRKHQHVTQVSRPKLGSIRTCCKSGLWVLWIRSEPVWTLRTCSRRLKAWRRYAYADMPIWRLVRATDAGICCWASGSCSLRPQARQIAAVCSTPRVKLVDVANASHHTPCNRERDAAHNALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U918</accession>
    <name>A0A9P4U918_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_435521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U918"/>
    <dbReference type="OrthoDB" id="5419508at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="506" mass="56530" checksum="EF23659748FAAE4D" modified="2023-09-13" version="1">MSAAGTPYPRLPVALLQETVEATPLPSPDAIVKTYLLNVTSEILTLQTLTPSLGASSTDRYTPSLQVLHARLQDGHRSPFPGLENRSGEGFARTGKARKTAVSSAMDRPLADFEDMYYAILATVKEMHESIILRLNNGFVDPNALLFPSSQYTIHLFHEWLAHQWSILNEPSLVLALDVAVRKAFVDGHLCQALRSQVDSGQITHEEAEVARAQLYRSDVFDEMPGLSWVGNEHSAMINGRLNEKYRVVFQAEKQAQEKKARWAKKKDRFQKSAKVGPRAGGRRGSGEHRQQQRQVVAEQAQQAVDMPSTTTTTTTTTTTERQQVEQGHDGARQCQQVDQSAHDTPSLFQEEVEAWRLYTQQQMSSQRETQMHNHEDELRRKTPPAHTVEASPSPYSLCGKPTLDTPQREAHARTQPPAAHVQQDVQDADLAAQENTFPGTNPREVRAQRVTEYQAWLRESASDGARRRMGQRGQCHQSDMSDVSPQAFNGTDTPMDMDMDDDGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9A1</accession>
    <name>A0A9P4U9A1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9A1"/>
    <dbReference type="OrthoDB" id="3771551at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="271" mass="30226" checksum="C4F0DCE308ADD8AA" modified="2023-09-13" version="1">MAPSFARVEESAPQLSTIKFADVPSALRDQLRNAFEKASSIYTKAALEAPAASYGTQYEIKKAVIFTIPKRDPEFTTIRPGFSFAESANIALLDLVIDSSTINFAKLTALQCEGSPDEQQRANPGFLDCHAVEKGGLSWGMDTFGCLSLCILVEGDKDELRREAYFVQRVYTSGEDGPRAGGHSLSSEQSEPAQRSGFKFSLRLPAGAEKEKEKAEEGEDEDRLDRMMETGPRQSKKKTWGECTWEERRALFWRSRGTQEPMKNGSQVQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9C4</accession>
    <name>A0A9P4U9C4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_88334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9C4"/>
    <dbReference type="OrthoDB" id="10682272at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="267" mass="30189" checksum="012F9F0AE76E9138" modified="2023-09-13" version="1">MSPRPKSRVKREAIDETGGAATKRARTSATEVSSEDPFIATINAAVEQYREKDAVEKHSLREKIKTLEKALKAKEQLLFEESEKRMAEAKQHHQDLSCSQKTVQSYHEYTEQLQETVKVREGTISGLRSSLRVANATVRKMENEPHLQCEEVMNSKERVIKGLHDNLLVSNDALRNTKAELHLECAKVGDLMATNHEVQTQKDLWEKRAKAMYSAYEGVHDKNGRLIEKVEATLEACAPGGLSKKSRKMMDELKSCPLDELSDFHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA90</accession>
    <name>A0A9P4UA90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerol:H+ symporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_521619</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA90"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2444259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="637" mass="72769" checksum="7B4E0FDC14F2BFA3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAI1</accession>
    <name>A0A9P4UAI1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_474350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAI1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="147" mass="16569" checksum="4909C5D51253EE35" modified="2023-09-13" version="1">MVRPVLAQYLRPRRHHPITRSPFDVLQTLLPRCTVQTFHNPRLPGLESRCRVSEVSPLLKHTKPPSPIVSSLSAETAQPHRESRDPRESPGTQGGRATVAQRTRRRARRSGTHVHFAPDETRRDKTCILTDRQKTAAWVTSSAAMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAJ3</accession>
    <name>A0A9P4UAJ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">P171DRAFT_445896</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000762">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 20" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 27" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 20" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13 20" id="KW-0518">Myosin</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 19" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="62"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="25">
        <location>
            <begin position="969"/>
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            <end position="1879"/>
        </location>
    </feature>
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        <location>
            <begin position="1978"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="478"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="20">
        <location>
            <begin position="1505"/>
            <end position="1527"/>
        </location>
    </feature>
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        <location>
            <begin position="1851"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="2038"/>
            <end position="2128"/>
        </location>
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        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
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        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
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        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
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            <end position="598"/>
        </location>
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            <end position="1866"/>
        </location>
    </feature>
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            <end position="1888"/>
        </location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
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        </location>
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        <location>
            <position position="95"/>
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        <location>
            <begin position="1062"/>
            <end position="1069"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032645"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2442147.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="2128" mass="236779" checksum="013E0788AD0FF2C9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UB10</accession>
    <name>A0A9P4UB10_9PLEO</name>
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        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_521138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="175"/>
        </location>
    </feature>
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    </feature>
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    </evidence>
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            <dbReference type="Pfam" id="PF09791"/>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
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    </evidence>
    <sequence length="255" mass="27854" checksum="9ACA9C7BCA35EA1A" modified="2023-09-13" version="1">MEQLGRSVGLLALYRNLCASCRPTSPGNSLLLGSERAGLQNSDRIQRRFKGYIAPPGQQARPIEGYYAEILKKPLAKTSPATRTAPSPPPPEWEWLPKTGEEETLAKARNVFGSIAGPEERRKEIEAASHEVAGVLVPPKPEEPDNCCMSGCVNCVWDMYRDEMEEWAAKSTEARARMQAQRESGQGTGSIIAGKDTPTHVATSMDDDGGGSETNWVAPVSQEALFDDIPVGIREFMRTEKKLKERQQAGRAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">HEAT repeat protein-like protein</fullName>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
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                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="880"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1697"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1634"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2430"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2593"/>
            <end position="2643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1638"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2448"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2616"/>
            <end position="2631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2632"/>
            <end position="2643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2643" mass="296588" checksum="8305853CB806BBF5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBG0</accession>
    <name>A0A9P4UBG0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence/damage-inducible protein-like protein cinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_359065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBG0"/>
    <dbReference type="OrthoDB" id="2350783at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
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        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA C-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="176" mass="18573" checksum="DCBB4452971DE2EA" modified="2023-09-13" version="1">MASTFPPPELREIVQEVASLLQERKETISVAETAAGGLISAALLSFPGASRFYRGGLTLYTLEARVAFAGWTKQDIEDYAGPTTDIVKGLAEHTRATLGSTWTVSESGTAGPGGGVQGTERYREPGFVALAVAGEKGTEVRELVTGLGGDREGNMVRFAVEALKLVRDTIKDGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCX4</accession>
    <name>A0A9P4UCX4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_443775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="InterPro" id="IPR036047">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="657"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="78817" checksum="5097CC7A0488D8CE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD59</accession>
    <name>A0A9P4UD59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_412723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD59"/>
    <dbReference type="OrthoDB" id="3210378at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="77878" checksum="5E00FE3F13A22462" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDU2</accession>
    <name>A0A9P4UDU2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_410808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDU2"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="156"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="690" mass="75638" checksum="5243EBAA6BCDE573" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE44</accession>
    <name>A0A9P4UE44_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_408916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE44"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="753"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="981" mass="111924" checksum="56BE68DC3DE51BDF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE58</accession>
    <name>A0A9P4UE58_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_442028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE58"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="320" mass="33350" checksum="E30D2B8440371B4F" modified="2023-09-13" version="1">MSPSSQRHTGHSSCRVVVKPASPKNLWRSSCWHKLLSTCHCRLLNVEPAWRIEELRQRVVLAVDILSSSSVAACLGRGSFQLGRSRVTLASQVPYRLRSPGAGPDAPGPDPVLSKSRGLQSSKSTKGNSQRAKSTYTCCWFAISLARAAAAAAAAAAVAVVAAVAAVAAAASAAAAASAAAAAAAAEGEGEGAAAAVVSVSVSPAPREQADWGWREEAAGRGNFLFMWAPGAAFAFTFTVATSGPWQRARGRRRRRGAGIAAAAGHCMGRLGVLNHWYATISQRQGNSRWIRDKNRETAGRTRDAACYAGRVGTALLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEQ3</accession>
    <name>A0A9P4UEQ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_482765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEQ3"/>
    <dbReference type="OrthoDB" id="5332336at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052759">
        <property type="entry name" value="Metalloprotease_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43579">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43579:SF1">
        <property type="entry name" value="NEUTRAL METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M4 C-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="203" mass="22443" checksum="D941DF60F1003943" modified="2023-09-13" version="1">MDKHLIYLHYSVAHELAHGLLLEHLGFRTGAGSADEPTALWEHMADVVAIMYKHWAARNSTSASDWVVADKIFKATHVSAACRGSRDMKNPGTAWAYIHPTKGLISDKAAAHISQLAGSEPLTYYNMSTIPSRAFAEAVDLSGQPSYGLMGEIWWRTIMGLQKDKDSSINFKGFAKKTMETAQEYKTDNTIKQAWAKVGISIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFJ0</accession>
    <name>A0A9P4UFJ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_428266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFJ0"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002010">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="655" mass="70484" checksum="5AF5AB30CAFEC5EB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFM0</accession>
    <name>A0A9P4UFM0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbohydrate-binding module family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_516114</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFM0"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040393594" evidence="9">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="79"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2450169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="16383" checksum="819CE2419458C655" modified="2023-09-13" version="1">MCLALAFVLFLGLSHALSTSQSGDCGPAIGLHCTGSSFGPCCSQHGYCGSSSVYCGFGCQADYGSCSTSPFLELVPSPDGTCGSANNYTCVGSGYGECCSQHGYCGSTGEYCDNECRGNSCHECAPVGYSCTIDNSTQCCTQCCYFPTGDVQDGKCCDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFX4</accession>
    <name>A0A9P4UFX4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SPRY-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_377586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFX4"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="158"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="436"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2450499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="672" mass="73701" checksum="2A891CDC8FB3F8B4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG24</accession>
    <name>A0A9P4UG24_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_452450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG24"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF4">
        <property type="entry name" value="BLR3030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="529" mass="57162" checksum="2857EE275C8AC0B7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG70</accession>
    <name>A0A9P4UG70_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_510470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG70"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="281" mass="29723" checksum="18803E237F17DE3B" modified="2023-09-13" version="1" fragment="single">HPRSPVPSPPFNVLPTHITHAAAQHAPRSPCAPRPCPCHVAWRGTVSRRAPPAAASVSSDVLDTRPGCHAHAHAHAAATRAGVRSDTRVCVQLPLPRRIGRACWQGLALVLARWMGWGVVWHVCVGCPGRVRSGDGMGWDGSGVRREARYRGVEWSGGREGGRASSSWVGKGPMVSVLVILALDTLLLNASLELNFAGSVMGCEQMFGDVLFVWRWEAGYERGVGGGAGLGVRSATGCGRGFPCWACGYMAAMGWTTAGLHVLDGGGQALVKARLEADTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG80</accession>
    <name>A0A9P4UG80_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_470533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG80"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000007">
        <property type="entry name" value="Mitochondrial ribosomal protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32915" checksum="FCDB2FC84CCA9AA8" modified="2023-09-13" version="1">MATAIAAAKAGVQGAVLLASKPPATAAKTLKGSKLVDAMHRNLYPHLYQQGGGSAPNRKIRQQMGTMKRYKQVEAEREARKVSWFRNKMRTSSSSTSASLWPPSPASRSPLSFHWASNRLAAQPQKPRAIRKACSDPVAATTASQLALHDPTGARTRLFDRANPECARVGDILLVRQRTGEPFAGVCINIRRRGVDTAILLRGQLTRIGIEMWYKVYSPLVEGIEVVQRAQRKARRARLTYMRKEKHDRGSVENVVRVYLRQKAALGNAEGSKKKGAAAAAAMAGGGKRKGNVKGKKGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG94</accession>
    <name>A0A9P4UG94_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_406168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG94"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="43"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="364" mass="39500" checksum="B75EDD96952A6866" modified="2023-09-13" version="1">MIFSTLLFAATAAALPKALEHRQGGQNTMLRFGCSQVIIDRIDPLVNPGLAPSPHMHQVVGGNSFNTTMQSTDIAKISTCTTCGYSEDFSNYWTANLYFKAKNGTYKRVPQIPNRDLFNDKYTGKTNGGFVVYYVSPGKGKVTAFKPGFRMLVGDANNRVSKNLKSQTCFRCYTGPNFGGDNAAPCQDAKLDTEALPKAACPGGIRSNILYPTCWDGKNLDSPDHKSHVAYPKAGPALFTGSSVGGDCPSTHPVKIPQIMLEIVWDTRQFNNKADWPTDGSQPFVLSTGDATGYGQHGDYVFGWKDDSLQKAMDDAKGCMGANCGSLKTQQPDAGNTCKVPRRVNEDADGWLSELPGMEMPMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGB7</accession>
    <name>A0A9P4UGB7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH:ubiquinone oxidoreductase 30kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_427599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGB7"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="105"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2449406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="290" mass="33047" checksum="1D91A7045D0698DB" modified="2023-09-13" version="1">MALRQAVGRPLGHAVRSASCPRTAVRTFVATALRAKEVAADSPDAANLRYAPRDPTPSKLKAAIVNPTDRYKEKGEALHKYGQYLMSCIPKYIQQFSVWKDELTIYIPPAGVLPVFTFLKNHTAAEYTQISDITAVDYPTKDQRFEVVYNMLSIRHNSRLRVKTYADEATPVPSLCDLYDGANWYEREVYDMFGVFFVGHPDLRRIMTDYGFDGHPLRKDFPMTGYTEIRYDEEKKRIVVEPLEMTQAFRNFRGGSTAWEPVGLGDNKTPENFKLPTPKPEPPKEGEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UI97</accession>
    <name>A0A9P4UI97_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UI97"/>
    <dbReference type="OrthoDB" id="3797097at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="146" mass="16324" checksum="C97085F05F9DFF4B" modified="2023-09-13" version="1">MPPAASHMKDVTEFSAIEVPAGDTPASGKTRFTRAEKRKFARENNVVQAPQAPKKSSTKPKDDLRKFRPSKIDVYKLSPDQIDTYIALLEAKAKTGSSKPTSLADRVTRDHVKKERAGEKLKKELSVAKLEKIEKRIQLRIAKKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIA7</accession>
    <name>A0A9P4UIA7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_450383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIA7"/>
    <dbReference type="OrthoDB" id="5854584at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040467063" description="EamA domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="20280" checksum="AA68DE401DB21326" modified="2023-09-13" version="1">MSSTAAKSSSWLVLAVASGACAAFNGVFAKLTTTELTASWSGSIAHALGLSSSNKLVEYAIRGLFFGLNILFNAVMWGLFTRALTLASSTVRVSVINTSANFMITAILGLAIFSESLPGLWWLGAAMLVAGSVIIGRREEGVKETEGAAGSDPLLNAEGDAFRDEDAHERDDVELDSVRDGDKSSDDEDGVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJQ1</accession>
    <name>A0A9P4UJQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_492971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJQ1"/>
    <dbReference type="OrthoDB" id="3754729at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="170" mass="18996" checksum="58EE3D38ECF19517" modified="2023-09-13" version="1">MTRPSPEKAAALKLIRFESIYPWPDWPFAALAVLDPATGAFDHQHAFQEGMRYALTQIDGVHKLLCISPITEFQDYIKSTDISQYLADKKGTSATPTLVTDNMSVYTSFWMGGKFAIEGLQQGPIPVAAKMEGLLQCLACFAEEFRAVYEKVVQEHSVKPEVNKDWSGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UKD0</accession>
    <name>A0A9P4UKD0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_347383</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UKD0"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2452227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="496" mass="53150" checksum="E12147D60FBA3678" modified="2023-09-13" version="1">MNPRAWFSDLTPYFVYVLFVATLGPLLFGFHLSELNAPEDVIRCKKSSITAAAAHLPQCIKMEDLEWGVVGSMYTLGGLLGALSAGPLAGRYGRRRTMQLTSVFFIIGPVFESLSPNIGVMAVGRLLSGVGAGASVVVVPIYISEIAPPAQKGFFGAFTQIMCNVGILLTQLLGYFLSHDSYWRFVLAAGGVIGVLQSLGLFFSVESPKYLAEQGHTSQAKKVLRSLRGEDTDINDEFNSWSVDGTSECPELHCQANARPDEEQTLLRNEDEPSTPKTRSGKEEALSIAQVLRHPDYQKAAFAVIMIMLAQQLSGINSIVMYGVSLLADLLASNSALLNLAVSAVNIVVTTGCAPLPDKLGRKACLLQSLAGMGISSLLLAIGIMRAIPVLSAVAVLLFVSSFALGLGPVPFILSAELVGPEAVGATQSIALAANWIATFLVAQFFPLASAKLHGKVYIIFAALSAAFFVFISWFVPETKGKKNADEVWGRERRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P3X4</accession>
    <name>A0A9P4P3X4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CobW-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_437473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P3X4"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="9">
        <location>
            <begin position="49"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="10">
        <location>
            <begin position="300"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2437859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="402" mass="43435" checksum="DCE0343512690E41" modified="2023-09-13" version="1">MSGDASDDEVPDLVQPPINPGNDNDDTDNDEPPTLIPTTSSTPLKSKVPITIITGYLGAGKTTLLNYILTAYHGKRIAVILNEFGDSIDIEKQLTVSDTNSTSASKVPFVPLANGCICCSVKDVGVAAIENLMEANGDFDYILLETTGLADPGNVAPLFWLDEGLGSSIFLDGIVTLVDAKNLLKSLDEGYGDDEEALEGRKEHGHAGPLLTTAHLQISHADVVIINKTDLVSEEELEAVQQRVRSINALAKVSTTTKAEVPTLEGFILDLHAYDAVSAADLTFAEKGHSHIDPSISTSTIVFPALREEQVDRFDRWLRTVLWEDKLPDGKTYEKFEIHRLKGRIPVVRANILLVQGVRNVYDVNEGTETTSEDSSAKLVLIGKSVGQKAFEESLLATLGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P572</accession>
    <name>A0A9P4P572_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_450027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P572"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="264" mass="29820" checksum="51BB4EE25F6061ED" modified="2023-09-13" version="1">MPDSKRFQVSGLRCSAVRLPYPADEATERAFTTSNGVLLLCQNIVKPKPWAAFCFCFSEISTAGMMSFLAPFGLPSEWRTPNSFWFPTWALPLLYTKGLYQLHMSPLGDVLKFWSTKTISSVLARRKTPMRVEMSFLASLGLQPQQYSTTISFGPLQSRPRHFCARWYCCLSKTGNAKGMGFRRLINDVMSHVCFLRVQKLTVFKHMICLFLPPTIAKGSLLGFRKGSDLAQCLLLWRLKQKRGSGDVYIFKISSSLTQVSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5P6</accession>
    <name>A0A9P4P5P6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_505453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5P6"/>
    <dbReference type="OrthoDB" id="10465261at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="190" mass="20034" checksum="978616D0492E20BC" modified="2023-09-13" version="1">MPSDARRSIHGSQQAMRVLRAMVRTRSHSCRREGASPEAASKECTRLGTCTQRCRLAGGSVESDSSYFAGVKQAEAVGQSLAKGAAGATAEPRTLKQQGVSATESLALIHPLTGFAGDIPAASASASRVGRPARGHGQATGRQHMDNRRRSSNALALKSHQRSTHCAAGQLTRSDVARPVRPQTKRKPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6B1</accession>
    <name>A0A9P4P6B1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_526305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6B1"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="161"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="352"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="3">
        <location>
            <begin position="604"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2438027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="720" mass="78475" checksum="DDC81937176B652F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6K9</accession>
    <name>A0A9P4P6K9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_490999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6K9"/>
    <dbReference type="OrthoDB" id="3785861at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="911"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="855"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="953"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1055" mass="117505" checksum="75542BAC67928355" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7E0</accession>
    <name>A0A9P4P7E0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_449575</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7E0"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="431"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="518"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="569"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2437816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="594" mass="64006" checksum="74DCD8FF1066C949" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8K2</accession>
    <name>A0A9P4P8K2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_466595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8K2"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="57"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2439456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="545" mass="60244" checksum="961FCA8EAE230CCF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAD4</accession>
    <name>A0A9P4PAD4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_125150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAD4"/>
    <dbReference type="OrthoDB" id="3795566at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040343298" evidence="3">
        <location>
            <begin position="24"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="522" mass="57669" checksum="B21A37D3AB82AB36" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAH2</accession>
    <name>A0A9P4PAH2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_367768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAH2"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF9">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="278"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2440262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="625" mass="69763" checksum="74B7FAB4C14084D0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAI4</accession>
    <name>A0A9P4PAI4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_490330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAI4"/>
    <dbReference type="OrthoDB" id="3792672at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="702" mass="76568" checksum="4B0DB833547157E2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBM7</accession>
    <name>A0A9P4PBM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_498693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBM7"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040163232" description="Beta-galactosidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="8">
        <location>
            <begin position="24"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="9">
        <location>
            <begin position="386"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="10">
        <location>
            <begin position="529"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="600" mass="65453" checksum="601F4386D0DB03B4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBS6</accession>
    <name>A0A9P4PBS6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_434830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5338512at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <dbReference type="Pfam" id="PF20253"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2441211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1541" mass="173757" checksum="FC135071B89B3B93" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC99</accession>
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        </submittedName>
    </protein>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
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                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
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                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
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                <person name="Ohm R."/>
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                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
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                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2441722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="4158841at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="284" mass="30840" checksum="9F1FF81DD49BF8FF" modified="2023-09-13" version="1">MSNNKIQKVPSRLPAPALFVGPPSHNASATSLLPGTGADKPSRVPLTRQRSLLSPDGKRPPPPLASTSAYDGDPLKLTSSNPNAPFVRHQRQQNEAADVEASSRAEAIWAEMQNTLEEVELSAIKGPGMTVFGSEHSRALEDLRGAQIDLAKAWARSEAEDLDQSPEDRTTAGDTNANVADLLNIPERSMEKPNQSSPKAGSDLGGTFEKSKLEEETEKDIELSRKRREANDRYFEKVNRGVLEVVNKLEEVAKAMKTVESESKEIWSDNQSAETASETAPSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD69</accession>
    <name>A0A9P4PD69_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_84972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD69"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040128393" evidence="2">
        <location>
            <begin position="17"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="385" mass="43829" checksum="98B1460239A17C0A" modified="2023-09-13" version="1">MKLFSVLLLFAPGCLSRSYPQVGRIAPGEPFLPFERQQHNPNHSVSGINRAPALGSRALFPDDHPLLQTIAEGCSLIGMMSTRDEVAARFLKPAHTRKTAESPWTEWKSLKDWGYNFDEEGSYDAHAKHQKTYLDPVMRSLGLPELNVVEDGGSSEPRIWEHGRATIHDGVEYKRTKAWYQFFMDVEHGLLVTLVSYGPQYKGLQQTPPVTVLPKLKNLCDIMYLEYAHLAAQKNVPVNRLRYYMVDNVQNEETKAAVDYAIGVELTDWECHELTRLPRHTWDKKNVFEPDSEAYKALIASPSGRSAALLLATHKKVFGERRIIESVTFWCQTPDEINYNLLFTIKDHDEEEDDTDWEDEKESEDPGKPDFSVSPWPSATPRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD80</accession>
    <name>A0A9P4PD80_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_434643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD80"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="251"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="548"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="97066" checksum="4CFBFE6DD4B2648D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDD0</accession>
    <name>A0A9P4PDD0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress responsive A/B barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_82591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDD0"/>
    <dbReference type="OrthoDB" id="3830014at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="109" mass="11942" checksum="0F17EE6BFFFADFA3" modified="2023-09-13" version="1">MATTNPITRVTLFKIPSSSDAETLLSHFRGMPTNALKDGNPYLLSVTAGPTFEDPRSQGFNFAAISKFKNKEDMVYYDEECAAHAALKAFAKDVIQGIMMVYLEDGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDS4</accession>
    <name>A0A9P4PDS4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_417062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDS4"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2442140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="180" mass="19613" checksum="9C5DD4381560960C" modified="2023-09-13" version="1">MDHSHMDHGGHEGHSMPGMDHGPKCNMNMLFTWDTTDLCIVFKGWHISGTGTLLLSLLAIVLLTAGYEAVREASRRYDAHAKQIAEGRSGGDDLSNAARADDESSSLLWPGRHGRAGATTEQQTKVVKALFYAVQVFYSFFIMLLFMTYNGWVMLAVAVGAFVGYLLFSGGPPTKTAACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE68</accession>
    <name>A0A9P4PE68_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_394328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE68"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000027">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="85"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2441326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="304" mass="33756" checksum="9DC56AAE27B7D180" modified="2023-09-13" version="1">MSGRSFPLASILQYTVLAILGYVLAGAPLLSFVTGPTYEDRKARASTGRPSPLSHDKAAGLIIPERNMSCTEHMYKGLHVLSRDPLVVYVEGFLREDEVQHVVDVSQVHFTPSTVWSAGQERLDPTVRLSEKASVPRSPAVRCIEERARAFQGWRPYVFVEKLWAQKYGPGGHYAYHYDWSNALRGAGRISSFMVWLGDQCEGGGTRFPRLERPKDEAWCRFIDCGEDGSGDEGGTDENEMGMGVTFNPIKGNAVYWENMRTDGTGYEESWHAGLPVTSGTKIGLNIWSWLQEGYEPSSPQGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEM2</accession>
    <name>A0A9P4PEM2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_434210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEM2"/>
    <dbReference type="OrthoDB" id="3211582at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="200" mass="21810" checksum="F17D81C67C381CB7" modified="2023-09-13" version="1">MLEPLTAIFKNQSNSTSIRDPPLLAPLLQTTHVNYHLNTITMPLFGSHREPAPEPAPAQTRSSGFFSSHKTASPQPTTTTSPPARNRSLFNRRRSSSPSLNGTHTHTTTSPHKRNSLLHKTGSEDASIVSARERVMSAEAAEREADRALFAAKAAVRDAREHVKALEREAGEQARLAKAKQHAAKGLGKRGKALGRHDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFU6</accession>
    <name>A0A9P4PFU6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="13" type="ORF">P171DRAFT_417851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFU6"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="12">
        <location>
            <begin position="171"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="300"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="328"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2442573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="494" mass="55647" checksum="1BC76D66B9E43D88" modified="2023-09-13" version="1">MRTRQETEGIPRFADGETAGAHTADPMSDDPTQMFAPPINRAMKVLDRSFFQKTVNTSAARIFSPKDISRVRTDLDRSRDTLRTRLDGVRPDTDAARAAKGGKCLILKPEVVHNDRTTWSPTLQQLEQAGTVGVIPYELKLDYDYFTYSEVTSAIIPPPEKKNDDEIPTGFTLAGHVAHLNLRERYLPYKSLIATVLADKNPNVTTVINKLDNVGTENAYRTFQYEVLHGEDDLNVEVHEQGCKFNFDFAKVYWNTRLHTEHERLCGLFKEGEAICDVMAGVGPFAVPAGKKKCFVWANDLNPDSYRYLAENVKTNKVDAYVRAFNTDGTAFIRSSAAALLEDDRSVPIFPKVKFSRSAPKPTERPKPLRTLVQPRIFSHYVMNLPASAITFLPAFIGLYSNVPGMPSSKIRKLLSPHTDVKLPMIHVHCFSTKSKDDVAETKSICEEISRQLEFEVTPDTPELEVFHVRDVAPKKTMFCASFRLPEEVAFREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG91</accession>
    <name>A0A9P4PG91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_37163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG91"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="120" mass="14041" checksum="B0129CBCF558DA63" modified="2023-09-13" version="1">MVAVDDPKKQVALNGWTRQRRRRVAFSFLAYLIWVFWTYIIRCGGVRGRSCNHYQSIPRRDGGMVTQHVRRLDSGCLCMPSTPVHLGVRQMHWITLAMLRHYLHASLHWTRHNATLVMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH12</accession>
    <name>A0A9P4PH12_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_390732</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH12"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02130">
        <property type="entry name" value="PA_ScAPY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000093">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="AMINOPEPTIDASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040536826" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="151"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="263"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2442829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="509" mass="54786" checksum="125D50354CC98DF5" modified="2023-09-13" version="1">MRASISSLTVLAAGASALQIPLLSSEKQAPIEPAGDYHGDKPLVDSSALQDLISGDKLFARAKKLYEIAKLGEEEYNHPTRVIGSAGHDGTLSYIYETILALGHYYDISNQSFPAVSGNIFESRLVLGDEVPKSASPFGLTPPTKNREPVHGTVILVENEGCELGDFPSSVKGNIAFVKRGTCPFGTKSEHAGVKGAAAVVVYDLGSKDGIGGTLGTPSPNHVATFGIGSDDAKPVLKKLKNKKHVDAIAYVDAEVKQIATTNIIAQTTFGDPDNCVMLGAHSDSVAEGPGINDDGSGSISLLEVASQLTKFNVSNCVRFGWWAGEEEGLLGSDYYVASLPKEENQKIRLFMDYDMMASPNFAYQIYNATNSANPNGSEELRDLYIDWYNDQGLNYTFIPFDGRSDYDGFIRHGIPGGGIATGAEGVKTKEEVEQFGGKAGDWYDPCYHQLCDDLSNVNVTAWVVNTKLIAHSVATYARSFKGFPERTESVAATEYTEGVKYHGSKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH56</accession>
    <name>A0A9P4PH56_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_363956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH56"/>
    <dbReference type="OrthoDB" id="418131at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="172" mass="18636" checksum="4708C0C6493D1AC2" modified="2023-09-13" version="1">MPSPSPSEKLSLAASSTVYTYHCLCTHLLLATSTPLDALPTRNNSPDAAHMMPLPPPPAPPTKPRRPSNESPAPPPTDHYGLLLSTRLEHAPAMVTSDSGFEKRYLQRCARCNLVVGYHLDWHQFAADRAGRRDDVVYLLPGGFVTTSEMIMGKTPATSAAMGMVAVKEIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH87</accession>
    <name>A0A9P4PH87_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">P171DRAFT_431796</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PH87"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="14"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="185"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="296"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF2445030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="554" mass="60454" checksum="326A3481EDF3DFC0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHU7</accession>
    <name>A0A9P4PHU7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_433547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PHU7"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF60">
        <property type="entry name" value="BIOSYNTHESIS PROTEIN (TRI7), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="290"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2443249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="457" mass="51048" checksum="70D6D8A438E5D88F" modified="2023-09-13" version="1">MAPKAARAAYTPIPKREALAIVLAAYVPALLLCLYGRLPESVASFYAAHPVELVAGTFYLPMLGVMYLHPRSPLRLAIIPIVALGYFAYRTAVPRFIANRSRASFPEGPFYLLFLTAVDALVLRRIYLGQDGKEKSERLVTRDSTKTKANAQDTSGILSWRAIGWAHRVVFSYRAIGLPKEVPNLPKWSNKDPSYVPSRTAFLVKRGLAVVGAFLVIDFLGQQPKPDPEDFSAEKALLFPPAHALNGATIGARVFSTVLWWTILRLNIGLFYNLFSWFGVATFLTKPAGWPPYFGSVFDSYNLRRFWSVFWHTGLRNPLSSTANFFAYDVLRLPKGTLFGRYTSAYLTFALSGLVHTLMDNTAGIPLAKNTAWKLFVTQAIGITIEDFVESAYHRIAGPSSSKPTAWWKKIIGFVWVLVWMSWTTPSWSYQNMTHDGEPLYPFSAFASFQALTAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PI00</accession>
    <name>A0A9P4PI00_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_430833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PI00"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="82"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="583" mass="64848" checksum="78287DB2DDBF75E1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJH5</accession>
    <name>A0A9P4PJH5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_432377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJH5"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="593"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="692" mass="77767" checksum="0F26C4BB479B83EA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKF8</accession>
    <name>A0A9P4PKF8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_430983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKF8"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="219" mass="25017" checksum="42A3A6867CDA1C17" modified="2023-09-13" version="1">MARRPARCYRYCKNKPYPKSRFNRGVPDPKIRIFDLGRKRANADEFPLCIHLVSNEYEQLSSEALEAARICANKYLVKVAGKEGFHLRVRAHPYHVVRINKMLSCAGADRLQTGMRGAFGKPNGTVARVNIGQIILSVRTRDSNRATALEALRRSQYKFPGRQKIIVSKNWGFTSLRREDYVTKRQEGRIKIDGAYVQFLGNKGKLADNVRRFPDAFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKK7</accession>
    <name>A0A9P4PKK7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_431054</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKK7"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="14">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="15">
        <location>
            <begin position="131"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="16">
        <location>
            <begin position="253"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2445662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="396" mass="43428" checksum="7E970AF3C956AD3F" modified="2023-09-13" version="1">MTQPNGQTVPGPKLNGNTFLFTSESVGEGHPDKIADQVSDAILDACLREDPLSKVACETATKTGMVMVFGEITTKARLDYQKTIRDAIKDIGYDDSNKGFDYKTCNVLVAIEQQSPDIAQGLHYDEALENLGAGDQGIMFGYATDETPELLPLTLLLSHKLNSAMKEARNNGELPWLRPDTKTQVTVEYAHDNGAVIPLRVDTVVVSAQHSEDITTEELRKEIKEKIIKKVIPAKYLDDKTVYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYLGRWIAKSLVNAGLARRVLVQLSYAIGVAEPLSLYVDSYGTSDKSSEELVEIIKANFNMRPGVIVKELNLTNPIYNQTAKNGHFTNQEFTWEKPKTLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLB5</accession>
    <name>A0A9P4PLB5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cap binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_357575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLB5"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000035">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000045">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="461"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="669"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="939"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="108746" checksum="E2D18313E2EC3F3E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLU1</accession>
    <name>A0A9P4PLU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLU1"/>
    <dbReference type="OrthoDB" id="5153521at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="174" mass="18834" checksum="7154053136F7CFC2" modified="2023-09-13" version="1">MASEHIFTSDLRSEAKESIRDKTSRVKWAHGASYGPGRRAAENRPRPARVATVPKALKSTAGIDKNRTAIRNDIACASGDSSADEDVEHPSVAPVPDAGVTYSFDAERGPSHGSQILGIALAKAIESYEVRQTDKLIKEEYEVLRLDDDALSPGPKAARKGVAPEDEDYEFIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLZ1</accession>
    <name>A0A9P4PLZ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_272416</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLZ1"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="286"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2445738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="575" mass="65623" checksum="403F87078493CD6E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMI4</accession>
    <name>A0A9P4PMI4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_238217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMI4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53902" checksum="3934DDE7A72F61F5" modified="2023-09-13" version="1">MPSAIGPHDGRKARRKRCNACVRRKIKCHGGIPCDYCRRTTQTCESPTKPTTFMPVFVGETVNKARSKQVIHTAVRPTGFPFLQSPTPPAYENNLLYFFRSFLTMNNLSNDRLPVVADLINFMADAPALRDAIFAVAVHHRGQQSPKVISTSDYQALQSYGRSVRHIKDLITTDTFSNDPSALWTTFFLGLFELMRDSTGTTWLSHFLHGTCAMLKLLEPKSLNLMEPHNSNRRIFFLHIRVFEISRSLIYSSPTFLWDAKWTAAIADLWEGDSAALWHPKEALFDILPSFSELSIRALRFSLDGSQFSLEVPHDLAQSLAGEGFALQEKLQRWYAETKFWEKMCQDDQTSPIFSKRLDTELMISYAYYHAINIYLSGTYDYHQLWTGPAAPCAPILARNEIDLHVSRILYFSRSLLAYGVSGIFLFFPLRVAGARAVDLSLRQDILSLFQLTSQRGFVVAEALMDELLERWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMZ4</accession>
    <name>A0A9P4PMZ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMZ4"/>
    <dbReference type="OrthoDB" id="10674093at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="351" mass="38874" checksum="0594D2D208DF41AC" modified="2023-09-13" version="1">MQVDCGSQNSLQYTNATDNVTIENPFRPKEGLYSKNISSNWTWQLDTKSPNHKTDGNTSLRQSLSLSISPPPSPGLFYQNDYIGCGLIIHGAKYDRVVKSQGGLQGDCTGFISEECRKAILSEASVVLIIAEFKAKYLNVKKKDKHKHKENPEPVEHDVCQAVSVLKSNRTMTKCKDDFMPNVWFETFLWASSALNSSQCTNSTSSFVAHTWGASTYNSTSFRAYNNLTTSIDPIVTTLHMASPIGRLELSNWNRNQTPNTLPKTPSRKEMSDRNRRSSRRHVVDSSESDSEAGGSASTSDEEYGFPGGMGYGGFSEAAREGYYAGYSMILSLPKADREGVDVSEYISNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN99</accession>
    <name>A0A9P4PN99_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_356004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN99"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2447331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="451" mass="49168" checksum="EF9445BCA068D11C" modified="2023-09-13" version="1">MPLPMPGSTSRELYWARVKAVFHGADPRVCAAFWLFGLINNVLYVIILSSALDIVGPNVPKGVVLLADVIPSFVTKLCAPYFIHKIPYNIRILIFCALSACGMLVIALTPQLQDAKTITIKMCGVMLASLSSGGGELSFLGLTHYYGHFALASWGSGTGGAGLIGAGAYAVLTTSLQISPRNALLAFSFLPVIMLVSFFVILPHGPLRASSSHQAGYEAVEDDDTLDENDDLASYPENASLLASSMHSASGRSFTSTKSNGLPSALLGFRANLRRARGLFFPYMLPLLLVYIAEYTINQGVAPTLLFPLSNSPFDEYRSFYSTYGAIYQVGVFISRSSTPFIRIHHLYFPSFLQVANLALLTLHAMFDFLPNFYVVCVIIFWEGLLGGLVYVSTFAEITDNVPREDREFSLGATSVSDSGGICIAGFVGMAFEVWLCKWQTQHGRDYCKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNB1</accession>
    <name>A0A9P4PNB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_357457</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNB1"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="171"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2446413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="606" mass="65242" checksum="B46740B8D825A7AA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNH8</accession>
    <name>A0A9P4PNH8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NadR/Ttd14 AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_520005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNH8"/>
    <dbReference type="OrthoDB" id="6118920at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
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            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="127" mass="14211" checksum="386D681B516BD431" modified="2023-09-13" version="1">MTTSPTRALQLQNHILDAQFAAENAASPATCYISDRSGLDPIVYAQLFASEQAARDMLALEEWTELERRMKAGIVVLSGTEEWMHIDSAFRELLAARDIHYTVVPKDVESLEARVKLVLEHLNWVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP03</accession>
    <name>A0A9P4PP03_9PLEO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_258556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP03"/>
    <dbReference type="OrthoDB" id="3799848at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        <location>
            <begin position="756"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="787" mass="85866" checksum="8ADBB3DEFE5C38E9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQR0</accession>
    <name>A0A9P4PQR0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
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            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQR0"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="505" mass="57796" checksum="F24B404F44669D86" modified="2023-09-13" version="1">MASDENDPRGNRNRNHERDHWDEHNPFITFRRFADSQVSSLMNTVFTLPATIANYKNVHVARENCLFGRADKAKCEHLHELEEETAKVIAECRELYRTGHVEQALDKGEALLQLNYAADELRKQIVEGSRGSSFTGKHGYDREVAQLGNSRSAGLVSQARDGNSSKELVERVANEKGQQWGWSWDWGFPKPFDGDEDISNRRDRCRRWRRRREESMSTHTQADEHSDAAEERSMSSDQQGWVDERQRWLHQLDEVLLPIFQQIFRHESAEAEDVYDMAGNSNVAAELVRVGVSRDAFEDLLRSQNGYPLIPSEKLGQSDHLLHDSWSRRFFDRTDRSFVGRPSTNEYPKRVPWEGEETAEEPNYEYAHDHEDQHDEPPSPKSKQGSWSSDVPETELEAYERLLGPIPAFGGNSETEGRPSILSTLTTTERTVHPDGTVATKVVLKNRFNDGREESSETVYTERGQGSAGQGSDRPSRILEAAAQHKLQQQPRENNNSKTGWFWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQR1</accession>
    <name>A0A9P4PQR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_226982</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="205"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="356" mass="37963" checksum="0585297B47839DF6" modified="2023-09-13" version="1">MSGNTNSDILLAGAVAAFTVDLLVYPLDTLKTRLQSPNYAKVYTNAATQKPNSAMFRGLYQGVGSVIIATLPSSGAFFTTYERTKAFFNHINPPTSSHPNGLIPTPIVHAGASSIAELVSCAILTPAEVIKQNAQMVSAGSPTNATVQTLAKFKSNPLALWRGYTALAGRNLPFTALQFPMFEKMKEAIKEHRNRKGIRTGTIVESAWITAVSAGAAGSVAAVVTTPIDVVKTRIMLSAVDDAAHEVSSQKKNAKVSSEGLVDAFGKTVESSKPTAKSTVQNLNPLTSPEKKGKKSAWKIGQEIVHDKGFKGLWRGGALRAVWTFVGSGLYLGVYESGRVYLASRRGEYVDEADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR39</accession>
    <name>A0A9P4PR39_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR39"/>
    <dbReference type="OrthoDB" id="3799661at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="366" mass="41193" checksum="E534E69D427D3885" modified="2023-09-13" version="1">MHEKRSSSAALNLSPRPPSRCGMKTPRHNLKLTANMSQIPTSNQKKNPSVGFEKLDVPRGRASSVSAQTIVDENPDFEIRRAAIKRRGTHVALVKVSWWDVFKATIFGPKTLKRHLAATVEWAEVEDSHAEFFDERDNWYTLTVSAYKREGREFIPARCVLDTGCSQGNIISTKLARRLGFNDSDYQPLTPREENGGAVATGHTHKVLGCIRVSWFSETSPKVFNSMRFLVSDTADVDLVIGTRSIQKEKLLNPPNLGLEQKIHDLAMPSDDERQALAQNVATLDAEKLKAEILVEDTKEGTKERTSAEKALKKAKNNWKVANWKLKIYDVDLDLKRTNSEKTQRALMDKKKGLKKSLAGKEKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRA3</accession>
    <name>A0A9P4PRA3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_507584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRA3"/>
    <dbReference type="OrthoDB" id="3687719at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="173"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="556" mass="63241" checksum="0E769104638A1158" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRK6</accession>
    <name>A0A9P4PRK6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_354080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRK6"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF8">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2448063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="317" mass="35615" checksum="E2DBDBCA2F795096" modified="2023-09-13" version="1">MVKPWTEWVVSTRVKVSHRSYGLLTTIAENWQSGRVLCIGDATHRHPPINGLGSNTCISDAFNLAWKLAYVIKGWSSSSLLDTLTIERKLVGDAIVRRANDGMEAHRRLWKIIGLDHNSRKTFSGLLGADSKEGAEMRDRYREALEATELEIQALIIHVNQIYLDSKAIVVEIGDEAPNSPNLEPLRDVKVSTYPGYHLPHVWLVTNGRSRRVSNLVLCGQGRFALLTGIGGDGWIRAIESILGPDGASARAYKIAYCDYIECYREEYPVRGMDENGAILVRPDHFVAWRCQNLVKNRVRKLSSVFDQILGQQERCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRR4</accession>
    <name>A0A9P4PRR4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_352685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRR4"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="106"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="548" mass="60126" checksum="21FCCF8C9A022B92" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSN4</accession>
    <name>A0A9P4PSN4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_209097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSN4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="147" mass="16104" checksum="80B0831FA57DB70E" modified="2023-09-13" version="1">MRAFPMLYIPFSINASSIRDSAMRPRERRRYCSQQPVGGCSYISVSGPIAIKRSSNQHPAARPSGPAGALDSPQYADLPPSQYSKPPPWSPRPAGKITPYVRSHRVPAVGRRQPAEQHPRPIAGTTSKRDACLSPCCYGTLIHLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTG2</accession>
    <name>A0A9P4PTG2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_352137</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTG2"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040177039" description="Glucoamylase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="14">
        <location>
            <begin position="510"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2448511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="626" mass="68177" checksum="FA81B99DB0221971" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVB6</accession>
    <name>A0A9P4PVB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_427182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVB6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="135" mass="14810" checksum="F85F363DC0B3763C" modified="2023-09-13" version="1">MLLYVAVRSRPVYGLLLVPAIHARRSEPIRHDFVKAVGRWLSAANDTAAAARSPCAVPRRSDRIVGASRWGFEKCHVDDIAPQAWRWLGQGCHVLMGLTRVSPLCLGIEATDDDVPRLFAGCSGGFLCAQSWSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVN6</accession>
    <name>A0A9P4PVN6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-CoA ligase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_467889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVN6"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000017">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000340">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF6">
        <property type="entry name" value="SYNTHETASE SUBUNIT ALPHA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="732" mass="77711" checksum="404ED1D8AE8FA6A7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWX8</accession>
    <name>A0A9P4PWX8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_402800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWX8"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2450419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="317" mass="34873" checksum="161FB87B7A404424" modified="2023-09-13" version="1">MRLIIREDTETAAEYVAEYIIGRINTFTPTAERPFVLGLPTGSSPVPIYSALVTAHQMGRISFHHVVTFNMDEYVGFPREHPESYYTFMHTNLFNHVDFDPENINILNGNAPDLQEECTMYEAKIQEYGGIHLFLGGVGSDGHIAFNEPGSSLSSQTRLKSLAYETMLANARFFNGDLSLVPRMALTVGVQTIMNAKEVVIIATGASKALAIQSAIEGSVNHMCTLSCLQLHPCSLVVVDQDATMELKVKTVAYFKGVERTIQKSTKVRRPLVQTNGFHAGPDKAEPDELSPDSMSSRIQTSQSFPVRSATISYGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX18</accession>
    <name>A0A9P4PX18_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_426264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX18"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001796">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2451812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="37131" checksum="293CF3EF034FB78E" modified="2023-09-13" version="1">MSIPSTQTVAWIEDPGPSGKLTIRSGVSIQEPSQDEILVKLDCSGICHSDCRNIFGMGKYTDIPGHEGVGEVVKLGPGAKETLMGKRVGIKWLYSSCKKCSACKKGNINNCSKQSNTGRTTLGTLQQYVVAHADFVSLIPDGVKSEVAAPLLCAGLSLAGAVSKLAPEVEAGEFVVIVGAGGGLGHIGVQIATIKGYKVIAIDSGAEKEQLAKEMGSVAFIDYAKQDVVQAVKDLTDGEGAHGLICVAGSERAYQQAPQLIRNNGVFVCVGLPPDDFMFPMSPIHIANRGLVIRGSSTGTSEQMDELLQLAKEGKITPKIEVYDFEESPKIIQELDKYEVTGRKVVRAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXB3</accession>
    <name>A0A9P4PXB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_426380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXB3"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="7">
        <location>
            <begin position="389"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2451962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="601" mass="63993" checksum="54AFE7A2705C0AF5" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXE3</accession>
    <name>A0A9P4PXE3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_348994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXE3"/>
    <dbReference type="OrthoDB" id="3438274at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="277" mass="31036" checksum="455F93D000E7BD6F" modified="2023-09-13" version="1">MDTADPEHDDLFEDATAALDALSEADDASPPPYTATLDGLKRAREIKEQISKRLNILGPKPMRARSRTVEEDPDNQAIKVMRQEHNMSWEAIVAQLNMERLERGEPQTWTPAAVYSRFVRNAPRIAAAQGEVGFSPRDYMHLRNPASHPAAQLPGAINKPSGYQFGAGGGRKRVRDDEHAAKDLADNLRHPVSDTLSEQTEILKKADMTELMMEAVATAEQEFWGTVANALEKKTGKFFDVKVLESRFHEIKWYVVIIGNSDGDTNRVQIAAVSRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXX8</accession>
    <name>A0A9P4PXX8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_425773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXX8"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="8">
        <location>
            <begin position="23"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="9">
        <location>
            <begin position="349"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="7">
        <location>
            <begin position="547"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="692"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="699"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="834" mass="94085" checksum="5BCFAB75686B2326" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYE8</accession>
    <name>A0A9P4PYE8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_153258</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000180">
        <property type="entry name" value="Related to UDP-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000552">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000004">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000110">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="562"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="922"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="956"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1157"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1417"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="640"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="640"/>
            <end position="652"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2451136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1650" mass="183911" checksum="3D4884DFCEA105C3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYM5</accession>
    <name>A0A9P4PYM5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_426103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2451608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="118" mass="12737" checksum="ECDFFF6C9CEBBFC4" modified="2023-09-13" version="1">MDVAGVFAPLWSLSVPSQCGKRARRGLTSHVTIVSTCSLASTATLTYLWKAFTWTTSVDRWHNTARLKRYNLRAAFLLGHCGVDVCLLTGSCARFDGPTEPAMPSTDIINTLKSSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZ33</accession>
    <name>A0A9P4PZ33_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_12916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="281" mass="30485" checksum="F1424A5F0BBCF50D" modified="2023-09-13" version="1">MDRQEKGAVVPSMGCSVGVPCTRSNYSASRTETLAAQRRGRTRTDGRQQGPGSRQDSRRGSAVCRVGDEEETGRGGGQAEGVPSHTGDWRRRTPDAASERRRATKLALELQLQLEPEPARRDGRPGIWGVGKRQRAQNKAPSSPWDGAMCTPALGWPAPPLPVVGTAHWPPMLQDAQKESCGAVQVPKRVRDGYGCGHWKATRCSSPRASVQAFHGSSVEHAGGGVHVCTVHCAPPSCRDEGVDEVLRCRQRQPPPPPPAPESLSMQPLAFWQHEDNLYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZU2</accession>
    <name>A0A9P4PZU2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_493533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZU2"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="203"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="364" mass="40027" checksum="760051D71B27ACD5" modified="2023-09-13" version="1">MAARSRPRGGQMKDEIDEERHLWNTIRADGRRFDQLMAQSDTLQEKILELAGQQEARKARGDAPSSRIDNELDAVLRENIKLSEEMLTLIKSDQNNDICEQLTVLSALRSADTDSSTSRATAPGKSRDRGQNKRKLTDAADDRDSIATDSPAVPSPKVVLGKDRDRLLPKSGGSRAGSVPVGRESSVKVEDDKDDVKGKKKQTKQRLTVHTEVLYRAPRSRSGPIQQEGEGTLHRITSVIGEGKQRRYEIIDSDPDPMTPNIPFRASVATIVPIPPAVSNLSLPSLEAKKNVLAVYPGTTTFYKAEVVDGWKSGGNGKGDGIKKEGGSEEKPGKEAYVTLRFEGEDEVDMVNSVERRYVLPDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5B7</accession>
    <name>A0A9P4U5B7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_178659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5B7"/>
    <dbReference type="OrthoDB" id="3792619at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="212" mass="23859" checksum="67F0BCB34F7FA3B4" modified="2023-09-13" version="1">MMMAFRVWREVEHSSWHAFVFGRTLFMRAESQSLNSTARILALVDNRTPFAPPRPTTSNIYPPSASTSTKRASITTMSFPLEGLAIYDTDDRVHRARIMAEYRRQALEELDRIRSFQQLHSLHENPQIDATPARETTPKVPVPVSVPDTALERGVGNGVTDKPLAAASATPHQITQTPRKPTRKVKEIFKRTPKKKVLSPSSLPHQSQPLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5M0</accession>
    <name>A0A9P4U5M0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_467801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5M0"/>
    <dbReference type="OrthoDB" id="4216719at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="600" mass="66989" checksum="2732E5E10F8648F2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U838</accession>
    <name>A0A9P4U838_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_111572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U838"/>
    <dbReference type="OrthoDB" id="3789253at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040306918" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18558" checksum="7CBB035DB3E44071" modified="2023-09-13" version="1">MITVAIKMLSLLFTLASFIMTAMSAPSSQAPNSHHLNCTFSLRVTEACHLATTPSLSTSAALTTVLSPWGNDITNATEGVNIDAAPLSIDARSPQENIAGTLDIERPNNTKVEFRWTYGPSGGRPVTERWSEDTAGTEGRYGCAVRQDWDAPGTRCDGAHPTDERVSGGSVVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U858</accession>
    <name>A0A9P4U858_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_435334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U858"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="45"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="149"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2440541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="384" mass="41983" checksum="A4C942CDEA8F0E28" modified="2023-09-13" version="1">MASQTPVKLAILDDYHNIAAQHFSAIDPSKLEVVTFNDTLPSYTHPRTTDADRKKLVDRLRPFAALSTMRERTPFPGELLRQLPNLKVIFATGTQFETFDKDTIKELGIQLVAAPGKGRTDGKGRGPAARAKIDIKKGGGHPTTQHAWAMILALARNIAADDAVVKGKGAAPGWQTELAVGMQGKTLGLVGFGRIGALVARVGLLAWGMKIVCWSANLNQERADQLAEEVGLPVTGGGIVAHDEPTFKAVGKKELFKNSDVISLHYVLSPRSRGIVGAQELGWMKPSGLLINTSRGPLIHEAALLDTIRSGRIRGVALDVFDIEPLPADSPWRSESWDEKGKSRVLLTPHMGYVEEETLQTWYDETVENVERYVQGKQLLHRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8L4</accession>
    <name>A0A9P4U8L4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_497312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8L4"/>
    <dbReference type="OrthoDB" id="5421601at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37202" checksum="3E33771C8CF94447" modified="2023-09-13" version="1">MADQLSSGKVPMRSSTNNTHMDHELDTLQFAFGDIAVASNNDQVSKMKIEPNPTGTKLLHDLPRDIVTLNILPLCKPRDLVALVQTCKAMPGLVSPLLYKRLDLSDRPSHLPLAIHARVSFAERMQKQNRAIQGLLRDPDIAKHVRILKLTIGANYSLQSSQDLYRSFELLENVEHVDIHGILLRGFAPDNMPLTLQSGLARNIFPHAKTIKLRGIILFWLVERILLGGQKPELTTVELTRLTPGAALWPEDSNFLFHRHGQAYLAYFVRSRAQRLERWAVDGEERDTGPYDEDVVDMSLEDIRTYFLKPQVARHFNLWLEGVAAHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U924</accession>
    <name>A0A9P4U924_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_53206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U924"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="2">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="606" mass="66570" checksum="0A9DB976A60ACDED" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U940</accession>
    <name>A0A9P4U940_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_54545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U940"/>
    <dbReference type="OrthoDB" id="10605003at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="158" mass="17022" checksum="45286C86006FEE8A" modified="2023-09-13" version="1">MCKSPRSHSPLPSPMLPSRETGGVQVTSRSEKAIGASSRPTAAIRHSPAVLDTSEIAGPANSFPEGCHDHVSFVSFCCSYYKACAAPLASGRRPKKQSRQLRRLLSNHRINCLHAAHSQTPPVRLLSCFRPCAAASIASARLAVRAGCSNPGCRRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9K9</accession>
    <name>A0A9P4U9K9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9K9"/>
    <dbReference type="OrthoDB" id="3799742at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="249" mass="26730" checksum="F8FB83AF9727822A" modified="2023-09-13" version="1">MFLSVKERARQIALGQFTAPTTSAPVASLIDIAPEPQSAVAPPRKTGARDTTQQTAAESSKTKPSKSAPAKEATPKVAPPQRAPPPKTAPPKATPAPASKPPSSKTPAPPPEAPPSKKPSSKSRTPKEPPTTEAPPSKKSSSKSKTPKEPPSPRPSSYKSPQITAVPGLGHRRLAIVLKQRSSGAWYAALKDTEADKYLKSWMNREKTFKTRREALEAYLGFATKMRERSEVSWFPMSPRAGSPKGKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9N2</accession>
    <name>A0A9P4U9N2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_433853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9N2"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000058">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="202"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2442325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="482" mass="55101" checksum="C20870DEF515279D" modified="2023-09-13" version="1">MSLNVTTARLTVRCASQRARAGPPACKRRSFFSSVSSRPSTVKRRARRDDESPALPTPTPIPHEQLVHSPANAGQVDAYPAKTVAVSIDENPRTFDTVFLRDSCTCPKCVDPHSRQKLFQTSDIPLEIEGKARTVQDEKKGWVLEVEWQNDVPGYGPEHRTVHSIDWLRRALNTEVELRAGVRYDDRVLWDRDTMTKNNKWIDYADWMSQDTVLFDALAHLNQYGLLFLKNVPESEASVVDIASRVGTLKDTFYGRTWDVRSKPQAENIAYTPQFLGLHMDLLYTSNPPHLQLLHSLRARTPGGESFFSDSFHAAQKLHDASKTHFTTLCTFPVTYHYHHPTHHYHYTRPTIELHPHPKYSEPTNLALHRVNWSPPFQGPFEARIGGESQTALRHYIAAASAYEGLLSAEENLFEYRLKEGECVIFDNRRVLHARRAFDATKGERWLKGAYVDDDVFFSRLRVLEERFAGRWVADGVVRPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9T0</accession>
    <name>A0A9P4U9T0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9T0"/>
    <dbReference type="OrthoDB" id="4268580at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="130" mass="14250" checksum="A25D0FA751D15564" modified="2023-09-13" version="1">MPPLHVQLDRSTTFVEQLSHQPTSGPIVLINVISIPPKANVESFLHTWRQSAEVLKAAPGYISTQLHRGIGDGNFLINYAVWESNETLKNGLNLPAFRKVCEEFPEGTEFRASVVEKLAVDGVCVGVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA88</accession>
    <name>A0A9P4UA88_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_496737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2441998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA88"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="15"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="255" mass="28214" checksum="F5AA915FE6AD14FB" modified="2023-09-13" version="1" fragment="single">QTGTAPENWLAYSHIIINNLVALYDLGGGGEPVLRGVSLDIPAGAKIAICGRSGSGKSSLLGCILRLLEVDAGSRITIDGIDITTLPRQVVRTAVAVVPQHPFFLKHASIRDNLVVHRQQQQQQQQQTDNDDRVLHILRRLKIEDVVDRLGGLDSPLETDSLSQGQRQLLCIARAMLAGRRIILIDEASSNVDERSEMLIREVMREQLASCIVIAVANFDRVAVMSNGRLLEWDSPRALLKRDSEFRRLWDLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAE0</accession>
    <name>A0A9P4UAE0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_62301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAE0"/>
    <dbReference type="OrthoDB" id="3783140at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025213">
        <property type="entry name" value="Sim4_Fta2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13095">
        <property type="entry name" value="FTA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36229" checksum="2D22717E68B47EC3" modified="2023-09-13" version="1">MPPRTSRRKAQSLASATVAPRVAQKAGLLPRIKGPKTGPFRHPDFDTSSDFHFEELLDEPSSSSSEGGEGYVFKAVLSGRTYAVKFKFYDIEEGRYRFSNSQNEKISDAELIGNLDPFNAECRAYGCIEEIRAKYREKGIEIGPIAMPCHGYMSITPSHEREFVDRFGPLEFQRCAKDEGTELRALVKRYSPHKHIDPKKRPVKLMLRDLEIMHENGLYPIDIHAENYREGLLVDFGMALTEPSCVLNVVDDYVADQERGRGLGAFDDMIKDAGIKTKIRAANGPGWRNRTRAGTIAKDRAEFIQLVNRRGLRTEKQSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAI7</accession>
    <name>A0A9P4UAI7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_494917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAI7"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="531" mass="60564" checksum="0224173533634D90" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAU5</accession>
    <name>A0A9P4UAU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_360032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAU5"/>
    <dbReference type="OrthoDB" id="5345494at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="456" mass="49884" checksum="C24DC4B2132494A9" modified="2023-09-13" version="1">MGPLTLDNAHPHSLADLLSNSLVLRQTAPYLPVASIFALAATSKALHHVVFHSPDVFRYLDLSTVKSAIVPYAPLDSGGISWRAERIDESLTEDEFYSGPIRGIFSKLQRRHVLHNVQTLVLDGLSVPADLVREIIAENTFNVRILSIREAKHLNERKLQQVLRYAARPGRPAGTPKIKGIYFFGQREAVQEKRKENTTNKKSTSPSPKGVTSSQGAQIGAEWNHKSSEALSAALSPSSDKWYQCSGRMMPKRASLEWAETLKACEGIIAFDAVLCRGPRHDPARAFISNSDSESSGLPHPASYLSPAVATVALGSKGCETCHSCPERPAVFGQSPSAELPLLNPIPLHSSSLRAAQIPHTVDGSKPPPLFVRCEDCLKGRWCERCHKWWDEDCYTVSAVAQRTELQQTEFMENATTDGTAHMLPKQSIKVHMGLCVNSCLVGEMMAGAGSNGMWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBA7</accession>
    <name>A0A9P4UBA7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcofluor white hypersensitive protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_521447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2444050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
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        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
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        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="281"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="455"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="687"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2444050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="952" mass="106352" checksum="435589786DD3163F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBD1</accession>
    <name>A0A9P4UBD1_9PLEO</name>
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        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">P171DRAFT_23166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2443991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBD1"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2443991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBI4</accession>
    <name>A0A9P4UBI4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_455336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBI4"/>
    <dbReference type="OrthoDB" id="2306919at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="225" mass="24906" checksum="5A40676E48087D27" modified="2023-09-13" version="1">MAHPKPKPTLASLLDTLLPTVHLTKPPPHPTHPSLTPVISSLLLHPTIEAALHLLNADLPSAHFLVRHMQAPPAIEGMLLHSILHRSEGDMPNARAWASDAMDASDGWVPKHKGAERLDFNTVQAMKGKVAGGKRFAEFVYGGNKAGAERLIEDVERWRKEKGAEGEEELAARIQGELEKVLEWCRKKFGEGQWADARAAWVKHGEEVRKMGEDMVSGDKGFRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBQ5</accession>
    <name>A0A9P4UBQ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_432635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBQ5"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040144035" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="422" mass="46163" checksum="184F478BB29FECB4" modified="2023-09-13" version="1">MLSSLLYRLVPLIAFFLVSGLSLPPPTGPYNVGTKPYVLKHTTLNDPVAPEGVSKSLLVNVYYPTHDEAPAQKYIWDGLSAAYDVYYGVPNGTFSNITANLALNGKPLSRKEHDKLRLPTLLFGPAMAGPPSRFFTGLVSEMASRGYPVVTVDHPWEAPYIEYPNGTGFVGKDFTWSPCQEVYDYIHAYRIADNSAVIDALPKVSKKLGIPFDLKRFAFFGHSLGGSAAISQILAERKWTASHGKRFLGAINIDGQFFGIGATNSSSLDARVPTLLLASEGHDPKAGFDPTWALFESFQSSWTKSLRIMGHSNHTDYSDLIFLKQANGFAGGEGVITAERFSQVSRQVVGDFFGMLVGKGEGVLQGSKKVHEAFPEVTFDYNGTGNPCTPAEICWPTPPEFLPPSCGSSQETLRRWFLDAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC96</accession>
    <name>A0A9P4UC96_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_522372</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC96"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="13">
        <location>
            <begin position="167"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2443902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="699" mass="79943" checksum="5B81B2B650DCF24C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCK3</accession>
    <name>A0A9P4UCK3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_360718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCK3"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000389">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="46"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2444458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="245" mass="27427" checksum="70552497FF53608E" modified="2023-09-13" version="1">MGAPFDFAPERPEHIEQILNGLDRYNPETTTVFQDYVMQQCENQTYDCYANLALLKLYQFNPHLARDETITNILVKALTVFPSPDFSLCLALLPSHTLAPLSTSSHTPAAGDAPLSEAVQKLNHLKNLLEGANYADFWSTLDSDDLYADLVADVSGFEELMRVRIAATVSQSVREVEKSILEGWLDLSGKEFDHFVGTVCGWNVDGDKIKVPINKDNEAKGTVVRENVKFDQFSRVVRRAFEQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCP8</accession>
    <name>A0A9P4UCP8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_443108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCP8"/>
    <dbReference type="OrthoDB" id="5347452at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="404" mass="42747" checksum="2A7E8351CDC641DB" modified="2023-09-13" version="1">MAALPLVHSIAFPAPSPTVLNPAEKAVIGWTPRTTPGPRHRAAAKLGKRQTEYIDKRPELCGWIDFGKSSLACSTDRICVLYTVSSGAGGVSGGMAGCCASDNSQDCGWVNSCVPYDAWTKKSCDAACQSNTFVRKCTNALSPYCVTWTYPSDGAADYGCADDNSGVVTVTPSWSDSESVYRITLPTLSGEAVTGWDGEASSSVESESPTSSFIPSTSVDPSPSDPEASGNSNSSTPQPQAPEKKTSVGLIAGAAIGGLVVLFLIGAAVIFFCVKRRKAKQIANNQTIIAAQQAQSQHQNHLPEYKPPIQAPPPPAPIQSPHPQQPGYYAPHEQKVNYQTHVHDQGLQSPVLSSPSTPAPPYVQPYYAAPNPSMSPMPEERYEVDGISAVQGQRPEAHEMGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD42</accession>
    <name>A0A9P4UD42_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_224942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD42"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2447424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="219" mass="23935" checksum="72D53099BFEF4ADF" modified="2023-09-13" version="1">MSTLPPPEGPQTPLSQAPTALTPTTTTSAASTFTFPPIYAFPPFFTLQPNPTTLSSQLHSWSTLLQSHCRHTRLTTLTLIDALPHPPFTNPTTRRSLSLADARTLISWMASPDGGHRAEWIATSSGGKAGRAGDAAPARCWVYWKRPEEWAAVLEEWVERTGQRGSVITLYEIGESEATRREEFHGIDGDLLAKSLQVCVKRGKAQVFGAEGSEGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDH9</accession>
    <name>A0A9P4UDH9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_265174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDH9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="51" mass="5774" checksum="3693512CCF3B9F01" modified="2023-09-13" version="1">MVVRTIVQPAPNDVHPTRYSPIDDCHFLIPILLASASPYFNIPVPEHIIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDW7</accession>
    <name>A0A9P4UDW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_358122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDW7"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="58"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="8">
        <location>
            <begin position="189"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2445838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="242" mass="27510" checksum="1CCCB18E4905C983" modified="2023-09-13" version="1">MDIDDLLAEVAVDTTPLETRDLQELTRAWVAERVAPEILAWPAELMERVLERVRRQIELVEDQTGNLDPKTNFRLIVVQTEVERFKFLVRSFLRARLRKVWRWMGEGKREANVLQVDTHPLHILAQHTASADDDANASHPLLSPAEYQYLTSHQALLAAHYGASFLSQFPNSLQRMDDTTGGISMVDKPDEDAAVFVRVLRDVGEVAVEGTDKRLEMKRGDVWVVRWSAVRGWVGSGDLEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDX7</accession>
    <name>A0A9P4UDX7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ferric-chelate reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">P171DRAFT_461218</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDX7"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040457935" evidence="13">
        <location>
            <begin position="18"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="427"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF2448294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="742" mass="84306" checksum="183C25B0C3439CD4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE89</accession>
    <name>A0A9P4UE89_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_429830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE89"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="261" mass="29405" checksum="EC8D4374DF81A0E5" modified="2023-09-13" version="1">MAGINAAVELLALLTAIVLLSTGYLNVYALAVVHAGYLIQRSFRQPSTKTVKNQSESWIMWMIASPLGTVFARIATLIITIQQATVSLAKISNTLPQSDAVLGYTCATPEYLDPNLFTWSSHTLATLALLYAGSYVRFSAYAELGTNFTYRLAKPDQLVTSGLYAYVRHPSYTGLLAVLMAMYSLFFRQRGLLSCWAPLVDERLVKEDWVGYAIVIIGFSLPIWLFMVKRVGEEEAMMQKEFGQKWEQYCKRTKRFVPFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFA8</accession>
    <name>A0A9P4UFA8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_429984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFA8"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2447052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="484" mass="51940" checksum="2C0D68E804C2D27B" modified="2023-09-13" version="1">MALRFSTKRFATALRASRANCGSARYASTAAALKGSSLPQDMKDSIEREASLPTPDPPSTSKTAGLVNQQLPYMVPTYVRPPPMFEKGEGCYLYDVENRKYLDFTSGIAVNALGHCDPGVSQAIAEQAQLLMHTSNLYHNPLTGLLSKQLIQLTHATGGFATATRTFICNSGSEANEAAIKFARKVGKEVAPGKDKYDIVSFNGSFHGRTMGSLSATPNPKYQKPFAPMVPGFRYGTFNDVDAVNDLVTEATCGVIVEPIQGEGGVNVATPEFLLALRKRCTEVGAVLIYDEIQCGLGRTGTFWAHASYPKEAHPDIVTTAKALGNGFPIGATIVNDFVCDHIKTGDHGTTFGGNPLGCRVASYILSRLSSPEILDSVPVKSAAFKKHFAALQERFPGRVKEVRGQGLILGLQLDEDPTPIVTAARERGLLIITCGTNTLRFVPPLIITEAEIDAGMAIVAEAMESVWTKGEQVPGTPGQQEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFF1</accession>
    <name>A0A9P4UFF1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MT-A70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_429085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFF1"/>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="442" mass="50187" checksum="62042817EF6E9A33" modified="2023-09-13" version="1">MQPNTAILFQNADRDVTLIDIPKSIAIAQGRPDSLLSTAPLEVPYQLHEEPKTSRAKKNHSSHFTDLHIEYRSTIHAALAEIRSHISGPWCLPRKLITQVLKHGEMQLEDPEKEIESRLQEWAALAESKEEDTHFDFQKMMASIGATPDPNATDIEPVSHKWLVSYTPPRDDAHVQSNQASDPWTSSFHNPENHPLDLHVQENVTPAGREAPAYRFTIPPHATFFLSDSTHSDVFRAAFRQLTDDYVLPRHFDLVLLDPPWPNRSAKRKGAYEQAGGMRHMKKMLLGMDIDSYLEHNALVGVWITNKEAMRTQVLGPGGLFEKWNVGLVEEWVWVKVTTAGEPMFDIDSALRKPYEVLLLGRAAPNAWTTMAHARATKKKIVAAVPDVHSRKPCLKELLEPYMPDAKEYSALEVFSRNLVGGWTSWGNEVIKYNWDRYWAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFJ4</accession>
    <name>A0A9P4UFJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_215867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFJ4"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="314"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="382" mass="44133" checksum="70FE939F7AF713A6" modified="2023-09-13" version="1">MADSASPIGIANLPNQRHKIVAKRGANFTIMVAGESGLGKTTFINTLFSTTIKNYADHKRRHVKQMDKTVEIEITKAELEEKFFKVRLTVIDTPGFGDYVNNRDSWQPIIEFLDDQHESFMLQEQQPKRSDKIDLRVHACLYFIRPTGHTLKPLDIEVMKKLCTRVNLIPVVAKADTLSPSDLAKFKSRVRAVLEAQGIKFYQPQLEDDDQAAMAHAQGLINAMPFSVIGSEKDVQTNDGRTVKGRQYAWGVAEVENEEHCDFKKLRAILIRTHMLDLIHTTEENHYEAYRAQQMETRKFGEARPRKLDNPKFKEEEEALRKRFTEQVKVEEQRFRQWEQKLISERDRLNKDLEASHAMIKNLEAEVESLQSTMGNRSHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFL3</accession>
    <name>A0A9P4UFL3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_511636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFL3"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="4">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2447367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="331" mass="35115" checksum="DBACFF6AB9CCDE9F" modified="2023-09-13" version="1">MTLPAGIYCPIVSFFEPTLDQQLDIPTHVRHVQFLGRAGVQGVVVQGSTGEAVALSSEEKKTLIKSAKDALEEIGSQALVIAGTVGAQSTRQAIELSRDASQAGADYVLVLPPSFYPAAMNPDSILGFYNELASASPIPVIVYSYPGVCSGINMDSDLLIRIAAHPNVHGVKHTDHDVGRMARMVRAREQLAPFTVLGGATDYLLGAAAYGVQGAITGSANVAPRVCIKVFGLASTGRIEEAKTLALEISRAEWALGKGNILGTKYATVYANGYPGTAALCRRPLPVVSDATRQHVEQECSDIIALERQLEKEGYDGRLKSRTNGKTNGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFM8</accession>
    <name>A0A9P4UFM8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_452708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFM8"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="648"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="744"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="805"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2447412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="854" mass="91536" checksum="31FAD91A1C3830AA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFR5</accession>
    <name>A0A9P4UFR5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_460048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFR5"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="5"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2450319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="644" mass="72647" checksum="EDD37AB924286889" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGA2</accession>
    <name>A0A9P4UGA2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Karyogamy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_191029</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KAR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGA2"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04163">
        <property type="entry name" value="Tht1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040208327" description="Karyogamy protein 5" evidence="13">
        <location>
            <begin position="25"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="562"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2449361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="70665" checksum="0708F6CA4544260A" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGF8</accession>
    <name>A0A9P4UGF8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_469291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGF8"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="284"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2449150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="460" mass="49038" checksum="E6B4E890B69C3765" modified="2023-09-13" version="1">MAVERRARGFIELRHTLSCWGWSLGRRISPSNHPKSHSPAPHCIAPLAQDQNITLAPRPASPPVLEPGLQSITNALHCPSMPPHSLHGAHRTKWRPTTLLHRHTSILLMLLAQLCSAILATIGRVLRTGHGDDSNEGMGTSEILLAMSLTTTLLSWPTARLHSVPSLPLGPPSARPLLALRSIAGAIAIWTFYYTLRTLPLSTASILNFLAPTLASLVLSLFPPSPHANSGGISPPQIAAALASLTGATCVLQPWNPSPSPSPTSTTTGTTSTTTTSSSQLALALLAALLSIVASATSYITLAHLSRTVHPSLTLAHFSTATLTLSALLLLLAHREPLHLPPTPLQWVLVLVLGVLGFGMHWLMTASLAREGDAKRPLNFVYTQIVWVVVADKVVWGVQPDAWKYLGGALIVGSAVFVASTREGHQYALVDGDGDGGEEEDELELEMGKERAEVAKDVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGG6</accession>
    <name>A0A9P4UGG6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_332532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGG6"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="149" mass="16638" checksum="DBE2E9CEB11750F7" modified="2023-09-13" version="1" fragment="single">LLEHGAEMEYTRKLGLLRTPLQRASENGNLDIVRYLVDKGAQIDTPPVRSGATALQLAALKGHVDIVAYLISKGANVNYPPAQGDGRTAFEAAAEWGRFDTMSLLMKHYVDLDQEFGDPPRSQYERARSFAEKNGQMASKRFVEDLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGI6</accession>
    <name>A0A9P4UGI6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_405010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGI6"/>
    <dbReference type="OrthoDB" id="5280838at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="488" mass="55210" checksum="353F3FAECE92B268" modified="2023-09-13" version="1">MVSYPDSQGAERSLTIRRRPSVTSTSHSSRASTVRRHRPHRSHFGGSSHQPQNEFPVFTHTGDVEIVISNGRKEQRYLLHKLILAQCSGFFEAGLSDEWAAAGEGSAQSATSAALARVPQGALPEKKVWKYELDWGRDDDLPMLIQKKAQPTLFGGDAASSQPPALRNKPPAPQAGFFRSMANFSSLHVPTTPSDPDDDTFRDYDNLLRVFYNYPPALDPVNIANAYVECKSLLLIADMYDALDVIGPRVDHHLLRFQGRLWKQIAKYPPSYLKLGYMARSKAIFSEAMVHVVGQWPQGMNQLRGQVAEPVLELVEDKVDEMDELKAKVEVKLFRLTLTTSRGERVTPSNNWLEWMAISLFRQWLAENTTPPPAPILKSPRQYSRNGGDTPLPPPPPFNTGRIFKLLGTGGSSYLGRDECKRFLKLSPEHYNRDNLKRFERRIEEIKNKAKDAVKPLMRNFLELDLREGGLPYLTCTRIDPQDFPWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGY0</accession>
    <name>A0A9P4UGY0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_481111</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGY0"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040396926" description="Peptidase S54 rhomboid domain-containing protein" evidence="8">
        <location>
            <begin position="16"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="119"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="316" mass="34729" checksum="9CC6B44C8DCE48E8" modified="2023-09-13" version="1">MWWIIAAAGAGFAWSVKDTPPQPSPSIALRKPGLWALGASTTAYVGLAAMQGFHDRCTDGSYSRSLKKKKEEYILRRSSPLVSHRGLSLTMVGLNLAVFMHCQSAPRKLWRLADSPSGTWTLLTCAFCHKDIQHLSANMASLVPEIPHMLQVCGQSPYQFIAFYVSAAIFSSYAQRAVSYIRWTQRWTSRFGVGTPLSMGASGVAMAVFAASCFAQPSWASPSFLLSTLTLGWQVTNDLNGLFYSDEAIGFAAHLAGAAFGAMYAYFNADCYIWSKLVRLFSGIRSGRNLPKPPTQTIHHDNLDLNEIVRRLNESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH59</accession>
    <name>A0A9P4UH59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pectin lyase</fullName>
            <ecNumber evidence="7">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_348857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="7"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH59"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040483419" description="pectin lyase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="10">
        <location>
            <begin position="104"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2450306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="388" mass="39788" checksum="162B1EBAA527CF4E" modified="2023-09-13" version="1">MKFSAAAFALASAISVEGAALGERGTYSVKGAAEGFAKGVTGGGSAPCAVPSSPSQLKSWLGDNVARCIVLDKEYNFKGSEGSVTENGCRPASNKCPGNGGQDAINLASWCTNGNAGVGSKTIKVTYDKAGISGLLVGSNKSIIGAGNKGVLRGKGLRIANGAKNVIVQNIHITELNPQFIWGGDALAIDGSDQVWVDHNKFSLIGRQMLVLGNGASNRVTVSNNEFDGVTSWSATCDGHHYWAIYLTGSNDMVTLKGNYIHHTSGRSPKTGGNSLIHAVNNYWYANTGHAFDNGAGSQIVAEGNVFQNVNTPLLEKKGSFFASPSTGANAVCSASLKHTCQMNSFGSSGTLGGADTGFLANFAGKNVATAQVGSASAIQNGSGVGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHD6</accession>
    <name>A0A9P4UHD6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_480549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHD6"/>
    <dbReference type="OrthoDB" id="10326153at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040133323" evidence="1">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="108" mass="11766" checksum="A881C8AE473ED709" modified="2023-09-13" version="1">MYLINIILNLCFLASSTAAILSLPDPDGDFCATAYGYLIPNGVNLYKNTCGSVSSNKAATATNAQNLNCVTCWFFSGDNCGSDIVWYGLIAPKQKIYFNPARSYICRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHS4</accession>
    <name>A0A9P4UHS4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="16">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_426882</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="16"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHS4"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="4 15 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="90"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2450530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="342" mass="37670" checksum="65C1D11881C52ADB" modified="2023-09-13" version="1">MFAQRIFRPANTLTQQVRRYASTDAPKSGGSNGLLYTGVALAAVSGGYFYMRRGAPTGQAGNAPPSAEANKTPASTAGQIAKAAFTGGEQGFLSLKLDKSEIINHNTKKLTFLLPEEDMESGLHVASAVITKFKGPEMQKPVIRPYTPVSDVDRKGTVEFIIKKYPNGPMSEHMHNLEPGQRLDIKGPIPKYQWTPNKHEHVAMIAGGTGITPMWQVANAIFKNPEDKTKVTLVFGNLTEQDVLLKHELEHLENTYPQRFRAFYVLDNPPEQWQGGKGHVTKELLKTVLPEPKEGEKIKIFVCGPPGMYKAISGGKKSPQDQGELAGYLKDLGYSKDQVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UK67</accession>
    <name>A0A9P4UK67_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_459838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UK67"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000023">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2452047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="545" mass="62131" checksum="840F2FF75F08A126" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P3S9</accession>
    <name>A0A9P4P3S9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_491652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P3S9"/>
    <dbReference type="OrthoDB" id="5393057at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="2">
        <location>
            <begin position="204"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="503" mass="54692" checksum="07AE7F23CB6EE513" modified="2023-09-13" version="1">MVLKKRFTSLIKRTNSHEEPVADNVDTPEANAARGVRLFCESGAANLGEEVLHLPVIVESAVASPQAAQAAANQIRKFLSKENYDRPHVQYNAVMLIRILADNPGASFTKNIDKQFADTVKQLLRNGRDPSVSQILRETLDSIHRDKAYDANLNTLFAMWTKEKKLMADAAKHVPRGGITQAPRWPDPNLPQGFNSGHRGGGLPPPVELAARIEEARTSAKLLLQLVQSTPANELLGNELVKEFAERCTSAQRSVQTYINYDNPPPDDDTMLTLIETNEQLSLAASKHQRAVLQARRAIGAAPSPPVPSNTYNNINNNYSALPPVPAPATTYNTPPVQQSAPQSEIPILPPLGLEASEPKSNNLASYKKDGLPLPPALQAGPGRPRSNSNSAQDTEDNPFADHHTYSAPAGPPPGQTGESAPANGYTPYRQGYQPTPSYLGRQESAANNVTMHGAGHSNLSEEEEYARGYPASNRPKTPEESHQRHGSDVSPLTDRGTVTYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P594</accession>
    <name>A0A9P4P594_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_437061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P594"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="95" mass="10999" checksum="14FD98704FF5C665" modified="2023-09-13" version="1">MFLTPDKVGLLQFWDCDNTELHRRSSLLRLGNKGKFAHRAPSMANHSRTRFTALNRQELYEVPEWHRPHCRVLVRPPYVSIQSSTTQADPCGVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5W2</accession>
    <name>A0A9P4P5W2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_373734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5W2"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2437328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="111" mass="12157" checksum="2EB3ECBB80ABE3D0" modified="2023-09-13" version="1">MSTVEERELAIHPIVVTSVQHNTQVVSNIRNLTASLFGVAAGTLGLESYPGFIFYLVGSFIVSALIFALRTDGKPGDYFHRPLGDMWGGDVFNGLSSFVLTWTLFYGLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P630</accession>
    <name>A0A9P4P630_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_166990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P630"/>
    <dbReference type="OrthoDB" id="10689004at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="353" mass="37443" checksum="268114FDF10B9D5E" modified="2023-09-13" version="1">MSERAIVGLSKRGGLGHNKKLLGKGRKGRKERRDALSRLDSGAVVCVRLGWTDRDGLGALSQPWLLISRVLRAARNSLAITAVIWRRANGIVCLALASPVDWAAIGVPERRPTFRLLPPTADTTTTRCAPPTCQGHSGVVVRLSLSPPTPWGSVAAATAASAATAAIDNGVQRSAAPVTCHHSPLTTNHPPPTTHHHSPAQSPDPPPLSSNSTRASGFSGRAMHMCAFVGSLALQLGACLLAAKTGGDAATSRTRPRDTEALGEPRNVRACEATTPPLPFAPVLVKPDPLPTFTQQIVTRTACIRLCPPRLRAAARTYAGPKCACKTDGTLPRKPLNKICLRLFSHPHWQTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P670</accession>
    <name>A0A9P4P670_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_506514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P670"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2437231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="574" mass="63730" checksum="C2002E2C640E40C7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7M5</accession>
    <name>A0A9P4P7M5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_114556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7M5"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052963">
        <property type="entry name" value="Pantetheine_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492:SF2">
        <property type="entry name" value="[ACYL-CARRIER-PROTEIN] PHOSPHODIESTERASE PPTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="342" mass="38622" checksum="3912244FB8DDAE67" modified="2023-09-13" version="1">MDPLIATATAADAPSETIDTPPPPSAEPAVEPARLWALSDLHLSYKGNREALAKLEPRPNDGLIICGDVGETAEHLRMCFSTARACFKQLWWVPGNHELFTMPSSNGKRGEDKYMECVEVAREFGVLTPEDDFVVWEGEGGPCVIAPIFTLYDYSFRPDHVLLEDALEWAGEENILATDEHLLHNDPYASRVEWCNALVERAQAKLSEAVMENLGTRLVIINHWPLREDLVNIPLVPRFVIWCGTKQTEDWHNTYNAKVVVSGHLHVRRTDWKDNTRFEEVSLGYPKQWQECQERGMDINDLLREILPGSDPPPPGEPTTLWRRYGKGTTTTPPIFLKGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7Q2</accession>
    <name>A0A9P4P7Q2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_157559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7Q2"/>
    <dbReference type="OrthoDB" id="5331891at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="444"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="640" mass="71750" checksum="6718D62E72D4161E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7U5</accession>
    <name>A0A9P4P7U5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_490457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7U5"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="400" mass="44851" checksum="3A55C31D68E2EEB2" modified="2023-09-13" version="1">MSTLEPESAIWYATCWLVLITRLVSRKLHHGSWKALSIDDYLICVAMISMTVLTGATHIVVSSSSNLIAPGEDTSTFSADEIRKRIFGSKLVLVVEQMQCITIWLVKACLLLMYKRMTALLPQHKIVIIVSAYTALGFVVMEILYLGVWCRPFSQYWAVPSSNPQCSAATNHLITNTVLNISSDIMIIAIPMPLLFKVKLPRKNKAILLGIFLIGTFNIVAAVLNKYYSFTHPFGVEWTAWYLRESYTAFLCANLPLTYPLVQRIFKLKNWSHHSYSGRYLSGSLQRSAWQSGLRSQRKSRIELKSNPQHGGISKTVSVNVSNSRNVHDLQRSESEERIYGPPTSRIELEQKALDGRTDQHLWAPGVSIEMSPSSPASAKAESMTTTGSIQSLEDAHVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P807</accession>
    <name>A0A9P4P807_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_398337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P807"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2438393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="232" mass="24629" checksum="67C75AC11AE9D26D" modified="2023-09-13" version="1">MGCFSSKEKGDETEMTRPAQTEGGSVPPSIPHPGTSTGDDVSPGHQTPKQTGGPEKQPTNPENPIVFFDITIGGRSAGRIQMELYMDVVPATAENFRRFCTGEADGGYKGSIFHRVIPSFMIQGGDFINGDGTGSTSIFGSESFDDENFNLKHTRPGLLSMANSGPNTNGCQFFVLTDTTPHLDGKHVVFGDVIGGMNVVREIENTQTGAGDRPVQDVVISNCGQLSGQKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P870</accession>
    <name>A0A9P4P870_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_458870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P870"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="493"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="912" mass="102096" checksum="86DB64AC91849194" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8H2</accession>
    <name>A0A9P4P8H2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_422841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8H2"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="225" mass="24654" checksum="F92D3C1D9B39E6C3" modified="2023-09-13" version="1">MSPTPPTRYGMIVFTGFQALDVFGPLSTLNVLSRTHKMDLAILAESLTPVSTNPSPNPFVSTGFGQEIVPTHTFQDAPEVEVLLVPGGFGTRNKATMAPVEAYIRTVFPTVKYVITICTGSAILAGIGLLDHRRATTNKSTWDAVVALGPRVEWVRKARWVVDESEGVTPVWSSSGVSAGIDVTFAFIERMYGGETAERVANVMEYGRWRDEGWDPFAEVWEREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9G5</accession>
    <name>A0A9P4P9G5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nicotianamine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_457594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nicotianamine synthase (NAS)-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9G5"/>
    <dbReference type="OrthoDB" id="1858069at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030410">
        <property type="term" value="F:nicotianamine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030418">
        <property type="term" value="P:nicotianamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004298">
        <property type="entry name" value="Nicotian_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266:SF12">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03059">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51142">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2439707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="315" mass="34048" checksum="A2B1B7075D30FAC9" modified="2023-09-13" version="1">MDQQVARGKHGHTRVDTPVSTPPPTPTPATAAAQDLYREIKTIYQQLAPLPSLAPCDLVNALLTRLVTICIQPCSPDVVDHFHRLDAAATLCHNLQNLCAIAEGELERHWAHKTLQDAGPHPNPLRTRTLLATFPYHANYLSLSHLEASLLTPFLTHPPSTIAFIGSGPLPLTSLCLLAHFPTATITNIDRDADALAVSSALTEKLGYADRMTFACEDAADASGGRTDWEAFDVVFLAALVGMRSPEKVGVLRGLRGRLRVGTVVVCRSARGMRGVLYPVLELSEELQGAGFEVLAELHPWNGVVNSVVVLRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9X4</accession>
    <name>A0A9P4P9X4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_366526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9X4"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="851"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="967"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1004"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="106"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="858"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="718"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="742"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2441099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1032" mass="112599" checksum="C98DCC8B96DAC064" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PA93</accession>
    <name>A0A9P4PA93_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Spindle pole body component alp6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_436014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PA93"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="216"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="526"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="792"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="885"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="919" mass="103005" checksum="82DA626D76B9DED7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAY4</accession>
    <name>A0A9P4PAY4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_466219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAY4"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2439691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1047" mass="118842" checksum="479A3AFEC11E855C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB75</accession>
    <name>A0A9P4PB75_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF647-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_434422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB75"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055412">
        <property type="entry name" value="UVB_sens_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24160">
        <property type="entry name" value="UVB_sens_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="6">
        <location>
            <begin position="40"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Root UVB sensitive protein C-terminal" evidence="7">
        <location>
            <begin position="340"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2441804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="456" mass="49688" checksum="131CE3094E9E584E" modified="2023-09-13" version="1">MTPAGTLELSERDDAGNITVTFIESAAGKGRSRVDAVRSRESKSYAQQLLEVFLPAGYPHTVTEDYIQYQIYDSLQAFSSSIAGLLSSRAVLEGVGVGDADASPTAALLLSVLQDSMGRIATILFAHRLGTSLEPECKMYRLAADVFNDTAMVLDCLSPAFPKATRVVILSFSSVLRSLCGVCAGSSKASLSAHFAKRGNLGELNAKDSSQETVISLLGMLAGSIVVSWVTTPMATWSTLIALLSIHLATNYAAVKSVSMRSLNRQRANIVLSSLVHDGRILSPAEVSARERIFERDGALRWVDGSVLGHCRIGVPLEKMLHYMGRRQNRSGAVDLQELSLADVVRLYQDEAYLLWSCGSEAVIILKQDCTPLDQLKAWTQALLLARKGSTRDEAKDGEHDTSGGRLDELRFALEEVQELFQAYETKLRVAGWDLDVAVLETRPGMRVQVETKWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBB9</accession>
    <name>A0A9P4PBB9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_447876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBB9"/>
    <dbReference type="OrthoDB" id="3801318at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="169"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="239" mass="28163" checksum="B98109FD7F5822B8" modified="2023-09-13" version="1">MDDFNPRVFYLCMSSPDGYINFASNRLIPSTRYEDLYEAIVNQDDNLFNTLMSDSEWEGEDEDEEEEEDNRIEDLVVRQGMIDEDRLADITIEQVIQPTRHRWIHVWQDEVLQQYLDDDDEDEQRREMIAELPRIEDVRVLNESLEYVNPDILKEDEDDEEEKDVPKECSICLNPYFNDPDEMPEGFDFSVVRTTCNHIFHKACLMECFDTPAEGNGVGKCPMCRKWLCYDPSADNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PC66</accession>
    <name>A0A9P4PC66_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_98794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PC66"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000114">
        <property type="entry name" value="H /K ATPase alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="839"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="913"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="972"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1010"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1043"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="10">
        <location>
            <begin position="100"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1080" mass="119557" checksum="1FA092E3DE0B803C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCB6</accession>
    <name>A0A9P4PCB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_447365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCB6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="456" mass="48065" checksum="68DB3182035F2CD3" modified="2023-09-13" version="1">MLKTRAPIIRRSSAVASSTASSCKSSSATSLNSARTLPLAPKLCQDRPLKAKLIKDNAPIVSVPGTASNEEKTKNKDRKRKAATLEVVSEEHIPAVNTAKTSSKSIDPITELLFPSVPASEVKDSATSPKKVASDGATPDSPSKRVARQKKPAVDPFRNDIRMGTSGKMAAGSGTRSIHKPTPAKAAKPAPTNLPPKTASLTPEVKVALTNPLRRKSTPAPDGNAASTALKKLKAYSIAAAYSKQSSTILTDLNPHKIPGMVNKLVAADKSIAKPRGAAAKAATVWKPKPRDEAYGGRTIPASKTAGLSKGSKKLLKSMGENTLATKPPAVNKNNLGKILDKGENQPGMRSMISAASHHPAMAAKRKRENEEVGIEGATKSAKRMVQHTGMTFQMNGIAFDDSDSAGDEAFMSDVPSFLSSLGENDSTAVPTSFVKETKKPLPKKRTPKEMTLTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDD5</accession>
    <name>A0A9P4PDD5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_85286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDD5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="161" mass="17876" checksum="20B95257A182F490" modified="2023-09-13" version="1">MQTLSNRQSRRCHDRQFTVHVADRFVFASLKLLSIRPQFDIGLAVSLPFTPPDIACRGTTGKLGFRTLTSLSEGASFEMSIPGPARFCEAPAERGRSETLMGNRLVNFQDYRSRAKWSKGGNSLIRGEVKPIPVALHDARSIPRFALALPARVGRRPSSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDJ8</accession>
    <name>A0A9P4PDJ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CSI2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_419217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDJ8"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040309051" description="CSI2 protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="38405" checksum="E0084A5EE192CE96" modified="2023-09-13" version="1">MRMSIRLAGVLALAAPAVLAQDNQDDKTTDQPSATQATDKDTQTSAAAQTTDAPETTDTPSTTEEDHATAAATQTRGGEGNFLSLLPSQAGVGIPVVGVPDTAGAAFMQKSDLPDGTVFICVGAILAFFGLGVLVWRGLVAWSLHRSVKRAALAQNLADLKDMSAIPGARKRGMYNVVGASSTMSLDHLSAAPTGTSKPPKPFASTATSTPPKSNSLFFSPTAGGSTGLRDSVANRSSQYLPAGYYAAGNAQVAQGSPMTHVGGAGAHLPTHSLAMPGNRYSARSGISPPQSPSLPPSRGYDRAPPSRDGLSIYNRNSVATLGSPTGRAGVYGIDHGSASQLSLNVPGGSTTGGRAPSAYLDDLFENHGSGSKDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDP8</accession>
    <name>A0A9P4PDP8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Citrinin biosynthesis transporter CtnC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_433459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDP8"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="95"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="537" mass="58267" checksum="C8BAEBC5701A2364" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDS9</accession>
    <name>A0A9P4PDS9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_434889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDS9"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="54"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="244" mass="26505" checksum="E10545F26BE14E84" modified="2023-09-13" version="1">MAAPRTLRPLFRGPTHRIANLQQRRTFLPNPFQSSLNPLAGSAPPQTLTAKRILPYPAAPIYSIVSDVQSYSSFLPYCQSSAVTRWSSPDSTYARKWPSEASLVVGWGNLTESFTSRVFCVPGRIVESIGGDTETDLNAKDIAHHLEGARDGDKGARGAGNGLMTHLRSRWTIEALGENETEVSLALEFAFSNPMYTALSAGVAPKVADTMVKAFEKRVQTLLDGNPEVAKAELGKLEGSTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE09</accession>
    <name>A0A9P4PE09_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_433894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE09"/>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2442381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="68431" checksum="4A8B9472D5782D87" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PE64</accession>
    <name>A0A9P4PE64_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PQ-loop-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_434110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PE64"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="317" mass="34009" checksum="E7FC91501BDB1F1A" modified="2023-09-13" version="1">MNVTIAGHGQHLTTHEALSGVFGSVSLASWIFLLVPQLIENYRQSSADGISLAFLAVWFIGDVTNLAGALWAQLVPTVSALAVYFCFADLVLIAQCVYYNAKNARRAASKASTRSQDSVEQPLLARRDSSNVGLPGSHTRRRSSAASARERRRRASSLPSLVEEEDVRGTEWVKNAASIVGVCAVGAAGWAIAWKTGVWVPTPEHGASPSDPEPATPLGASILGYASAVCYLGARIPQIVKNQRERSCEGLSLLFFILSLLGNATYGAGILFHSLERDYFLTNLPWLIGSLGTIVEDVVIFIQFRVFGAGESSAVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEH5</accession>
    <name>A0A9P4PEH5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_366197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEH5"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2441569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="320" mass="36119" checksum="A9DECCC138221855" modified="2023-09-13" version="1">MLALASSALAQTRKLKWFGINESGAEFGEGTYPGTYGKHYIWYDYNTIDQFIAQGMNMFRLNFGMERLTPNTLTGAFDQYYLGNLTEQVNYITKKGAYAMIQPHNYGRFYSNIITDTAGFKTWWQNLAAKFKDNELVVFDTNNEYHDMDQTLVFNLNQAAIDGVRAAGATKQYITPEGNSWSGAWTWVSSGNGASLVNLEDPQNKLVYQMHQYLDTDGSGTHAECVSTTIFKERLQAATKWLKDNKKVGVIGEYAGGNNTQCITALQDGLKYLGENSDVWYGALWWAAGPWWADYMYNMEPSSGTAWKIVLPKIKSYFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFU7</accession>
    <name>A0A9P4PFU7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_487095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFU7"/>
    <dbReference type="OrthoDB" id="3761988at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2443142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="341" mass="38656" checksum="702DAC2B63DBF59F" modified="2023-09-13" version="1">MDPDTVSLHIADKDVFDEPENLKSVKLQADWTNEEEKRAKRKLDYNLMPLLVLRFFYLQLDRGNIANAITDTFMGDVGITQFQFNIGQQLLSSGIILFKIPSNMLLHKVGPGKWLTIQLFFFSIVGTFQAWQKNYSSYLATRFLLGMAESGYIPGGLWTLSTWYTRKETAKRVMVFFFDNQLGQACAKLIAYGTLRRHPQPPHLAAFKRTFSNPIIWIHFFITMANNGRGFDTYGPTIIKSFGFSWLSSNALASVGLFLQIPVNYAFSYMSDRHACGVFGEERVRIEVSAPRDVIRRNALDFGLWVIRVAPTDAAVVRVSQEVTGMACVRGVPDSKNEEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG51</accession>
    <name>A0A9P4PG51_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_495053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG51"/>
    <dbReference type="OrthoDB" id="4821062at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="205"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="538" mass="60225" checksum="C1303F5A05B353F6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGE7</accession>
    <name>A0A9P4PGE7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_474087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGE7"/>
    <dbReference type="OrthoDB" id="3727384at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040241862" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="60847" checksum="B7510D7CDC6764C6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGH1</accession>
    <name>A0A9P4PGH1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">60S ribosomal subunit assembly/export protein LOC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_39768</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient assembly and nuclear export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 66S pre-ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LOC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGH1"/>
    <dbReference type="OrthoDB" id="1743802at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037650">
        <property type="entry name" value="Loc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28028">
        <property type="entry name" value="60S RIBOSOMAL SUBUNIT ASSEMBLY/EXPORT PROTEIN LOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28028:SF1">
        <property type="entry name" value="60S RIBOSOMAL SUBUNIT ASSEMBLY_EXPORT PROTEIN LOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2443537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21468" checksum="DA900F95746DE6AD" modified="2023-09-13" version="1">MAPTKSVKGKPSKGGKSGGSKSGGPAKKPAKAGPAPEGISKKRQKSLALAKPGGVQKSKSKVTTGKRKKRVYKESELDLPKLNGIIPAGIAKPKGQKKGKTFVDDSASMMAIMSIVNAEKDKDVESKIMRARQLEEVREAKRKEMEARAEDKASKFEETKKGLKKKRKGKNSEPAKVDDLDDEPPKKTAKGKKKRVSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJ48</accession>
    <name>A0A9P4PJ48_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_455117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJ48"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="265" mass="29581" checksum="783CBA7EA37B9A35" modified="2023-09-13" version="1">MSTIASPRPSSSIRSPSSTRASFESSARPPSTTRRNRAALRDYYGLKAAKDNEAKISEESTRTELAHEDDETLTELDATDFDADAYVNNLLAKEGLKGVLRVEADLVSQIRNLDSDRKSLVYDNYSKLLSATSTIRRMRGNMDPLAPTTHTLGPAIAHIAETAASLSSSMQALPVRPQGLGIDIQVEGEDKSKAEAATKQKQKDTVLWVLDTPRRLQEMIDQEQDEEAEQEWEDMSKILDRWDVVPGVQELRQRCEAIMQEEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PJI8</accession>
    <name>A0A9P4PJI8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_454825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PJI8"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="107"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="268" mass="28995" checksum="41ACFC2CCA4554D8" modified="2023-09-13" version="1">MLASLRPDGALVCTPNHTHVALSKELLKGCVHGLCEKPISIDSESGQELIDCAEASGRHLLIGHHRRFNRFVVAAKNALPSLGKIVAVSGLWTIYKPPEYFEPPMEHPAHVVRASTEKTISQRGHPAEEGATITLKFANGIVGTFLLSDAAVSPHHFECGTGENPTITAEGRDAYRIFGSEGSLSFPDMTKWSYVGRKGWTERLNCEHVNVPEMKIPFELQVERFVAVIKGEEAPSCSGVDGLRAVTVCEAVKKSIADGCPVEISIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKI3</accession>
    <name>A0A9P4PKI3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_472644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKI3"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="44"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="504" mass="55371" checksum="B0B0853A5553A667" modified="2023-09-13" version="1">MKSDPLATGIFTLNLDQSERKIMWPAMNSLDSFPQYGFQHSQLGNLTGIARGSDVVQFRGIPFAEIPGRFRQARLLESLPQQPFDARRSGAYCPQPLLPFPLSWEGGIPADYPEFPEAPQDEFDCLNLSITVSRDALENSSVESLPVLFFIYGGAFIGGSQSTQVTGREIYDGTNLVRAAIARKQPIVVVTSNYRVGPLGFLASKELKAFNKAHGEPVGNYGLHDQRQALEWCNKFIAGFGASTNDTVALLQSIKVDDIVVPVSNDIAWPLIDGEWIPETTMEKISTMYKDGTAPDLMIGACEYQSGMTQELLTGDVREKFYNFASSNGMIVDPERFPDAYPSVTGLYKITSSLEKPSSAISGWADLMADIVFRITGFYIAAHHPANVLVYEIRGKNPYPPSLGQANHAVNDVFLFDVAPDLVPEDLQKAHAGNVAQIRAAWLDFCYGKLPWGSCHGGDDGLLSMHIFEHGETGRDAQTLEDAVGETLAQKWKGLFKAINAFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKP7</accession>
    <name>A0A9P4PKP7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_429816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKP7"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="560" mass="63892" checksum="9D7F6EA554D97F8F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLE5</accession>
    <name>A0A9P4PLE5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLE5"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="17580" checksum="FBA7755F401158CB" modified="2023-09-13" version="1">MWTLHGHKETAAFTKGVSRGWILSVCDRALCIYDFGYSFTQLYFGSIFSPTFLTAAANRVELGCTVPKTQQTRNKNVQSWVVGNVGCMIVVRGRGHETSPAGRRDMLDEILALDRTNSPTATEGIICERVSSQLGYSSHRNRVPGPNTSAIVDRFPHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMZ7</accession>
    <name>A0A9P4PMZ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_409181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMZ7"/>
    <dbReference type="OrthoDB" id="5401558at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="401" mass="43309" checksum="5DF56803C6026DFB" modified="2023-09-13" version="1">MFPHQGGQGQLPTHWQPPTSQQPAHGSYPPPPHMNPSLPPPPAHAPRDHRPDMAAHHHQPQQPYRLPGPGEWNQAAPQPDPYRAQQPPPGYMNQHHQPPAPRQRTAIACRYCRRRKIRCSGFEATDDGRCSNCMRFNQDCIFTPVSAQTQAFVPAHTVWRGVGQPPPMYGAYGQPLPPSQHGEAYAQQPRQQQPSAPPPPPNYLPSPTGPPSGPYQAHSAYGPPAPYDDASRDALNGRKRLHPEPHTPTLPPPRPGSAASLPAHRGAGPEYSYPEPPNAASPATSSASYSSAPPQQPYYAPQPPRRPSPPGAYPYEAGRASSSPHASQAPTTPGGTAFYPPPQTNGNLQPLPPRSDGTTPPPASQPANRPGMRINDLVSDNGNGRSSTDSNMLNMLNRRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNA7</accession>
    <name>A0A9P4PNA7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_250143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNA7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="99" mass="10683" checksum="2B17E7D3AFFEEF22" modified="2023-09-13" version="1">MTVNMELAALPPAAAHPAHGDTADHELPPAYSADHEPLPPTYQDASQHLKAPPTRNRWFRNRLLLAVVLTLVTAAIIASLAAVFTIQARKRNSESPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNM2</accession>
    <name>A0A9P4PNM2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_470201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNM2"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="469" mass="53716" checksum="5D222AD3B5A65634" modified="2023-09-13" version="1">MTDTIMSAKGKGKRAAEDEADDGKSVPIAAPAPAAHSTAPVSRLTAPQILRRHRHRRDNVAATVWGRCLPGSDAPQPFSVYKAILRHPNLFFQFAIRLPLNAIIDLYAIDKEFHYRFNKYSTSIIHDFASHHAPQAAYIFSWVLFPELCISDPMLRPMDGRPHLARDIPSLRWTRMVIYRDNVVRNILTILAVGGHRVPRETHTVLMKFWLLIEMDNSTLRAAFITDSTVWTDQDIYVFHLFLMKLDMHFNHPVYNHGFIDLSHMLLTQKTLSTLSKVLAGQQTMDYDDLTDMLIRTYHEEDLDLDAHPWLDDEGENGVVVDETGLLSREGWDLMGDRMCSPVDLVRIESIVRGLDVQAYLIDFMTYGYIDLDKKQNLPAPRRWRSEKKISLPKEPWPIPSVTAGLLATLDKRYDRNQEEGDLKNVSVHRAQRSVTVFMWDPSPKQDEQMEGIKNDTVENAGGEMEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNQ5</accession>
    <name>A0A9P4PNQ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_512373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNQ5"/>
    <dbReference type="OrthoDB" id="10622065at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="413" mass="47336" checksum="EC6EBC223F3E9A11" modified="2023-09-13" version="1">MELRGILFQIIRSISLVSWYLDSPHVARLGRHLANCPHNSLACLEAGQHALRTYQQNRAGWAECYRQQKLEEGRELRMRELKNDPYFNELFRNATEWKARGGTVPVVFNYFDNTTIIEFNNFCPNDMSPSLLLQKLKQDCDKLYGLSDLQLDAATKALLLADAQAEVSSLKGIPPVLSIDAPLLFSNHYERFVLFLARSGIDIDGIRGYSTRHPETFLLSTAVFVIGVFCIIRFLLWCLYKLFRFCKPSKVLQSNERAWSDQPNRRNKPAQDHRAQFQIPSPVRRPIQADQPLRRHQPETALSPRPKQAPRPSQPTHSEASDTVPASTTHIETSELEHLRKQASDTGGLTNATNLIADAVEGKSRKQGHPVRENNRDMVKRIQRNIGNEPDKEKNKEDEDDDEELWKDEEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PP22</accession>
    <name>A0A9P4PP22_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_217712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PP22"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="409" mass="46188" checksum="EB19DD3FA00BEF99" modified="2023-09-13" version="1">MDDLDDELDLRYHRRLKPDVYYRCPSSESLDGAIRNEFEKNAASLIPVDIVTEFVFGKTSTITVPVTQQPNLDALFEPADYPQSITVEYALCYGIEGKERLKLQRAIARCFIETIQAIDGFKYTERQAWNKDGSDGVRFKYVCLDSLQNRDRKSNAKKRTGSEDADSGNNQKKTNGSQLPTYDCGGAINVRFSTKREAVNVMYVHNLIHRDIESRPANYESQQPQDIPRIATTTNGTSTSAKPRKRKKSQNDHHVEADSAFQDADLNMSTSPEASKVSSKKKRKKDAARSEVSGSATREKSKSKQAKSPSRKARQKAPPRDPTPEPVQPVKGKCLRCREKGIKCNEARPTCNQCLRGLWTCQYEAHGPSKRSKNGCLNCRLRKRKCTEERPSCAYCLKVDDDCMYGEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPJ3</accession>
    <name>A0A9P4PPJ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Killer toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_471045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPJ3"/>
    <dbReference type="OrthoDB" id="4177994at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.10">
        <property type="entry name" value="Killer Toxin P4, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015131">
        <property type="entry name" value="Killer_tox_Kp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011329">
        <property type="entry name" value="Killer_tox_Kp4/SMK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09044">
        <property type="entry name" value="Kp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55221">
        <property type="entry name" value="Yeast killer toxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040424073" evidence="1">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Killer toxin Kp4" evidence="2">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2447885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="141" mass="15179" checksum="E29E240D24D2CDF1" modified="2023-09-13" version="1">MKLLIVLAFLFALSTQLGINCRGSFWAPICGRTINNENGPGGMYDFINENLSDAATFQDGQQIACMSCHAGKNEGLCVFTQNFGDQIVDGKQVKEAVLRLLKHGCVYHGSAPINPGNNVKDGQITVNYVTNGCVKHGAKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ04</accession>
    <name>A0A9P4PQ04_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_353706</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ04"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="155"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="411"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2448125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="517" mass="57551" checksum="D0D9E2A8EF5A055B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ39</accession>
    <name>A0A9P4PQ39_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_460591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ39"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34607" checksum="095B564C243E7292" modified="2023-09-13" version="1">MAPPATASKILPKSNFHNDFEHPDHVIPPRDYAGFENLVVVCCHAIFHPDASSSNFPIYSPHDEENWHLADFQKSNPDTGKPGEQETFLAHTLAGIDVLIGEWSPDVPKRTLLVMSGGPTKRSLTPLSEARSYYHAALAQELAQGNHGGGRAHQLFSRGRILLEEQATDSFQNLLFSILLFRRTTGRYPRQIRVITHAFKARRFLDLHARAIRWPSERILVQGIDPVMSGAEREQTIKGEEKHGITPWLDDPLGTGDVLASKRRNRGWDEQVAEQLVEGLEDSVKELIRGTVPERLPWQLAAVEDGVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ86</accession>
    <name>A0A9P4PQ86_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_212401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ86"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="137" mass="15709" checksum="1337E975A43DF705" modified="2023-09-13" version="1">MPRTRNSSHTPTKHRPLLPKRVKLVWLRLCPRVSWRNRHLHLVLSFDSGLTWTVGQAKATVGSRITMFRAPRSSIPYVTAATAKSGGRHTLLEQCPMFVADCGLAVCICLVPRLRDYKYILLRSLHFFPSMSRFLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQI9</accession>
    <name>A0A9P4PQI9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_518627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQI9"/>
    <dbReference type="OrthoDB" id="434144at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="7">
        <location>
            <begin position="85"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2447538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="726" mass="81474" checksum="3213D7E7C4A1D55D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQK0</accession>
    <name>A0A9P4PQK0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_430023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQK0"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="307"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="766" mass="83896" checksum="5271BED927954F26" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRQ9</accession>
    <name>A0A9P4PRQ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_223246</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRQ9"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2449040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="617" mass="67495" checksum="4D4A0D817869C9BF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRX5</accession>
    <name>A0A9P4PRX5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_441333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRX5"/>
    <dbReference type="OrthoDB" id="3695719at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="578" mass="65531" checksum="D7A4435E52998064" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS15</accession>
    <name>A0A9P4PS15_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_354948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS15"/>
    <dbReference type="OrthoDB" id="5428055at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="346" mass="39635" checksum="E4FC699B2012C103" modified="2023-09-13" version="1">MRIGCSVKDHRTIAGKRLRKSEILPLQQQSKDPDEICYHEAQISSICWGPDDSFWTEIFLVDTFFGSELYYEKYLDPVLDPGTNLVLRLDPPTLKHNLTLSSDPREYWLTQLDVRLTQVVHEYTALVGTFSKRMESYVRTPEFMSDRSGHTQTLSDVLETIQNFSDSISSTIDAWESFRRTQNSFFSPEARSNDANSIPTYSRLFNGIIQSIGELERLRSLLLTQRAKFKSRIENYVAFPLLFTAAIFSMDFVKPKSDNLAWGLFSTVFAVTSVLNGTIAWLLHKSLIQKAAGKLLASSQSFLRKLPALIQSLFSKALEWIGEFFAKLVPWIGRASNKLFEWWNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTJ1</accession>
    <name>A0A9P4PTJ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_482048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2449013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTJ1"/>
    <dbReference type="OrthoDB" id="10405363at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040462978" evidence="1">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="157" mass="16684" checksum="02EE47AB38D93031" modified="2023-09-13" version="1">MFSAQITTILATIAVTSFGQVNAGAITLSPRSLIPSWSCPGPNERQANFDIKTDDMQPPATAVQQNSLTSGHLDDQILIKASHGYLIKAGTVQVLAEPPWDTMKGDTGLKAIVTVGKAGDPCKGATDVSDYLSTAEFAFKTGKFFWDVFSPLITGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PTV7</accession>
    <name>A0A9P4PTV7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_428843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PTV7"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="237"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2448844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="431" mass="46879" checksum="93FA9853AA5959FF" modified="2023-09-13" version="1">MADTTPPSSEFELEDRGEQHPQQLPPVDGGKDAWLFLAASFVIEALVWGFPFSFGVFQDYYSTHEPFAGSGSIAVIGTCAMGIMYLDLIMVFSLLKMWPSYQRWATSGGLVVMCLALALSSLSNNTGELIVSQGVIYAIGGSFTYSPCILYMDEWFHKRKGLAYGIMWAGTGLAGVILPLVMEWMLRDYGFRTTLRVWAICLFVLTAPLLYFVKPRIPIAPKQRARKIDFSFLKTSTFTIHQACNTIEALGFFLPSIYLPTYARSIGAPGTLSALTVILFNVASVFGCVAMGSIVDKWHVTTCILISTIGTTLSVFMVWGFSMSLAPLYVFCLIYGFFAGSFTSAWPGIMRDVTKKRQTADPSIVFACLAAGRGIGNVASGPLSEVLIRGLPWKDSVGFAYGSGYGTLIVFTGVTALLGGSSILGKRVGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUG2</accession>
    <name>A0A9P4PUG2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_439085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUG2"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="215" mass="24441" checksum="80176F6DE54C64CD" modified="2023-09-13" version="1">MTSRHAAATSLGHNRMGWRVARKHRGVSRGDGDGDSVLPHRRTPPRRRRRGFNSSGHTDMKVAERTHVKPRDEVFAPGRGRADEPGEDAELGTSAGTYTHPGCHAIALAYDADEAQIEIDGRDRSYSFVWVGDREKGCMVTRTCWRTLIPLVVRYTVKCDVDVEKGSGQARKFGVDLYPEMGDLLWFTKEAEEWNESRGWRDGISGNEWHWELFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUH9</accession>
    <name>A0A9P4PUH9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_493023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUH9"/>
    <dbReference type="OrthoDB" id="10474189at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="258" mass="30098" checksum="37FED49E6883DA98" modified="2023-09-13" version="1">MQSIPCQPSTVPHSKPITNTEAFEFLRVEYATMQSGLARLDQRLDEVHIRSQRTRSGLRTALQNNVELTQEILSAEVDLSLANIRIHDLLYHNDILEKESIHHVAEVATTHERLHTLEFQAHAQADEHACLRRSRANLRETLRLVTKEIDDALEQVTTLEFRMGKKDRDHVFEINRLRRRAKERDVIVEGLRAQIKEYKWRVEEVRRENKVLRKALERKRKRVGNAPGSTKYHIHKATKRSPGKRIDGSPYSCQQILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUK1</accession>
    <name>A0A9P4PUK1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_426858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUK1"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="336" mass="36076" checksum="78E728FF36BB1768" modified="2023-09-13" version="1">MKGIQIKEYVNGPDDLKVTSLPTPTPKPNEYLIAIHASATNFFDLLQIRGKYQHQPPFPWVAGSEFSGTVVSAPSASSAPKYKPGDKVFGATQGGYATHVACTEERLRPVPRGWSFQDAAGVFVTAPTSYAGLVVRAGIKEGDWVLVHAAAGGVGLAAVQIAKAFGAKVIATAGTQHKLDVAKSFGADYAVDYKQKDWPDQVKKLTPKGRGVDIVYDPVGLIAQSMKCTAWNGRLLVVGFAAGDIEKLATNRVLLKNVSVVGLHWGMYAVNEPEMVEKVWDGLFKLMDEGKYKGTVFSDQEYVGLESVPAALKALGGRESWGKVVVKVPQEGQSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUL0</accession>
    <name>A0A9P4PUL0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_426870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUL0"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF2">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040299167" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="49"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="358" mass="38934" checksum="0E3C683B480C3FAA" modified="2023-09-13" version="1">MQFTLLALTLALAAQDVSAAAANALMARQFAQAAMMRFQCSQLVYDRIDPLVQPGLLPSTHMHQIVGGNSFNATMTPVSYDPAAASTCTTCDYAEDFSNYWTANLYFRAANGTYKRVPQMVNLGLQGREGVTVYYIPPYDGKSKVTAFPKGFRMLVGDAGLRQKQGQQKQLCHRCFSNKKQDPFGGAPCTGDDTYDLPKKQCGGGIRTTITFPTCWDGKNLDSPNHKEHVAYPTSGSFESGGPCPSTHPVKLPQLMYEVMWDTTVFNDKSLWPTDGSQPFVYSMGDGTGYGQHGDYLFGWKDGVLQKALDARCSGNACKTLKTQTSAVSTKCAKAQSVHEDAEGWLTELPGAPAVTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUS4</accession>
    <name>A0A9P4PUS4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_348946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUS4"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="114" mass="12781" checksum="082F7ACFCF359205" modified="2023-09-13" version="1">MTSSQSPPPGAADRPRLTEAQKKENHIRSEQKRREAIRDGFDRLASIVPGMDGQGRSEAVVLEATLQHIREQINERQKLVEAAKAKGIDTTGWELSRETVTACESQQKRNESEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUW6</accession>
    <name>A0A9P4PUW6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_503696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUW6"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="269"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2450886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="459" mass="51965" checksum="EA916AFC159C7F18" modified="2023-09-13" version="1">MVLETLAVVGLVGNIFQFIDFASKLFITAVKVYQSQDGATCEAETDKDIARSLQQSCTDLEMGIDGIRRNELAMQTTRTSLVTLAANCKTAAEEMIIALDSVRSNKPGSKWKSLKAALVTTLKEKEVDAMRRSLDTYRSQLALELQMLQGAKLCRGAWKDVIDRLEDGNKHIARQLGIYFVEIISEIKIAQEQLKQQYESIVSQEVVTPVIPAKPEGFQEATLLRSPGLVPMVQKEAIDLCSDMAVLNSLRFDQMGFRHSKIPEAHPETFSWMFSKHFEPWLTIPEKIYWVSGKPGSGKSTLIKYLADNERTSISLCHWSGPKTRLVITSYFFWINGSELQRSQQGLLRTLLFEILQQCPALIKPVALEVWKDVQNTITSRSVDYQIVWSQKMLLGAFEQLSTLDQVDTAFCMFIDGLDEYKGNHGDLIKTISFLERRNVKMCIASRPWNIFKDAYGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PUZ8</accession>
    <name>A0A9P4PUZ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_348058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PUZ8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43036:SF2">
        <property type="entry name" value="OS04G0481300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43036">
        <property type="entry name" value="OSJNBB0011N17.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31149" checksum="5C2F5F4A26B94EB8" modified="2023-09-13" version="1">MLSNNAPSPPSADPTLSSHVRKYVPQLQSWPYTPKDFSRSDETNDDDFYDQPRYVAHIDEQAIVRLTAYFGIVIPRKGRVLDFCTSWHSWYPETHIEAAKSNELEVYGIGMNKPELDRNSLLNNHPTRSVVADLNVNPDVRAQLSKGGAEPPRLDAATCTVSIDYLVQPVEVLRSLRECTVEGGKVHLVISNRCFPTKAVRMWLELDTEERLQLVGDYLHFAGWKDIEIVDLCARDRDGTRLTDENGRMLQGEGMLGFLRLQHMDPLWVVRGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV48</accession>
    <name>A0A9P4PV48_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_439546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2451006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV48"/>
    <dbReference type="OrthoDB" id="3786836at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040510816" evidence="2">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2451006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="350" mass="35661" checksum="3A8941F2678E226F" modified="2023-09-13" version="1">MSHITGFSSLAVATLLLQSVRAADCNLAQPRRSGDPPGADIASDLRGQDNALLQSVCNGGFPPGSDTISTWNTGSQIYNATRTDNSQPLQYCFDALDNIITQCIENDNYWGGDWKLGNEIYAIYDSTWPEHVLQAELESPSSSSAQEAPSSPAPEAPAGATVVTTTIDGSPITQTFVPTTIADASPTTSSTTVDGVVVPLIIGAGGVAWVPFVPAGGAPPAVITPPADLPNGGDGDGDNNPQSSSQDSSSSSSSSTSSRSLRAPDDVFPADAGTATFDSGAAAQIVFFGAAAPTPTSSSSSVAPSEPTTDLFAEAKKLCHERCASHPGLTTPDGQWCLGNCGCFLGAAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV55</accession>
    <name>A0A9P4PV55_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_351883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV55"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="557"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="606" mass="67901" checksum="974939A8FC26E023" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PVX7</accession>
    <name>A0A9P4PVX7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_346221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PVX7"/>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000004">
        <property type="entry name" value="Xylanolytic transcriptional activator XlnR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2451212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="945" mass="104162" checksum="28A44A98E39F12D2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWB5</accession>
    <name>A0A9P4PWB5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_352076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EFG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWB5"/>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2449981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="283" mass="32590" checksum="2EDAFFB6CAD73CA5" modified="2023-09-13" version="1">MKRKRSDNADAGDHGRRHKQYRQFSNRPRPNQNPGSRRPHARSGYAKPGDEEEEEAQKSINALKGRIRDLRRSLAHVDSDPKNRMPQGIRIERDRELESCRHELEEKETAKREAKFRNDIIGKYHMVRFFERQKATRIVKRLHKQPAALEDESEKAEKTRSIHNAEVDLNYTLYYPLLKAYVSLYPKQQKEDSKSGDAVPPKDGPKGDVDMWKTVEKAMEEQTLEELRESREGVTIPGAPESSKAKNMKNDGKKDMKEKKAKSNGADAAMDNGDEGSDEDFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PYX8</accession>
    <name>A0A9P4PYX8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_515798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PYX8"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2451873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="549" mass="61746" checksum="E55B13D2651DC6B5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U500</accession>
    <name>A0A9P4U500_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_478181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U500"/>
    <dbReference type="OrthoDB" id="10636724at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040255990" evidence="2">
        <location>
            <begin position="31"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="245" mass="26445" checksum="C5CDF55881DC4353" modified="2023-09-13" version="1">MQRHRILYYMLGLLATQFILVGSLVVPAQSDICNPSLQLCLNRTITDEFRTIQVIDLDRRAGGGGGKGGKGKDPEPVPGSGSSGGGDTPSTPGGSTGNGGFETEETAGGFETAETEGGFGQPTPDKEPEPVPPAAPAPDTEPQPGRSNPADDERVVVVQDSRALATLERWKCGKTKRTSLFHRLSRRAFTSADATDPEKYLEWLENMATDDNKNRFPRDKLVFFTTFYNKGTKIIANKFIEANPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U523</accession>
    <name>A0A9P4U523_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_491232</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U523"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2438574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="280" mass="30899" checksum="606BAB80E07DA004" modified="2023-09-13" version="1">MAGIPQSIFRWAVPGAIAISFAQASLYDVKGGTRAVIFDRVSGVKEQVVNEGTHFLVPWLQKAIVYDVRTRPRNISTTTGSKDLQMVTLTLRVLHRPEVKMLPKIYQNLGLDYDERVLPSIGNEVLKAIVAQFDAAELITQREAVSNRIRNDLLKRAGEFNIALEDVSITHMTFGKEFTRAVEEKQIAQQEAERARFIVEKAEQERQANVIRAEGEAEAADTISKAVAKSGDGLIMIRRIETQKDIAQLLARNPNISYLPNGGAGGEGKSGGSFLLGLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5M8</accession>
    <name>A0A9P4U5M8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_437260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5M8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="72" mass="8254" checksum="6C485B16B7F2F356" modified="2023-09-13" version="1">MYGSDTTPSTVWSLIISIWFPWYWTIGIWYQKTFASLSQPESTAQKPNQSCEATHPTFHGLEWLSAVEKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U753</accession>
    <name>A0A9P4U753_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_447819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U753"/>
    <dbReference type="OrthoDB" id="3923202at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="151" mass="15570" checksum="0C8987E69EF624F5" modified="2023-09-13" version="1">MATAAACPVIGSTNDVLPPNHPEVDLTQDGQTCPVVGATTDHHHNLHKHPSVPISEPKSPLATQCPALKSAVQEPKSQAMDDAICPVVGTATTILPPDHPDTTQAQEGDVCPVTKASVGHHRDTVHTHPSLQAASDVAVCPVTGQHGPAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U832</accession>
    <name>A0A9P4U832_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">P171DRAFT_447420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U832"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2440466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="332" mass="36405" checksum="7877F0AE4828199D" modified="2023-09-13" version="1">MDDPRISAAGAGEYLVGGLVCDRAMRGAALLPARLKWSMSVAPISCCRPEYGKTPMDARSRTVVALRRRTTVVVPTLRQGSTTDEHMRAGPRSLTPRQCLGILHRSIRKWRSRTDPKRRGQDMTGRLEQQRARTAGGRSPGEVDPFANAHMEAIQKLPIARIMTRSTAPPVNAPPRPPPEPAYESTPMTSERALRQLSVFAFGAASFLVATAITRRAVYKRHLRTKPTFYAPNTNPHEHFSPLHDAAQALNLATMHCVSLATMGLGGTMWAFDIANLEEARARLRGRLNYDTIYQPGEAVPDSIMDLLVAAQATANTEGGENSSSDNPEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8Q4</accession>
    <name>A0A9P4U8Q4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_98168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8Q4"/>
    <dbReference type="OrthoDB" id="3795887at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF33">
        <property type="entry name" value="MEMBRANE PROTEIN WSC4, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040165338" evidence="7">
        <location>
            <begin position="20"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2440287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="369" mass="39485" checksum="4BB23D3760A9ABDF" modified="2023-09-13" version="1">MFNLLPFALLLEVFAHVGASPVDATLEAAHPMITQRAELFVREAPLSFIGYYYASTDSEGNSFIRSSEKSGSVATFRGSTLVDWCLDSPYYLSATCPTAYWTACSGSSTLLSAGGSAACPESSTCDYDIIYTGSEIDTASSLRWYHCMDRTYLRFYREVPPGTLIEDATSTDSTSTETSSETSSDSFSAETTASPASTGTSLASQTSDPTSSPTPTPSTEPAKEKEPSKAWIAGVVIGILGLLAVAGMGFYLWRQRNTHAYGPTPQGPPQTHVQPEYPPQQTAYYPPQQTHGNGPIPYLQPMSPNMGAYDAQTAKPQDNTMYGGYGAQHYGAPPPGVGTVQMPPSSPQVHPQLAVNVHELPELAPSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8S3</accession>
    <name>A0A9P4U8S3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_434094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8S3"/>
    <dbReference type="OrthoDB" id="3223416at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040467059" description="Small secreted protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="19788" checksum="6F9B5FFC15E84F04" modified="2023-09-13" version="1">MVARTRTTPTPLFQVVAFLFQFTFLAAFALAQNTTHLNITAIGAAGGRSTIECWQITRPFDISADPGTAGTKAQQLGDTTNLTFTILPPKFDGGLHHAPAVQYVAFTSGLAVVTLPDSEDKATIHGGKYGLIIAADIASVSKKGHVTRYPSGSTTTALQIRMKDNTPPAHTILHKGACRREELVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8T3</accession>
    <name>A0A9P4U8T3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_366977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8T3"/>
    <dbReference type="OrthoDB" id="5357075at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="319" mass="35902" checksum="CBE86881AD094668" modified="2023-09-13" version="1">MQPLLVHFCNLCSTSTTIPFSASVFSQNNSCSHCGAISTGININTRGKQQDPNMQQDELAQLFSAHMRLSQNSHHASQIPQAVPQEQLAQQQEQVSQPIIYASQHYTHSHHVAPSRQVDQEPAKTHIEPSELHAVFLRNSIDPSLLFPSQIDLFQNADNDQRLRLLELWRISPPSGSTARQLYDWPPTSLAQEETMAKLRYEKMLDQSMNQSIDTAAVQAARDIRVGSPDNAAEPYIVSGYDMLARREYEESAKPAGNQLRESTSYNQATDPVYMHAGQTSLWEKNVGSILDMENQYGAFAHARDFDVHRTYGDDEMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8X7</accession>
    <name>A0A9P4U8X7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_447447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8X7"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="199"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="297" mass="32322" checksum="18AD482F15FADABF" modified="2023-09-13" version="1">MSFSVSRNDADGDYLLVVSGQLRKDPYLADWKAFKDHIRKVVREQPGWSNVCEGNIRGDMQGWCRLKHKEDANSVYSAYSKQVVIHIFATSLRTGYWDLLKCNCNRHFGVGERGHSPGRSGIDVNAVNQVFGKRESASAAYYAVPGQPSYQYNGYYQATPYAPPAAYPYPGTPMQPVYSQSSGGLPVNVSRGAVITETRGIFLQGLNYSVGNSELATLLNSAGLRPEQANVHKDSRGASKGVATARFSTKAEAEYAVSKLNGTGHAGKTLTVRMDTNSTVIGSLEPFVVDGSNKSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9D0</accession>
    <name>A0A9P4U9D0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_35208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9D0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="80" mass="9409" checksum="1571F085DD80C94F" modified="2023-09-13" version="1">MSAFRLRLSLILSFFVVFHPKIIHAVRFWFGRSSVSFGIQSRKMGHMSGIFTVRSNRTRPCRHGPRCQFDSPLSRDHWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9V3</accession>
    <name>A0A9P4U9V3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N1221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_415579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9V3"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="127"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="564"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2443824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114907" checksum="26C4D238B70C1FA9" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAI5</accession>
    <name>A0A9P4UAI5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_322009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAI5"/>
    <dbReference type="OrthoDB" id="3924764at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="90" mass="9473" checksum="539AFF527400E3BF" modified="2023-09-13" version="1" fragment="single">CTLSVCADYINSCGRWYGGCYAVCPGYTTPRFTDPGCPTTSSRASVIVPEVCSTTLCADYINDCGIMYGGCFLDCPGHTTPSFTDPGCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAL4</accession>
    <name>A0A9P4UAL4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_433754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAL4"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2442207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="224" mass="24588" checksum="3711DFDB2500027E" modified="2023-09-13" version="1">MSATTKIAVHSLSDLKNTTDDALPNYLHSLKFKQIHKQTDVRLVIGYSAVIIAGALFYYDWKFGWEASKPYTLPAVVAYFILNTAFSYWLWFVEAGTVYEGEGKTGKVRIASSTKKHIPIYEVDVTFSPAGSSHPQKIHIRAPFTRWFTSDGYFIAKPFQQWLASEVPVVGAADPNNVVEEIGRGSGAENVVNASGNQSAIDILQQLKASGANVSAGSGRRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAX9</accession>
    <name>A0A9P4UAX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_69206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAX9"/>
    <dbReference type="OrthoDB" id="4156665at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="192" mass="22452" checksum="FCF145277822386F" modified="2023-09-13" version="1">MKHPRHHPSQPPNKPKNKKPPAITLAHRRAMALFQRNPVLAQKLCQMRLKIAPIVNVTTGLPPSPFPTTLLSLFLLTEPELDAMAAYYSQTIPNPSPTSLTFAYPQTMDWNRELLRNEPGMLPEEKLSDVERLKVKMRMFARFIGMRGAETPRWEYERGVEILARRIERRVRWEEELEMRRKVFMGPRAWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBS2</accession>
    <name>A0A9P4UBS2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_37028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBS2"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="169" mass="19027" checksum="2F447613766C823F" modified="2023-09-13" version="1">MAGAAGLAIGVAALFNTCIDSFKIIFAAQDFARDFEVLNTQFQQQKLRLLVWGQSVRIVSRQGAIPRPYPRELNVDHVKPMVFRSSGSINSLLERFKVLEGRYGLKDHAMAGLVHVSVLRSAAPKEMIDRNQNKKGPKALGKWAVFDADQMRYTNKQLKSLIRHSFRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UC68</accession>
    <name>A0A9P4UC68_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_44463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UC68"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2443812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="419" mass="48434" checksum="7F38037ED7C6C074" modified="2023-09-13" version="1">MWFMNILRTIWGDKDEADKPLQERYDDLLRSHKDTLTKYVRLLTERNARYAAESESKAAPSLSTKQADSKSKSASATDKNGVENKRLQKELEDQRRQNEHLRMQLQANQEAEESGVNIQAHENQRLETTVKNLQARLADYTKRDITHVELIKQMLRSSEERQRQLQATSDQGLAAEEKKTADQLAEARYQLASVKADVDKQKSKLTNLEADIVHLEAYQPVLVGKKNLNSAEEMKVQSARKQGYQDAVRDYREKSHSLEQKRQKLDNEVKLFESDPVKVLKSCMTHFFVNSNPSGASEDDLEAAAHDGFCHGYAEAYKVRDEIRCMVFDPDDIDNPVHPFNRAVMVARHAVPILLSQKKFPYTDYWDTRKFKSEWTDNEILMPRIPAPSHEYNYWFGIRKVMTELDYFSDMAPDDGPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCI1</accession>
    <name>A0A9P4UCI1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_432432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCI1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2444383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="203" mass="23727" checksum="885D3266285160F0" modified="2023-09-13" version="1">MSLMLWFRLVESLRLVGRYTFGDTKHPIDLIYDARLNELASRQESDVIWRSISDGLLPMQTRREVVEPRSKDDEASPEEMTKAMQKLHKAELEACRAECAAALDAKDKALEVALEAKDEAHKADLRVREARKVNFQDTMLKELMFLLEYNDQAMKVLRDCRDENFRRSVQAKKLRENIPLAISEWKRRTGTVWKSSNWNAERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCV8</accession>
    <name>A0A9P4UCV8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_358748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCV8"/>
    <dbReference type="OrthoDB" id="2530523at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="288" mass="31697" checksum="DF5C72EA012C9918" modified="2023-09-13" version="1" fragment="single">LQQQQQQQQQQQGQASPYSSAPFAQALASPAHQQFVQNRQTASPATSQHTNTASPYATPQQTQSPSVPATQGMNPPTSQPTAAQPMASQTPVKALPQSPVSPVSQAREKQRIDTLLEINQVLIQQVMELYEQGKAGHIGPAPDAKQEGEKPQQPSPEYRDYMRRLQANLAFLAQNAEKHTKPNQNIMPGPAIMVAPSSPDELVKLYSRLQSLFPGWKGAPNKPSPGPQRLNSTSSQTAVQNSMQPPNSAGLHNNMQLPSNAMPNNFQQQQQQQQQQQQQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCZ9</accession>
    <name>A0A9P4UCZ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_484964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCZ9"/>
    <dbReference type="OrthoDB" id="5375886at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="75" mass="7882" checksum="C56FF350332045B4" modified="2023-09-13" version="1">MKKIKMSAPNGGRQSPEPEQQSGAQQSDAPASNVNDQGGAPSEGTKQANDDQKADLQSNPTHPLAKHAEETTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD49</accession>
    <name>A0A9P4UD49_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_443787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD49"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2444817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="542" mass="59983" checksum="E9AC254F50A8682C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDS3</accession>
    <name>A0A9P4UDS3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic translation initiation factor-like protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_428264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDS3"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="264"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="432" mass="47980" checksum="13543287F7100AC8" modified="2023-09-13" version="1">MATINVRRDVTDPFYRYKMERIQSKIEGKGNGIKTVIVNLTSVANSLDRPPAYLIKYFGFELGAQTNTNPADDRWIINGAHDASKLQDYLDGFISKFVLCKKCKNPETVMEVKNGGITEDCKACGQISQVDLRLKLSGFILKNEPKKGKKDKATKKAERRARKAAGKGGDDDENASQNGSPGDSASDRGDENGDYGVAAGSDDELTRQIEDGALDIDDVPEEKEVQWATDFSADAVKSRAEILPEDLKRAAINPAEFAEELEDGEGGSSVYDEFGKWILDTAAEKGSVDKVDSVEVYVKAKELGIESKHRTLTVLAQTIFDKNIVKQVDGRAGMLKKMITSEKHEKAFLGGTERFVGIDHPELIPQVSAILIKYYENDLIEEEQLKAWGSKASKKYVDIKTSKQVRRSAEKFIEWLDQAESDEEEEEDDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEQ5</accession>
    <name>A0A9P4UEQ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEQ5"/>
    <dbReference type="OrthoDB" id="5418867at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="172" mass="18730" checksum="7F36F60EE5859EC0" modified="2023-09-13" version="1">MVNWTPEKHQILLKEIFQYCDIKMNKELCQHLANVIGEGCTPKAVQNILSNLKNHGRAAGAERTATPSRATPAKPKSALAKSSPAKFTPAKTPSSGGGHGRPKKQIKADGEPTNDLGDHSSPSVGRKRSHTAEATNGTNKKIKTEQVYEDNIFQHEDFFPTAEEDEAAQTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFK7</accession>
    <name>A0A9P4UFK7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_352634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFK7"/>
    <dbReference type="OrthoDB" id="5426798at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="923" mass="102715" checksum="32C6D84ED0546C6F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFV2</accession>
    <name>A0A9P4UFV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_481965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFV2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="256" mass="29756" checksum="2A2069908F2B80D4" modified="2023-09-13" version="1">MAGVFDFDQYHQSIKEHRRGYRHRAARNTACVPEHDLIKHIGFQQDIMHAAAAELTQIAEPCSTRAHRRPVEMQKHLIDRKEKLNKEAHHRTEEKEYEVNEQAEQTADKGTVKNGDYGCASYVTLFMLGVPLHPNTPLLLLLTLDLDRIIEQPLYQYQFHSLQLYQLNMPNSTAQLGTSADIHKRFWRELANRYLGKEVCQLCLSIGHQAVECPYVCDICVDPNTFPSMRVREAQLEEDRKRRELYENNKCSVSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFZ5</accession>
    <name>A0A9P4UFZ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFZ5"/>
    <dbReference type="OrthoDB" id="5344687at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089:SF1">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="199" mass="21378" checksum="CB6EC2D139675611" modified="2023-09-13" version="1">MHDEHPHPLLAQVPLTVSPFVSLPTATPLPYTYKQLPSTLPPSVLSSNATSDPTQPQSQSQPQPPPAYVVSSSGTTATPDQILSSCLALQSHLQNLENEARSTLKAWEDKRKAEDLAEKRRVAPGWLDGDVKLLRPENVGSGDAEMGEASAHGQGQAEQGSHQRTTSVGIKALMERRDGVPDPSEGEELDRAFGGMDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG16</accession>
    <name>A0A9P4UG16_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carboxypeptidase S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_439689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG16"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040267901" evidence="7">
        <location>
            <begin position="20"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2449106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="590" mass="64734" checksum="D6496B05617F9052" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH68</accession>
    <name>A0A9P4UH68_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_509380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH68"/>
    <dbReference type="OrthoDB" id="10539271at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="223"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="381"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2448972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="449" mass="49146" checksum="781868F303489C87" modified="2023-09-13" version="1">MANLQNSSLVLMSDMPPGTEPAWIHKHVIYGEAEEIEMARDGFYVHLPTPADAQDFARRYDGSSHGGKSHVYKKHISVKVIPMTEAPEAADVQLRLTDFLRTEAAMPHTKTVHISGLPENNAKRAVMAMCDEVFDCWNISDDPALGAVTKDLNPGYPHIEMDNSTYYPEALVRFTSKEAAAAVVSQHNGGYWNNSTTYAEFVDDAELDTIIQAKKESGGKTAKLFIGAVKPNASKETIRALFAPHQPTDIIMQPGKRFALVFMHQDAAAKFLSDFPPHKGKWHDGWNYRVKRAEDKSSARKKSTPALPDSSFQTTPASGPLSNDGKDVAYGAFKNSTSGSDTGYVGPLSNNTYSASPSWASPDVRTSAVNGVLVPQVSTSEVRISNLAPHANEEHVRKFFAACNVSTHNIVLSKDDHEALVSIGKDDVEAALLMTNKKFLRRFVTVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHH1</accession>
    <name>A0A9P4UHH1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Glycoside hydrolase family 31 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_402257</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHH1"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040178498" evidence="15">
        <location>
            <begin position="21"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="17">
        <location>
            <begin position="79"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="16">
        <location>
            <begin position="266"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="18">
        <location>
            <begin position="646"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2452179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="842" mass="94836" checksum="5C073ED543A8AD15" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHL4</accession>
    <name>A0A9P4UHL4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_460880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHL4"/>
    <dbReference type="OrthoDB" id="3556572at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="62200" checksum="4674AE3F594CBA66" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHZ0</accession>
    <name>A0A9P4UHZ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_480819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHZ0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="141" mass="15000" checksum="9988D48D1EED5B34" modified="2023-09-13" version="1">MAYWSLVGAKPPLSTFVSSLGLAACEDPRPCLPTPTAATAATAATAAHQPDQATMASPMGTQCVPGGTRRYSALGTAPSWGIRRLHLRRRSLLLLPWSPALHLRLPLAWGRALEAFHAMAAPSILENSVACTAPLQRAWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIA2</accession>
    <name>A0A9P4UIA2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_425991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIA2"/>
    <dbReference type="OrthoDB" id="3790619at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="76" mass="8252" checksum="41F44AA48F716696" modified="2023-09-13" version="1">MSPPQTEYVYIPNLIGGQMLRIPVFSLEADYEEEEDVTIPSPSDLTIDTSALPIPARDASPTPSVDSTVESVEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIA5</accession>
    <name>A0A9P4UIA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ent-kaurene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_452070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2450097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIA5"/>
    <dbReference type="OrthoDB" id="2343925at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739:SF25">
        <property type="entry name" value="(E,E)-GERANYLLINALOOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="995" mass="111321" checksum="AFD751F980A60345" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UID3</accession>
    <name>A0A9P4UID3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING/U-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_439151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UID3"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2450518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="178" mass="19824" checksum="69F6F619A539765A" modified="2023-09-13" version="1">MSSLSTLEQFVTEARAIGMDLDAPIEDTTTPIEELRNTLEELRDTFESISAPAAVRAPTLPRTKQISLEQLEAASKYLTSAPEDNECAICITELVAADNKAEDNLETSHQTSTAIRLDTCGHVFHSGCILEWMKESNTCPFCRRKVCEEHTKEMEGRGSPIGWSDEEDFWAAGLLWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIH7</accession>
    <name>A0A9P4UIH7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLP1</name>
        <name evidence="14" type="ORF">P171DRAFT_515264</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIH7"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="12">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="133"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="11">
        <location>
            <begin position="343"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="136"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2451205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="462" mass="49297" checksum="A3417DC382EC100A" modified="2023-09-13" version="1">MIALPGLNLGAQAPEPLNVPTTSATRTQELSANTEYRFEVSFARSLTVKLLTGTAEYFGTELAPATTYTFSGAKGAVFTWHGCKLEVGGEAESEYVAEETQMMSAANAHFALEALRERALQTRDAGPRVLVVGPENAGKTSLVKTLTAYAVKSGQQPTVVNLDPRQGMLSVPGSFTAAAFSSILDIEEGWGSSPISGPSPTPVKMPLVYHYGLRDAEEGKVFRPLVTRMALAVTSRLEEDPASKTAGFIIDTPGAVAQGRAGVYENIEHIISEFSVTTIFVLGSERLYSDLSRKYSSPNQPDAIRTVRLDKSGGCVDRTDAYMKALRHAQIRAYFFGNADAGLAPHSQSAGFDELSIFRVAEGTGMDFNDGGDAYGGAREDAIYERVTPSSDIVNKLLAITTAPPSDAHASIRDASVRGYMYVAEVDEAKKRVKLLAPQPGQVPGTAVVCGSWPEDVPSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIU3</accession>
    <name>A0A9P4UIU3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_7734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIU3"/>
    <dbReference type="OrthoDB" id="3760562at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="478" mass="55313" checksum="4D875099BF4ED097" modified="2023-09-13" version="1">MTWQFITNDIGPKERRLIRSHVMTGKNAGRPRPSHRKKRDAATQQITSQHAVTHKQDRMVPQRRTQDLQRSNLFDRLVCNDLAFAEIPQQSTKSIELLRQWLSLIDRRLYPPEFCSRLDFMDYVWLQYVFYDEGYMHGVLAIKASFRNYLETAKASPDALEHLSRAYKLTQRRLAGPEAISDKAIAGVTILAIYQLVHGNVDIGLVHFDGLCRMVGMRGGLAKLMEHNRALAQKPWRIDLEFALQSGLPMRFGGAEVPLPATKTMNPRFISPTYTKLCDYGIDIELVCMLSDTTAFTNSLNTINELSRLDPLDFSEQAFQLIHRLIDFASLQGKRPIHPLEDLLQVTLLAIMTTSLPNYTTDQLHYELLANHMKRAIMRYVATTDRDSKLLLWAIFVGRVSILHHDQDDWIGRILLQASQQAQIHEWAQIQRILSRYCWIHTLHDTVAMRIWEKFNEKRAEEERRLRVPFRAQISGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJ22</accession>
    <name>A0A9P4UJ22_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_401517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJ22"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2451760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="575" mass="65868" checksum="FFACEBC6727D1298" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UJQ4</accession>
    <name>A0A9P4UJQ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carbohydrate esterase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_493584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UJQ4"/>
    <dbReference type="OrthoDB" id="2128708at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040516372" evidence="8">
        <location>
            <begin position="21"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="568"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2451943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="771" mass="82973" checksum="C3A6873783417F63" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P3B5</accession>
    <name>A0A9P4P3B5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_491886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P3B5"/>
    <dbReference type="OrthoDB" id="3729042at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="162" mass="17355" checksum="FBCF41253AB39B5E" modified="2023-09-13" version="1">MVLPAGMNLYLFKKAKDDWRTLNAYMKEKGATVRKRDVARGIGRALVEKAMLVPITLGHDDFLLAMPQGSMTTALAGHQALLEVPGIGEANKLIQAPVEIFQQDHHILTSDERLEAISRGMVDMGGWDAPAKDIAANVGIAGTIAAATEAATTVNPHPNSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4G0</accession>
    <name>A0A9P4P4G0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF566 multi-domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_372236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4G0"/>
    <dbReference type="OrthoDB" id="2561686at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11124" checksum="B3C4A213D178C528" modified="2023-09-13" version="1">MSSIIHGLSDLAKSLVEVVWSLFTTAGDLVQKTVEFVLRFFTGAINLVIEFFQGLVDLAGGIVQFVLGNIAMLAILGLAFFGFLQYQRSQGRSVQVGNKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4U4</accession>
    <name>A0A9P4P4U4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF618-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_436882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4U4"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17003">
        <property type="entry name" value="CID_Rtt103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="432" mass="46642" checksum="FA50DB6176C93D04" modified="2023-09-13" version="1">MAFTEDSLKAKLSSLNETQDSISSVGQWILFHRRHADKIAALWSQRVKESAPNKKLTLIYLANEIVQQSKIRKKEEFLRAFDPIIVGGSTQAYKGSPPDIQSKMRRVFEVWKSRQVFRPQIQEELERGLDDIDRTRSSKKPLGQLGGSLFSGSSIPPDLKPVEPLATALQKADLATKPLLTTANQGYEKITKPNAPIPTPPIHAAALGTLVRDLAKAENAVADSIKARQALVSGLEKLLETNRTKLTEEATTVTEIKARKATMETRMREVEAAIMSGLAETSNGSSAQITSFAQSSHERPDVEALTPPPVESFTPVGSPTLLAQQTPLPDVPDDVFPEMPAHPVEAPMAAAPAGTNVANSEPATAIGAVNTIPGADLLHSLAHARPAEENGVYGQATYKKRKMSRSAAEDEFAAFEGDTAMNGIDSTLGDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P532</accession>
    <name>A0A9P4P532_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_425154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P532"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="197" mass="22148" checksum="2C48F28040B9FDE3" modified="2023-09-13" version="1">MIPYLDASGNDVGFNADKGVCPPFHPSLFPLTPDHYLITLIQYNTLRGVLTNLLLVQVHLNPECQNALRIPLLHAPPDTPPPTFRRTPIQQSVDHEDWIDSVPCPTLRDNLILASSPSTFDQDEMCDDLCGGLYDGFDHVESRGLLVWSEPWLVSSWEISPGFAKKWAFLLKGCGEMVRATNAWRERRGEEPLVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5D6</accession>
    <name>A0A9P4P5D6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_505387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5D6"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2437746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="544" mass="60821" checksum="821B39DED7A0B5E2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5R0</accession>
    <name>A0A9P4P5R0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3494 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_345372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ice-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5R0"/>
    <dbReference type="OrthoDB" id="10264374at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021884">
        <property type="entry name" value="Ice-bd_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11999">
        <property type="entry name" value="Ice_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="19354" checksum="196FC29F940A95E3" modified="2023-09-13" version="1" fragment="single">LGTASQYGLIANTAITNTGNTVINGLIGIYPNDINSVTGFPPGTSGTINAGNDAANLAVQDAQAAYNTAAGLTPTAAIPADTGNQIFTPGVYNADADVTMTGTTVLDGQNDPNSLFVFQIPGNLATAAGSSIVLINGARACNVFFQVGDSATLGAGTMFVGNILAQNSASLGSGATVDGGVIGLNGAITLVNDTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6K5</accession>
    <name>A0A9P4P6K5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_424612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6K5"/>
    <dbReference type="OrthoDB" id="4147798at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="124" mass="14368" checksum="5B8111ABECA4F300" modified="2023-09-13" version="1">MSKRHNRKRTRSRPRHRDGNKSNTNHIRTLSTDTTSSFTSTTSSFSQTQNIHYPIATAPANHWHQTYSAWQDRRLHYESAREQALEAQRVRFFGGEAGDDNTLLEPMLKVVTDLFDGMTDFEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6X3</accession>
    <name>A0A9P4P6X3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_526606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6X3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040538390" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="156"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2437823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="684" mass="74511" checksum="0FC3332280DDC2FB" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6Z5</accession>
    <name>A0A9P4P6Z5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_174476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6Z5"/>
    <dbReference type="OrthoDB" id="3768645at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2437853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="553" mass="62362" checksum="2A8AD461C433A79D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7H0</accession>
    <name>A0A9P4P7H0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_437544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7H0"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000433">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="285"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="650"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2437939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="690" mass="72470" checksum="7860AA92BE20AD02" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7Q6</accession>
    <name>A0A9P4P7Q6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_115223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7Q6"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="535" mass="61278" checksum="74248582DEFF6A31" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P911</accession>
    <name>A0A9P4P911_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_490812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P911"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2438764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="151" mass="17495" checksum="468F7A2E1AC211D5" modified="2023-09-13" version="1">MSLGTQGAIPEGAQDNNPDVEAQWAVQAGKHMETYWNILEKVKGSSLRLTKFDDDIYAHFKKDFPEIDVGSKLDQDALKSMEGKERWRTFMEEYKNTVDDYNFGTMLRDSPKVEYGPDTTMMSVRMQFYAIEIARNREGHNDWIYDKAHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9H7</accession>
    <name>A0A9P4P9H7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_114292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9H7"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="97" mass="11437" checksum="793409233875270D" modified="2023-09-13" version="1">MEAQFPVLKAPFANSLNTCTPFSHALLRLQSTLTKYKIGFRYLRFPTGYTPPRYKRPFKVYQIRCRPIRRMPGQYFFQFIGGIVLMTISGWRKLPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9I3</accession>
    <name>A0A9P4P9I3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_112824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9I3"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="64" mass="7226" checksum="4686EEB5F5AEF10F" modified="2023-09-13" version="1">MIGRPVRYYCCQPHLSDPALFSCPTQLGMRCLINAHIDGNVLPIIASLLYVIVIYWGNWRGGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9J9</accession>
    <name>A0A9P4P9J9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_436507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9J9"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13299">
        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF15">
        <property type="entry name" value="DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="255"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="394" mass="44182" checksum="4C9ADA17AEE82125" modified="2023-09-13" version="1">MTETNLQTPTKPISIPPAPMALRASNAGIMSPVDQNGSFAFDRVVKSGTIMKRTRKTKQWKPVYIVLRPNLLSIYRDEDETKLRHQITLSEITAVARQKDSKKKIQHVFGVFSPARNYHLGAATEKEAQEWVDLIRAEARIDEDEEELVVMSPTGKKTFSGFDRSKREVIGSSSSEVERPTSSVAPENMHSAQRTSHTLQYSGNEYGSMSDFSDTGGPVHARFHGSTNSLPPPKEQQLHNTSQQSSIGTLPDDERVIYHGWLYVLKSKGGVRQWKKVWVVLRPKALGLYKNEEEYSANLIIPFSSIIDAVDIDPPSRSKQHCFQVISEEKNLRFSALNENALSKWLGAFKSLLIKRKEAEQQRVLQATGTTQPRRTSTSAQQPAQKNKTPAANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9S2</accession>
    <name>A0A9P4P9S2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_368898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9S2"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF5">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="155"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="155"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="455" mass="50672" checksum="32AFC5896CCD042E" modified="2023-09-13" version="1">MQWGTYNNHLTNPMTRDSFGYSFPMQYSSGSAAAYNYDQTAFNNKHNITYQCGLPASCPRSLNNTFDMTGLPRAGVNVPSFPPPLYQMGPQQPYEGMDLSQSPNNNLLQLDTEYEDYPRPIPENMTSYSTPYDSSRSSTPNEGSPLLHRDDGVFDKDRPYAQLIFDALKQAPNHTMILRDIYDWFRKNTDKALDKDTKGWQNSIRHNLSMNGAFEKVDQPCEEAKKGFMWRLTKDALANGVKSTTRYRSKQPNKRGHRTSHYPQRQRAGAMGGRSAKKQLQHRARMHDAYRSDPYQAPSRSMPTPATFDSTFNSNMSMYSGSPSYYSPSGSDIDAMEYQPEAYGTAPEQRMSQQIFHGLPSAPMSSPLASYSDGYIQLPSDPAVPLFTSSPADTPSPSVSEPRTPDSQSLGWEDSIYGPMGGTGHVGFDLSGFSIAGTSDIPHAHFSHDPLGNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAZ1</accession>
    <name>A0A9P4PAZ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L22e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_435650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAZ1"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2439784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="129" mass="14798" checksum="B81E41E15C9AA3BA" modified="2023-09-13" version="1">MPSTKRATGGAAAKKSQKITKKFIINCSQPVNDKIFDIQAFEKFLHDRIKVEGRTGNLGETIQISQQGDGKIEVIAHQEFSGRYLKYLTKKFLKKQQLRDWLRVVSTSKGVYELRFFNVVNDEADEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB70</accession>
    <name>A0A9P4PB70_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_489690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB70"/>
    <dbReference type="OrthoDB" id="10484100at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="159" mass="16786" checksum="9EB77152F01FD4FF" modified="2023-09-13" version="1">MSSIQLPAQFEVAILDPQPPTAADNTCFGTTSEGGSCEQQLDPGAIERVNNLVASLQNIDPMKLVSEHLTLGPQGGVKDCFCSAHKEQSRSVVLAWLRQIRAVGKARNKAGVERWLEGVDAADGEGPAPEDEVEEGGESEAGEGGLSEGEEREGEREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBF4</accession>
    <name>A0A9P4PBF4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_457825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBF4"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2440118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="578" mass="64981" checksum="5B8DAE98DA4EF1D0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCQ2</accession>
    <name>A0A9P4PCQ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_488534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCQ2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2440953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="161" mass="18155" checksum="AF9A7DB4F3935BBF" modified="2023-09-13" version="1">MSTLSVRQEQVLLEKALGELRAFEHLNMTHDQLRKHGDVQDTVMNGIRELGQKSAYARWYWRKTEGNWVPRYYLDENGREEKVVAKIEVNGNARVNLKIKGNGHTKVSTEADAKEIRKMEICIAKSKQEDDADAADGEHDALTGSPLEIGIEVHLKGGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PD97</accession>
    <name>A0A9P4PD97_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_418741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PD97"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF2">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2441885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="261" mass="27688" checksum="5B1B8B6045BF10A4" modified="2023-09-13" version="1">MPYSLQGRNVLVTGGSAGLGEAISISFAKEGANVAVNYFNRIEPAQNVVQACEKQGVKAVAIKGDMCDTSECRRVVEETIKQLGGIDVVISNAGWTRFSDFADLDSMSEDEWDKASTLSCYSCWAANVKAPLALLKAAKPTFEANPDGGAFISSGSIAAVSQSGSSMPYAVTKAAQVQLIKCLGATQGPKIRVNTVLPGLLLTEWGRKYSDEKIQWAKDTAALKHETDLQDCADAFIMLAKNTSITGARIQVDAGLNVQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDK2</accession>
    <name>A0A9P4PDK2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_418755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDK2"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="489" mass="55697" checksum="9A51E4271EE96631" modified="2023-09-13" version="1">MFEFVSIGPTGRALPVDKLRIRSRAARDKNKRADSRRSRREAKRLALLHKEIVACASLSLPSPPPHDLQLVPFAEKIGGESQQLLYKIFSFKTLEQGKPPLERCIDFTLWDNACFEWLQSDIAFLQSVLTSAAMVDDTNRLSKKQPGNKMWHHLNRTMNILNSRLSNEVTHVQDSTLNVVLTLSILACAMGDHAAVRAHLSGLYRIVQLRGGIAFLLERPMLHFRINHIDLTWAMMSGERPLFLPAFVSWARVFPSNKQVVSRKNTSSASRFMVDERIVAVFQDMQHAVRLLNQGVKDKTRHTGETFQPILNSIQSRLLLLEGRIEDTFSECMRLAMLAFLSHAMNFPSVQFRATYLETGLKYTCKLLGQDGDYKEDGRLALELWIAVIAAGSLSSFRDDWLTQRLVSTVREHIPTWRDAKERLLSVMWIESIHDVPGETIFRRLFQDDEREFQLLPSPDRSSGATPPLPTNESRSVQHVEVQAIDLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDZ2</accession>
    <name>A0A9P4PDZ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_474679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDZ2"/>
    <dbReference type="OrthoDB" id="3594103at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50762" checksum="9A5526653076DBD6" modified="2023-09-13" version="1">MAKIKDKKLGSTVKGDGAIEEVAPSANPEPSTAELEAIAIPKPKAKQTPLSPYARNPITINVGPAPVPVTYYVPWHLLKSTNWSTVPAGGEISLPTMSVDTGHVLVHYLYTGAYQTLTSIIGIALQPQLALKQALLVYKASVIYALDGLEQLARQQIEEHSASMDLNTILDIARSELPKKTEPSGWLQAYLKDKTQKAFEKDHTVFADDSFCASLCKKSKLNDYVMCHVVKLLSEKLTQALAEKGTIAHELDKFPHPQPVPEEVIADKYPFAGLSKTQSKELEEKMREGEEKVRLEEEEAVAAALARYDYIGDDQPPAPDVGEESAPVKEPETCWEASVPAPEPGTYYKLSIPAPEAEPEDSINVVYSGPQEEERSAPEPPKSIWDEYVPPRPKKETNIARKKRLIREKKDKEKWNKEQQERIDREQKEVPCEEPVPTFDTCGAGSNSSWEHACELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDZ8</accession>
    <name>A0A9P4PDZ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_487380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDZ8"/>
    <dbReference type="OrthoDB" id="10604206at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="494" mass="56634" checksum="17CAD31AF0114BFB" modified="2023-09-13" version="1">MALFIQRIIFNYSLFARFCKPRQSTVKELGGMPKNKDFKQLKENDSNTQKGMSDSTKQAIATLEKCLDDLHKDSAISPGAPSFTPPDASNDPTYLQMRNILDRHWRLIKNLEIAVGELQLRYSEPRVVTLPPRTVQALQEEHLQGIRHLEQRFNIQEGFKNRAQTLMKGHEDRFSMYDRRIRDIVLELEKCKTRVVALQEAVDKEVVFASQKAIHSASPQDLQNGCQDLGGSGSVNKVIEYGPVGILLRTLHQRLKTVECELEGSKTREAPGDRSNDSSDSTSAQLSKTLEDQPLETLGLHLLESLGHHLMADINQQLKSLGQQTSENLEQLEQRLLATMRHRILEIIEQSLSAAMEQRLLTTVEQRLVEFLEHIPSNLLETQVLKSIEQRCMEFLKFQLTKTLKLQFEKLDNHLKERAHATRTLVKSRMSNLEGRMLPALHEKGEQVEDLQSTQKSMSQMLETLGERVEVLEGKKDKLEEKKDELEEKKEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEG3</accession>
    <name>A0A9P4PEG3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="8">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_415137</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEG3"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="11">
        <location>
            <begin position="13"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="10">
        <location>
            <begin position="187"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="12">
        <location>
            <begin position="466"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="255"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2443545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="635" mass="72459" checksum="8299E8675E5AE6BA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PF04</accession>
    <name>A0A9P4PF04_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_61990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PF04"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="157" mass="16223" checksum="8F55669DC3E64867" modified="2023-09-13" version="1">MASAAEGGGGHADGPEDTLLLHSLPAAASASTRERLNHVQADLQFPEATTQMGCDPCRRVQTAAPRRPLLHCGEAGRLQTHSVQTVFSPMHKLPQGVAVSIAPAGLGPRGASVSSTAVDAAFIIVFVANPHVPERPPCLASRPLLTPRLGMSLSSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFB1</accession>
    <name>A0A9P4PFB1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_365452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFB1"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF35">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="340" mass="36868" checksum="A2A5F57E2CFC515B" modified="2023-09-13" version="1">MASITLKPNVSTLGVISKARQRDRPAGPLPSLKGQTVVLTGGSSGFGLATAHILPTLGVTRLILGVRSTERGEAAAKPMRIANPTCKIEVWELDMLSYESVQAFAHRCAELPRLDLVILNAGVTKLVFARSPSTGHEETIQVNYLSTALLAILLVPILKTKSPANSPGRLTIVGSSQGYSSKFKERSANSLLEEFDKEWSGIPAGSERYSTSKTLVQMLVYKLSQLIPASDVTINNFCPGFSAHTSLGREVPKGAARILMGMMQAALGRTAEQGAWTYIDAAAIKGEESHGSFVFGWEMFPFHPLMYTKEGEEVMERLWSETVADQEAFGIRQALEAIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFI3</accession>
    <name>A0A9P4PFI3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_361137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFI3"/>
    <dbReference type="OrthoDB" id="4760831at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="443" mass="50299" checksum="852D9149BD6A9C7C" modified="2023-09-13" version="1">MPPGLEQALSSSLHNRSGAGTAIAPSATSDPGVGTAAVESIGEVTDVPAGAALESDQRRAAEMQGWWHESIAKNLRPDGYVNVAVLLIRWADELDDLRTSPEAKLESVFRERYNFHTEMVQLNVDTKPQLQMTRHLSTFVEQYDSPDSLLIIYYSGHGVFYEDLGYLEFTSSLNWHKQKGFPQEARVNWTKAEEALHSDDIESDILVILDTTYASNSMKSKQTVSNREHKQFELLSACGMDQTTASPGDYSFTRALIDALVELVMESGDRSFSIFQLNQRIVLDKRRYDTPSQLWSFSRNTERQIRLARLKRNEKDARPNNSSLCRWAQGHLTLRLALRDRWLHREQIELMARSLTKTFSDRPVFGVRSIEWVGYSTTETFSVGTIALTVLAILHWKKLVLRTRQKRDMRVQDKEHAQLQGKRRRGDSTGGDGVSKKLHSDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFN8</accession>
    <name>A0A9P4PFN8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_345637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2443117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PFN8"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="52"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="217" mass="24508" checksum="05EC728BD0AFC321" modified="2023-09-13" version="1" fragment="single">AVLIAISVVLQFYLGDLYALLHVQNMLAAPGPDFINQMTRGLKGDAIAIVLSIIGLWVIKLNFLLFFYRIGYQIKSYLITWWVALVVVMACGVVNLGMVPYDCMLGSTMHITVVCAVESRVQKIYNLYIVSVAIDVLSDLIIMAFPILIVWKTGLNWRQKIVLSSVFLLVSFTISVTVVRGSVFGGVYKSVTQTNRQVIDSSWMLFWWYIEFVVCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PG41</accession>
    <name>A0A9P4PG41_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_392477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2442518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PG41"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2442518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="565" mass="64394" checksum="D5A4DCBAAA0D0452" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGG8</accession>
    <name>A0A9P4PGG8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_445447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGG8"/>
    <dbReference type="OrthoDB" id="10629044at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="289" mass="31108" checksum="399B33DCAADAA73E" modified="2023-09-13" version="1">MDACACCRLCIHHNLGLAAPRRAYLTTLPSTTGNSPKLSEMKRTFTNFVEGLDAKERKKLLQGRVEDARLWNDSDGPSIWGERTSTDAGPQNTNNVRSAGQEEEVDNALLERLGQAIALMNEGLNTNIAVQEGTACPGVESPDDAAVSTGSSPCMPADAGAVDLVGFAGGDTPTTDLDEQVRGDGLNDTPVHGASEEREGEGKGEGEGEGDDDDEIDWEGVPLSVAICCRWPNTERTEEMRREARREMEQAAMMPLPDGDEEDDDDDDGEAGGRVNGVKWVFKRVEQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGQ5</accession>
    <name>A0A9P4PGQ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_474072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGQ5"/>
    <dbReference type="OrthoDB" id="3943860at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="219" mass="24302" checksum="E30D0D8A96A05108" modified="2023-09-13" version="1">MAAQARFFAPPRTPSPKIRIHRSQSFDSPSSRISVTPIDDSPYSKSTSAISKSLPRYDALGAVEHAITARNPMVLHTKMSDESMLSSASSSVSSSPTSDNETFGLFSESPAAPSPVPVTTRVHTQRRARPSNVNTKPDVMPAPPEIFSSSLALSIYQDPTVPMHDPWLVRVVLDMYDIRRFDWMMIAEPIERIWGFKTSSAEVLGILSNNGRVGRRWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PGT7</accession>
    <name>A0A9P4PGT7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PGT7"/>
    <dbReference type="OrthoDB" id="3641893at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="101" mass="11252" checksum="9BE8268F1A14BFB8" modified="2023-09-13" version="1">MAPINFLETVHSLAKRGDDNIAGIPKGLLVVLIMLAGGALVVVIYGLARFMFPEKENMKPVGPEQADYMREVRVRSLNNLMADYAPRGPYRQRQSNHSVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PH95</accession>
    <name>A0A9P4PH95_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_494318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-0862">Zinc</keyword>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporales</taxon>
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            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
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            <end position="61"/>
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    </feature>
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            <begin position="1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PII1</accession>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
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                <person name="Bloem J."/>
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                <person name="Barry K."/>
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                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
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                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
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                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="315"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444796.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="77415" checksum="33C6EAED8E05E34F" modified="2023-09-13" version="1"> </sequence>
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<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIU7</accession>
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        <submittedName>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIU7"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="79"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2444797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="469" mass="50839" checksum="FE1D41FBE9CFFCD1" modified="2023-09-13" version="1">MDRAADGTSTLYDDKFQTQSASATISIHRSQQQEPPQDAIRMKEQQVTEEREQPGAPLEPSKSRPSINNAAAIPNGGLTAWLQVVGAFFLFFNSWGIINTFGSYQAYYETNLLTSSNPSAISWIGSIQAFLLLVVGMICGPLYDRGYFRGLLLGGSFLLVFGQMMLSLCTSYYQVLLAQAICIGFGCGCLFVPSVAILSTYFTTKVATAMGLAASGSSLGGVIYPIVFHKLLPQIGFAWTTRVIGFIILATMLLPNLVMRVRVLPAKSRSLFDVPAFKMPPYALMVLGFFVGFMGLYMPFFYAQVYALTDHITDANLGFYLLAIMNSTSVFGRIIPNYLADKLGPFNVVIPCTLMSGVLCFCFIAVKSAPGIIALMAFYGFFSGTFVSLPPTIIVHLSLNERGKIGTRMGQSFGVVAVGLLIGTPIGGAILDRSGFWAVWVYGGVMLLASVVFLCAARVCYKGWGFVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK65</accession>
    <name>A0A9P4PK65_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_484134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK65"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040232601" evidence="3">
        <location>
            <begin position="20"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2445452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="509" mass="58256" checksum="61FD4075B6AAD06D" modified="2023-09-13" version="1">MDPLHNLLLLFYFLLACRAAVVLRRLYFHPLSAYPGTKLGIVSPTLYKLYRNFKRRGQFIFEIEQLHKKHGPIVRSGINDLHINDPSIYLQITKIGSRFRKDPKFYDRISFRNTSLGFLDPYLHRARHSILVNAAFSPTPKNLQHLAHLVEQKVAKLCDRFDTWAAEGTPVNIHRGMKALSMDIISELSMGRSFGCLDHSNFSNVFLEQLHSIFQEMTWMQKVLFTVAKVSLSTPPWMFKFVHPPTMVMMKELAKPLIRDYVNNKENKENKASNEEPNQKAVIIDALTDPSASKNSEALDFETLSEEIVTLLTAGGDTVSSALIYGVYHICRNEQVHRKLVEELLAAFPTPDDVTYQGAHSLPYLTACIKEILRTSNPLPGRLPRVVPPEGFDLYGRHIPGGCVFNTSAYLLNRHPSIWDRPDDFDPGRWLEANSGLLEQYMTSFYRGTRQCLGKDLAWCELYVMLARLFRQFHVAVHDTSDADMEWVDAVLIVFKGKNLKTILSRRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKH7</accession>
    <name>A0A9P4PKH7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_482836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKH7"/>
    <dbReference type="OrthoDB" id="5408734at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="170" mass="19322" checksum="1944FF0725AFB458" modified="2023-09-13" version="1">MSSTQTFQQTAVEDPDAGWKPSNRPQSTIARNFMSELDDLFRLDDGIDLLEKTVHQKKQAVTTHTQELEALEAKLRETEERLNQARNSPPRRKDSQRRTPVEDTFSVQDKARLESSGSPRPMRQNKENTAPWTAQNMPGALSELTHSDSSTEYVFVDRPHTARTDNGQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PL37</accession>
    <name>A0A9P4PL37_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_431893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PL37"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF19">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="60229" checksum="1FB81C89C1FE02E4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLG6</accession>
    <name>A0A9P4PLG6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_386018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLG6"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="457"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2445468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="779" mass="83715" checksum="5C06BF248ECBC36C" modified="2023-09-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLU0</accession>
    <name>A0A9P4PLU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_431977</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLU0"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2445259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="411" mass="46062" checksum="3ED1DBDB1EE2F2E2" modified="2023-09-13" version="1">MLSRHIDETSWIEWIKGLLAVPFVLHSQPTAVFEPKGESVDATATRTQRRYAEIMRDVEDIVNDHINHQQVGTQNRSKLKLLVPSVANFFTPLALHDAFIWQDHRRFISMRRFVPPSFNDVRIILNTAQVMSIVRNGPLDLITFDGDVTLYDDGQCLTPDNPVIPRILTLMRNGSKIGIVTAAGYTEAHKYYERLYGLLDAIYASDLPQAAKQGLIVMGGESNYCFRFDGGVPDMLALVPKQEWLLKEMVLWEEADITALLDIAEASLRDTVKNMRMEATVVRKERAVGIIPRPGHKFCRETLEETVLIAQKILEMSEVGTRLPFCAFNGGNDVFVDIGDKSWGVLACQQFFGGIEGNKTLHVGDQFLSAGANDFKARLACTTAWIANPAETVGLLDEIAELEEVQARKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLY8</accession>
    <name>A0A9P4PLY8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_359153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLY8"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF35">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="338" mass="37612" checksum="A5DB47B1B0EFD09B" modified="2023-09-13" version="1">MSSKLKQQASYEATFAHNFWKQTLSRVPAIPAGIELAGKTVLVTGANVGLGFEAVRNFLRLRPSLVIMGVRSVNKGEAAAAALRREFLDARIEVWELDMESFRSVQAFAARAERELDRVHVAVLNAGLGKLKFERVDEGGCHEVTIQVNYLTTALLSFLLLPKLRPTTSSSEPGRLSIVNSGASLGLSLEDPGDGRFLDSFDRAEKFNGFGQYGLSKLLIMMFVAKLAQTINPKEVIVNCTDPGATKGTEFFRSVNSWIMSIALRSFMGIIGRRTADASRIYLHSSLVLGEESHGSWTDWIIRAWPKTMYTDQGHHMGERLWDETLEELKFARVEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM35</accession>
    <name>A0A9P4PM35_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_386352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM35"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="180"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="667" mass="74994" checksum="F764D23298302D1E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PM38</accession>
    <name>A0A9P4PM38_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pep3/Vps18/deep orange domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_430622</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PM38"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="10">
        <location>
            <begin position="25"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="626"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="11">
        <location>
            <begin position="863"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="818"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2446472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="970" mass="108529" checksum="062F2BA774BDC4C6" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMF4</accession>
    <name>A0A9P4PMF4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_277296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMF4"/>
    <dbReference type="OrthoDB" id="5369591at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040351530" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31385" checksum="41366053029E1020" modified="2023-09-13" version="1">MRSCAASAALALAASAVTASLTRIGNITLFSDTTCSDPIFLNSWNLGRDFCAKLDKIASSPVDVPFQSYILNERPWCDNGSRPDLNLYRDEACAGLIRSFEPGALYKSEDPDADGTCVAPGGEYRAMAFVCDGFEGAWGGSRCCYSGREYRGRNYRYVERGGPRLHCGEHSVWLCWGRDGFCLTHTERIVGVPGVTNGFYHVSCNQRDGYNPKRNDLCAEFSLHWCRIGSGNLCPSRRVRNDPSRRFAGVTNSVTWSGAVATLASFGTQFIAHKNGVFVFALRVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMG0</accession>
    <name>A0A9P4PMG0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_472109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMG0"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="711" mass="80903" checksum="2683226B28E09F94" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PMH1</accession>
    <name>A0A9P4PMH1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_483995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PMH1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20615">
        <property type="entry name" value="CYP_GliC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF31">
        <property type="entry name" value="CYTOCHROME P450 307A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2446667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="495" mass="56468" checksum="678F534A8C8EA724" modified="2023-09-13" version="1">MNSVRLVVGIAGLSAAVAWCFRIWQPRYLHWSYPIHSSVHAQPIPTCPYQWPNGQGDVAKFLEGEANSDEWRARHGRVYRIWSGTTQEIVLTHPDDVREVFRDSDRHEKAVNNNSGWLMGKLLGRCVGLVSGTTWQQLRAATGAPFTHKSSATYTDDIHRAVEQHFQEMKEKMQLQHGLLNPVDDLRMLPFCIIARILYGDMTLEQGSELLHLTHLRETLFTRMIQGGMTRFSWSRFLPLQTNSDLLQFKRRWAEFNSDIYPQCQAANREVAIVPMYEAVERGSIDTEQLLQTLDEMLFANLDVTLGGLSWNLLFLAAHPDVQSEIRTEARRARQGGNTQVWKSYLASSTTLLAASVLESARLKPLAAFSVPQAAPTARRVGDFVVPPQTNFIVDTRALNMLNSFWGDDAGEYRPARFLGGKASDLRYQYWRFGFGPRQCMGKYVVDILIHAILAHLVLRYRISLDHTSSWDRKQDIWIAHPDTKIRCESLERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNI8</accession>
    <name>A0A9P4PNI8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B3/B4 tRNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_430658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNI8"/>
    <dbReference type="OrthoDB" id="5587917at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39209">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39209:SF2">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B3/B4 tRNA-binding" evidence="1">
        <location>
            <begin position="73"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="238" mass="26300" checksum="C6A2E51E7D046C5E" modified="2023-09-13" version="1">MSTLANPQQYLDNARIAPEVFQLRPDYRALLLVITNIPPAPSDAQSEALLQEAEASAKASLVKTPVTDIPHVRAWREAYTAFGAKPKKTQNSLEALTRRVDKGLPRVNRLTDIYNAISVKHQIPLGGEDLDKYSGAPFLIRAKGDEKFEMNSRGEVVNEPPSAGEVVWCDDVGVTCRVWNWRQGPRTALTDDTTNVLIIMDALQPFSDNQLDAAAEELSQLLSGLSPEVKVLRRLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNS6</accession>
    <name>A0A9P4PNS6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_430747</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNS6"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2446638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="168" mass="18215" checksum="6AC0438737683D22" modified="2023-09-13" version="1">MSSSAEQNLVDGNKAYAASFTQGHLALPPSQKYAVLTCMDARIDPAAAFNIPLGAAHVIRNAGASARDAFRSLVISQQLLGTTEILLVKHTGCGMLTFDDDTAHGLVKKNKGEAAAKEVENIDFLTFPVLEEKVKEDVEWLKSKAVEEGVRVTGWIYEVETGRVRKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNX8</accession>
    <name>A0A9P4PNX8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_255685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNX8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="158" mass="17726" checksum="FB97D8711579A888" modified="2023-09-13" version="1">MSLRRGIRVSNYHARYRGGSRQMTLRNRPRPVCTSPRTLSLVSPSKDLSSHPTSHRYLHPYLYLSHLPTYPHPSSTIKSPPPHTTPHKRYQISDAASAAPPLASDTTTYPRPDQTRPDQTKRLHHPRPSHPIPSHPIPSIHVPHTCTPPSSYIPTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ59</accession>
    <name>A0A9P4PQ59_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_352670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ59"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF2">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE AUSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="664" mass="73639" checksum="DA7FB447DC567299" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ84</accession>
    <name>A0A9P4PQ84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_453352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ84"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF24">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="63"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="517" mass="56444" checksum="497BCF964D9736E3" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQG7</accession>
    <name>A0A9P4PQG7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_430062</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQG7"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MSL3 chromodomain-like" evidence="11">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="10">
        <location>
            <begin position="126"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2447134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="324" mass="37403" checksum="9B2F0E0BEC806D94" modified="2023-09-13" version="1">MAPAPVVEAQFKKDEKALCFHHELMYEAKIIEVSSKEEAEKKNGYQYKVHYKGWKNTWDDWVEEDRLRKLTPENRELANSLRHAVLEQQRAQRAQAAPVKKKTQTSTRGSEERQTPVQAAPPRGQKRMRDQDLEKEEAFTTRRAVRILMPDRLKSILVDDWENVTKQLQLVSLPAKYPASVILDEYFAHATGSSMRTNAEVDILQEVIHGLKEYFNKALGRLLLYRFEREQFFDIYSSITQPTGDLAGKAVADIYGGEHLLRLFVSMPELIAQTNMDVQAINRLRQELGAMTHWLQKEPQVTNFFQSVYESPGSAYIEKVKTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQW6</accession>
    <name>A0A9P4PQW6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_379748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQW6"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="83"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="480" mass="54125" checksum="EBDB984FC8EF567A" modified="2023-09-13" version="1">MSFSADKLPILQRSGTFSNRRFSSTKDPTENELTSKIHRQFRDSHEGHKAHAGLDPTRASTGVVWTSERAYEHGYLDNPEAWANLGQGAPEVDDEIQGCFERPKEVDISSHGREYGPTAGIKPLREAVAKLYNEHHRKWRKSQYTWENVCIVPGGRAGLIRIAAVLGNCYLGFFIPDYTAYNEMLSLFRNIAAIPIPLGEDDNYHMTPDLIATEIARGTSVILTSNPRNPTGQMITNPELAQIQNICRDRATLIMDEFYCGYNYTTNCDGTVISAADNVEDVDEDDVLIIDGLTKRFRLPGWRVAWILGPKEFIQAIGSCGSYLDGGCNVPFQEAAVSMLEPPRVRNEMRALQMHFRTKRDFVVGRLQDIGFKFPFMPNSTFYIWLDLSHLPESIADGLNFFSACLEEKVIVVPGIFFDLNPSKRRDLFDSPCHHFVRLSYGPKMDVLAKGMDSIERIVKKHKANPRPIHNVRPRGSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR29</accession>
    <name>A0A9P4PR29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Distal membrane-arm assembly complex protein 1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_427905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR29"/>
    <dbReference type="OrthoDB" id="6604875at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053092">
        <property type="entry name" value="Mitochondrial_unc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048:SF1">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15055">
        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2449740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="92" mass="9924" checksum="4EA2D6949056C3CD" modified="2023-09-13" version="1">MSLSKDPGVPTFKEALKNDREQFDDCMPCRIIGSGAFIGLGAYTYMSGHSQLKAQEAAIKRSKSIFGMASRRAAITGTATVLVGAGVYRWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PRC3</accession>
    <name>A0A9P4PRC3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin Nup120/160-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_382336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PRC3"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21486">
        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="82"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup120 helical" evidence="5">
        <location>
            <begin position="652"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="6">
        <location>
            <begin position="878"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2447476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1216" mass="137282" checksum="72AF7FA111DCB42B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PSW9</accession>
    <name>A0A9P4PSW9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_349850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PSW9"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14076">
        <property type="entry name" value="STKc_Kin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000397">
        <property type="entry name" value="Serine/threonine-protein kinase KIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034674">
        <property type="entry name" value="STK_Kin4/ppk1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="240"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="546"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="736"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="797"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="847"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="892"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1059"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2450760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1076" mass="116280" checksum="E28CA053E6641F6B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT02</accession>
    <name>A0A9P4PT02_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_470173</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT02"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2448394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="284" mass="31753" checksum="3C1139E695F5CD43" modified="2023-09-13" version="1">MASQNGAPSSPHADISFPINRPAEAGNWTPELDAKIRAQEAANIRLKKAILPRYLWPGGDRSLAGIAIRAFLLGASGAVGFVLTAALAYSGSPLWRPCFFLGVLCVFHFLEFWTTAAYNTPTAYISSFLLTNGSRYRQAHTVAFAETIITSYFLPAWQARVHPPWVVALGVAMIVVGQVVRSLAMVQAGTNFNHQVQQQKNEGHELVTTGLYSVFRHPSYFGFFWWGLGTQVALGNTVSFVGYAGVLWYFFYTRITHEEKHLIEFFGDDYKAYKTRTRVWIPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PV32</accession>
    <name>A0A9P4PV32_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_480541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PV32"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2449459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="124" mass="13874" checksum="DC404B1BECCD3D18" modified="2023-09-13" version="1">MPSSSPSRYQRISLRLTVFLAFVLLLLKFGNVIGAGVFAGDRSSDGIANQTLGFENIFVLNAPWRTDRKDAMSLAAAYNKIQFEWVDEVQEETIQEKAYPPGNHRKLSPGGLGSWRAHMDAMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PW95</accession>
    <name>A0A9P4PW95_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_425888</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PW95"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2451377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="372" mass="40779" checksum="DB015E848498EE4F" modified="2023-09-13" version="1">MVVGSVLVTGGTGYIGSFTALALLEADYKVVIVDNLYNSSEEVINRIELISGKRPEFYKVDVTDEAALDKVFSKHPDIDNVIHFAALKAVGESGEIPLEYYRVNVGGSIALLRSMSKHNVTNIVFSSSATVYGDATRFPNMIPIPEHCPIGPTNTYGRTKSTVEGMITDHVEAERNNAKKAGKTDGGKYNAALLRYFNPSGAHPSGIMGENPLGVPYNLLPLLAQVAIGKRERLLVFGDDYKSKDGTAIRDYIHVLDLARGHEVALKYLRENQPGVKAWNLGSGRGSTVFEMIKAFSHVVGRDLPYEVAPRRQGDVLDLTANPALANEELKWKTELTLEDACADLWKWTENNPEGYGQAPPKEFVEALKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWE5</accession>
    <name>A0A9P4PWE5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_347786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWE5"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2451452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="465" mass="53421" checksum="BA5CB03B04BBB87C" modified="2023-09-13" version="1">MNRFALFADDDEELSPVMATTSKANPFVNQIADNDAPWEEVRRGGQAAKFNLKTLVIRNENKTTLPRCYTKARDFSGSTQDSDSMKLADPHEHWCGVCHIRFPSKNALLTHIKQSPQQHKNYCNLCKRVFVDRNGLKNHVDNAAGHDVTCNLCLSAFKDAWGLKNHFENNYFVAGHDFICLTCLLGFRTQTELDRHLFTGAKHVWCHTCHRKFRNQVERDEHWRLTTKHRHCLQPGCDFDAPDEKALENHLHEDHFQCEGCKRIFPSQTKLNLHCENCQFEVTCDCGFRCAGRAKLELHMETCFYCAECHYHTSHEGNYQIHMTKHAAAAIPCWCCLLPMRKCSALIKHLESGSCVKLPNPTQLMRCLGTFWYSTLYMDVDIHVQIRSNRVDVGETVSWMKDGLLQPFICRGLGCGETFSDFSSLVLHVESQDCEWDIEKLRLDLVQAEFSRMCARKDSFTAMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWJ8</accession>
    <name>A0A9P4PWJ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_439184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWJ8"/>
    <dbReference type="OrthoDB" id="5367448at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="261" mass="29394" checksum="0A12CA9E14FB5DE2" modified="2023-09-13" version="1">MAVRRASTEALSQRFLHLRISPRPANLSESREILRVLQRFGEVSKYYHMQFEYHSPVPNSALLIYRDAAAAHAALAASPIRFALERIHHDPKTAHETDDYNLSLFDQDAPDVAPPPQTTPGIDEIRAPSALLTRTTPNPQPAPADTDTDIDTGAHAPLPFAPPQKQPKTVSRWFQVTIDRSHAIHQDYVERQPLWAQFEPMKSLAQLDLAPKVPHVGLSDVTKRPPHAYRTPNHVLALMNKHLQYGQESLVRMWEEGEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWL0</accession>
    <name>A0A9P4PWL0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_12118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWL0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2451801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="123" mass="14012" checksum="2325019080F590F5" modified="2023-09-13" version="1">MAMSCATAYPEQIAWPSIAGGKRCVSAAQPFDRTLKRIRLRMQRTQRIGSVGLCVLPQMSYSAWHYASIQAHCLSLRATSRRSRVRAELEPLWRSKQAKQLLDVRRIPSCEPQSGHLRCYRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWX1</accession>
    <name>A0A9P4PWX1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_349785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:15592"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:142742"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60561"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWX1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF30">
        <property type="entry name" value="PROTEIN-METHIONINE METHYLTRANSFERASE LAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="289" mass="33772" checksum="EE672A26D0178493" modified="2023-09-13" version="1" fragment="single">ENGRLYHGFRRGLYMYPCDEPEKDRMDIYHKLFLVARREHLHQAPIPQHWAPRILDLGCGTGIWAIDMADKYLNAEVYGLDLVNIQPEKIPPNLRFRVPRDYESPWALGEESFDLVHLRMACGSITSWPEMYQKIFTHLKPGSGWIEHVEIDLEPRCDDGTLSPDSHLKQWYTYLADATARVDRPIAYDHRTRQLLQAAGFIDIQETIVRAPYNSWPADPHQRDIGRWYNLGLTEGLEALSAAPFTRVNRWNMNEHVKPLVEAVRREVCNRKIHAYNNIHIWTARRPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWY3</accession>
    <name>A0A9P4PWY3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_376153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWY3"/>
    <dbReference type="OrthoDB" id="2128064at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="3">
        <location>
            <begin position="81"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2451742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="220" mass="23901" checksum="B8440EB199E3378F" modified="2023-09-13" version="1">MTLLSNRVTVPLRRFRPLLTNCALPRTPLCSSAAWASRQDASTSQRRLKCNKSGSSTSSCPGEATRPASFTAPQFWTSKATWKRAGINTLRCLIGCTLGDFSAMWYLQLSHPALGMGTIMAISMASGITSSMLLETALLRYGYDRLPWMAAARTAAGMSMISMITMELAENVVDYHLTGGAVQLDSAAFWVAALLSVSAGFIAPLPYNYVRLRKYGKACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX06</accession>
    <name>A0A9P4PX06_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_493363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PX06"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040460820" evidence="1">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2451815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="139" mass="15556" checksum="AE3E4EEE92AB5B82" modified="2023-09-13" version="1">MLLSRPVLALAGLLSSTALAAPQYLETVYLVNCGNSFSEMDYYAEGHSSFDGSWPNDQCRMSGSGTTWWEGVARSCNFGSTTFTSHIDSDASSKPAHSIVGWGKNKYHEYSCRKEDNYRLLYTKNGAECRSIYYCTWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PXS9</accession>
    <name>A0A9P4PXS9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS monosaccharide transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_450826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PXS9"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2452207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="520" mass="56626" checksum="AB21164936D9BC4F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4Q015</accession>
    <name>A0A9P4Q015_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_16596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4Q015"/>
    <dbReference type="OrthoDB" id="5428925at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2452024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="688" mass="76439" checksum="D4CA33ECE737D8BA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4Q0A1</accession>
    <name>A0A9P4Q0A1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_20369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2452159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4Q0A1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2452159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="89" mass="10324" checksum="CD1112F903E9B0EE" modified="2023-09-13" version="1">MTCFLVSSLFVGAFRVGSVACLCYLRFFSIPLPFVALLAVQHTCMPLLVRFLFELLHFHTMRTVLMGMWMAFIQFVRQDWKGTHVRFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U4B3</accession>
    <name>A0A9P4U4B3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_437390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U4B3"/>
    <dbReference type="OrthoDB" id="4426556at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF52">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2437764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="500" mass="55262" checksum="B6818A836BC3CF2A" modified="2023-09-13" version="1">MRNPAMEPAPTTDSKAGSITWDGPDDPTNPFNFSQAKKWRVTLLACFMTFVIQINGTAMTSAAEQINESFHISDESFPHSYWPVFSWTLSGAAAPMLGLPLMEHFGVRWSYMMLYATLIVFTIPQAVAQNYATLIVTRIFTGGCSATLANITSGILSDIWRDGRAKSFGTSLYIWGLLAGLNTGPIIGSAIVHYTTWRWIFYSQIAFYSAMFPIVFFSLPEVRPDVILTRRARHLRKTQNLNIYAETETQRTSLGEILRETIIRPTRMLCTEAVVFSFGMWSAFCIGTAYMFTQSIVQVYADLYNWDYYLTGLVQSALVIGEIIGLVASLGQDELYFRSARTNKEQPGAPIPESRLYLSIPASFIGLAGGLFYFAWKSYPSIPWIVPTIALALALVGFGMFCSVTAVTTYILDAYAKYAASAIAGAAFLENVLAAFLPLATQSMYRTLGFHWASSLLGFLALALSFVPVVLFVFGGKIREKSPFMGESVYVHEEVGGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5M4</accession>
    <name>A0A9P4U5M4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_437241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5M4"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="144"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="444" mass="49642" checksum="79683BD0D4D3104A" modified="2023-09-13" version="1">MKGAAGVGLLGSTFALADTLQQVPQKPILAEACPSDSILYNGECQPAIMGARSTTDNIRQNTTITLEEARASAQEYEEFPWTFLPECYSNEKQTEPVCVFSDQNFADGRGIFLVTTTPLAHQMLKKPAFSQPGALSRINQHSNPPFEEHEFPGKGRGIVANKTLHRGDQIFASTPLVISNPVSYNLTDPERLRLGHRGVDTLPSATQALFWKLLDHFKGDPVEDRINTNAFDITIDDVQQYAVMPEIAMMNHDCRPNAAYFWDEDTLSHYVHATQTIYPGEEITITYINNERKREARMKNLKTNWGFDCSCSSCAAHPIFAAESDARIQAIEDIAEALNDWTPSSTATPEMAETLLSLYTQERLEASMGVAYKHASEVYSSFGDRYTAIKYAQLALELLHLDRGFSDTDIKFMLAMAKDPEQSWSWKKRVGHKRFESASCGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5U7</accession>
    <name>A0A9P4U5U7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_501531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5U7"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040266966" evidence="2">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="174" mass="17566" checksum="E8A87D373E86493D" modified="2023-09-13" version="1">MKLLAITLFAAAAVAVAIPAPNEDVQGFQCRRNSAGRCTRNTNTVASDPLASDPLASDPLASDPLASDPLASDPLASDPFASDPLASDHLASDPLASDPLASDPLASDPLASDPLASDPLASVPLAARSDTLAARSGPLASDPLASDPLASHGTQGFTCRRDSAGRCTRDAQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U718</accession>
    <name>A0A9P4U718_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_437039</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U718"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2438592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="91" mass="10443" checksum="3E8284DA3B4C503B" modified="2023-09-13" version="1">MDSLSSAEQRELQNRMEKKQMKEFMNMYSNLVQQCFDNCVNGFESKSLTSREEGCIMKCVDKRMKGSQRLGDRFQEQNAAMAQGQQSGFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U825</accession>
    <name>A0A9P4U825_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_488293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U825"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="111" mass="12380" checksum="798E8B6C52ABE85E" modified="2023-09-13" version="1">MASSTAPLQEWLVIAPDFEGALEKRLAVRPEHISGLKADAEDFWLWGGAMLEEPIAEGQTPKMKGSAMLIGASTREEVVERLKKDVYVQGEVWDWSKVQIIPFKSALRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8B8</accession>
    <name>A0A9P4U8B8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_489669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8B8"/>
    <dbReference type="OrthoDB" id="3796224at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2439882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="274" mass="31364" checksum="B8719C28BDDA780E" modified="2023-09-13" version="1">MNQGTGILFPKEGASGEQPEFECFPHLVKPGYSFRKREYSPGYVVPVSDDDDELLQFNDQESKFVQQRPMETEVIDHASLAPWPLSWHTMPKKSAEGMSAFTEGQRIYCVKVDEEIRVSNVIVYPTDKQHLRGITWAVTLNHYIATACRKAEWDVRWAELNDRPNALAELRQYYGISNGFLPGPAHVFGGYWVEDEMESSELLLRWVITSKVWIFLHPGIQVYVKNFASWGTLKDHNYPPGNNRVDPKEATARVKYTIGGINLLHDDEEDEAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8N7</accession>
    <name>A0A9P4U8N7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_100241</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8N7"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF21">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2440378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="549" mass="60018" checksum="FD03A6D1D87FE694" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U994</accession>
    <name>A0A9P4U994_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trichothecene 3-O-acetyltransferas-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_78738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U994"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58184" checksum="F0913AE03093A6BE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9H8</accession>
    <name>A0A9P4U9H8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_394161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9H8"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF222">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="561" mass="63407" checksum="3339FA1B5A4E3C88" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9Z3</accession>
    <name>A0A9P4U9Z3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate esterase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_475191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9Z3"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040238902" evidence="4">
        <location>
            <begin position="18"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="680" mass="74058" checksum="3E09F7A8D4C59E32" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UA69</accession>
    <name>A0A9P4UA69_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gpi1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_27625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UA69"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="709" mass="80981" checksum="A077D7CBC453C4A2" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAC6</accession>
    <name>A0A9P4UAC6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-galactosidase</fullName>
            <ecNumber evidence="10">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_51807</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="10"/>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAC6"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040230880" description="Alpha-galactosidase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="12">
        <location>
            <begin position="355"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2442911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="441" mass="48934" checksum="0D11E310F41523DA" modified="2023-09-13" version="1">MLLKLLTDLTLITSGAALVLQDNVGKLPALGWNSWNAYHCDITEDQFLSAANEFVHLGLKDAGYQYVNIDDCWSDKDKRDESTNRLLPNLTRFPDGIKGTAHKVHELGLKIGIYSSAGTQTCAGYPASIGFESIDAATWSEWGIDYLKYDNCNVPSNWSDSCNDCVPDSMHRDDLVNGTCTNTNGLCPPGYDFSTSNTAERFRIMRDALLAQNRTILYSLCEWGEAGVQTWGNATGSSWRTSGDIDPTWQSVLAYLNQNSFYLNYVDFWGRIDPDMLEVGNGLTIQEARTHFALWAAMKSPLLIGTDLAKLDQNNIDVLKNKYLLAFNQDEVYGKPATPYKWGTNPDWTFNATFPAEYWSGSSSNGTLVLLFNPFDDTRTKTANFEEVPNLVGGARYSAIDIWTGGDLGCVDSLQAEVEGHDTAGWLVGTKCERETHVSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBC9</accession>
    <name>A0A9P4UBC9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_432192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBC9"/>
    <dbReference type="OrthoDB" id="3789144at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040221164" description="DUF202 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2444110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16897" checksum="AFA41D698EBD99CA" modified="2023-09-13" version="1" fragment="single">MRSVTLLLFFLSGTLSKAQVPFLPDPQRKYVLDVIARALEEEDPVVRQALVATIGFPYIPYQTKGLSGNGRVIIFIGIMMLLINLFCLYVICLWSSYIFQKRGIRNRYQRRSTARNLRLEQEDFLFKQQEFLLRQEAERKFNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBF1</accession>
    <name>A0A9P4UBF1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_27044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBF1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="91" mass="10992" checksum="CB6A18AC076813A3" modified="2023-09-13" version="1">MRKQLVKLQHCMKASLDPWWFDIVARCMRWEIMTHKAWNGTSIRRIWMDAETSWSKSYYLSTTLLGWLRLLYLFASICVLTTYFHNTSLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBZ6</accession>
    <name>A0A9P4UBZ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_356736</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBZ6"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="265"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2446164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="679" mass="73603" checksum="1C565052DC906517" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCC3</accession>
    <name>A0A9P4UCC3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor Rba50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_473357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCC3"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="319"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2444203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="59486" checksum="BD91A0B84DCA77AD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCK9</accession>
    <name>A0A9P4UCK9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nep1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_463948</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCK9"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2444277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="277" mass="30749" checksum="3D1A366471EA218C" modified="2023-09-13" version="1">MGGLPLRNDSPSDRERKPVRDSPERGTKRIRTQSLPPPDLPKLVAEQHQPIPSSDKDTQRMIVVLCSATLETYKASHGVGRGGAGREDKFNLLNSDDHIGVMRKMGRDISEARPDITHQCLLTLLDSPINKAGKLQIYIQTARGVLIEVNPTVRIPRTFKRFAGLMVQLLHRHQIRSTTSNEKLIQVIKNPITDHLPPNCRKVTLSFDSEVVRVRDYIQGLHTNESIAVFIGAMAKGSDDFADSIKDDSIAISQFNLSASVACSKFCHAAEDVWGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDR3</accession>
    <name>A0A9P4UDR3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_508225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDR3"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="176" mass="18544" checksum="9EFCA659196079E7" modified="2023-09-13" version="1">MSTKLIPTKIQGQVAANQTDSTEVQKAAGNSNSAGATENTNKQDSKGKGKAAATSAEYTQGTTSAGDDGDDDDSDERGFICPQCGKRYAQGHNMKRHIRDSHGTGEKAYACPSCSHRSVRNDNLKKHMKAAHGRDWGQALYEAALEVSSDESSEEEGDGSSTGGGEGEEGDAEDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE30</accession>
    <name>A0A9P4UE30_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_238242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE30"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF27">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040451214" evidence="2">
        <location>
            <begin position="23"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="305"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="812" mass="88499" checksum="F52CAA6DA26188AD" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEJ3</accession>
    <name>A0A9P4UEJ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_512030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEJ3"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="16"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2446272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="420" mass="45301" checksum="C337A49AF45F9F5E" modified="2023-09-13" version="1">MASHEFEKVIEKACTDLDIAGCALLATNRDGSFTYAKSFGKAAIGEDKPFQLDTVTWIGLTQISAPASCTKLLVSLAALHLASSNNLSLDDPDLIPTHLPELASKPILLPPREDAPLPETPRTKPLTLRHLLTHTSGLVYDPLSPLLTSWAKTNTKHPFRGGTVSSRFDSPLAFEPGESWMYGPGIDYAGLLVERVSGGTLEDYLKTHIWEPLGIKDMTFHLSRRPDMQARFAAMSYRSAGGRVAAAPENPELAKVAYLTEEGSEPEGCFGGDGLFATGEEYIKVLRGVLDASLIPSSFADEFFAPQLTQTQADALNGLMQISSANNVMGHTNKAVRKNWGLAGLLLDADDHEGGRKAGTMVWAGFPMLTWFVDRKTDMCGLFVTQLLPAGDQKTADLSNAFVDGVYALVASGSEDNGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEV4</accession>
    <name>A0A9P4UEV4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phospholipid methyltransferase</fullName>
            <shortName evidence="14">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">P171DRAFT_383053</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="14"/>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEV4"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="14">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF2447861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="203" mass="22424" checksum="38FC578659A41DC2" modified="2023-09-13" version="1">MSDYIDFSQPSLWISAATILFNPTFWNIAAQSGQEYYNKTITKLFGNNPRYGCYGLAVTIFSLGILRDFLYDTALAHQPTHPALLTPLVHLAAIPLFATGTTLVLSSMYALGVTGTYLGDYFGILMDAPVTSFPFNVSDAPMYHGSTLSFLATAIWKGKPAGIFLTFVVAVCYSVARRWEDPFTGMIYTKRDEERKKAGNKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UF07</accession>
    <name>A0A9P4UF07_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_462154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UF07"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF8">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="5"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2446752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="385" mass="43197" checksum="014A4FAC15C5CB97" modified="2023-09-13" version="1">MGNHALVYGASGISGWAIVNSILNGYPSKDAFTKVSALVNRPLTREMALWPDDPRLQIVSGIDLLKGSQEELEKTLKEKVPDVDSVTQVYFYSYKQIDDNDAECKTNEAMLERAVTAIEKLSPALSYVVLPSGTKIYGCQMLDKFPFANDLPLRETLPPIPEPALSELFYYNQIDCLKRISKDKPWNWCEVRPDNIIGFVPNNNAYCLAQTLALYLSLYRAVQGAGAKVPFPGTEKSWVNRYNESPQDMVAHFSIHASLHPETTASRSFNVGGQEDNWKGKWPVICEYFGLEGTGPEENAPQPGAYIAAHRGEWDALEEKEGLKKGSVDSDITHPGFQYYIMTMFDFDRQMSMEASHGVGYTEVIETPETWKVAFDRMRLAKVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFJ5</accession>
    <name>A0A9P4UFJ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_428276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFJ5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="404" mass="44806" checksum="0EF785E35AB729E4" modified="2023-09-13" version="1">MEHQSRRHAGPEVDARPRPPHDAPTPGASGHDAGSSQDTPASSVGAPKAETHADQGPVDSGVDAGSASEYDQDNSGDHLLEAHNEDNFSDEGYDGSDASSFLSSIISEVRRGVEIEGRRYASYGKHEYGMPMDEKELDRQDLQHHKYTLLLNDRLHVTPIAEERLQRAGSRVLDLGTGTGIWAIELADKYPNCEVIGVDIAPTQPTFVPPNCIFEIDDVEDDWPYRAAHFDFIHGRDLMTAVRDWPRLITQAHTHLKPGGWLQLASTIPGALCDDNTIPPNSGYVETGRLYYQLAEKMGAPLDAPRQWNAQMSAAGFTNVHDVVYKLPMGGWPRSKRLRTVGRLEQMMISDGGFEAYMLRGYTQIMEGKVEDLQIILALARSEIKDPSMHSYVQFHVTYGMKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFR1</accession>
    <name>A0A9P4UFR1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_428410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFR1"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000143">
        <property type="entry name" value="Dolichyl-phosphate beta-glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="13">
        <location>
            <begin position="97"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF2448310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="370" mass="41445" checksum="C0B5B689C18DAC7F" modified="2023-09-13" version="1">MPPTWMLVVALVGLGGALLFWCYMALVLFAPVPREPRRSEKQYITVLPNGDRSDPKELPCWIDKWTAEKEVSKKRTGGKRRETLAKIALEQPELFMSVVVPAYNEEERLTGMLEEAVDYLQQEYAGKGWEIILVSDGSTDKTVDKALQFAREHQLSNHRKSVSGPWKDHLKHEQRIPEGSIRIVELEANRGKGGAVTHGLRHVRGQYVVFADADGASRFSDLGKLVEGCKKVEDNRGRGVAIGSRAHLVGSEAVVKRSKLRNFLMHSFHLLLRLMTPPATAAIADTQCGFKLFSRPALPYIVPYMHSEGWIFDVEMLMLAESGKIPMVEVAIGWKEVLGSKLNVIWDSLGMAWGLAVLRAAWLTGVYKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFU5</accession>
    <name>A0A9P4UFU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_426792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFU5"/>
    <dbReference type="OrthoDB" id="2588159at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="95" mass="10934" checksum="0D9A11943B6ED0F2" modified="2023-09-13" version="1">MEMLAALDWTRGLLDRFQNSNDYDLPLCPPLPFSPSNSWNALLPVYNETLAFGISTNGGDSRYQLEHRKALTDGYQEYLKCFRQWSYSNGSEFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UFW2</accession>
    <name>A0A9P4UFW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_481993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UFW2"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="224" mass="25277" checksum="C6E731062E389DDC" modified="2023-09-13" version="1">MPNVLVLSFEDFSFSSRQLYEQLLPKLLSRAAIHESLTTQDAINYILSGWPNVILVTDPVIAEESEESQKLLETVADYTKHHSCTTILMGFFVAAIETQTLDYIFKHHFHLRWKAAPEEHTSHEARLIASDQSLLRTTTLVPKFVAQAAWLTQVTPAQATYLGPIERGWAYAAFTRVGLGKLGYIGDTGFGDEPERLVLAMCHLDRPEDRVREEEGFDNLRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGF7</accession>
    <name>A0A9P4UGF7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_427724</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGF7"/>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2449526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="452" mass="51897" checksum="E7520DDBF9C79C99" modified="2023-09-13" version="1">MSRLRPLARIPWCRRPLLQANRRYVTSQSPQAAVEAYNQSLPPGWEDEAPALSDFSELPHKDFGKNQLIETNEEFKRSLRGILKQFPPITYAFAYGSGVFPQSDATASRITHSPHPNPPEAILKWQKGGGKMIDFVFTTRFSQHFHSLNLREHRDHYSFLGKLGSGVVSHVQDRYGAGVYFNPYITVNGTMIKYAVVNFETLHRDLTNWDTLYLAGRLHKPVKILFEEPNIRVANQRNLLSAVRCSLLLLPQSFTEKELYSTITGLSYQGDPRMTYGSENPKKIDNIVTHQIRNFRLLYHDLIMSLPNISYVDETAISKPDWMDDTALDLKLNQDMDVERRANMVRRLPKSFREKVYFLYQRKFAIPGREFQEMLEASKDEDAKGGLKKQVGGAFDRRIAAEKDLPVMVTKAINQTVHWPSTVQSAKGILSAGPFRAWQYLQEKREKGKMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGP3</accession>
    <name>A0A9P4UGP3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_470211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGP3"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="408"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="323"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2448447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="625" mass="69592" checksum="5824EEA9A2558487" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH77</accession>
    <name>A0A9P4UH77_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">P171DRAFT_469388</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH77"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040513821" description="laccase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="97"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="224"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="449"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF2449303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="616" mass="67698" checksum="DE65B7A5576A7631" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHL9</accession>
    <name>A0A9P4UHL9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_427877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHL9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040282351" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11473" checksum="BA602E8E28D1B6FE" modified="2023-09-13" version="1">MSSILMLCPFLCCLPPVPVSDRSCTVPTVCVATPDLVREIQAPMVCAPHQMSTRLPRRRISLSKNITSKTRRRRYRDGALCSRHHQAPFDVSCVGTHGASNGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P3F6</accession>
    <name>A0A9P4P3F6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_491946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P3F6"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="175" mass="19458" checksum="84F4CE3349ACA7CE" modified="2023-09-13" version="1">MSSKAVLKAWWMRVSSSWASRCFCRTSFTTTFEGFSSGRSGSCNLKKEQAERLLVIQQGTQAILSSSLLLLFTNWKQARALLQIFVEDAEKVSVVSRGFLILASIPKRVASVLSARGRPSSLVTKEPIEQTDRTVTIMRRNVAYKAEVVVIELSEQSEKVASTLQVKTHVQESAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P407</accession>
    <name>A0A9P4P407_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_319636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P407"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2437920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="243" mass="27685" checksum="C644C0CCD39D2930" modified="2023-09-13" version="1" fragment="single">RFWCRYVHTRYVGLDDWSMLCALVVAIGVGIQNVVHISWGTGRHGSDLDLLVILEPTLKHWYAYQMVYPWSLFFVKASILALYHRIFTKTKFRRLVYAVGAFVATYTIIVFFAFECPKSPPQAWSPKFPTGCNNLPATYFSTASVNILTDIVILLMPLRAFWQLQLHPRKRWALIGVFLVGGIAVLASIVRLYALYVYTYTQDVAYDAIFILLLSQIEVNVAIISASAPALRPFFKKAFKNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4D1</accession>
    <name>A0A9P4P4D1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_398989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1015"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2438130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118804" checksum="AFC53C6D70C6276F" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P4L1</accession>
    <name>A0A9P4P4L1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_492309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P4L1"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2437207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="185" mass="20769" checksum="14A6CD193E7EF343" modified="2023-09-13" version="1">MSSTTPGSPHVLTGASTVWVVTNLFVEGFRCPLGDEWPLYSQQCSAFFARWVYIGVFDMAIELALFATAFHFIWNRHIRLSSRLAILAAFACRLPNIALTVLRLDMTLTPENSGYWKSRVACTTQMAIGWTIFSCVTPYLRPLITAFPEQGEDAASSCNRADERLKVRSGQLPGMRAMIRLERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5P2</accession>
    <name>A0A9P4P5P2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_437916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001518">
        <property type="protein sequence ID" value="KAF2437223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5P2"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2437223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="106" mass="11731" checksum="CFBC99601431FD47" modified="2023-09-13" version="1">MAGGSTSNGARHKATWHIGGWGNPYEGGGQPGKGIVTYSLSTNRQRPWAGFFTKGVWNSVRRVRNQVLYVVPPFILAYSAMQWAIERNEYLNSKPGRAEFADAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5X1</accession>
    <name>A0A9P4P5X1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_506297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5X1"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="153" mass="17266" checksum="8254BB499264D6AD" modified="2023-09-13" version="1" fragment="single">VLQHSIGPTWRTGTDQVVERAAACDPRAEHQSKKCTSPYGDTHLDHQQAATTAKLHGIPCEIQSRQSLYARPSRLEPAKTPYLDPVHRCILFPYRHRGHHTRHGRLPCGVGPMEERYYISGYVCGAINLASTSRYLKEHPTTPRCSWPLFLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P693</accession>
    <name>A0A9P4P693_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_180877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P693"/>
    <dbReference type="OrthoDB" id="3767399at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="544"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2437339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="625" mass="69246" checksum="7A511EADE955B382" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6I8</accession>
    <name>A0A9P4P6I8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_437303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6I8"/>
    <dbReference type="OrthoDB" id="3923199at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2438242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="61039" checksum="C75BDAC60E6F2ABE" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6J5</accession>
    <name>A0A9P4P6J5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_369969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6J5"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040118762" description="Tat pathway signal sequence" evidence="2">
        <location>
            <begin position="26"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2439299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27757" checksum="93552E1071EBCB6A" modified="2023-09-13" version="1">MVFVTILNVFLLLVSIVILSMSTKGSFSDQDYWRATSYYSPVFDRFNIPKLTQVTNGTFWNTEPPSIWRARTGAEADAAWESIGSNIAPIIINSVEVLALGKDPSVAVKAPPELNLGSDAYIAGMDVFHHLHCLDKLRREISYKHYHEAEEGPSPGSELHEAHINHCLDVLAQALKCTGSVDMVTFNWVEGHRMPQPDFNNKKVCRDFEALREWTVENGVDSDGFFKAADKPPPGAVIVPEFHPHNHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6U8</accession>
    <name>A0A9P4P6U8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_158708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6U8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="156" mass="16489" checksum="C547D95E17EC0F7F" modified="2023-09-13" version="1">MSPSGLGRRSRETRWTLDSPVGRNRAGDSLISSQLHAHRCYRTAKQSDQPRDFGPWATTSLANPASFLQMHASAAGVPRQPATQLGRDACTVSTQLAPACGSRLGVAAALGALHSSRRGGGYEGFFSSKPNEEDGGVAVRVLGLAEKLMSRARAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8S4</accession>
    <name>A0A9P4P8S4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_476597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8S4"/>
    <dbReference type="OrthoDB" id="3756818at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13013">
        <property type="entry name" value="F-box-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="32"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="442" mass="50230" checksum="3CA5E5B16ACC6EA8" modified="2023-09-13" version="1">MGITNSKSGEMVKRCISTPFSRPSGSSQQDTIARRLTFLDLPPEIRSHIYEYCILDSEVEVISKAKMSAKPFGDPSSLPRPEIRPNGISFAEYWQQMPIDESPAQQQCSWNIEPMEIYRKFVDNQTGNPGVGPTTSKRPGGGFRAFEASYAKSDRVQSLVVNLFLANKQICQEASILFYERNHFVFNTRWEDVHWAPLAFLWDHPGAYMWMRSLHITMPDPPAFVNHGRILRGEDALPSNGRWKDLVTQIRKLRLRHFGLTISVDVTDRISLGKINSPFSAAYTPQWFKILLPINGLQSMRLLFDVDLQYTNPNPALVTYMWPSDLPAVISMAQELKDHWLSGKGSYEDAQLHLCNSRIGAGATGHRLEFVSWVKSENPGAWVFPLQWLPPSLSRQDPTWYVLTNLTGHYQREHYTRPGFDRLSIPGLGNGEKASDVALRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P953</accession>
    <name>A0A9P4P953_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_422488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P953"/>
    <dbReference type="OrthoDB" id="2212170at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2438978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="128" mass="14021" checksum="B4A1C7084EF2DE79" modified="2023-09-13" version="1">MPTTGRCNCSSITVTLEQLPPKSVLCYCANCKRSGSGPCSIVYMLDRSAVSINDPKSTLKTYDDNDTKSGNTVHRSFCSNCGTPIYSSMAPDAPQLIVKGGLFDEYPEPNYESFPEARPVWIQLKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P9Y7</accession>
    <name>A0A9P4P9Y7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_115716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P9Y7"/>
    <dbReference type="OrthoDB" id="3710622at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="262" mass="29222" checksum="2932560AC7672CBD" modified="2023-09-13" version="1">MQSPEWKSRNSSFSKEQPTPPATVYQQDLSTWKTTTITVQSIDSGMLNGRRAWLVCLTLQFSCPHNDRFKKANIMLQFEPSEAGLASTAVVKRWAPQFLTGRRTTSSVEWTFEGSLTAGVDIPGSTVNANASLSRKESVVKEHSCSILSDTWKSPQLAEPNAVRFYIHENEQSRGGIPNRLNAVLVIQSDVACRGRATVETNGIKAMYARGHHNPIELQVDVSYQPRFPEGVKDFSTLSTVEWQMLATPTLQMNDNIVGFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAK6</accession>
    <name>A0A9P4PAK6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_435309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAK6"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="294" mass="31113" checksum="17A86A8B149591F2" modified="2023-09-13" version="1">MLTLDINSLFSVKGMVFVITGGGSGIGAMFAKTLATNHASKVYILGRRVPALESVASHFPEVIIPIQCDITSKESLSAAVSHVEKDSGFVNCVIANSGATGPDMYGLPKDRKPSLEEVQKYLWDTPMADFTQAYEVNTTACFYTLVAFLGLLGKGNESGVAKSIGVKSQFIVTGSIGAMSRRPGMGFAYAGSKMAIIHIVKQLSTMLADWRFDIRANCFCPGVYPSDMSQGLMGDKSLTEEGSISPEVVPLTRAGTAEDAGGALIFMCSRAGAYTNGNILISDGGRMSIVPATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PAZ0</accession>
    <name>A0A9P4PAZ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_447618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PAZ0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2440701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="229" mass="23867" checksum="20D581EFD7E532F2" modified="2023-09-13" version="1">MALAPLPKDVEWSTKRPGSECRRERGGRLVAPRGDRVATDRAGGHEQGMVPYAVGLSTAERTCSESLASVRNGGAAVSKQIDGRGDGAVDVGVAPHVLRSNHDATCSAWWGDGEDEGDGEGDGEGDDAGEAHAQGPLAPQQTVRCAVEARRLTLDGGVSVSRYSKLPGVSPRGPPAFPGFQARRDASDRHLEPSRSRNPDPAKADGDLHSLAQASLSASEPSQSIKDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PB77</accession>
    <name>A0A9P4PB77_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_393623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2440821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PB77"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF23">
        <property type="entry name" value="DNAJ DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15460)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="423" mass="49792" checksum="FC46B5610F4D3DEC" modified="2023-09-13" version="1">MAPSAVTEDYYLILGVTQDADLELIIKSYRRRALELHPDRNNGKQEATAAFQRLGRAYETLKDASERRKYDLIYPSIRKNNPSAQSTPKQSSHSDPKPQSSTLGEAAQIAALQKSIQERTARWRTTNTSFESSIFEMKRDIRRLENDITVLVNIAAAEVAEEAQKKSWTTWVLSPFYKKVEDSEEVKEQKDRARQERRIEKDMKERRLDAKKAVLANKEEELRIQKAIYEVANLKEEQVLGQIRMKIWLREDRQRREKEEAERARRAQQRQEKEEAERVLRAQQREQQQKKEREAAEALRKQAAKQAAEQKRRWEEAQRQVEEEFKRHRASYAYRFSEPTVPPPHTRTAPCRHDGWWPKVQGRTACPRCDETWTYLLQCPGCAMKACPRCQAAVRPSLRGQRRPRPRIRTPSPEPAYNYWDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PBW2</accession>
    <name>A0A9P4PBW2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_396381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PBW2"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF48">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2440171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="574" mass="65136" checksum="B40A4F54F0B76B58" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCH0</accession>
    <name>A0A9P4PCH0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Restriction of telomere capping protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_420319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RTC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCH0"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF130">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="334"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2440549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="618" mass="68383" checksum="74FB1126AF36C40E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCQ7</accession>
    <name>A0A9P4PCQ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate esterase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_497811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCQ7"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040319873" evidence="3">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2441527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="291" mass="30656" checksum="9641068536114188" modified="2023-09-13" version="1">MHLLSLPSLLLPLAVASALPGRSQDSPPTSSSTKAIPTIWLAGDSTTAPGGGHNGTEGWGQYLKYSFGDNAFVNNSAYAGRSARSFTREGRFDRIAAAMKPGDFVVIELGINDGGKPINGSTSTTGDKGRADCPGAGNETCTVVFNNVTEIVQTFPTYIETATRKFISLGAVCVIISEQLPTNVWESGSYSYKPSFFSYYDLLGGPAGKTYLVQHGSYAAQAQKLLGAEVVDANYPMDHTHTAPFLADHSQAFVLGLKCGTSPLANLVVNATARIEASRGPCLPANDTLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCV5</accession>
    <name>A0A9P4PCV5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_486674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCV5"/>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="77948" checksum="D501A23455511E85" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCV9</accession>
    <name>A0A9P4PCV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_446609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCV9"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="165" mass="19216" checksum="A1B2FDCC5E260864" modified="2023-09-13" version="1">MMNKDLQLANAADKFQKQFFVKAEQFKFNWGEPHYQDNRLIATLEVTDCYPIDKQHQWPMRAPLPRARPYDDVVETAATILLCEVKEAQEVQKAMIEALWKTFKGWEVEKEGVGFLFEAEDNWHAVINFKGAEVFRGIPSATKEAAMKALKREIVKKQKILRRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PCW8</accession>
    <name>A0A9P4PCW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_522435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PCW8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2442705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="162" mass="18067" checksum="C1030D7475D1F73A" modified="2023-09-13" version="1">MSSYSRWTKPELLQHIDQLHGHAETRLTEVDDLSARVRALEFDNKNLRELLAQHGLTAPKPTTAATFAFSAPVANVNNTVNNLTIMNTNPASAVNNAAPSQPTSDNEAPQVPLPKWRTVCKRELLGRCRRNACDFAHQYQRAAYGETRINALPKYSAKSQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDH4</accession>
    <name>A0A9P4PDH4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_321084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001504">
        <property type="protein sequence ID" value="KAF2441990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDH4"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="122" mass="13889" checksum="BF7CAF154F5BD98D" modified="2023-09-13" version="1" fragment="single">TGHRLAPHFLPYPGKPYEGLATSTTTDAAPIQDWVPTLNWVYLDAFSHQLKYGVQEDTESNIAGPFDCIPQSQHLKFQEWEGFCAVEIQPNRWTIYFDVDDDVLRGKVPPGASIVEIELERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PDN2</accession>
    <name>A0A9P4PDN2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_488371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PDN2"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2441942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="187" mass="21150" checksum="EFD208642CE57B72" modified="2023-09-13" version="1">MPDAVSHLPDDEDAVQYLAISHHAFPSKKPASPTNHGYMPFRIPRLADNAALNCLVTASPRITESRCASNERYSAAKRTAQHWRNGTFTWLSNHFICNASKQARVRLPAGRAIIAREKQTEASWPAGGLTLMRQLPFPVYTKRAWRRERPRNRSKYITLTMPRMRPASFTVEILAIDLRVKAGGSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEA8</accession>
    <name>A0A9P4PEA8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_393275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEA8"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2441778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="176" mass="20182" checksum="82137B1CC726CED4" modified="2023-09-13" version="1">MALARPLPPLWQTLLPGLNGPARPVLNLPLLQRLAQPFRMLPTPFAALAIPLSLPSIPSLSDIWEGLLKAVPKKKTSYMKKRTRFMAGKGLKDLTNLNKCSACGRVKRAHFLCPYCVDAIKSNIFGQHWWSVRVPTRKQEKQLKRQKREELMRSRMVVPDPREDKPIVEHTTWSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEC4</accession>
    <name>A0A9P4PEC4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_444898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEC4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="213" mass="24614" checksum="F1389064E5A07DD2" modified="2023-09-13" version="1">MDPCFSMRMSMDCVPLGCQNSDDNSECLLLAGQTAVYVEVWGFVWSLKLWGDSYMECPSPWHNLAKLDIMLAACGPKKSILRLICGRRVVPRSRQQEGYRAFRLETKIVRIDPLVHAPVAPPRSTEDVRKAELEAKLEEIMDGCPPIREGDPYIHITGKEKRHTEARKQLTQELFKELDMRCRARRRFKVEHDITWMEPNQYRVYDNVTTGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PED2</accession>
    <name>A0A9P4PED2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_362334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PED2"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040444671" description="glucan endo-1,3-beta-D-glucosidase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="7">
        <location>
            <begin position="325"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2443499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="463" mass="49453" checksum="9F5E9AEA2276A01A" modified="2023-09-13" version="1">MRVSSTLIAATALLSSAEAAYKGFNYGAFFGNNQAKVYNDFRYEFEAAKALPNTNGQFTSARLYTMIQHGTTKNVITAIKAAIDTNTQLLLGIWTSAGQTVVDNEIAALKAAINTYGTKFTNLVVGISVGSEDLYRITPTAAANGEKNPGVQPAQLVKYINQVRTAIKGTGLASKPIGHVDTWTAYVNASNSVVVNALDFLGVDAYPYFEVEHANSIGNANATFYDAYKQVVSAAKGKKVWVTETGWPVSGPKQNQAVASKANARIYWEDVSCSLMKGNVNLFYYTLQDIQYTTPSPSFGIKPGGDLKAVSPNFDLSCPKVSYTQYPNKAIGNSYTAQVSPTRSTLFVFDVPPSSAKTCNLVFVLPPTFDPTYMAPIQINSPGGISISRLDRPATVRTSANSVTGGKVVGAVPALQPGNKYTIASAPCEGGQHVSYKADSLNGLDLSFFQMTSPALGLFMEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEJ5</accession>
    <name>A0A9P4PEJ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_522415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PEJ5"/>
    <dbReference type="OrthoDB" id="5307331at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2442681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1018" mass="115749" checksum="A600891BE497F12C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PEZ3</accession>
    <name>A0A9P4PEZ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">P171DRAFT_432961</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="878"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
        <location>
            <begin position="1056"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1408"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1498"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="705"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="759"/>
            <end position="775"/>
        </location>
    </feature>
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            <begin position="1463"/>
            <end position="1475"/>
        </location>
    </feature>
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            <begin position="1500"/>
            <end position="1509"/>
        </location>
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            <begin position="1535"/>
            <end position="1557"/>
        </location>
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            <end position="1628"/>
        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF2443784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1818" mass="192818" checksum="1EC3E117A92553F0" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFB3</accession>
    <name>A0A9P4PFB3_9PLEO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_363035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAF2442965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PFQ9</accession>
    <name>A0A9P4PFQ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
                <person name="Labutti K."/>
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                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
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                <person name="Daum C."/>
                <person name="Ezra D."/>
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                <person name="Crous P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2443296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2443296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="116" mass="13097" checksum="A5229C0BC827264D" modified="2023-09-13" version="1">MMSCKVSISTSPRLHNQALRGFRHSIFRRLRVTSRILHPALEITPCQPSVRPKANADTLLVWGSPSDVEPPLIQSNNRTSTMPANVTVCETARILYRVDMFLARDEGQLEERLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A9P4PG18_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_433099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="197"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="741"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="783"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2442678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="898" mass="99841" checksum="992ABB3CF2C10BF5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PHE5</accession>
    <name>A0A9P4PHE5_9PLEO</name>
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        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_455348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAF2443383.1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="227" mass="25429" checksum="9F2020676D89662D" modified="2023-09-13" version="1">MDKLAIPPPDRAVFLAVNKLVLDYMYGERYDPSHDYEHIQRVVKYTHELYHLEQAAGRLPPTLDPTTMYLAAMMHDVGETKYLEKGRTQEDVVTEALLSCGATPALAHAVATIAINVSYTREKNAHDHTLLHAVIAAHPELAFVQDADRLDALGPTGQARCFVFGGANEARRASSIHTGVQLHHTRFRFYVGMMKTRAGREMAGGKWAWMRNFAREWARDTDVGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1392251"/>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2443668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="232" mass="25141" checksum="8211AE5EDCBC00CC" modified="2023-09-13" version="1">MPPEYNGRSSKNPSRSSALASADASAQASKEDKRNLKCAFASPISEVPYRGLGFLLNTPRVSGRPGARSRAARKVEFALDSPAPRVSSRYSTFPVQARRASEKFGALLARARSALGRRAARNQNARKLKCALDSPSSKVPSRYSTFSIQAPRTSGKFVARRGALGRPEARSRDIQKLKCALDSPAREVPDAYSTFLAQALGASGYCVASGARRRAPEARWGAKQRPVKIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIM9</accession>
    <name>A0A9P4PIM9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDHD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
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                <person name="Bloem J."/>
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                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIM9"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
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        <property type="entry name" value="PA-PLA1_DUF7131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23465">
        <property type="entry name" value="DUF7131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="856"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114147" checksum="36A2F651BB1ED081" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIR1</accession>
    <name>A0A9P4PIR1_9PLEO</name>
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        <recommendedName>
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        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_432144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
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                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIR1"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2444058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="601" mass="67309" checksum="E22D9DF9250AFAE4" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PIZ1</accession>
    <name>A0A9P4PIZ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_520923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2444822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PIZ1"/>
    <dbReference type="OrthoDB" id="3795156at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="299" mass="32465" checksum="DE1FF25F1DA1AFBE" modified="2023-09-13" version="1">MSSGTQANPIELFSSSEEESDFSDAETRVDTPPSGTKEDPITLASSEDESSPAPVSPWGSSKRPITLDDSDSEDEPPTKKRSPSPPRLDLALAIPATAQQPPPLLHHHPAAATTTTTADPGGNFVAPTIAKSARLAALLRACPSLHVAPAPLPAHEQIIHEMRLARNRMATETEGGAFLAWRSFAQPSRGTRECMVQSGLDPEDLWDEEFGVENMLPRWKQPLTSGWTLRGEAPMERRTPSLSREPSVFGEGGDEDEWVAVESENEEEVVVVEDEDDEDEVVILKVDGGDEGYEGDVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PK33</accession>
    <name>A0A9P4PK33_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_520396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PK33"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="498" mass="56691" checksum="67AF67DAC772372B" modified="2023-09-13" version="1">MSSAVINRLAFLLPALFLFYVFLRVFYNLFLHPLRSFPGPFAARATILASQRHTLKGEFPYWLHELHLKYGSIVRFAPDELSVIDSAVWKDVYGHRTTKLFTKQESFYGPDYYGNPAGMIRADNESHAKQRKLVSHAFSDKALKEQEQILKEYAKLLVKSLTAASEQHGEVDMVRFYNYTTFDIMADLTFGEPLGLLQGSTYIPWVAALFGSIKFLSVTGVVRRWPLLDNLLQRYLPKRLKEKRREHLQFSSARVDKRMQKKTDRPDIWTYVTKEGKDENGETTGLLPSQLHSNASTFMTAGTETTATELSGITYYLYQQPEKLSRLKKEVRDAFASVDDMTMTKLSQLEYLNACIEEGLRVYPPLAGITPRNTPSTGANVAGRWIPGGTIISIAHYAAYHSPANFRNPDSFVPERWLPEGQQEYGSDNKEVFNAFSYGPRNCLGKNLAYHEMRLVLATVMFSFDIELIKGAGDWVRQECHILWAKPAMMARVTPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKA2</accession>
    <name>A0A9P4PKA2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_272557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKA2"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2445741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="805" mass="88979" checksum="495ECD3441196E6D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKG3</accession>
    <name>A0A9P4PKG3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_444715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKG3"/>
    <dbReference type="OrthoDB" id="10678963at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2444569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="564" mass="61123" checksum="E121A945FD214809" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKJ1</accession>
    <name>A0A9P4PKJ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_429719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF22">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="6"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="913"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2049"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="913"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1063"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="945"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2446770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="2138" mass="233625" checksum="C4D515C5DEA45578" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PKL0</accession>
    <name>A0A9P4PKL0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_485089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PKL0"/>
    <dbReference type="OrthoDB" id="10596359at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2445018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="696" mass="77689" checksum="86D1E3670CCD856B" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLG3</accession>
    <name>A0A9P4PLG3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_410124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLG3"/>
    <dbReference type="OrthoDB" id="3928876at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2446127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="268" mass="29474" checksum="7250A0593F728748" modified="2023-09-13" version="1">MSSLVNSIQSILGKLWTNTANGFNKILPPDKRAELLSKFQDFANSNPKLAVSPLLFFPFRIPHCFIAFLATHVFLTGIPILLFTLFSISVLVFSLVTALLASILAALFFTFFMVGVALLFLVPTLFLTTFTASFVFLWGLVGFYVLKWFTQGEGNASDGKSVSEKVDRFTGGRAKRVTSGVSEKQELTHIGDDKEVRAHADDHDESDGTATERELEKVTESLRDDITHQSNRSPVKILKIVEGDENAADREIPAVPTAKETVGEAAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLK6</accession>
    <name>A0A9P4PLK6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P53-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_290109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLK6"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000007">
        <property type="entry name" value="p53-like transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="77"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="77"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2445139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="524" mass="57681" checksum="5CA07A57E671A2F5" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLU5</accession>
    <name>A0A9P4PLU5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_270164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLU5"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2445663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="297" mass="33012" checksum="3E923E9E933D13DD" modified="2023-09-13" version="1">MSKYGTLVMGPAGAGKSTFCASLIQHLQNNKRPCFYVNLDPAAEDFAFDPDLDIKDLISLEDVMEEMSLGPNGGLIYCFEFLMENLDFLTDPLEDVTDEYLIVFDMPGQIELYTHVPILPDLVKTLMRGSLNINMCAAYLLEATFIVDRPKFFSGTLSAMSAMLMLEMPHINILSKMDLVKGQVAKRELNRFLDPDPALLEEDPTRKVQGDDAEEAKGYQDPGSAKSVMSGASFDKLNKAVAQLIDDFSMVSFLKLDAQDEDSLGAVLSYIDDAIQFHEAQEPKEPKDEFLETSMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PLV9</accession>
    <name>A0A9P4PLV9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_431951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001500">
        <property type="protein sequence ID" value="KAF2445211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PLV9"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF39">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="230"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2445211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="457" mass="49667" checksum="498D902250D7C1F8" modified="2023-09-13" version="1">MPLSTWVDTLRTEVEQYPIQASPDLDPSTYQGTYQMTGSASSIRGVNDSAVTYEPSEEAGLPSVDTYEPSADFEQDAALLQDPLFQPPSALEDLTIDDSIIAPSTMCSKSLPEPELGASLLAEFLVDFNTVYGLYRPNEVVEHIRICYEGLSDGTALAWASAYVVLGIAHRARAQSNVATPMDNELADYYLGRILPTVSGLLIAPPTLGLVQCLIGLAMLIRTSSHSQPSGIFISTALRIAQFLAYEQGDGGTASIQGVDVDVEQQRRVFWCAFTLDTDDAIFSNAPTTHRKDDLRAPFPAEDPPDALGSVAAAEGTWTVNLFALRTRLALLQSSAIDKVLSPSARSPNLDTAAHDILSRLSAWRDNKLFRHTPEQLLHLLYRSDVLHVLAVEASYFATVFRIHAFLLLGKNPLVNPFSADVLAILAAHKAHAAYPDAERLLAHLALIPHGDIGVCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PN79</accession>
    <name>A0A9P4PN79_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_255622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PN79"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2446238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="184" mass="19354" checksum="E93964193FC2A24C" modified="2023-09-13" version="1">MQSREYATQPVCFTTVHMASRVGACYVCEMHVQGGPGASRECKGARILTLAFVVDAAVGFGLELGANLVQQLVEALAGRASRRPDAGGIVVHGDGRTRSIASGGGVQLVAGARVSGRAGCFWQVERTGARGCRRTRRRVDRDGGRGCAKLRERCAAGWDGTDAQPGCSGGGERTWLWGCDEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNX3</accession>
    <name>A0A9P4PNX3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomeras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_430503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNX3"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2446339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="506" mass="55843" checksum="9DE7FC918DB14E77" modified="2023-09-13" version="1">MASTYNLEPHPTAKVVLHTTTGDLELELFAKQTPVTSRNFLQLCLDGYYDNTVFHRLVKEFILQGGDPTGTGQGGESSYDGEPFADEFHSRLKFNRRGLLGMANTGKKDDNGSQFFLTLANTPELQGQNTMFGRVAGDTIYNLMKMAETEIAEGSEDRPLYPTRVTSAEIIINPFEDMVKKEQVAQRTEPDTKKPKKTKRKAGKNLVSFGDDEGEGAESAPVAKKAKYNTKLVSAGAQTPSVLDDTPVPKVPKVPKEEKAIPIRRPRKSPSRSPSPRPASKPAQASPPRQKEPTPPPRELSPETEKQSKLDRVNAQIAELKASMKRNTGSQRAEPAKKKSLLDSMVPTSTTKGRKRGAASSAASEKTTLDILTKFKSKLESAAPADTKMKSPGLPEAVVEPADEANGSKTAADEEEVPCDLHFVMGCQSCTAWDKQDEEESDDDIGWMAHSLSFAKDRLGKDLEWKRKNEEDLVVIDPLEKAKEFKVDRKGKREWDNAKGKRKMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PNZ4</accession>
    <name>A0A9P4PNZ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_226383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PNZ4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="102" mass="11457" checksum="97D27F9F137F2274" modified="2023-09-13" version="1">MYSTLLSLPLPHLTTQTRSGCSHPKFSVTGFTLPYLFPLIHQHPTKYTFGRVRRLVISRIFHIVFAAMLLASTHYGFGTHGMDMVATGGDLRDARKVCVHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PPW0</accession>
    <name>A0A9P4PPW0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_429590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2448007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PPW0"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="108"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="203"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2448007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="301" mass="33016" checksum="D44A1ED8E6227581" modified="2023-09-13" version="1">MADAPKPLPFVYQFAAGAVAGVSEILVMYPLDVVKTRVQLQTGKATGEEGYNGMVDCFRKIIKNEGFSRLYRGISAPILMEAPKRATKFAANDSWGTFYRNLFGQEKMTQSLSVLTGATAGATESFVVVPFELIKIRLQDKAQAHKYNGMIDCFTKTVKNEGPLTLYQGLESTMWRHILWNAGYFGCIFQVRELIPAATTKQGQVTNDLISGAIGGTVGTIINTPMDVVKSRIQNSTKVAGTVPKYNWAWPALGTVMREEGFGALYKGFLPKVLRLGPGGGILLVVFTGVMDFFREMRGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQ27</accession>
    <name>A0A9P4PQ27_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">P171DRAFT_409658</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQ27"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 22" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 22" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 22" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 20" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 22" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF2447183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="198" mass="22052" checksum="17548F7FA2331462" modified="2023-09-13" version="1">MRSCWHIGIGADFSIVYDVLASLGLLNKHAKLLFLGLDNAGKTTLLHMLKNDRVAVLQPTLHPTSEELSIGNVKFTTFDLGGHAQARRLWRDYFPEVSGIVFLVDAKDHERFTESKAELDALLAMEELANTPFVILGNKIDHPDAISEDQLRAALGLYQTTGKGKVPLEGIRPIEVFMCSVVMRQGYGEGIRWLSQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PQP1</accession>
    <name>A0A9P4PQP1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">P171DRAFT_384270</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PQP1"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000697">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000525">
        <property type="entry name" value="Serine/threonine-protein kinase KIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="7"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="385"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="458"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="671"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF2447146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="731" mass="81593" checksum="2EE3021CAA4760D7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PR19</accession>
    <name>A0A9P4PR19_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_517383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PR19"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2449725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="332" mass="35926" checksum="6A8EF51F6D3F7627" modified="2023-09-13" version="1">MEVTYNIIKGSASKQLVESSVTAQLESHQVYIETTHSGLCGTDEHYLGADMALGHEGAGIVRQVGQGVKTVKVGDRVGFGYTHEVCAHCDNCAQGWDQFCRDQKRYGSHDFLNGTFSSGAVWDEKCVYPIPDGYDSANAAPLMCAGATVWTVLSRYGVVARDRVAVMGIGGLGHLAIKLAAAMGCHVVVLSSSESKRQEAMDYGASEFHVFRSGEKPVDTISPIKHLLMCGSGGVDYKSIIPLMDTHGAIYPLTVAFEPSPIPLLELVLSGIKIQGSLVASRDTMRSLLEFAARKNITPTIMTYPMNVKGVETAMQDLRDGKVRYRAVLCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PS86</accession>
    <name>A0A9P4PS86_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dibenzothiophene desulfurization enzyme A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_517859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PS86"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="26"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2448293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="473" mass="52366" checksum="B9D05D035AE08B1D" modified="2023-09-13" version="1">MAPKQFILNAFVEMCSGHQSPGLWRHPEDHSHEFGNVQHWVELAKLLEEAKFHGIFIADVLGGYDVYNGNLEAAIVSGAQWPVNEPLAVVSAMAAATKSIGFGVTCSTTYEQPYHLARRLSTVDHLSNGRLGWNIVTSYLDSAARNMGFKEQLAHDERYAQAEEYVKVMYKLFESSWRDDAVVLDRSKGVYTVPDRVREINHQGKYFTVPGPHICQPSPQRTPLILQAGASKAGKKFAAQNAEAIFVSAHAPEVCAKNIAEIRELAKTEFGRDGSNIKVLALVTPIIGRTEEEAQAKLAEYRKYASLDGALALFCGWTGIDLGKYGDEEELRQVESNAVRSTVEGYARFSPGTSKWTKHTVAEHVSIGGNGPIFVGTPAQVADSFQIWHDEAGVDGFNIAYALFPQSFKDVIELLLPELRARDLFWDEYAVPGGTYRENFYQKEGQSGPLDDHVASTYRWKAGVNAKDHVIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PST4</accession>
    <name>A0A9P4PST4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_481762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PST4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2448708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="124" mass="13919" checksum="32EAC12E70972F24" modified="2023-09-13" version="1">MKFHFIPNININYNCNIIIALILANLESSVVLNFVVVSISYNPYLFLLAPNLNFTTKLHHPYNPTYPNHSPPLSHDTYLTPQAFYQAFPHPWHLLVCLPATTAPRATSTVLSPATCSSYLYNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT01</accession>
    <name>A0A9P4PT01_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_146811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT01"/>
    <dbReference type="OrthoDB" id="4497018at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="501" mass="56722" checksum="EF74374F268A3F7F" modified="2023-09-13" version="1">MSSWLHRLRGEHVESNENRVEQPNVVERSKAKPRQRPVDHKPKDPNAPLKRLQLHQKCLYERAMPGNAFVSAHVNRLQHGYYESKALHEGPLNNMYFVSVHFVFHPRHHHNHRFRAATIKVSVHTDFTSSDFEPEKGRYKPLCSHPRILKHAPELIYGAVSPENLQWNFNLSSSLGSSSLAPLSATLNPSGGVKKTYRVYDMMSIQGSLRVLKSPLGSDFDVDDAMAVWTLEENLTQRSGLPREFDFVMLVHKPDDVRNVYLSIDLDATVSSWHGDYPQWYTNLSRYLPHVDYTLDLDTDIGQKFLPEKPGRGFNFADLPQALDQYVCMPGTMYPTADSKPDDVRSGDRNWSRYREYEPRGSVNDNRASGAAPAASPEPMSPEKQINTWDQPSGGAPASAPTPQRQFGLPETLNVRVTLEHTNSRSPATYRYSGSPISNQEPARRHSIRRRRSRSELKKYGVQQALQALAGDTLKDNGDLPTRAPKVARARSTERVVNGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PT88</accession>
    <name>A0A9P4PT88_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_481903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PT88"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF42">
        <property type="entry name" value="PUTATIVE SUBFAMILY (AFU_ORTHOLOGUE AFUA_6G13760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="282"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="789" mass="85985" checksum="B67BBECF87511C4E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PWD6</accession>
    <name>A0A9P4PWD6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_479247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PWD6"/>
    <dbReference type="OrthoDB" id="3739795at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2450134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="265" mass="27374" checksum="AE29EBF14AD22C93" modified="2023-09-13" version="1">MDFPASGPFSGLACTTTSPLGIAAIPITQLVQAATSDAISQLCDRPTDSMYQINPDSIAVSFSSELVDLTITMPPDGVAQGSATCQTAFSSIAAECFGWEGVWGGDFYDGDFTYAIARAASADSLVETLENRLYGQEAGVSASGFVTATVEASGSASGFPAPSGIVSGYPVDDFPFPTPTATAIASGYYPGPVASGFVPPFPSDFPIASGFVPSGVESGYVAIPTPEAPVFPGWSEDAFAKVRRGSGEREEVEAETRPKARWIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PX50</accession>
    <name>A0A9P4PX50_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_426825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="183"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="514"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1294"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="827"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1251"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1313"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1354"/>
            <end position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2450446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1375" mass="149226" checksum="229637EDA18CCC97" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4PZB3</accession>
    <name>A0A9P4PZB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">COPI associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_347229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001492">
        <property type="protein sequence ID" value="KAF2451631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4PZB3"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2451631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="125" mass="13565" checksum="6F884CCC3236E081" modified="2023-09-13" version="1" fragment="single">RMVNFATAVFMILGGVTKFIHPGGFANIILGVYLVIFEGTANRGAEFQIPPQVARYASFMFSFIGRGVFYVFVGSVAVGDGWWRIIPGTIVGVVGLAYVVLEFIPSMEPPANMRDADAGWGQEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U469</accession>
    <name>A0A9P4U469_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_449837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U469"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="118" mass="13003" checksum="32E3322FDDD0CC82" modified="2023-09-13" version="1">MIGSGRAIRDLAQRKRLLLNYVSQVDMPNQLHGSLICPAEGPACITVQRALPAALHCSKAVVATLGCITLLTTACAYRAYRTAYQSNAKLAMTGARAARRHRRFAVLAQRERRMPPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U529</accession>
    <name>A0A9P4U529_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_449838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001515">
        <property type="protein sequence ID" value="KAF2437630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U529"/>
    <dbReference type="OrthoDB" id="10483301at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="447" mass="50866" checksum="1CBBADAC2619B40C" modified="2023-09-13" version="1">MARSAQAHFHCLGSIQSTLFEAQVTSHSFSLPRNLNVQSSPKPTMVLTRTAKKMQQSQAGGDVDVGRDLDFISHEIDTQSNDLGQLSENLYVRTDVEDRYLDELSLQGDRISDALDRLHNRVDHVGNFPEWRAMRYDELDEAREMYSDVEDRLHSLRVPRHRARLQRRQQRTPSPQAHAVDALVEDLEGIQLDASDADSSGTVHEFWKTKAEVLERHRESLLKTFDVFKRHLDYKKTGVGKVIAFDCEFSPGKAQYAHIPWQIAAVDMSTTKAKVQAVTAYWNYGEDSNAVKNDIQDKVDAVDDEKMEAWLRKQAGTYSKRKTQQNMANGLTANEIQEEFRAAGINEHVLLITWGTTNADACAFAKIWAGNDDLLVETKDLDWERYIKLDVSQLIKKTSHLGNLSLKEAYMALFPDAPELDWHDALADATATANIASHIYENRHRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U5U4</accession>
    <name>A0A9P4U5U4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_437161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U5U4"/>
    <dbReference type="OrthoDB" id="3927839at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="225" mass="25410" checksum="8FCD51139572E3DA" modified="2023-09-13" version="1">MEAPMHTSTSHEATKSFDHDLVLSRHLSWEEEELNDPEKTQLADNDLDVHSDSDKISEYDTEHCPGVCVSTDDAPRAPTTRQANRQSHPLSLQSNVTHIQAEGVRAKVARSDAILEKISRQKMLVEEHATTQVVTRKQQKEVPKKAKAAKNTEVAKVVTHSRSHEQVPFCTHKVYWTQIPGRSRCEHHSYSPNSYRNPFRFKCPGCNTIACGLCMKKLKRGGMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6S1</accession>
    <name>A0A9P4U6S1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_396615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001509">
        <property type="protein sequence ID" value="KAF2439355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6S1"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040537860" evidence="6">
        <location>
            <begin position="22"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="49"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="8">
        <location>
            <begin position="350"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="563" mass="61072" checksum="C924B90CE3E952E1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6V8</accession>
    <name>A0A9P4U6V8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_476960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6V8"/>
    <dbReference type="OrthoDB" id="5430750at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1142"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1178"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="873"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2439176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1237" mass="139003" checksum="12F4A512E697D393" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U6Z2</accession>
    <name>A0A9P4U6Z2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carotenoid oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_436592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U6Z2"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2438653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="738" mass="82083" checksum="39587F18BA3E4AB7" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U886</accession>
    <name>A0A9P4U886_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_104323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U886"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000142">
        <property type="entry name" value="Regulatory protein ral2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="829"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1047"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="829"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1047"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2440616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1081" mass="115407" checksum="01D49642AD9CF3BA" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8D4</accession>
    <name>A0A9P4U8D4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_118219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2440078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8D4"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2440078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="264" mass="28561" checksum="5796702F85A9C61B" modified="2023-09-13" version="1">MAFSLKGVAYITGAGSGIGQYAAYAMARQGVRSFALLDRNPVTRTVQHLKKTYPDVNIKEFEMDVADEAAVNHSVEQTVKEFGRLDYALNNAGIGSALKTTDQIEKADFERVMSVNTTGVWLCQRAQIRQMLKQDKWSDSYRSYRGSIVNTASMYGKVGPTLNVPATAYATSKHAVVGLTKADAIAMAPRGIKINAICPGYVLTPLVEGTMDKGSVMDDERVKVPVQRFASMEEIGDVIAFLHSDASSYVVGSALVADGGFTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8M1</accession>
    <name>A0A9P4U8M1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_99082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="MU001507">
        <property type="protein sequence ID" value="KAF2440333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8M1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="319"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2440333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="529" mass="58101" checksum="F02BD866FF9C7DDF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U8U2</accession>
    <name>A0A9P4U8U2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA polymeras-like protein subunit delta-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">P171DRAFT_419495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001506">
        <property type="protein sequence ID" value="KAF2441261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U8U2"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="6">
        <location>
            <begin position="47"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="5">
        <location>
            <begin position="219"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF2441261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="496" mass="54296" checksum="0D634ED5C910225F" modified="2023-09-13" version="1">MASKDGILLRGAPFEDPAAVSSRDASAYRPLHTFELPKGSEKHYAHQFADMYFVRLAQLKEAVKQKAHEAWDAFELAGDKAKYVERVLDVRQGELCWVIGTVYMEMAMKPNVLDDISKEHWIAAPPLRETYVSSSGTDDMMLEDESGRLRVAGNSLNSHYVTGCILAALGTEQADGSFQVIATQYADLPRQPQRWEAEDASLTVAKQSAPKREKAGKLALVSGLDMTGKEEDDVTLDLLVEYLTGEAGGADQSSASSIARLVIAGNSLSNASPILSRDDFDVRKGAKRNYGYDSSSYNATPAEKFDAFLAEILPALPVSVLPGETDPANVALPQQPLHPALFPLSRAYAEPLAISNESLEGLDLVTNPWEADVEGWRILGTAGQTLDDLLKYVNGVRPLDAMEMMLRWRCIAPTAPDTLWCYPFQDDDPLILNECPHIYFAGNREKFQAKSVKGPAGQQVLIVGVPKFSKTGQVVLVDMETLEVETVKLGYVKPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U992</accession>
    <name>A0A9P4U992_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">P171DRAFT_488392</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U992"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="11"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="355"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF2441965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="467" mass="51161" checksum="8E9DD724B80BEEDF" modified="2023-09-13" version="1">MAPVTQTEECDYLVIGIGSGGIASARRAAKHGAKVISIESKRYGGTCVNVGCVPKKITWNAAAISETFKDARAYGFGGYDTPTFDWPLFKKKRDAYVKRLNGIYENNLNKDEIKHYKGRAKFVANDEVEVALNEGGTQRIKGKHILIATGGRPNVPDIPGAELCIDSDGFFELENQPKSIATSGAGYIGVEMSGMMHALGTETHFFIRGQKLLRTFDPMIQDTVTKEYERQGVHLYKGSQITKVEDIGNGLKRVTYQETESKKEGTLEVECVLFATGRSPEVEDLRIKDLGLKLNDKNHIMVDKYQNTNIGNIYAIGDASDSGFELTPVAIAAGRRLSDRLFGGKPDAHLSYENIPSVVFAHPEIGSVGLTEPEAREKYGDKVKVYKTEFTGMYYAMMEQGEKGPTAYKIVCVGEEEKVVGLHILGQGSSEILQGFGVAIKMGATKKDFDNCVAIHPVSAEELVTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9T4</accession>
    <name>A0A9P4U9T4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_71755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9T4"/>
    <dbReference type="OrthoDB" id="2122308at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14326" checksum="148A638F27A4B1BD" modified="2023-09-13" version="1">MTRSHKFTDRDHAGLADGSAHPEEHLPRYFAKSGNTGEDPNKTKKNGGGKGNWGQAGDEVEDMGYNIANARRRSNSSTNPTRDFKTKFETIEPEPVFEEELHGPMGAELDKESTTSSSNTVEEEDASKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9V2</accession>
    <name>A0A9P4U9V2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">P171DRAFT_434278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9V2"/>
    <dbReference type="OrthoDB" id="4776947at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040374379" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF2441623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="16052" checksum="DFDE41A347D969A9" modified="2023-09-13" version="1">MFSKAFFAVAFAAVASVASAASPPGCLLGAVNTYDTPSDIKAVCSAKDITTQISQKCGKKAEDALAALADICNDAGVKVSTKLPTSASGTASGTASPTGTGASSKSSATGTAHSTGSASPSSSSGTTEDAANSPSGTASSQPAENTGAAGALEVSAAALLAGLGIFVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4U9W3</accession>
    <name>A0A9P4U9W3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PNK3P-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_366243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001505">
        <property type="protein sequence ID" value="KAF2441653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4U9W3"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01625">
        <property type="entry name" value="HAD_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002548">
        <property type="entry name" value="DNA kinase/phosphatase Pnk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2441653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="447" mass="50281" checksum="F8FFFFFD88BA8DD7" modified="2023-09-13" version="1">MPERPGLGKRPSSADRGVSPPPAKRKQQSTTTNKAVANFFTPLSKKEPDQMAWRVVNDSLLIGRYRAAAHLPKATNAKRKIAAFDFDSTLITPASGKKFGRDATDWKWWHRSVPHKLRQLHEDGYLVAVLSNQAGISLKPDAKTIKSDQKRLADFKAKVSAVFAQLELPISVYAATSHDRYRKPRVGMWEELREDYDLEKAEAVDLDNSFFVGDAAGREASGSRTKDFSCGDRNFAANVGIDFRTPEEYFLGEDPSPFTREFDPTAALRKAASRLVVTKFQRAESLEIVLFCGSPGAGKSSFYWRHLQPLGYARVNQDILKTREKCMRAAEELIGEGTSVAIDNTNADIETRAHWTALAKRLEVPIRCVVFTASSGVCEHNNAVRALNAGHDTNPEQRLLLPKLAFASFKKKYREPAMSEGFRDIVRVDFQFEGSEEQRKLWSMFWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UAB2</accession>
    <name>A0A9P4UAB2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">P171DRAFT_51156</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001503">
        <property type="protein sequence ID" value="KAF2442866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UAB2"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="177"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="11">
        <location>
            <begin position="474"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF2442866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="70267" checksum="6BFCFE8C50260A5E" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UBN6</accession>
    <name>A0A9P4UBN6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_432741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001502">
        <property type="protein sequence ID" value="KAF2443498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UBN6"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2443498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="242" mass="26175" checksum="929A62DBE960D063" modified="2023-09-13" version="1">MAEFIEKIAQTPGLKAVFNYENFRLQPAFDAKAQAAFIRPNEKLDNAFKNSLAKGLPPISVLPMAAQHLSVLTRLVGAKSVLEIGTLGGYSSIVFAQAGAKVTSIEISPKHRDVALENVSGLDVEILLGAALDVLPKLAEEGRKFDLVFIDADFDDQWEHFDWAVKLSRSGGGIFLDDVVPTMIKNGEVGFGGGGEVVEKRSVMERIGEDARVKASFLPVVAHMQPVLPDPMMNGFILAVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCN0</accession>
    <name>A0A9P4UCN0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_432397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001501">
        <property type="protein sequence ID" value="KAF2444337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCN0"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="299"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2444337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="515" mass="56252" checksum="99C25BBFEB9C9980" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UCY1</accession>
    <name>A0A9P4UCY1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_430138</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2447229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UCY1"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="12">
        <location>
            <begin position="62"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="349"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="696"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="790"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="902"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2447229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="1110" mass="125920" checksum="A1EA715C691C91CF" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UD28</accession>
    <name>A0A9P4UD28_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_470666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UD28"/>
    <dbReference type="OrthoDB" id="3794448at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040184812" evidence="1">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="225" mass="24802" checksum="3704C34D111B9A4F" modified="2023-09-13" version="1">MKYSSSILSALFAASVLAAPVPAPGTEESSVDQAFVNVAYYGLKEREAEAKPVPESATVDADFIGIVYNGLKKREEEDSSVDQAFVNVAYYGLKEREAAEQAKRGEQESDVDQAFVNVAYFGLKEREAAEAAVKRGEQESDVDQAFVNVAYYGLKEREAEAERVKRGEESSDVDQAFVNVAYFGLKEREAEAEKAKRSEEESSVDQAFVNVAYYGLKERDAEVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDL9</accession>
    <name>A0A9P4UDL9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_453094</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDL9"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000103">
        <property type="entry name" value="Mitochondrial glycine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="116"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="223"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2447979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="320" mass="35067" checksum="4EE0369C6AFA6A4E" modified="2023-09-13" version="1">MSNGSKSRSSSSFHFFAGMSSGMLSAVLLQPADLLKTRVQQSHQNTLLGTIKLIASGPNPIQQFWRGTLPSTLRTGCGSAIYFSGLNALRRRVSEASLLAGDRTRTDGHSSTLPKLSNTANLATGAVARTWAGFMMMPITILKVRYESNLYAYSSLLSASRDIFRTEGFRGFFAGFGATAVRDAPYAGLYVLFYEQSKRRLSRLATTIEETSGTSTARLSNSTSAGINFLSGVMAAGLGTTFTNPFDAIKTRIQLMPNRYTNTIQAGKKMLREDGMRSFFDGLGIRIARKAISSALAWTVYEELIRRVEGRWREGIEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDR6</accession>
    <name>A0A9P4UDR6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_443301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDR6"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2445673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="143" mass="15471" checksum="4890949F3D1CD404" modified="2023-09-13" version="1">MIVGDYLYTWLRSTAAHSAGESWGLFVQCHKFQLLFGVANWALDPTKYYLFWSIAGRILSFQRATAHNGAGLRKAGRNLLFRLTNCGGPLAVPLPVAVSKPPYGIPGIIGKTNNIDLAEGTIVSVAGSQTAQMFCAVSCQSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDS8</accession>
    <name>A0A9P4UDS8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_440593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDS8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2448159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="219" mass="24328" checksum="DE7BF6D6CFE3AB45" modified="2023-09-13" version="1">MSDEEKKREKWQLTQIFVDAIKDLLYNYKEKGMDPRVGNADIVIGPKDVALLHKMNCTRHPAEAQIHISNLNNFEVTIWGTDCENASDRLRSSLMNILNFNVDVLKDAVCAWDRDKIELQPGSYDQADDTKHHFSIADRLNIATEPKTEGHTAMVVTFIADIPTLNVDIIREMSMSPPSEDVAASEEDAGGASDENAEETPKGTLKGNVGKALQMAIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDW5</accession>
    <name>A0A9P4UDW5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_238622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDW5"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="328" mass="35624" checksum="4ECE82AF96AAEFAE" modified="2023-09-13" version="1">MAQKAIDLISVSSDIGSMYAGKSRAPAAFRSAGLHTKLNAAGFEVTEYSALTSPAIWKCSTREPNGARNEAATVAAISQVSKTITDVLNEDRRPAFHLILSGECLYIPAILSADWHYLRPTTRKIGIVYFDADADLHTASEPGGSGNIAGMTLTHLTLRDGALDGMKTFCRPDGAGVVDERNIVLFELNTLSEANKREHLGHLFDNDFRVFTSAAVQRDPEESAEKALEYMREHGVDHIIVHLDVDVIDPGEFPLCNVPSWTGLGYAQTMRALKVFLGSEQCVGLSVAEVNPDHDPGLVMTARLVDDVVDGLGKRRVHAALPWVGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UDY4</accession>
    <name>A0A9P4UDY4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">P171DRAFT_431282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001499">
        <property type="protein sequence ID" value="KAF2445898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UDY4"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF2445898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="197" mass="22281" checksum="CCA94A5818EC7436" modified="2023-09-13" version="1">MANQTCIICNGSNAKSCSSCHSISYCSQKCQKDDWSLHKTLCKTFTTLPPRPSPSHKLAILFPVDSKDPQLIWIECKRRVDDEDGVEWESPDTQNLLAIENLDPKYGNPREFKKITRSKLRGFNLSHTVEVIVRETGLIDGSTSNVCVQHTTKGRMTHDWSGPLVVMRQPGIAVDPLFYEDVRAGDFRVAVDYFLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UE82</accession>
    <name>A0A9P4UE82_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_508821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UE82"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="10">
        <location>
            <begin position="38"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="253"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF2448624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="429" mass="49063" checksum="1748C8B8EB69CF6A" modified="2023-09-13" version="1">MASVIGPGRVCHTQRPPFTPTRPWLIRFRRWVQREARPISLRRLTFFGRTLTQSRLLDGANYCRLELPTRIAHRLRDIQTLPYVVVANPHLAHVYELYLTAFERFRRVPEIRTLDDNERYCKILQETLTEHATVIPRLALGVLEVRGLMRPEETDKFMNTMLRSRISRRVIAEQHLALTDTFNSPWHFPHNQPEHDPHTDTVGEIFLKCNAKEIVQRCGKTTQELIKAAHGSHVHLPDIRIEGHLDATFPYIQSHLEYIIGELLRNSIQAVVEKRKYHGAKPPPIEVLICETSQHVIIRISDQGGGISNEILPHLWSFSKGPRHQKRLQNLARVPKLLGTLQELKMPGTQASKDHDKHDGGSSLSSLTSRPPDLRLGIGLPMSRVYAEYWAGSLEIHSLEGFGVDAFLQISKLGNKDERLTTRASMDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEA9</accession>
    <name>A0A9P4UEA9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">P171DRAFT_519282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001497">
        <property type="protein sequence ID" value="KAF2446945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEA9"/>
    <dbReference type="OrthoDB" id="5427633at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21789">
        <property type="entry name" value="Rad21_Rec8_M_SpRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF70">
        <property type="entry name" value="RAD21_REC8 N TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G02900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="669"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="691"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF2446945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="706" mass="76565" checksum="DA4D30B883F32D9C" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEL8</accession>
    <name>A0A9P4UEL8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">P171DRAFT_357747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001498">
        <property type="protein sequence ID" value="KAF2446347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEL8"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF2446347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="257" mass="29402" checksum="08E6173F491F101D" modified="2023-09-13" version="1">MADALAAGGGMVGQFPLEQWFYEMPVCTRWWMTAALSASLLVQCRIVSPFQLFYSFRTVFVRSQYWRLITTFFYFGPFSLDLLYHIFFLQRYSRLLEESSGRSPARFSWLLAFASTLLLCMAPLFSMAFLGSALSSTLVYIWSRKNPDTLLSFLGIFVFKAPYLPWLLLCFSLIMHGTVPKDEMCGIVVGHIWYFFNDVYPPLHNNHSPLDPPAWWVRLFEGPPPLPEPTGEDLTDLTGQPVDGTDVEPELIPVPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEQ0</accession>
    <name>A0A9P4UEQ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_469290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEQ0"/>
    <dbReference type="OrthoDB" id="2896006at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41173" checksum="2EE3825228C54EF8" modified="2023-09-13" version="1">MIQHITRRAVQHVPAFLKRAQEEPQLQMPAWGAAILIVTFIASMLAVTLVQYTLTDVLPILAMVETPAAAITISNHDEPASKDEKEGLLETGTEITLVHQKPITSSIRGTIRHLVSEAGKFSRWRGFRYQMIYALALGWTSSLLEAVFPRFMPVSTVVIAAISGAATANLHAAWTHKVISSPSDVSFWSRIPSRKEWKVLALPAAVAATMPYISLFLSLGFVSWFGIPKDMNSNDFANYNGGQWASFILRCVAVLAISVCCTLFLCMPAVVTQIRVDASILPEDQDVIVPFDRTFGGKVVPKVLGGTGCVGFMDAWRSFNWEARRRLIKLYIKGFMCLAALGFVIVHVLALEVFVIMGPEVGRYLAEAQKQGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEU4</accession>
    <name>A0A9P4UEU4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_429433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEU4"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2447831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="179" mass="20452" checksum="2D43BD13382A3EFC" modified="2023-09-13" version="1">MWSVAREDFLCRERPQLGEERKSVVPRAAHRTMLRIEHSDARLISFLSEAEEAVGMIKTYWEEAASTSMGMSIVFIAWRNRFLASLAGCKFRRARSSLSLSGSSLNEVTYTKYAKTVVQYAHEENKSSASIYNRFLEGTEVTAVTEALHRCCRDKVRTHLEPSHNLAKLFPVHIKWAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UEV3</accession>
    <name>A0A9P4UEV3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_509762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UEV3"/>
    <dbReference type="OrthoDB" id="10423002at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="338" mass="37671" checksum="682A2DDD4D32CB58" modified="2023-09-13" version="1" fragment="single">RDKPQSPLNSGEFVPASNIYTPTDFSTSHKNQPADPISTALEYKHVFQTLDSHSNDQRHSVHHAFSAQASSSTATQHPILQTQPSRKHIPRKITAPMAHPLTNNLTNESTTSPHLLALEIAILSYPYSSPRLPTASKKRLFTILEQRRAQALGIDPDLFVRALQSARREWRAHWDVWSPLVTQPVFPADREGDDEETRAEKRRARRATLTRFAAEVVVLEWCVVDAGLEAEAVRTVVGTIEKCRGLGRGVHRGEFEEVLEETRRVWVGHWMGWASVDEGGSVEYGVLSGSGAGELMVGRMVVTEKTGDAEEGLIEREVLADRVVVEYARVRAEVCGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG08</accession>
    <name>A0A9P4UG08_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 phenylacetate hydroxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_408240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG08"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="517" mass="58554" checksum="BFDF6C6227C7A736" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG43</accession>
    <name>A0A9P4UG43_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_482596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG43"/>
    <dbReference type="OrthoDB" id="3706179at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040245931" evidence="1">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2447892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="117" mass="13179" checksum="7910DC72D097CD18" modified="2023-09-13" version="1">MRLFVPLAMAVCVAFAAPIGDAPPPDNTPLCGYVRMEEDAWWSVGLQTHGRCESIWENETALIYRIDREGCGCAFFRDEDACKGQGDLVLHRGPKLEESRFMEEEKPTWALCQQIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG53</accession>
    <name>A0A9P4UG53_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleolar GTP-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_518941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001496">
        <property type="protein sequence ID" value="KAF2447922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG53"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000006">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000844">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="183"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2447922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="530" mass="58937" checksum="BB259E8951B499EC" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UG54</accession>
    <name>A0A9P4UG54_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">P171DRAFT_352434</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UG54"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004970">
        <property type="entry name" value="PRK06333.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="10">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF2448178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="429" mass="45614" checksum="56F4EF24CC900F03" modified="2023-09-13" version="1">MRKVAVTGLGLVTPLGLGVRRTWSRLLDGHCGIVSIKDRSPHFAALPSQVAGLVPEGKKEDGMWSPKDWLSASDERRMARFAQYAMVASEEALNDAGWAPKKEEDLEATGVYMGSGIGSLDDVYETTIAYEKGGYRKVSPLFVPRLLINLAAGHVSMRYGFKGPNHAATTACTTGAHSIGDAARLIQFGDADVMVAGGAESCIHPLAISGFARARSLATDWNDKPTEASRPFDKDRAGFVIGEGAGVVVLEELEHAKRRGAKIYAQLAGYGLSSDAYHMTAPRKDGQGPRLAMKHALRHAGITPSAVDYVNAHATSTPLGDAAENRAIKELLLGEHGKSKASDINISSTKGAIGHLLGASGSVEAIFTVLALYNNILPPTLNLHMPGDPPEDFDCNYVAHTAQQRDVRVALSNSFGFGGTNASLCFTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGI1</accession>
    <name>A0A9P4UGI1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_508429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGI1"/>
    <dbReference type="OrthoDB" id="3798874at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF8">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040434757" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2448267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="31832" checksum="8E5B60B9C3513DA7" modified="2023-09-13" version="1">MRPTSTVIQGLVLGLWVGSVSADCYAHDGVLAKNSAAYNEDFEMVSCGNGTNNCCFQGDKCGSNLLCYDNNGNTARQYCATQNWDGCSSLCADFAPRTGTLLVDCGKNMYCCGAVDETCCDDDSEHFFVDPLNGDVKHPSKATGSSATASPTWWTVDSKALLAATSTSSASSASSATSTSESNTESSASTTASTTASSTASSTSTPPPEEDSKGISAGAGAGIGIGAAAGIALVAGLAWFLIKRRRGKNVYEAPVGQQHAGGAYGAAAYPGEAKPVGYYAHDAGQSGQAHGLPPQELDGGAGRAEVHGESTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UGU6</accession>
    <name>A0A9P4UGU6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor tfiiic complex a box associated subunit sfc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">P171DRAFT_353272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001495">
        <property type="protein sequence ID" value="KAF2448612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UGU6"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="225"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF2448612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="72497" checksum="615697CFC2D93596" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UH62</accession>
    <name>A0A9P4UH62_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_480899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001494">
        <property type="protein sequence ID" value="KAF2449840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UH62"/>
    <dbReference type="OrthoDB" id="3668008at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2449840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="68392" checksum="848D1B366E79BFF1" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHM2</accession>
    <name>A0A9P4UHM2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">P171DRAFT_349860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHM2"/>
    <dbReference type="OrthoDB" id="3032304at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="309"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF2450380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="506" mass="56747" checksum="044918606A09F670" modified="2023-09-13" version="1">MASFTRIADEESPSIIVHPDHKVAKINDNIYGGFTEHMGRCIYGGIYDPGNPLSDENGFRKDVIEAMKDLNVPVVRYPGGNFVATYHWLDGVGPVENRPKRPELAWLGLEPNTFGTDEFMKWCEAVGTEPYLCLNFGTGTLDEALGWLEYCNSTQDTYYANLRRKNGREEPYNVKYWALGNECWGPWQVAQLTKEDYAKKAYQWAKALKLLDPSIVLILCGETGYSSWDYYVLKECVTWSVHGLGGDRTKSLIDMHSIHVYTADKEHLANATAPRGAERAIQMASALIDLARIENGVPETVPRQTICFDEWNVWDPVRAPGELGAEEKYTLSDALAVSVWLNGFIRQAKDLGMANIAQSINVISPLMTNKDGIVKQTIWWPLLLFSKYMRGHSVAVNVRAPEYTGRTNPAWIRAAIETPYLDVSASISDDGYVSLAVANVDEKKDFDVKVEGVKKGEVKVFTVGGENVDVVNTSDEQNVGIKESTWDGEGNFKFKKHSFTLLKWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UHY2</accession>
    <name>A0A9P4UHY2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septum formation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_451164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UHY2"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2450695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="290" mass="31459" checksum="5AB5E7F35EC7CE2F" modified="2023-09-13" version="1">MASQAPADPPPSYEELPNIPTPLNASATPLSASATPNAAPEPSPSPRRPPGPPPLLPLDIPALNQVRHKRVVLASTSPRRKQLLSILGLKNVEIIPSTFKEDLSKSLSPYEYVLETASEKCRQVYSREVDNEEKGEPALVIAADTIIISSKGRILEKPRNPQDHLDMLKMLRDEGTHKVATAVVVMKPLENPIDPGYAIESHVEITSVKFDANVSDATLVAYVRTRDGNDKAGGYGIQSAGSILIEKIEGAHDNVIGLPLRVTLGLIEKVMVPEEGLDDNMDNMFADEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4UIS0</accession>
    <name>A0A9P4UIS0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_142510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001493">
        <property type="protein sequence ID" value="KAF2450592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4UIS0"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2450592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="158" mass="18025" checksum="8841931B4954DE6D" modified="2023-09-13" version="1">MRQMPRHVVPRCNEAYLSRWLAAGNAMDSLCVLTILFYAVSHAHYLSRIRLWNGLVLFQTSARRSRSVIAPQGTRQCPSHTTRPSALSCIPTSPTSRASLCVKKNFDLWLVFRQTSSRHSETPNVTATMTHSMEHHHCQVLRSDMVACRSDKITEFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P501</accession>
    <name>A0A9P4P501_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_491141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P501"/>
    <dbReference type="OrthoDB" id="5399926at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="20107" checksum="1B897316772B66A6" modified="2023-09-13" version="1">MDIVVQPPSNARAGYSINGTIIVRLRTTNPNPNAATEDALNLAAIASLVPGPGSTVSSDPTVLNTLLSGRRVDNIHTLADDEADGSIASMELNDSQAVGYMRFSGLVIRQAGTYRIRITLLRMRNSSSDPPPASMAGAAAVQVVDSNPIVVQAGGPTAYNAWAFKWHEGTAVRMSAHGENVLVSALGLGLDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P5U1</accession>
    <name>A0A9P4P5U1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_174447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P5U1"/>
    <dbReference type="OrthoDB" id="5381672at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="430" mass="49254" checksum="0D6CB9EB4BD47633" modified="2023-09-13" version="1">MNLIGLEYDSKRWSFDRRTLDLRSLLESPFTSNDDINNWGVPYHLPHADYSTRTVRISDAGPIYAPLVNNFTSGVFPFPQFAPRMNSLITFEKINEDVFRENCRNETENVGFYARYYYIEPSSYGSSGWRNPDVDFKVCMTNDLRSSPWNTTRDRQDLIEELYYKTFDPIKAPYLTYWKITSTTSLGYFEVPSSQNGYVPGPLLDKDPFIDDKVQIANNRISNYDERHLLRRLENLTYSGNATMNRSGYHKSPLASVAIALFGPYSFIDTRMSNPSNFVVPDDPDRNLRFDAITSNCVYKAPLFDLLSSPKGCISQYDSGTASSVISQVSSLLYYFSSQQQENIVPVLSNALYMASKIWLPQRVAGLRSDDTQLRVYFNKGTPTKKPKISNTGIILVRCFSAYIYWGCCCWYVTLSERSHGQAGWAQRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P683</accession>
    <name>A0A9P4P683_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_180449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001516">
        <property type="protein sequence ID" value="KAF2437324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P683"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="234" mass="26398" checksum="523A2246180F10A0" modified="2023-09-13" version="1">MMSARDMRQRMKLRILFPCISYYHDKRSATRNHGSPRPPLVYEKVYTIFHWVVGLISRCTYAHDPAGIDAILILVSGTRSMTRRPAWTGLHADLASLSERHLPYDLEKFISGTAYGECYGTMARTRYACRGPTKAMSTRSNNNGDPCCILRGLMRSHNTQKVWTRELHSFFGRQSAKYCISPSGHSAYSTLDGKKKKARLYTAYSLLEIRTATRRAVSTKPQEFAAGDLCTGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6H0</accession>
    <name>A0A9P4P6H0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_399102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001513">
        <property type="protein sequence ID" value="KAF2438212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6H0"/>
    <dbReference type="OrthoDB" id="544277at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24502" checksum="3C6C123311380FA5" modified="2023-09-13" version="1">MSTELEITKPLRKITDPSDIPRFAALVAAAFSQDALNRYLFLGRESNPEHPKIETLEFRTKYWETIVRPRFESGAILVESHDWAAIGLWFPPGVEKKPTPASTLSEGVTEYLTFFKALREEKLGARPHWHLNIISRDPKRTDKGAVSAIFEPFLAEAKANNIPVWLESTNAHAKGVYEFFGFKVVGSTRIGKGIVGSDGWAKEGGEGVETWGMIAGLDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P6W6</accession>
    <name>A0A9P4P6W6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_526050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P6W6"/>
    <dbReference type="OrthoDB" id="3554680at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2438357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="59242" checksum="AA43FC4424E7AA6D" modified="2023-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7K7</accession>
    <name>A0A9P4P7K7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">P171DRAFT_505774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001514">
        <property type="protein sequence ID" value="KAF2437999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7K7"/>
    <dbReference type="OrthoDB" id="3352776at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF2437999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="173" mass="18978" checksum="F4E62145DF2DC0B1" modified="2023-09-13" version="1">MSSPSDNPRATTICATAARFCHLFVTGASPADILSQCFTSNPKITEHGPQWASMRLPFLSRTFTGRRAEATQDDQSCDQYFDVLGVTLSFHPQSDAIPPENEFIVSTGEGRKEAVVVRAKSRISSVKTGIEWEETFVFMFGEFDGEGRIGHLEIWSDGLSAWAAVGGERNAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7W5</accession>
    <name>A0A9P4P7W5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">P171DRAFT_436834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001512">
        <property type="protein sequence ID" value="KAF2438333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7W5"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="57"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF2438333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="275" mass="30801" checksum="55A24AD00F451135" modified="2023-09-13" version="1">MPPGYNTQQKAAISQFMSFASTDQKTAVKHLKNAGWDSSAAVTAYFSGGGGSGIVSSTKSNLNKFFDSYRDDVKNSPDSVGPDGAMGYFEKLGVDLEGMDALAVMEVIQAPTMGEMSREGFVEGWSSLNADTLDKQKAHLKSLKQRLPSDKAAFEKVYKYTFLLGKPAGAKAVPLESALAFWELLFTSPLSALRWSTPNSPWFEWWTEFLNAEWKKSVNKDMWNETLKFAKLTLEDEAMSFWDESSSWPSVIDDFVEWVKKEKRPSQDNVDEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P7Z8</accession>
    <name>A0A9P4P7Z8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_525574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2438992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P7Z8"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="128" mass="13488" checksum="711F158EE4EFAF85" modified="2023-09-13" version="1">MFLTKNGELLEIDISAKFTHYPFTGVTGRLYPVVGTSVPGVKVRVNFGNDLVSTPFVWTPGNEADSGIAFVNGKEEALARKPLLRRRTTNVVNDLKTANGASEGEDASAGAEAPTAVDVQPASIKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P8Y2</accession>
    <name>A0A9P4P8Y2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_436393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001510">
        <property type="protein sequence ID" value="KAF2439033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P8Y2"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2439033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="284" mass="32554" checksum="773E1ADF38A8F5D0" modified="2023-09-13" version="1">MGHRRDPFPFPILCAAKIGKKEPRDGDELTLEITEDLLDTEYNVFYERGTFATHFKARAMVARPLTHLTLRLTHEDWWNWSVDPTRPFSFQGQLYLEPAIGSSPNSLGLPKGVDYMELLAAKRRAGEDVGEHGGWGAIVGRLPDLKELKLVLETFDAKADRLEKIVECAKTWRFPIEDSSFELVWDGEVEDASWGIEPGELDRNYNKPMIIQEEEDDDDEDRFTDDERDSEDAYDSSDDESSSEDDEATYAPPLPPPPSWNRLVTRFEARVVRFARRKREQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P929</accession>
    <name>A0A9P4P929_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">P171DRAFT_156587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001511">
        <property type="protein sequence ID" value="KAF2438794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P929"/>
    <dbReference type="OrthoDB" id="3920481at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF2438794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000799764"/>
        </source>
    </evidence>
    <sequence length="148" mass="15649" checksum="2A491661863BD46C" modified="2023-09-13" version="1">MSDDANTATYSTPSQALCYFSLPVTSTHFSIETPGTTPLHTYSPDIRPDPHHPLLASRHLSPEHHMASDHSSLLQLQTSAANRPAAQPLQEGASSPPGSASSSSSGSTSPSTLCCSRCRRESGGSMVQFGTNIYYCSHCARMTGYCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9P4P972</accession>
    <name>A0A9P4P972_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">P171DRAFT_435665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Karstenula rhodostoma CBS 690.94</name>
        <dbReference type="NCBI Taxonomy" id="1392251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Karstenula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2020" name="Stud. Mycol." volume="0" first="0" last="0">
            <title>101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens.</title>
            <authorList>
                <person name="Haridas S."/>
                <person name="Albert R."/>
                <person name="Binder M."/>
                <person name="Bloem J."/>
                <person name="Labutti K."/>
                <person name="Salamov A."/>
                <person name="Andreopoulos B."/>
                <person name="Baker S."/>
                <person name="Barry K."/>
                <person name="Bills G."/>
                <person name="Bluhm B."/>
                <person name="Cannon C."/>
                <person name="Castanera R."/>
                <person name="Culley D."/>
                <person name="Daum C."/>
                <person name="Ezra D."/>
                <person name="Gonzalez J."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Liang C."/>
                <person name="Lipzen A."/>
                <person name="Lutzoni F."/>
                <person name="Magnuson J."/>
                <person name="Mondo S."/>
                <person name="Nolan M."/>
                <person name="Ohm R."/>
                <person name="Pangilinan J."/>
                <person name="Park H.-J."/>
                <person name="Ramirez L."/>
                <person name="Alfaro M."/>
                <person name="Sun H."/>
                <person name="Tritt A."/>
                <person name="Yoshinaga Y."/>
                <person name="Zwiers L.-H."/>
                <person name="Turgeon B."/>
                <person name="Goodwin S."/>
                <person name="Spatafora J."/>
                <person name="Crous P."/>
                <person name="Grigoriev I."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 690.94</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU001508">
        <property type="protein sequence ID" value="KAF2439801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9P4P972"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000799764">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="473"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
   